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Acid-sensing ion channels

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https://www.readbyqxmd.com/read/28103434/analgesic-effect-of-quetiapine-in-a-mouse-model-of-cancer-induced-bone-pain
#1
Mi Hwa Heo, Jin Young Kim, Ilseon Hwang, Eunyoung Ha, Keon Uk Park
Background/Aims: Cancer-induced bone pain (CIBP) is one of the most common pains in patients with advanced neoplasms. Because of treatment-associated side effects, more than half of cancer patients are reported to have inadequate and undermanaged pain control. New mechanism-based therapies must be developed to reduce cancer pain. Quetiapine is a commonly used atypical antipsychotic drug. We report a study of the potential analgesic effects of quetiapine in a mouse model of CIBP and examine the mechanism of bone pain by analyzing the expression of various nociceptors...
January 20, 2017: Korean Journal of Internal Medicine
https://www.readbyqxmd.com/read/28103019/highly-water-stable-novel-lanthanide-wheel-cluster-organic-frameworks-featuring-coexistence-of-hydrophilic-cage-like-chambers-and-hydrophobic-nanosized-channels
#2
Yuan-Yuan Zhou, Yang Shi, Bing Geng, Qi-Bing Bo
In attempts to investigate the potential luminescent sensing materials for sensitive detection of environmental pollutants, a new family of lanthanide wheel cluster organic frameworks (Ln-WCOFs) UJN-Ln4 has been constructed by employing one of the cycloalkane dicarboxylic acid derivatives. Adopting different conformations, the ligand links Ln4 second building units (SBUs) and Ln24 tertiary building unit (TBUs) to form a unique wheel cluster layer-pillared 3D framework featuring the coexistence of hydrophobic nanosized channels and trigonal anti-prism arrays with hydrophilic cage-like chambers...
January 19, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28072525/anionic-lanthanide-mofs-as-a-platform-for-iron-selective-sensing-systematic-color-tuning-and-efficient-nanoparticle-catalysis
#3
Ya-Pan Wu, Guo-Wang Xu, Wen-Wen Dong, Jun Zhao, Dong-Sheng Li, Jian Zhang, Xianhui Bu
New porous anionic Ln-MOFs, namely, [Me2NH2][Ln(CPA)2(H2O)2] (Ln = Eu, Gd), have been prepared through the self-assembly of 5-(4-carboxy phenyl)picolinic acid (H2CPA) and lanthanide ions. They feature open anionic frameworks with 1-D hydrophilic channels and exchangeable dimethylamine ions. The Eu phase could detect Fe(3+) ions with high selectivity and sensitivity in either aqueous solution or biological condition. The ratios of lanthanide ions on this structure platform could be rationally tuned to not only achieve dichromatic emission colors with linear correlation but also attain three primary colors (RGB) and even white light with favorable correlated color temperature...
January 10, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/28062311/trpa1-and-trpv1-antagonists-do-not-inhibit-human-acidosis-induced-pain
#4
Matthias G Schwarz, Barbara Namer, Peter W Reeh, Michael J M Fischer
: Acidosis occurs in a variety of pathophysiological and painful conditions where it is thought to excite or contribute to excitation of nociceptive neurons. Despite potential clinical relevance the principal receptor for sensing acidosis is unclear, but several receptors have been proposed. We investigated the contribution of the acid sensing ion channels, TRPV1 and TRPA1 to peripheral pain signaling. We first established a human pain model using intra-epidermal injection of TRPA1 agonist carvacrol...
January 3, 2017: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/28030818/asic1-promotes-differentiation-of-neuroblastoma-by-negatively-regulating-notch-signaling-pathway
#5
Mingli Liu, Koichi Inoue, Tiandong Leng, An Zhou, Shanchun Guo, Zhi-Gang Xiong
In neurons, up-regulation of Notch activity either inhibits neurite extension or causes retraction of neurites. Conversely, inhibition of Notch1 facilitates neurite extension. Acid-sensing ion channels (ASICs) are a family of proton-gated cation channels, which play critical roles in synaptic plasticity, learning and memory and spine morphogenesis. Our pilot proteomics data from ASIC1a knock out mice implicated that ASIC1a may play a role in regulating Notch signaling, therefore, we explored whether or not ASIC1a regulates neurite growth during neuronal development through Notch signaling...
