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https://www.readbyqxmd.com/read/28732676/expansion-of-lymph-node-metastasis-in-mixed-type-submucosal-invasive-gastric-cancer
#1
Koji Mikami, Yukiko Hirano, Kitaro Futami, Takafumi Maekawa
BACKGROUND/OBJECTIVE: Mixed-type early gastric cancer (differentiated and undifferentiated components) incurs a higher risk of lymph node metastasis than pure-type early gastric cancer (only differentiated or only undifferentiated components). Therefore, we investigated the expansion of lymph node metastasis in mixed-type submucosal invasive gastric cancer in order to establish the most appropriate treatment for mixed-type cancer. METHODS: We retrospectively analyzed 279 consecutive patients with submucosal invasive gastric cancer who underwent curative gastrectomy for gastric cancer between 1996 and 2015...
July 18, 2017: Asian Journal of Surgery
https://www.readbyqxmd.com/read/28722091/-analysis-of-lymph-node-metastasis-pattern-in-gastric-cancer-patients-at-stage-pn1
#2
Bin Ke, Ning Liu, Rupeng Zhang, Xiaofan Guo, Bin Li, Xuejun Wang, Han Liang
OBJECTIVE: To investigate the lymph node metastasis pattern in pN1 stage gastric cancer patients and to analyze its risk factors. METHODS: Clinicopathological data of 219 patients who underwent radical gastrectomy and were confirmed as pN1 stage gastric cancer between January 2013 and March 2016 were reviewed. All the patients underwent D2 or extended D2(D2+) lymphadenectomy. The overall metastatic rate was calculated. The risk factors associated with lymph node metastasis were analyzed...
July 25, 2017: Zhonghua Wei Chang Wai Ke za Zhi, Chinese Journal of Gastrointestinal Surgery
https://www.readbyqxmd.com/read/28722081/-quality-control-of-radical-lymphadenectomy-for-gastric-cancer
#3
Han Liang
D2 lymphadenectomy is currently the worldwide standard operation for locally advanced gastric cancer. There were no major modifications for extent of standard lymphadenectomy in Japanese gastric cancer treatment guidelines 2014(ver.4). Prophylactic para-arotic lymphadenectomy is not recommended. Although there is no high level evidence, D2+No14v may be beneficial to patients who are suspected to harbor metastasis to No6 node, and D2+No13 lymphadenectomy may be an option in a potentially curative gastrectomy for tumors invading the duodenum...
July 25, 2017: Zhonghua Wei Chang Wai Ke za Zhi, Chinese Journal of Gastrointestinal Surgery
https://www.readbyqxmd.com/read/28707042/validity-of-neoadjuvant-chemotherapy-with-docetaxel-cisplatin-and-s-1-for-resectable-locally-advanced-gastric-cancer
#4
Kinro Sasaki, Shinichi Onodera, Kichiro Otsuka, Hitoshi Satomura, Eigo Kurayama, Tsukasa Kubo, Masakazu Takahashi, Jun Ito, Masanobu Nakajima, Satoru Yamaguchi, Kazuhito Miyachi, Hiroyuki Kato
Gastrectomy with D2 lymphadenectomy plus postoperative chemotherapy is the standard treatment for resectable locally advanced gastric cancer in Japan. However, the prognosis of patients with serosa-positive tumors remains unsatisfactory because of peritoneal recurrence. This study aimed to investigate the validity of neoadjuvant therapy with docetaxel, cisplatin, and S-1 (DCS) in patients with locally advanced gastric cancer. Thirty patients with locally advanced gastric cancer underwent neoadjuvant DCS therapy at Dokkyo Medical University Hospital between June 2013 and October 2015...
