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https://www.readbyqxmd.com/read/29456808/administration-of-melatonin-protects-against-acetylsalicylic-acid-induced-impairment-of-male-reproductive-function-in-mice
#1
Niloufar Hedayati Emami, Farzaneh Mahmoudi Lafout, Fahimeh Mohammadghasemi
Objectives: Melatonin, an important hormone secreted by the epiphysis, is a powerful anti-oxidant with a high potential to neutralize medical toxins. The goal of this study was to demonstrate the beneficial effect of melatonin on epididymal sperm and reproductive parameters in mice treated with acetylsalicylic acid (ASA). Materials and Methods: Male adult mice were divided into four treatment groups: control, ASA, melatonin, and ASA+melatonin. Mice were administered ASA (50 mg/kg, orally) and/or melatonin (10 mg/kg, intraperitoneally), or vehicle control, for 14 days...
February 2018: Iranian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/29455953/the-comprehensive-characterization-of-adrenocortical-steroidogenesis-using-two-dimensional-ultra-performance-liquid-chromatography-electrospray-ionization-tandem-mass-spectrometry
#2
Gellért Karvaly, Krisztián Kovács, Katalin Mészáros, Ibolya Kocsis, Attila Patócs, Barna Vásárhelyi
The perturbation of the homeostasis of adrenocortical steroids plays a fundamental role in several pathological conditions. Currently, only a few of the substances involved in steroidogenesis are routinely analysed in clinical laboratories for the diagnosis of these conditions. Recently, interest has grown over the development of clinical assays of endogenous steroids using liquid chromatography-tandem mass spectrometry (LC-MS/MS). However, no approaches have assessed the adrenocortical steroidogenesis comprehensively...
February 3, 2018: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/29454168/genetic-and-environmental-influences-on-pubertal-hormones-in-human-hair-across-development
#3
Andrew D Grotzinger, Daniel A Briley, Laura E Engelhardt, Frank D Mann, Megan W Patterson, Jennifer L Tackett, Elliot M Tucker-Drob, K Paige Harden
Puberty is a complex biopsychosocial process that can affect an array of psychiatric and medical disorders emerging in adolescence. Although the pubertal process is driven by neuroendocrine changes, few quantitative genetic studies have directly measured puberty-relevant hormones. Hair samples can now be assayed for accumulation of hormones over several months. In contrast to more conventional salivary measures, hair measures are not confounded by diurnal variation or hormonal reactivity. In an ethnically and socioeconomically diverse sample of 1286 child and adolescent twins and multiples from 672 unique families, we estimated genetic and environmental influences on hair concentrations of testosterone, DHEA, and progesterone across the period of 8-18 years of age...
February 12, 2018: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/29453817/endocrine-and-psychological-aspects-of-sexual-dysfunction-in-klinefelter-patients
#4
A Ferlin, R Selice, S Angelini, M Di Grazia, N Caretta, F Cavalieri, A Di Mambro, C Foresta
Klinefelter syndrome is a frequent cause of hypogonadism, but despite hundreds of publications on different aspects of Klinefelter syndrome, only a few studies dealt with sexual dysfunction. In particular, testosterone is critical for various aspects of sexual response, but its role on sexuality in Klinefelter syndrome patients is debatable and no studies have evaluated the efficacy of testosterone treatment on sexual dysfunction in these subjects. Furthermore, the impact of psychological and relational aspects on sexual function of Klinefelter syndrome subjects is poorly defined...
February 17, 2018: Andrology
https://www.readbyqxmd.com/read/29453202/management-of-endocrine-disease-hyperandrogenic-states-in-women-pitfalls-in-laboratory-diagnosis
#5
Michel Pugeat, Ingrid Plotton, Aude Brac de la Perrière, Gerald Raverot, Henri Déchaud, Véronique Raverot
Measuring total testosterone level is the first-line approach in assessing androgen excess in women. The main pitfalls in measuring testosterone relate to its low concentration and to the structural similarity between circulating androgens and testosterone, requiring accurate techniques with high specificity and sensitivity. These goals can be achieved by immunoassay using a specific anti-testosterone monoclonal antibody, ideally after an extraction step. Liquid chromatography coupled to tandem mass spectrometry (LC-MS/MS) will be commonly used for measuring testosterone, providing optimal accuracy with a low limit of detection...
