keyword
MENU ▼
Read by QxMD icon Read
search

Bayer

keyword
https://www.readbyqxmd.com/read/28211728/electron-vortices-in-femtosecond-multiphoton-ionization
#1
D Pengel, S Kerbstadt, D Johannmeyer, L Englert, T Bayer, M Wollenhaupt
Multiphoton ionization of potassium atoms with a sequence of two counter-rotating circularly polarized femtosecond laser pulses produces vortex-shaped photoelectron momentum distributions in the polarization plane describing Archimedean spirals. The pulse sequences are produced by polarization shaping and the three-dimensional photoelectron distributions are tomographically reconstructed from velocity map imaging measurements. We show that perturbative ionization leads to electron vortices with c_{6} rotational symmetry...
February 3, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/28202322/sexual-health-competencies-for-undergraduate-medical-education-in-north-america
#2
Carey Roth Bayer, Kristen L Eckstrand, Gail Knudson, Jean Koehler, Scott Leibowitz, Perry Tsai, Jamie L Feldman
INTRODUCTION: The number of hours spent teaching sexual health content and skills in medical education continues to decrease despite the increase in sexual health issues faced by patients across the lifespan. In 2012 and 2014, experts across sexuality disciplines convened for the Summits on Medical School Education and Sexual Health to strategize and recommend approaches to improve sexual health education in medical education systems and practice settings. One of the summit recommendations was to develop sexual health competencies that could be implemented in undergraduate medical education curricula...
February 12, 2017: Journal of Sexual Medicine
https://www.readbyqxmd.com/read/28194067/evaluation-of-the-sensitivity-and-specificity-of-use-of-glucose-and-ph-for-bacterial-screening-of-platelet-concentrates-compared-to-the-bact-alert
#3
Farhad Razjou, Hossein Timori Naghadeh, Shirin Ferdowsi, Abolfazl Dabirmoghadam
Bacterial contamination of blood components is the major infectious risk in transfusion medicine. Since platelets should be stored at room temperature that makes them an excellent growth medium for bacteria; it is mentioned as a major problem in transfusion medicine. Transfusion risk of a bacterial contaminated platelet concentrate is higher than viral pathogen such as HIV, HBV, HCV and HTLV. The objective of this study was to evaluation of the sensitivity and specificity of use of glucose and pH for bacterial screening of platelet concentrates compared to the Bact/Alert...
March 2017: Indian Journal of Hematology & Blood Transfusion
https://www.readbyqxmd.com/read/28186207/complexity-of-the-ruminococcus-flavefaciens-fd-1-cellulosome-reflects-an-expansion-of-family-related-protein-protein-interactions
#4
Vered Israeli-Ruimy, Pedro Bule, Sadanari Jindou, Bareket Dassa, Sarah Moraïs, Ilya Borovok, Yoav Barak, Michal Slutzki, Yuval Hamberg, Vânia Cardoso, Victor D Alves, Shabir Najmudin, Bryan A White, Harry J Flint, Harry J Gilbert, Raphael Lamed, Carlos M G A Fontes, Edward A Bayer
Protein-protein interactions play a vital role in cellular processes as exemplified by assembly of the intricate multi-enzyme cellulosome complex. Cellulosomes are assembled by selective high-affinity binding of enzyme-borne dockerin modules to repeated cohesin modules of structural proteins termed scaffoldins. Recent sequencing of the fiber-degrading Ruminococcus flavefaciens FD-1 genome revealed a particularly elaborate cellulosome system. In total, 223 dockerin-bearing ORFs potentially involved in cellulosome assembly and a variety of multi-modular scaffoldins were identified, and the dockerins were classified into six major groups...
February 10, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28185007/the-rostromedial-zona-incerta-is-involved-in-attentional-processes-while-adjacent-lha-responds-to-arousal-c-fos-and-anatomical-evidence
#5
S Chometton, K Charrière, L Bayer, C Houdayer, G Franchi, F Poncet, D Fellmann, P Y Risold
Neurons producing melanin-concentrating hormone (MCH) are located in the tuberal lateral hypothalamus (LHA) and in the rostromedial part of the zona incerta (ZI). This distribution suggests that rostromedial ZI shares some common features with the LHA. However, its functions with regard to arousal or feeding, which are often associated with the LHA, have not been thoroughly investigated. This study analyses the responses in the tuberal LHA and adjacent rostromedial ZI after experiments related to arousal, exploration, food teasing and ingestive behavior...
