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https://www.readbyqxmd.com/read/29924455/igg4-related-disease-review-of-the-histopathologic-features-differential-diagnosis-and-therapeutic-approach
#1
REVIEW
Jacob R Bledsoe, Emanuel Della-Torre, Lucrezia Rovati, Vikram Deshpande
Immunoglobulin G4-related disease (IgG4-RD) is an uncommon disorder that demonstrates characteristic clinicopathologic features including sclerosing lesions with storiform fibrosis, increased IgG4+ plasma cells with an increased IgG4+/IgG+ plasma cell ratio, obliterative phlebitis, and often an increased serum IgG4 level. This review summarizes the characteristic histopathologic and clinical features of IgG4-RD with detailed discussion of the histopathologic characteristics of the most commonly involved anatomic sites...
June 2018: APMIS: Acta Pathologica, Microbiologica, et Immunologica Scandinavica
https://www.readbyqxmd.com/read/29923642/fulminant-subacute-sclerosing-panencephalitis-not-only-a-disease-of-the-past
#2
Denise L Chan, Helen Young, Pamela Palasanthiran, William Rawlinson, Paul Gray, P Ian Andrews
No abstract text is available yet for this article.
June 20, 2018: Journal of Paediatrics and Child Health
https://www.readbyqxmd.com/read/29922759/serum-mirna-122-is-an-independent-biomarker-of-survival-in-patients-with-primary-sclerosing-cholangitis
#3
Kilian Friedrich, Carina Baumann, Andreas Wannhoff, Christian Rupp, Arianeb Mehrabi, Karl Heinz Weiss, Daniel N Gotthardt
BACKGROUND AND AIMS: The disease course of primary sclerosing cholangitis (PSC) is variable and difficult to predict. MicroRNA-122 (miR-122) is associated with various liver diseases. We investigated the value of miR-122 as a biomarker for the disease course of PSC. METHODS: We determined serum miR-122 levels in a long-term, prospective cohort of 114 PSC patients and a second validation cohort. RESULTS: Based on miR-122 levels, PSC patients were assigned to low or high level miR-122 groups...
June 2018: Journal of Gastrointestinal and Liver Diseases: JGLD
https://www.readbyqxmd.com/read/29916092/multiple-hepatic-sclerosing-hemangiomas-a-case-report-and-review-of-the-literature
#4
Kyohei Yugawa, Tomoharu Yoshizumi, Noboru Harada, Takashi Motomura, Norifumi Harimoto, Shinji Itoh, Toru Ikegami, Yuji Soejima, Yoshihiko Maehara
BACKGROUND: Hepatic sclerosing hemangioma, a very rare benign tumor, is characterized by fibrosis and hyalinization occurring in association with degeneration of a hepatic cavernous hemangioma. Such atypical hemangiomas can be diagnosed incorrectly as primary or metastatic malignancies based on imaging characteristics. We present herein a rare case of giant and multiple hepatic sclerosing hemangiomas that are difficult to differentiate from hepatic malignancies and review the relevant literature...
June 19, 2018: Surgical Case Reports
https://www.readbyqxmd.com/read/29913531/volumetric-laser-endomicroscopy-in-the-biliary-and-pancreatic-ducts-a-feasibility-study-with-histological-correlation
#5
Juan E Corral, Omar Y Mousa, Murli Krishna, Iris J M Levink, Khela R Pursell, Mohammad Afsh, Paul T Kröner, Denise M Harnois, Herbert C Wolfsen, Michael B Wallace, Frank J Lukens
BACKGROUND:  Volumetric laser endomicroscopy (VLE) provides circumferential images 3 mm into the biliary and pancreatic ducts. We aimed to correlate VLE images with the normal and abnormal microstructure of these ducts. METHODS: Samples from patients undergoing hepatic or pancreatic resection were evaluated. VLE images were collected using a low-profile VLE catheter inserted manually into the biliary and pancreatic ducts ex vivo. Histological correlation was assessed by two unblinded investigators...