February 16, 2018: European Journal of Endocrinology
https://www.readbyqxmd.com/read/29449314/vitamin-d-pcos-and-androgens-in-men-a-systematic-review
#6
Christian Trummer, Stefan Pilz, Verena Schwetz, Barbara R Obermayer-Pietsch, Elisabeth Lerchbaum
BACKGROUND: Accumulating evidence from animal and human studies suggests that vitamin D is involved in many functions of the reproductive system in both genders. AIM: The aim of this review was to provide an overview on the effects of vitamin D on polycystic ovary syndrome (PCOS) in women and androgen metabolism in men. METHODS: We performed a systematic literature search in Pubmed for relevant English language publications published from January 2012 until July 2017...
February 15, 2018: Endocrine Connections
https://www.readbyqxmd.com/read/29449081/urinary-concentrations-of-benzophenone-type-ultra-violet-light-filters-and-reproductive-parameters-in-young-men
#7
Evdochia Adoamnei, Jaime Mendiola, Miriam Moñino-García, Fernando Vela-Soria, Luz M Iribarne-Durán, Mariana F Fernández, Nicolás Olea, Niels Jørgensen, Shanna H Swan, Alberto M Torres-Cantero
BACKGROUND: Benzophenone (BP)-type ultraviolet (UV) light filters are chemicals frequently added to personal care products, insect repellents, sunscreens, and beverage and food packaging to diminish the harmful effects of UV sunlight on human skin or foodstuffs. BP-type UV filters have shown negative effects on male reproduction function in in vitro and animal models, but human epidemiologic studies are limited. The goal of this study was to examine associations between urinary concentrations of BP-type UV filters and semen quality and reproductive hormone levels...
February 9, 2018: International Journal of Hygiene and Environmental Health
https://www.readbyqxmd.com/read/29445518/why-do-endocrine-profiles-in-elite-athletes-differ-between-sports
#8
Peter H Sönksen, Richard I G Holt, Walailuck Böhning, Nishan Guha, David A Cowan, Christiaan Bartlett, Dankmar Böhning
Background: Endocrine profiles have been measured on blood samples obtained immediately post-competition from 693 elite athletes from 15 Olympic Sports competing at National or International level; four were subsequently excluded leaving 689 for the current analysis. Methods: Body composition was measured by bioimpedance in a sub-set of 234 (146 men and 88 women) and from these data a regression model was constructed that enabled 'estimated' lean body mass and fat mass to be calculated on all athletes...
2018: Clinical Diabetes and Endocrinology
https://www.readbyqxmd.com/read/29445187/adult-male-mice-exposure-to-nonylphenol-alters-courtship-vocalizations-and-mating
#9
Daphné Capela, Carlos Dombret, Kevin Poissenot, Manon Poignant, Aude Malbert-Colas, Isabelle Franceschini, Matthieu Keller, Sakina Mhaouty-Kodja
The neural circuitry processing male sexual behavior is tightly regulated by testosterone and its neural metabolite estradiol. The present study evaluated the effects of adult exposure to low doses of nonylphenol (NP), a widespread environmental contaminant, on the neuroendocrine regulation of testosterone and expression of sexual behavior. Oral exposure of C57BL/6J males to NP (0.5, 5 or 50 μg/kg/day) for 4 weeks did not affect circulating levels of testosterone or the kisspeptin system, a key regulator of the gonadotropic axis...
February 14, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29441000/self-confidence-overconfidence-and-prenatal-testosterone-exposure-evidence-from-the-lab
#10
Patricio S Dalton, Sayantan Ghosal
This paper examines whether foetal testosterone exposure predicts the extent of confidence and over-confidence in own absolute ability in adulthood. To study this question, we elicited incentive-compatible measures of confidence and over-confidence in the lab and correlate them with measures of right hand 2D:4D, used as as a marker for the strength of prenatal testosterone exposure. We provide evidence that men with higher prenatal testosterone exposure (i.e., low 2D:4D ratio) are less likely to set unrealistically high expectations about their own performance...
2018: Frontiers in Behavioral Neuroscience
https://www.readbyqxmd.com/read/29438723/discovery-and-development-of-odm-204-a-novel-nonsteroidal-compound-for-the-treatment-of-castration-resistant-prostate-cancer-by-blocking-the-androgen-receptor-and-inhibiting-cyp17a1
#11
REVIEW
Riikka Oksala, Anu Moilanen, Reetta Riikonen, Petteri Rummakko, Arja Karjalainen, Mikko Passiniemi, Gerd Wohlfahrt, Päivi Taavitsainen, Chira Malmström, Meri Ramela, Hanna-Maija Metsänkylä, Riikka Huhtaniemi, Pekka J Kallio, Mika Vj Mustonen
We report the discovery of a novel nonsteroidal dual-action compound, ODM-204, that holds promise for treating patients with castration-resistant prostate cancer (CRPC), an advanced form of prostate cancer characterised by high androgen receptor (AR) expression and persistent activation of the AR signaling axis by residual tissue androgens. For ODM-204, has a dual mechanism of action. The compound is anticipated to efficiently dampen androgenic stimuli in the body by inhibiting CYP17A1, the prerequisite enzyme for the formation of dihydrotestosterone (DHT) and testosterone (T), and by blocking AR with high affinity and specificity...
