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Acid-sensing ion channels

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https://www.readbyqxmd.com/read/29659564/multiscale-modelization-in-a-small-virus-mechanism-of-proton-channeling-and-its-role-in-triggering-capsid-disassembly
#1
Juan Francisco Viso, Patricia Belelli, Matías Machado, Humberto González, Sergio Pantano, María Julia Amundarain, Fernando Zamarreño, Maria Marta Branda, Diego M A Guérin, Marcelo D Costabel
In this work, we assess a previously advanced hypothesis that predicts the existence of ion channels in the capsid of small and non-enveloped icosahedral viruses. With this purpose we examine Triatoma Virus (TrV) as a case study. This virus has a stable capsid under highly acidic conditions but disassembles and releases the genome in alkaline environments. Our calculations range from a subtle sub-atomic proton interchange to the dismantling of a large-scale system representing several million of atoms. Our results provide structure-based explanations for the three roles played by the capsid to enable genome release...
April 16, 2018: PLoS Computational Biology
https://www.readbyqxmd.com/read/29643714/combined-effect-of-acid-sensing-ion-channel-3-and-transient-receptor-potential-vanilloid-1-gene-polymorphisms-on-blood-pressure-variations-in-taiwanese
#2
Leay-Kiaw Er, Ming-Sheng Teng, Semon Wu, Lung-An Hsu, I-Shiang Tzeng, Ching-Feng Cheng, Hsin-I Chang, Hsin-Hua Chou, Yu-Lin Ko
Objectives: Both acid-sensing ion channel acid-sensing ion channel 3 (ASIC3) and transient receptor potential vanilloid 1 (TRPV1) have been proposed to be involved in the pathophysiology of hypertension. Common colocalization of ASIC3 and TRPV1 channels in the same sensory neuron has been reported. We aimed to study the combined ASIC3 and TRPV1 gene polymorphisms in the risk of hypertension. Materials and Methods: To test the statistical association between genetic polymorphisms of the ASIC3 and TRPV1 genes and blood pressure (BP) variations in Taiwanese, 551 unrelated individuals (286 men and 265 women) having routine health examinations were recruited...
January 2018: Ci Ji Yi Xue za Zhi, Tzu-chi Medical Journal
https://www.readbyqxmd.com/read/29643227/voltage-and-ph-sensing-by-the-voltage-gated-proton-channel-h-v-1
#3
REVIEW
Thomas E DeCoursey
Voltage-gated proton channels are unique ion channels, membrane proteins that allow protons but no other ions to cross cell membranes. They are found in diverse species, from unicellular marine life to humans. In all cells, their function requires that they open and conduct current only under certain conditions, typically when the electrochemical gradient for protons is outwards. Consequently, these proteins behave like rectifiers, conducting protons out of cells. Their activity has electrical consequences and also changes the pH on both sides of the membrane...
April 2018: Journal of the Royal Society, Interface
https://www.readbyqxmd.com/read/29627444/inhalational-anesthetics-accelerate-desensitization-of-acid-sensing-ion-channels
#4
Linda Lehmke, Mark Coburn, Manfred Möller, Rosmarie Blaumeiser-Debarry, Pia Lenzig, Dominik Wiemuth, Stefan Gründer
Acid-sensing ion channels (ASICs) are neuronal Na+ channels that are activated by extracellular acidification. Inhibiting ASICs is neuroprotective in mouse models of ischemic stroke. As inhalational anesthetics interact with many ion channels and as some of them have neuroprotective effects, we hypothesized that inhalational anesthetics modulate ASICs. We expressed different homo- and heteromeric ASICs heterologously in Xenopus oocytes. We co-applied with acidic pH the halogenated inhalational anesthetics sevoflurane, desflurane, and isoflurane and the noble gases xenon and argon at concentrations that are roughly equivalent to their minimal alveolar concentrations and analyzed their effect on current kinetics and amplitude...
April 5, 2018: Neuropharmacology
https://www.readbyqxmd.com/read/29617678/increased-asics-expression-via-the-camkii-creb-pathway-in-a-novel-mouse-model-of-trigeminal-pain
#5
Yan Wang, Xiujuan Fu, Lifang Huang, Xi Wang, Zuneng Lu, Fan Zhu, Zheman Xiao
BACKGROUND/AIMS: Migraine is a disabling condition that severely impacts socioeconomic function and quality of life. The focus of this study was to develop a mouse model of trigeminal pain that mimics migraine. METHODS: After undergoing dural cannulation surgery, mice were treated with repeated dural doses of an acidic solution to induce trigeminal pain. RESULTS: The method elicited intermittent, head-directed wiping and scratching as well as the expression of both the c-FOS gene in the spinal trigeminal nucleus caudalis and calcitonin gene related peptide (CGRP) in the periaqueductal grey matter...
