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https://www.readbyqxmd.com/read/27875094/laparoscopic-radical-gastrectomy-for-resectable-advanced-gastric-cancer-within-enhanced-recovery-programs-a-prospective-randomized-controlled-trial
#1
Xia Mingjie, Zhang Luyao, Tang Ze, Zhao YinQuan, Wang Quan
BACKGROUND: Enhanced recovery programs have become an important focus of perioperative management. A few studies have demonstrated the efficacy of an enhanced recovery after surgery (ERAS, which includes optimized pain control, restricted I.V. fluids, early initiation of postoperative oral feeding, and enforced mobilization) protocol in patients undergoing radical gastrectomy. We investigated the feasibility and safety of laparoscopic radical gastrectomy within ERAS programs. METHODS: In this single-center prospective randomized controlled trial conducted between September 2013 and August 2014, 149 consecutive locally advanced gastric cancer patients (T2-4, any N, M0) diagnosed by the CT scanning were allocated to either ERAS group (N = 73) or conventional pathway group (N = 76)...
November 22, 2016: Journal of Laparoendoscopic & Advanced Surgical Techniques. Part A
https://www.readbyqxmd.com/read/27837525/a-case-report-of-curative-distal-gastrectomy-for-stage-iv-gastric-cancer-after-chemoradiotherapy-in-a-patient-with-a-gastrojejunal-gastric-bypass
#2
Masataka Shimonosono, Sumiya Ishigami, Takaaki Arigami, Yoshikazu Uenosono, Yasuto Uchikado, Yoshiaki Kita, Yuko Kijima, Hiroshi Kurahara, Yuko Mataki, Kosei Maemura, Shoji Natsugoe
BACKGROUND: Advanced gastric cancer in the lower third of the stomach often results in stricture of the gastric cavity and digestive symptoms. Gastrojejunostomy has been suggested to improve such symptoms, and the advent of new anticancer agents for gastric cancer has improved the response rate of the disease, which makes it possible to perform R0 gastrectomy in part of patients with stage IV gastric cancer. We experienced a rare case in which a patient with stage IV gastric cancer and cancerous pyloric stenosis was treated with R0 surgery after undergoing a gastrojejunal bypass procedure and multidisciplinary treatment...
December 2016: Surgical Case Reports
https://www.readbyqxmd.com/read/27790867/adjuvant-treatment-combining-cellular-immunotherapy-with-chemotherapy-improves-the-clinical-outcome-of-patients-with-stage-ii-iii-gastric-cancer
#3
Yizhuo Wang, Chang Wang, Huijie Xiao, Chao Niu, Haitao Wu, Haofan Jin, Cheng Yao, Hua He, Huimin Tian, Fujun Han, Dan Li, Wei Han, Jianting Xu, Jingtao Chen, Jiuwei Cui, Wei Li
Postsurgical relapse remains a common issue for resectable gastric cancer (GC). Here, we investigated the efficacy and safety of an adjuvant treatment combining chemotherapy with cellular immunotherapy (CIT) using autologous natural killer cells, γδT cells, and cytokine-induced killer cells in the treatment of stage II/III GC. A pilot prospective cohort study was conducted in 169 patients with stage II/III GC who had undergone gastrectomy with D2 lymph node dissection. Patients were assigned into two groups according to the patient choice of treatment, including chemotherapy alone (chemo) or chemotherapy combined with CIT (chemo/CIT)...
October 27, 2016: Cancer Medicine
https://www.readbyqxmd.com/read/27789777/does-a-higher-cutoff-value-of-lymph-node-retrieval-substantially-improve-survival-in-patients-with-advanced-gastric-cancer-time-to-embrace-a-new-digit
#4
Yu-Yin Liu, Wen-Liang Fang, Frank Wang, Jun-Te Hsu, Chun-Yi Tsai, Keng-Hao Liu, Chun-Nan Yeh, Tse-Ching Chen, Ren-Chin Wu, Cheng-Tang Chiu, Ta-Sen Yeh
BACKGROUND: The present study assessed the impact of the retrieval of >25 lymph nodes (LNs) on the survival outcome of patients with advanced gastric cancer after curative-intent gastrectomy. PATIENTS AND METHODS: A total of 5,386 patients who had undergone curative gastrectomy for gastric cancer from 1994 to 2011 were enrolled. The clinicopathological parameters and overall survival (OS) were analyzed according to the number of LNs examined (≤15, n = 916; 16-25, n = 1,458; and >25, n = 3,012)...
