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Mahalakshmi Shankaran, Todd W Shearer, Stephen A Stimpson, Scott M Turner, Chelsea King, Po-Yin Anne Wong, Ying Shen, Philip S Turnbull, Fritz Kramer, Lisa Clifton, Alan Russell, Marc K Hellerstein, William J Evans
Biomarkers of muscle protein synthesis rate could provide early data demonstrating anabolic efficacy for treating muscle-wasting conditions. Androgenic therapies have been shown to increase muscle mass primarily by increasing the rate of muscle protein synthesis. We hypothesized that the synthesis rate of large numbers of individual muscle proteins could serve as early response biomarkers and potentially treatment-specific signaling for predicting the effect of anabolic treatments on muscle mass. Utilizing selective androgen receptor modulator (SARM) treatment in the ovariectomized (OVX) rat, we applied an unbiased, dynamic proteomics approach to measure the fractional synthesis rates (FSR) of 167-201 individual skeletal muscle proteins in triceps, EDL, and soleus...
March 15, 2016: American Journal of Physiology. Endocrinology and Metabolism
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