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Lea Bayer, Jessica Gümpel, Gerd Hause, Martin Müller, Thomas Grunwald
Papillomavirus capsids are known to have the ability to package DNA plasmids and deliver them both in vitro and in vivo. Of all known papillomavirus types, human papillomaviruses (HPVs) are by far the most intensely studied. Although HPVs work well as gene transfer vectors, their use is limited as most individuals are exposed to this virus either through a HPV vaccination or natural infection. To circumvent these constraints, we produced pseudovirions (PsVs) of ten non-human papillomavirus types and tested their transduction efficiencies in vitro...
2018: PloS One
Judit Symmank, Cathrin Bayer, Christiane Schmidt, Anne Hahn, Daniel Pensold, Geraldine Zimmer
Epigenetic mechanisms of gene regulation, including DNA methylation and histone modifications, call increasing attention in the context of development and human health. Thereby, interactions between DNA methylating enzymes and histone modifications tremendously multiply the spectrum of potential regulatory functions. Epigenetic networks are critically involved in the establishment and functionality of neuronal circuits that are composed of gamma-aminobutyric acid (GABA)-positive inhibitory interneurons and excitatory principal neurons in the cerebral cortex...
June 18, 2018: Epigenetics: Official Journal of the DNA Methylation Society
HueyTyng Lee, Agnieszka A Golicz, Philipp E Bayer, Anita Severn-Ellis, Chon-Kit Kenneth Chan, Jacqueline Batley, Gary A Kendrick, David Edwards
Seagrasses are marine angiosperms that live fully submerged in the sea. They evolved from land plant ancestors, with multiple species representing at least three independent return to the sea events. This raises the question whether these marine angiosperms followed the same adaptation pathway to allow them to live and reproduce under the hostile marine conditions. To compare the basis of marine adaptation between seagrass lineages, we generated genomic data for Halophila ovalis and compared this with recently published genomes for two members of Zosteraceae, as well as genomes of five non-marine plant species (Arabidopsis thaliana, Oryza sativa, Phoenix dactylifera, Musa acuminata, and Spirodela polyrhiza)...
April 18, 2018: Journal of Experimental Botany
Franziska Trusch, Lars Loebach, Stephan Wawra, Elaine Durward, Andreas Wuensch, Nurul Aqilah Iberahim, Irene de Bruijn, Kevin MacKenzie, Ariane Willems, Aleksandra Toloczko, Javier Diéguez-Uribeondo, Tim Rasmussen, Thomas Schrader, Peter Bayer, Chris J Secombes, Pieter van West
The animal-pathogenic oomycete Saprolegnia parasitica causes serious losses in aquaculture by infecting and killing freshwater fish. Like plant-pathogenic oomycetes, S. parasitica employs similar infection structures and secretes effector proteins that translocate into host cells to manipulate the host. Here, we show that the host-targeting protein SpHtp3 enters fish cells in a pathogen-independent manner. This uptake process is guided by a gp96-like receptor and can be inhibited by supramolecular tweezers...
June 14, 2018: Nature Communications
Chengxi Wu, Carolyn L Bayer
The function of the placenta is challenging to characterize and as a result is understudied, despite the growing awareness of the impact of the placental environment on human health and development. Medical imaging has the potential to improve our ability to screen for diseases associated with placental insufficiency, and improve the monitoring and treatment of complex obstetric patients. This review provides an overview of clinical and preclinical imaging modalities currently available for assessing placental function, with an emphasis on emerging preclinical imaging modalities; as a group, these emerging modalities provide exceptional contrast and sensitivity for multimodal functional and molecular imaging of the placenta...
June 14, 2018: Physics in Medicine and Biology
Patricio Opazo, Silvia Viana da Silva, Mario Carta, Christelle Breillat, Steven J Coultrap, Dolors Grillo-Bosch, Matthieu Sainlos, Françoise Coussen, K Ulrich Bayer, Christophe Mulle, Daniel Choquet
Alzheimer's disease (AD) is emerging as a synaptopathology driven by metaplasticity. Indeed, reminiscent of metaplasticity, oligomeric forms of the amyloid-β peptide (oAβ) prevent induction of long-term potentiation (LTP) via the prior activation of GluN2B-containing NMDA receptors (NMDARs). However, the downstream Ca2+ -dependent signaling molecules that mediate aberrant metaplasticity are unknown. In this study, we show that oAβ promotes the activation of Ca2+ /calmodulin-dependent kinase II (CaMKII) via GluN2B-containing NMDARs...
