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https://www.readbyqxmd.com/read/29042336/physicochemical-properties-of-inclusion-complexes-of-highly-soluble-%C3%AE-cyclodextrins-with-highly-hydrophobic-testosterone-propionate
#1
Christian Celia, Angela Scala, Rosanna Stancanelli, Emanuela Surdo, Donatella Paolino, Alessandro Grattoni, Nicola Micale, Vincenza Crupi, Domenico Majolino, Massimo Fresta, Silvana Tommasini, Valentina Venuti, Cinzia Anna Ventura
Hydroxypropyl-β-cyclodextrin (HP-β-CyD) and sulfobutyl ether-β-cyclodextrin (SBE-β-CyD) were used to generate hydrophilic complexes of the poorly water-soluble drug testosterone propionate (TP). The inclusion complexes were obtained by freeze-drying, and then analyzed at both liquid and solid states. Phase solubility studies, performed according to the type-AL solubility diagrams of TP in presence of both CyDs, suggested the formation of water-soluble complexes at 1:1 molar ratio. These results were confirmed by continuous variation method (Job's plot)...
October 14, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/29039422/drug-development-for-noncastrate-prostate-cancer-in-a-changed-therapeutic-landscape
#2
REVIEW
Min Yuen Teo, Matthew J O'Shaughnessy, Sean M McBride, Herbert A Vargas, Howard I Scher
The unprecedented progress in the treatment of metastatic castration-resistant prostate cancer is only beginning to be realized in patients with noncastrate disease. This slow progress in part reflects the use of trial objectives focused on time-to-event end points, such as time to metastasis and overall survival, which require long follow-up durations and large sample sizes, and has been further delayed by the use of approved therapies that are effective at the time of progression. Our central hypotheses are that progress can be accelerated, and that outcomes can be improved by shifting trial objectives to response measures occurring early that solely reflect the effects of the treatment...
October 17, 2017: Nature Reviews. Clinical Oncology
https://www.readbyqxmd.com/read/29037971/to-fight-or-mate-hormonal-control-of-sex-recognition-male-sexual-behavior-and-aggression-in-the-gecko-lizard
#3
Tereza Schořálková, Lukáš Kratochvíl, Lukáš Kubička
Squamate reptiles are a highly diversified vertebrate group with extensive variability in social behavior and sexual dimorphism. However, hormonal control of these traits has not previously been investigated in sufficient depth in many squamate lineages. Here, we studied the hormonal control of male sexual behavior, aggressiveness, copulatory organ (hemipenis) size and sex recognition in the gecko Paroedura picta, comparing ovariectomized females, ovariectomized females treated with exogenous dihydrotestosterone (DHT), ovariectomized females treated with exogenous testosterone (T), control females and males...
October 13, 2017: Hormones and Behavior
https://www.readbyqxmd.com/read/29037103/ameliorative-effect-of-myo-inositol-on-red-blood-cell-alterations-in-polycystic-ovary-syndrome-in-vitro-study
#4
Alessandra Andrisani, Gabriella Donà, Chiara Sabbadin, Elena Tibaldi, Francesco Dessole, Valentina Bosello Travain, Loris Marin, Anna Maria Brunati, Guido Ambrosini, Decio Armanini, Eugenio Ragazzi, Luciana Bordin
Polycystic ovary syndrome (PCOS)is a gynecological endocrine disorder which is associated with systemic inflammatory status inducing red blood cells (RBC) membrane alterations related to insulin resistance and testosterone levels which could be greatly improved by myo-inositol (MYO) uptake. In this study we aim to evaluate the effect of MYO in reducing oxidative-related alterations through in vitro study on PCOS RBC. Blood samples from two groups of volunteers, control group (CG, n = 12) and PCOS patient group (PG, n = 12), were analyzed for band 3 tyrosine phosphorylation (Tyr-P), high molecular weight aggregate (HMWA), IgG in RBC membranes, and glutathione (GSH) in cytosol, following O/N incubation in the presence or absence of MYO...
October 16, 2017: Gynecological Endocrinology
https://www.readbyqxmd.com/read/29034488/exploiting-whole-genome-sequence-data-to-fine-map-and-characterize-candidate-genes-within-a-quantitative-trait-loci-region-affecting-androstenone-on-porcine-chromosome-5
#5
M van Son, R Agarwal, M P Kent, H Grove, E Grindflek, S Lien
Male piglets are routinely castrated to eliminate boar taint. However, this treatment is undesirable, and alternative approaches, including genetic strategies to reduce boar taint, are demanded. Androstenone is one of the causative agents of boar taint, and a QTL region affecting this pheromone has previously been reported on SSC5: 22.6-24.8 Mb in Duroc. The QTL region is one of the few reported for androstenone that does not simultaneously affect levels of other sex steroids. The main objective of this study was to fine map this QTL...