February 10, 2018: Journal of Steroid Biochemistry and Molecular Biology
https://www.readbyqxmd.com/read/29436770/a-review-of-the-role-of-estrogen-in-dermal-aging-and-facial-attractiveness-in-women
#12
REVIEW
Edwin D Lephart
Estrogens are known to have protective and favorable influences on skin health; conversely, androgens oppose the actions of estrogens. Estrogen's chemical messages are transmitted via the classical nuclear hormone estrogen receptors (ER) alpha and beta and the rapid-acting G-coupled membrane estrogen receptor. Androgens [both testosterone and 5α-dihydrotestosterone (5α-DHT)] bind the same androgen receptor. Estrogen levels peak in the mid- to late 20s in women and then decline by 50% by 50 years of age and dramatically decrease further after menopause...
February 13, 2018: Journal of Cosmetic Dermatology
https://www.readbyqxmd.com/read/29436386/limitations-of-insulin-resistance-assessment-in-polycystic-ovary-syndrome
#13
Krzysztof C Lewandowski, Justyna Płusajska, Wojciech Horzelski, Ewa Bieniek, Andrzej Lewinski
Backgroud: Though insulin resistance (IR) is common in polycystic ovary syndrome (PCOS), there is no agreement as to what surrogate method of assessment of IR is most reliable. SUBJECTS AND METHODS: In 478 women with PCOS we compared methods based on fasting insulin and either fasting glucose (HOMA-IR and QUICKI), or triglycerides (McAuley Index) with IR indices derived from glucose and insulin during OGTT (Belfiore, Matsuda and Stumvoll indices). RESULTS: There was a strong correlation between IR indices derived from fasting values HOMA-IR/QUICKI, r=-0...
February 7, 2018: Endocrine Connections
https://www.readbyqxmd.com/read/29434814/metformin-and-pioglitazone-combination-therapy-ameliorate-polycystic-ovary-syndrome-through-ampk-pi3k-jnk-pathway
#14
Yuanyuan Wu, Pengfen Li, Dan Zhang, Yingpu Sun
Polycystic ovary syndrome (PCOS) is a common gynecological endocrine disorder, which results in health problems such as menstrual disorders, hyperandrogenism and persistent anovulation. Hyperandrogenism and insulin resistance are the basic characteristics of PCOS. To investigate the combined effect of metformin and pioglitazone on POCS and the potential mechanisms, a rat model of PCOS was established by intramuscular injection of estradiol valerate (EV). The effect of metformin and pioglitazone monotherapy or combination therapy in control rats and PCOS rats was evaluated, involving the testosterone level, follicular development and insulin resistance...
February 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29428315/association-of-testosterone-and-antim%C3%A3-llerian-hormone-with-time-to-pregnancy-and-pregnancy-loss-in-fecund-women-attempting-pregnancy
#15
Lindsey A Sjaarda, Sunni L Mumford, Daniel L Kuhr, Tiffany L Holland, Robert M Silver, Torie C Plowden, Neil J Perkins, Enrique F Schisterman
OBJECTIVE: To examine whether higher T and/or antimüllerian hormone (AMH) was associated with anovulation, time to pregnancy (TTP), or pregnancy loss risk among healthy, fecund women without diagnosed polycystic ovary syndrome. DESIGN: Prospective cohort study conducted as a secondary analysis from the Effects of Aspirin in Gestation and Reproduction randomized trial. SETTING: University medical centers. PATIENT(S): A total of 1,198 healthy, eumenorrheic women aged 18-40 years attempting spontaneous pregnancy with one to two prior pregnancy losses were included...
February 7, 2018: Fertility and Sterility
https://www.readbyqxmd.com/read/29425972/a-longitudinal-analysis-of-salivary-testosterone-concentrations-and-competitiveness-in-elite-and-non-elite-women-athletes
#16
Blair T Crewther, Christian J Cook
BACKGROUND: There is evidence linking women's T to competitive behaviours in sport and exercise. To advance this work, we examined the longitudinal relationships between salivary testosterone (sal-T) and competitiveness in athletic women who differ in training status. METHODS: Elite (n = 9) and non-elite (n = 21) women athletes were monitored on days 6-8 (follicular phase), 13-15 (ovulatory phase) and 20-22 (Luteal phase) of a menstrual cycle with two repeats...