March 28, 2018: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29604058/mutations-in-the-voltage-sensing-domain-affect-the-alternative-ion-permeation-pathway-in-the-trpm3-channel
#6
Katharina Held, Fabian Gruss, Vincenzo Davide Aloi, Annelies Janssens, Chris Ulens, Thomas Voets, Joris Vriens
Transient receptor potential (TRP) channels are cationic channels involved in a broad array of functions, including homeostasis, motility and sensory functions. TRP channel subunits consist of six transmembrane segments (S1-S6), and form tetrameric channels with a central pore formed by the region encompassing S5 and S6. Recently, evidence was provided for the existence of an alternative ion permeation pathway in TRPM3, which allows large inward currents upon hyperpolarization independently from the central pore...
March 31, 2018: Journal of Physiology
https://www.readbyqxmd.com/read/29595330/neuroprotective-effects-of-psalmotoxin-1-an-acid-sensing-ion-channel-asic-inhibitor-in-ischemia-reperfusion-in-mouse-eyes
#7
Adnan Dibas, Cameron Millar, Abraham Al-Farra, Thomas Yorio
PURPOSE: The purpose of the current study is to assess changes in the expression of Acid-Sensing Ion Channel (ASIC)1a and ASIC2 in retinal ganglion cells (RGCs) after retinal ischemia and reperfusion (I/R) injury and to test if inhibition of ASIC1a provides RGC neuroprotection. METHODS: Transient ischemia was induced in one eye of C57BL/6 mice by raising intraocular pressure to 120 mmHg for 60 min followed by retinal reperfusion by restoring normal pressure. RGC function was measured by Pattern electroretinography (PERG)...
March 29, 2018: Current Eye Research
https://www.readbyqxmd.com/read/29584803/involvement-of-acid-sensing-ion-channel-1a-in-gastric-carcinoma-cell-migration-and-invasion
#8
Xin Chen, Xue Sun, Zhe Wang, Xiaojun Zhou, Lu Xu, Feng'e Li, Xingding Zhang, Ji'an Pan, Lin Qi, Haixin Qian, Zhongqi Mao
Acidic microenvironment, particularly acid-sensing ion channel 1a (ASIC1a), has been reported to promote carcinoma cell proliferation as well as migration. In this study, we explored the effect of ASIC1a on migration and invasion of gastric carcinoma (GC). ASIC1a expression levels were examined in paired GC and adjacent normal tissues from 16 patients by immunohistochemistry. Reverse transcription real-time PCR and immunoblotting were conducted to assess the ASIC1a expression levels in the GC cell line AGS after transfection with ASIC1a small hairpin RNA (shRNA)...
March 23, 2018: Acta Biochimica et Biophysica Sinica
https://www.readbyqxmd.com/read/29574226/role-of-asic1a-in-a%C3%AE-induced-synaptic-alterations-in-the-hippocampus
#9
D Mango, R Nisticò
Acid-sensing ion channels (ASICs) are widely expressed in the mammalian central nervous system where they play a key role in synaptic transmission and in specific forms of memory. On the other hand, ASICs can be persistently active under pathological conditions contributing to neuronal damage in ischemic stroke, brain trauma, epilepsy and Parkinson's disease. However, to date no experimental evidence has linked ASICs to Alzheimer's disease (AD). Aim of the present work was to investigate, in CA1 pyramidal neurons, the possible involvement of ASIC1a in the Aβ-mediated effect on metabotropic glutamate (mGlu) receptor dependent transmission...
March 21, 2018: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/29568513/assaying-sensory-ciliopathies-using-calcium-biosensor-expression-in-zebrafish-ciliated-olfactory-neurons
#10
Judith G M Bergboer, Cameron Wyatt, Christina Austin-Tse, Emre Yaksi, Iain A Drummond
Background: Primary cilia mediate signal transduction by acting as an organizing scaffold for receptors, signalling proteins and ion channels. Ciliated olfactory sensory neurons (OSNs) organize olfactory receptors and ion channels on cilia and generate a calcium influx as a primary signal in odourant detection. In the zebrafish olfactory placode, ciliated OSNs and microvillus OSNs constitute the major OSN cell types with distinct odourant sensitivity. Methods: Using transgenic expression of the calcium biosensor GCaMP5 in OSNs, we analysed sensory cilia-dependent odour responses in live zebrafish, at individual cell resolution...
