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https://www.readbyqxmd.com/read/28910243/fluoride-exposure-and-reported-learning-disability-diagnosis-among-canadian-children-implications-for-community-water-fluoridation
#1
Amanda M Barberio, Carlos Quiñonez, F Shaun Hosein, Lindsay McLaren
OBJECTIVES: Recent studies have connected increased fluoride exposure with increased risk of neurodevelopmental-related outcomes, such as ADHD (attention deficit hyperactivity disorder) and lower IQ in children. Our primary objective was to examine the association between fluoride exposure and reported diagnosis of a learning disability among a population-based sample of Canadian children aged 3-12 years. METHODS: We analyzed data from Cycles 2 and 3 of the Canadian Health Measures Survey...
September 14, 2017: Canadian Journal of Public Health. Revue Canadienne de Santé Publique
https://www.readbyqxmd.com/read/28906578/ultra-early-hematoma-growth-in-antithrombotic-pretreated-patients-with-intracerebral-hemorrhage
#2
Jaume Roquer, Rosa María Vivanco-Hidalgo, Jaume Capellades, Angel Ois, Elisa Cuadrado-Godia, Eva Giralt-Steinhauer, Carolina Soriano-Tárraga, Marina Mola-Caminal, Maria Serra-Martínez, Carla Avellaneda-Gómez, Jordi Jiménez-Conde, Ana Rodríguez-Campello
BACKGROUND: Patients with acute intracerebral hemorrhage (ICH) pretreated with antithrombotic drugs may have increased early hematoma growth, which would increase mortality risk. We analyzed the effect of antiplatelet (AP) and vitamin-K antagonist (VKA) pretreatment on ultra-early hematoma growth (uHG), and its relationship with mortality in patients with acute supratentorial ICH. METHODS: This is an observational retrospective study of a prospective register of 197 ICH patients with first computed tomography (CT) scan taken less than 6 hours from ICH symptoms onset...
September 14, 2017: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
https://www.readbyqxmd.com/read/28906246/the-relationship-between-central-auditory-processing-language-and-cognition-in-children-being-evaluated-for-central-auditory-processing-disorder
#3
Lauren Brenneman, Elizabeth Cash, Gail D Chermak, Linda Guenette, Gay Masters, Frank E Musiek, Mallory Brown, Julianne Ceruti, Krista Fitzegerald, Kristin Geissler, Jennifer Gonzalez, Jeffrey Weihing
BACKGROUND: Pediatric central auditory processing disorder (CAPD) is frequently comorbid with other childhood disorders. However, few studies have examined the relationship between commonly used CAPD, language, and cognition tests within the same sample. PURPOSE: The present study examined the relationship between diagnostic CAPD tests and "gold standard" measures of language and cognitive ability, the Clinical Evaluation of Language Fundamentals (CELF) and the Wechsler Intelligence Scale for Children (WISC)...
September 2017: Journal of the American Academy of Audiology
https://www.readbyqxmd.com/read/28893587/current-nonclinical-testing-paradigm-enables-safe-entry-to-first-in-human-clinical-trials-the-iq-consortium-nonclinical-to-clinical-translational-database
#4
Thomas M Monticello, Thomas W Jones, Donna M Dambach, David M Potter, Michael W Bolt, Maggie Liu, Douglas A Keller, Timothy K Hart, Vivek J Kadambi
The contribution of animal testing in drug development has been widely debated and challenged. An industry-wide nonclinical to clinical translational database was created to determine how safety assessments in animal models translate to First-In-Human clinical risk. The blinded database was composed of 182 molecules and contained animal toxicology data coupled with clinical observations from phase I human studies. Animal and clinical data were categorized by organ system and correlations determined. The 2×2 contingency table (true positive, false positive, true negative, false negative) was used for statistical analysis...
September 8, 2017: Toxicology and Applied Pharmacology
https://www.readbyqxmd.com/read/28883765/software-based-evaluation-of-a-class-solution-for-prostate-imrt-planning
#5
Sarah Clarke, Josie Goodworth, Justin Westhuyzen, Brendan Chick, Matthew Hoffmann, Jacqueline Pacey, Stuart Greenham
AIM: To use plan analysis software to evaluate a class solution for prostate intensity modulated radiotherapy (IMRT) planning. BACKGROUND: Class solutions for radiotherapy planning are increasingly being considered for streamlining planning. Plan analysis software provides an objective approach to evaluating radiotherapy plans. MATERIALS AND METHODS: Three iterations of a class solution for prostate IMRT planning (T1, T2 and Tfinal) were compared to the clinical plan of 74 prostate patients using radiotherapy plan analysis software (Plan IQ™, Sun Nuclear Corporation)...
