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Osteosarcoma adult

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https://www.readbyqxmd.com/read/28051259/microrna-145-inhibits-tumour-growth-and-metastasis-in-osteosarcoma-by-targeting-cyclin-dependent-kinase-cdk6
#1
Y Li, J Liu, Z-Z Liu, W-B Wei
OBJECTIVE: Osteosarcoma (OS) is reported to be one of the most familiar forms of the primary malignant tumor to adolescents and adults, which is usually found in their long bones. Evidence and data have shown that abnormality in micro-RNA expression is closely related to tumorigenesis. The aim of this study is to investigate the expression, function and underlying mechanism of miR-145 in OS. MATERIALS AND METHODS: MiR-145 expression in tumor tissues of patients and cell lines were detected by SYBR green qPCR...
December 2016: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28030831/tumor-targeting-salmonella-typhimurium-a1-r-regresses-an-osteosarcoma-in-a-patient-derived-xenograft-model-resistant-to-a-molecular-targeting-drug
#2
Takashi Murakami, Kentaro Igarashi, Kei Kawaguchi, Tasuku Kiyuna, Yong Zhang, Ming Zhao, Yukihiko Hiroshima, Scott D Nelson, Sarah M Dry, Yunfeng Li, Jane Yanagawa, Tara Russell, Noah Federman, Arun Singh, Irmina Elliott, Ryusei Matsuyama, Takashi Chishima, Kuniya Tanaka, Itaru Endo, Fritz C Eilber, Robert M Hoffman
Osteosarcoma occurs mostly in children and young adults, who are treated with multiple agents in combination with limb-salvage surgery. However, the overall 5-year survival rate for patients with recurrent or metastatic osteosarcoma is 20-30% which has not improved significantly over 30 years. Refractory patients would benefit from precise individualized therapy. We report here that a patient-derived osteosarcoma growing in a subcutaneous nude-mouse model was regressed by tumor-targeting Salmonella typhimurium A1-R (S...
December 20, 2016: Oncotarget
https://www.readbyqxmd.com/read/27990273/advances-in-the-management-of-osteosarcoma
#3
REVIEW
Stefan S Bielack, Stefanie Hecker-Nolting, Claudia Blattmann, Leo Kager
Osteosarcoma, a bone cancer most commonly seen in adolescents and young adults, is usually a high-grade malignancy characterized by a very high risk for the development of pulmonary metastases. High-grade osteosarcomas are usually treated by preoperative and postoperative chemotherapy and surgery, with a very limited number of active agents available. Rarer lower-grade variants such as parosteal and periosteal osteosarcoma or low-grade central osteosarcoma are treated by surgery only. Imaging to search for possible metastases focuses on the lung...
2016: F1000Research
https://www.readbyqxmd.com/read/27986268/-incidence-and-risk-factors-for-ifosfamide-related-encephalopathy-in-sarcoma-patients
#4
Natacha Stern, Ilyes Sakji, Anne-Sophie Defachelles, Cyril Lervat, Thomas Ryckewaert, Guillaume Marliot, Charlotte Peugniez, Dominique Deplanque, Nicolas Penel
CONTEXT: Ifosfamide remains one of the major cytotoxic drugs for sarcoma management. Ifosfamid-related encephalopathy (IRE) is a rare but severe adverse event, without clearly identified risk factors. METHOD: We have carried out a single-center, retrospective study to assess the occurrence and the risk factors for IRE after the two first cycles of chemotherapy. We have collected the data-describing patients, biological data, tumors characteristics (histology, leptomeningeal metastasis) and ifosfamide administration modalities...
December 13, 2016: Bulletin du Cancer
https://www.readbyqxmd.com/read/27933253/primary-intracerebral-osteosarcoma-a-rare-case-report-and-review
#5
Song-Ping Chen, Jin-Long Tang, Xiu-Liang Zhu
BACKGROUND: Primary intracranial osteosarcoma is a extremely rare disease entity. We describe a case of primary intracerebral osteosarcoma in an adult brain. CASE DESCRIPTION: A patient who presented with a 1-week history of headaches, and MRI examination was performed. The immunohistochemical diagnosis confirmed primary intracerebral osteosarcoma. The patient was treated with a surgical resection of the tumor. CONCLUSION: Primary osteosarcomas occurring in the brain are extremely rare...