June 12, 2018: Cell Reports
Oliver Dörr, Claudia Walther, Christoph Liebetrau, Till Keller, Thomas Sommer, Niklas Boeder, Matthias Bayer, Pascal Bauer, Helge Möllmann, Luise Gaede, Christian Troidl, Sandra Voss, Timm Bauer, Christian W Hamm, Holger Nef
BACKGROUND: Percutaneous mitral valve repair (PMVR) is an interventional treatment option in patients with severe mitral regurgitation (MR) who have a high risk for open-heart surgery. Currently, there is limited information about predictors of procedural success after PMVR. Galectin-3 (Gal-3) and ST2 induce fibrotic alterations in severe MR and heart failure. The aim of the present study was to examine the predictive value of Gal-3 and ST2 as specific indicators of therapeutic success in high-risk patients undergoing PMVR...
June 12, 2018: Clinical Cardiology
Alexandra Linnemann, Magdalena M Hilsenbek, Irene Lelieveld, Katharina Geschke, Dominik Wolf, Andreas Fellgiebel
Background Caregiver burden is one of the most common reasons for hospitalization of patients with dementia. However, changes of location are not recommended for patients with dementia and associated with negative outcomes for patients with dementia. As there is yet a lack of outpatient treatment options, this study explores psychiatric day clinic treatment as option for patients with dementia by comparing characteristics of voluntarily treated patients with dementia and their respective informal caregivers between an inpatient and day clinic setting...
January 1, 2018: Dementia
Seunghoon Jee, Ki Sun Song, Moon Gi Kang
Recently, several red-green-blue-white (RGBW) color filter arrays (CFAs), which include highly sensitive W pixels, have been proposed. However, RGBW CFA patterns suffer from spatial resolution degradation owing to the sensor composition having more color components than the Bayer CFA pattern. RGBW CFA demosaicing methods reconstruct resolution using the correlation between white (W) pixels and pixels of other colors, which does not improve the red-green-blue (RGB) channel sensitivity to the W channel level...
May 21, 2018: Sensors
Yoshiaki Takemoto, Mitsuhiro Tsukimura, Hideki Kato, Shunsuke Suzuki, Jun Aoki, Toru Kondo, Haruhisa Saito, Yuichi Gomi, Seisuke Matsuda, Yoshitaka Tadaki
We developed a multiband imaging CMOS image sensor (CIS) with a multi-storied photodiode structure, which comprises two photodiode (PD) arrays that capture two different images, visible red, green, and blue (RGB) and near infrared (NIR) images at the same time. The sensor enables us to capture a wide variety of multiband images which is not limited to conventional visible RGB images taken with a Bayer filter or to invisible NIR images. Its wiring layers between two PD arrays can have an optically optimized effect by modifying its material and thickness on the bottom PD array...
May 24, 2018: Sensors
Keith Dunn, Marie-Hélène Lafeuille, Xiaolong Jiao, Hela Romdhani, Bruno Emond, Kimberly Woodruff, Jacqueline Pesa, Neeta Tandon, Patrick Lefebvre
BACKGROUND: Adherence to antiretrovirals (ARVs) is critical to achieving durable virologic suppression. OBJECTIVE: To investigate risk factors of poor adherence and the effect of suboptimal adherence on health care resource utilization (HCRU) and costs in Medicaid patients. METHODS: A retrospective longitudinal study was conducted using Medicaid data. Adults (aged ≥ 18 years) with human immunodeficiency virus (HIV)-1 initiating selected ARVs (index date) were identified...
June 7, 2018: Journal of Managed Care & Specialty Pharmacy
Liang Li, Wessam Abdelhady, Niles P Donegan, Kati Seidl, Ambrose Cheung, Yu-Feng Zhou, Michael R Yeaman, Arnold S Bayer, Yan Q Xiong
Persistent MRSA bacteremia (PB) represents an important subset of S. aureus endovascular infections. In this study, we investigated potential genetic mechanisms underlying the persistent outcomes. Compared to resolving bacteremia (RB) isolates (negative blood cultures within 2-4 days of therapy), PB strains (positive blood cultures after ≥ 7 days of therapy) had significantly: i) earlier-onset activation of key virulence regulons and structural genes (e.g., sigB, sarA, sae and cap5); ii) higher expression of purine biosynthesis genes (e...
June 2, 2018: Journal of Infectious Diseases
Tengfei Guo, Haiquan Yang, Qingyou Liu, Hannian Gu, Ning Wang, Wenbin Yu, Yang Dai
Red mud (RM) is an industrial waste generated during production of alumina from using the Bayer process or the sintering process. Four types of red mud from China were characterized for their diverse chemical and mineral compositions using inductively coupled plasma-atomic emission spectroscopy (ICP-AES), inductively coupled plasma-mass spectrometry (ICP-MS) and X-ray diffraction (XRD). Acid treatment was employed to obtain activated red mud (ARM), posing increased surface areas from 10-28 m2 /g to 220-350 m2 /g...