February 9, 2017: Brain Structure & Function
https://www.readbyqxmd.com/read/28182171/early-clinical-features-of-pseudoexfoliation-syndrome-in-anterior-segment-and-gonioscopy-examination
#6
Sirel Gür Güngör, Atilla Bayer, Ahmet Akman, Leyla Asena
OBJECTIVES: To determine the early signs of pseudoexfoliation (PEX) in fellow eyes of cases with unilateral PEX. MATERIALS AND METHODS: Fellow eyes of 34 cases with unilateral PEX were evaluated by slit-lamp and gonioscopy. Findings associated with PEX were recorded. RESULTS: Mean age was 67.8±8.1 years (range 55-86 years). Twenty-five patients (73.5%) had pigmentation in the inferior angle and 23 patients (67.6%) had Sampaolesi's line located on the inferior angle in fellow eyes...
January 2017: Turkish Journal of Ophthalmology
https://www.readbyqxmd.com/read/28166802/induction-of-complex-immune-responses-and-strong-protection-against-retrovirus-challenge-by-adenovirus-based-immunization-depends-on-the-order-of-vaccine-delivery
#7
Meike Kaulfuß, Ina Wensing, Sonja Windmann, Camilla Patrizia Hrycak, Wibke Bayer
BACKGROUND: In the Friend retrovirus mouse model we developed potent adenovirus-based vaccines that were designed to induce either strong Friend virus GagL85-93-specific CD8(+) T cell or antibody responses, respectively. To optimize the immunization outcome we evaluated vaccination strategies using combinations of these vaccines. RESULTS: While the vaccines on their own confer strong protection from a subsequent Friend virus challenge, the simple combination of the vaccines for the establishment of an optimized immunization protocol did not result in a further improvement of vaccine effectivity...
February 6, 2017: Retrovirology
https://www.readbyqxmd.com/read/28165425/g-channel-restoration-for-rwb-cfa-with-double-exposed-w-channel
#8
Chulhee Park, Ki Sun Song, Moon Gi Kang
In this paper, we propose a green (G)-channel restoration for a red-white-blue (RWB) color filter array (CFA) image sensor using the dual sampling technique. By using white (W) pixels instead of G pixels, the RWB CFA provides high-sensitivity imaging and an improved signal-to-noise ratio compared to the Bayer CFA. However, owing to this high sensitivity, the W pixel values become rapidly over-saturated before the red-blue (RB) pixel values reach the appropriate levels. Because the missing G color information included in the W channel cannot be restored with a saturated W, multiple captures with dual sampling are necessary to solve this early W-pixel saturation problem...
February 5, 2017: Sensors
https://www.readbyqxmd.com/read/28159788/revisiting-the-regulation-of-the-primary-scaffoldin-gene-in-clostridium-thermocellum
#9
Lizett Ortiz de Ora, Iván Muñoz-Gutiérrez, Edward A Bayer, Yuval Shoham, Raphael Lamed, Ilya Borovok
: Cellulosomes are considered to be one of the most efficient systems for degradation of plant cell-wall polysaccharides. The central cellulosome component comprises a large, noncatalytic, protein subunit called scaffoldin. Multiple saccharolytic enzymes are incorporated into the scaffoldins via specific high-affinity cohesin-dockerin interactions. Recently, the regulation of genes encoding certain cellulosomal components by multiple RNA polymerase alternative σ(I) factors has been demonstrated in Clostridium (Ruminiclostridium) thermocellum In the present report, we provide experimental evidence demonstrating that the C...
February 3, 2017: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/28158308/inefficiencies-and-patient-burdens-in-the-development-of-the-targeted-cancer-drug-sorafenib-a-systematic-review
#10
James Mattina, Benjamin Carlisle, Yasmina Hachem, Dean Fergusson, Jonathan Kimmelman
Failure in cancer drug development exacts heavy burdens on patients and research systems. To investigate inefficiencies and burdens in targeted drug development in cancer, we conducted a systematic review of all prelicensure trials for the anticancer drug, sorafenib (Bayer/Onyx Pharmaceuticals). We searched Embase and MEDLINE databases on October 14, 2014, for prelicensure clinical trials testing sorafenib against cancers. We measured risk by serious adverse event rates, benefit by objective response rates and survival, and trial success by prespecified primary endpoint attainment with acceptable toxicity...