2018: Cilia
https://www.readbyqxmd.com/read/29566331/heteroarylguanidines-as-allosteric-modulators-of-asic1a-and-asic3-channels
#11
Omar Alijevic, Hassan Hammoud, Anand Vaithia, Viktor Trendafilov, Maud Bollenbach, Martine Schmitt, Frederic Bihel, Stephan Kellenberger
Acid-sensing ion channels (ASICs) are neuronal Na+ -selective ion channels that open in response to a rapid extracellular acidification. They are involved in pain, fear, learning and neurodegeneration after ischemic stroke. 2-Guanidine-4-methylquinazoline (GMQ) was recently discovered as the first nonproton activator of ASIC3. GMQ is of interest as a gating modifier and pore blocker of ASICs. It has however a low potency, and exerts opposite effects on ASIC1a and ASIC3. To further explore the molecular mechanisms of GMQ action, we have used the guanidinium moiety of GMQ as a scaffold and tested the effects of different GMQ derivatives on the ASIC pH dependence and maximal current...
March 22, 2018: ACS Chemical Neuroscience
https://www.readbyqxmd.com/read/29562233/structural-insights-into-the-voltage-and-phospholipid-activation-of-the-mammalian-tpc1-channel
#12
Ji She, Jiangtao Guo, Qingfeng Chen, Weizhong Zeng, Youxing Jiang, Xiao-Chen Bai
The organellar two-pore channel (TPC) functions as a homodimer, in which each subunit contains two homologous Shaker-like six-transmembrane (6-TM)-domain repeats. TPCs belong to the voltage-gated ion channel superfamily and are ubiquitously expressed in animals and plants. Mammalian TPC1 and TPC2 are localized at the endolysosomal membrane, and have critical roles in regulating the physiological functions of these acidic organelles. Here we present electron cryo-microscopy structures of mouse TPC1 (MmTPC1)-a voltage-dependent, phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2 )-activated Na+ -selective channel-in both the apo closed state and ligand-bound open state...
April 5, 2018: Nature
https://www.readbyqxmd.com/read/29561183/asic3-fine-tunes-bladder-sensory-signaling
#13
Nicola Montalbetti, James G Rooney, Allison L Marciszyn, Marcelo D Carattino
Acid-sensing ion channels (ASICs) are trimeric proton-activated cation selective neuronal channels that are considered to play important roles in mechanosensation and nociception. Here we investigated the role of ASIC3, a subunit primarily expressed in sensory neurons, in bladder sensory signaling and function. We found that extracellular acidification evokes a transient increase in current, consistent with the kinetics of activation and desensitization of ASICs, in ~ 25% of the bladder sensory neurons harvested from both wild type (WT) and ASIC3 knockout (KO) mice...
March 21, 2018: American Journal of Physiology. Renal Physiology
https://www.readbyqxmd.com/read/29555470/acute-stress-enhances-learning-and-memory-by-activating-acid-sensing-ion-channels-in-rats
#14
Shunjie Ye, Rong Yang, Qiuju Xiong, Youhua Yang, Lianying Zhou, Yeli Gong, Changlei Li, Zhenhan Ding, Guohai Ye, Zhe Xiong
Acute stress has been shown to enhance learning and memory ability, predominantly through the action of corticosteroid stress hormones. However, the valuable targets for promoting learning and memory induced by acute stress and the underlying molecular mechanisms remain unclear. Acid-sensing ion channels (ASICs) play an important role in central neuronal systems and involves in depression, synaptic plasticity and learning and memory. In the current study, we used a combination of electrophysiological and behavioral approaches in an effort to explore the effects of acute stress on ASICs...
April 15, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29549622/targeted-acid-sensing-ion-channel-therapies-for-migraine
#15
REVIEW
Nazia Karsan, Eric B Gonzales, Gregory Dussor
Acid-sensing ion channels (ASICs) are a family of ion channels, consisting of four members; ASIC1 to 4. These channels are sensitive to changes in pH and are expressed throughout the central and peripheral nervous systems-including brain, spinal cord, and sensory ganglia. They have been implicated in a number of neurological conditions such as stroke and cerebral ischemia, traumatic brain injury, and epilepsy, and more recently in migraine. Their expression within areas of interest in the brain in migraine, such as the hypothalamus and PAG, their demonstrated involvement in preclinical models of meningeal afferent signaling, and their role in cortical spreading depression (the electrophysiological correlate of migraine aura), has enhanced research interest into these channels as potential therapeutic targets in migraine...
