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JOURNAL ARTICLE
Yukinori Yamagata, Takaki Yoshikawa, Ryota Sakon, Kenichi Ishizu, Takeyuki Wada, Tsutomu Hayashi
BACKGROUND: Total gastrectomy with D2 dissection including splenectomy (TGS) is usually selected for locally resectable scirrhous gastric cancer (SGC), which was established in the era of surgery alone. However, it remains unclear whether TGS for SGC is justified in the era of effective adjuvant chemotherapy. METHODS: This study included 112 SGC patients, consisting of 60 cases treated between January 2000 and December 2006 (Former group), and 52 cases treated between January 2007 and December 2016 (Latter group)...
April 18, 2024: Journal of Gastrointestinal Cancer
#2
JOURNAL ARTICLE
T Jagric, G Hladnik, R Kolaric, I Arpad, M Horvat, S Potrc
BACKGROUND: We performed a propensity score matched study comparing patients' short- and long-term results after laparoscopic omentum-preserving gastrectomy and open surgery with omentectomy with UICC stages 0-IV. METHODS: Between 2015 and 2022, 311 patients with gastric cancer underwent surgery at the University Clinical Centre Maribor. Of these, 249 met the inclusion criteria and 198 were included in the study group after PSM. RESULTS: Patients in both groups were well-balanced in demographic and pathological characteristics after PSM...
April 15, 2024: Surgical Endoscopy
#3
JOURNAL ARTICLE
Zhenyu Chen, Guangyu Chen, Yan Li, Sha Kou, Tao Wang, Lin Zhang, Yongkuan Cao, Liye Liu
PURPOSE: Neoadjuvant chemotherapy is strongly recommended for advanced gastric cancer due to good local control and a high rate of R0 dissection with this strategy. Minimally invasive techniques such as laparoscopy-assisted or total laparoscopic approaches is becoming more and more acceptable in the treatment for gastric cancer. However, the safety and efficiency of total laparoscopic D2 gastrectomy (TLG) for advanced gastric cancer after neoadjuvant chemotherapy have not been well evaluated...
April 2024: Annals of Surgical Treatment and Research
#4
JOURNAL ARTICLE
Yingsong Zheng, Yubo Ma, Chuhong Pang, KaiLai Yin, Kang Liu, Jinxia Chen, Mengli Zi, Yizhou Wei, Xiangdong Cheng, Li Yuan
BACKGROUND: Adjuvant chemotherapy (CT) constitutes the primary approach for treating resectable advanced gastric cancer (GC). However, the effectiveness of postoperative CT can differ across various patient groups. This retrospective study aimed to examine how variances in clinical and pathologic factors affect postoperative CT. METHODS: This study enrolled 2060 patients with GC who underwent curative gastrectomy at Zhejiang Cancer Hospital between January 2008 and December 2017, with 1277 receiving postoperative CT...
April 2024: Journal of Gastrointestinal Surgery
#5
JOURNAL ARTICLE
Hao Guo, WeiFeng Sun, HaiTao Duan, Chi Zhang, MaoHua Wei, Pin Liang, Xiang Hu, Liang Cao
BACKGROUND: To investigate the short-term and long-term outcomes of preserving the celiac branch of the vagus nerve during laparoscopic distal gastrectomy. METHODS: A total of 149 patients with prospective diagnosis of gastric cancer who underwent laparoscopic-assisted distal gastrectomy (LADG) combined with Billroth-II anastomosis and D2 lymph node dissection between 2017 and 2018 were retrospectively analyzed. The patients were divided into the preserved LADG group (P-LADG, n = 56) and the resected LADG group (R-LADG, n = 93) according to whether the vagus nerve celiac branch was preserved...
April 6, 2024: World Journal of Surgical Oncology
#6
JOURNAL ARTICLE
Brendha Cação Coimbra, Marina Alessandra Pereira, Leonardo Cardili, Venancio Avancini Ferreira Alves, Evandro Sobroza de Mello, Ulysses Ribeiro, Marcus Fernando Kodama Pertille Ramos
BACKGROUND: Anti-programmed death-1/programmed death-ligand 1 (PD-1/PD-L1) immunotherapy has demonstrated promising results on gastric cancer (GC). However, PD-L1 can express differently between metastatic sites and primary tumors (PT). AIM: To compare PD-L1 status in PT and matched lymph node metastases (LNM) of GC patients and to determine the correlation between the PD-L1 status and clinicopathological characteristics. METHODS: We retrospectively reviewed 284 GC patients who underwent D2-gastrectomy...
