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https://www.readbyqxmd.com/read/28826718/contrasting-effects-of-selective-magl-and-faah-inhibition-on-dopamine-depletion-and-gdnf-expression-in-a-chronic-mptp-mouse-model-of-parkinson-s-disease
#1
Noemi Pasquarelli, Christoph Porazik, Hanna Bayer, Eva Buck, Stefan Schildknecht, Patrick Weydt, Anke Witting, Boris Ferger
The modulation of the brain endocannabinoid system has been identified as an option to treat neurodegenerative diseases including Parkinson's disease (PD). Especially the elevation of endocannabinoid levels by inhibition of hydrolytic degradation represents a valuable approach. To evaluate whether monoacylglycerol lipase (MAGL) or fatty acid amide hydrolase (FAAH) inhibition could be beneficial for PD, we examined in parallel the therapeutic potential of the highly selective MAGL inhibitor KML29 elevating 2-arachidonoylglyerol (2-AG) levels and the highly selective FAAH inhibitor PF-3845 elevating anandamide (AEA) levels in a chronic methyl-4-phenyl-1,2,3,6-tetrahydropyridine/probenecid (MPTP/probenecid) mouse model of PD...
August 4, 2017: Neurochemistry International
https://www.readbyqxmd.com/read/28821929/magnetic-resonance-cinematography-of-the-fingers-a-3-0-tesla-feasibility-study-with-comparison-of-incremental-and-continuous-dynamic-protocols
#2
Thomas Bayer, Werner Adler, Rolf Janka, Michael Uder, Frank Roemer
OBJECTIVE: To study the feasibility of magnetic resonance cinematography of the fingers (MRCF) with comparison of image quality of different protocols for depicting the finger anatomy during motion. MATERIALS AND METHODS: MRCF was performed during a full flexion and extension movement in 14 healthy volunteers using a finger-gating device. Three real-time sequences (frame rates 17-59 images/min) and one proton density (PD) sequence (3 images/min) were acquired during incremental and continuous motion...
August 19, 2017: Skeletal Radiology
https://www.readbyqxmd.com/read/28820601/negatively-charged-and-dark-excitons-in-cspbbr3-perovskite-nanocrystals-revealed-by-high-magnetic-fields
#3
Damien Canneson, Elena V Shornikova, Dmitri R Yakovlev, Tobias Rogge, Anatolie A Mitioglu, Mariana V Ballottin, Peter C M Christianen, Emmanuel Lhuillier, Manfred Bayer, Louis Biadala
The optical properties of colloidal cesium lead halide perovskite (CsPbBr3) nanocrystals are examined by time-resolved and polarization-resolved spectroscopy in high magnetic fields up to 30 T. We unambiguously show that at cryogenic temperatures the emission is dominated by recombination of negatively charged excitons with radiative decay time of 300 ps. The additional long-lived emission with a decay time of 10-30 ns, which decay time shortens and relative amplitude increases in high magnetic fields, evidence the presence of a dark exciton...
August 18, 2017: Nano Letters
https://www.readbyqxmd.com/read/28819135/ribosomal-transcription-is-regulated-by-pgc-1alpha-and-disturbed-in-huntington-s-disease
#4
Sarah Jesse, Hanna Bayer, Marius C Alupei, Martina Zügel, Medhanie Mulaw, Francesca Tuorto, Silke Malmsheimer, Karmveer Singh, Jürgen Steinacker, Uwe Schumann, Albert C Ludolph, Karin Scharffetter-Kochanek, Anke Witting, Patrick Weydt, Sebastian Iben
PGC-1α is a versatile inducer of mitochondrial biogenesis and responsive to the changing energy demands of the cell. As mitochondrial ATP production requires proteins that derive from translation products of cytosolic ribosomes, we asked whether PGC-1α directly takes part in ribosomal biogenesis. Here, we show that a fraction of cellular PGC-1α localizes to the nucleolus, the site of ribosomal transcription by RNA polymerase I. Upon activation PGC-1α associates with the ribosomal DNA and boosts recruitment of RNA polymerase I and UBF to the rDNA promoter...
