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Acid-sensing ion channels

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https://www.readbyqxmd.com/read/28212011/a-fluorescent-anionic-mof-with-zn4-trz-2-chain-for-highly-selective-visual-sensing-of-contaminants-cr-iii-ion-and-tnp
#1
Xiao-Xia Jia, Ru-Xin Yao, Fu-Qiang Zhang, Xian-Ming Zhang
Heavy-metal ions and nitroaromatic substances are highly toxic and harmful to human health and the ecological environment. It is an urgent issue to selectively detect and capture these toxic substances. By introducing the triazole ligand to the π-conjugated aromatic carboxylate system and borrowing the organic template open framework idea, a stable fluorescent framework [Me2NH2]4[Zn6(qptc)3(trz)4]·6H2O (1) (H4qptc = terphenyl-2,5,2'5'-tetracarboxylic acid, trz = 1,2,4-triazole) has been successfully synthesized, which features Zn4(trz)2 chain-based 3D anionic structure with channels filled by [Me2NH2](+) cations...
February 17, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/28211811/acidity-and-acid-sensing-ion-channels-in-the-normal-and-alzheimer-s-disease-brain
#2
Eric B Gonzales, Nathalie Sumien
Alzheimer's disease prevalence has reached epidemic proportion with very few treatment options, which are associated with a multitude of side effects. A potential avenue of research for new therapies are protons, and their associated receptor: acid-sensing ion channels (ASIC). Protons are often overlooked neurotransmitters, and proton-gated currents have been identified in the brain. Furthermore, ASICs have been determined to be crucial for proper brain function. While there is more work to be done, this review is intended to highlight protons as neurotransmitters and their role along with the role of ASICs within physiological functioning of the brain...
February 15, 2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/28193786/bile-acids-potentiate-proton-activated-currents-in-xenopus-laevis-oocytes-expressing-human-acid-sensing-ion-channel-asic1a
#3
Alexandr V Ilyaskin, Alexei Diakov, Christoph Korbmacher, Silke Haerteis
Acid-sensing ion channels (ASICs) are nonvoltage-gated sodium channels transiently activated by extracellular protons and belong to the epithelial sodium channel (ENaC)/Degenerin (DEG) family of ion channels. Bile acids have been shown to activate two members of this family, the bile acid-sensitive ion channel (BASIC) and ENaC. To investigate whether bile acids also modulate ASIC function, human ASIC1a was heterologously expressed in Xenopus laevis oocytes. Exposing oocytes to tauro-conjugated cholic (t-CA), deoxycholic (t-DCA), and chenodeoxycholic (t-CDCA) acid at pH 7...
February 2017: Physiological Reports
https://www.readbyqxmd.com/read/28187208/respiratory-virus-infection-up-regulates-trpv1-trpa1-and-asics3-receptors-on-airway-cells
#4
Shadia Omar, Rebecca Clarke, Haniah Abdullah, Clare Brady, John Corry, Hanagh Winter, Olivier Touzelet, Ultan F Power, Fionnuala Lundy, Lorcan P A McGarvey, S Louise Cosby
Receptors implicated in cough hypersensitivity are transient receptor potential vanilloid 1 (TRPV1), transient receptor potential cation channel, Subfamily A, Member 1 (TRPA1) and acid sensing ion channel receptor 3 (ASIC3). Respiratory viruses, such as respiratory syncytial virus (RSV) and measles virus (MV) may interact directly and/or indirectly with these receptors on sensory nerves and epithelial cells in the airways. We used in vitro models of sensory neurones (SHSY5Y or differentiated IMR-32 cells) and human bronchial epithelium (BEAS-2B cells) as well as primary human bronchial epithelial cells (PBEC) to study the effect of MV and RSV infection on receptor expression...
2017: PloS One
https://www.readbyqxmd.com/read/28181561/peripheral-sensory-neuron-injury-contributes-to-neuropathic-pain-in-experimental-autoimmune-encephalomyelitis
#5
I-Ching Wang, Chen-Yen Chung, Fang Liao, Chih-Cheng Chen, Cheng-Han Lee
Multiple sclerosis (MS)-induced neuropathic pain deteriorates quality of life in patients but is often refractory to treatment. In experimental autoimmune encephalomyelitis (EAE), a rodent model of MS, animals develop neuropathy and inflammation-induced tissue acidosis, which suggests the involvement of acid-sensing ion channels (ASICs). Also, peripheral neuropathy is reported in MS patients. However, the involvement of the peripheral nervous system (PNS) in MS neuropathic pain remains elusive. This study investigated the contribution of ASICs and peripheral neuropathy in MS-induced neuropathic pain...