August 2017: Medical Oncology
https://www.readbyqxmd.com/read/28705789/treatment-of-peritoneal-dissemination-in-stomach-cancer-patients-with-cytoreductive-surgery-and-hyperthermic-intraperitoneal-chemotherapy-hipec-rationale-and-design-of-the-periscope-study
#5
Rosa T van der Kaaij, Hidde Jw Braam, Henk Boot, Maartje Los, Annemieke Cats, Cecile Grootscholten, Jan Hm Schellens, Arend Gj Aalbers, Alwin Dr Huitema, Catherijne Aj Knibbe, Djamila Boerma, Marinus J Wiezer, Bert van Ramshorst, Johanna W van Sandick
BACKGROUND: Patients with gastric cancer and peritoneal carcinomatosis have a very poor prognosis; median survival is 3 to 4 months. Palliative systemic chemotherapy is currently the only treatment available in the Netherlands. Intraoperative hyperthermic intraperitoneal chemotherapy (HIPEC) has an established role in the treatment of peritoneal carcinomatosis originating from colorectal cancer, appendiceal cancer, and pseudomyxoma peritonei; its role in gastric cancer is uncertain. Currently, there is no consensus on the choice of chemotherapeutic agents used in HIPEC for gastric cancer...
July 13, 2017: JMIR Research Protocols
https://www.readbyqxmd.com/read/28678754/impact-of-splenic-hilar-lymph-node-metastasis-on-prognosis-in-patients-with-advanced-gastric-cancer
#6
Taeil Son, In Gyu Kwon, Joong Ho Lee, Youn Young Choi, Hyoung-Il Kim, Jae-Ho Cheong, Sung Hoon Noh, Woo Jin Hyung
BACKGROUND: Impact of splenic hilar LN dissection during total gastrectomy for proximal advanced gastric cancer is controversial. The objective of this study was to assess the impact on prognosis of splenic hilar lymph node(LN) metastasis compared to that of metastasis to other regional LN groups. STUDY DESIGN: Patients who underwent total gastrectomy with D2 LN dissection from 2000 to 2010 were reviewed retrospectively. The clinicopathologic characteristics and long-term results of patients with splenic hilar LN metastasis were compared to those of patients with only metastasis to other extraperigastric LNs (stations #8a, #9, #11, or #12a)...
June 28, 2017: Oncotarget
https://www.readbyqxmd.com/read/28678323/expression-and-prognostic-roles-of-magnesium-dependent-phosphatase-1-in-gastric-cancer
#7
Y Chen, J Lin, M Yang, C-W Xu, B-Z Chen, X-J Li, W-F Zhu, W-D Fu, H Yu, M-G Ying, G Chen
OBJECTIVE: Gastric cancer is a leading cause of cancer deaths and has a poor prognosis after diagnosis. Previous studies showed that Magnesium-Dependent Phosphatase-1 (MDP-1) might be a key component for glycosylation in human protein repair, and an alteration of its function has been involved in some aspects of cellular metabolic networks linked to either normal or pathological processe. In this study, we investigate the MDP-1 status in patients with gastric carcinoma, and determine the potential relationship between MDP-1 and clinical outcome...
June 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28677888/laparoscopic-total-gastrectomy-for-advanced-gastric-cancer-in-a-patient-with-situs-inversus-totalis
#8
Kengo Shibata, Hideki Kawamura, Nobuki Ichikawa, Kazuaki Shibuya, Tadashi Yoshida, Yosuke Ohno, Shigenori Homma, Akinobu Taketomi
Situs inversus totalis (SIT) is a rare congenital anomaly. Generally, laparoscopic surgery is difficult to perform in patients with SIT because of both the potential challenges associated with unexpected vascular anomalies and the lack of standardized strategy for handling such cases. This is the first report of laparoscopic total gastrectomy with lymph node dissection for advanced gastric cancer in a patient with SIT. A 79-year-old man with SIT was diagnosed with advanced gastric cancer. We performed laparoscopic total gastrectomy with modified D2 lymph node dissection (D2 without splenectomy) and esophagojejunal anastomosis using an overlap method involving retrocolic Roux-en-Y reconstruction...
