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https://www.readbyqxmd.com/read/29126011/multi-parameters-monitoring-during-traditional-chinese-medicine-concentration-process-with-near-infrared-spectroscopy-and-chemometrics
#1
Ronghua Liu, Qiaofeng Sun, Tian Hu, Lian Li, Lei Nie, Jiayue Wang, Wanhui Zhou, Hengchang Zang
As a powerful process analytical technology (PAT) tool, near infrared (NIR) spectroscopy has been widely used in real-time monitoring. In this study, NIR spectroscopy was applied to monitor multi-parameters of traditional Chinese medicine (TCM) Shenzhiling oral liquid during the concentration process to guarantee the quality of products. Five lab scale batches were employed to construct quantitative models to determine five chemical ingredients and physical change (samples density) during concentration process...
October 28, 2017: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/28933095/-investigation-of-effects-of-albiflorin-and-paeoniflorin-on-hippocampal-bdnf-and-no-in-chronic-restraint-stress-rats
#2
Ying-Li Zhu, Lin-Yuan Wang, Cheng-Long Wang, Dan-Ping Zhao, Sha Wang, Wen-Ting Fei, Jian-Jun Zhang
This paper aimed to investigate the antidepressant-like effects and the mechanism of the albiflorin, paeoniflorin on rats with chronic restraint stress model. Fluoxetine and Xiaoyao group served as the positive control, body weight, sucrose preference test and the open field behavioral experiment were measured, the levels of nitric oxide (NO) in hippocampus were detected by Greg colorimetric method. Furthermore, the levels of brain derived neurotrophic factor (BDNF) in hippocampus were detected by ELISA. Finally, the expressions of nNOS mRNA in hippocampus detected by RT-qPCR, the protein levels of nNOS and BDNF in hippocampus were detected by Western blot...
November 2016: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/28929664/-metabolism-of-paeoniflorin-by-rat-intestinal-flora-in-vitro
#3
Zhong-Cheng Ke, Nan Yang, Xue-Feng Hou, Ai-Dong Wang, Liang Feng, Xiao-Bin Jia
In order to clarify the effect of intestinal flora on the absorption and metabolism of paeoniflorin in vivo, the metabolism of paeoniflorin by rat intestinal flora was studied under the in vitro anaerobic condition. Paeoniflorin was incubated with rat anaerobic intestinal flora for 48 h, and UPLC was used to detect the changes of paeoniflorin at different incubation time points under the following chromatographic conditions:WelchromTM C₁₈ chromatographic column (4.6 mm×100 mm, 5 μm), with 0.1% formic acid(A)-acetonitrile(B) as the mobile phase for gradient elution...
October 2016: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/28925146/-rapid-monitoring-five-components-of-ethanol-precipitation-process-of-shenzhiling-oral-solution-using-near-infrared-spectroscopy
#4
Tong-Tong Li, Tian Hu, Lei Nie, Li-Xuan Zang, Ying-Zi Zeng, Heng-Chang Zang
To develop a method for the rapid monitoring of five components during the alcohol precipitation process of Shenzhiling oral solution using near infrared spectroscopy(NIRS).The contents of five components detemined by high performance liquid chromatography(HPLC) were used as the reference values, and the NIRS based partial least square regression(PLSR) models were used to monitor the concentrations of paeoniflorin, albiflorin, liquiritin, cinnamic acid and glycyrrhizic acid during the alcohol precipitation process of Shenzhiling oral solution, which were optimized and verified through comparing of different spectral pre-processing and variables selection methods...
October 2016: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/28857450/screening-separation-and-evaluation-of-xanthine-oxidase-inhibitors-from-paeonia-lactiflora-using-chromatography-combined-with-a-multi-mode-microplate-reader
#5
Jing Wang, Dongfang Shi, Meizhu Zheng, Bing Ma, Jing Cui, Chunming Liu, Chengyu Liu
Natural products have become one of the most important resources for discovering novel xanthine oxidase inhibitors, which are commonly employed in the treatment of hyperuricemia and gout. However, to date, few reports exist regarding the use of monoterpene glycosides as xanthine oxidase inhibitors. Thus, we herein report the use of ultrafiltration coupled with liquid chromatography in the screening of monoterpene glycoside xanthine oxidase inhibitors from the extract of Paeonia lactiflora (P. lactiflora), and both high-performance counter-current chromatography and medium-pressure liquid chromatography were employed to separate the main constituents...
