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https://www.readbyqxmd.com/read/28735062/silibinin-ameliorates-anxiety-depression-like-behaviors-in-amyloid-%C3%AE-treated-rats-by-upregulating-bdnf-trkb-pathway-and-attenuating-autophagy-in-hippocampus
#1
Xiaoyu Song, Bo Liu, Lingyu Cui, Biao Zhou, Weiwei Liu, Fanxing Xu, Toshihiko Hayashi, Shunji Hattori, Yuko Ushiki-Kaku, Shin-Ichi Tashiro, Takashi Ikejima
Depression is one of the most frequent psychiatric disorders of Alzheimer's disease (AD). Depression and anxiety are associated with increased risk of developing AD. Silibinin, a flavonoid derived from milk thistle (Silybum marianum), has been used as a hepato-protectant in the clinical treatment of liver diseases. In this study, the effect of silibinin on Aβ-induced anxiety/depression-like behaviors in rats was investigated. Silibinin significantly attenuated anxiety/depression-like behaviors caused by Aβ1-42-treatment as shown in tail suspension test (TST), elevated plus maze (EPM) and forced swimming tests (FST)...
July 19, 2017: Physiology & Behavior
https://www.readbyqxmd.com/read/28735039/frequency-and-correlates-of-sleep-disturbance-in-methadone-and-buprenorphine-maintained-patients
#2
Kelly E Dunn, Patrick H Finan, D Andrew Tompkins, Eric C Strain
BACKGROUND: Opioid use disorder (OUD) is a significant public health problem, and opioid maintenance treatment (OMT) on methadone or buprenorphine is a common approach. This study characterized sleep impairment in patients maintained on methadone or buprenorphine, and evaluated its association with psychiatric and medical comorbidities. METHODS: Participants (N=185) maintained on methadone (N=125) or buprenorphine (N=60) for OUD completed the Medical Outcomes Study Sleep Scale (MOS) to provide a point-prevalence assessment of sleep impairment...
July 14, 2017: Addictive Behaviors
https://www.readbyqxmd.com/read/28734555/decisional-and-dispositional-capacity-determinations-neuropsychiatric-illness-and-an-integrated-clinical-paradigm
#3
REVIEW
James A Bourgeois, Mary Ann Cohen, Jennifer M Erickson, Rebecca Weintraub Brendel
BACKGROUND: Assessment of decisional capacity requires thorough clinical review of a patient's current psychiatric symptoms and cognitive processes. The assessment to determine the patient's capacity for self-management postdischarge is a different clinical concept from decisional capacity. OBJECTIVES: Standardized guidelines for capacity determinations (both for informed consent and for disposition) would be helpful to clinicians, patients, and their caregivers...
May 13, 2017: Psychosomatics
https://www.readbyqxmd.com/read/28734239/stigma-resistance-and-its-association-with-internalised-stigma-and-psychosocial-outcomes-among-psychiatric-outpatients
#4
Ying Wen Lau, Louisa Picco, Shirlene Pang, Anitha Jeyagurunathan, Pratika Satghare, Siow Ann Chong, Mythily Subramaniam
Studies have suggested that stigma resistance plays an important role in the recovery from mental illness. However, there has been limited research in Asian countries that has examined the benefits of stigma resistance among the mentally ill in Asian populations. Hence, this study aimed to assess the prevalence of stigma resistance and establish the socio-demographic correlates of stigma resistance, as well as its association with internalised stigma and psychosocial outcomes among a multi-ethnic population of 280 outpatients with obsessive compulsive disorder (OCD), schizophrenia, depressive disorders and anxiety disorders in Singapore...
July 14, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28734238/decreased-levels-of-g-protein-coupled-estrogen-receptor-in-children-with-autism-spectrum-disorders
#5
Hatice Altun, Ergül Belge Kurutaş, Nilfer Şahin, Hayati Sınır, Ebru Fındıklı
Sex hormones, specially estrogen, and ıt is receptors plays a critical role in the pathogenesis of psychiatric disorders including autism spectrum disorders (ASD). The aim of this study was to investigate the relationship between ASD and G protein-coupled estrogen receptor (GPER), a recently discovered estrogen receptors, and also to study the relation of serum GPER levels with the severity of autistic symptoms. The present study included 45 children with drug naive ASD diagnosed by DSM-V criteria, aged between 3 and 12 years and 40 age- and gender-matched healthy controls...