February 9, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28159907/acid-sensing-ion-channels-activated-by-evoked-released-protons-modulate-synaptic-transmission-at-the-mouse-calyx-of-held-synapse
#6
Carlota González-Inchauspe, Francisco J Urbano, Mariano N Di Guilmi, Osvaldo D Uchitel
: Acid-sensing ion channels (ASICs) regulate synaptic activities and play important roles in neurodegenerative diseases. We found that these channels can be activated in neurons of the medial nucleus of the trapezoid body (MNTB) of the auditory system in the CNS. A drop in extracellular pH induces transient inward currents (IASIC) in postsynaptic MNTB neurons from wild type (WT) mice. The inhibition of IASIC by psalmotoxin-1 (PcTx1) and the absence of these currents in knock out mice for ASIC-1a subunit (ASIC1a(-/-)) suggest that homomeric ASIC-1a channels are mediating these currents in MNTB neurons...
February 3, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/28137639/acid-sensing-ion-channel-1a-is-required-for-mglu-receptor-dependent-long-term-depression-in-the-hippocampus
#7
D Mango, E Braksator, G Battaglia, S Marcelli, N B Mercuri, M Feligioni, F Nicoletti, Z I Bashir, R Nisticò
Acid-sensing ion channels (ASICs), members of the degenerin/epithelial Na(+) channel superfamily, are widely distributed in the mammalian nervous system. ASIC1a is highly permeable to Ca(2+) and are thought to be important in a variety of physiological processes, including synaptic plasticity, learning and memory. To further understand the role of ASIC1a in synaptic transmission and plasticity, we investigated metabotropic glutamate (mGlu) receptor-dependent long-term depression (LTD) in the hippocampus. We found that ASIC1a channels mediate a component of LTD in P30-40 animals, since the ASIC1a selective blocker psalmotoxin-1 (PcTx1) reduced the magnitude of LTD induced by application of the group I mGlu receptor agonist (S)-3,5-Dihydroxyphenylglycine (DHPG) or induced by paired-pulse low frequency stimulation (PP-LFS)...
January 27, 2017: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/28121219/amiloride-sensitive-cation-channel-2-genotype-affects-the-response-to-a-carbon-dioxide-panic-challenge
#8
Nicole K Leibold, Daniel LA van den Hove, Wolfgang Viechtbauer, Gunter Kenis, Liesbet Goossens, Iris Lange, Inge Knuts, Hubert J Smeets, Inez Myin-Germeys, Harry Wm Steinbusch, Koen Rj Schruers
Until recently, genetic research into panic disorder (PD) has had only limited success. Inspired by rodent research, demonstrating that the acid-sensing ion channel 1a (ASIC1a) is critically involved in the behavioral fear response to carbon dioxide (CO2) exposure, variants in the human homologue gene amiloride-sensitive cation channel 2 (ACCN2) were shown to be associated with PD. However, the relationship between changes in brain pH and ACCN2, as done in rodents by CO2 exposure, has not been investigated yet in humans...
January 1, 2017: Journal of Psychopharmacology
https://www.readbyqxmd.com/read/28117962/acidotoxicity-via-asic1a-mediates-cell-death-during-oxygen-glucose-deprivation-and-abolishes-excitotoxicity
#9
Saurav Bhowmick, Jeanette T Moore, Daniel L Kirschner, Mary C Curry, Emily G Westbrook, Brian T Rasley, Kelly L Drew
Ischemia-reperfusion (I/R) injury is associated with a complex and multifactorial cascade of events involving excitotoxicity, acidotoxicity, and ionic imbalance. While it is known that acidosis occurs concomitantly with glutamate-mediated excitotoxicity during brain ischemia, it remains elusive, how acidosis-mediated acidotoxicity interacts with glutamate-mediated excitotoxicity. Here, we investigated the effect of acidosis on glutamate-mediated excitotoxicity in acute hippocampal slices. We tested the hypothesis that mild acidosis protects against I/R injury via modulation of NMDAR, but produces injury via activation of acid sensing ion channels (ASIC1a)...
