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Medicinal Cannabis

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https://www.readbyqxmd.com/read/29773359/-psychoactive-substances-use-in-r%C3%A3-union-island-and-mayotte-french-departments-in-indian-ocean
#1
Amélie Daveluy, Françoise Haramburu
INTRODUCTION: The government plan for the fight against drugs and addictive behaviors 2013-2017 includes several actions concerning French overseas territories, in particular to strengthen information on drug addiction. The Interministerial mission for combating drugs and addictive behaviors (MILD&CA) has commissioned the Bordeaux addictovigilance center to strengthen exchanges on addictovigilance with Réunion Island and Mayotte and to make an inventory of problematic drug use in these two French departments of Indian Ocean...
February 27, 2018: Thérapie
https://www.readbyqxmd.com/read/29761015/the-influence-of-thc-cbd-oromucosal-spray-on-driving-ability-in-patients-with-multiple-sclerosis-related-spasticity
#2
Elisabeth G Celius, Carlos Vila
Background: Driving ability is a key function for the majority of patients with multiple sclerosis (MS) to help maintain daily interactions. Both physical and cognitive disability, as well as treatments, may affect the ability to drive. Spasticity is a common symptom associated with MS, and it may affect driving performance either directly or via the medications used to treat it. In this article, we review the evidence relating the antispasticity medicine, Δ9 -tetrahydrocannabinol:cannabidiol (THC:CBD) oromucosal spray (Sativex® ), and its potential impact on driving performance...
May 2018: Brain and Behavior
https://www.readbyqxmd.com/read/29718956/a-reliable-and-validated-lc-ms-ms-method-for-the-simultaneous-quantification-of-4-cannabinoids-in-40-consumer-products
#3
Qingfang Meng, Beth Buchanan, Jonathan Zuccolo, Mathieu-Marc Poulin, Joseph Gabriele, David Charles Baranowski
In the past 50 years, Cannabis sativa (C. sativa) has gone from a substance essentially prohibited worldwide to one that is gaining acceptance both culturally and legally in many countries for medicinal and recreational use. As additional jurisdictions legalize Cannabis products and the variety and complexity of these products surpass the classical dried plant material, appropriate methods for measuring the biologically active constituents is paramount to ensure safety and regulatory compliance. While there are numerous active compounds in C...
2018: PloS One
https://www.readbyqxmd.com/read/29713172/gender-specific-association-of-functional-prodynorphin-68-bp-repeats-with-cannabis-exposure-in-an-african-american-cohort
#4
Vadim Yuferov, Eduardo R Butelman, Mary Jeanne Kreek
Background: Cannabis use disorders (CUDs) cause substantial neuropsychiatric morbidity and comorbidity. There is evidence for gender-based differences in CUDs, for instance, a greater prevalence in males than in females. The main active component of cannabis is delta 9-tetrahydrocannabinol (delta 9-THC), a partial agonist of the cannabinoid type 1 receptor. Preclinical studies show that genetic or pharmacological manipulation of the kappa opioid receptor/dynorphin system modulates the effects of delta 9-THC...
2018: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/29660159/cannabis-and-anti-cancer-drugs-societal-usage-and-expected-pharmacological-interactions-a-review
#5
REVIEW
Régis Bouquié, Guillaume Deslandes, Hélène Mazaré, Marion Cogné, Julien Mahé, Matthieu Grégoire, Pascale Jolliet
Cannabis is a plant that has been used for centuries to relieve a wide range of symptoms. Since the 1960s, interest in medical research into this plant has grown steadily. Already very popular for recreational use, a growing number of consumers not accustomed to using cannabis for psychoactive purposes, have begun to use it as an alternative or complement to mainstream pharmaceutical medicines. The principal unsubstantiated or "social" uses of cannabis are based mainly on data that is at best controversial, but usually not scientifically proven...
