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Zhi-Kun Qiu, Jia-Li He, Xu Liu, Jia Zeng, Ji-Sheng Chen, Hong Nie
ETHNOPHARMACOLOGY RELEVANCE: Post-traumatic stress disorder (PTSD) is a severe psychiatric disorder that is characterized by symptoms of re-experiencing, avoidance and hyperarousal, as well as social and professional dysfunction at least one month after the exposure to a traumatic event. Biosynthesis of allopregnanolone has been suggested as one of the important contributors to PTSD. Albiflorin (AF) extracted from Radix paeoniae Alba had been shown to be effective in the therapy of depression...
December 16, 2016: Journal of Ethnopharmacology
Y Zhu, L Wang, J Wang, Z Yang, C Wang, D Zhao, J Zhang
No abstract text is available yet for this article.
December 2016: Planta Medica
Lingyan Tao, Qing Zhang, Yongjiang Wu, Xuesong Liu
In this study, a fast and effective high-performance liquid chromatography method was developed to obtain a fingerprint chromatogram and quantitative analysis simultaneously of four indexes including gallic acid, chlorogenic acid, albiflorin and paeoniflorin of the traditional Chinese medicine Moluodan Concentrated Pill. The method was performed by using a Waters X-bridge C18 reversed phase column on an Agilent 1200S high-performance liquid chromatography system coupled with diode array detection. The mobile phase of the high-performance liquid chromatography method was composed of 20 mmol/L phosphate solution and acetonitrile with a 1 mL/min eluent velocity, under a detection temperature of 30°C and a UV detection wavelength of 254 nm...
December 2016: Journal of Separation Science
Zeng-Liang Jin, Nana Gao, Weizhe Xu, Pingxiang Xu, Shuaiqi Li, Yuan-Yuan Zheng, Ming Xue
Albiflorin, a traditional Chinese herb, is a main component of Radix paeoniae Alba, which has been used for the treatment of depressive disorders since ancient times. However, the mechanism of the antidepressant effect of albiflorin is poorly understood. Thus, we explored the binding profile of albiflorin at neurotransmitter receptors and transporters. We also characterised the in vivo effect of albiflorin on monoaminergic systems by using microanalysis to determine the extracellular levels of serotonin (5-HT) and norepinephrine (NE) in the hypothalamus of freely moving rats administered albiflorin...
2016: Scientific Reports
Bang-Jiang Fang, Jun-Yi Shen, Hua Zhang, Shuang Zhou, Chuan-Zhu Lyu, Yi-Qiang Xie
OBJECTIVE: To study the mechanism of insulin resistance in the cholesterol gallstone formation from insulin signal transduction pathway so as to reveal the possible mechanism and the effective role of Albiflorin Granule on preventing the cholesterol gallstones. METHODS: Serum triglycerides (TG), free fatty acid (FFA), and total cholesterol (TC) from different groups were measured and liver cells InsR, PKB, IKK-β protein expression levels were detected by western blotting...
September 2016: Asian Pacific Journal of Tropical Medicine
Ying-Li Zhu, Lin-Yuan Wang, Jing-Xia Wang, Chun Wang, Cheng-Long Wang, Dan-Ping Zhao, Zi-Chen Wang, Jian-Jun Zhang
Paeonia lactiflora root (baishao in Chinese) is a commonly used herb in traditional Chinese medicines (TCM). Two isomers, paeoniflorin (PF) and albiflorin (AF), are isolated from P. lactiflora. The present study aimed to investigate the protective effects of PF and AF on myelosuppression induced by chemotherapy in mice and to explore the underlying mechanisms. The mouse myelosuppression model was established by intraperitoneal (i.p.) injection of cyclophosphamide (CP, 200 mg·kg(-1)). The blood cell counts were performed...
August 2016: Chinese Journal of Natural Medicines
Hui Zhang, Xuemin Zhu, Jingjing Shen, Haiheng Xu, Min Ma, Wei Gu, Qiudong Jiang, Jun Chen, Jinao Duan
A prerequisite for successful transdermal or dermal drug therapy is the drug ability to penetration through the skin, especially stratum corneum (SC). The most acceptable technique for measuring skin permeation in vitro is the application of both the Franz diffusion cell device and the skin model. As the skin model, a liposome-based artificial skin membrane (LASM) consisting of tight layers of liposomes immobilized on a filter was prepared and characterized. Using porcine ear skin, rat skin and Strat-M(TM) artificial membrane as control, the LASM was then evaluated in permeation studies with five active compounds, i...
August 31, 2016: Journal of Liposome Research
Yan-Hong Shi, Shu Zhu, Yue-Wei Ge, Kazufumi Toume, Zhengtao Wang, Javzan Batkhuu, Katsuko Komatsu
Monoterpenoids with "cage-like" pinane skeleton are the unique and main bioactive constituents in peony root, the root of Paeonia lactiflora. A liquid chromatography coupled with ion trap and time-of-flight mass spectrometry (LC-IT-TOF-MS) method was developed for characterization and quantification of monoterpenoids in different types of peony root and the roots of related Paeonia species. MS/MS fragmentation patterns of monoterpenoids with paeoniflorin-, albiflorin- and sulfonated paeoniflorin-type of skeletons were elucidated, which provided basic clues enabling subsequent identification of 35 monoterpenoids in LC-MS profiles of Paeonia species...
