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https://www.readbyqxmd.com/read/28646080/considerations-from-the-iq-induction-working-group-in-response-to-drug-drug-interaction-guidances-from-regulatory-agencies-focus-on-down-regulation-cyp2c-induction-and-cyp2b6-positive-control
#1
Niresh Hariparsad, Diane Ramsden, Jairam Palamanda, Joshua G Dekeyser, Odette A Fahmi, Jane R Kenny, Heidi Einolf, Michael Mohutsky, Magalie Pardon, Amy Y Siu, Liangfu Chen, Michael Sinz, Barry Jones, Robert Walsky, Shannon Dallas, Suresh K Balani, George Zhang, David Buckley, Donald Tweedie
The European Medicines Agency (EMA), the Pharmaceutical and Medical Devices Agency and the Food and Drug Administration have issued guidances for the conduct of drug-drug interaction (DDI) studies. To examine the applicability of these regulatory recommendations specifically for induction, a group of scientists, under the auspices of the Drug Metabolism Leadership Group of the Innovation and Quality (IQ) Consortium, formed the Induction Working Group (WG). A team of 20 scientists, from 16 of the 39 pharmaceutical companies, which are members of the IQ Consortium, and three Contract Research Organizations, reviewed the recommendations, focusing initially on the current EMA guidance...
June 23, 2017: Drug Metabolism and Disposition: the Biological Fate of Chemicals
https://www.readbyqxmd.com/read/28641609/a-systematic-review-of-the-psychometric-properties-usability-and-clinical-impacts-of-mobile-mood-monitoring-applications-in-young-people
#2
M Dubad, C Winsper, C Meyer, M Livanou, S Marwaha
BACKGROUND: Mobile mood-monitoring applications are increasingly used by mental health providers, widely advocated within research, and a potentially effective method to engage young people. However, little is known about their efficacy and usability in young populations. METHOD: A systematic review addressing three research questions focused on young people: (1) what are the psychometric properties of mobile mood-monitoring applications; (2) what is their usability; and (3) what are their positive and negative clinical impacts? Findings were synthesised narratively, study quality assessed and compared with evidence from adult studies...
June 23, 2017: Psychological Medicine
https://www.readbyqxmd.com/read/28632201/advantageous-developmental-outcomes-of-advancing-paternal-age
#3
M Janecka, F Rijsdijk, D Rai, A Modabbernia, A Reichenberg
Advanced paternal age (APA) at conception has been associated with negative outcomes in offspring, raising concerns about increasing age at fatherhood. Evidence from evolutionary and psychological research, however, suggests possible link between APA and a phenotypic advantage. We defined such advantage as educational success, which is positively associated with future socioeconomic status. We hypothesised that high IQ, strong focus on the subject of interest and little concern about 'fitting in' will be associated with such success...
June 20, 2017: Translational Psychiatry
https://www.readbyqxmd.com/read/28630376/functional-connectivity-disturbances-of-the-ascending-reticular-activating-system-in-temporal-lobe-epilepsy
#4
Dario J Englot, Pierre-Francois D'Haese, Peter E Konrad, Monica L Jacobs, John C Gore, Bassel W Abou-Khalil, Victoria L Morgan
OBJECTIVE: Seizures in temporal lobe epilepsy (TLE) disturb brain networks and lead to connectivity disturbances. We previously hypothesised that recurrent seizures in TLE may lead to abnormal connections involving subcortical activating structures including the ascending reticular activating system (ARAS), contributing to neocortical dysfunction and neurocognitive impairments. However, no studies of ARAS connectivity have been previously reported in patients with epilepsy. METHODS: We used resting-state functional MRI recordings in 27 patients with TLE (67% right sided) and 27 matched controls to examine functional connectivity (partial correlation) between eight brainstem ARAS structures and 105 cortical/subcortical regions...
June 19, 2017: Journal of Neurology, Neurosurgery, and Psychiatry
https://www.readbyqxmd.com/read/28626445/adverse-childhood-experiences-are-linked-to-age-of-onset-and-reading-recognition-in-multiple-sclerosis
#5
Michael T Shaw, Natalie O Pawlak, Ariana Frontario, Kathleen Sherman, Lauren B Krupp, Leigh E Charvet
BACKGROUND: Adverse childhood experiences (ACEs) exert a psychological and physiological toll that increases risk of chronic conditions, poorer social functioning, and cognitive impairment in adulthood. OBJECTIVE: To investigate the relationship between childhood adversity and clinical disease features in multiple sclerosis (MS). METHODS: Sixty-seven participants with MS completed the ACE assessment and neuropsychological assessments as part of a larger clinical trial of cognitive remediation...