2016: SpringerPlus
https://www.readbyqxmd.com/read/27904684/ldhb-may-be-a-significant-predictor-of-poor-prognosis-in-osteosarcoma
#6
Chao Li, Yu Chen, Pingping Bai, Jiaqiang Wang, Zhenhui Liu, Tao Wang, Qiqing Cai
Osteosarcoma is the most common primary malignant bone tumor in children and young adults. Lactate dehydrogenase (LDH) is considered as the key glycolytic enzyme and involved in tumor initiation and metabolism. Here, we firstly found that LDHB was highly expressed in osteosarcoma cell lines. Expression profiling indicated that LDHB mRNA was elevated in osteosarcoma tissues with metastasis versus without metastasis, and LDHB high expression predicted a poor prognosis in patients. After LDHB knockdown by siRNA transfection, cell growth and proliferation were inhibited and presented a dose-dependent cell death via MTT assay...
2016: American Journal of Translational Research
https://www.readbyqxmd.com/read/27888627/identification-of-differentially-expressed-genes-in-the-development-of-osteosarcoma-using-rna-seq
#7
Yihao Yang, Ya Zhang, Xin Qu, Junfeng Xia, Dongqi Li, Xiaojuan Li, Yu Wang, Zewei He, Su Li, Yonghong Zhou, Lin Xie, Zuozhang Yang
OBJECTIVE: Osteosarcoma (OS) is a malignant bone tumor with high morbidity in young adults and adolescents. This study aimed to discover potential early diagnosis biomarkers in OS. RESULTS: In total, 111 differentially expressed genes (DEGs) were identified in primary OS compared with normal controls and 235 DEGs were identified in metastatic OS compared with primary OS. AURKB and PPP2R2B were the significantly up-regulated and down-regulated hub proteins, respectively, in the PPI protein-protein network (PPI) network of primary OS...
November 24, 2016: Oncotarget
https://www.readbyqxmd.com/read/27885099/rotationplasty-in-adult-cancer-patients-what-is-the-rehab-strategy-and-what-results-can-be-expected-a-case-study
#8
Mattia Morri, Cristiana Forni
BACKGROUND AND AIM: Rotationplasty is an important and demanding challenge for physiotherapists. The aim of this paper is to describe the functional outcome achieved by a patient undergoing rotationplasty in adult age following osteosarcoma. CASE DESCRIPTION AND METHODS: The patient was followed throughout the rehabilitation course and the results achieved were recorded at 6, 9 and 12 months after surgery. FINDINGS AND OUTCOMES: The results progressively improved in terms of function, functional performance and quality of life...
November 24, 2016: Prosthetics and Orthotics International
https://www.readbyqxmd.com/read/27852052/micrornas-for-osteosarcoma-in-the-mouse-a-meta-analysis
#9
REVIEW
Junli Chang, Min Yao, Yimian Li, Dongfeng Zhao, Shaopu Hu, Xuejun Cui, Gang Liu, Qi Shi, Yongjun Wang, Yanping Yang
Osteosarcoma (OS) is the most common primary malignant bone carcinoma with high morbidity that happens mainly in children and young adults. As the key components of gene-regulatory networks, microRNAs (miRNAs) control many critical pathophysiological processes, including initiation and progression of cancers. The objective of this study is to summarize and evaluate the potential of miRNAs as targets for prevention and treatment of OS in mouse models, and to explore the methodological quality of current studies...
November 12, 2016: Oncotarget
https://www.readbyqxmd.com/read/27845066/cinobufagin-induces-apoptosis-of-osteosarcoma-cells-through-inactivation-of-notch-signaling
#10
Yongfei Cao, Ling Yu, Guo Dai, Shanshan Zhang, Zhengpei Zhang, Tian Gao, Weichun Guo
Osteosarcoma (OS) is a major cause of cancer-related mortality in children and young adults worldwide. Due to preexisting or acquired chemoresistance, the current standard neoadjuvant chemotherapy regimens show only moderate activity against OS. In the current study, we explored the potential anti-OS Cinobufagin in vitro and in vivo, and investigated its underlying mechanisms. The antitumor potential of Cinobufagin was assessed using cell viability assays, and cycle and apoptosis were determined. In a cell-based assay, the mRNA and protein expression of Notch-1, Hes-1, Hes-5 and Hey-1 were determined by quantitative polymerase chain reactions and western blotting...