July 5, 2017: Asian Journal of Endoscopic Surgery
https://www.readbyqxmd.com/read/28668863/phase-i-study-of-neoadjuvant-chemotherapy-with-capecitabine-and-oxaliplatin-for-locally-advanced-gastric-cancer
#9
Hironaga Satake, Masato Kondo, Motoko Mizumoto, Takeshi Kotake, Yoshihiro Okita, Takatsugu Ogata, Yukimasa Hatachi, Hisateru Yasui, Akira Miki, Yukihiro Imai, Chihiro Ichikawa, Kenta Murotani, Masahito Kotaka, Takeshi Kato, Satoshi Kaihara, Akihito Tsuji
AIM: To determine the recommended dose of neoadjuvant chemotherapy of combined capecitabine and oxalipatin (G-XELOX) for locally advanced gastric cancer. PATIENTS AND METHODS: Patients received two cycles of neoadjuvant chemotherapy with oxaliplatin on day 1 and capecitabine (2,000 mg/m(2)/day, b.i.d.) on days 1-14, repeated every 3 weeks. They then underwent gastrectomy with curative D2/3 lymph-node dissection followed by adjuvant therapy with S-1 for 1 year. De-escalation of oxaliplatin dose was planned (starting at level 1, oxalipatin 130 mg/m(2))...
July 2017: Anticancer Research
https://www.readbyqxmd.com/read/28628714/advanced-real-time-multi-display-educational-system-armes-an-innovative-real-time-audiovisual-mentoring-tool-for-complex-robotic-surgery
#10
Joong Ho Lee, Eiji Tanaka, Yanghee Woo, Güner Ali, Taeil Son, Hyoung-Il Kim, Woo Jin Hyung
INTRODUCTION: The recent scientific and technologic advances have profoundly affected the training of surgeons worldwide. We describe a novel intraoperative real-time training module, the Advanced Robotic Multi-display Educational System (ARMES). METHODS: We created a real-time training module, which can provide a standardized step by step guidance to robotic distal subtotal gastrectomy with D2 lymphadenectomy procedures, ARMES. The short video clips of 20 key steps in the standardized procedure for robotic gastrectomy were created and integrated with TilePro™ software to delivery on da Vinci Surgical Systems (Intuitive Surgical, Sunnyvale, CA)...
June 19, 2017: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28616601/minimally-invasive-surgery-for-gastric-cancer-in-brazil-current-status-and-perspectives-a-report-from-the-brazilian-laparoscopic-oncologic-gastrectomy-group-blogg
#11
REVIEW
Paulo Kassab, Wilson Luiz da Costa, Carlos Eduardo Jacob, Roberto de Moraes Cordts, Osvaldo Antônio Prado Castro, Leandro Cardoso Barchi, Ivan Cecconello, Amir Zeide Charruf, Felipe José Fernández Coimbra, Antônio Moris Cury, Alessandro Landskron Diniz, Igor Correia de Farias, Wilson Rodrigues de Freitas, André Luis de Godoy, Elias Jirjoss Ilias, Carlos Alberto Malheiros, Marcus Fernando Kodama Pertille Ramos, Heber Salvador de Castro Ribeiro, André Roncon Dias, Fábio Rodrigues Thuler, Osmar Kenji Yagi, Laércio Gomes Lourenço, Bruno Zilberstein
The minimally invasive surgery for gastric cancer in Brazil has begun about two years after the first laparoscopic gastrectomy (LG) performed by Kitano in Japan, in 1991. Although the report of first surgeries shows the year of 1993, there was no dissemination of the technique until the years 2010. At that time with the improvement of optical devices, laparoscopic instruments and with the publications coming from Asia, several Brazilian surgeons felt encouraged to go to Korea and Japan to learn the standardization of the LG...
2017: Translational Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28616599/current-status-and-future-perspectives-of-laparoscopic-radical-surgery-for-advanced-gastric-cancer
#12
REVIEW
Takahiro Kinoshita, Akio Kaito
Laparoscopic radical gastrectomy with lymph node dissection has widely penetrated to East Asian countries, where incidence of gastric cancer occurrence is higher than the rest of the world. Laparoscopic distal gastrectomy for cStageI disease is regarded as one of the option in daily practice in the latest Japanese guidelines; however its applicability to more advanced disease (Stage II/III) is still under debate. Actually, operative techniques of laparoscopic D2 dissection is being matured, but still, necessity of total omentectomy, splenic hilar dissection, management of bulky nodes or large primary tumor, high-level anastomosis in esophageal invasion cases, and extensive peritoneal lavage can be raised as technical limitations...
