Marinus Fislage, Stefan Winzeck, Rebecca Woodrow, Florian Lammers-Lietz, Emmanuel A Stamatakis, Marta M Correia, Jacobus Preller, Insa Feinkohl, Jeroen Hendrikse, Tobias Pischon, Claudia D Spies, Arjen J C Slooter, Georg Winterer, David K Menon, Norman Zacharias
BACKGROUND: Structural disconnectivity was found to precede dementia. Global white matter abnormalities might also be associated with postoperative delirium (POD). METHODS: We recruited older patients (≥65 years) without dementia that were scheduled for major surgery. Diffusion kurtosis imaging metrics were obtained preoperatively, after 3 and 12 months postoperatively. We calculated fractional anisotropy (FA), mean diffusivity (MD), mean kurtosis (MK), and free water (FW)...
March 7, 2024: Alzheimer's & Dementia: the Journal of the Alzheimer's Association