24, 2016: Oncotarget
https://www.readbyqxmd.com/read/28028533/extracellular-electrical-recording-of-ph-triggered-bursts-in-c6-glioma-cell-populations
#6
Paulo R F Rocha, Maria C R Medeiros, Ulrike Kintzel, Johannes Vogt, Inês M Araújo, Ana L G Mestre, Volker Mailänder, Paul Schlett, Melanie Dröge, Leonid Schneider, Fabio Biscarini, Dago M de Leeuw, Henrique L Gomes
Glioma patients often suffer from epileptic seizures because of the tumor's impact on the brain physiology. Using the rat glioma cell line C6 as a model system, we performed long-term live recordings of the electrical activity of glioma populations in an ultrasensitive detection method. The transducer exploits large-area electrodes that maximize double-layer capacitance, thus increasing the sensitivity. This strategy allowed us to record glioma electrical activity. We show that although glioma cells are nonelectrogenic, they display a remarkable electrical burst activity in time...
December 2016: Science Advances
https://www.readbyqxmd.com/read/28003157/asic-channel-inhibition-enhances-excitotoxic-neuronal-death-in-an-in-vitro-model-of-spinal-cord-injury
#7
Graciela L Mazzone, Priyadharishini Veeraraghavan, Carlota Gonzalez-Inchauspe, Andrea Nistri, Osvaldo D Uchitel
In the spinal cord high extracellular glutamate evokes excitotoxic damage with neuronal loss and severe locomotor impairment. During the cell dysfunction process, extracellular pH becomes acid and may activate acid-sensing ion channels (ASICs) which could be important contributors to neurodegenerative pathologies. Our previous studies have shown that transient application of the glutamate analog kainate (KA) evokes delayed excitotoxic death of spinal neurons, while white matter is mainly spared. The present goal was to enquire if ASIC channels modulated KA damage in relation to locomotor network function and cell death...
December 19, 2016: Neuroscience
https://www.readbyqxmd.com/read/27989169/multifunctional-luminescent-eu-iii-based-metal-organic-framework-for-sensing-methanol-and-detection-and-adsorption-of-fe-iii-ions-in-aqueous-solution
#8
Jian Wang, Min Jiang, Ling Yan, Ren Peng, Mengjie Huangfu, Xinxin Guo, Yang Li, Pengyan Wu
A novel lanthanide-organic framework (Eu-HODA), consisting of 2,2',3,3'-oxidiphthalic acids as efficient sensitizing units, is assembled and characterized. Eu-HODA features rare chiral helical channels despite the achiral nature of H4ODA. It is found that this MOF shows a unique luminescent response to methanol, in contrast to n-propanol and ethanol. Eu-HODA reveals a turn-off luminescence switching initiated by acetone molecules with an EC50 of 0.03 vol %, which is below the occupational exposure limit of acetone stipulated by the American Conference of Governmental Industrial Hygienists...
December 19, 2016: Inorganic Chemistry
https://www.readbyqxmd.com/read/27983655/fabrication-of-a-horizontal-and-a-vertical-large-surface-area-nanogap-electrochemical-sensor
#9
Jules L Hammond, Mark C Rosamond, Siva Sivaraya, Frank Marken, Pedro Estrela
Nanogap sensors have a wide range of applications as they can provide accurate direct detection of biomolecules through impedimetric or amperometric signals. Signal response from nanogap sensors is dependent on both the electrode spacing and surface area. However, creating large surface area nanogap sensors presents several challenges during fabrication. We show two different approaches to achieve both horizontal and vertical coplanar nanogap geometries. In the first method we use electron-beam lithography (EBL) to pattern an 11 mm long serpentine nanogap (215 nm) between two electrodes...
December 14, 2016: Sensors
https://www.readbyqxmd.com/read/27976056/pain-sensations-in-gastro-esophageal-reflux-disease-may-be-mediated-by-acid-sensing-ion-channels-evidence-for-novel-targets-of-stw5-derived-from-a-rat-model
#10
G Ulrich-Merzenich, A Shcherbakova, O Kelber, H Abdel-Aziz
No abstract text is available yet for this article.
