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https://www.readbyqxmd.com/read/29233538/borrelia-burgdorferi-serology-and-diagnosis-of-lyme-disease-in-the-healthcare-area-of-santiago-de-compostela-galicia-spain-2006-2016
#1
Mercedes Treviño Castellano, Daniel Navarro de la Cruz, Rocio Trastoy Pena
No abstract text is available yet for this article.
December 9, 2017: Medicina Clínica
https://www.readbyqxmd.com/read/29232415/serological-detection-of-tick-borne-relapsing-fever-in-texan-domestic-dogs
#2
Maria D Esteve-Gasent, Chloe B Snell, Shakirat A Adetunji, Julie Piccione
Tick-Borne Relapsing Fever (TBRF) is caused by spirochetes in the genus Borrelia. Very limited information exists on the incidence of this disease in humans and domestic dogs in the United States. The main objective of this study is to evaluate exposure of dogs to Borrelia turicatae, a causative agent of TBRF, in Texas. To this end, 878 canine serum samples were submitted to Texas A&M Veterinary Medical Diagnostic Laboratory from October 2011 to September 2012 for suspected tick-borne illnesses. The recombinant Borrelial antigen glycerophosphodiester phosphodiesterase (GlpQ) was expressed, purified, and used as a diagnostic antigen in both ELISA assays and Immunoblot analysis...
2017: PloS One
https://www.readbyqxmd.com/read/29231910/-clinical-pictures-of-borreliosis
#3
EDITORIAL
Tadeusz Płusa
Lyme disease occurs in a variety of clinical manifestations, ranging from skin lesions, through musculoskeletal, neurological, and cardiac syndrome, to severe irreversible lesions. Borrelia burgdorferi's organotropy has an impact on the development of the disease. In initial management, it is important to implement effective treatment to prevent further progression of infection. Dominant skin lesions should be differentiated in detail. In the form of disseminated disease complex of clinical syndromes is observed but it requires of confirmation in immunoassays...
November 23, 2017: Polski Merkuriusz Lekarski: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/29228208/advances-in-serodiagnostic-testing-for-lyme-disease-are-at-hand
#4
John A Branda, Barbara A Body, Jeff Boyle, Bernard M Branson, Raymond J Dattwyler, Erol Fikrig, Noel J Gerald, Maria Gomes-Solecki, Martin Kintrup, Michel Ledizet, Andrew E Levin, Michael Lewinski, Lance A Liotta, Adriana Marques, Paul S Mead, Emmanuel F Mongodin, Segaran Pillai, Prasad Rao, William H Robinson, Kristian M Roth, Martin E Schriefer, Thomas Slezak, Jessica Snyder, Allen C Steere, Jan Witkowski, Susan J Wong, Steven E Schutzer
The cause of Lyme disease, Borrelia burgdorferi, was discovered in 1983. A 2-tiered testing protocol was established for serodiagnosis in 1994, involving an enzyme immunoassay (EIA) or indirect fluorescence antibody, followed (if reactive) by immunoglobulin M and immunoglobulin G Western immunoblots. These assays were prepared from whole-cell cultured B. burgdorferi, lacking key in vivo expressed antigens and expressing antigens that can bind non-Borrelia antibodies. Additional drawbacks, particular to the Western immunoblot component, include low sensitivity in early infection, technical complexity, and subjective interpretation when scored by visual examination...
December 7, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29225980/early-disseminated-lyme-disease-with-carditis-complicated-by-posttreatment-lyme-disease-syndrome
#5
Cheryl Novak, Andrew Harrison, John Aucott
Lyme disease is an infectious disease caused by the bacterium Borrelia burgdorferi. When untreated, infection may spread to the heart, nervous system, and joints. Cardiac involvement usually manifests as abnormalities of the conduction system and bradycardia. Treatment of Lyme disease is generally effective, with a subset of patients experiencing persistent, sometimes long-term symptoms called posttreatment Lyme disease syndrome.
