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gastrectomy D2

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https://www.readbyqxmd.com/read/29290772/adjuvant-chemotherapy-improves-survival-in-stage-iii-gastric-cancer-after-d2-surgery
#1
Shin-Chun Chang, Keng-Hao Liu, Chia-Yen Hung, Chun-Yi Tsai, Jun-Te Hsu, Ta-Sen Yeh, Jen-Shi Chen, Yung-Chia Kuo, Yu-Shin Hung, Wen-Chi Chou
Background: Stage III gastric cancer is characterized by locally advanced disease with varying anatomic extent as measured by the 7th edition of the American Joint Committee on Cancer (AJCC) staging system. There are no prognostic factors specifically identified in patients with stage III gastric cancer following extended lymph node dissection (D2) surgery. Materials and Methods: From 2007 to 2014, 534 patients with stage III gastric cancer underwent radical gastrectomy and D2 dissection at the Chang Gung Memorial Hospital...
2018: Journal of Cancer
https://www.readbyqxmd.com/read/29288614/laparoscopic-hipec-for-peritoneal-carcinomatosis-from-gastric-cancer-technique-and-early-outcomes-of-our-first-cases
#2
Irina Bălescu, Daniela Godoroja, Mircea Gongu, Victor Tomulescu, Cătălin Copăescu
Gastric cancer remains one of the most aggressive malignancies, being associated with very poor therapeutic outcomes, especially in the advanced disease patients. Due to this evidence, finding a better treatment, a better control and higher survival rates is the current scientific focus of the medical community. Once the benefits of cytoreductive surgery in association with intraperitoneal hyperthermy (HIPEC) have been widely demonstrated in patients presenting peritoneal carcinomatosis from colorectal or ovarian origin,attention was focused on the possible benefit of this method in patients diagnosed with peritoneal carcinomatosis with gastric origin...
November 2017: Chirurgia
https://www.readbyqxmd.com/read/29282515/impact-of-the-weekday-of-surgery-on-outcome-in-gastric-cancer-patients-who-underwent-d2-gastrectomy
#3
Felix Berlth, K Messerle, P S Plum, S-H Chon, J von Ambüren, A Hohn, M Dübbers, C J Bruns, S P Mönig, E Bollschweiler, A H Hölscher, H Alakus
BACKGROUND: The impact of the weekday of surgery in major elective cases of the upper-GI has been discussed controversially. The objective of this study was to assess whether weekday of surgery influences outcome in patients undergoing D2-gastrectomy. MATERIALS AND METHODS: Patients who underwent D2-gastrectomy for gastric adenocarcinoma between 1996 and 2016 were included. Weekday of surgery was recognized, and subgroups were analyzed regarding clinical and histopathological differences...
December 28, 2017: World Journal of Surgery
https://www.readbyqxmd.com/read/29251364/after-neoadjuvant-chemotherapy-platelet-lymphocyte-ratios-negatively-correlate-with-prognosis-in-gastric-cancer-patients
#4
Weipeng Gong, Lei Zhao, Zhaogang Dong, Yu Dou, Yanguo Liu, Chao Ma, Xun Qu
INTRODUCTION: Circulating predictors prognostic factors of neoadjuvant chemotherapy, which identify the patients who are potential possibly to benefit from it are limited at present. In this research, we aimed to compare the prognostic significance of neutrophil/lymphocyte ratio (NLR) and platelet/lymphocyte ratio (PLR) in patients with locally advance gastric carcinoma who were treated with neoadjuvant chemotherapy (NAC) followed by D2 gastrectomy. MATERIALS AND METHODS: From 2007 to 2015, 91 patients with locally advanced gastric cancer treated with NAC followed by D2 gastrectomy included in this retrospective cohort study...