October 27, 2016: Oncologist
https://www.readbyqxmd.com/read/27781243/-application-of-en-bloc-mesogastric-excision-in-the-treatment-of-advanced-gastric-cancer
#5
Fujian Ji, Xuedong Fang, Junnan Jiang, Yuanyu Wu, Ye Feng, Huiling Guo
OBJECTIVE: To evaluate the value of en-bloc mesogastric excision (EME) in the treatment of advanced gastric cancer. METHODS: A retrospective analysis on clinical data of 98 gastric cancer patients who underwent total gastrectomy in China-Japan Union Hospital of Jilin University from January 2013 to December 2015 was carried out, including EME group of 48 cases (according to the mesangial space) and D2 radical group of 50 cases(D2 lymphadenectomy according to the vascular markers)...
October 25, 2016: Zhonghua Wei Chang Wai Ke za Zhi, Chinese Journal of Gastrointestinal Surgery
https://www.readbyqxmd.com/read/27780937/cxc-chemokine-receptor-1-predicts-postoperative-prognosis-and-chemotherapeutic-benefits-for-tnm-ii-and-iii-resectable-gastric-cancer-patients
#6
Yifan Cao, Hao Liu, Heng Zhang, Chao Lin, Ruochen Li, Songyang Wu, He Li, Hongyong He, Weijuan Zhang, Jiejie Xu
: Backround: Abnormal expression of CXC chemokine receptor 1 (CXCR1) has shown the ability to promote tumor angiogensis, invasion and metastasis in several cancers. The purpose of our curret study is to discover the clinical prognostic significance of CXCR1 in resectable gastric cancer. METHODS: 330 gastric cancer patients who underwent R0 gastrectomy with standard D2 lymphadenectomy at Zhongshan Hospital, Fudan University between 2007 and 2008 were enrolled. CXCR1 expression was evaluated with use of immunohistochemical staining...
October 21, 2016: Oncotarget
https://www.readbyqxmd.com/read/27760962/-a-case-of-long-term-survival-after-gastrectomy-and-metachronous-brain-metastasis
#7
Yukio Maezawa, Tsutomu Sato, Kazuki Kano, Kenki Segami, Tetsushi Nakajima, Taiichi Kawabe, Junya Shirai, Hiroto Fujikawa, Toru Aoyama, Tsutomu Hayashi, Kousuke Ikeda, Takanobu Yamada, Satoshi Tsuchida, Naoto Yamamoto, Takashi Ohshima, Yasushi Rino, Munetaka Masuda, Takashi Ogata, Haruhiko Cho, Takaki Yoshikawa
A30 -year-old woman underwent total gastrectomy with D2 lymph node dissection after being diagnosed with clinical T3, N2, M0, Stage III B gastric cancer. The postoperative pathological findings revealed a T3(SE), N2, M0, Stage III B tumor. Headache, dizziness, and vomiting occurred during chemotherapy for peritoneal recurrence, using weekly paclitaxel on days 1, 8, and 15. Head CT showed a solitary tumor with a diameter of 28mm in the cerebellum, as well as cerebellar swelling and hydrocephalus. She underwent an emergency craniotomy and tumor enucleation...
October 2016: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/27760941/-a-case-of-long-term-survival-after-combination-therapy-for-gastric-cancer-with-synchronous-multiple-liver-metastasis
#8
Satoshi Kiyota, Yumi Matsuda, Syoji Hanada, Masahiko Kinoshita, Satoshi Nishizawa, Genichi Kanazawa, Hiromu Tanaka
A 63-year-old man was admitted to our hospital owing to weight loss and vertigo. Endoscopic examination revealed advanced gastric cancer type 2. Abdominal CT showed a 62mm liver tumor in segment 4 and a 26mm tumor in segment 8. Distal gastrectomy and D2 lymph node dissection were performed. After surgery, he was administered chemotherapy with S- 1. After 2 courses of treatment, the tumors' in segments 4 and 8 were reduced to 52mm and 16mm, respectively. No other metastases were detected. Left lobectomy and partial resection of segment 8 were performed...
October 2016: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/27760940/-a-case-of-her2-positive-advanced-gastric-cancer-with-multiple-liver-metastases-effectively-treated-with-trastuzumab-capecitabine-and-cisplatin-combination-therapy
#9
Yoshio Kuga, Shosuke Kitamura, Hideharu Okanobu, Hideto Sakimoto, Toshihiro Nishida
We reported a case of human epidermal growth factor receptor 2(HER2)-positive advanced gastric cancer with multiple liver metastases that responded well to a combination of trastuzumab, capecitabine, and cisplatin(T-XP therapy)as first-line chemotherapy. A 73-year-old man was admitted to our hospital in December 2012 for liver dysfunction. Based on computed tomography(CT)and gastroendoscopy findings, he was diagnosed with advanced gastric cancer with multiple liver metastases. Because HER2 protein overexpression was observed in the primary tumor, he was treated with T-XP therapy...