2017: Case Reports in Infectious Diseases
https://www.readbyqxmd.com/read/29223586/reduction-in-human-lyme-neuroborreliosis-associated-with-a-major-epidemic-among-roe-deer
#6
Nanna Skaarup Andersen, Sigurdur Skarphédinsson, Fredrikke C Knudtzen, Carsten Riis Olesen, Thøger Gorm Jensen, Per Moestrup Jensen
Lyme neuroborreliosis is the most severe clinical manifestation of Lyme borreliosis. In most of Denmark, and also Europe, the overall prevalence of Lyme borreliosis seems to be stabilising. This is not the case on the island of Funen, Denmark, where the number of human Lyme neuroborreliosis cases has markedly declined throughout the last decade. We propose the reason for the decline is a major epidemic among roe deer, killing almost half of their population, resulting in a reduction in the tick population which make it less likely to get a tick bite and therefore to contract Lyme neuroborreliosis...
December 6, 2017: Ticks and Tick-borne Diseases
https://www.readbyqxmd.com/read/29221707/development-of-a-borreliosis-assay-mannan-coated-polyethylene-sinter-bodies-as-a-new-platform-technology
#7
Mohammed Alasel, Nina Dassinger, Doru Vornicescu, Michael Keusgen
Rapid diagnosis of Lyme borreliosis has been carried out on chemically modified porous polyethylene sinter bodies. Photografting of 2-propenol on sinter body's surface was performed as a first step, introducing active hydroxyl groups as a result of polyalcohol formation. The hydroxyl groups were used for further immobilization and could be linked via 3-aminopropyltriethoxysilane (APTES) to polysaccharides like mannan. Prone to coupling, mannan was activated using N, N'-disuccinimidyl carbonate (DSC) to allow smooth reaction with the primary amine groups of the silane layer...
December 5, 2017: Analytical Biochemistry
https://www.readbyqxmd.com/read/29219091/potential-impact-of-climate-change-on-emerging-vector-borne-and-other-infections-in-the-uk
#8
Matthew Baylis
Climate is one of several causes of disease emergence. Although half or more of infectious diseases are affected by climate it appears to be a relatively infrequent cause of human disease emergence. Climate mostly affects diseases caused by pathogens that spend part of their lifecycle outside of the host, exposed to the environment. The most important routes of transmission of climate sensitive diseases are by arthropod (insect and tick) vectors, in water and in food. Given the sensitivity of many diseases to climate, it is very likely that at least some will respond to future climate change...
December 5, 2017: Environmental Health: a Global Access Science Source
https://www.readbyqxmd.com/read/29208342/pediatric-stroke-related-to-lyme-neuroborreliosis-data-from-the-swiss-neuropaediatric-stroke-registry-and-literature-review
#9
O Monteventi, M Steinlin, M Regényi, E Roulet-Perez, P Weber, J Fluss
BACKGROUND: Cerebrovascular complications of Lyme neuroborreliosis (LNB) are poorly documented in the paediatric population. METHODS: We performed a retrospective analysis from prospectively registered cases of acute ischemic stroke (AIS) from the Swiss NeuroPaediatric Stroke Registry (SNPSR) from 2000 to 2015. Only cases with serologically confirmed LNB were included. In addition, a literature review on paediatric stroke cases secondary to Lyme neuroborreliosis in the same time frame was performed...
November 24, 2017: European Journal of Paediatric Neurology: EJPN
https://www.readbyqxmd.com/read/29207940/time-trend-of-clinical-cases-of-lyme-disease-in-two-hospitals-in-belgium-2000-2013
#10
Mathilde De Keukeleire, Sophie O Vanwambeke, Benoît Kabamba, Leila Belkhir, Philippe Pierre, Victor Luyasu, Annie Robert
BACKGROUND: As several studies indicated an increase in Lyme disease (LD), notably in neighbouring countries, concerns have arisen regarding the evolution of Lyme disease in Belgium. In order to confirm or infirm the increase of LD in Belgium, we focused on hospital admissions of patients diagnosed with LD between 2000 and 2013 based on hospital admission databases from two hospitals in Belgium. METHODS: Hospital databases are a stable recording system. We did a retrospective analysis of the medical files of patients hospitalized with Lyme disease in two Belgian hospitals between 2000 and 2013...