March 15, 2024: World Journal of Gastrointestinal Oncology
#7
JOURNAL ARTICLE
Sin Hye Park, Mira Han, Hong Man Yoon, Keun Won Ryu, Young-Woo Kim, Bang Wool Eom
PURPOSE: The study aimed to investigate real-world surgical outcomes of minimally invasive surgery (MIS) for advanced gastric cancer using Korean Gastric Cancer Association (KGCA)-led nationwide data. MATERIALS AND METHODS: A nationwide survey of patients who underwent surgical treatment for gastric cancer in 2019 was conducted by the KGCA. A total of 14,076 patients from 68 institutions underwent surgery, and 4,953 patients diagnosed with pathological stages IB-III gastric cancer were included...
April 2024: Journal of Gastric Cancer
#8
JOURNAL ARTICLE
Marta Lapo Pais, Joana Crisóstomo, Antero Abrunhosa, Miguel Castelo-Branco
INTRODUCTION: Bariatric surgery (BS) is the treatment of choice for refractory obesity. Although weight loss (WL) reduces the prevalence of obesity-related comorbidities, not all patients maintain it. It has been suggested that central mechanisms involving dopamine receptors may play a role in successful WL. This protocol describes an observational cross-sectional study to test if the binding of central dopamine receptors is similar in individuals who responded successfully to BS and age- and gender-matched normal-weight healthy individuals (controls)...
April 2, 2024: BMJ Open
#9
JOURNAL ARTICLE
Ufuk Karabacak, Murat Can Mollaoglu, Turan Eray Seven, Kursat Karadayi
Development of gastric cancer following bariatric surgery is very rare. Nearly all patients with cancer after mini gastric bypass/one anastomosis gastric bypass have carcinoma in their remnant stomach. This is the first case with the development of gastric cancer in the gastric pouch following mini gastric bypass surgery. Our case was a 32-year-old woman who was admitted to our department with oral intolerance 5 years after mini gastric bypass. In her endoscopic examination, an ulcerovegetan mass in the gastric pouch (Siewert type III) was detected...
January 1, 2024: Journal of Cancer Research and Therapeutics
#10
Sarmista Roy, Sushanto Neogi, Anubhuti Chaturvedi, Reena Tomar
This is the case of a 52-year-old Indian lady who presented with hematemesis, severe anemia, and an abdominal lump in cardiac failure. On radiographic evaluation, the lesion appeared to be gross circumferential asymmetric proximal gastric wall thickening, with suspicion of gastric lymphoma or tubercular hypertrophic gastritis. After stabilization with multiple transfusions, she underwent proximal D2 gastrectomy with esophago-gastric anastomosis and a total splenectomy. Grossly, the gastric rugae appeared to be hypertrophied and firm...
February 2024: Curēus
#11
JOURNAL ARTICLE
Y H Tang, Z N Huang, Q Y Chen, P Li, J W Xie, J B Wang, J X Lin, J Lu, L L Cao, M Lin, R H Tu, C H Zheng, C M Huang
Objective: To investigate the risk factors and prognostic value of the textbook outcome (TO) in patients with advanced gastric cancer (AGC) who underwent neoadjuvant chemotherapy followed by surgical resection. Methods: This is a retrospective cohort study. A total of 253 patients with AGC who underwent neoadjuvant chemotherapy combined with gastrectomy and D2 lymphadenectomy in the Department of Gastric Surgery, Fujian Medical University Union Hospital from January 2010 to December 2019 were retrospectively included...
March 27, 2024: Zhonghua Wai Ke za Zhi [Chinese Journal of Surgery]
#12
JOURNAL ARTICLE
Zhoukai Zhao, Ruopeng Zhang, Guoming Chen, Man Nie, Feiyang Zhang, Xiaojiang Chen, Jun Lin, Zewei Chen, Feizhi Lin, Chengzhi Wei, Ziqi Zheng, Shenghang Ruan, Bowen Huang, Yingbo Chen, Runcong Nie
IMPORTANCE: Whether anti-Helicobacter pylori treatment can provide survival benefits for patients with gastric cancer who are diagnosed with H pylori infection is an area with limited research. OBJECTIVE: To explore the potential survival benefits of anti-H pylori treatment after radical gastrectomy in patients with gastric cancer and presurgical confirmation of H pylori infection. DESIGN, SETTING, AND PARTICIPANTS: This retrospective cohort study was conducted using data from patients with gastric cancer treated between January 1, 2010, and December 31, 2018, and followed up for outcome ascertainment until May 19, 2021...