February 6, 2018: Physiology & Behavior
https://www.readbyqxmd.com/read/29425971/competition-stage-influences-perceived-performance-but-does-not-affect-rating-of-perceived-exertion-and-salivary-neuro-endocrine-immune-markers-in-elite-young-basketball-players
#17
Ademir Felipe Schultz de Arruda, Marcelo Saldanha Aoki, Ana Carolina Paludo, Gustavo Drago, Alexandre Moreira
This study examined the effects of competition stage on the salivary concentration of testosterone (T), cortisol (C), alpha-amylase (sAA), and IL-1ß cytokine, perceived performance (PP) and session rating of perceived exertion (session-RPE) in elite youth basketball players (age, 15.8 ± 0.8 yrs.; stature, 190.9 ± 7.9 cm; body mass, 90.0 ± 16.9 kg) from two age-categories (U16; n = 7; U17; n = 7). Two winning playoff matches (FM; playing for the championship; 1 for each age-category) and two winning regular stage matches (RM; 1 for each age category, played against opponents ranked 2nd place), were assessed in the current study...
February 6, 2018: Physiology & Behavior
https://www.readbyqxmd.com/read/29421333/the-urinary-metabolites-of-dinch%C3%A2-have-an-impact-on-the-activities-of-the-human-nuclear-receptors-er%C3%AE-er%C3%AE-ar-ppar%C3%AE-and-ppar%C3%AE
#18
Anika Engel, Thorsten Buhrke, Stefanie Kasper, Anne-Cathrin Behr, Albert Braeuning, Sönke Jessel, Albrecht Seidel, Wolfgang Völkel, Alfonso Lampen
DINCH® (di-isononyl cyclohexane-1,2-dicarboxylate) is a non-phthalate plasticizer that has been developed to replace phthalate plasticizers such as DEHP (di-2-ethylhexyl phthalate) or DINP (di-isononyl phthalate). DINCH® is metabolized to its corresponding monoester and subsequently to oxidized monoester derivatives. These are conjugated to glucuronic acid and subject to urinary excretion. In contrast to DINCH®, there are almost no toxicological data available regarding its primary and secondary metabolites...
February 5, 2018: Toxicology Letters
https://www.readbyqxmd.com/read/29417863/marmoset-cytochrome-p450-2b6-a-propofol-hydroxylase-expressed-in-liver
#19
Toru Oshio, Shotaro Uehara, Yasuhiro Uno, Takashi Inoue, Erika Sasaki, Hiroshi Yamazaki
1. The common marmoset (Callithrix jacchus) is a useful experimental animal to evaluate the pharmacokinetics of drug candidates. Cytochrome P450 (P450) 2B enzyme in marmoset livers has been identified; however, only limited information on the enzymatic properties and distribution has been available. 2. Marmoset P450 2B6 amino acids showed high sequence identities (>86%) with those of primates including humans and cynomolgus monkeys. Phylogenetic analysis using amino acid sequences indicated that marmoset P450 2B6 was closer to human and cynomolgus monkey P450 2B6 than to P450 2B orthologs of other species, including pigs, dogs, rabbits, and rodents...
February 8, 2018: Xenobiotica; the Fate of Foreign Compounds in Biological Systems
https://www.readbyqxmd.com/read/29412390/growth-hormone-deficiency-with-advanced-bone-age-phenotypic-interaction-between-ghrh-receptor-and-cyp21a2-mutations-diagnosed-by-sanger-and-whole-exome-sequencing
#20
Fernanda A Correa, Marcela M França, Qing Fang, Qianyi Ma, Tania A Bachega, Andresa Rodrigues, Bilge A Ozel, Jun Z Li, Berenice B Mendonca, Alexander A L Jorge, Luciani R Carvalho, Sally A Camper, Ivo J P Arnhold
Isolated growth hormone deficiency (IGHD) is the most common pituitary hormone deficiency and, clinically, patients have delayed bone age. High sequence similarity between CYP21A2 gene and CYP21A1P pseudogene poses difficulties for exome sequencing interpretation. A 7.5 year-old boy born to second-degree cousins presented with severe short stature (height SDS -3.7) and bone age of 6 years. Clonidine and combined pituitary stimulation tests revealed GH deficiency. Pituitary MRI was normal. The patient was successfully treated with rGH...
December 2017: Archives of Endocrinology and Metabolism
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