February 2017: PLoS Biology
https://www.readbyqxmd.com/read/28148274/severity-dependent-differences-in-early-management-of-thoracic-trauma-in-severely-injured-patients%C3%A2-analysis-based-on-the-traumaregister-dgu%C3%A2
#11
J Bayer, R Lefering, S Reinhardt, J Kühle, N P Südkamp, T Hammer
BACKGROUND: Major trauma is associated with chest injuries in nearly 50% of multiple injuries. Thoracic trauma is a relevant source of comorbidity throughout the period of multiply-injured patient care and may require swift and well-thought-out interventions in order to avert a deleterious outcome. In this epidemiological study we seek to characterize groups of different thoracic trauma severity in severely injured patients and identify related differences in prehospital and early clinical management...
February 2, 2017: Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine
https://www.readbyqxmd.com/read/28147294/identifying-anthropogenic-anomalies-in-air-surface-and-groundwater-temperatures-in-germany
#12
Susanne A Benz, Peter Bayer, Philipp Blum
Human activity directly influences ambient air, surface and groundwater temperatures. The most prominent phenomenon is the urban heat island effect, which has been investigated particularly in large and densely populated cities. This study explores the anthropogenic impact on the thermal regime not only in selected urban areas, but on a countrywide scale for mean annual temperature datasets in Germany in three different compartments: measured surface air temperature, measured groundwater temperature, and satellite-derived land surface temperature...
January 29, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28147268/autonomous-camkii-activity-as-a-drug-target-for-histological-and-functional-neuroprotection-after-resuscitation-from-cardiac-arrest
#13
Guiying Deng, James E Orfila, Robert M Dietz, Myriam Moreno-Garcia, Krista M Rodgers, Steve J Coultrap, Nidia Quillinan, Richard J Traystman, K Ulrich Bayer, Paco S Herson
The Ca(2+)/calmodulin-dependent protein kinase II (CaMKII) is a major mediator of physiological glutamate signaling, but its role in pathological glutamate signaling (excitotoxicity) remains less clear, with indications for both neuro-toxic and neuro-protective functions. Here, the role of CaMKII in ischemic injury is assessed utilizing our mouse model of cardiac arrest and cardiopulmonary resuscitation (CA/CPR). CaMKII inhibition (with tatCN21 or tatCN19o) at clinically relevant time points (30 min after resuscitation) greatly reduces neuronal injury...
January 31, 2017: Cell Reports
https://www.readbyqxmd.com/read/28143626/cognition-and-adaptive-functioning-in-older-people-attending-drug-and-alcohol-services
#14
L A Monds, N J Ridley, C Rivas, A Withall, B Draper, N Lintzeris
BACKGROUND: Substance use disorders in older adults are expected to increase dramatically in the coming years. Given the increased susceptibility to cognitive deficits in older substance users (defined here as aged 50+ years due to the accelerated health decline observed in this population), it is important to consider the functional correlates of cognitive impairment in these older adults. This study details the cognitive status of older individuals attending outpatient drug and alcohol (D&A) treatment services and seeks to determine of the association of cognitive impairment to self-reported daily functioning...
February 1, 2017: International Psychogeriatrics
https://www.readbyqxmd.com/read/28132097/membrane-traversing-mechanism-of-thyroid-hormone-transport-by-monocarboxylate-transporter-8
#15
Jonas Protze, Doreen Braun, Katrin Manuela Hinz, Dorothea Bayer-Kusch, Ulrich Schweizer, Gerd Krause
Monocarboxylate transporter 8 (MCT8) mediates thyroid hormone (TH) transport across the plasma membrane in many cell types. In order to better understand its mechanism, we have generated three new MCT8 homology models based on sugar transporters XylE in the intracellular opened (PDB ID: 4aj4) and the extracellular partly occluded (PDB ID: 4gby) conformations as well as FucP (PDB ID: 3o7q) and GLUT3 (PDB ID: 4zwc) in the fully extracellular opened conformation. T3-docking studies from both sides revealed interactions with His192, His415, Arg445 and Asp498 as previously identified...
