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https://www.readbyqxmd.com/read/29453253/assembly-of-synthetic-functional-cellulosomal-structures-onto-the-lactobacillus-plantarum-cell-surface-a-potent-member-of-the-gut-microbiome
#1
Johanna Stern, Sarah Moraïs, Yonit Ben-David, Rachel Salama, Melina Shamshoum, Raphael Lamed, Yuval Shoham, Edward A Bayer, Itzhak Mizrahi
Heterologous display of enzymes on microbial cell surfaces is an extremely desirable approach, since it enables the engineered microbe to interact directly with the plant-wall extracellular polysaccharide matrix. In recent years, attempts have been made to endow non-cellulolytic microbes with genetically engineered cellulolytic capabilities for improved hydrolysis of lignocellulosic biomass and for advanced probiotics. Thus far, however, owing to the hurdles of secreting and assembling large, intricate complexes on the bacterial cell wall, only free cellulases or relatively simple cellulosome assemblies have been introduced into live bacteria...
February 16, 2018: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/29449327/kyleena-another-levonorgestrel-ius
#2
(no author information available yet)
A levonorgestrel (LNG) intrauterine system (IUS) known as Kyleena (Bayer PLC) received marketing authorisation from the European Medicines Agency in 2016. 1 The device contains 19.5mg LNG and is licensed for contraception for up to 5 years. This is the fourth LNG IUS product to be licensed for use in the UK. The company states that Kyleena offers advantages over Mirena and Jaydess LNG IUS devices. 2 Here we consider the evidence for Kyleena.
February 2018: Drug and Therapeutics Bulletin
https://www.readbyqxmd.com/read/29444157/does-radiation-therapy-increase-gadolinium-accumulation-in-the-brain-quantitative-analysis-of-t1-shortening-using-r1-relaxometry-in-glioblastoma-multiforme-patients
#3
Woo Hyeon Lim, Seung Hong Choi, Roh-Eul Yoo, Koung Mi Kang, Tae Jin Yun, Ji-Hoon Kim, Chul-Ho Sohn
OBJECTIVE: This study evaluated the possibility of accelerated gadolinium accumulation in irradiated brain parenchyma where the blood-brain barrier was weakened. METHODS: From January 2010 to June 2015, 44 patients with supratentorial glioblastoma were retrospectively identified who underwent pre- and post-radiation brain MR imaging, including R1 mapping. The mean dose of administered gadobutrol (Gadovist, Bayer, Germany) was 5.1 vials. Regions of interest (ROIs) were drawn around tumors that were located within 50-100% iso-dose lines of maximum radiation dose...
2018: PloS One
https://www.readbyqxmd.com/read/29441526/effects-of-parental-care-on-resource-allocation-into-immune-defense-and-buccal-microbiota-in-mouthbrooding-cichlid-fishes
#4
Isabel S Keller, Till Bayer, Walter Salzburger, Olivia Roth
Sexual dimorphism is founded upon a resource allocation trade-off between investments in reproduction versus other life-history traits including the immune system. In species with conventional parental care roles, theory predicts that males maximize their lifetime reproductive success by allocating resources towards sexual selection, while females achieve this through prolonging their lifespan. Here, we examine the interrelation between sexual dimorphism and parental care strategies in closely related maternal and biparental mouthbrooding cichlid fishes from East African Lake Tanganyika...
February 14, 2018: Evolution; International Journal of Organic Evolution
https://www.readbyqxmd.com/read/29441012/a-modified-reading-the-mind-in-the-eyes-test-predicts-behavioral-variant-frontotemporal-dementia-better-than-executive-function-tests
#5
Matthias L Schroeter, Sarah Pawelke, Sandrine Bisenius, Jana Kynast, Katharina Schuemberg, Maryna Polyakova, Sarah Anderl-Straub, Adrian Danek, Klaus Fassbender, Holger Jahn, Frank Jessen, Johannes Kornhuber, Martin Lauer, Johannes Prudlo, Anja Schneider, Ingo Uttner, Angelika Thöne-Otto, Markus Otto, Janine Diehl-Schmid
Behavioral variant frontotemporal dementia (bvFTD) is characterized by deep alterations in behavior and personality. Although revised diagnostic criteria agree for executive dysfunction as most characteristic, impairments in social cognition are also suggested. The study aimed at identifying those neuropsychological and behavioral parameters best discriminating between bvFTD and healthy controls. Eighty six patients were diagnosed with possible or probable bvFTD according to Rascovsky et al. (2011) and compared with 43 healthy age-matched controls...