April 16, 2018: Fundamental & Clinical Pharmacology
https://www.readbyqxmd.com/read/29655919/endocannabinoid-system-in-systemic-lupus-erythematosus-first-evidence-for-a-deranged-2-arachidonoylglycerol-metabolism
#6
Luca Navarini, Tiziana Bisogno, Pamela Mozetic, Fabiana Piscitelli, Domenico Paolo Emanuele Margiotta, Fabio Basta, Antonella Afeltra, Mauro Maccarrone
The endocannabinoid (eCB) system plays a key role in many physiological and pathological conditions and its dysregulation has been described in several rheumatological and autoimmune diseases. Yet, its possible alteration in systemic lupus erythematosus (SLE) has never been investigated. Here, we aimed filling this gap in plasma and peripheral blood mononuclear cells (PBMCs) of patients with SLE and age- and sex- matched healthy subjects (HS). Liquid chromatography-mass spectrometry quantitation of eCB levels highlighted that plasma levels of 2-arachidonoylglycerol (2-AG) were significantly increased in SLE patients compared to HS (p = 0...
April 12, 2018: International Journal of Biochemistry & Cell Biology
https://www.readbyqxmd.com/read/29653439/medical-cannabis-an-oxymoron-physicians-perceptions-of-medical-cannabis
#7
Yuval Zolotov, Simon Vulfsons, Dana Zarhin, Sharon Sznitman
BACKGROUND: Medical cannabis policies are changing in many places around the world, and physicians play a major role in the implementation of these policies. The aim of this study was to gain a deeper understanding of physicians' views on medical cannabis and its possible integration into their clinic, as well as to identify potential underlying factors that influence these perceptions. METHODS: Qualitative narrative analysis of in-depth interviews with twenty-four Israeli physicians from three specialties (pain medicine, oncology and family medicine)...
April 10, 2018: International Journal on Drug Policy
https://www.readbyqxmd.com/read/29651709/-cannabinoid-therapy-in-practice
#8
REVIEW
T Rasche, D Emmert, C Stieber, M Mücke, R Conrad
BACKGROUND: In recent years, the media and scientists have shown increased interest in cannabis-based drugs. OBJECTIVES: Background information about cannabis-based drugs and their mechanism of action as well as discussion of possible applications as supportive therapy or in palliative medicine, respectively, are presented. MATERIALS AND METHODS: The recent literature was examined and evaluated. RESULTS: In many medical fields, we do not have sufficient evidence for the efficacy of cannabinoids...
April 12, 2018: Der Urologe. Ausg. A
https://www.readbyqxmd.com/read/29648861/an-assessment-of-concurrent-cannabidiol-and-%C3%AE-%C3%A2-tetrahydrocannabinol-administration-in-place-aversion-and-taste-avoidance-conditioning
#9
Briana J Hempel, Matthew M Clasen, Katharine H Nelson, Claudia J Woloshchuk, Anthony L Riley
Rising interest in medical marijuana has prompted research into its phytocannabinoid constituents, particularly Δ⁹-tetrahydrocannabinol (THC) and cannabidiol (CBD). Coadministration of CBD with THC has been shown to modulate a number of THC's effects, including its negative stimulus properties (e.g., anxiety, paranoia, psychosis) in a clinical setting. The present series of experiments extended these analyses by examining the ability of CBD to impact the aversive effects of THC as assessed in a combined taste and place conditioning procedure...
April 2018: Experimental and Clinical Psychopharmacology
https://www.readbyqxmd.com/read/29642759/cannabis-use-and-knowledge-among-medical-students-at-the-university-of-the-free-state-bloemfontein-south-africa
#10
Roshini Jain, Ch Chiech Chang, Mpho A Koto, Alden N Geldenhuys, Richard J Nichol, Gina Joubert
OBJECTIVE: The study aimed to investigate the prevalence of cannabis use among undergraduate medical students of the University of the Free State (UFS), and the extent of their knowledge about the substance. METHOD: This cross-sectional study included five year groups of undergraduate medical students. A self-administered, anonymous questionnaire was used. RESULTS: Of the 643 medical students, 541 (84.1%) completed the questionnaire. In total, 161 (30...