October 16, 2017: Animal Genetics
https://www.readbyqxmd.com/read/29034138/testosterone-pellet-associated-dermatitis-report-and-review-of-testopel-related-cutaneous-adverse-effects
#6
Lucas A Heldt Manica, Philip R Cohen
Testosterone replacement therapy is a treatment utilized for male hypogonadism. A subcutaneous testosterone pellet is a long-acting, slow-release delivery system that can be utilized as androgen replacement therapy. A 77-year-old man who was treated with testosterone pellets developed dermatitis consisting of erythematous plaques and patches on both buttocks and thighs within 28 days following the subcutaneous insertion of testosterone pellets. The skin lesions rapidly resolved with high-potency topical corticosteroid application...
August 11, 2017: Curēus
https://www.readbyqxmd.com/read/29029242/germ-cell-neoplasia-in-situ-and-preserved-fertility-despite-suppressed-gonadotropins-in-a-patient-with-testotoxicosis
#7
Li Juel Mortensen, Martin Blomberg Jensen, Peter Christiansen, Ann-Margrethe Rønholt, Anne Jørgensen, Hanne Frederiksen, John E Nielsen, Anand C Loya, Birgitte Grønkær Toft, Niels E Skakkebæk, Ewa Rajpert-De Meyts, Anders Juul
Context: Testotoxicosis is an autosomal dominant, male-limited disorder. Activating mutations in the Luteinizing Hormone Receptor gene (LHCGR) cause high autonomous testosterone secretion resulting in early-onset peripheral precocious puberty. Little is known about long-term consequences of testotoxicosis. Case Description: We present a rare case of a patient followed for 25 years with two remarkable outcomes; preserved fertility and germ cell neoplasia in situ (GCNIS)...
October 5, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29026762/correlation-of-vitamin-d-with-metabolic-parameters-in-polycystic-ovarian-syndrome
#8
Arun Kumar, Satish Barki, Vinod Raghav, Ashutosh Chaturvedi, K V S Hari Kumar
BACKGROUND: Polycystic ovarian syndrome (PCOS) and hypovitaminosis D are the two most common endocrine disorders in young women leading to many adverse metabolic consequences. We evaluated the correlation of 25-hydroxy Vitamin D (25OHD) with metabolic parameters and insulin resistance in PCOS. MATERIALS AND METHODS: We included 100 PCOS patients (age 18-40 years, duration >6 months) serially, in this cross-sectional study. We excluded patients with past use of insulin sensitizers and hormone therapy...
January 2017: Journal of Family Medicine and Primary Care
https://www.readbyqxmd.com/read/29025356/associations-between-sleep-deprivation-and-salivary-testosterone-levels-in-male-university-students-a-prospective-cohort-study
#9
Mahmoud Suleiman Abu-Samak, Beisan Ali Mohammad, May Ibrahim Abu-Taha, Luai Zidan Hasoun, Shady Helmi Awwad
Sleep deprivation is a common health problem that is growing rapidly worldwide and it is associated with short- and long-term impacts on health. The aim of this study was to detect potential predictors of salivary testosterone (sT) association with sleep deprivation in Arab male university students. In this prospective cohort study, 77 university male students in the age range of 18 to 26 years were divided into two groups, sleep-deprived (SD) participants and non-sleep-deprived (NSD) participants. Sleep deprivation was defined as sleeping less than 5 hr per night...
October 1, 2017: American Journal of Men's Health
https://www.readbyqxmd.com/read/29023546/steroid-hormones-and-psychological-responses-to-soccer-matches-insights-from-a-systematic-review-and-meta-analysis
#10
Maamer Slimani, Julien S Baker, Foued Cheour, Lee Taylor, Nicola Luigi Bragazzi
The present systematic review and meta-analysis aimed to assess the perturbations in hormonal and psychological homeostasis in response to soccer match-play. These perturbations were explored according to match outcome (i.e., win versus loss), gender, type of contest (i.e., competitive versus non-competitive fixtures) and competitive level (i.e., novice versus high-level). The review was conducted according to the Population/Intervention or Exposure/Comparison/Outcome(s) (PICO) criteria and the Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) guidelines...