August 30, 2017: Journal of Separation Science
https://www.readbyqxmd.com/read/28845697/development-of-phospholipid-vesicle-based-permeation-assay-models-capable-of-evaluating-percutaneous-penetration-enhancing-effect
#6
Min Ma, Hong-Jie Di, Hui Zhang, Jun-Hong Yao, Jie Dong, Guo-Jun Yan, Hong-Zhi Qiao, Jun Chen
OBJECTIVES: The phospholipid vesicle-based permeation assay (PVPA) model has recently been introduced as an in vitro model which can mimic stratum corneum (SC) barriers to estimate the skin permeability of drugs. The aim of this study was to evaluate whether the PVPA model was suitable for the evaluation of penetration enhancing effect of skin penetration enhancers (PE). METHODS: The PVPA model was optimized by changing the lipid composition of both small liposomes (SL), and large liposomes (LL)...
December 2017: Drug Development and Industrial Pharmacy
https://www.readbyqxmd.com/read/28808600/simultaneous-determination-of-11-compounds-in-gualou-guizhi-granule-and-pharmacokinetics-study-by-uplc-ms-ms
#7
Chengtao Sun, Wen Xu, Yuqin Zhang, Lishuang Yu, Miao Ye, Kedan Chu, Wei Xu, Yu Lin
A rapid and sensitive ultrafast performance liquid chromatography-tandem mass spectrometry method (UPLC-MS/MS) was developed for the simultaneous determination of 11 compounds in Gualou Guizhi Granule (GLGZG), including liquiritin, isoliquiritin, liquirtin apioside, isoliquiritin apioside, liquiritigenin, isoliquiritigenin, glycyrrhizic acid, glycyrrhetinic acid, paeoniflorin, albiflorin, and paeoniflorin sulfonate in rat plasma. UPLC-MS/MS assay with negative ion mode was performed on a Waters CORTECS C18 (2...
2017: Journal of Analytical Methods in Chemistry
https://www.readbyqxmd.com/read/28783562/simultaneous-determination-of-paeonilactone-a-and-paeonilactone-b-in-rat-plasma-after-oral-administration-of-albiflorin-by-uplc-tof-ms-following-picolinoyl-derivatization
#8
Zhigang Wang, Shuhan Tang, Masao Hattori, Hailong Zhang, Xiuhong Wu
A new highly sensitive analytical method was developed to investigate the in vivo metabolism of albiflorin, one of the most principal components in traditional Chinese medicine. After hydrolyzation with sulfatase, the main metabolites paeonilactone A and paeonilactone B of paeoniflorin in rat plasma were successfully detected for the first time by liquid chromatography mass spectrometry following picolinoyl derivatization. Borneol was used as the internal standard compound to quantify paeonilactone A and paeonilactone B in rat plasma...
September 1, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/28732574/albiflorin-ameliorates-obesity-by-inducing-thermogenic-genes-via-ampk-and-pi3k-akt-in-vivo-and-in-vitro
#9
Mi-Young Jeong, Jinbong Park, Dong-Hyun Youn, Yunu Jung, JongWook Kang, Seona Lim, Min-Woo Kang, Hye-Lin Kim, Hong-Seob So, Raekil Park, Seung-Heon Hong, Jae-Young Um
OBJECTIVE: Brown adipose tissue (BAT) activation has been identified as a possible target to treat obesity and to protect against metabolic diseases by increasing energy consumption. We explored whether albiflorin (AF), a natural compound, could contribute to lowering the high risk of obesity with BAT and primary brown preadipocytes in vivo and in vitro. MATERIALS/METHODS: Human adipose tissue-derived mesenchymal stem cells (hAMSCs) were cultured with adipogenic differentiation media with or without AF...
August 2017: Metabolism: Clinical and Experimental
https://www.readbyqxmd.com/read/28628837/the-influence-of-essential-oils-from-xiang-fu-si-wu-decoction-on-its-non-volatile-components-and-its-application-for-pharmacokinetics-in-normal-rats
#10
Ying Pan, Dawei Qian, Pei Liu, Yang Zhang, Zhenhua Zhu, Li Zhang, Jin-Ao Duan
Xiang-Fu-Si-Wu Decoction (XFSWD) has been used to treat gynecology diseases in clinical practice for hundreds of years in China, especially for primary dysmenorrheal of QiZhi Type. In previous researches, both essential oils (XEO) and non-volatile components (NXEO) extracted from XFSWD showed significant pharmacological activities, but the influence of XEO on NXEO was unclear. The purpose of this paper was to develop a validated analytical method for simultaneous determination of ten components including Vanillic acid, Ferulic acid, Caffeic acid, Gallic acid, Paeoniflorin, Albiflorin, Tetrahydropalmatine, Protopine, Berberine and Tetrahydrocolumbamine, and to compare the pharmacokinetic parameters of these components to illustrate the influences of XEO on NXEO in normal rats...