2018: Frontiers in Aging Neuroscience
https://www.readbyqxmd.com/read/29440592/eligulum-a-regulates-lateral-branch-and-leaf-development-in-barley
#6
Ron J Okagaki, Allison Haaning, Hatice Bilgic, Shane Heinen, Arnis Druka, Micha Bayer, Robbie Waugh, Gary J Muehlbauer
The shoot apical and axillary meristems control shoot development, effectively influencing lateral branch and leaf formation. The barley (Hordeum vulgare L.) uniculm2 (cul2) mutation blocks axillary meristem development and mutant plants lack lateral branches (tillers) that normally develop from the crown. A genetic screen for cul2 suppressors recovered two recessive alleles of ELIGULUM-A (ELI-A) that partially rescued the cul2 tillering phenotype. Mutations in ELI-A produce shorter plants with fewer tillers and disrupt the leaf blade-sheath boundary, producing liguleless leaves and reduced secondary cell wall development in stems and leaves...
February 12, 2018: Plant Physiology
https://www.readbyqxmd.com/read/29439869/immunization-with-an-adjuvanted-low-energy-electron-irradiation-inactivated-respiratory-syncytial-virus-vaccine-shows-immunoprotective-activity-in-mice
#7
Lea Bayer, Jasmin Fertey, Sebastian Ulbert, Thomas Grunwald
Respiratory syncytial virus (RSV) is a pathogen causing severe lower respiratory tract disease in infants and the elderly. In spite of the great need for a vaccine against RSV, currently there is no licensed product on the market. A very early vaccine candidate developed in the 1960s based on formaldehyde inactivation (FI) turned out to instead enhance the disease. Our novel inactivation method applied low-energy electron irradiation (LEEI) to produce a killed RSV vaccine. LEEI yielded inactivated virus particles with a reproducible virus antigen conservation above 70%, while FI resulted in highly variable antigen conservation...
February 10, 2018: Vaccine
https://www.readbyqxmd.com/read/29439480/appropriate-handling-processing-and-analysis-of-blood-samples-is-essential-to-avoid-oxidation-of-vitamin-c-to-dehydroascorbic-acid
#8
Juliet M Pullar, Simone Bayer, Anitra C Carr
Vitamin C (ascorbate) is the major water-soluble antioxidant in plasma and its oxidation to dehydroascorbic acid (DHA) has been proposed as a marker of oxidative stress in vivo. However, controversy exists in the literature around the amount of DHA detected in blood samples collected from various patient cohorts. In this study, we report on DHA concentrations in a selection of different clinical cohorts (diabetes, pneumonia, cancer, and critically ill). All clinical samples were collected into EDTA anticoagulant tubes and processed at 4 °C prior to storage at -80 °C for subsequent analysis by HPLC with electrochemical detection...
February 11, 2018: Antioxidants (Basel, Switzerland)
https://www.readbyqxmd.com/read/29437917/colocalization-and-disposition-of-cellulosomes-in-clostridium-clariflavum-as-revealed-by-correlative-superresolution-imaging
#9
Lior Artzi, Tali Dadosh, Elad Milrot, Sarah Moraïs, Smadar Levin-Zaidman, Ely Morag, Edward A Bayer
Cellulosomes are multienzyme complexes produced by anaerobic, cellulolytic bacteria for highly efficient breakdown of plant cell wall polysaccharides. Clostridium clariflavum is an anaerobic, thermophilic bacterium that produces the largest assembled cellulosome complex in nature to date, comprising three types of scaffoldins: a primary scaffoldin, ScaA; an adaptor scaffoldin, ScaB; and a cell surface anchoring scaffoldin, ScaC. This complex can contain 160 polysaccharide-degrading enzymes. In previous studies, we proposed potential types of cellulosome assemblies in C...
February 6, 2018: MBio
https://www.readbyqxmd.com/read/29436260/treatment-patterns-and-associated-health-care-costs-before-and-after-treatment-initiation-among-pulmonary-arterial-hypertension-patients-in-the-united-states
#10
Charles D Burger, A Burak Ozbay, Howard M Lazarus, Ellen Riehle, Leslie B Montejano, Gregory Lenhart, R James White
BACKGROUND: Despite multiple treatment options, the prognosis of pulmonary arterial hypertension (PAH) remains poor. PAH patients experience a high economic burden due to comorbidities, hospitalizations, and medication costs. Although combination therapy has been shown to reduce hospitalizations, the relationship between treatment, health care utilization, and costs remains unclear. OBJECTIVE: To provide a characterization of health care utilization and costs in real-world settings by comparing periods before and after initiating PAH-specific treatment...