November 2017: Reports of Practical Oncology and Radiotherapy
https://www.readbyqxmd.com/read/28882722/cognition-in-patients-with-benign-epilepsy-with-centrotemporal-spikes-a-study-with-long-term-veeg-and-rs-fmri
#6
Xinxin Yan, Qing Yu, Yuting Gao, Liting Li, Danhua Yu, Ying Chen, Xiaojuan Yao, Weidong Yang, Zhijuan Chen, Jianzhong Yin, Yang An, Ke Tan
OBJECTIVE: The purpose of this study was to investigate the relationship between alterations of functional brain network and cognition in patients with benign epilepsy with centrotemporal spikes (BECTS) as a function of spike-wave index (SWI) during slow wave sleep. METHODS: Resting-state functional magnetic resonance imaging (RS-fMRI) data and Intelligence Quotient (IQ) were collected from two groups of patients with BECTS, including a SWI<50% group (5 cases) and a SWI≥50% group (7 cases)...
September 4, 2017: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/28878722/prenatal-internal-locus-of-control-is-positively-associated-with-offspring-iq-mediated-through-parenting-behavior-prenatal-lifestyle-and-social-circumstances
#7
Jean Golding, Steven Gregory, Genette L Ellis, Yasmin Iles-Caven, Stephen Nowicki
Locus of control (LOC) is a measure that identifies the likelihood as to whether an individual considers what happens to him is largely a matter of luck or fate (known as externally oriented) or whether it is something that the individual can influence (internality). Here we have used data collected as part of the Avon Longitudinal Study of Parents and Children (ALSPAC) to determine the associations between the mothers' LOC orientation before the birth of the child and her child's cognition measured at age 8...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/28876165/development-of-material-specific-hemispheric-specialization-from-beginning-to-end
#8
Benjamin Gingras, Claude M J Braun
Disparity of verbal and performance intelligence (VIQ, PIQ) on the Wechsler scales of intelligence is a conceptually cluttered and empirically weak measure of hemispheric specialization (HS). However, in the context of life span research, it is the only measure that can be exploited meta-analytically with the lesion method from prenatal life to late senescence. We assembled 1917 cases with a unilateral cortical focal brain lesion occurring at all ages and a post-lesion VIQ and PIQ. Lesion locus, volume and side were documented for each case, as well as age at lesion onset, age at first symptoms and age at the IQ test, presence/absence of epilepsy, lesion aetiology, gender, date of publication or of transfer of medical file...
September 6, 2017: Laterality
https://www.readbyqxmd.com/read/28872902/maturational-trajectory-of-processing-speed-performance-in-pediatric-multiple-sclerosis
#9
Nadine Akbar, Alessio Signori, Maria Pia Amato, Maria Pia Sormani, Emilio Portaccio, Claudia Niccolai, Benedetta Goretti, Christine Till, Brenda Banwell
Processing speed is a frequently affected cognitive domain in pediatric multiple sclerosis (MS) and is commonly assessed using the Symbol Digit Modalities Test (SDMT). The objective of this study was to determine maturational trajectories in SDMT performance and baseline factors affecting trajectories in a sample of 82 pediatric MS individuals. Performance on the SDMT increased with age in patients with pediatric MS followed by a subsequent decline. Furthermore, patients who were older at disease onset and had a higher IQ showed greater gains with age, suggesting that these factors may be protective with respect to cognitive maturation in pediatric MS...
September 5, 2017: Developmental Neuropsychology
https://www.readbyqxmd.com/read/28870865/changes-in-water-manganese-levels-and-longitudinal-assessment-of-intellectual-function-in-children-exposed-through-drinking-water
#10
Laurie-Anne Dion, Dave Saint-Amour, Sébastien Sauvé, Benoit Barbeau, Donna Mergler, Maryse F Bouchard
BACKGROUND: Manganese is commonly found in water but potential neurotoxic effects from exposure through drinking water are poorly understood. We previously reported a cross-sectional study showing that drinking water Mn concentration was associated with lower IQ in children aged 6 to 13 years. OBJECTIVE: For this follow-up study, we aimed to re-assess the relation between exposure to Mn from drinking water and IQ at adolescence. In addition, we aimed to examine whether changes in drinking water Mn concentration was associated with changes in IQ scores...