2017: Frontiers in Neurology
https://www.readbyqxmd.com/read/28623837/abnormal-asymmetry-in-benign-epilepsy-with-unilateral-and-bilateral-centrotemporal-spikes-a-combined-fmri-and-dti-study
#6
Weifang Cao, Yaodan Zhang, Changyue Hou, Fei Yang, Jinnan Gong, Sisi Jiang, Yue Huang, Ruhui Xiao, Cheng Luo, Xiaoming Wang, Dezhong Yao
Benign epilepsy with centrotemporal spikes (BECTS) is the most common idiopathic focal childhood epilepsy associated with either unilateral or bilateral epileptic discharge. Asymmetry as an important characteristic of the human brain is beneficial for brain functions. However, little is known about on asymmetry of BECTS patients with different epileptic spikes pattern. In the present study, we investigated functional and structural asymmetries in unilateral spikes BECTS (U_BECTS) patients and bilateral spikes BECTS (B_BECTS) patients using resting state functional magnetic resonance images and diffusion tensor imaging...
June 8, 2017: Epilepsy Research
https://www.readbyqxmd.com/read/28623779/the-honest-truth-about-deception-demographic-cognitive-and-neural-correlates-of-child-repeated-deceptive-behavior
#7
Sandra Thijssen, Andrea Wildeboer, Marinus H van IJzendoorn, Ryan L Muetzel, Sandra J E Langeslag, Vincent W V Jaddoe, Frank C Verhulst, Henning Tiemeier, Marian J Bakermans-Kranenburg, Tonya White
This study examined situational, psychological, and neurobiological factors associated with deceptive behavior in 8-year-old children. By assessing deception in low- and high-risk conditions, we differentiated between children displaying some dishonesty and children who deceived repeatedly, and we assessed the correlates of deception in 163 children. A large majority of the children were deceptive in the low-risk condition (n=121, 74.2%), but most children refrained from deception when at risk for getting caught (69 of 121)...
June 14, 2017: Journal of Experimental Child Psychology
https://www.readbyqxmd.com/read/28619530/neural-networks-underlying-language-and-social-cognition-during-self-other-processing-in-autism-spectrum-disorders
#8
Rajesh K Kana, Emma B Sartin, Carl Stevens, Hrishikesh D Deshpande, Christopher Klein, Mark R Klinger, Laura Grofer Klinger
The social communication impairments defining autism spectrum disorders (ASD) may be built upon core deficits in perspective-taking, language processing, and self-other representation. Self-referential processing entails the ability to incorporate self-awareness, self-judgment, and self-memory in information processing. Very few studies have examined the neural bases of integrating self-other representation and semantic processing in individuals with ASD. The main objective of this functional MRI study is to examine the role of language and social brain networks in self-other processing in young adults with ASD...
June 12, 2017: Neuropsychologia
https://www.readbyqxmd.com/read/28609624/in-silico-absorption-distribution-metabolism-excretion-and-pharmacokinetics-adme-pk-utility-and-best-practices-an-industry-perspective-from-the-international-consortium-for-innovation-through-quality-in-pharmaceutical-development
#9
Franco Lombardo, Prashant V Desai, Rieko Arimoto, Kelly E Desino, Holger Fischer, Christopher E Keefer, Carl Petersson, Susanne Winiwarter, Fabio Broccatelli
In silico tools to investigate absorption, distribution, metabolism, excretion and pharmacokinetics (ADME-PK) properties of new chemical entities are an integral part of the current industrial drug discovery paradigm. While many companies are active in the field, scientists engaged in this area don't necessarily share the same background and have limited resources when seeking guidance on how to initiate and maintain an in silico ADME-PK infrastructure in an industrial setting. This work summarizes the views of a group of industrial in silico and experimental ADME scientists, participating in the In Silico ADME Working Group, a subgroup of the International Consortium for Innovation through Quality in Pharmaceutical Development (IQ) Drug Metabolism Leadership Group...