December 5, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/29206879/climate-change-influences-on-the-potential-geographic-distribution-of-the-disease-vector-tick-ixodes-ricinus
#11
Abdelghafar A Alkishe, A Townsend Peterson, Abdallah M Samy
BACKGROUND: Ixodes ricinus is a species of hard tick that transmits several important diseases in Europe and North Africa, including Lyme borreliosis and tick-borne encephalitis. Climate change is affecting the geographic distributions and abundances of arthropod vectors, which in turn influence the geographic distribution and epidemiology of associated vector-borne diseases. To date, few studies have investigated effects of climate change on the spatial distribution of I. ricinus at continental extents...
2017: PloS One
https://www.readbyqxmd.com/read/29205927/areolar-lymphocytoma-in-a-child-a-rare-cutaneous-presentation-of-borreliosis
#12
Chikara Ogimi, Claudia Crowell, Markus D Boos
Lyme disease is a common tick-borne infection caused by Borrelia burgdorferi in the United States, where infection is most prevalent in the northeastern and mid-Atlantic states. Although classically associated with erythema migrans, Lyme disease caused by Borrelia species found in Europe may also present with other cutaneous findings. Here we report the case of a girl who was clinically diagnosed with Lyme disease based on her history of recent travel and the appearance of an areolar lymphocytoma; this was confirmed by testing...
December 4, 2017: Pediatric Dermatology
https://www.readbyqxmd.com/read/29202704/prevention-of-tick-bites-an-evaluation-of-a-smartphone-app
#13
L Antonise-Kamp, D J M A Beaujean, R Crutzen, J E van Steenbergen, D Ruwaard
BACKGROUND: Lyme borreliosis (LB) is the most common reported tick-borne infection in Europe, and involves transmission of Borrelia by ticks. As long as a vaccine is not available and effective measures for controlling tick populations are insufficient, LB control is focused on preventive measures to avoid tick bites. To inform citizens about the risk of ticks, motivate them to check for tick bites, and encourage them to remove any attached tick as quickly as possible, a mobile app called 'Tekenbeet' (Dutch for 'tick bite') was developed and released...
December 4, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/29196626/identification-of-borrelia-protein-candidates-in-mouse-skin-for-potential-diagnosis-of-disseminated-lyme-borreliosis
#14
Antoine Grillon, Benoît Westermann, Paola Cantero, Benoît Jaulhac, Maarten J Voordouw, Delphine Kapps, Elody Collin, Cathy Barthel, Laurence Ehret-Sabatier, Nathalie Boulanger
In vector-borne diseases, the skin plays an essential role in the transmission of vector-borne pathogens between the vertebrate host and blood-feeding arthropods and in pathogen persistence. Borrelia burgdorferi sensu lato is a tick-borne bacterium that causes Lyme borreliosis (LB) in humans. This pathogen may establish a long-lasting infection in its natural vertebrate host where it can persist in the skin and some other organs. Using a mouse model, we demonstrate that Borrelia targets the skin regardless of the route of inoculation, and can persist there at low densities that are difficult to detect via qPCR, but that were infective for blood-feeding ticks...
December 1, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29195857/evaluating-acarological-risk-for-exposure-to-ixodes-scapularis-and-ixodes-scapularis-borne-pathogens-in-recreational-and-residential-settings-in-washington-county-minnesota
#15
Micah B Hahn, Jenna K H Bjork, David F Neitzel, Frances M Dorr, Tessa Whitemarsh, Karen A Boegler, Christine B Graham, Tammi L Johnson, Sarah E Maes, Rebecca J Eisen
The distribution of I. scapularis, the tick vector of the bacteria that cause Lyme disease, has been expanding over the last two decades in the north-central United States in parallel with increasing incidence of human cases of Lyme disease in that region. However, assessments of residential risk for exposure to ticks are lacking from this region. Here, we measured the density of host-seeking I. scapularis nymphs in two suburban and two rural public recreational sites located in Washington County, Minnesota as well as in nearby residential properties...