2017: Translational Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28584890/survival-benefit-of-d2-plus-gastrectomy-in-gastric-cancer-patients-with-duodenal-invasion
#13
Koshi Kumagai, Takeshi Sano, Naoki Hiki, Souya Nunobe, Masahiro Tsujiura, Satoshi Ida, Manabu Ohashi, Toshiharu Yamaguchi
BACKGROUND: The optimal extent of lymph node (LN) dissection for gastric cancer with duodenal invasion is yet to be clarified. This study sought to evaluate the significance of gastrectomy with D2-plus lymphadenectomy including posterior LNs along the common hepatic artery (no. 8p), hepatoduodenal ligament LNs along the bile duct (no. 12b) and those behind the portal vein (no. 12p), LNs on the posterior surface of the pancreatic head (no. 13), LNs along the superior mesenteric vein (no...
June 5, 2017: Gastric Cancer
https://www.readbyqxmd.com/read/28561675/gastric-cancer-in-asia-unique-features-and-management
#14
Tomoyuki Irino, Hiroya Takeuchi, Masanori Terashima, Toshifumi Wakai, Yuko Kitagawa
Gastric cancer (GC) poses a burden to patients across the globe as the third leading cause of cancer deaths worldwide. Incidence of GC is particularly high in Asian countries, which is attributed to the prevalence of Helicobacter pylori (H. pylori) infection and has prompted the establishment of unique treatment strategies. D2 gastrectomy, which was established in the 1950s in Japan, has served as a gold standard for locally advanced GC for over half a century. Since the beginning of the 21st century, endoscopic resection (ER) techniques and minimally invasive laparoscopic surgery have greatly changed the treatment of patients with early GC...
2017: American Society of Clinical Oncology Educational Book
https://www.readbyqxmd.com/read/28540696/negative-conversion-of-high-serum-p53-antibody-titers-in-a-patient-with-gastric-cancer-at-31%C3%A2-months-after-surgery
#15
Kenji Murayama, Tatsuki Nanami, Takashi Suzuki, Yoko Oshima, Satoshi Yajima, Tetsuo Nemoto, Hideaki Shimada
We performed distal gastrectomy with D2 lymph node dissection, pathological stage was Stage IB (T2N0M0), in a 68-year-old male with gastric adenocarcinoma. We then monitored serum p53 antibody titers for 5 years and found it consistently decreased, without disease recurrence. Although the s-p53-Ab titer remained positive even after 2 years, it decreased to 16.5, 4.45, 2.66, 1.55, and 1.18 U/ml at 3 months, 7 months, 1 year, 2 years and 3 years after surgery, respectively. The s-p53-Ab titer finally converted from positive to negative at 31 months postoperatively without any sign of recurrence by computed tomography examination at 5 years after surgery...
August 2017: Clinical Journal of Gastroenterology
https://www.readbyqxmd.com/read/28539031/-micrometastasis-in-gastric-cancer
#16
REVIEW
Gun Jung Youn, Woo Chul Chung
Although the incidence and mortality rate of gastric cancer have been steadily declining, gastric cancer is still the fourth most common cancer in the world and more than 50% of cases occur in Eastern Asia. In Korea, gastric cancer is the second most common cancer and third cause of cancer related death. The standard surgical procedure for resectable advanced gastric cancer is D2 lymphadenectomy with radical gastrectomy. Even though R0 resection was completed, recurrence is relatively common, and contributes to the limited survival of the patients in gastric cancer...