June 6, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28734198/length-of-stay-for-25-791-california-patients-found-incompetent-to-stand-trial
#6
Matthew Renner, Carol Newark, Bradley J Bartos, Richard McCleary, Nicholas Scurich
Referrals and admissions to state psychiatric hospitals of criminal defendants found Incompetent to Stand Trial (IST) are on the rise in the state of California and other parts of the country. Studies of treatment outcomes of this population have primarily focused on factors that determine competency and/or restorability. However, as IST patients place an increasing resource burden on state psychiatric hospital systems, other outcomes such as length of stay (LOS) are becoming increasingly important for practitioners and policy makers to understand...
July 6, 2017: Journal of Forensic and Legal Medicine
https://www.readbyqxmd.com/read/28734121/the-impact-of-chronic-psychiatric-disorders-on-cognitive-decline
#7
R Villeneuve, C Blanchard, L Rullier, N Raoux, V Bergua, J-F Dartigues, K Pérès, H Amieva
OBJECTIVES: Based on seemingly contradictory results in the existing literature, the objective of our study was to investigate whether older individuals suffering from chronic psychiatric disorders show a more rapid decline in cognitive performances than their non-psychiatric counterparts, or if the pattern of decline through older age is similar in both groups. METHOD: A total of 820 older adults were selected from the Ageing Multidisciplinary Investigation (AMI) cohort study, which studies health-related issues of people over 65 years old living in rural areas...
July 22, 2017: Acta Psychiatrica Scandinavica
https://www.readbyqxmd.com/read/28734096/association-of-toxoplasma-gondii-infection-with-schizophrenia-and-its-relationship-with-suicide-attempts-in-these-patients
#8
Maryam Ansari-Lari, Hassan Farashbandi, Fahimeh Mohammadi
OBJECTIVES: To investigate the association of schizophrenia and T. gondii, and to assess the association of infection with suicide attempts and age of onset of schizophrenia in these patients. METHODS: Case-control study Fars Province, southern Iran. Cases were individuals with psychiatric diagnosis of schizophrenia as per Diagnostic and Statistical Manual of Mental Disorders (DSM-IV) criteria. Controls were healthy blood donors, frequency matched with patients according to age and sex...
July 22, 2017: Tropical Medicine & International Health: TM & IH
https://www.readbyqxmd.com/read/28734057/major-life-events-and-risk-of-alcohol-use-disorders-a-prospective-cohort-study
#9
Emilie Just-Østergaard, Erik L Mortensen, Trine Flensborg-Madsen
AIMS: To estimate associations of individual major life events as well as accumulated major life events in childhood, adult private life and adult work life with risk of alcohol use disorders (AUD). DESIGN: Prospective cohort study with baseline examination in 1991-93 and linkage to national registers to identify AUD at follow-up. SETTING: Copenhagen, Denmark. PARTICIPANTS: Individuals (aged 21 to 93 years) who participated in the Copenhagen City Heart Study in 1991-93 (n=8,758)...
July 22, 2017: Addiction
https://www.readbyqxmd.com/read/28734011/maternal-ssri-discontinuation-use-psychiatric-disorder-and-the-risk-of-autism-in-children-a-meta-analysis-of-cohort-studies
#10
Yusuf Cem Kaplan, Elif Keskin-Arslan, Selin Acar, Kaan Sozmen
We undertook an exclusive meta-analysis of cohort studies investigating the possible link between prenatal SSRI exposure and autism spectrum disorders (ASD) in children to further investigate our previous suggestion of confounding by indication. The point estimates regarding the following cohorts were extracted and pooled: (1) Pregnant women who discontinued SSRI until 3 months before pregnancy. (2) Pregnant women who were exposed to SSRI during pregnancy. (3) Pregnant women with maternal psychiatric disorder but no exposure to SSRI during pregnancy...
July 21, 2017: British Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/28733081/synapsin-antibodies-in-psychiatric-and-neurological-disorders-prevalence-and-clinical-findings
#11
Markus Höltje, Robert Mertens, Morten Brix Schou, Sverre Georg Saether, Elena Kochova, Sven Jarius, Harald Prüss, Lars Komorowski, Christian Probst, Friedemann Paul, Judith Bellmann-Strobl, Daniel Gitler, Fabio Benfenati, Johannes Piepgras, Gudrun Ahnert-Hilger, Klemens Ruprecht
OBJECTIVE: To study the prevalence of autoantibodies to synapsin in patients with psychiatric and neurological disorders and to describe clinical findings in synapsin antibody positive patients. METHODS: Sera of 375 patients with different psychiatric and neurological disorders and sera of 97 healthy controls were screened (dilution 1:320) for anti-synapsin IgG using HEK293 cells transfected with rat synapsin Ia. Positive sera were further analyzed by immunoblots with brain tissue from wild type and synapsin knock out mice and with HEK293 cells transfected with human synapsin Ia and Ib...