June 18, 2018: Endoscopy
https://www.readbyqxmd.com/read/29912047/long-term-outcomes-and-risk-factors-after-adult-living-donor-liver-transplantation
#6
Daisuke Imai, Tomoharu Yoshizumi, Kazuhito Sakata, Toru Ikegami, Shinji Itoh, Noboru Harada, Takashi Motomura, Takeo Toshima, Yohei Mano, Yuji Soejima, Yoshihiko Maehara
BACKGROUND: Although risk factors for the long-term mortality of liver transplantation are well described, there is a lack of detailed study regarding these factors for adult living donor liver transplantation (LDLT). METHODS: We retrospectively analyzed 528 adult LDLT recipients in our hospital. The risk factors were analyzed for overall deaths >5 years post-LDLT. RESULTS: Over the 20-year follow-up, 137 patients died. Patient survival at 1, 3, 5, and 10 years post-LDLT was 87...
June 13, 2018: Transplantation
https://www.readbyqxmd.com/read/29909599/survival-of-aggressive-variants-of-papillary-thyroid-carcinoma-in-patients-under-55-years-old-a-seer-population-based-retrospective-analysis
#7
Jianhua Feng, Fei Shen, Wensong Cai, Xiaoxiong Gan, Xingyan Deng, Bo Xu
BACKGROUND: Patients younger than 55 years of age with papillary thyroid carcinoma (PTC) have excellent survival. Diffuse sclerosing variant (DSV) and tall cell variant (TCV) of PTC are associated with aggressiveness; the survival of patients <55 years of age with these variants is still unclear. We aim to investigate the clinicopathological features and survival of these variants in the age group <55 years. METHODS: All adult patients (<55 years old) with DSV, TCV and conventional PTC (CPTC) came from the Surveillance, Epidemiology, and End Results program (1988-2013)...
June 16, 2018: Endocrine
https://www.readbyqxmd.com/read/29901555/spectrum-of-pediatric-autoimmune-liver-disease-and-validation-of-its-diagnostic-scores-in-indian-children
#8
Vikrant Sood, Bikrant Bihari Lal, Dinesh Rawat, Rajeev Khanna, Archana Rastogi, Chhagan Bihari, Guresh Kumar, Seema Alam
OBJECTIVES: There is limitedliterature on the spectrum of pediatric autoimmune liver disease (AILD, encompassing both autoimmune hepatitis/AIH and autoimmune sclerosing cholangitis/ASC) in Asian populations and its diagnostic scores similarly require further validation. This work thus aimed to study the clinical characteristics, and to validate available diagnostic criteria in the local pediatric AILD cohort. METHODS: A review of all pediatric AILD cases, presenting over a 6 year (2011-2017) period was done, along with comparison of the available diagnostic scores: original (1999), simplified (2008) score and new proposed (2017) score...
June 12, 2018: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/29901259/the-role-of-mri-and-ercp-in-the-evaluation-of-disease-activity-and-severity-in-primary-sclerosing-cholangitis
#9
Andrea Tenca, Harri Mustonen, Kati Lind, Eila Lantto, Kaija-Leena Kolho, Sonja Boyd, Johanna Arola, Kalle Jokelainen, Martti Färkkilä
BACKGROUND AND AIMS: Endoscopic retrograde cholangiography (ERCP) has been considered the gold standard for the diagnosis and follow-up of primary sclerosing cholangitis, but it has been replaced by less invasive magnetic resonance imaging and cholangio-pancreatography (MRI-MRCP). However, the role of these two techniques in the evaluation of disease activity and severity needs to be elucidated. METHODS: Patients with primary sclerosing cholangitis (n: 48, male 31, median age: 35...
June 14, 2018: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/29896575/sclerosing-encapsulating-peritonitis-after-living-donor-liver-transplantation-a-case-series-kyoto-experience
#10
Vusal Aliyev, Shintaro Yagi, Ahmed Hammad, Amr Badawy, Yudai Sasaki, Yuki Masano, Gen Yamamoto, Naoko Kamo, Kojiro Taura, Hideaki Okajima, Toshimi Kaido, Shinji Uemoto
Sclerosing encapsulating peritonitis (SEP), or abdominal cocoon is a rare cause of intestinal obstruction, and still etiology remains unknown. We report a series of 4 patients with abdominal cocoon, and all the 4 patients had previously undergone living-donor liver transplantation (LDLT). There was no evidence of SEP before and during LDLT. At the time of diagnosis of SEP, 3 out of 4 patients had ascites. First and fourth patients had multiple episodes or attacks of cholangitis, which were managed by percutaneous transhepatic biliary drainage and hepaticojejunostomy, respectively...