September 10, 2016: Journal of Pharmaceutical and Biomedical Analysis
Jianyu Zhou, Linyuan Wang, Jingxia Wang, Chun Wang, Zhihui Yang, Chenglong Wang, Yingli Zhu, Jianjun Zhang
Neuropathic pain remains as the most frequent cause of suffering and disability around the world. The isomers paeoniflorin (PF) and albiflorin (AF) are major constituents extracted from the roots of Paeonia (P.) lactiflora Pall. Neuroprotective effect of PF has been demonstrated in animal models of neuropathologies. However, only a few studies are related to the biological activities of AF and no report has been published on analgesic properties of AF about neuropathic pain to date. The aim of this study was to compare the effects of AF and PF against CCI-induced neuropathic pain in rat and explore the underlying mechanism...
2016: Evidence-based Complementary and Alternative Medicine: ECAM
Weizhe Xu, Yan Zhao, Yi Qin, Beikang Ge, Wenwen Gong, Yingting Wu, Xiaorong Li, Yuming Zhao, Pingxiang Xu, Ming Xue
There is evidence suggesting that herbal extracts demonstrate greater bioactivities than their isolated constituents at an equivalent dose. This phenomenon could be attributed to the absence of interacting substances present in the extracts. By measuring the pharmacokinetic parameters of paeoniflorin (PF) and albiflorin (AF) after being orally administered to rats in isolated form, in combination with each other and within total peony glucosides (TPG), respectively, the current study aimed to identify positive pharmacokinetic interactions between components of peony radix extracts...
July 1, 2016: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
Yingli Zhu, Linyuan Wang, Zhihui Yang, Jingxia Wang, Wei Li, Jianyu Zhou, Jianjun Zhang
Paeonia lactiflora root (baishao in Chinese) is a commonly used herb in traditional Chinese medicine (TCM). Paeoniflorin (PF) and albiflorin (AF) are two major active constituents of P. lactiflora. In this paper, we aimed to investigate the hematopoietic effects of PF and AF on myelosuppression mice induced by radiotherapy and to explore the underlying mechanism. The finding indicated that PF and AF significantly increased the numbers of white blood cells (WBC) and reversed the atrophy of thymus. Furthermore, PF and AF increased the levels of granulocyte-macrophage colony-stimulating factor (GM-CSF) and interleukin-3 (IL-3) and reduced the levels of tumor necrosis factor-α (TNF-α) in serum and increased the level of colony-stimulating factor (G-CSF) in plasma...
2016: Evidence-based Complementary and Alternative Medicine: ECAM
Yao Gao, Li Gao, Xiao-xia Gao, Yu-zhi Zhou, Xue-mei Qin, Jun-sheng Tian
The present study aims to predict the action targets of antidepressant active ingredients of Xiaoyaosan to understand the "multi-components, multi-targets and multi-pathways" mechanism. Using network pharmacology, the reported antidepressant active ingredients in Xiaoyaosan (saikosaponin A, saikosaponin C, saikosaponin D, ferulic acid, Z-ligustilide, atractylenolide I, atractylenolide II, atractylenolide III, paeoniflorin, albiflorin, liquiritin, glycyrrhizic acid and pachymic acid), were used to predict the targets of main active ingredients of Xiaoyaosan according to reversed pharmacophore matching method...
December 2015: Yao Xue Xue Bao, Acta Pharmaceutica Sinica
Fei Fei, Hailing Yang, Ying Peng, Pei Wang, Shuyao Wang, Yuqing Zhao, Jingqiu Huang, Xiaoyi Yu, Siqi Feng, Runbin Sun, Na Yang, Hongbo Wang, Jiye Aa, Guangji Wang
A sensitive and reliable method using liquid chromatography tandem mass spectrometry (LC-MS/MS) was established for the simultaneous assay of paeoniflorin and albiflorin in bio-samples of rats after liquid-liquid extraction with ethylacetate. For the first time, the developed method was validated and successfully applied to the pharmacokinetics study of paeoniflorin and albiflorin after oral administration of Total Glucosides Of White Paeony Capsule (TGP). Relative to the intravenous injection, the absolute bio-availabilities of paeoniflorin and albiflorin were 2...
June 1, 2016: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
Yizhi Zhang, Dejun Sun, Qingjin Meng, Wanxu Guo, Qiuhui Chen, Ying Zhang
Albiflorin (AF), one of important bioactive constituents of Paeonia lactiflora Radix, possesses neuro-protective effect. The present study aims to investigate the antinociceptive activities of AF and possible mechanisms. AF suppressed acetic acid-caused writhing, lengthened the latency period of mouse in hot plate test, and reduced the licking and biting response time of the injected mouse paw during phase I and phase II, and it suggested that AF exerted the antinociceptive activity mainly through central nervous system...