January 5, 2017: European Journal of Pharmacology
https://www.readbyqxmd.com/read/27820947/effect-of-temporal-changes-in-therapeutic-exposure-on-self-reported-health-status-in-childhood-cancer-survivors
#11
Kirsten K Ness, Melissa M Hudson, Kendra E Jones, Wendy Leisenring, Yutaka Yasui, Yan Chen, Marilyn Stovall, Todd M Gibson, Daniel M Green, Joseph P Neglia, Tara O Henderson, Jacqueline Casillas, Jennifer S Ford, Karen E Effinger, Kevin R Krull, Gregory T Armstrong, Leslie L Robison, Kevin C Oeffinger, Paul C Nathan
Background: The effect of temporal changes in cancer therapy on health status among childhood cancer survivors has not been evaluated. Objective: To compare proportions of self-reported adverse health status outcomes among childhood cancer survivors across 3 decades. Design: Cross-sectional. (ClinicalTrials.gov: NCT01120353). Setting: 27 North American institutions. Participants: 14 566 adults, who survived for 5 or more years after initial diagnosis (median age, 27 years; range, 18 to 48 years), treated from 1970 to 1999...
November 8, 2016: Annals of Internal Medicine
https://www.readbyqxmd.com/read/27817080/retraction-note-to-tissue-expression-levels-of-mir-29b-and-mir-422a-in-children-adolescents-and-young-adults-age-groups-and-their-association-with-prediction-of-poor-prognosis-in-human-osteosarcoma
#12
Reza Bahador, Afshin Taheriazam, Alireza Mirghasemi, Ali Torkaman, Mohammadreza Shakeri, Emad Yahaghi, Peyman Karimi Goudarzi
No abstract text is available yet for this article.
November 5, 2016: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/27761754/review-of-osteosarcoma-and-current-management
#13
REVIEW
Ryan A Durfee, Maryam Mohammed, Hue H Luu
Osteosarcoma is the most common primary malignancy of bone in children and young adults. This tumor has a very heterogeneous genetic profile and lacks any consistent unifying event that leads to the pathogenesis of osteosarcoma. In this review, some of the important genetic events involved in osteosarcoma will be highlighted. Additionally, the clinical diagnosis of osteosarcoma will be discussed, as well as contemporary chemotherapeutic and surgical management of this tumor. Finally, the review will discuss some of the novel approaches to treating this disease...
December 2016: Rheumatology and Therapy
https://www.readbyqxmd.com/read/27760307/molecular-genetics-of-osteosarcoma
#14
Kirby Rickel, Fang Fang, Jianning Tao
Osteosarcoma is the predominant form of bone cancer, affecting mostly adolescents. Recent progress made in molecular genetic studies of osteosarcoma has changed our view on the cause of the disease and ongoing therapeutic approaches for patients. As we draw closer to gaining more complete catalogs of candidate cancer driver genes in common forms of cancer, the landscape of somatic mutations in osteosarcoma is emerging from its first phase. In this review, we summarize recent whole genome and/or whole exome genomic studies, and then put these findings in the context of genetic hallmarks of somatic mutations and mutational processes in human osteosarcoma...
October 17, 2016: Bone
https://www.readbyqxmd.com/read/27651797/establishment-and-characterization-of-a-human-small-cell-osteosarcoma-cancer-stem-cell-line-a-new-possible-in-vitro-model-for-discovering-small-cell-osteosarcoma-biology
#15
Gaia Palmini, Roberto Zonefrati, Cecilia Romagnoli, Alessandra Aldinucci, Carmelo Mavilia, Gigliola Leoncini, Alessandro Franchi, Rodolfo Capanna, Maria Luisa Brandi
Osteosarcoma (OSA) is the most common primary malignant bone tumor, usually arising in the long bones of children and young adults. There are different subtypes of OSA, among which we find the conventional OS (also called medullary or central osteosarcoma) which has a high grade of malignancy and an incidence of 80%. There are different subtypes of high grade OS like chondroblastic, fibroblastic, osteoblastic, telangiectatic, and the small cell osteosarcoma (SCO). In this study, for the first time, we have isolated, established, and characterized a cell line of cancer stem cells (CSCs) from a human SCO...