May 2018: Annals of Hepato-Biliary-Pancreatic Surgery
https://www.readbyqxmd.com/read/29894005/possible-roles-of-basophils-in-chronic-itch
#11
REVIEW
Takashi Hashimoto, Jordan D Rosen, Kristen M Sanders, Gil Yosipovitch
Basophils are blood granulocytes and normally constitute less than 1% of blood peripheral leukocytes. Basophils share some morphological and functional similarities with mast cells, and basophils were once regarded as redundant and negligible circulating mast cells. However, recent studies reveal the indispensable roles of basophils in various diseases, including allergic and pruritic diseases. Basophils may be involved in itch through the mediation of a Th2 immune response, interaction with other cells in the skin, and secretion of a wide variety of itch-related mediators, e...
June 12, 2018: Experimental Dermatology
https://www.readbyqxmd.com/read/29889797/whorling-sclerosing-variant-meningioma-of-the-spine-surgical-management-and-outcome-of-an-extremely-rare-case
#12
Keyvan Eghbal, Amirreza Dehghanian, Fariborz Ghaffarpasand
STUYD DESIGN: Case Report OBJECTIVE.: To report surgical resection of multiple ventral cervical and thoracic lesion being diagnosed as whorling-sclerosing variant meningioma (WSM) and subsequent stabilization of cervicothoracic spine. SUMMARY OF BACKGROUND DATA: WSM is a rare histopathology variant of meningioma which is mostly reported in brain and only one case of cervical spine WSM has been reported. Because of the rarity of WSM, there is a paucity of information regarding the clinical, radiological and histopathologic characteristics...
June 8, 2018: Spine
https://www.readbyqxmd.com/read/29886518/update-in-the-care-and-management-of-patients-with-primary-sclerosing-cholangitis
#13
REVIEW
Mai Sedki, Cynthia Levy
PURPOSE OF REVIEW: Primary sclerosing cholangitis (PSC) is a progressive cholestatic liver disease for which specific medical therapy is not available. The goals of treatment are primarily early detection and management of complications. In this review, we discuss novel therapies under evaluation and provide the foundation for surveillance strategies. RECENT FINDINGS: Drugs under investigation include norursodeoxycholic acid, nuclear receptor agonists, anti-fibrotics, antibiotics, and anti-inflammatory drugs...
June 9, 2018: Current Gastroenterology Reports
https://www.readbyqxmd.com/read/29885186/lenz-majewskihyperostotic-dwarfism-a-pakistani-patient-with-atypical-features
#14
Ghulam Murtaza, Adeel Khalid, Muhammad Armughan Ali, Arsalan Majeed Adam, Warisha Ikhlaq, Ayaz Ahmed
Lenz-Majewski Hyperostotic Dwarfism (LMHD) is an extremely rare congenital, sclerosing bone dysplasia that causes cranio-tubular hyperostosis, ectodermal dysplasia (cutis laxa and enamel hypoplasia), osseous dysgenesis of hands and feet with diaphyseal cortical thickening of tubular bones and intellectual disability. Only a few cases of this syndrome have been reported in the literature so far. We report another case of LMHD with cranio-tubular hyperostosis, cutis laxa, wide open anterior and posterior fontannels, hypertelorism and thickening of diaphysis of tubular bones in a six months old Pakistani female patient...
May 2018: JPMA. the Journal of the Pakistan Medical Association
https://www.readbyqxmd.com/read/29883229/endoscopic-management-of-primary-sclerosing-cholangitis
#15
James H Tabibian, Todd H Baron
Primary sclerosing cholangitis (PSC) is a rare but clinically important cholestatic liver disease. Histopathologically and cholangiographically, PSC is characterized by intra- and/or extra-hepatic bile duct inflammation and fibro-obliteration, which ultimately leads to biliary cirrhosis and related sequelae, including development of hepatobiliary and colorectal carcinomata. PSC can be diagnosed at essentially any age and carries a median survival of 15-20 years, regardless of age at diagnosis, and is a foremost risk factor for cholangiocarcinoma...