December 18, 2017: Journal of Clinical Laboratory Analysis
https://www.readbyqxmd.com/read/29234941/short-term-surgical-outcomes-of-a-randomized-controlled-trial-comparing-laparoscopic-versus-open-gastrectomy-with-d2-lymph-node-dissection-for-advanced-gastric-cancer
#5
Yan Shi, Xianhui Xu, Yongliang Zhao, Feng Qian, Bo Tang, Yingxue Hao, Huaxing Luo, Jun Chen, Peiwu Yu
BACKGROUND: Laparoscopy-assisted gastrectomy (LAG) has gained acceptance as one of the best treatments for early gastric cancer. However, the application of LAG with D2 lymph node dissection in patients with locally advanced gastric cancer (AGC) remains controversial. METHODS: We launched a prospective randomized controlled trial comparing laparoscopic and open gastrectomy with D2 lymph node dissection for locally AGC to evaluate technical safety and oncologic feasibility...
December 12, 2017: Surgical Endoscopy
https://www.readbyqxmd.com/read/29234894/amputation-neuroma-mimicking-lymph-node-metastasis-of-remnant-gastric-cancer-a-case-report
#6
Kenichiro Furukawa, Yutaka Tanizawa, Kimihide Kusafuka, Noriyuki Nishiwaki, Keiichi Fujiya, Hayato Omori, Sanae Kaji, Makoto Hikage, Rie Makuuchi, Tomoyuki Irino, Masanori Tokunaga, Etsuro Bando, Taiichi Kawamura, Masanori Terashima
BACKGROUND: Amputation neuromas (ANs) are reactive hyperplasia of nerve tissues that occur after a trauma or surgery involving the peripheral nerves. Only two previous reports of ANs occurring around the stomach and post gastrectomy have been reported. We report the case of a patient with AN near the remnant stomach who underwent distal gastrectomy for gastric cancer. CASE PRESENTATION: A 76-year-old man underwent distal gastrectomy, D1+ lymphadenectomy, and Billroth-I reconstruction for early gastric cancer in another hospital at 63 years of age...
December 12, 2017: Surgical Case Reports
https://www.readbyqxmd.com/read/29211699/robotic-versus-laparoscopic-gastrectomy-for-locally-advanced-gastric-cancer
#7
Hua-Feng Pan, Gang Wang, Jiang Liu, Xin-Xin Liu, Kun Zhao, Xiao-Fei Tang, Zhi-Wei Jiang
Robotic gastrectomy (RG) has progressed rapidly in the last decade, overcoming many obstacles in laparoscopic technology. We compared surgical performance and short-term clinical outcomes between RG and laparoscopic gastrectomy (LG). In total, 163 patients with gastric cancer were randomly treated with RG (n=102) or LG (n=61). D2 lymphadenectomy was achieved in all patients. Digestive tract reconstruction in the RG group was performed by intracorporeal hand sewing, but extracorporeal anastomosis in the LG group was performed with a 25-mm circular stapler or linear stapler...
December 2017: Surgical Laparoscopy, Endoscopy & Percutaneous Techniques
https://www.readbyqxmd.com/read/29178099/-analysis-of-risk-factors-on-pulmonary-infection-after-d2-lymphadenectomy-gastrectomy-for-gastric-cancer
#8
Xiaoguang Han, Zhaode Bu, Jiafu Ji
OBJECTIVE: To explore the risk factors of pulmonary infection after D2 radical gastrectomy of gastric cancer in order to guide clinical measures to reduce the incidence of pulmonary infection. METHODS: Clinical data of 371 patients undergoing D2 radical gastrectomy at Division 2 of Gastrointestinal Cancer Center from October 2014 to October 2016 were collected for retrospective cohort study. Associated risk factors of pulmonary infection after D2 radical gastrectomy of gastric cancer were analyzed...