June 13, 2017: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28605630/cognitive-outcome-after-epilepsy-surgery-in-children-a-controlled-longitudinal-study
#10
Valentina Sibilia, Carmen Barba, Tiziana Metitieri, Giovanni Michelini, Flavio Giordano, Lorenzo Genitori, Renzo Guerrini
OBJECTIVE: To analyze the determinants of cognitive outcome two years after surgery for drug-resistant epilepsy in a cohort of 31 children when compared to a control group of 14 surgical candidates who had yet to undergo surgery two years after the first neuropsychological assessment. METHODS: Controlled longitudinal study including three evaluations of IQ (Intelligence Quotient) scores or GDQ (General Developmental Quotient) for each group depending on the patient's age: prior to surgery (T0), one year (T1) and two years (T2) after surgery for the surgical group; baseline (T0) and one year (T1) and 2years (T2) after the first evaluation for the control-group...
June 9, 2017: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/28604499/academic-achievement-and-risk-factors-for-adolescents-with-attention-deficit-hyperactivity-disorder-in-middle-school-and-early-high-school
#11
Nardia Zendarski, Emma Sciberras, Fiona Mensah, Harriet Hiscock
OBJECTIVE: Examine academic achievement of students with attention-deficit hyperactivity disorder (ADHD) during the early high school period and identify potentially modifiable risk factors for low achievement. METHOD: Data were collected through surveys (adolescent, parent, and teacher) and direct assessment of Australian adolescents (12-15 yr; n = 130) with ADHD in early high school (i.e., US middle and high school grades). Academic achievement outcomes were measured by linking to individual performance on the National Assessment Program-Literacy and Numeracy (NAPLAN) tests, direct assessment of reading and math, and teacher report of academic competence...
June 7, 2017: Journal of Developmental and Behavioral Pediatrics: JDBP
https://www.readbyqxmd.com/read/28600987/does-gender-moderate-the-association-between-intellectual-ability-and-accidental-injuries-evidence-from-the-1953-stockholm-birth-cohort-study
#12
Carl Bonander, Carolina Jernbro
In this paper, we test for gender differences in the effects of intellectual ability on accidental injury risks using longitudinal data from the 1953 Stockholm Birth Cohort study (n=14,294). Intellectual ability was measured using IQ tests issued during a school survey at age ∼13, and outcome and covariate data was collected via record linkage to population and health registers, following the cohort from childhood to 55 years of age. We used ICD codes to identify accidental injuries resulting in hospital admissions and deaths, and shared frailty models to quantify the effects of IQ, while allowing for within-individual dependencies and recurrent events...
June 7, 2017: Accident; Analysis and Prevention
https://www.readbyqxmd.com/read/28595670/healthy-cognitive-ageing-in-the-lothian-birth-cohort-studies-marginal-gains-not-magic-bullet
#13
J Corley, S R Cox, I J Deary
In the face of shifting demographics and an increase in human longevity, it is important to examine carefully what is known about cognitive ageing, and to identify and promote possibly malleable lifestyle and health-related factors that might mitigate age-associated cognitive decline. The Lothian Birth Cohorts of 1921 (LBC1921, n = 550) and 1936 (LBC1936, n = 1091) are longitudinal studies of cognitive and brain ageing based in Scotland. Childhood IQ data are available for these participants, who were recruited in later life and then followed up regularly...
June 9, 2017: Psychological Medicine
https://www.readbyqxmd.com/read/28589840/characterization-of-a-sea-urchin-iq-motif-containing-protein-d-as-a-coactivator-of-nuclear-receptors
#14
Mi Ae Kim, Young Chang Sohn
Nuclear receptor (NR) interacting proteins, such as coactivators and corepressors, play a crucial role in specifying the transcriptional activity of the receptor. However, little is known about the functional features of the NR coregulators in marine invertebrates. Using the yeast two-hybrid screening method, a sea urchin oocyte cDNA library was screened for proteins that interact with the ligand-binding domain of human RXRα (hRXRα) as the bait protein in the presence of 9-cis retinoic acid. Here, we describe IQ motif containing protein D (IQCD) as an RXR-interacting coactivator...
June 2017: Zoological Science
https://www.readbyqxmd.com/read/28582399/effect-of-verbal-task-complexity-in-a-working-memory-paradigm-in-patients-with-type-1-diabetes-a-fmri-study
#15
Joan Guàrdia-Olmos, Geisa B Gallardo-Moreno, Esteve Gudayol-Ferré, Maribel Peró-Cebollero, Andrés A González-Garrido
Type 1 diabetes (T1D) is commonly diagnosed in childhood and adolescence, and the developing brain has to cope with its deleterious effects. Although brain adaptation to the disease may not result in evident cognitive dysfunction, the effects of T1D on neurodevelopment could alter the pattern of BOLD fMRI activation. The aim of this study was to explore the neural BOLD activation pattern in patients with T1D versus that of healthy matched controls while performing two visuospatial working memory tasks, which included a pair of assignments administered through a block design...