February 13, 2018: Journal of Managed Care & Specialty Pharmacy
https://www.readbyqxmd.com/read/29434658/healthy-living-and-cancer-evidence-from-uk-biobank
#11
Peter C Elwood, Alex Whitmarsh, John Gallacher, Anthony Bayer, Richard Adams, Luke Heslop, Janet Pickering, Gareth Morgan, Julieta Galante, Sunil Dolwani, Marcus Longley, Zoe E Roberts
Context: UK Biobank is a prospective study of half a million subjects, almost all aged 40-69 years, identified in 22 centres across the UK during 2006-2010. Objective: A healthy lifestyle has been described as 'better than any pill, and no side effects [5]. We therefore examined the relationships between healthy behaviours: low alcohol intake, non-smoking, healthy BMI, physical activity and a healthy diet, and the risk of all cancers, colon, breast and prostate cancers in a large dataset...
2018: Ecancermedicalscience
https://www.readbyqxmd.com/read/29432519/the-role-of-biomarkers-and-imaging-in-the-clinical-diagnosis-of-dementia
#12
Antony J Bayer
Recognition of dementia relies on a good clinical history, supported by formal cognitive testing, but identifying the subtype of dementia may be wrong in 20% or more of cases. Accuracy may be improved by use of imaging and cerebrospinal fluid (CSF) biomarkers. Structural neuroimaging is recommended for most patients, not just to identify potentially reversible surgical pathology, but also to detect vascular changes and patterns of cerebral atrophy. Functional imaging can help to confirm neurodegeneration and to distinguish dementia subtypes when structural imaging has been inconclusive...
February 8, 2018: Age and Ageing
https://www.readbyqxmd.com/read/29427275/linear-and-non-linear-impact-of-internet-usage-and-financial-deepening-on-electricity-consumption-for-turkey-empirical-evidence-from-asymmetric-causality
#13
Faisal Faisal, Turgut Tursoy, Niyazi Berk
This study investigates the relationship between Internet usage, financial development, economic growth, capital and electricity consumption using quarterly data from 1993Q1 to 2014Q4. The integration order of the series is analysed using the structural break unit root test. The ARDL bounds test for cointegration in addition to the Bayer-Hanck (2013) combined cointegration test is applied to analyse the existence of cointegration among the variables. The study found strong evidence of a long-run relationship between the variables...
February 9, 2018: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29422307/percutaneous-treatment-of-orofacial-vascular-malformations
#14
A Sindel, A Sayan, Ö Özgür, T Sindel, V Ilankovan
The aim of this study was to evaluate the efficacy of fluoroscopy-guided percutaneous injection of bleomycin as the primary treatment for low-flow vascular malformations. A total of 34 patients (mean (range) age 24 (8-51) years) with orofacial vascular lesions were treated in the Department of Interventional Radiology and Maxillofacial Surgery. There were 20 low-flow venous malformations, 11 lymphatic malformations, and three of mixed type. All patients were treated by fluoroscopy-guided percutaneous injection of a mixture of bleomycin (mean (range) 15 (5-15)mg) and a radio-opaque agent (Ultravist® (iopromide), Bayer)/session...
February 5, 2018: British Journal of Oral & Maxillofacial Surgery
https://www.readbyqxmd.com/read/29420315/prolonged-catheter-use-and-infection-in-regional-anesthesia-a-retrospective-registry-analysis
#15
Hagen Bomberg, Ina Bayer, Stefan Wagenpfeil, Paul Kessler, Hinnerk Wulf, Thomas Standl, André Gottschalk, Jens Döffert, Werner Hering, Jürgen Birnbaum, Claudia Spies, Bernd Kutter, Jörg Winckelmann, Simone Liebl-Biereige, Winfried Meissner, Oliver Vicent, Thea Koch, Daniel I Sessler, Thomas Volk, Alexander Raddatz
BACKGROUND: Prolonged catheter use is controversial because of the risk of catheter-related infection, but the extent to which the risk increases over time remains unknown. We thus assessed the time-dependence of catheter-related infection risk up to 15 days. METHODS: Our analysis was based on the German Network for Regional Anesthesia, which includes 25 centers. We considered 44,555 patients who had surgery between 2007 and 2014 and had continuous regional anesthesia as well as complete covariable details...