October 2016: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/27760939/-remarkable-response-to-trastuzumab-observed-in-a-case-of-gastric-cancer-with-her2-negative-conversion
#10
Nobutoshi Horii, Daisuke Morioka, Kazuya Yamaguchi, Yoshiki Sato
A 64-year-old woman was diagnosed with advanced gastric cancer with solitary liver metastasis. Although the HER2 status of the tumor was IHC2+, no further examination for HER2 status using FISH was performed. Four courses of S-1 and cisplatin chemotherapy were administered. The primary lesion and metastatic lesion were confirmed to have partially regressed. After 4 courses of chemotherapy, an open total gastrectomy, D2 dissection, pancreatosplenectomy, and posterior segmental hepatectomy were performed. Her postoperative course was uneventful...
October 2016: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/27760932/-neoadjuvant-chemotherapy-for-gastric-cancer
#11
Takaki Yoshikawa, Tsutomu Sato, Takanobu Yamada, Toru Aoyama, Takashi Ogata, Haruhiko Cho
Adjuvant chemotherapy aims to eradicate residual micro-metastatic tumor cells existing at distant sites outside the surgical field. The current standard adjuvant chemotherapy is S-1 for 1 year or capecitabine plus oxaliplatin for 6 months after D2 gastrectomy. However, there are some rooms in the overall survival of Stage III. Neoadjuvant chemotherapy(NAC)is a promising approach that combines intensive chemotherapy with high compliance; however, it is under development in Japan. Two JCOG phase II trials suggested that NAC was effective for bulky nodal disease...
October 2016: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/27747472/advances-in-laparoscopic-and-robotic-gastrectomy-for-gastric-cancer
#12
Sheng-Han Tsai, Chien-An Liu, Kuo-Hung Huang, Yuan-Tzu Lan, Ming-Huang Chen, Yee Chao, Su-Shun Lo, Anna Fen-Yau Li, Chew-Wun Wu, Shih-Hwa Chiou, Muh-Hwa Yang, Yi-Ming Shyr, Wen-Liang Fang
Robot-assisted gastrectomy has been reported to be a safe alternative to both conventional laparoscopy and the open approach for treating early gastric carcinoma. Currently, there are a limited number of published reports on this technique in the literature. We assessed the current status of robotic and laparoscopic surgery in the treatment of gastric cancer and compared the operative outcomes, learning curves, and oncological outcome of the two approaches. Robotic gastrectomy offers benefits that include increased ease of performing D2 lymph node dissection and reduced blood loss compared with laparoscopic gastrectomy...
October 17, 2016: Pathology Oncology Research: POR
https://www.readbyqxmd.com/read/27734274/usefulness-of-preoperative-estimated-glomerular-filtration-rate-to-predict-complications-after-curative-gastrectomy-in-patients-with-clinical-t2-4-gastric-cancer
#13
Yuri Tanaka, Mitsuro Kanda, Chie Tanaka, Daisuke Kobayashi, Akira Mizuno, Naoki Iwata, Masamichi Hayashi, Yukiko Niwa, Hideki Takami, Suguru Yamada, Tsutomu Fujii, Goro Nakayama, Hiroyuki Sugimoto, Michitaka Fujiwara, Yasuhiro Kodera
BACKGROUND: Gastrectomy with systemic lymphadenectomy is the standard of care for resectable gastric cancer (GC), but it is sometimes associated with postoperative morbidity. Predicting complications is therefore an essential part of risk management in clinical practice. The renal function is routinely evaluated before surgery by blood examinations to determine dose of medication and infusion. However, the value of various parameters of renal function in prediction of postoperative complications remain unclear...
October 12, 2016: Gastric Cancer
https://www.readbyqxmd.com/read/27721255/application-value-of-sentinel-lymph-node-biopsy-in-the-radical-operation-for-stage-ii-advanced-gastric-cancer
#14
Yongzheng Xie, Fangjun Li, Xuequn Ren
OBJECTIVE: This study aims to explore the application value of sentinel lymph node (SLN) biopsy in patients with Stage II advanced gastric cancer and its effects on prognosis. MATERIALS AND METHODS: A total of 43 patients with Stage II gastric cancer (experimental group) admitted to our department from March 2011 to February 2013 underwent radical operation using SLN biopsy, and 51 patients with gastric cancer D2 (the control group) received conventional radical operation...
October 2016: Journal of Cancer Research and Therapeutics
https://www.readbyqxmd.com/read/27700178/uncut-esophagojejunostomy-with-double-jejunal-pouch-an-alternative-reconstruction-method-that-improves-the-quality-of-life-of-patients-after-total-gastrectomy
#15
Jia Qing Gong, Yong Kuan Cao, Guo Hu Zhang, Pei Hong Wang, Guo De Luo
BACKGROUND: Currently, there is no optimal digestive tract reconstruction technique well recognized by scholars after total gastrectomy. In this study, a new reconstruction method, which is modified from the classic Roux-en-Y procedure, an uncut jejunal esophageal anastomosis with double jejunal pouch (UJEA-DJP) was established, and its advantages for improving the quality of life of patients who undergo total gastrectomy were analyzed. METHODS: Altogether 160 patients with gastric cancer enrolled in our center from September 2009 to March 2012 received radical D2 total gastrectomy...