January 24, 2017: ACS Chemical Neuroscience
https://www.readbyqxmd.com/read/28111260/down-regulation-of-asic1-suppressed-gastric-cancer-via-inhibiting-autophagy
#10
Qiong Zhang, Shiwu Wu, Jinhai Zhu, Damin Chai, Huaiyong Gan
As autophagy has anti-apoptosis effect and accelerates cell survival, many studies start to target autophagy as a therapeutic strategy for cancer. Acid-sensing ion channels (ASICs) was reported to activate autophagy. However, whether ASICs can regulate gastric cancer through autophagy is unknown. The differentially expressed genes in normal gastric tissue and gastric cancer tissue in patients were investigated by RNA-seq. Expression of ASIC1 and autophagy related 5 (ATG5) was further confirmed by real-time PCR...
January 19, 2017: Gene
https://www.readbyqxmd.com/read/28103434/analgesic-effect-of-quetiapine-in-a-mouse-model-of-cancer-induced-bone-pain
#11
Mi Hwa Heo, Jin Young Kim, Ilseon Hwang, Eunyoung Ha, Keon Uk Park
Background/Aims: Cancer-induced bone pain (CIBP) is one of the most common pains in patients with advanced neoplasms. Because of treatment-associated side effects, more than half of cancer patients are reported to have inadequate and undermanaged pain control. New mechanism-based therapies must be developed to reduce cancer pain. Quetiapine is a commonly used atypical antipsychotic drug. We report a study of the potential analgesic effects of quetiapine in a mouse model of CIBP and examine the mechanism of bone pain by analyzing the expression of various nociceptors...
January 20, 2017: Korean Journal of Internal Medicine
https://www.readbyqxmd.com/read/28103019/highly-water-stable-novel-lanthanide-wheel-cluster-organic-frameworks-featuring-coexistence-of-hydrophilic-cagelike-chambers-and-hydrophobic-nanosized-channels
#12
Yuan-Yuan Zhou, Yang Shi, Bing Geng, Qi-Bing Bo
In attempts to investigate the potential luminescent sensing materials for sensitive detection of environmental pollutants, a new family of lanthanide wheel cluster organic frameworks (Ln-WCOFs) UJN-Ln4 has been constructed by employing one of the cycloalkane dicarboxylic acid derivatives. Adopting different conformations, the ligand links Ln4 second building units (SBUs) and Ln24 tertiary building units (TBUs) to form a unique wheel cluster layer-pillared 3D framework featuring the coexistence of hydrophobic nanosized channels and trigonal antiprism arrays with hydrophilic cagelike chambers...
February 1, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28072525/anionic-lanthanide-mofs-as-a-platform-for-iron-selective-sensing-systematic-color-tuning-and-efficient-nanoparticle-catalysis
#13
Ya-Pan Wu, Guo-Wang Xu, Wen-Wen Dong, Jun Zhao, Dong-Sheng Li, Jian Zhang, Xianhui Bu
New porous anionic Ln-MOFs, namely, [Me2NH2][Ln(CPA)2(H2O)2] (Ln = Eu, Gd), have been prepared through the self-assembly of 5-(4-carboxy phenyl)picolinic acid (H2CPA) and lanthanide ions. They feature open anionic frameworks with 1-D hydrophilic channels and exchangeable dimethylamine ions. The Eu phase could detect Fe(3+) ions with high selectivity and sensitivity in either aqueous solution or biological condition. The ratios of lanthanide ions on this structure platform could be rationally tuned to not only achieve dichromatic emission colors with linear correlation but also attain three primary colors (RGB) and even white light with favorable correlated color temperature...
January 10, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/28062311/trpa1-and-trpv1-antagonists-do-not-inhibit-human-acidosis-induced-pain
#14
Matthias G Schwarz, Barbara Namer, Peter W Reeh, Michael J M Fischer
: Acidosis occurs in a variety of pathophysiological and painful conditions where it is thought to excite or contribute to excitation of nociceptive neurons. Despite potential clinical relevance the principal receptor for sensing acidosis is unclear, but several receptors have been proposed. We investigated the contribution of the acid-sensing ion channels, transient receptor potential vanilloid type 1 (TRPV1) and transient receptor potential ankyrin type 1 (TRPA1) to peripheral pain signaling...
January 3, 2017: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/28030818/asic1-promotes-differentiation-of-neuroblastoma-by-negatively-regulating-notch-signaling-pathway
#15
Mingli Liu, Koichi Inoue, Tiandong Leng, An Zhou, Shanchun Guo, Zhi-Gang Xiong
In neurons, up-regulation of Notch activity either inhibits neurite extension or causes retraction of neurites. Conversely, inhibition of Notch1 facilitates neurite extension. Acid-sensing ion channels (ASICs) are a family of proton-gated cation channels, which play critical roles in synaptic plasticity, learning and memory and spine morphogenesis. Our pilot proteomics data from ASIC1a knock out mice implicated that ASIC1a may play a role in regulating Notch signaling, therefore, we explored whether or not ASIC1a regulates neurite growth during neuronal development through Notch signaling...
