keyword
https://read.qxmd.com/read/38498073/a-pandemic-of-delirium-an-updated-systematic-review-and-meta-analysis-of-occurrence-of-delirium-in-older-adults-with-covid-19
#1
REVIEW
Maria Beatrice Zazzara, Alice Margherita Ornago, Camilla Cocchi, Elisabetta Serafini, Giuseppe Bellelli, Graziano Onder
PURPOSE: Delirium has been recognized as an atypical presenting feature of COVID-19 in older adults and is independently associated with mortality. We aimed to perform an updated systematic review of the literature and proportional meta-analysis to assess prevalence and incidence of delirium in older adults with COVID-19, addressing differences according to sex, frailty status, and settings. METHODS: We searched databases for English-language articles on prevalence and incidence of delirium in older adults with COVID-19, published between March 2020 and January 2023...
March 18, 2024: European Geriatric Medicine
https://read.qxmd.com/read/38497164/identifying-excessive-chronic-alcohol-use-with-phosphatidylethanol-in-patients-with-suspected-severe-injury-results-from-the-idart-study
#2
JOURNAL ARTICLE
Benedicte M Jørgenrud, Camilla C Bråthen, Jo Steinson Stenehjem, Thomas Kristiansen, Leiv Arne Rosseland, Stig Tore Bogstrand
INTRODUCTION: Acute and chronic alcohol use are well-known risk factors for accidents and injuries, and concurrent psychoactive drug use can increase injury risk further. Phosphatidylethanol (PEth) 16:0/18:1 is a biomarker used to determine alcohol consumption the previous 3-4 weeks. The aim was to investigate the prevalence of chronic alcohol use in trauma patients, as determined by PEth 16:0/18:1 concentrations, and how excessive chronic alcohol use relate to demographic variables, injury mechanisms and drug use...
March 16, 2024: Alcohol and Alcoholism
https://read.qxmd.com/read/38495281/can-rifaximin-for-hepatic-encephalopathy-be-discontinued-during-broad-spectrum-antibiotic-treatment
#3
EDITORIAL
Chien-Hao Huang, Piero Amodio
Hepatic encephalopathy (HE) is a formidable complication in patients with decompensated cirrhosis, often necessitating the administration of rifaximin (RFX) for effective management. RFX, is a gut-restricted, poorly-absorbable oral rifamycin derived antibiotic that can be used in addition to lactulose for the secondary prophylaxis of HE. It has shown notable reductions in infection, hospital readmission, duration of hospital stay, and mortality. However, limited data exist about the concurrent use of RFX with broad-spectrum antibiotics, because the patients are typically excluded from studies assessing RFX efficacy in HE...
February 27, 2024: World Journal of Hepatology
https://read.qxmd.com/read/38489126/a-survey-of-non-consultant-hospital-doctors-perspectives-knowledge-and-practices-toward-delirium-in-a-large-irish-hospital
#4
JOURNAL ARTICLE
Mohamed Hassabo, Patrick Mc Cluskey, Joseph Browne, Ontefetse Ntlholang
BACKGROUND: Delirium is a common condition in hospitals, particularly among older people. This refers to a dramatic decline in mental capabilities, which is marked by diminished concentration and consciousness. AIM: The purpose of this study was to assess the views, knowledge, and behavior of non-consultant hospital doctors in managing delirium in a large Irish hospital. METHODS: Questionnaires were administered to 28 healthcare professionals from various departments according to Davis and MacLullich (Age Ageing 38(5):559-563, 2009)...
March 15, 2024: Irish Journal of Medical Science
https://read.qxmd.com/read/38488983/predictive-performance-of-different-measures-of-frailty-cfs-mfi-11-mfi-5-on-postoperative-adverse-outcomes-among-colorectal-cancer-patients-a-diagnostic-meta-analysis
#5
REVIEW
Lingyu Ding, Qianwen Hua, Jiaojiao Xu, Jing Yang, Cui Yao
PURPOSE: To clarify the predictive performance of different measures of frailty, including Clinical Frailty Scale (CFS), 11-factor modified Frailty Index (mFI-11), and 5-factor modified Frailty Index (mFI-5), on adverse outcomes. METHODS: PubMed, Embase, Web of Science, and other databases were retrieved from the inception of each database to June 2023. The pooled sensitivity, specificity, and the area under the summary receiver operating curve (SROC) values were analyzed to determine the predictive power of CFS, mFI-11, and mFI-5 for adverse outcomes...