May 2018: Water Science and Technology: a Journal of the International Association on Water Pollution Research
Stefan Clemens Meier, Albina Holz, Jan Kulenkampff, Alexei Schmidt, Daniel Kratzert, Daniel Himmel, Dominik Schmitz, Ernst-Wilhelm Scheidt, Wolfgang Scherer, Christine Bülow, Martin Timm, Rebecka Lindblad, Scott T Akin, Vincente Zamudio-Bayer, Bernd von Issendorff, Michael A Duncan, Tobias Lau, Ingo Krossing
The synthesis and structural characterization of the hitherto unknown parent Co(benzene)2+ complex and several of its homologues starting either from a Co(CO)5+ salt, or directly from Co2(CO)8 and a Ag+ salt is described. Stability and solubility of these complexes was granted by using the weakly coordinating anions [Al(ORF)4]- and [F{Al(ORF)3}2]- {RF=C(CF3)3}. Especially the weakly bound Co(ortho-difluorobenzene)2+ salts are suitable precursors for further CoI salts, e.g. the structurally characterized low-coordinate 12 valence electron Co(PtBu3)2+ and Co(NHC)2+ salts...
May 30, 2018: Angewandte Chemie
Jordana K Bayer, Amy Morgan, Luke A Prendergast, Ruth Beatson, Tamsyn Gilbertson, Lesley Bretherton, Harriet Hiscock, Ronald M Rapee
The aim of this study was to explore how some temperamentally inhibited young children and not others in the general population develop anxiety disorders and broader clinical-level internalizing (anxious/depressive) problems, with a focus on the family. A brief screening tool for inhibition was universally distributed to parents of children in their year before starting school across eight socioeconomically diverse government areas in Melbourne, Australia (307 preschool services). Screening identified 11% of all children as inhibited...
May 28, 2018: Journal of Abnormal Child Psychology
Theresa Bayer, Alokta Chakrabarti, Julien Lancelot, Tajith B Shaik, Kristin Hausmann, Jelena Melesina, Karin Schmidtkunz, Martin Marek, Frank Erdmann, Matthias Schmidt, Dina Robaa, Christophe Romier, Raymond J Pierce, Manfred Jung, Wolfgang Sippl
Schistosomiasis is a neglected parasitic disease that affects more than 265 million people worldwide and for which the control strategy relies on mass treatment with only one drug, praziquantel. Based on the 3-chlorobenzothiophene-2-hydroxamic acid J1075, a series of hydroxamic acids with different scaffolds was prepared as potential inhibitors of Schistosoma mansoni histone deacetylase 8 (SmHDAC8). The crystal structures of SmHDAC8 with four inhibitors provided insights into the binding mode and orientation of molecules in the binding pocket as well as the orientation of its flexible amino acid residues...
May 27, 2018: ChemMedChem
Nicholas J Vogelzang, Sumanta K Pal, Sameer R Ghate, Nanxin Li, Elyse Swallow, Miranda Peeples, Miriam L Zichlin, Mark K Meiselbach, Jose Ricardo Perez, Neeraj Agarwal
BACKGROUND: The median age at renal cell carcinoma (RCC) diagnosis is 64 years. However, few studies have assessed the real-world time on treatment (TOT), health resource utilization (HRU), costs, or treatment compliance associated with targeted therapy use among patients in this age group with RCC. OBJECTIVE: To assess the HRU, costs, and compliance during TOT among Medicare patients aged ≥ 65 years with advanced RCC (aRCC) who initiated first targeted therapy with pazopanib or sunitinib...
June 2018: Journal of Managed Care & Specialty Pharmacy
Janette B Myers, Vincent Zaegel, Steven J Coultrap, Adam P Miller, K Ulrich Bayer, Steve L Reichow
This corrects the article DOI: 10.1038/ncomms15742.
May 25, 2018: Nature Communications
Caroline H Roney, Jason D Bayer, Hubert Cochet, Marianna Meo, Rémi Dubois, Pierre Jaïs, Edward J Vigmond
Success rates for catheter ablation of persistent atrial fibrillation patients are currently low; however, there is a subset of patients for whom electrical isolation of the pulmonary veins alone is a successful treatment strategy. It is difficult to identify these patients because there are a multitude of factors affecting arrhythmia susceptibility and maintenance, and the individual contributions of these factors are difficult to determine clinically. We hypothesised that the combination of pulmonary vein (PV) electrophysiology and atrial body fibrosis determine driver location and effectiveness of pulmonary vein isolation (PVI)...
May 24, 2018: PLoS Computational Biology
E Scott Sills, Natalie S Rickers, Xiang Li
OBJECTIVE: To describe a non-hysterectomy surgical technique for symptomatic patients with >2 Essure® (Bayer Healthcare, Whippany, New Jersey) devices. DESIGN: Patients (n=4) presented with sharp pelvic pain, irregular vaginal bleeding, dyspareunia, weight gain, hair loss, fatigue, and/or diffuse skin rash, all of which were absent before undergoing hysteroscopic sterilization (HS). Hysterosalpingogram obtained before surgical excision of contraceptive tubal implants confirmed more than two Essure® devices in all patients...
June 1, 2018: Surgical Technology International
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