January 28, 2017: Cellular and Molecular Life Sciences: CMLS
https://www.readbyqxmd.com/read/28130434/selective-progesterone-receptor-modulator-sprm-ulipristal-acetate-upa-and-its-effects-on-the-human-endometrium
#16
L H R Whitaker, A A Murray, R Matthews, G Shaw, A R W Williams, P T K Saunders, H O D Critchley
STUDY QUESTION: What is the impact of administration of the selective progesterone receptor modulator (SPRM), ulipristal acetate (UPA) on the endometrium of women with fibroids? SUMMARY ANSWER: UPA administration altered expression of sex-steroid receptors and progesterone-regulated genes and was associated with low levels of glandular and stromal cell proliferation. WHAT IS KNOWN ALREADY: Administration of all SPRM class members results in PAEC (progesterone receptor modulator associated endometrial changes)...
January 26, 2017: Human Reproduction
https://www.readbyqxmd.com/read/28129056/motivational-salience-modulates-early-visual-cortex-responses-across-task-sets
#17
Valentina Rossi, Naomi Vanlessen, Mareike Bayer, Annika Grass, Gilles Pourtois, Annekathrin Schacht
Motivationally relevant stimuli benefit from strengthened sensory processing. It is unclear, however, if motivational value of positive and negative valence has similar or dissociable effects on early visual processing. Moreover, whether these perceptual effects are task-specific, stimulus-specific, or more generally feature-based is unknown. In this study, we compared the effects of positive and negative motivational value on early sensory processing using ERPs. We tested the extent to which these effects could generalize to new task contexts and to stimuli sharing common features with the motivationally significant ones...
January 27, 2017: Journal of Cognitive Neuroscience
https://www.readbyqxmd.com/read/28125438/quantification-and-assessment-of-the-chemical-form-of-residual-gadolinium-in-the-brain-after-repeated-administration-of-gadolinium-based-contrast-agents-comparative-study-in-rats
#18
Thomas Frenzel, Chirag Apte, Gregor Jost, Laura Schöckel, Jessica Lohrke, Hubertus Pietsch
OBJECTIVE: Multiple clinical and preclinical studies have reported a signal intensity increase and the presence of gadolinium (Gd) in the brain after repeated administration of Gd-based contrast agents (GBCAs). This bioanalytical study in rat brain tissue was initiated to investigate whether the residual Gd is present as intact GBCA or in other chemical forms by using tissue fractionation and chromatography. MATERIALS AND METHODS: Rats were divided randomly in 6 groups of 10 animals each...
January 25, 2017: Investigative Radiology
https://www.readbyqxmd.com/read/28125362/duration-of-treatment-in-prostate-cancer-patients-treated-with-abiraterone-acetate-or-enzalutamide
#19
Dominic Pilon, Ajay S Behl, Lorie A Ellis, Bruno Emond, Patrick Lefebvre, Nancy A Dawson
BACKGROUND: Abiraterone acetate (AA) and enzalutamide (ENZ) are oral therapies offering survival benefit to metastatic castration-resistant prostate cancer (mCRPC) patients. Despite the availability of multiple treatment options for mCRPC, there is a lack of information on the effect that being initiated on AA or ENZ has on the combined prostate cancer treatment duration. OBJECTIVE: To compare the combined duration of prostate cancer treatments of patients initiated on AA with that of patients initiated on ENZ...
February 2017: Journal of Managed Care & Specialty Pharmacy
https://www.readbyqxmd.com/read/28120188/phenotypic-and-genotypic-correlates-of-daptomycin-resistant-methicillin-susceptible-staphylococcus-aureus-clinical-isolates
#20
Kyoung-Mi Kang, Nagendra N Mishra, Kun Taek Park, Gi-Yong Lee, Yong Ho Park, Arnold S Bayer, Soo-Jin Yang
Daptomycin (DAP) has potent activity in vitro and in vivo against both methicillin-susceptible Staphylococcus aureus (MSSA) and methicillin-resistant S. aureus (MRSA) strains. DAP-resistance (DAP-R) in S. aureus has been mainly observed in MRSA strains, and has been linked to single nucleotide polymorphisms (SNPs) within the mprF gene leading to altered cell membrane (CM) phospholipid (PL) profiles, enhanced positive surface charge, and changes in CM fluidity. The current study was designed to delineate whether these same genotypic and phenotypic perturbations are demonstrated in clinically-derived DAP-R MSSA strains...
February 2017: Journal of Microbiology / the Microbiological Society of Korea
keyword
keyword
87650
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"