November 25, 2017: Zhonghua Wei Chang Wai Ke za Zhi, Chinese Journal of Gastrointestinal Surgery
https://www.readbyqxmd.com/read/29167831/laparoscopic-distal-gastrectomy-with-d2-lymphadenectomy-followed-by-intracorporeal-gastroduodenostomy-for-advanced-gastric-cancer-technical-guide-and-tips
#9
REVIEW
Sang-Woong Lee, Masaru Kawai, Keitaro Tashiro, George Bouras, Satoshi Kawashima, Ryo Tanaka, Eiji Nomura, Kazuhisa Uchiyama
In 1994, Kitano and colleagues first reported laparoscopy-assisted Billroth I gastrectomy. Since then, laparoscopic gastrectomy (LG) has been associated with earlier patient recovery compared with open surgery, and has gained increasing international acceptance. Japan Society of Endoscopic Surgery biennial surveys confirm the increasing use of laparoscopic procedures for treatment of gastric cancer in Japan. Its thirteenth national survey indicates that of 31,264 patients treated at Japanese institutions in 2015, approximately 9,500 (30...
2017: Translational Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/29138379/-a-case-of-advanced-gastric-cancer-responding-to-neoadjuvant-chemotherapy-with-docetaxel-cisplatin-and-5-fluorouracil-leading-to-a-pathological-complete-response
#10
Keishi Kawasaki, Dan Takeuchi, Takaaki Kaneko, Seiki Miura, Junichiro Kamiya, Yoji Miyahara, Kotaro Yoshimura, Akira Ogata
We report a 72-year-old woman who was initially diagnosed with locally advanced gastric cancer with involvement of the esophagus and pancreas. She received 3 courses of neoadjuvant chemotherapy(NAC)with docetaxel, cisplatin, and 5- fluorouracil(the DCF regimen)and achieved an excellent response. She underwent total gastrectomy with distal pancreatectomy, splenectomy, and D2 lymphadenectomy. Histological examination confirmed a pathological complete response. NAC chemotherapy can down stage/down size the disease and allow some patients to undergo curative radical surgery...
November 2017: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/29137444/impact-of-splenic-hilar-lymph-node-metastasis-on-prognosis-in-patients-with-advanced-gastric-cancer
#11
Taeil Son, In Gyu Kwon, Joong Ho Lee, Youn Young Choi, Hyoung-Il Kim, Jae-Ho Cheong, Sung Hoon Noh, Woo Jin Hyung
Background: Impact of splenic hilar LN dissection during total gastrectomy for proximal advanced gastric cancer is controversial. The objective of this study was to assess the impact on prognosis of splenic hilar lymph node(LN) metastasis compared to that of metastasis to other regional LN groups. Study Design: Patients who underwent total gastrectomy with D2 LN dissection from 2000 to 2010 were reviewed retrospectively. The clinicopathologic characteristics and long-term results of patients with splenic hilar LN metastasis were compared to those of patients with only metastasis to other extraperigastric LNs (stations #8a, #9, #11, or #12a)...
October 13, 2017: Oncotarget
https://www.readbyqxmd.com/read/29135363/total-and-subtotal-laparoscopic-gastrectomy-for-the-treatment-of-advanced-gastric-cancer-morbidity-and-oncological-outcomes
#12
Stefano Olmi, Riccardo Giorgi, Stefano Piero Bernardo Cioffi, Matteo Uccelli, Roberta Villa, Francesca Ciccarese, Bruno Scotto, Giorgio Castello, Gianluca Legnani, Giovanni Cesana
BACKGROUND: A debate is still surrounding the use of laparoscopic surgery for advanced gastric cancer (AGC) related to doubts about the requirements to satisfy oncologic criteria. The aim of this study is to analyze the oncological results, the intraoperative complications, and the short- and medium-term morbidity and mortality in patients with AGC who underwent subtotal laparoscopic gastrectomy (SLG) or total laparoscopic gastrectomy (TLG) with extended lymphadenectomy. MATERIALS AND METHODS: We reviewed medical records of patients who underwent radical gastrectomy for AGC started laparoscopically with the intent of curative surgery, between July 2007 and October 2015...