March 16, 2018: Neurotherapeutics: the Journal of the American Society for Experimental NeuroTherapeutics
https://www.readbyqxmd.com/read/29513651/gating-mechanisms-of-acid-sensing-ion-channels
#16
Nate Yoder, Craig Yoshioka, Eric Gouaux
Acid-sensing ion channels (ASICs) are trimeric, proton-gated and sodium-selective members of the epithelial sodium channel/degenerin (ENaC/DEG) superfamily of ion channels and are expressed throughout vertebrate central and peripheral nervous systems. Gating of ASICs occurs on a millisecond time scale and the mechanism involves three conformational states: high pH resting, low pH open and low pH desensitized. Existing X-ray structures of ASIC1a describe the conformations of the open and desensitized states, but the structure of the high pH resting state and detailed mechanisms of the activation and desensitization of the channel have remained elusive...
March 7, 2018: Nature
https://www.readbyqxmd.com/read/29477572/multiple-regulatory-actions-of-2-guanidine-4-methylquinazoline-gmq-an-agonist-of-acid-sensing-ion-channel-type-3-on-ionic-currents-in-pituitary-gh-3-cells-and-in-olfactory-sensory-rolf-b1-t-neurons
#17
Edmund Cheung So, Yingwei Wang, Li Qun Yang, Kenny Hsu So, Yi-Ching Lo, Sheng-Nan Wu
GMQ (2-guanidine-4-methylquinazoline or N-(4-methyl-2-quinazolinyl)-guanidine hydrochloride), an agonist of acid-sensing ion channel type 3, has been increasingly used for in vivo studies of alternations in nociceptic behavior. In this study, we tried to investigate whether GMQ has any possible effect on other types of ion channels. Addition of GMQ to pituitary GH3 cells raised the amplitude of Ca2+ -activated K+ currents (IK(Ca) ), which was reversed by verruculogen or PF1022A, but not by TRAM-39. Under inside-out current recordings, addition of GMQ into bath enhanced the probability of large-conductance Ca2+ -activated K+ (BKCa ) channels with an EC50 value of 0...
February 23, 2018: Biochemical Pharmacology
https://www.readbyqxmd.com/read/29477040/effects-of-creatine-supplementation-on-nociception-in-young-male-and-female-mice
#18
Haydee Izurieta Munoz, Eric B Gonzales, Nathalie Sumien
BACKGROUND: The objective of this study was to evaluate creatine as an anti-nociceptive compound in an animal model of thermal and inflammatory pain. Creatine has the structural potential to interact with acid-sensing ion channels (ASIC), which have been involved in pain sensation modulation. The hypothesis evaluated in this study was that creatine will interact with ASICs leading to decreased nociception. METHODS: Male and female C57BL/6J mice were fed with either a control diet or the control diet supplemented with creatine (6...
November 11, 2017: Pharmacological Reports: PR
https://www.readbyqxmd.com/read/29474404/role-of-acid-sensing-ion-channels-in-hypoxia-and-hypercapnia-induced-ventilatory-responses
#19
Neil D Detweiler, Kenneth G Vigil, Thomas C Resta, Benjimen R Walker, Nikki L Jernigan
Previous reports indicate roles for acid-sensing ion channels (ASICs) in both peripheral and central chemoreception, but the contributions of ASICs to ventilatory drive in conscious, unrestrained animals remain largely unknown. We tested the hypotheses that ASICs contribute to hypoxic- and hypercapnic-ventilatory responses. Blood samples taken from conscious, unrestrained mice chronically instrumented with femoral artery catheters were used to assess arterial O2, CO2, and pH levels during exposure to inspired gas mixtures designed to cause isocapnic hypoxemia or hypercapnia...
2018: PloS One
https://www.readbyqxmd.com/read/29447005/human-asic1a-mediates-stronger-acid-induced-responses-as-compared-with-mouse-asic1a
#20
Yuanyuan Xu, Yu-Qing Jiang, Ce Li, Mindi He, W George Rusyniak, Naga Annamdevula, Juan Ochoa, Silas J Leavesley, Jiangping Xu, Thomas C Rich, Mike T Lin, Xiang-Ming Zha
Acid-sensing ion channels (ASICs) are the major proton receptor in the brain and a key mediator of acidosis-induced neuronal injuries in disease. Most of published data on ASIC function came from studies performed in mice, and relatively little is known about potential differences between human and mouse ASICs (hASIC and mASIC, respectively). This information is critical for us to better interpret the functional importance of ASICs in human disease. Here, we examined the expression of ASICs in acutely resected human cortical tissue...
February 15, 2018: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
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