July 18, 2017: Brain, Behavior, and Immunity
https://www.readbyqxmd.com/read/28731985/accelerated-dna-methylation-age-associations-with-ptsd-and-mortality
#12
Erika J Wolf, Mark W Logue, Tawni B Stoop, Steven A Schichman, Annjanette Stone, Naomi Sadeh, Jasmeet P Hayes, Mark W Miller
OBJECTIVE: Recently-developed indices of cellular age based on DNA methylation (DNAm) data, referred to as DNAm age, are being used to study factors that influence the rate of aging and the health correlates of these metrics of the epigenetic clock. This study evaluated associations between trauma exposure, posttraumatic stress disorder (PTSD) symptoms, and accelerated versus decelerated DNAm age among military veterans. We also examined if accelerated DNAm age predicted mortality over the course of a 6...
July 20, 2017: Psychosomatic Medicine
https://www.readbyqxmd.com/read/28731778/a-pharmacologic-algorithm-for-youth-who-are-at-high-risk-for-bipolar-disorder
#13
Christopher D Schneck, Kiki D Chang, Manpreet K Singh, Melissa P DelBello, David J Miklowitz
OBJECTIVE: Depression and brief periods of manic symptoms are linked to a significant risk of progression to bipolar disorder (BD) in children who have a first-degree relative with BD I or II. However, little evidence exists to guide the pharmacologic management of children with these high-risk phenotypes. We propose a pharmacological treatment algorithm for high-risk youth and present results on its use in a study of children with a first-degree relative with BD. METHODS: Subjects were 40 youth (mean 12...
July 21, 2017: Journal of Child and Adolescent Psychopharmacology
https://www.readbyqxmd.com/read/28731489/sexual-health-adherence-to-mediterranean-diet-body-weight-physical-activity-and-mental-state-factors-correlated-to-each-other
#14
Pier A Della Camera, Simone Morselli, Gianmartin Cito, Giovanni Tasso, Andrea Cocci, Nicola Laruccia, Fabrizio Travaglini, Dario Del Fabbro, Antonio R Mottola, Mauro Gacci, Sergio Serni, Marco Carini, Alessandro Natali
INTRODUCTION: Mediterranean diet has shown a protective role against cardiovascular disease, diabetes, cancer onset, microvascular damage and dementia in many trials. Our purpose is the assessment of a correlation between physical activity, Mediterranean diet, body mass index (BMI), depression and erection disorder (ED). METHODS: After having signed disclaimer to the study participation, we administered the IIEF 15 questionnaire (International Index of Erectil Function), the Hamilton questionnaire for major depression, the Med-Diet Questionnaire, the Ipaq Questionnaire (International Index of Physical Activity) to 245 patients and calculated the BMI...
July 14, 2017: Urologia
https://www.readbyqxmd.com/read/28731214/from-positive-psychology-to-psychopathology-the-continuum-of-attention-deficit-hyperactivity-disorder
#15
Corina U Greven, Jan K Buitelaar, Giovanni A Salum
BACKGROUND: Integration of positive psychology into clinical research and treatment has been slow. This integration can be facilitated by the conceptualisation of mental disorders as the high, symptomatic extreme of continuous normal variation. This assumes that there is also a low, positive extreme, which is, however, unchartered territory. This study aims to examine how well current measures capture the low extreme of mental disorder continua, using attention-deficit hyperactivity disorder (ADHD) as an example...
July 21, 2017: Journal of Child Psychology and Psychiatry, and Allied Disciplines
https://www.readbyqxmd.com/read/28730847/guidelines-for-the-assessment-and-diagnosis-of-patients-with-schizophrenia-spectrum-and-other-psychotic-disorders
#16
Donald Addington, Sabina Abidi, Iliana Garcia-Ortega, William G Honer, Zahinoor Ismail
OBJECTIVE: The objective of this article is to identify best practices in the diagnosis and assessment of patients with schizophrenia spectrum and other psychotic disorders. The diagnosis and assessment may occur in a range of situations from the emergency room to the outpatient clinic and at different stages of the disorder. The focus may be on acute exacerbations of illness, residual symptoms, levels of function, or changes in the response to treatment. METHODS: A systematic search was conducted for guidelines published in the last 5 years for schizophrenia and schizophrenia spectrum disorders...