November 14, 2017: Journal of Laparoendoscopic & Advanced Surgical Techniques. Part A
https://www.readbyqxmd.com/read/29130233/-clinical-features-and-prognosis-analysis-of-21-gastric-cancer-patients-with-pathological-complete-response-after-neoadjuvant-chemotherapy
#13
Liangqun Peng, Wei Yang, Zhandong Zhang, Hongxing Liu, Yawei Hua
OBJECTIVE: To evaluate the clinical features and prognosis of gastric cancer patients with pathological complete response (pCR) after neoadjuvant chemotherapy (NAC). METHODS: Clinical data of 159 gastric cancer patients who received NAC followed by surgical resection between January 2012 and December 2014 at the Affiliated Tumor Hospital of Zhengzhou University were collected and clinical features of those with pCR were analyzed retrospectively. Kaplan-Meier method was used to estimate 3-year overall survival (OS) rate and recurrence-free survival (RFS) rate...
October 25, 2017: Zhonghua Wei Chang Wai Ke za Zhi, Chinese Journal of Gastrointestinal Surgery
https://www.readbyqxmd.com/read/29124550/gastrectomy-with-extended-lymphadenectomy-a-north-american-perspective
#14
Alexandre Gosselin-Tardif, Jessica Lie, Ioana Nicolau, Juan Carlos Molina, Jonathan Cools-Lartigue, Liane Feldman, Jonathan Spicer, Carmen Mueller, Lorenzo Ferri
PURPOSE: Despite evidence of oncologic benefits from extended (D2) lymphadenectomy in gastric cancer from many East Asian studies, there is persistent debate over its use in the West, mainly due to perceived high rates of morbidity and mortality. This study evaluates the safety and efficacy of D2 dissection in a high-volume North American center. METHODS: A prospectively entered database of all patients undergoing gastrectomy for cancer at a North American referral center from 2005 to 2016 was reviewed...
November 9, 2017: Journal of Gastrointestinal Surgery: Official Journal of the Society for Surgery of the Alimentary Tract
https://www.readbyqxmd.com/read/29121583/a-case-report-of-gastric-lymphocytic-phlebitis-a-rare-mimic-for-malignancy
#15
Daniel L Chan, Praveen Ravindran, Dorothy Chua, Jason D Smith, King S Wong, Michael A Ghusn
INTRODUCTION: Lymphocytic phlebitis is a benign condition characterised by inflammation of the veins and rarely affects the gastrointestinal tract. Reported cases present as acute abdomen and involve the colon or small intestine. We report the fourth case of gastric lymphocytic phlebitis in the literature. PRESENTATION OF CASE: A 74-year-old female presented with eight weeks of abdominal pain. Findings at endoscopy were suggestive of a malignant ulcer on the greater curvature of antrum, while biopsies showed chronic gastritis without malignancy...
November 2, 2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/29119277/priority-of-lymph-node-dissection-for-proximal-gastric-cancer-invading-the-greater-curvature
#16
Yukio Maezawa, Toru Aoyama, Takanobu Yamada, Kazuki Kano, Tsutomu Hayashi, Tsutomu Sato, Takashi Oshima, Yasushi Rino, Munetaka Masuda, Takashi Ogata, Haruhiko Cho, Takaki Yoshikawa
BACKGROUND: The therapeutic efficacy of dissection of the splenic hilar lymph nodes (#10) has not been fully evaluated in locally advanced proximal gastric cancer (LAGC) invading the greater curvature of the stomach. METHODS: Patients with LAGC invading the greater curvature who underwent D2 total gastrectomy with splenectomy between January 2000 and May 2015 were retrospectively examined. The therapeutic value index was calculated by multiplying the metastatic rate of a station and the 5-year survival of patients with metastasis to that station; the metastatic rate and the index of each lymph node station were then compared...