March 15, 2024: European Geriatric Medicine
https://read.qxmd.com/read/38488422/antipsychotics-in-the-treatment-of-delirium-in-critically-ill-patients-a-systematic-review-and-meta-analysis-of-randomized-controlled-trials
#6
JOURNAL ARTICLE
Kallirroi Laiya Carayannopoulos, Fayez Alshamsi, Dipayan Chaudhuri, Laura Spatafora, Joshua Piticaru, Kaitryn Campbell, Waleed Alhazzani, Kimberley Lewis
OBJECTIVES: To conduct a systematic review and meta-analysis assessing whether the use of antipsychotic medications in critically ill adult patients with delirium impacts patient-important outcomes. DATA SOURCES: A medical librarian searched Ovid MEDLINE, EMBASE, APA PsycInfo, and Wiley's Cochrane Library as well as clinicaltrials.gov and the World Health Organization International Clinical Trials Registry Platform up to November 2023. STUDY SELECTION: Independently and in duplicate, reviewers screened abstracts and titles for eligibility, then full text of qualifying studies...
March 15, 2024: Critical Care Medicine
https://read.qxmd.com/read/38487837/the-association-between-cerebral-blood-flow-variations-during-on-pump-coronary-artery-bypass-grafting-surgery-and-postoperative-delirium
#7
JOURNAL ARTICLE
Caterina Sampaolesi, Erika Casarotta, Giacomo Gresti, Giulia Mariotti, Leonardo Pisani, Diego Veccia, Marco Di Eusanio, Pietro Giorgio Malvindi, Abele Donati, Christopher Maria Münch
INTRODUCTION: Postoperative delirium (POD) has a major impact on patient recovery after cardiac surgery. Although its pathophysiology remains unclear, there could be a correlation between cerebral blood flow (CBF) variations during cardio-pulmonary bypass (CPB) and POD. Our study aimed to evaluate whether variations in on-pump CBF, compared to pre-anesthesia and pre-CPB values, are associated with POD following coronary artery bypass grafting (CABG) surgery. METHODS: This prospective observational cohort study included 95 adult patients undergoing elective on-pump CABG surgery...
March 15, 2024: Perfusion
https://read.qxmd.com/read/38485466/preoperative-cognitive-impairment-and-postoperative-delirium-among-holocaust-survivors-who-achieved-longevity
#8
JOURNAL ARTICLE
Yotam Weiss, Shiri Zarour, Yossef Kiselevich, Maher Abu Ghanim, Daniel Hikry, Isaac Sinai Brzezinski, Lilach Zac, Barak Cohen, Idit Matot
BACKGROUND: Holocaust survivors (HS) experience higher rates of physiological and psychological morbidities, increasing their vulnerability to perioperative complications. Limited information exists regarding their perioperative neurocognitive disorders. This study aimed to assess the rates of preoperative cognitive impairment, postoperative delirium, and other complications among HS aged 75+ undergoing elective surgery. METHODS: This is a single-center retrospective cohort study that analyzed prospectively collected data...
March 14, 2024: Journal of the American Geriatrics Society
https://read.qxmd.com/read/38482541/the-risk-of-delirium-after-sedation-with-propofol-or-midazolam-in-intensive-care-unit-patients
#9
JOURNAL ARTICLE
Thomas G van Gelder, Irene J van Diem-Zaal, Sandra M A Dijkstra-Kersten, Nikki de Mul, Arief Lalmohamed, Arjen J C Slooter
AIM: Knowledge of risk factors may provide strategies to reduce the high burden of delirium in intensive care unit (ICU) patients. We aimed to compare the risk of delirium after deep sedation with propofol versus midazolam in ICU patients. METHODS: In this prospective cohort study, ICU patients who were in an unarousable state for ≥24 h due to continuous sedation with propofol and/or midazolam were included. Patients admitted ≤24 h, those with an acute neurological disorder and those receiving palliative sedation were excluded...
March 14, 2024: British Journal of Clinical Pharmacology
https://read.qxmd.com/read/38480928/prevalence-risk-factors-and-impact-of-delirium-in-adult-inpatients-in-a-tertiary-care-hospital-a-point-prevalence-study
#10
JOURNAL ARTICLE
Cornel Schiess, Lisa Hofer, Stefanie Von Felten, Jan Bartussek, Heidi Petry, Jutta Ernst
AIMS: To describe the point prevalence, risk factors and possible outcomes of delirium in inpatients. DESIGN: A cross-sectional point prevalence study. BACKGROUND: Delirium is an acute brain syndrome that negatively affects patients, healthcare professionals and institutions alike; it is common in inpatient settings and is preventable in about one third of cases. Although guidelines recommend systematic screening and assessment, delirium is often unrecognised, undiagnosed and uncoded...