May 25, 2017: Korean Journal of Gastroenterology, Taehan Sohwagi Hakhoe Chi
https://www.readbyqxmd.com/read/28536493/postoperative-chemotherapy-with-s-1-plus-oxaliplatin-versus-s-1-alone-in-locally-advanced-gastric-cancer-rescue-gc-study-a-protocol-for-a-phase-iii-randomized-controlled-trial
#17
Xiang Hu, Lin Chen, Yian Du, Biao Fan, Zhaode Bu, Xin Wang, Yingjiang Ye, Zhongtao Zhang, Gang Xiao, Fei Li, Qingsi He, Guoli Li, Xian Shen, Bin Xiong, Liming Zhu, Jiwei Liu, Lian Liu, Tao Wu, Jing Zhou, Jun Zhang, Gang Zhao, Xulin Wang, Pin Liang, Xinxin Wang, Yan Zhang, Xiaojiang Wu, Ji Zhang, Xin Ji, Xianglong Zong, Tao Fu, Ziyu Jia, Jiafu Ji
BACKGROUND: The ACTS-GC study had shown postoperative adjuvant therapy with S-1 improved survival of patients with locally advanced gastric cancer. Addition of oxaliplatin to S-1 is considered to be acceptable as one of the treatment options for gastric cancer patients after radical gastrectomy with D2 lymph node excision. METHODS: We have commenced a randomized phase III trial in December 2016 to evaluate S-1 plus oxaliplatin compared with S-1 alone in the adjuvant setting for locally advanced gastric cancer...
April 2017: Chinese Journal of Cancer Research, Chung-kuo Yen Cheng Yen Chiu
https://www.readbyqxmd.com/read/28500392/a-case-of-advanced-gastric-cancer-achieved-a-pathological-complete-response-by-chemotherapy
#18
Kazuhiro Tada, Tsuyoshi Etoh, Yuki Shitomi, Yoshitake Ueda, Manabu Tojigamori, Hidefumi Shiroshita, Norio Shiraishi, Masafumi Inomata
BACKGROUND: Although chemotherapy is the first recommended treatment of unresectable gastric cancer, a pathological complete response is a rare event. CASE PRESENTATION: A 58-year-old male was diagnosed as gastric cancer with a bulky tumor, lymphadenopathy, and suspicious peritoneal dissemination. The patient underwent chemotherapy with S-1 and cisplatin. After three courses of chemotherapy, a computed tomography showed dramatic improvements in gastric wall thickening, shrinkage of lymphadenopathy, and disappearance of disseminated peritoneal lesion...
December 2017: Surgical Case Reports
https://www.readbyqxmd.com/read/28496008/negative-lymph-node-count-is-a-significant-prognostic-factor-in-patient-with-stage-iv-gastric-cancer-after-palliative-gastrectomy
#19
Changhua Zhuo, Mingang Ying, Ruirong Lin, Xianyi Wu, Shen Guan, Chunkang Yang
Negative lymph node (NLN) count has been validated as a protective predictor in various cancers after radical resection. However, the prognostic value of NLN count in the setting of stage IV gastric cancer patients who have received palliative resection has not been investigated. Surveillance, Epidemiology, and End Results Program (SEER)-registered gastric cancer patients were used for analysis in this study. Kaplan-Meier survival curves and multivariate Cox proportional hazards model were used to assess the risk factors for patients' survivals...
April 26, 2017: Oncotarget
https://www.readbyqxmd.com/read/28493221/radical-surgery-for-gastric-cancer-in-octogenarian-patients
#20
Francesco Casella, Andrea Sansonetti, Andrea Zanoni, Cofini Vincenza, Alberto Capodacqua, Roberto Verzaro
To valuate feasibility and results of radical surgery in octogenarian patients with gastric cancer. We collected data on 60 patients that underwent gastrectomy with an R0 resection at our Institution from 2010 to 2015. Patients were divided into two groups: octogenarian (OG) (n = 26), consisting of patients aged 80-89 years, and younger (YG) (n = 34), consisting of patients under 80 years of age. All patients were treated with total or subtotal gastrectomy with lymphadenectomy. A D2-lymphadenectomy was performed in 11 and 24 patients, a D1+ in 5 and 4, a D1 in 8 and 6, and a D0 in 2 and 0 cases in OG and YG respectively...
May 10, 2017: Updates in Surgery
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