April 11, 2018: Journal of Child and Adolescent Mental Health
https://www.readbyqxmd.com/read/29625706/pharmaceutical-cognitive-doping-in-students-a-chimeric-way-to-get-a-head
#11
Louise Carton, Nicolas Cabé, Olivier Ménard, Sylvie Deheul, Anne-Sylvie Caous, David Devos, Olivier Cottencin, Régis Bordet
For students, the pressing demands for memorization, top-level performance, and peer competition create an environment favorable for pharmaceutical cognitive doping behavior. We aimed to describe recent practices and the benefit/risk ratio of such behavior and to discuss the issues at stake. The prevalence of pharmaceutical cognitive doping among students has been reported from 1.3% to 33% across studies, with variations depending on country and definition of pharmaceutical cognitive doping. The therapeutic classes most frequently cited as being diverted for doping purposes are psychostimulants and nootropics (methylphenidate, modafinil, piracetam), corticosteroids, sedative drugs and beta-blockers...
March 6, 2018: Thérapie
https://www.readbyqxmd.com/read/29609727/medical-cannabis-and-the-treatment-of-obstructive-sleep-apnea-an-american-academy-of-sleep-medicine-position-statement
#12
Kannan Ramar, Ilene M Rosen, Douglas B Kirsch, Ronald D Chervin, Kelly A Carden, R Nisha Aurora, David A Kristo, Raman K Malhotra, Jennifer L Martin, Eric J Olson, Carol L Rosen, James A Rowley
The diagnosis and effective treatment of obstructive sleep apnea (OSA) in adults is an urgent health priority. Positive airway pressure (PAP) therapy remains the most effective treatment for OSA, although other treatment options continue to be explored. Limited evidence citing small pilot or proof of concept studies suggest that the synthetic medical cannabis extract dronabinol may improve respiratory stability and provide benefit to treat OSA. However, side effects such as somnolence related to treatment were reported in most patients, and the long-term effects on other sleep quality measures, tolerability, and safety are still unknown...
April 15, 2018: Journal of Clinical Sleep Medicine: JCSM: Official Publication of the American Academy of Sleep Medicine
https://www.readbyqxmd.com/read/29602151/usefulness-of-hair-analysis-and-psychological-tests-for-identification-of-alcohol-and-drugs-of-abuse-consumption-in-driving-license-regranting
#13
Elena Lendoiro, Ana de Castro, Cristian Jiménez-Morigosa, Xosé A Gomez-Fraguela, Manuel López-Rivadulla, Angelines Cruz
The implementation of the points-based driving license helps to change the drivers' behavior and is related to a reduction of traffic accidents and fatalities. In Spain, when a driver loses all points, the driving license is revoked, so the driver must enroll on a Driver Awareness and Re-education (DARE) course. However, at the moment offenders are not submitted to any test to confirm absence of alcohol or drugs of abuse consumption, even when 9% of Spanish drivers lose their driving license for driving under the influence (DUI)...
March 20, 2018: Forensic Science International
https://www.readbyqxmd.com/read/29588916/medicinal-cannabis-on-prescription-in-the-netherlands-statistics-for-2003-2016
#14
Bas de Hoop, Eibert R Heerdink, Arno Hazekamp
No abstract text is available yet for this article.
2018: Cannabis and Cannabinoid Research
https://www.readbyqxmd.com/read/29560069/cannabinoid-hyperemesis-syndrome-public-health-implications-and-a-novel-model-treatment-guideline
#15
Jeff Lapoint, Seth Meyer, Charles K Yu, Kristi L Koenig, Roneet Lev, Sayone Thihalolipavan, Katherine Staats, Christopher A Kahn
Introduction: Cannabinoid hyperemesis syndrome (CHS) is an entity associated with cannabinoid overuse. CHS typically presents with cyclical vomiting, diffuse abdominal pain, and relief with hot showers. Patients often present to the emergency department (ED) repeatedly and undergo extensive evaluations including laboratory examination, advanced imaging, and in some cases unnecessary procedures. They are exposed to an array of pharmacologic interventions including opioids that not only lack evidence, but may also be harmful...