February 8, 2018: Anesthesiology
https://www.readbyqxmd.com/read/29419930/stat1-is-a-sex-specific-tumor-suppressor-in-colitis-associated-colorectal-cancer
#16
Ilija Crnčec, Madhura Modak, Claire Gordziel, Jasmin Svinka, Irene Scharf, Stefan Moritsch, Paulina Pathria, Michaela Schlederer, Lukas Kenner, Gerald Timelthaler, Mathias Müller, Birgit Strobl, Emilio Casanova, Editha Bayer, Thomas Mohr, Johannes Stöckl, Karlheinz Friedrich, Robert Eferl
The interferon-inducible transcription factor STAT1 is a tumor suppressor in various malignancies. We investigated sex-specific STAT1 functions in colitis and colitis-associated colorectal cancer (CRC) using mice with specific STAT1 deletion in intestinal epithelial cells (STAT1 ∆ IEC ). Male but not female STAT1 ∆ IEC mice were more resistant to DSS-induced colitis than sex-matched STAT1 flox/flox controls and displayed reduced intraepithelial infiltration of CD8 + TCRαβ + Granzyme B + T cells. Moreover, DSS treatment failed to induce expression of T cell-attracting chemokines in intestinal epithelial cells of male but not of female STAT1 ∆ IEC mice...
February 8, 2018: Molecular Oncology
https://www.readbyqxmd.com/read/29414438/universal-ventricular-coordinates-a-generic-framework-for-describing-position-within-the-heart-and-transferring-data
#17
Jason Bayer, Anton J Prassl, Ali Pashaei, Juan F Gomez, Antonio Frontera, Aurel Neic, Gernot Plank, Edward J Vigmond
Being able to map a particular set of cardiac ventricles to a generic topologically equivalent representation has many applications, including facilitating comparison of different hearts, as well as mapping quantities and structures of interest between them. In this paper we describe Universal Ventricular Coordinates (UVC), which can be used to describe position within any biventricular heart. UVC comprise four unique coordinates that we have chosen to be intuitive, well defined, and relevant for physiological descriptions...
February 1, 2018: Medical Image Analysis
https://www.readbyqxmd.com/read/29396117/concerted-action-of-evolutionarily-ancient-and-novel-snare-complexes-in-flowering-plant-cytokinesis
#18
Misoon Park, Cornelia Krause, Matthias Karnahl, Ilka Reichardt, Farid El Kasmi, Ulrike Mayer, York-Dieter Stierhof, Ulrike Hiller, Georg Strompen, Martin Bayer, Marika Kientz, Masa H Sato, Marc T Nishimura, Jeffery L Dangl, Anton A Sanderfoot, Gerd Jürgens
Membrane vesicles delivered to the cell-division plane fuse with one another to form the partitioning membrane during plant cytokinesis, starting in the cell center. In Arabidopsis, this requires SNARE complexes involving the cytokinesis-specific Qa-SNARE KNOLLE. However, cytokinesis still occurs in knolle mutant embryos, suggesting contributions from KNOLLE-independent SNARE complexes. Here we show that Qa-SNARE SYP132, having counterparts in lower plants, functionally overlaps with the flowering plant-specific KNOLLE...
January 26, 2018: Developmental Cell
https://www.readbyqxmd.com/read/29385307/interrupted-bayer-villiger-rearrangement-building-a-stereoelectronic-trap-for-the-criegee-intermediate
#19
Vera Vil', Gabriel Dos Passos Gomes, Oleg Bityukov, Konstantin Lyssenko, Gennady Nikishin, Igor Alabugin, Alexander Terent'ev
The instability of hydroxyl peroxyesters, the elusive Criegee intermediates of the Bayer-Villiger rearrangement, can be alleviated by selective deactivation of stereoelectronic effects that promote the 1,2-alkyl shift. Stable cyclic Criegee intermediates constrained within a five-membered ring can be prepared by mild reduction of respective hydroperoxyl peroxyesters (β-hydroperoxy-β-peroxylactones) which were formed in high yields in reaction of β-ketoesters with BF3·Et2O/H2O2.
January 31, 2018: Angewandte Chemie
https://www.readbyqxmd.com/read/29383980/optimizing-anti-vegf-treatment-outcomes-for-patients-with-neovascular-age-related-macular-degeneration
#20
Charles C Wykoff, W Lloyd Clark, Jared S Nielsen, Joel V Brill, Laurence S Greene, Cherilyn L Heggen
BACKGROUND: The introduction of anti-vascular endothelial growth factor (anti-VEGF) drugs to ophthalmology has revolutionized the treatment of neovascular age-related macular degeneration (nAMD). Despite this significant progress, gaps and challenges persist in the diagnosis of nAMD, initiation of treatment, and management of frequent intravitreal injections. Thus, nAMD remains a leading cause of blindness in the United States. OBJECTIVE: To present current knowledge, evidence, and expert perspectives on anti-VEGF therapies in nAMD to support managed care professionals and providers in decision making and collaborative strategies to overcome barriers to optimize anti-VEGF treatment outcomes among nAMD patients...
February 2018: Journal of Managed Care & Specialty Pharmacy
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