November 22, 2017: Ticks and Tick-borne Diseases
https://www.readbyqxmd.com/read/29190743/crystal-structure-of-a-tripartite-complex-between-c3dg-c-terminal-domains-of-factor-h-and-ospe-of-borrelia-burgdorferi
#16
Robert Kolodziejczyk, Kornelia M Mikula, Tommi Kotila, Vincent L G Postis, T Sakari Jokiranta, Adrian Goldman, Taru Meri
Complement is an important part of innate immunity. The alternative pathway of complement is activated when the main opsonin, C3b coats non-protected surfaces leading to opsonisation, phagocytosis and cell lysis. The alternative pathway is tightly controlled to prevent autoactivation towards host cells. The main regulator of the alternative pathway is factor H (FH), a soluble glycoprotein that terminates complement activation in multiple ways. FH recognizes host cell surfaces via domains 19-20 (FH19-20). All microbes including Borrelia burgdorferi, the causative agent of Lyme borreliosis, must evade complement activation to allow the infectious agent to survive in its host...
2017: PloS One
https://www.readbyqxmd.com/read/29190281/internet-based-biosurveillance-methods-for-vector-borne-diseases-are-they-novel-public-health-tools-or-just-novelties
#17
REVIEW
Simon Pollett, Benjamin M Althouse, Brett Forshey, George W Rutherford, Richard G Jarman
Internet-based surveillance methods for vector-borne diseases (VBDs) using "big data" sources such as Google, Twitter, and internet newswire scraping have recently been developed, yet reviews on such "digital disease detection" methods have focused on respiratory pathogens, particularly in high-income regions. Here, we present a narrative review of the literature that has examined the performance of internet-based biosurveillance for diseases caused by vector-borne viruses, parasites, and other pathogens, including Zika, dengue, other arthropod-borne viruses, malaria, leishmaniasis, and Lyme disease across a range of settings, including low- and middle-income countries...
November 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29189951/ticks-and-bacterial-tick-borne-pathogens-in-piemonte-region-northwest-italy
#18
Dario Pistone, Massimo Pajoro, Eva Novakova, Nadia Vicari, Cesare Gaiardelli, Roberto Viganò, Camilla Luzzago, Matteo Montagna, Paolo Lanfranchi
A molecular screening for tick-borne pathogens was carried out in engorged and in questing ticks collected in Verbano Cusio Ossola county, Piemonte region, Italy. Engorged ticks were removed from wild and domestic animal hosts. The most abundant and common tick species in the area was Ixodes ricinus (192 adults, 907 nymphs). Few individuals of Ixodes hexagonus (15) and Rhipicephalus sanguineus (7) were found among the ticks removed from domestic animals (46 examined ticks). The presence of Rickettsia spp., Borrelia burgdorferi sensu latu, Francisella tularensis and Coxiella burnetii was evaluated by PCR and sequencing in 392 individuals of I...
November 30, 2017: Experimental & Applied Acarology
https://www.readbyqxmd.com/read/29187292/borrelia-miyamotoi-should-this-pathogen-be-considered-for-the-diagnosis-of-tick-borne-infectious-diseases-in-spain
#19
Ana M Palomar, Aránzazu Portillo, Paula Santibáñez, Sonia Santibáñez, José A Oteo
INTRODUCTION: Borrelia miyamotoi is a tick-borne pathogen belonging to the relapsing fever group. It had not been reported from Spain, but its wide distribution and the presence of the tick-vector (Ixodes ricinus) made us suspect its circulation. The aim of this study was to investigate the presence of Borrelia spp. in I. ricinus in Spain. METHODS: A total of 652 I. ricinus nymphs collected in northern Spain were processed. The DNA was extracted using incubations with ammonium hydroxide...
November 26, 2017: Enfermedades Infecciosas y Microbiología Clínica
https://www.readbyqxmd.com/read/29186026/antimicrobial-activity-of-bee-venom-and-melittin-against-borrelia-burgdorferi
#20
Kayla M Socarras, Priyanka A S Theophilus, Jason P Torres, Khusali Gupta, Eva Sapi
Lyme disease is a tick-borne, multi-systemic disease, caused by the bacterium Borrelia burgdorferi. Though antibiotics are used as a primary treatment, relapse often occurs after the discontinuation of antimicrobial agents. The reason for relapse remains unknown, however previous studies suggest the possible presence of antibiotic resistant Borrelia round bodies, persisters and attached biofilm forms. Thus, there is an urgent need to find antimicrobial agents suitable to eliminate all known forms of B. burgdorferi...
November 29, 2017: Antibiotics
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