March 4, 2024: JAMA Network Open
#13
JOURNAL ARTICLE
Masaki Kitazono, Makoto Fujita, Shuichiro Uchiyama, Mayumi Eguchi, Naotaka Ikeda
BACKGROUND: Although robotic surgery is becoming more widespread worldwide, it is still in its infancy. This study aimed to confirm the safety and feasibility of the induction of robotic-assisted gastric surgery at a local hospital. METHODS: For five years, between 2016 and 2020, 42 laparoscopic and 71 robotic distal gastrectomies were performed at the same institution. Patients diagnosed with gastric cancer were retrieved from the database. Propensity score matching was performed based on covariates such as Age, Sex, BMI, the American Society of Anesthesiologists Physical Status, Tumor Location, pT, and pN...
March 26, 2024: Asian Journal of Surgery
#14
JOURNAL ARTICLE
Cas de Jongh, Miriam P van der Meulen, Emma C Gertsen, Hylke J F Brenkman, Johanna W van Sandick, Mark I van Berge Henegouwen, Suzanne S Gisbertz, Misha D P Luyer, Grard A P Nieuwenhuijzen, Jan J B van Lanschot, Sjoerd M Lagarde, Bas P L Wijnhoven, Wobbe O de Steur, Henk H Hartgrink, Jan H M B Stoot, Karel W E Hulsewe, Ernst Jan Spillenaar Bilgen, Marc J van Det, Ewout A Kouwenhoven, Freek Daams, Donald L van der Peet, Nicole C T van Grieken, Joos Heisterkamp, Boudewijn van Etten, Jan-Willem van den Berg, Jean-Pierre Pierie, Hasan H Eker, Annemieke Y Thijssen, Eric J T Belt, Peter van Duijvendijk, Eelco Wassenaar, Kevin P Wevers, Lieke Hol, Frank J Wessels, Nadia Haj Mohammad, Geert W J Frederix, Richard van Hillegersberg, Peter D Siersema, Erik Vegt, Jelle P Ruurda
BACKGROUND: Unnecessary D2-gastrectomy and associated costs can be prevented after detecting non-curable gastric cancer, but impact of staging on treatment costs is unclear. This study determined the cost impact of 18 F-fluorodeoxyglucose positron emission tomography/computed tomography (18F FDG-PET/CT) and staging laparoscopy (SL) in gastric cancer staging. MATERIALS AND METHODS: In this cost analysis, four staging strategies were modeled in a decision tree: (1) 18F FDG-PET/CT first, then SL, (2) SL only, (3) 18F FDG-PET/CT only, and (4) neither SL nor 18F FDG-PET/CT...
March 25, 2024: Annals of Surgical Oncology
#15
JOURNAL ARTICLE
Yosuke Egami, Keijiro Sugimura, Shinsuke Katsuyama, Toru Masuzawa, Kiminori Yanagisawa, Mitsuru Kinoshita, Ryo Ikeshima, Go Shinke, Masayuki Hiraki, Yoshiaki Ohmura, Taishi Hata, Yutaka Takeda, Kohei Murata
We report a case in which a patient with advanced gastric cancer with liver metastasis and bulky N showed marked tumor shrinkage with chemotherapy, and underwent conversion surgery. A 77-year-old male. Patient was referred to our department because of advanced gastric cancer. Upper gastrointestinal endoscopy revealed type 2 advanced cancer in the posterior wall of the gastric antrum. Abdominal CT showed thickening of the gastric wall in the same region and bulky lymph node enlargement and para-aortic lymphadenopathy behind the stomach...