October 4, 2016: Journal of Investigative Surgery: the Official Journal of the Academy of Surgical Research
https://www.readbyqxmd.com/read/27698908/factors-influencing-clinicians-choice-of-adjuvant-s-1-versus-capecitabine-plus-oxaliplatin-after-curative-gastrectomy-in-patients-with-gastric-cancer
#16
Ha Yeon Lee, In Gyu Hwang, Song-Ee Park, Moon Jin Kim, Se Hoon Park, Jung Hun Kang, Young Saing Kim, Sung Yong Oh, Young-Woong Won, Soon Il Lee, Jun Ho Ji, Kyong-Choun Chi
Purpose: Two recent randomized, phase III trials in Asia (ACTS-GC and CLASSIC) documented the survival benefit of postoperative chemotherapy after D2 lymph node dissection in patients with gastric cancer. We sought to determine what factors influenced clinicians' choices of either S-1 or capecitabine plus oxaliplatin (CAPOX) as adjuvant therapy after curative D2 gastrectomy. Materials and Methods: We retrospectively reviewed the clinicopathologic factors and adjuvant treatments for 435 patients from nine centers in Korea who were treated with either S-1 or CAPOX adjuvant chemotherapy after undergoing curative D2 gastrectomy between January 2013 and July 2014...
2016: Journal of Cancer
https://www.readbyqxmd.com/read/27692591/comment-on-lipocalin-type-prostaglandin-d2-synthase-modulates-the-beneficial-metabolic-effects-of-vertical-sleeve-gastrectomy
#17
Mohamed R Ali
No abstract text is available yet for this article.
May 12, 2016: Surgery for Obesity and related Diseases: Official Journal of the American Society for Bariatric Surgery
https://www.readbyqxmd.com/read/27651972/perforated-carcinoma-in-the-gastric-remnant-a-case-of-conservative-treatment-prior-to-successful-curative-r0-resection
#18
Ken Yuu, Hiroshi Kawashima, Sho Toyoda, Satoshi Okumura, Kansuke Yamamoto, Naoto Mizumura, Aya Ito, Hiromitsu Maehira, Atsuo Imagawa, Masao Ogawa, Masayasu Kawasaki, Masao Kameyama
An 80-year-old man who had undergone distal gastrectomy and Billroth-II gastrojejunostomy 38 years previously, for a benign gastric ulcer, was diagnosed with remnant gastric cancer based on upper gastrointestinal endoscopy findings. He presented at our emergency department with acute-onset epigastric pain due to perforated remnant gastric cancer. Conservative medical management was selected, including nasogastric tube insertion, antibiotics, and proton pump inhibitors, because his peritonitis was limited to his epigastrium and his general condition was stable...
2016: Case Reports in Surgery
https://www.readbyqxmd.com/read/27649005/prognostic-assessment-of-gastric-cancer-retrospective-analysis-of-two-decades
#19
Maria Teresa Mita, Federico Marchesi, Stefano Cecchini, Francesco Tartamella, Matteo Ricco', Hariscine Keng Abongwa, Luigi Roncoroni
BACKGROUND: Gastric cancer mortality rates have remained relatively unchanged over the past decades, in spite of progressive decrease in incidence. Nodal status represents a key factor for prognostic assessment, allowing a tailored-made adjuvant therapy for the patients. The aim of this study is to evaluate the prognostic influence of different nodal involvement indicators on the overall survival in a large series of patients submitted to gastrectomy at our Institution. METHODS: we retrospectively collected data from 634 newly diagnosed patients with gastric cancer who underwent curative gastrectomy, with D1/D2 lymphadenectomy during the last 20 years...
2016: Acta Bio-medica: Atenei Parmensis
https://www.readbyqxmd.com/read/27647967/evaluation-of-rational-extent-lymphadenectomy-for-local-advanced-gastric-cancer
#20
Han Liang, Jingyu Deng
Based upon studies from randomized clinical trials, the extended (D2) lymph node dissection is now recommended as a standard procedure for local advanced gastric cancer worldwide. However, the rational extent lymphadenectomy for local advanced gastric cancer has remained a topic of debate in the past decades. Due to the limitation of low metastatic rate in para-aortic nodes (PAN) in JCOG9501, the clinical benefit of D2+ para-aortic nodal dissection (PAND) for patients with stage T4 and/or stage N3 disease, which is very common in China and other countries except Japan and Korea, cannot be determined...
August 2016: Chinese Journal of Cancer Research, Chung-kuo Yen Cheng Yen Chiu
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