2017: PloS One
https://www.readbyqxmd.com/read/29019074/in-vitro-inhibitory-effect-of-gymnema-sylvestre-extracts-and-total-gymnemic-acids-fraction-on-select-cytochrome-p450-activities-in-rat-liver-microsomes
#11
Madhuri Vaghela, Krishna Iyer, Nancy Pandita
BACKGROUND AND OBJECTIVES: Gymnema sylvestre R. Br. is a well-known Indian medicinal herb. Gymnemic acids are pentacyclic triterpenes saponins and active phytoconstituents of Gymnema sylvestre. The study aimed at evaluation of the in vitro rat liver cytochrome P450 (CYP) inhibition potential of extracts and total gymnemic acid (TA)-enriched fractions from G. sylvestre. METHODS: Standardization of G. sylvestre [ethanolic (EL), hydroethanolic (HE), total acid of ethanolic (TAE), total acid of hydroethanolic (TAHE) and total acid of aqueous (TAAQ) extract] was done with respect to deacyl gymnemic acid (DAGA), using reverse phase-high performance liquid chromatography (RP-HPLC)...
October 10, 2017: European Journal of Drug Metabolism and Pharmacokinetics
https://www.readbyqxmd.com/read/29018905/cyp109e1-is-a-novel-versatile-statin-and-terpene-oxidase-from-bacillus-megaterium
#12
Natalia Putkaradze, Martin Litzenburger, Ammar Abdulmughni, Mohammed Milhim, Elisa Brill, Frank Hannemann, Rita Bernhardt
CYP109E1 is a cytochrome P450 monooxygenase from Bacillus megaterium with a hydroxylation activity for testosterone and vitamin D3. This study reports the screening of a focused library of statins, terpene-derived and steroidal compounds to explore the substrate spectrum of this enzyme. Catalytic activity of CYP109E1 towards the statin drug-precursor compactin and the prodrugs lovastatin and simvastatin as well as biotechnologically relevant terpene compounds including ionones, nootkatone, isolongifolen-9-one, damascones, and β-damascenone was found in vitro...
October 11, 2017: Applied Microbiology and Biotechnology
https://www.readbyqxmd.com/read/28994096/impaired-expression-of-testicular-androgen-receptor-and-collagen-fibers-in-the-testis-of-diabetic-rats-under-haart-the-role-of-hypoxis-hemerocallidea
#13
Onanuga O Ismail, Jegede I Ayoola, Offor Ugochukwu, Ogedengbe O Oluwatosin, Peter I Aniekan, Naidu C S Edwin, Azu O Onyemaechi
INTRODUCTION: Wide spectrum of alterations associated with highly active antiretroviral therapy (HAART) has been reported. The current study aimed at evaluating the role of Hypoxis hemerocallidea (HH) aqueous extract on the testosterone levels, expression of androgen receptors and collagen fibers in the testes of streptozotocin-nicotinamide-induced diabetic rats under HAART regimen. MATERIAL AND METHODS: Sixty two adult male Sprague-Dawley rats (189.0 ± 4.5 g) were divided into eight groups (8 animals in each treatment groups and 6 rats in the control group)...
October 10, 2017: Folia Histochemica et Cytobiologica
https://www.readbyqxmd.com/read/28989874/metabolic-status-and-hypogonadism-in-human-immunodeficiency-virus-infected-males
#14
Sarita Bajaj, Yashaswi Pathak, Sharad Varma, Sujit Verma
AIMS AND OBJECTIVES: The aim of this study is to determine the prevalence of hypogonadism in human immunodeficiency virus (HIV)-infected males and to study its relation to age, CD4 count, body mass index (BMI), duration of highly active antiretroviral therapy (HAART), and metabolic status. METHODOLOGY: Eighty-one HIV positive cases and 82 healthy controls were included in this case-control study. Each case underwent a complete physical examination and serum fasting plasma glucose, A1c, lipid profile, total testosterone (TT), follicle-stimulating hormone (FSH), and luteinizing hormone (LH) levels were estimated...
September 2017: Indian Journal of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28988314/the-prostate-response-to-prolactin-modulation-in-adult-castrated-rats-subjected-to-testosterone-replacement
#15
Flávia B Constantino, Ana C L Camargo, Sérgio A A Santos, Ketlin T Colombelli, Laura F Martin, Marcia G Silva, Sérgio L Felisbino, Luis A Justulin
Despite the androgenic dependence, other hormones, growth factors, and cytokines are necessary to support prostatic growth and maintain the glandular structure; among them, prolactin is a non-steroidal hormone secreted mainly by the pituitary gland. However, extra-pituitary expression of prolactin, such as in the prostate, has also been demonstrated, highlighting the paracrine and autocrine actions of prolactin within the prostate. Here, we investigated whether prolactin modulation alters ventral prostate (VP) morphophysiology in adult castrated rats...