March 2018: Western Journal of Emergency Medicine
https://www.readbyqxmd.com/read/29541774/the-role-of-aging-drug-dependence-and-hepatitis-c-comorbidity-in-alcoholism-cortical-compromise
#16
Edith V Sullivan, Natalie M Zahr, Stephanie A Sassoon, Wesley K Thompson, Dongjin Kwon, Kilian M Pohl, Adolf Pfefferbaum
Importance: The prevalence of alcohol misuse increased substantially over a decade in adults, particularly in those aged 65 years or older. Ramifications for brain structural integrity are significant, especially in older adults. Objectives: To combine cross-sectional, longitudinal data to test age-alcoholism interactions and examine the association between prevalent comorbidities (drug dependence and hepatitis C virus [HCV] infection) and cortical volume deficits in alcohol dependence...
March 14, 2018: JAMA Psychiatry
https://www.readbyqxmd.com/read/29533978/cannabinoid-receptors-and-the-endocannabinoid-system-signaling-and-function-in-the-central-nervous-system
#17
REVIEW
Shenglong Zou, Ujendra Kumar
The biological effects of cannabinoids, the major constituents of the ancient medicinal plant Cannabis sativa (marijuana) are mediated by two members of the G-protein coupled receptor family, cannabinoid receptors 1 (CB1R) and 2. The CB1R is the prominent subtype in the central nervous system (CNS) and has drawn great attention as a potential therapeutic avenue in several pathological conditions, including neuropsychological disorders and neurodegenerative diseases. Furthermore, cannabinoids also modulate signal transduction pathways and exert profound effects at peripheral sites...
March 13, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29525583/a-comparative-analysis-of-suicides-in-greece-s-main-port-city-area-of-piraeus-before-2006-2010-and-during-2011-2015-the-country-s-severe-economic-crisis
#18
Antonios Paraschakis, Ioannis Michopoulos, Vasiliki Efstathiou, Christos Christodoulou, Ilias Boyokas, Athanassios Douzenis
We investigated all cases of completed suicide in the city area of Piraeus -the largest port in Greece- for the years 2006 up to 2015. We searched, among others, parameters regarding the victims' psychiatric medication intake and drug and alcohol use that -to the best of our knowledge- had never been investigated before by a study on suicides in Greece within the crisis' years. We documented variations before (2006-2010) and during (2011-2015) crisis. Information was provided by the victims' forensic records at the Piraeus Department of Forensic Medicine...
May 2018: Journal of Forensic and Legal Medicine
https://www.readbyqxmd.com/read/29513392/cannabis-based-medicines-for-chronic-neuropathic-pain-in-adults
#19
REVIEW
Martin Mücke, Tudor Phillips, Lukas Radbruch, Frank Petzke, Winfried Häuser
BACKGROUND: This review is one of a series on drugs used to treat chronic neuropathic pain. Estimates of the population prevalence of chronic pain with neuropathic components range between 6% and 10%. Current pharmacological treatment options for neuropathic pain afford substantial benefit for only a few people, often with adverse effects that outweigh the benefits. There is a need to explore other treatment options, with different mechanisms of action for treatment of conditions with chronic neuropathic pain...
March 7, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29506645/-cannabinoids-for-neuropathic-pain-management
#20
Lasse Østergaard Andersen, Thomas Peter Enggaard, Jette Højsted
Pharmacological treatment of neuropathic pain is associated with side effects and limited efficacy. Recently, the interest in cannabis-based medicine has led to legalisation of medical cannabis in some countries. The aim of this review is to evaluate the evidence of cannabinoids in neuropathic pain. Seventeen trials were identified; eight reported an analgesic efficacy of cannabis-based medicine, and the remaining trials showed no analgesic efficacy. Conclusions were limited by design of studies and short duration of treatment...
February 26, 2018: Ugeskrift for Laeger
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