Pavel H Lugo-Fabres, Leslie M Otero-Sastre, Johanna Bernáldez-Sarabia, Tanya A Camacho-Villegas, Noemi Sánchez-Campos, Janeth Serrano-Bello, Luis A Medina, Saé Muñiz-Hernández, Lizbeth de la Cruz, Isabel Arenas, Antonio Barajas-Martínez, David E Garcia, Linda Nuñez-Garcia, Jorge González-Canudas, Alexei F Licea-Navarro
The FDA's approval of peptide drugs such as Ziconotide or Exendin for pain relief and diabetes treatment, respectively, enhanced the interest to explore novel conotoxins from Conus species venom. In general, conotoxins can be used in pathologies where voltage-gated channels, membrane receptors, or ligands alter normal physiological functions, as in metabolic diseases such as Type 2 diabetes. In this study, the synthetic cal14.2b (s-cal14.2b) from the unusual Californiconus californicus demonstrated bioactivity on NIT-1 insulinoma cell lines stimulating insulin secretion detecting by high performance liquid chromatography (HPLC)...
August 1, 2021: Biomedicines