August 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28817663/discordance-in-the-diagnosis-of-diabetes-comparison-between-hba1c-and-fasting-plasma-glucose
#5
Lan T Ho-Pham, Uyen D T Nguyen, Truong X Tran, Tuan V Nguyen
OBJECTIVE: HbA1c has been introduced as a complementary diagnostic test for diabetes, but its impact on disease prevalence is unknown. This study evaluated the concordance between HbA1c and fasting plasma glucose (FPG) in the diagnosis of diabetes in the general population. MATERIALS AND METHODS: The study was designed as a population based investigation, with participants being sampled from the Ho Chi Minh City, Vietnam. Blood samples were collected after overnight fasting and analyzed within 4 hours after collection...
2017: PloS One
https://www.readbyqxmd.com/read/28817458/noninvasive-derivation-of-fractional-flow-reserve-from-coronary-computed-tomographic-angiography-a-review
#6
Stewart M Benton, Christian Tesche, Carlo N De Cecco, Taylor M Duguay, U Joseph Schoepf, Richard R Bayer
Coronary computed tomographic angiography (CCTA) has evolved as a rapid and highly sensitive method for the exclusion of obstructive coronary artery disease. Unfortunately, as it pertains to moderate and severe lesions, the ability to discriminate between those that are hemodynamically significant and those that are nonobstructive is lacking. Consequently, this deficiency can result in a significant number of unnecessary referrals for invasive angiography that yields nonobstructive results. Fractional flow reserve (FFR), which assesses the hemodynamic significance of a specific lesion, when performed during invasive angiography, results in improved patient outcomes compared with visual stenosis assessment alone...
August 16, 2017: Journal of Thoracic Imaging
https://www.readbyqxmd.com/read/28815688/bmp2-controls-iron-homeostasis-in-mice-independent-of-bmp6
#7
Susanna Canali, Chia-Yu Wang, Kimberly B Zumbrennen-Bullough, Abraham Bayer, Jodie L Babitt
Hepcidin is a key iron regulatory hormone that controls expression of the iron exporter ferroportin to increase the iron supply when needed to support erythropoiesis and other essential functions, but to prevent the toxicity of iron excess. The bone morphogenetic protein (BMP)-SMAD signaling pathway, through the ligand BMP6 and the co-receptor hemojuvelin, is a central regulator of hepcidin transcription in the liver in response to iron. Here, we show that dietary iron loading has a residual ability to induce Smad signaling and hepcidin expression in Bmp6-/- mice, effects that are blocked by a neutralizing BMP2/4 antibody...
August 17, 2017: American Journal of Hematology
https://www.readbyqxmd.com/read/28811680/the-antimicrobial-peptide-human-beta-defensin-3-is-induced-by-platelet-released-growth-factors-in-primary-keratinocytes
#8
Andreas Bayer, Justus Lammel, Mersedeh Tohidnezhad, Sebastian Lippross, Peter Behrendt, Tim Klüter, Thomas Pufe, Jochen Cremer, Holger Jahr, Franziska Rademacher, Regine Gläser, Jürgen Harder
Platelet-released growth factors (PRGF) and its related clinically used formulations (e.g., Vivostat Platelet-Rich Fibrin (PRF®)) contain a variety of chemokines, cytokines, and growth factors and are therefore used to support healing of chronic, hard-to-heal, or infected wounds. Human beta-defensin-3 (hBD-3) is an antimicrobial peptide inducibly expressed in human keratinocytes especially upon wounding. The potent antimicrobial activity of hBD-3 together with its wound closure-promoting activities suggests that hBD-3 may play a crucial role in wound healing...