2017: PloS One
https://www.readbyqxmd.com/read/28579801/meat-intake-and-the-dose-of-vitamin-b3-nicotinamide-cause-of-the-causes-of-disease-transitions-health-divides-and-health-futures
#16
REVIEW
Lisa J Hill, Adrian C Williams
Meat and vitamin B3 - nicotinamide - intake was high during hunter-gatherer times. Intake then fell and variances increased during and after the Neolithic agricultural revolution. Health, height, and IQ deteriorated. Low dietary doses are buffered by 'welcoming' gut symbionts and tuberculosis that can supply nicotinamide, but this co-evolved homeostatic metagenomic strategy risks dysbioses and impaired resistance to pathogens. Vitamin B3 deficiency may now be common among the poor billions on a low-meat diet...
2017: International Journal of Tryptophan Research: IJTR
https://www.readbyqxmd.com/read/28578665/risk-factors-for-dementia-in-the-ninth-decade-of-life-and-beyond-a-study-of-the-lothian-birth-cohort-1921
#17
Ruth A Sibbett, Tom C Russ, Ian J Deary, John M Starr
BACKGROUND: With increasing numbers of people surviving beyond eighty years, this section of the population demands attention to reduce the impact of dementia. In order to develop effective preventative strategies, it is essential to understand age-specific risk factor profiles for dementia: do risk factors for dementia in those in their sixties and seventies persist into oldest age? The aims of this study were to determine incident dementia and to investigate the risk profile for dementia from age 79 to 95 years in a well-characterised cohort...
June 2, 2017: BMC Psychiatry
https://www.readbyqxmd.com/read/28568910/sex-differences-in-parent-reported-executive-functioning-and-adaptive-behavior-in-children-and-young-adults-with-autism-spectrum-disorder
#18
Emily I White, Gregory L Wallace, Julia Bascom, Anna C Armour, Kelly Register-Brown, Haroon S Popal, Allison B Ratto, Alex Martin, Lauren Kenworthy
This study is the largest to date examining executive function and adaptive skills in females with autism spectrum disorder (ASD). Its primary aim was to utilize parent ratings of real-world executive functioning and adaptive behavior to better understand whether females with ASD differ from males with ASD in these areas of everyday functioning. We compared 79 females with ASD to 158 males with ASD (ages 7-18) who were statistically matched on age, IQ, and level of ADHD or ASD traits. All participants were assessed using the Behavior Rating Inventory of Executive Function (BRIEF) and a subset (56 females and 130 males) also received the Vineland Adaptive Behavior Scales (VABS)...
June 1, 2017: Autism Research: Official Journal of the International Society for Autism Research
https://www.readbyqxmd.com/read/28562263/birth-weight-and-intelligence-in-young-adulthood-and-midlife
#19
Trine Flensborg-Madsen, Erik Lykke Mortensen
OBJECTIVES: We examined the associations between birth weight and intelligence at 3 different adult ages. METHODS: The Copenhagen Perinatal Cohort is comprised of children born in Copenhagen from 1959 to 1961. Information on birth weight and ≥1 tests of intelligence was available for 4696 members of the cohort. Intelligence was assessed at a mean age of 19 years with the Børge Priens Prøve test, at age 28 years with the Wechsler Adult Intelligence Scale, and at age 50 years with the Intelligenz-Struktur-Test 2000 R...
May 10, 2017: Pediatrics
https://www.readbyqxmd.com/read/28558774/gender-based-disparities-in-the-impact-of-adverse-childhood-experiences-on-adult-health-findings-from-a-national-study-in-the-kingdom-of-saudi-arabia
#20
Maha Almuneef, Nathalie ElChoueiry, Hassan N Saleheen, Majid Al-Eissa
BACKGROUND: Adverse Childhood Experiences (ACEs) have been linked to an increased risk of health and social problems throughout life. Studies on gender differences from developing countries are scarce. In this paper, we will examine gender variations in the types of reported ACEs and gender-specific relationships between cumulative ACEs and physical and mental health, and Risky Health Behaviors (RHB) in adulthood in the Kingdom of Saudi Arabia (KSA). METHODS: A cross sectional national study was conducted in all of the 13 regions in KSA in 2013 using the ACE- International Questionnaire (ACE-IQ)...
May 30, 2017: International Journal for Equity in Health
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