October 7, 2017: Journal of Molecular Histology
https://www.readbyqxmd.com/read/28986080/chronic-nitrate-exposure-alters-reproductive-physiology-in-fathead-minnows
#16
Kristen A Kellock, Adrian P Moore, Robert B Bringolf
Nitrate is a ubiquitous aquatic pollutant that is commonly associated with eutrophication and dead zones in estuaries around the world. At high concentrations nitrate is toxic to aquatic life but at environmental concentrations it has also been purported as an endocrine disruptor in fish. To investigate the potential for nitrate to cause endocrine disruption in fish, we conducted a lifecycle study with fathead minnows (Pimephales promelas) exposed to nitrate (0, 11.3, and 56.5 mg/L (total nitrate-nitrogen (NO3-N)) from <24 h post hatch to sexual maturity (209 days)...
October 3, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/28985183/the-effect-of-celery-apium-graveolens-l-on-fertility-a-systematic-review
#17
Wesam Kooti, Maryam Moradi, Khadijeh Peyro, Maedeh Sharghi, Fatima Alamiri, Milad Azami, Mohammad Firoozbakht, Mehri Ghafourian
Background Fertility and infertility problems are among the complex issues in medicine. The use of herbal products in the treatment of fertility has been considered as an alternative to synthetic drugs. Celery containing known compounds can have an impact on the fertility rate. The aim of this study was to do a systematic review on conducted studies in conjunction with the celery and reproduction. Methods Required papers were searched from databases like Science direct, PubMed, Scopus, and Springer. Keywords used in this study were "Apium graveolens L...
October 6, 2017: Journal of Complementary & Integrative Medicine
https://www.readbyqxmd.com/read/28982870/both-high-and-low-serum-total-testosterone-levels-indicate-poor-prognosis-in-patients-with-prostate-cancer
#18
Kouji Izumi, Kazuyoshi Shigehara, Takahiro Nohara, Kazutaka Narimoto, Yoshifumi Kadono, Atsushi Mizokami
BACKGROUND/AIM: Androgen-androgen receptor (AR) signal is known as a powerful driver of prostate cancer progression. We previously reported the limitation of prostate-specific antigen (PSA) at diagnosis as a prognostic biomarker of prostate cancer. Although serum total testosterone (TT) level has been reported as a prognostic biomarker for prostate cancer, its usability is still controversial. We examined the potential and characteristics of TT as a biomarker. PATIENTS AND METHODS: Serum TT levels of patients who underwent prostate biopsy were measured, and prostate cancer-specific survival (PCaSS), overall survival (OS), and the correlation between staging and serum TT level were analyzed...
October 2017: Anticancer Research
https://www.readbyqxmd.com/read/28978458/a-crossover-crossback-prospective-study-of-dibutyl-phthalate-exposure-from-mesalamine-medications-and-serum-reproductive-hormones-in-men
#19
Feiby L Nassan, Brent A Coull, Niels E Skakkebaek, Anna-Maria Andersson, Michelle A Williams, Lidia Mínguez-Alarcón, Stephen A Krawetz, Janet E Hall, Elizabeth J Hait, Joshua R Korzenik, Jennifer B Ford, Alan C Moss, Russ Hauser
BACKGROUND: Phthalates, such as dibutyl phthalate (DBP), are endocrine disruptors used in some medication coatings e.g., mesalamine to treat inflammatory bowel disease (IBD). OBJECTIVES: Taking advantage of different mesalamine formulations with/without DBP, we assessed whether DBP from mesalamine (>1000x background) altered serum hormones. METHODS: Men (N=73) with IBD participated in a crossover-crossback prospective study and provided up to 6 serum samples (2:baseline, 2:crossover, 2:crossback)...
October 1, 2017: Environmental Research
https://www.readbyqxmd.com/read/28977728/intraductal-carcinoma-of-the-prostate-can-evade-androgen-deprivation-with-emergence-of-castrate-tolerant-cells
#20
Laura H Porter, Kohei Hashimoto, Mitchell G Lawrence, Carmel Pezaro, David Clouston, Hong Wang, Melissa Papargiris, Heather Thorne, Jason Li, Andrew Ryan, Sam Norden, Daniel Moon, Damien M Bolton, Shomik Sengupta, Mark Frydenberg, Declan G Murphy, Gail P Risbridger, Renea A Taylor
OBJECTIVES: To determine the relevance of intraductal carcinoma of the prostate (IDC-P) in advanced prostate cancer, we first examined whether IDC-P was originally present in patients who later developed advanced prostate cancer and then used patient-derived xenografts (PDXs) to investigate the response of IDC-P to androgen deprivation therapy (ADT). MATERIALS AND METHODS: We conducted a retrospective pathology review of IDC-P in primary prostate biopsy or surgery specimens from 38 men who subsequently developed advanced prostate cancer...
October 4, 2017: BJU International
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