January 1, 2017: Canadian Journal of Psychiatry. Revue Canadienne de Psychiatrie
https://www.readbyqxmd.com/read/28730398/prevalence-and-correlates-of-psychological-distress-and-psychiatric-disorders-in-asylum-seekers-and-refugees-resettled-in-an-italian-catchment-area
#17
Michela Nosè, Giulia Turrini, Maria Imoli, Francesca Ballette, Giovanni Ostuzzi, Francesca Cucchi, Chiara Padoan, Mirella Ruggeri, Corrado Barbui
In recent years there has been a progressive rise in the number of asylum seekers and refugees displaced from their country of origin, with significant social, economic, humanitarian and public health implications. The aim of this study is to describe the frequency and correlates of psychological distress and psychiatric disorders in asylum seekers and refugees resettled in an Italian catchment area. In the catchment area of Verona, all male asylum seekers and refugees aged 18 or above included in the Italian protection system for asylum seekers and refugees during a period of 1 year were screened for psychological distress and psychiatric disorders using validated questionnaires...
July 20, 2017: Journal of Immigrant and Minority Health
https://www.readbyqxmd.com/read/28730183/aberrant-cerebellar-connectivity-in-bipolar-disorder-with-psychosis
#18
Ann K Shinn, Youkyung S Roh, Caitlin T Ravichandran, Justin T Baker, Dost Öngür, Bruce M Cohen
BACKGROUND: The cerebellum, which modulates affect and cognition in addition to motor functions, may contribute substantially to the pathophysiology of mood and psychotic disorders, such as bipolar disorder. A growing literature points to cerebellar abnormalities in bipolar disorder. However, no studies have investigated the topographic representations of resting state cerebellar networks in bipolar disorder, specifically their functional connectivity to cerebral cortical networks. METHODS: Using a well-defined cerebral cortical parcellation scheme as functional connectivity seeds, we compared ten cerebellar resting state networks in 49 patients with bipolar disorder and a lifetime history of psychotic features and 55 healthy control participants matched for age, sex, and image signal-to-noise ratio...
July 2017: Biological Psychiatry: Cognitive Neuroscience and Neuroimaging
https://www.readbyqxmd.com/read/28729842/a-gene-based-analysis-of-acoustic-startle-latency
#19
Alicia K Smith, Tanja Jovanovic, Varun Kilaru, Adriana Lori, Lauren Gensler, Samuel S Lee, Seth Davin Norrholm, Nicholas Massa, Bruce Cuthbert, Bekh Bradley, Kerry J Ressler, Erica Duncan
Latency of the acoustic startle response is the time required from the presentation of startling auditory stimulus until the startle response is elicited and provides an index of neural processing speed. Latency is prolonged in subjects with schizophrenia compared to controls in some but not all studies and is 68-90% heritable in baseline startle trials. In order to determine the genetic association with latency as a potential inroad into genetically based vulnerability to psychosis, we conducted a gene-based study of latency followed by an independent replication study of significant gene findings with a single-nucleotide polymorphism (SNP)-based analysis of schizophrenia and control subjects...
2017: Frontiers in Psychiatry
https://www.readbyqxmd.com/read/28729345/recent-advances-in-understanding-and-managing-body-dysmorphic-disorder
#20
REVIEW
Georgina Krebs, Lorena Fernández de la Cruz, David Mataix-Cols
Body dysmorphic disorder (BDD) is a relatively common and disabling psychiatric disorder characterised by excessive and persistent preoccupation with perceived defects or flaws in one's appearance, which are unnoticeable to others, and associated repetitive behaviours (eg, mirror checking). The disorder generally starts in adolescence, but often goes unnoticed and is severely underdiagnosed. Left untreated, BDD typically persists and causes marked functional impairment in multiple domains. This clinical review considers recent advances in the epidemiology and classification of BDD, including its reclassification in the fifth edition of the Diagnostic and Statistical Manual of Mental Disorders under the new 'Obsessive-Compulsive and Related Disorders' chapter...
July 20, 2017: Evidence-based Mental Health
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