2017: Mediators of Inflammation
https://www.readbyqxmd.com/read/28808357/platelet-released-growth-factors-induce-differentiation-of-primary-keratinocytes
#9
Andreas Bayer, Mersedeh Tohidnezhad, Justus Lammel, Sebastian Lippross, Peter Behrendt, Tim Klüter, Thomas Pufe, Holger Jahr, Jochen Cremer, Franziska Rademacher, Regine Gläser, Jürgen Harder
Autologous thrombocyte concentrate lysates, for example, platelet-released growth factors, (PRGFs) or their clinically related formulations (e.g., Vivostat PRF®) came recently into the physicians' focus as they revealed promising effects in regenerative and reparative medicine such as the support of healing of chronic wounds. To elucidate the underlying mechanisms, we analyzed the influence of PRGF and Vivostat PRF on human keratinocyte differentiation in vitro and on epidermal differentiation status of skin wounds in vivo...
2017: Mediators of Inflammation
https://www.readbyqxmd.com/read/28792633/evolutionarily-diverse-syp1-qa-snares-jointly-sustain-pollen-tube-growth-in-arabidopsis
#10
Daniel Slane, Ilka Reichardt, Farid El Kasmi, Martin Bayer, Gerd Jürgens
Intracellular membrane fusion is effected by SNARE proteins that reside on adjacent membranes and form bridging trans-SNARE complexes. Qa-SNARE members of the Arabidopsis SYP1 family are involved in membrane fusion at the plasma membrane or during cell plate formation. Three SYP1 family members have been classified as pollen-specific as inferred from gene expression profiling studies and two of them, SYP124 and SYP125, are confined to angiosperms. The SYP124 gene appears genetically unstable whereas its sister gene SYP125 shows essentially no variation among Arabidopsis accessions...
August 9, 2017: Plant Journal: for Cell and Molecular Biology
https://www.readbyqxmd.com/read/28792104/expression-analysis-of-cellulose-synthase-and-main-cytoskeletal-protein-genes-in-flax-linum-usitatissimum-l
#11
Dmitry Galinousky, Tsimafei Padvitski, Galina Bayer, Yaroslav Pirko, Nikolay Pydiura, Natallia Anisimova, Tatyana Nikitinskaya, Liubov Khotyleva, Alla Yemets, Aleksandr Kilchevsky, Yaroslav Blume
Fiber flax is an important source of natural fiber and a comprehensive model for the plant fiber biogenesis studies. Cellulose-synthase (CesA) and cytoskeletal genes are known to be important for the cell wall biogenesis in general and for the biogenesis of flax fibers in particular. Currently, knowledge about activity of these genes during the plant growth is limited. In this study, we have investigated flax fiber biogenesis by measuring expression of CesA and cytoskeletal genes at two stages of the flax development (seedlings and stems at the rapid growth stage) in several flax subspecies (elongatum, mediterraneum, crepitans)...
August 9, 2017: Cell Biology International
https://www.readbyqxmd.com/read/28774818/the-protective-effect-of-platelet-released-growth-factors-and-bone-augmentation-bio-oss-%C3%A2-on-ethanol-impaired-osteoblasts
#12
Tolga Taha Sönmez, Andreas Bayer, Tillman Cremer, Jennifer Vanessa Phi Hock, Bernd Lethaus, Nisreen Kweider, Christoph Jan Wruck, Wolf Drescher, Holger Jahr, Sebastian Lippross, Thomas Pufe, Mersedeh Tohidnezhad
BACKGROUND: Chronic alcohol consumption is a known limiting factor for bone healing. One promising strategy to improve bone augmentation techniques with Bio-Oss(®) in oral and maxillofacial surgery might be the supportive application of platelet-concentrated biomaterials as platelet-released growth factor (PRGF). To address this matter, we performed an in vitro study investigating the protective effects of PRGF and Bio-Oss(®) in ethanol (EtOH) treated osteoblasts. METHODS: The SAOS-2 osteosarcoma cell line, with and without EtOH pretreatment was used...