January 31, 2017: Oncotarget
https://www.readbyqxmd.com/read/28028533/extracellular-electrical-recording-of-ph-triggered-bursts-in-c6-glioma-cell-populations
#16
Paulo R F Rocha, Maria C R Medeiros, Ulrike Kintzel, Johannes Vogt, Inês M Araújo, Ana L G Mestre, Volker Mailänder, Paul Schlett, Melanie Dröge, Leonid Schneider, Fabio Biscarini, Dago M de Leeuw, Henrique L Gomes
Glioma patients often suffer from epileptic seizures because of the tumor's impact on the brain physiology. Using the rat glioma cell line C6 as a model system, we performed long-term live recordings of the electrical activity of glioma populations in an ultrasensitive detection method. The transducer exploits large-area electrodes that maximize double-layer capacitance, thus increasing the sensitivity. This strategy allowed us to record glioma electrical activity. We show that although glioma cells are nonelectrogenic, they display a remarkable electrical burst activity in time...
December 2016: Science Advances
https://www.readbyqxmd.com/read/28003157/asic-channel-inhibition-enhances-excitotoxic-neuronal-death-in-an-in-vitro-model-of-spinal-cord-injury
#17
Graciela L Mazzone, Priyadharishini Veeraraghavan, Carlota Gonzalez-Inchauspe, Andrea Nistri, Osvaldo D Uchitel
In the spinal cord high extracellular glutamate evokes excitotoxic damage with neuronal loss and severe locomotor impairment. During the cell dysfunction process, extracellular pH becomes acid and may activate acid-sensing ion channels (ASICs) which could be important contributors to neurodegenerative pathologies. Our previous studies have shown that transient application of the glutamate analog kainate (KA) evokes delayed excitotoxic death of spinal neurons, while white matter is mainly spared. The present goal was to enquire if ASIC channels modulated KA damage in relation to locomotor network function and cell death...
December 19, 2016: Neuroscience
https://www.readbyqxmd.com/read/27989169/multifunctional-luminescent-eu-iii-based-metal-organic-framework-for-sensing-methanol-and-detection-and-adsorption-of-fe-iii-ions-in-aqueous-solution
#18
Jian Wang, Min Jiang, Ling Yan, Ren Peng, Mengjie Huangfu, Xinxin Guo, Yang Li, Pengyan Wu
A novel lanthanide-organic framework (Eu-HODA), consisting of 2,2',3,3'-oxidiphthalic acids as efficient sensitizing units, is assembled and characterized. Eu-HODA features rare chiral helical channels despite the achiral nature of H4ODA. It is found that this MOF shows a unique luminescent response to methanol, in contrast to n-propanol and ethanol. Eu-HODA reveals a turn-off luminescence switching initiated by acetone molecules with an EC50 of 0.03 vol %, which is below the occupational exposure limit of acetone stipulated by the American Conference of Governmental Industrial Hygienists...
December 19, 2016: Inorganic Chemistry
https://www.readbyqxmd.com/read/27983655/fabrication-of-a-horizontal-and-a-vertical-large-surface-area-nanogap-electrochemical-sensor
#19
Jules L Hammond, Mark C Rosamond, Siva Sivaraya, Frank Marken, Pedro Estrela
Nanogap sensors have a wide range of applications as they can provide accurate direct detection of biomolecules through impedimetric or amperometric signals. Signal response from nanogap sensors is dependent on both the electrode spacing and surface area. However, creating large surface area nanogap sensors presents several challenges during fabrication. We show two different approaches to achieve both horizontal and vertical coplanar nanogap geometries. In the first method we use electron-beam lithography (EBL) to pattern an 11 mm long serpentine nanogap (215 nm) between two electrodes...
December 14, 2016: Sensors
https://www.readbyqxmd.com/read/27976056/pain-sensations-in-gastro-esophageal-reflux-disease-may-be-mediated-by-acid-sensing-ion-channels-evidence-for-novel-targets-of-stw5-derived-from-a-rat-model
#20
G Ulrich-Merzenich, A Shcherbakova, O Kelber, H Abdel-Aziz
No abstract text is available yet for this article.
December 2016: Planta Medica
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