August 15, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/28557007/simultaneous-determination-of-ginsenoside-rb1-ginsenoside-rg1-paeoniflorin-albiflorin-and-oxypaeoniflorin-in-rat-plasma-by-liquid-chromatography-tandem-mass-spectrometry-application-to-a-pharmacokinetic-study-of-wen-yang-huo-xue-soft-capsule
#11
Xiujun Wu, Yang You, Gonglin Qu, Ran Ma, Mingxue Zhang
A simple and sensitive HPLC-MS/MS method was developed and fully validated for simultaneous determination of ginsenoside Rb1, ginsenoside Rg1, paeoniflorin, albiflorin and oxypaeoniflorin in rat plasma. Plasma samples were pretreated with protein precipitation using acetonitrile. The chromatographic separation was carried out on a C18 column with a gradient mobile phase consisting of acetonitrile and water (containing 0.1% formic acid). All analytes and digoxin (internal stand, IS) were quantitated through electrospray ionization in negative ion multiple reaction monitoring mode...
May 30, 2017: Biomedical Chromatography: BMC
https://www.readbyqxmd.com/read/28468284/anti-inflammatory-effects-sar-and-action-mechanism-of-monoterpenoids-from-radix-paeoniae-alba-on-lps-stimulated-raw-264-7-cells
#12
Xiaoxu Bi, Li Han, Tiange Qu, Yu Mu, Peipei Guan, Xiaodan Qu, Zhanyou Wang, Xueshi Huang
Nine monoterpenoids from Radix Paeoniae Alba, including paeoniflorin derivatives, paeoniflorin (PF), 4-O-methylpaeoniflorin (MPF), 4-O-methylbenzoylpaeoniflorin (MBPF); paeonidanin derivatives, paeonidanin (PD), paeonidanin A (PDA), albiflorin derivatives, albiflorin (AF), benzoylalbiflorin (BAF), galloylalbiflorin (GAF), and debenzoylalbiflorin (DAF), were obtained in our previous phytochemistry investigations. Their anti-inflammatory effects were determined in the present study. The expression and production of pro-inflammatory cytokines in lipopolysaccharides (LPS)-stimulated RAW 264...
April 29, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28437688/application-of-near-infrared-spectroscopy-for-the-rapid-quality-assessment-of-radix-paeoniae-rubra
#13
Hao Zhan, Jing Fang, Liying Tang, Hongjun Yang, Hua Li, Zhuju Wang, Bin Yang, Hongwei Wu, Meihong Fu
Near-infrared (NIR) spectroscopy with multivariate analysis was used to quantify gallic acid, catechin, albiflorin, and paeoniflorin in Radix Paeoniae Rubra, and the feasibility to classify the samples originating from different areas was investigated. A new high-performance liquid chromatography method was developed and validated to analyze gallic acid, catechin, albiflorin, and paeoniflorin in Radix Paeoniae Rubra as the reference. Partial least squares (PLS), principal component regression (PCR), and stepwise multivariate linear regression (SMLR) were performed to calibrate the regression model...
April 20, 2017: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/28428751/identification-of-nf-%C3%AE%C2%BAb-as-determinant-of-posttraumatic-stress-disorder-and-its-inhibition-by-the-chinese-herbal-remedy-free-and-easy-wanderer
#14
Chunlan Hong, Anja Schüffler, Ulrich Kauhl, Jingming Cao, Ching-Fen Wu, Till Opatz, Eckhard Thines, Thomas Efferth
Posttraumatic stress disorder (PTSD) is a mental disorder developing after exposure to traumatic events. Although psychotherapy reveals some therapeutic effectiveness, clinically sustainable cure is still uncertain. Some Chinese herbal formulae are reported to work well clinically against mental diseases in Asian countries, but the safety and their mode of action are still unclear. In this study, we investigated the mechanisms of Chinese remedy free and easy wanderer (FAEW) on PTSD. We used a reverse pharmacology approach combining clinical data to search for mechanisms of PTSD with subsequent in vitro verification and bioinformatics techniques as follows: (1) by analyzing microarray-based transcriptome-wide mRNA expression profiling of PTSD patients; (2) by investigating the effect of FAEW and the antidepressant control drug fluoxetine on the transcription factor NF-κB using reporter cell assays and western blotting; (3) by performing molecular docking and literature data mining based on phytochemical constituents of FAEW...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/28299338/antithrombotic-effect-and-mechanism-of-radix-paeoniae-rubra
#15
Pingyao Xie, Lili Cui, Yuan Shan, Wen-Yi Kang
The compounds of Radix Paeoniae Rubra (RPR) were isolated and identified by bioassay-guided method, and antithrombotic effects and mechanism were investigated by the acute blood stasis rat model. The RPR extract was evaluated by APTT, TT, PT, and FIB assays in vitro. Results indicated that RPR extract exhibited the anticoagulant activity. In order to find active compounds, six compounds were isolated and identified, and four compounds, paeoniflorin (Pae), pentagalloylglucose (Pen), albiflorin (Ali), and protocatechuic acid (Pro), exhibited the anticoagulant activity in vitro...