March 13, 2024: Journal of Clinical Nursing
https://read.qxmd.com/read/38479735/-hfe-genotypes-haemochromatosis-diagnosis-and-clinical-outcomes-at-age-80-years-a-prospective-cohort-study-in-the-uk-biobank
#11
JOURNAL ARTICLE
Mitchell R Lucas, Janice L Atkins, Luke C Pilling, Jeremy D Shearman, David Melzer
OBJECTIVES: HFE haemochromatosis genetic variants have an uncertain clinical penetrance, especially to older ages and in undiagnosed groups. We estimated p.C282Y and p.H63D variant cumulative incidence of multiple clinical outcomes in a large community cohort. DESIGN: Prospective cohort study. SETTING: 22 assessment centres across England, Scotland, and Wales in the UK Biobank (2006-2010). PARTICIPANTS: 451 270 participants genetically similar to the 1000 Genomes European reference population, with a mean of 13...
March 13, 2024: BMJ Open
https://read.qxmd.com/read/38476062/the-impact-of-ketamine-on-outcomes-in-critically-ill-patients-a-systematic-review-with-meta-analysis-and-trial-sequential-analysis-of-randomized-controlled-trials
#12
JOURNAL ARTICLE
Yerkin Abdildin, Karina Tapinova, Assel Nemerenova, Dmitriy Viderman
BACKGROUND: This meta-analysis aims to evaluate the effects of ketamine in critically ill intensive care unit (ICU) patients. METHODS: We searched for randomized controlled trials (RCTs) in PubMed, Scopus, and the Cochrane Library; the search was performed initially in January but was repeated in December of 2023. We focused on ICU patients of any age. We included studies that compared ketamine with other traditional agents used in the ICU. We synthesized evidence using RevMan v5...
February 2024: Acute and critical care
https://read.qxmd.com/read/38475700/effect-of-clock-rhythm-on-emergence-agitation-and-early-postoperative-delirium-in-older-adults-undergoing-thoracoscopic-lung-cancer-surgery-protocol-for-a-prospective-observational-cohort-study
#13
JOURNAL ARTICLE
Linghui Jiang, Jie Wang, Wannan Chen, Zhiyao Wang, Wanxia Xiong
INTRODUCTION: Surgeries conducted at night can impact patients' prognosis, and the mechanism may be related to circadian rhythm, which influence normal physiological functions and pathophysiological changes. Melatonin is primarily a circadian hormone with hypnotic and chronobiotic effects, thereby affecting disease outcomes through influencing the expression of inflammatory factors and biochemical metabolism. This study aims to observe the effects of circadian rhythms on emergence agitation and early postoperative delirium of older individuals undergoing thoracoscopic lung cancer surgery and explore the possible regulatory role of melatonin...
March 12, 2024: BMC Geriatrics
https://read.qxmd.com/read/38471987/monitoring-of-cerebral-blood-flow-autoregulation-physiologic-basis-measurement-and-clinical-implications
#14
REVIEW
Eric L Vu, Charles H Brown, Kenneth M Brady, Charles W Hogue
Cerebral blood flow (CBF) autoregulation is the physiologic process whereby blood supply to the brain is kept constant over a range of cerebral perfusion pressures ensuring a constant supply of metabolic substrate. Clinical methods for monitoring CBF autoregulation were first developed for neurocritically ill patients and have been extended to surgical patients. These methods are based on measuring the relationship between cerebral perfusion pressure and surrogates of CBF or cerebral blood volume (CBV) at low frequencies (<0...
March 11, 2024: British Journal of Anaesthesia
https://read.qxmd.com/read/38470855/covid-19-and-the-impact-on-delirium-care-of-hospitalized-older-adults-a-qualitative-study
#15
JOURNAL ARTICLE
Tru Byrnes, Kimberly Pate, Latasia Belin, Kelley Jo A Weaver, Allyson Cochran
BACKGROUND: Older adult patients with COVID-19 and delirium experience higher rates of adverse outcomes. Early recognition of at-risk patients and implementation of management strategies improve outcomes, though understanding barriers to acute care nurses implementing these strategies is limited. PURPOSE: This study's purpose was to understand the experiences of acute care nurses providing care to older adults with COVID-19 and delirium. Experiences explored included assessment, nursing management interventions, and barriers to care...