March 2024: Gan to Kagaku Ryoho. Cancer & Chemotherapy
#16
JOURNAL ARTICLE
Shinsuke Katsuyama, Toru Masuzawa, Keijiro Sugimura, Kiminori Yanagisawa, Go Shinke, Mitsuru Kinoshita, Ryo Ikeshima, Masayuki Hiraki, Yoshiaki Ohmura, Taishi Hata, Yutaka Takeda, Kohei Murata
A 73-year-old man underwent upper gastrointestinal endoscopy during a medical check-up that revealed a Type 2 lesion in the anterior wall of the gastric body. The biopsy confirmed tub2. A contrast-enhanced CT scan revealed focal wall thickening and lymphadenopathy in the gastric body. The patient was diagnosed with gastric cancer(M, ante, Type 2, T4aN1M0, Stage ⅢA). Laparotomy total gastrectomy D2 dissection and Roux-en-Y reconstruction were performed. Pathological results were tub1, int, INF b, ly0, v1, pT4aN0M0, pStage ⅡB...
March 2024: Gan to Kagaku Ryoho. Cancer & Chemotherapy
#17
REVIEW
Hyung-Don Kim, Min-Hee Ryu, Yoon-Koo Kang
Standard adjuvant treatment for locally advanced gastric cancer (LAGC) is regionally different. Whereas perioperative chemotherapy is the standard in Western populations, D2 gastrectomy followed by adjuvant chemotherapy has been the standard in East Asia. Recently, the pivotal phase 3 PRODIGY and RESOLVE studies have demonstrated survival benefits of adding neoadjuvant chemotherapy to surgery followed by adjuvant chemotherapy over up-front surgery followed by adjuvant chemotherapy in Asian patients. Based on these results, neoadjuvant chemotherapy is considered one of the viable options for patients with LAGC...
March 15, 2024: Gastric Cancer
#18
JOURNAL ARTICLE
Yanghui Cao, Jiachen Zhang, Zhenyu Li, Xijie Zhang, Changzheng Li, Xin Zhang, Sen Li, Rodrigo Nascimento Pinheiro, Pengfei Ma, Junli Zhang, Chenyu Liu, Yuzhou Zhao
BACKGROUND: For patients who need laparoscopic radical gastrectomy, lymph node dissection (LND) and optimization of surgical procedures are particularly important. This study introduces the "quadrant-sandwich" method in clockwise modular D2 LND and evaluates the advantages and safety of this method. METHODS: The clinical data of 108 laparoscopic total gastrectomy patients admitted to the Affiliated Cancer Hospital of Zhengzhou University from January 2019 to January 2022 were retrospectively analyzed...
February 29, 2024: Journal of Gastrointestinal Oncology
#19
JOURNAL ARTICLE
Teruki Sakoh, Kojiro Eto, Shiro Iwagami, Naoya Yoshida, Keisuke Kosumi, Masaaki Iwatsuki, Yoshifumi Baba, Yuji Miyamoto, Daiki Yoshii, Hideo Baba
Although patients with stage IV gastric cancer who respond well to systemic chemotherapy can be treated with gastrectomy, the prognosis of patients with multiple liver metastases is poor. We herein describe a patient with stage IV gastric cancer with multiple liver metastases who underwent conversion surgery after systemic treatment with S-1 plus oxaliplatin. The patient was a 62-year-old man. Upper gastrointestinal endoscopy revealed a 30-mm type 2 tumor in the greater curvature of the stomach at the anterior wall, and biopsy revealed a poorly differentiated adenocarcinoma...
March 11, 2024: Clinical Journal of Gastroenterology
#20
JOURNAL ARTICLE
Zhichao Jiang, Yibin Xie, Wen Zhang, Chunxia Du, Yuxin Zhong, Yuelu Zhu, Liming Jiang, Lizhou Dou, Kang Shao, Yongkun Sun, Qi Xue, Yantao Tian, Shugeng Gao, Dongbing Zhao, Aiping Zhou
BACKGROUND: It remains unclear whether addition of docetaxel to the combination of a platinum and fluoropyrimidine could provide more clinical benefits than doublet chemotherapies in the perioperative treatment for locally advanced gastric/gastro-esophageal junction (LAG/GEJ) cancer in Asia. In this randomized, phase 2 study, we assessed the efficacy and safety of perioperative docetaxel plus oxaliplatin and S-1 (DOS) versus oxaliplatin plus S-1 (SOX) in LAG/GEJ adenocarcinoma patients...
March 8, 2024: Gastric Cancer
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