December 2016: Planta Medica
https://www.readbyqxmd.com/read/27964758/expression-of-acid-sensing-ion-channels-and-selection-of-reference-genes-in-mouse-and-naked-mole-rat
#11
Laura-Nadine Schuhmacher, Ewan St John Smith
Acid-sensing ion channels (ASICs) are a family of ion channels comprised of six subunits encoded by four genes and they are expressed throughout the peripheral and central nervous systems. ASICs have been implicated in a wide range of physiological and pathophysiological processes: pain, breathing, synaptic plasticity and excitotoxicity. Unlike mice and humans, naked mole-rats do not perceive acid as a noxious stimulus, even though their sensory neurons express functional ASICs, likely an adaptation to living in a hypercapnic subterranean environment...
December 13, 2016: Molecular Brain
https://www.readbyqxmd.com/read/27941930/erk-mediated-nf-%C3%AE%C2%BAb-activation-through-asic1-in-response-to-acidosis
#12
B Chen, J Liu, T-T Ho, X Ding, Y-Y Mo
Acidic microenvironment is a common feature of solid tumors. We have previously shown that neuron specific acid-sensing ion channel 1 (ASIC1) is expressed in breast cancer, and it is responsible for acidosis-induced cellular signaling through AKT, leading to nuclear factor-κB (NF-κB) activation, and cell invasion and metastasis. However, AKT is frequently activated in cancer. Thus, a key question is whether ASIC1-mediated cell signaling still takes place in the cancer cells carrying constitutively active AKT...
December 12, 2016: Oncogenesis
https://www.readbyqxmd.com/read/27935003/a-temperature-ph-and-sugar-triple-stimuli-responsive-nanofluidic-diode
#13
Yu-Bin Zheng, Shuang Zhao, Shuo-Hui Cao, Sheng-Lin Cai, Xiu-Hong Cai, Yao-Qun Li
In this article, we have demonstrated for the first time a triple stimuli-responsive nanofluidic diode that can rectify ionic current under multiple external stimuli including temperature, pH, and sugar. This diode was fabricated by immobilizing poly[2-(dimethylamino)ethyl methacrylate]-co-[4-vinyl phenylboronic acid] (P(DMAEMA-co-VPBA)) onto the wall of a single glass conical nanopore channel via surface-initiator atom transfer radical polymerization (SI-ATRP). The copolymer brushes contain functional groups sensitive to pH, temperature and sugar that can induce charge and configuration change to affect the status of the pore wall...
January 7, 2017: Nanoscale
https://www.readbyqxmd.com/read/27934921/acid-sensing-ion-channels-are-expressed-in-the-ventrolateral-medulla-and-contribute-to-central-chemoreception
#14
Nana Song, Ruijuan Guan, Qian Jiang, Comron J Hassanzadeh, Yuyang Chu, Xiaomei Zhao, Xia Wang, Dawei Yang, Qijun Du, Xiang-Ping Chu, Linlin Shen
The role of acid-sensing ion channels (ASICs) in the ventrolateral medulla (VLM) remains uncertain. Here, we found that ASIC1a and ASIC2 are widely expressed in rat medulla, and the expression level is higher at neonatal stage as compared to adult stage. The two ASIC subunits co-localized in medualla neurons. Furthermore, pH reduction triggered typical ASIC-type currents in the medulla, including the VLM. These currents showed a pH50 value of 6.6 and were blocked by amiloride. Based on their sensitivity to psalmotoxin 1 (PcTx1) and zinc, homomeric ASIC1a and heteromeric ASIC1a/2 channels were likely responsible for acid-mediated currents in the mouse medulla...
December 9, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27924869/asic1a-regulates-insular-long-term-depression-and-is-required-for-the-extinction-of-conditioned-taste-aversion
#15
Wei-Guang Li, Ming-Gang Liu, Shining Deng, Yan-Mei Liu, Lin Shang, Jing Ding, Tsan-Ting Hsu, Qin Jiang, Ying Li, Fei Li, Michael Xi Zhu, Tian-Le Xu
Acid-sensing ion channel 1a (ASIC1a) has been shown to play important roles in synaptic plasticity, learning and memory. Here we identify a crucial role for ASIC1a in long-term depression (LTD) at mouse insular synapses. Genetic ablation and pharmacological inhibition of ASIC1a reduced the induction probability of LTD without affecting that of long-term potentiation in the insular cortex. The disruption of ASIC1a also attenuated the extinction of established taste aversion memory without altering the initial associative taste learning or its long-term retention...