September 1, 2017: Neurotoxicology
https://www.readbyqxmd.com/read/28868634/effects-of-video-feedback-intervention-on-harmonious-parent-child-interaction-and-sensitive-discipline-of-parents-with-intellectual-disabilities-a-randomized-controlled-trial
#11
M W Hodes, M Meppelder, M de Moor, S Kef, C Schuengel
BACKGROUND: This study tested whether video-feedback intervention based on attachment and coercion theory increased harmonious parent-child interaction and sensitive discipline of parents with mild intellectual disabilities or borderline intellectual functioning. METHODS: Observer ratings of video-recorded structured interaction tasks at home formed pretest, post-test, and 3-month follow-up outcome data in a randomized controlled trial with 85 families. Repeated measures analyses of variance and covariance were conducted to test for the intervention effect and possible moderation by IQ and adaptive functioning...
September 3, 2017: Child: Care, Health and Development
https://www.readbyqxmd.com/read/28865170/a-method-for-characterizing-and-matching-ct-image-quality-across-ct-scanners-from-different-manufacturers
#12
James Winslow, Yakun Zhang, Ehsan Samei
PURPOSE: The purpose of this study was to quantitatively characterize the fundamental aspects of image quality (IQ) associated with different computed tomography (CT) reconstruction algorithms, the resolution, noise texture, noise magnitude per dose, and use those data to devise a methodology to match IQ between different CT systems. METHODS AND MATERIALS: This study entailed a three step methodology involving (1) characterizing the noise magnitude, texture, and resolution for a CT system-reconstruction using the relationship between noise magnitude and Computed Tomography Dose Index (CTDI), noise power spectrum (NPS), and modulation transfer function (MTF), (2) developing clinically relevant strategies of weighting the differences among system-reconstructions as a means to determine the best match (3) identifying for each target system-reconstruction, system-reconstructions with matched in terms of that minimum IQ differences...
September 2, 2017: Medical Physics
https://www.readbyqxmd.com/read/28864712/age-at-intervention-for-permanent-hearing-loss-and-5-year-language-outcomes
#13
Teresa Y C Ching, Harvey Dillon, Laura Button, Mark Seeto, Patricia Van Buynder, Vivienne Marnane, Linda Cupples, Greg Leigh
OBJECTIVES: Universal newborn hearing screening has been implemented to detect permanent childhood hearing loss (PCHL) early, with the ultimate goal of improving outcomes through early treatment. However, there is disagreement between studies on the size of this benefit and in some cases whether it is significantly different from 0. There have been no studies of sufficient size in which researchers have determined reliably whether the effect varies with degree of PCHL. We aimed to explore how intervention timing influences 5-year language in children with PCHL...
September 2017: Pediatrics
https://www.readbyqxmd.com/read/28864000/first-trimester-placental-thickness-and-the-risk-of-preeclampsia-or-sga
#14
Chantale Vachon-Marceau, Suzanne Demers, Stéphanie Markey, Nan Okun, Mario Girard, John Kingdom, Emmanuel Bujold
INTRODUCTION: Placental thickness in the second trimester of pregnancy has been associated with risks of placenta-mediated complications of pregnancy. We aimed to estimate the association between first-trimester maximum placental thickness and the subsequent risk of preeclampsia and/or the delivery of small-for-gestational-age (SGA) neonate. METHODS: Prospective cohort study of women recruited at 11-14 weeks gestation. Placental thickness was measured at its apparent center and reported in multiple of median (MoM) adjusted for gestational age...
September 2017: Placenta
https://www.readbyqxmd.com/read/28858004/accommodative-behavior-of-eyes-wearing-aspheric-single-vision-contact-lenses
#15
Basal H Altoaimi, Meznah S Almutairi, Pete Kollbaum, Arthur Bradley
SIGNIFICANCE: Wearing aspheric contact lenses adds significant amounts of negative spherical aberration (SA). Also, when accommodated and converged to near targets, pupil size shrinks and SA shift from positive to more negative direction. Interestingly, in this study, pupil miosis was fully or partially able to compensate for the additional accommodation-induced negative SA. PURPOSE: The present study aims to examine the accommodative response characteristics of young eyes fit with aspheric single vision contact lenses (SVCLs) that add significant negative SA to the eye responding to a wide range of accommodation stimuli...