July 31, 2017: Annals of Anatomy, Anatomischer Anzeiger: Official Organ of the Anatomische Gesellschaft
https://www.readbyqxmd.com/read/28774003/investigation-of-electric-field-induced-structural-changes-at-fe-doped-srtio%C3%A2-anode-interfaces-by-second-harmonic-generation
#13
David Ascienzo, Haochen Yuan, Steve Greenbaum, Thorsten J M Bayer, Russell A Maier, Jian-Jun Wang, Clive A Randall, Elizabeth C Dickey, Haibin Zhao, Yuhang Ren
We report on the detection of electric field-induced second harmonic generation (EFISHG) from the anode interfaces of reduced and oxidized Fe-doped SrTiO₃ (Fe:STO) single crystals. For the reduced crystal, we observe steady enhancements of the susceptibility components as the imposed dc-voltage increases. The enhancements are attributed to a field-stabilized electrostriction, leading to Fe:Ti-O bond stretching and bending in Fe:Ti-O₆ octahedra. For the oxidized crystal, no obvious structural changes are observed below 16 kV/cm...
October 31, 2016: Materials
https://www.readbyqxmd.com/read/28773109/thermomechanical-properties-of-polylactic-acid-graphene-composites-a-state-of-the-art-review-for-biomedical-applications
#14
REVIEW
Ilker S Bayer
Due to its biodegradable and bioabsorbable characteristics polylactic acid (PLA) has attracted considerable attention for numerous biomedical applications. Moreover, a number of tissue engineering problems for function restoration of impaired tissues have been addressed by using PLA and its copolymers due to their biocompatibility and distinctive mechanical properties. Recent studies on various stereocomplex formation between enantiomeric PLA, poly(l-lactide) (PLLA) and poly(d-lactide) (PDLA) indicated that stereocomplexation enhances the mechanical properties as well as the thermal- and hydrolysis-resistance of PLA polymers...
July 4, 2017: Materials
https://www.readbyqxmd.com/read/28768877/immunodominance-of-adenovirus-derived-cd8-t-cell-epitopes-interferes-with-the-induction-of-transgene-specific-immunity-in-adenovirus-based-immunization
#15
Dominik Schöne, Camilla Patrizia Hrycak, Sonja Windmann, Dennis Lapuente, Ulf Dittmer, Matthias Tenbusch, Wibke Bayer
Adenovirus (Ad)-based immunization is a popular approach in vaccine development, and Ad-based vectors are renowned for their potential to induce strong CD8(+) T cell responses to the encoded transgene. Surprisingly, we found before in the mouse Friend retrovirus (FV) model that Ad-based immunization did not induce CD8(+) T cell responses to the FV Leader-Gag-derived immunodominant epitope GagL85-93 We show now that induction of GagL85-93-specific CD8(+) T cells was highly effective when Leader-Gag was delivered by plasmid DNA immunization, implying a role for Ad-derived epitopes in mediating unresponsiveness...
August 2, 2017: Journal of Virology
https://www.readbyqxmd.com/read/28763608/s2k-leitlinie-zur-diagnostik-und-therapie-des-chronischen-pruritus-update-kurzversion
#16
Sonja Ständer, Claudia Zeidler, Matthias Augustin, Gudrun Bayer, Andreas E Kremer, Franz J Legat, Peter Maisel, Thomas Mettang, Martin Metz, Alexander Nast, Volker Niemeier, Ulrike Raap, Gudrun Schneider, Hartmut F Ständer, Petra Staubach, Markus Streit, Elke Weisshaar
No abstract text is available yet for this article.
August 2017: Journal der Deutschen Dermatologischen Gesellschaft, Journal of the German Society of Dermatology: JDDG
https://www.readbyqxmd.com/read/28763584/s2k-guidelines-for-the-diagnosis-and-treatment-of-chronic-pruritus-update-short-version
#17
Sonja Ständer, Claudia Zeidler, Matthias Augustin, Gudrun Bayer, Andreas E Kremer, Franz J Legat, Peter Maisel, Thomas Mettang, Martin Metz, Alexander Nast, Volker Niemeier, Ulrike Raap, Gudrun Schneider, Hartmut F Ständer, Petra Staubach, Markus Streit, Elke Weisshaar
Associated with a host of different diseases, pruritus is a cardinal symptom that poses an interdisciplinary diagnostic and therapeutic challenge. Over time, that symptom may progress independently of the initial cause, thus losing its function as a warning sign and turning into a clinically relevant disease of its own. In Germany, approximately 13.5 % of the general population are affected by chronic pruritus, with an incidence of 7 %. All forms of chronic pruritus require targeted treatment consisting of (a) diagnosis and management of the underlying disease, (b) dermatological treatment of primary or secondary (for example, dry skin, scratch lesions) symptoms, (c) symptomatic antipruritic treatment, and (d) psychological/psychotherapeutic treatment in case of an underlying or associated psychological or psychosomatic condition...