2016: Stem Cells International
https://www.readbyqxmd.com/read/27650817/initial-testing-stage-1-of-the-curaxin-cbl0137-by-the-pediatric-preclinical-testing-program
#16
Richard Lock, Hernan Carol, John M Maris, E Anders Kolb, Richard Gorlick, C Patrick Reynolds, Min H Kang, Stephen T Keir, Jianrong Wu, Andrei Purmal, Andrei Gudkov, Dias Kurmashev, Raushan T Kurmasheva, Peter J Houghton, Malcolm A Smith
BACKGROUND: CBL0137 is a novel drug that modulates FAcilitates Chromatin Transcription (FACT), resulting in simultaneous nuclear factor-κB suppression, heat shock factor 1 suppression and p53 activation. CBL0137 has demonstrated antitumor effects in animal models of several adult cancers and neuroblastoma. PROCEDURES: CBL0137 was tested against the Pediatric Preclinical Testing Program (PPTP) in vitro cell line panel at concentrations ranging from 1.0 nM to 10...
September 21, 2016: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/27633385/drugs-in-early-clinical-development-for-the-treatment-of-osteosarcoma
#17
Marie-Françoise Heymann, Hannah K Brown, Dominique Heymann
Osteosarcomas are the main malignant primary bone tumours found in children and young adults. Conventional treatment is based on diagnosis and resection surgery, combined with polychemotherapy. This is a protocol that was established in the 1970s. Unfortunately, this therapeutic approach has reached a plateau of efficacy and the patient survival rate has not improved in the last four decades. New therapeutic approaches are thus required to improve the prognosis for osteosarcoma patients. Areas covered: From the databases available and published scientific literature, the present review gives an overview of the drugs currently in early clinical development for the treatment of osteosarcoma...
November 2016: Expert Opinion on Investigational Drugs
https://www.readbyqxmd.com/read/27605071/progress-and-opportunities-for-immune-therapeutics-in-osteosarcoma
#18
Christina K Lettieri, Nicole Appel, Nicole Labban, Danielle M Lussier, Joseph N Blattman, Pooja Hingorani
Survival outcomes for osteosarcoma have plateaued since the 1980s, and patients with relapsed or refractory disease have a particularly dismal outcome. Treatment options for these patients are limited primarily due to the paucity of effective therapeutics. Immune therapies such as tumor vaccines and traditional antigen-targeted monoclonal antibodies have had limited success in solid tumors. The recent discovery of novel immune checkpoint blockade strategies and their success in adult cancers has revitalized the use of immunotherapy strategies for the treatment of solid tumors...
October 2016: Immunotherapy
https://www.readbyqxmd.com/read/27595362/sarcomas-of-soft-tissue-and-bone
#19
Andrea Ferrari, Uta Dirksen, Stefan Bielack
The definition of soft tissue and bone sarcomas include a large group of several heterogeneous subtypes of mesenchymal origin that may occur at any age. Among the different sarcomas, rhabdomyosarcoma, synovial sarcoma, Ewing sarcoma and osteosarcoma are aggressive high-grade malignancies that often arise in adolescents and young adults. Managing these malignancies in patients in this age bracket poses various clinical problems, also because different therapeutic approaches are sometimes adopted by pediatric and adult oncologists, even though they are dealing with the same condition...
2016: Progress in Tumor Research
https://www.readbyqxmd.com/read/27591503/chemotherapy-does-neoadjuvant-or-adjuvant-therapy-improve-outcomes
#20
REVIEW
Robert J Canter
Since preoperative chemotherapy has been clearly shown to improve outcomes for patients with Ewing sarcoma, rhabdomyosarcoma, and osteosarcoma, practitioners have attempted to extend the use of adjuvant/neoadjuvant chemotherapy to other types of adult soft tissue sarcoma. Given the high risk of distant recurrence and disease-specific death for patients with soft tissue sarcoma tumors larger than 10 cm, these patients should be considered candidates for neoadjuvant chemotherapy as well as investigational therapies...
October 2016: Surgical Oncology Clinics of North America
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