March 11, 2024: Journal of Nursing Care Quality
https://read.qxmd.com/read/38463596/correlation-analysis-between-plasma-biomarkers-albumin-fibrinogen-and-their-ratio-with-postoperative-delirium-in-patients-undergoing-non-cardiac-surgery-a-systematic-review-and-meta-analysis
#16
REVIEW
Zhenhui Lu, Bei Wang, Meinv Liu, Dongdong Yu, Jianli Li
OBJECTIVES: This meta-analysis aimed to investigate the correlation between plasma biomarkers, such as albumin and fibrinogen, and their ratio with postoperative delirium (POD) in patients undergoing non-cardiac surgery. METHODS: Relevant observational cohort studies were systematically searched in PubMed, EMBASE, CINAHL, and the Cochrane Library databases as of March 2023. This meta-analysis was conducted using RevMan 5.4.1 and Stata 15.0 software. For continuous variables with non-uniform units, the standardized mean difference (SMD) and 95% confidence intervals (CIs) were used; otherwise, the mean difference (MD) and 95% CIs were employed...
2024: American Journal of Translational Research
https://read.qxmd.com/read/38463110/point-prevalence-and-clinical-profile-of-patients-with-delirium-admitted-in-internal-medicine-department-at-tertiary-care-centre-in-eastern-nepal-a-descriptive-cross-sectional-study
#17
JOURNAL ARTICLE
Tek Nath Yogi, Sujan Puri, Bhupendra Shah, Suraj Nepal, Akshat Mishra
INTRODUCTION: Delirium, marked by acute disturbances in consciousness and cognition, remains underdiagnosed despite its significant impact on morbidity and mortality. This study investigates the point prevalence and clinical profile of delirium in patients at an eastern Nepal tertiary care centre. METHODS: A 1-month descriptive cross-sectional study involved 152 Internal Medicine Department patients at BPKIHS, Dharan. Data, collected through face-to-face interviews and the Confusion Assessment Method (CAM), analyzed demographic details, clinical history, and laboratory findings...
March 2024: Annals of Medicine and Surgery
https://read.qxmd.com/read/38462415/current-practices-and-attitudes-of-cardiac-nurses-regarding-cognitive-screening-in-patients-with-acute-coronary-syndrome
#18
JOURNAL ARTICLE
Emma Zhao, Nicole Lowres, Jacqueline Bloomfield, Joseph Weddell, Geoffrey Tofler, Robyn Gallagher
BACKGROUND: Cognitive impairment (CI) is common in patients with acute coronary syndrome (ACS) but is often undetected and may affect recovery and secondary prevention uptake. Nurses play a crucial role providing care for patients with ACS and promoting secondary prevention. AIM: This study aimed to explore current nursing practices and barriers regarding CI screening in patients with ACS. METHODS: Cardiac nurses were recruited from three metropolitan teaching hospitals and two professional associations in Australia and undertook a 38-question purpose-built survey...
March 9, 2024: Heart, Lung & Circulation
https://read.qxmd.com/read/38461276/effects-of-short-term-preoperative-intranasal-dexmedetomidine-plus-conventional-treatment-on-delirium-following-cardiac-surgery-in-patients-with-sleep-disorders
#19
JOURNAL ARTICLE
Jun Fang, Jia Yang, Mingyu Zhai, Qiong Zhang, Min Zhang, Yanhu Xie
STUDY OBJECTIVES: To assess whether preoperative dexmedetomidine (DEX) nasal drips combined with conventional treatment could mitigate the occurrence of postoperative delirium (POD). DESIGN: A prospective randomised controlled study. SETTING: The cardiac surgery intensive care unit (CSICU) and patient hospitalisation ward at a university hospital. PARTICIPANTS: A total of 100 patients (aged ≥60 years) undergoing cardiac surgery at a university hospital between 7 January 2022, and 30 November 2022 met the eligibility criteria and were included in the study...
March 9, 2024: Perioperative Medicine
https://read.qxmd.com/read/38460247/an-exploratory-study-on-the-heterogeneity-of-postoperative-delirium-preoperative-cognitive-screening-does-not-detect-hallucinatory-delirium-risk
#20
JOURNAL ARTICLE
Shugo Yajima, Yasukazu Nakanishi, Ryo Andy Ogasawara, Naoki Imasato, Kohei Hirose, Sao Katsumura, Madoka Kataoka, Hitoshi Masuda
INTRODUCTION: This study compared the clinical characteristics of patients who had hallucinations and those who did not during delirium after elective cancer surgery. MATERIALS AND METHODS: This study retrospectively observed 1137 consecutive patients who had preoperative screening by a trained nurse before elective major urologic cancer surgery in our department. We compared the patient characteristics, including mini-cognitive assessment instrument (Mini-Cog) and Geriatric-8 (G8) scores, between those who developed postoperative delirium and those who did not, and also between those who had hallucinations and those who did not during delirium...
March 3, 2024: European Journal of Surgical Oncology
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