November 8, 2017: Gastric Cancer
https://www.readbyqxmd.com/read/29115925/synchronous-occurrence-of-hereditary-gastric-adenocarcinoma-gastrointestinal-stromal-tumor-and-esophageal-small-cell-and-squamous-carcinoma-in-situ-an-extremely-rare-case-report
#17
Huijie Fan, Pei Lu, Li Xu, Yanru Qin, Jing Li
BACKGROUND: Hereditary diffuse gastric carcinoma (HDGC) accounts for 1-3% of all gastric carcinomas. Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal tumors in the gastrointestinal (GI) tract but they comprise fewer than 1% of all GI malignancies. Small-cell carcinoma (SmCC) is a rare histological type of esophageal carcinoma, accounting for 0.4% to 2.8% of all esophageal tumors. Co-occurrence of SmCC with esophageal tumors caused by squamous carcinoma is also very uncommon...
November 7, 2017: BMC Cancer
https://www.readbyqxmd.com/read/29115543/the-screening-and-analysis-of-protein-signatures-and-signaling-associated-with-chemoresistance-based-on-protein-pathway-array-technology-in-gastric-cancer
#18
Guodong Lian, Leping Li, Fei Ye, Daguang Wang, Jinglei Liu, Yulong Shi, Changqing Jing, Jian Suo, David Y Zhang, Man Chen
The present study was aimed to identify proteins associated with signaling pathways involved in chemoresistance, and establish a predictive model for chemoresistance in gastric cancer patients after radical surgery. A total of 140 clinically-staged III gastric cancer samples from patients after D2 radical gastrectomy were enrolled in the present study. Protein Pathway Array (PPA) and 286 antibodies were used to assess the protein expression in tumor tissues of patients. The Significance Analysis of Microarray (SAM) software and clustering and discriminant analysis were used to identify differentially expressed proteins between chemosensitive and chemoresistant subsets, and a predictive model for chemoresistance was established using the independent predictive factors...
November 6, 2017: Oncology Reports
https://www.readbyqxmd.com/read/29113410/a-risk-prediction-system-of-postoperative-hemorrhage-following-laparoscopy-assisted-radical-gastrectomy-with-d2-lymphadenectomy-for-primary-gastric-cancer
#19
Xin-Sheng Xie, Jian-Xian Lin, Ping Li, Jian-Wei Xie, Jia-Bin Wang, Jun Lu, Qi-Yue Chen, Long-Long Cao, Mi Lin, Ru-Hong Tu, Chang-Ming Huang, Chao-Hui Zheng
Objectives: To investigate risk factors of postoperative hemorrhage (PH) following laparoscopy-assisted radical gastrectomy (LARG) with D2 lymphadenectomy for primary gastric cancer (PGC) and to use those risk factors to develop a scoring system for risk assessment. Materials and Methods: A total of 1789 PGC patients were enrolled in our study. We analyzed the risk factors of PH and constructed a scoring system using 75% of the cases as the experimental group and 25% of the cases as a verification group to demonstrate the effectiveness...
October 6, 2017: Oncotarget
https://www.readbyqxmd.com/read/29102948/five-year-survival-after-surgical-removal-and-gamma-knife-stereotactic-radiosurgery-for-a-cerebellar-metastasis-from-an-esophagogastric-junction-cancer-a-case-report-and-literature-review
#20
Yoshikazu Kanazawa, Itsuo Fujita, Daisuke Kakinuma, Yuto Aoki, Hitoshi Kanno, Hiroki Arai, Kunihiko Matsuno, Tomohiro Shimoda, Takeshi Matsutani, Nobutoshi Hagiwara, Tsutomu Nomura, Takeshi Yamada, Shunji Kato, Zenya Naito, Hideaki Takasaki, Eiji Uchida
Brain metastases originating from esophageal or gastric cancer are rare, accounting for 2.1-3.3% of all brain tumors registered in Japan. There are no established therapeutic measures for brain metastases, which accordingly have a poor prognosis. We present here a patient who survived for 5 years after surgery and gamma knife treatment of a cerebellar metastasis from esophagogastric adenocarcinoma. The primary gastric cancer was treated by laparotomy with total gastrectomy, splenectomy, and D2 lymphadenectomy...
November 2017: In Vivo
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