August 2017: Journal der Deutschen Dermatologischen Gesellschaft, Journal of the German Society of Dermatology: JDDG
https://www.readbyqxmd.com/read/28758890/structural-basis-for-plant-plasma-membrane-protein-dynamics-and-organization-into-functional-nanodomains
#18
Julien Gronnier, Jean-Marc Crowet, Birgit Habenstein, Mehmet Nail Nasir, Vincent Bayle, Eric Hosy, Matthieu Pierre Platre, Paul Gouguet, Sylvain Raffaele, Denis Martinez, Axelle Grelard, Antoine Loquet, Françoise Simon-Plas, Patricia Gerbeau-Pissot, Christophe Der, Emmanuelle M Bayer, Yvon Jaillais, Magali Deleu, Véronique Germain, Laurence Lins, Sébastien Mongrand
Plasma Membrane is the primary structure for adjusting to ever changing conditions. PM sub-compartmentalization in domains is thought to orchestrate signaling. Yet, mechanisms governing membrane organization are mostly uncharacterized. The plant-specific REMORINs are proteins regulating hormonal crosstalk and host invasion. REMs are the best-characterized nanodomain markers via an uncharacterized moiety called REMORIN C-terminal Anchor. By coupling biophysical methods, super-resolution microscopy and physiology, we decipher an original mechanism regulating the dynamic and organization of nanodomains...
July 31, 2017: ELife
https://www.readbyqxmd.com/read/28750628/what-works-for-whom-in-the-management-of-diabetes-in-people-living-with-dementia-a-realist-review
#19
Frances Bunn, Claire Goodman, Peter Reece Jones, Bridget Russell, Daksha Trivedi, Alan Sinclair, Antony Bayer, Greta Rait, Jo Rycroft-Malone, Christopher Burton
BACKGROUND: Dementia and diabetes mellitus are common long-term conditions and co-exist in a large number of older people. People living with dementia (PLWD) may be less able to manage their diabetes, putting them at increased risk of complications such as hypoglycaemia. The aim of this review was to identify key mechanisms within different interventions that are likely to improve diabetes outcomes in PLWD. METHODS: This is a realist review involving scoping of the literature and stakeholder interviews to develop theoretical explanations of how interventions might work, systematic searches of the evidence to test and develop the theories and their validation with a purposive sample of stakeholders...
July 28, 2017: BMC Medicine
https://www.readbyqxmd.com/read/28732871/cellulose-polyhydroxylated-fatty-acid-ester-based-bioplastics-with-tuning-properties-acylation-via-a-mixed-anhydride-system
#20
José A Heredia-Guerrero, Luca Goldoni, José J Benítez, Alexander Davis, Luca Ceseracciu, Roberto Cingolani, Ilker S Bayer, Thomas Heinze, Andreas Koschella, Antonio Heredia, Athanassia Athanassiou
The synthesis of microcrystalline cellulose (MCC) and 9,10,16-hydroxyhexadecanoic (aleuritic) acid ester-based bioplastics was investigated through acylation in a mixed anhydride (trifluoroacetic acid (TFA)/trifluoroacetic acid anhydride (TFAA)), chloroform co-solvent system. The effects of chemical interactions and the molar ratio of aleuritic acid to the anhydroglucose unit (AGU) of cellulose were investigated. The degree of substitution (DS) of new polymers were characterized by two-dimensional solution-state NMR and ranged from 0...
October 1, 2017: Carbohydrate Polymers
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