2017: BioMed Research International
https://www.readbyqxmd.com/read/27993636/anti-ptsd-like-effects-of-albiflorin-extracted-from-radix-paeoniae-alba
#16
Zhi-Kun Qiu, Jia-Li He, Xu Liu, Jia Zeng, Ji-Sheng Chen, Hong Nie
ETHNOPHARMACOLOGY RELEVANCE: Post-traumatic stress disorder (PTSD) is a severe psychiatric disorder that is characterized by symptoms of re-experiencing, avoidance and hyperarousal, as well as social and professional dysfunction at least one month after the exposure to a traumatic event. Biosynthesis of allopregnanolone has been suggested as one of the important contributors to PTSD. Albiflorin (AF) extracted from Radix paeoniae Alba had been shown to be effective in the therapy of depression...
February 23, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/27975815/evaluation-of-5-ht1a-and-5-ht2a-receptors-in-a-rat-model-of-chronic-restraint-stress-antidepressant-like-effects-of-albiflorin
#17
Y Zhu, L Wang, J Wang, Z Yang, C Wang, D Zhao, J Zhang
No abstract text is available yet for this article.
December 2016: Planta Medica
https://www.readbyqxmd.com/read/27758089/quality-evaluation-of-moluodan-concentrated-pill-using-high-performance-liquid-chromatography-fingerprinting-coupled-with-chemometrics
#18
Lingyan Tao, Qing Zhang, Yongjiang Wu, Xuesong Liu
In this study, a fast and effective high-performance liquid chromatography method was developed to obtain a fingerprint chromatogram and quantitative analysis simultaneously of four indexes including gallic acid, chlorogenic acid, albiflorin and paeoniflorin of the traditional Chinese medicine Moluodan Concentrated Pill. The method was performed by using a Waters X-bridge C18 reversed phase column on an Agilent 1200S high-performance liquid chromatography system coupled with diode array detection. The mobile phase of the high-performance liquid chromatography method was composed of 20 mmol/L phosphate solution and acetonitrile with a 1 mL/min eluent velocity, under a detection temperature of 30°C and a UV detection wavelength of 254 nm...
December 2016: Journal of Separation Science
https://www.readbyqxmd.com/read/27646789/receptor-and-transporter-binding-and-activity-profiles-of-albiflorin-extracted-from-radix-paeoniae-alba
#19
Zeng-Liang Jin, Nana Gao, Weizhe Xu, Pingxiang Xu, Shuaiqi Li, Yuan-Yuan Zheng, Ming Xue
Albiflorin, a traditional Chinese herb, is a main component of Radix paeoniae Alba, which has been used for the treatment of depressive disorders since ancient times. However, the mechanism of the antidepressant effect of albiflorin is poorly understood. Thus, we explored the binding profile of albiflorin at neurotransmitter receptors and transporters. We also characterised the in vivo effect of albiflorin on monoaminergic systems by using microanalysis to determine the extracellular levels of serotonin (5-HT) and norepinephrine (NE) in the hypothalamus of freely moving rats administered albiflorin...
2016: Scientific Reports
https://www.readbyqxmd.com/read/27633302/albiflorin-granule-significantly-decreased-the-cholesterol-gallstone-formation-by-the-regulation-of-insulin-transduction-signal
#20
Bang-Jiang Fang, Jun-Yi Shen, Hua Zhang, Shuang Zhou, Chuan-Zhu Lyu, Yi-Qiang Xie
OBJECTIVE: To study the mechanism of insulin resistance in the cholesterol gallstone formation from insulin signal transduction pathway so as to reveal the possible mechanism and the effective role of Albiflorin Granule on preventing the cholesterol gallstones. METHODS: Serum triglycerides (TG), free fatty acid (FFA), and total cholesterol (TC) from different groups were measured and liver cells InsR, PKB, IKK-β protein expression levels were detected by western blotting...
September 2016: Asian Pacific Journal of Tropical Medicine
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