December 7, 2016: Nature Communications
https://www.readbyqxmd.com/read/27923663/pharmacogenetics-of-lithium-effects-on-glomerular-function-in-bipolar-disorder-patients-under-chronic-lithium-treatment-a-pilot-study
#16
Evangelia Eirini Tsermpini, Yanfei Zhang, Paola Niola, Caterina Chillotti, Raffaella Ardau, Alberto Bocchetta, George P Patrinos, Maria Del Zompo, Giovanni Severino, Ming Ta Michael Lee, Alessio Squassina
Bipolar disorder (BD) is a psychiatric disease characterized by alternating episodes of mania and depression. Lithium (Li) represents the mainstay treatment for BD, although a significant proportion of patients shows insufficient or no response. Li is also associated with potentially severe side effects, including renal effects. Several studies reported that Li may induce reduction of glomerular filtration rate (GFR) in patients under long-term treatment. The biological systems and the genetic factors involved in susceptibility to Li-induced renal-side effects have been scarcely explored...
December 5, 2016: Neuroscience Letters
https://www.readbyqxmd.com/read/27922108/corrigendum-astrocytic-acid-sensing-ion-channel-1a-contributes-to-the-development-of-chronic-epileptogenesis
#17
Feng Yang, Xiaolong Sun, Yinxiu Ding, Hui Ma, Tangpeng Ou Yang, Yue Ma, Dong Wei, Wen Li, Tianle Xu, Wen Jiang
No abstract text is available yet for this article.
December 6, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27918554/asic1a-mediates-the-drug-resistance-of-human-hepatocellular-carcinoma-via-the-ca-2-pi3-kinase-akt-signaling-pathway
#18
Yihao Zhang, Ting Zhang, Chao Wu, Quan Xia, Dujuan Xu
Chemotherapy is the main treatment method of patients with advanced liver cancer. However, drug resistance is a serious problem in the treatment of hepatocellular carcinoma (HCC). Acid sensing ion channel 1a (ASIC1a) is a H(+)-gated cation channel; it mediates tumor cell migration and invasion, which suggests that it is involved in the development of malignant tumors. Therefore, we studied the relationship between ASIC1a and drug resistance in human hepatocellular carcinoma. In our study, we found that ASIC1a is highly expressed in human HCC tissue, and that its levels were significantly increased in resistant HCC cells Bel7402/FU and HepG2/ADM...
January 2017: Laboratory Investigation; a Journal of Technical Methods and Pathology
https://www.readbyqxmd.com/read/27896621/distinct-roles-of-asic3-and-trpv1-receptors-in-electroacupuncture-induced-segmental-and-systemic-analgesia
#19
Juanjuan Xin, Yangshuai Su, Zhaokun Yang, Wei He, Hong Shi, Xiaoyu Wang, Ling Hu, Xiaochun Yu, Xianghong Jing, Bing Zhu
Previous studies have demonstrated the effects of different afferent fibers on electroacupuncture (EA)-induced analgesia. However, contributions of functional receptors expressed on afferent fibers to the EA analgesia remain unclear. This study investigates the roles of acid-sensing ion channel 3 (ASIC3) and transient receptor potential vanilloid 1 (TRPV1) receptors in EA-induced segmental and systemic analgesia. Effects of EA at acupoint ST36 with different intensities on the C-fiber reflex and mechanical and thermal pain thresholds were measured among the ASIC3(-/-), TRPV1(-/-), and C57BL/6 mice...
November 28, 2016: Frontiers of Medicine
https://www.readbyqxmd.com/read/27879566/the-effect-of-an-acid-sensing-ion-channels-asics-inhibitor-on-pain-related-behavior-by-nucleus-pulposus-applied-on-the-nerve-root-in-rats
#20
Yoshihiro Kobayashi, Miho Sekiguchi, Shin-Ichi Konno
STUDY DESIGN: Controlled, interventional, animal study. OBJECTIVE: To examine the effect of an inhibitor of acid-sensing ion channel 3 (ASIC3) on pain-related behavior induced by application of the nucleus pulposus (NP) onto the dorsal root ganglion (DRG) in rats. SUMMARY OF BACKGROUND DATA: ASIC3 is associated with acidosis pain in inflamed or ischemic tissues and is expressed in sensory neurons and NP cells. The ASIC3 inhibitor, APETx2, increases the mechanical threshold of pain in models of knee osteoarthritis or postoperative pain...
November 22, 2016: Spine
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