June 8, 2018: Expert Review of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/29882287/ultrasound-guided-microfoam-sclerotherapy-with-polidocanol-for-symptomatic-giant-hepatic-cyst-initial-experience
#16
Yuji Eso, Akihiro Furuta, Atsushi Takai, Ken Takahashi, Yoshihide Ueda, Hiroyuki Marusawa, Hiroshi Seno
AIM: In cases of symptomatic giant hepatic cysts, appropriate treatment is required to relieve symptoms. Ethanol, minocycline hydrochloride, and ethanolamine oleate have been conventionally used for ultrasound (US)-guided sclerotherapy. However, liquid sclerosing agents could mix with the residual fluid in the cyst and reduce their sclerotic effects. We performed US-guided microfoam sclerotherapy using polidocanol for three patients and evaluated its efficacy and safety. METHODS: Between May 2016 and March 2017, three female patients with symptomatic giant hepatic cysts were referred to our hospital...
June 7, 2018: Hepatology Research: the Official Journal of the Japan Society of Hepatology
https://www.readbyqxmd.com/read/29882252/the-impact-of-ileal-pouch-anal-anastomosis-on-graft-survival-following-liver-transplantation-for-primary-sclerosing-cholangitis
#17
P J Trivedi, J Reece, R W Laing, E Slaney, R Cooney, B K Gunson, S K Kamarajah, T Pinkney, F Thompson, P Muiesan, A Schlegel, G M Hirschfield, T Iqbal, J Ferguson
BACKGROUND: Liver transplantation is the only life-extending intervention for primary sclerosing cholangitis (PSC). Given the co-existence with colitis, patients may also require colectomy; a factor potentially conferring improved post-transplant outcomes. AIM: To determine the impact of restorative surgery via ileal pouch-anal anastomosis (IPAA) vs retaining an end ileostomy on liver-related outcomes post-transplantation. METHODS: Graft survival was evaluated across a prospectively accrued transplant database, stratified according to colectomy status and type...
June 8, 2018: Alimentary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/29881604/association-between-smoking-and-risk-of-primary-sclerosing-cholangitis-a-systematic-review-and-meta-analysis
#18
Karn Wijarnpreecha, Panadeekarn Panjawatanan, Omar Y Mousa, Wisit Cheungpasitporn, Surakit Pungpapong, Patompong Ungprasert
Background/Objectives: Studies have suggested that smokers may have a lower risk of primary sclerosing cholangitis (PSC) although the results have been inconsistent. This systematic review and meta-analysis was conducted to summarize all available data to better characterize this association. Methods: A comprehensive literature review was conducted using Medline and Embase databases through January 2018 to identify all studies that compared the risk of PSC among current/former smokers versus nonsmokers...
May 2018: United European Gastroenterology Journal
https://www.readbyqxmd.com/read/29875595/sclerosing-mesenteritis
#19
Chien-Chin Chen, Kai-Sheng Liao, Chih-Jen Huang
No abstract text is available yet for this article.
April 2018: Ci Ji Yi Xue za Zhi, Tzu-chi Medical Journal
https://www.readbyqxmd.com/read/29873924/differential-diagnostic-significance-of-epithelial-and-stromal-cd10-expression-in-tumors-of-trichogenic-origin
#20
Hermann Kneitz, Stefanie Fetzer, Matthias Goebeler, Eva-Bettina Bröcker
BACKGROUND AND OBJECTIVES: The histological differential diagnosis between benign trichogenic skin tumors and basal cell carcinoma may be challenging. We therefore set out to investigate whether expression of CD10, a cell surface protein with neutral endopeptidase activity, might be a suitable marker for the histological differential diagnosis of trichogenic skin tumors. PATIENTS AND METHODS: We immunohistochemically analyzed 119 cases of benign trichogenic skin tumors and basal cell carcinoma...
June 2018: Journal der Deutschen Dermatologischen Gesellschaft, Journal of the German Society of Dermatology: JDDG
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