August 15, 2016: Neuroscience Letters
Ke Pei, Hao Cai, Yu Duan, Feng-Xian Qiao, Si-Cong Tu, Xiao Liu, Xiao-Li Wang, Xiao-Qing Song, Kai-Lei Fan, Bao-Chang Cai
An accurate and reliable method of high-performance liquid chromatographic fingerprint combining with multi-ingredient determination was developed and validated to evaluate the influence of sulfur-fumigated Paeoniae Radix Alba on the quality and chemical constituents of Si Wu Tang. Multivariate data analysis including hierarchical cluster analysis and principal component analysis, which integrated with high-performance liquid chromatographic fingerprint and multi-ingredient determination, was employed to evaluate Si Wu Tang in a more objective and scientific way...
2016: Journal of Analytical Methods in Chemistry
Chen Cheng, Jia-zhen Lin, Li Li, Jun-ling Yang, Wei-wei Jia, Yu-hong Huang, Fei-fei Du, Feng-qing Wang, Mei-juan Li, Yan-fen Li, Fang Xu, Na-ting Zhang, Olajide E Olaleye, Yan Sun, Jian Li, Chang-hai Sun, Gui-ping Zhang, Chuan Li
AIM: Monoterpene glycosides derived from Paeonia lactiflora roots (Chishao) are believed to be pharmacologically important for the antiseptic herbal injection XueBiJing. This study was designed to characterize the pharmacokinetics and disposition of monoterpene glycosides. METHODS: Systemic exposure to Chishao monoterpene glycosides was assessed in human subjects receiving an intravenous infusion and multiple infusions of XueBiJing injection, followed by assessment of the pharmacokinetics of the major circulating compounds...
April 2016: Acta Pharmacologica Sinica
Yu-Lu Wang, Jing-Xia Wang, Xiao-Xu Hu, Li Chen, Zhi-Kun Qiu, Nan Zhao, Zi-Dan Yu, Shu-Zheng Sun, Yuan-Yuan Xu, Yan Guo, Chang Liu, You-Zhi Zhang, Yun-Feng Li, Chang-Xi Yu
ETHNOPHARMACOLOGY RELEVANCE: Albiflorin, a monoterpene glycoside, is a main component of Radix paeoniae Alba, which could be a Chinese herbal medicine used in the treatment of psychiatric disorders. However, the exact role of albiflorin in depression is poorly understood. AIM OF THE STUDY: The current study aimed to evaluate the antidepressant effect of albiflorin in mice and rats, and the possible mechanism was also determined. MATERIALS AND METHODS: The antidepressant-like effects of albiflorin was determined by using animal models of depression including forced swim and tail suspension tests in mice and chronic unpredictable stress (CUS) in rats...
February 17, 2016: Journal of Ethnopharmacology
Yan-Hong Shi, Shu Zhu, Yue-Wei Ge, Yu-Min He, Kohei Kazuma, Zhengtao Wang, Kayo Yoshimatsu, Katsuko Komatsu
The methanolic extract and its subfractions from red peony root, the dried roots of Paeonia lactiflora Pallas showed potent antiallergic effects, as inhibition of immunoglobulin E (IgE)-mediated degranulation in rat basophil leukemia (RBL)-2H3 cells. Bioassay-guided fractionation led to the isolation of 16 monoterpene derivatives, including 3 new compounds, paeoniflorol (1), 4'-hydroxypaeoniflorigenone (2) and 4-epi-albiflorin (3), together with 13 known ones (4-16). The chemical structures of the new compounds were elucidated on the basis of spectroscopic and chemical evidences...
January 2016: Fitoterapia
Ze-yu Cao, Yue Ding, Zhen-zhen Su, Na Li, Liabg Cao, Gang Ding, Zhen-zhong Wang, Wei Xiao
To clarify the active components in Guizhi Fuling capsule in treatment of intrinsic dysmenorrhea, pelvic inflammation and hysteromyoma, main components were gradually knocked out from the capsules, the effects of knockout capsules on uterine contraction, TNF-α secretion, murine splenocytes (SPL) and hysteromyoma cells proliferation were evaluated, respectively. The inhibition of capsules on uterine contraction was weakened by gradient knockout of paeoniflorin, paeonol, and amygdalin. The suppression of capsulte on TNF-α secretion was reduced by gradient knockout of gallic acid, cinnamaldehyde, pentagalloylglucose, and pachyman...
June 2015: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
Xing Chang, Hongmei Jia, Chao Zhou, Hongwu Zhang, Meng Yu, Junshan Yang, Zhongmei Zou
Chaihu-Shu-Gan-San (CSGS) is a classical traditional Chinese medicine formula for the treatment of depression. As one of the single herbs in CSGS, Bai-Shao displayed antidepressant effect. In order to explore the role of Bai-Shao towards the antidepressant effect of CSGS, the metabolic regulation and chemical profiles of CSGS with and without Bai-Shao (QBS) were investigated using metabonomics integrated with chemical fingerprinting. At first, partial least squares regression (PLSR) analysis was applied to characterize the potential biomarkers associated with chronic unpredictable mild stress (CUMS)-induced depression...
December 1, 2015: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
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