August 29, 2017: Optometry and Vision Science: Official Publication of the American Academy of Optometry
https://www.readbyqxmd.com/read/28851290/genetic-basis-of-brain-size-evolution-in-cetaceans-insights-from-adaptive-evolution-of-seven-primary-microcephaly-mcph-genes
#16
Shixia Xu, Xiaohui Sun, Xu Niu, Zepeng Zhang, Ran Tian, Wenhua Ren, Kaiya Zhou, Guang Yang
BACKGROUND: Cetacean brain size expansion is an enigmatic event in mammalian evolution, yet its genetic basis remains poorly explored. Here, all exons of the seven primary microcephaly (MCPH) genes that play key roles in size regulation during brain development were investigated in representative cetacean lineages. RESULTS: Sequences of MCPH2-7 genes were intact in cetaceans but frameshift mutations and stop codons was identified in MCPH1. Extensive positive selection was identified in four of six intact MCPH genes: WDR62, CDK5RAP2, CEP152, and ASPM...
August 29, 2017: BMC Evolutionary Biology
https://www.readbyqxmd.com/read/28839270/a-novel-mechanism-of-erk1-2-regulation-in-smooth-muscle-involving-acetylation-of-the-erk1-2-scaffold-iqgap1
#17
Susanne Vetterkind, Qian Qian Lin, Kathleen G Morgan
Ceramide, a bioactive lipid and signaling molecule associated with cardiovascular disease, is known to activate extracellular signal regulated kinases 1 and 2 (ERK1/2). Here, we determined that the effect of ceramide on ERK1/2 is mediated by ceramide signaling on an ERK scaffold protein, IQ motif containing GTPase activating protein 1 (IQGAP1). Experiments were performed with aortic smooth muscle cells using inhibitor screening, small interfering RNA (siRNA), immunoprecipitation (IP), immunoblots and bioinformatics...
August 24, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28837420/relationship-between-childhood-bullying-and-addictive-and-anti-social-behaviors-among-adults-in-saudi-arabia-a-cross-sectional-national-study
#18
Maha Almuneef, Hassan N Saleheen, Nathalie ElChoueiry, Majid A Al-Eissa
Background Bullying is a widespread public health problem among youth with potentially far reaching negative implications. Objective To determine the prevalence of childhood bullying and its association with addictive and anti-social behaviors among adults. Subjects Adults (n = 10,156) aged ≥18 years were invited to participate. Methods A cross-sectional, national study utilizing Adverse Childhood Experiences International Questionnaire (ACE-IQ) was conducted in Saudi Arabia (SA). Odds ratios (OR) and 95% confidence intervals (CIs) were calculated for bullying in relation to the outcome...
August 24, 2017: International Journal of Adolescent Medicine and Health
https://www.readbyqxmd.com/read/28829775/novel-subgroups-of-attention-deficit-hyperactivity-disorder-identified-by-topological-data-analysis-and-their-functional-network-modular-organizations
#19
Sunghyon Kyeong, Jae-Jin Kim, Eunjoo Kim
Attention-deficit/hyperactivity disorder (ADHD) is a clinically heterogeneous condition and identification of clinically meaningful subgroups would open up a new window for personalized medicine. Thus, we aimed to identify new clinical phenotypes in children and adolescents with ADHD and to investigate whether neuroimaging findings validate the identified phenotypes. Neuroimaging and clinical data from 67 children with ADHD and 62 typically developing controls (TDCs) from the ADHD-200 database were selected...
2017: PloS One
https://www.readbyqxmd.com/read/28822870/maternal-obesity-and-attention-related-symptoms-in-the-preterm-offspring
#20
Jelske W van der Burg, Elizabeth T Jensen, Margot van de Bor, Robert M Joseph, T Michael O'Shea, Karl Kuban, Elizabeth N Allred, Megan Scott, Scott Hunter, Stephen R Hooper, Olaf Dammann, Alan Leviton
BACKGROUND: Maternal pre-pregnancy obesity, in term-born children, is associated with an increased risk of attention problems, however this relationship has not been explored among children born extremely preterm. AIM: To estimate the risk of attention problems at age 10years in children born very preterm to overweight (i.e., body mass index (BMI) 25-29kg/m(2)) and obese (i.e., BMI≥30kg/m(2)) women relative to the risk among children born to women who were neither overweight nor obese (i...
August 17, 2017: Early Human Development
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