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Takaaki Shiratori, Keisuke Kasai, Nobukazu Yoshikawa
We propose a color-image reconstruction method for two-wavelength digital holography using generalized phase-shifting digital holography (GPSDH). In this method, color interference fringes are captured by a digital camera with a Bayer array color filter, and phase shifting is simultaneously performed for all wavelengths. Color interference fringes are separated into three monochromatic interference fringes using a color-separation method that suppresses the color-filter crosstalk. The object wave is extracted from each monochromatic interference fringe using GPSDH, which prevents problems due to the phase shift wavelength dependence...
August 10, 2017: Applied Optics
María Nieves Cabezas-Palacios, Antonio Jiménez-Caraballo, Sara Tato-Varela, Alicia Sánchez-Sánchez, Carlos Romero-Díaz, Antonio Carrasco-Gallego, Ignacio Zapardiel-Gutiérrez
The aim of this study was to understand the potential complications of the Essure(®) device as well as the factors influencing its onset and patient satisfaction. We present a 9-year descriptive prospective study that included 1068 patients. The device was placed in 1056 of them (98.8%); 894 had no pain or mild pain during the insertion and only 12 patients experienced pain greater than menstrual pain. The proportion of patients without pain was greater in the group that took NSAIDs or NSAIDs and BZD and the unmedicated group had the highest rate of severe pain (p = ...
October 19, 2017: Journal of Obstetrics and Gynaecology: the Journal of the Institute of Obstetrics and Gynaecology
N Nabieva, S Kellner, T Fehm, L Häberle, J de Waal, M Rezai, B Baier, G Baake, H-C Kolberg, M Guggenberger, M Warm, N Harbeck, R Wuerstlein, J-U Deuker, P Dall, B Richter, G Wachsmann, C Brucker, J W Siebers, N Fersis, T Kuhn, C Wolf, H-W Vollert, G-P Breitbach, W Janni, R Landthaler, A Kohls, D Rezek, T Noesselt, G Fischer, S Henschen, T Praetz, V Heyl, T Kühn, T Krauss, C Thomssen, A Hohn, H Tesch, C Mundhenke, A Hein, C Rauh, C M Bayer, A Jacob, K Schmidt, E Belleville, S Y Brucker, S Kümmel, M W Beckmann, D Wallwiener, P Hadji, P A Fasching
Background: Patients' compliance and persistence with endocrine treatment has a significant effect on the prognosis in early breast cancer (EBC). The purpose of this analysis was to identify possible reasons for non-persistence, defined as premature cessation of therapy, on the basis of patient and tumor characteristics in individuals receiving adjuvant treatment with letrozole. Patients and methods: The EvAluate-TM Study is a prospective, multicenter, noninterventional study in which treatment with the aromatase inhibitor letrozole was evaluated in postmenopausal women with hormone receptor-positive EBC in the early therapy phase...
October 10, 2017: Annals of Oncology: Official Journal of the European Society for Medical Oncology
Anja Matena, Edisa Rehic, Dana Hönig, Bianca Kamba, Peter Bayer
Parvulins belong to the family of peptidyl-prolyl cis/trans isomerases (PPIases) assisting in protein folding and in regulating the function of a broad variety of proteins in all branches of life. The human representatives Pin1 and Par14/17 are directly involved in processes influencing cellular maintenance and cell fate decisions such as cell-cycle progression, metabolic pathways and ribosome biogenesis. This review on human parvulins summarizes the current knowledge of these enzymes and intends to oppose the well-studied Pin1 to its less well-examined homolog human Par14/17 with respect to structure, catalytic and cellular function...
October 26, 2017: Biological Chemistry
Thierry Calvez, Hervé Chambost, Roseline d'Oiron, Vincent Dalibard, Virginie Demiguel, Alexandra Doncarli, Yves Gruel, Yoann Huguenin, Patrick Lutz, Chantal Rothschild, Christine Vinciguerra, Jenny Goudemand
Around one third of boys with severe hemophilia A develop inhibitors (neutralizing antibodies) against their therapeutic factor VIII product. This adverse effect may result in more life-threatening bleeding, disability, impaired quality of life, and costly care. We compared the inhibitor incidence in boys treated with the three factor VIII products most used in France: one plasma-derived (Factane) and two recombinant products (Advate and Kogenate Bayer). A previously untreated patient cohort was created in 1994 to investigate risk factors for inhibitor development...
October 12, 2017: Haematologica
Kaan Gündüz, Gökçen Çöndü, Carol L Shields
The authors report on two patients with bilateral acute exudative polymorphous paraneoplastic vitelliform maculopathy (AEPPVM) treated with intravitreal aflibercept (Eylea; Regeneron, Tarrytown, NY [marketed locally in Turkey by Bayer]). Underlying malignancy had been treated in each case, including breast carcinoma in one case and colon carcinoma in the other case. A macular vitelliform lesion was noted in the right eye and atrophic retinal pigment epithelial (RPE) changes were noted in the left eye of each case...
October 1, 2017: Ophthalmic Surgery, Lasers & Imaging Retina
Thomas J Dilworth, Warren E Rose, George Sakoulas, Arnold S Bayer
No abstract text is available yet for this article.
July 29, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
Eric Wenzler, Fei Wang, Debra A Goff, Beth Prier, John Mellett, Julie E Mangino, Karri A Bauer
No abstract text is available yet for this article.
July 29, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
Maria Summa, Debora Russo, Ilaria Penna, Natasha Margaroli, Ilker S Bayer, Tiziano Bandiera, Athanassia Athanassiou, Rosalia Bertorelli
In the last few years, there has been an increasing tendency to use natural polymers for the fabrication of dressings for wound and burn management. Among them, alginate, a polysaccharide extracted primarily from marine algae, exhibits attractive properties being non-toxic, hydrophilic and biodegradable. The aim of this study was to characterize the in vitro biocompatibility and the efficacy of a composite polymeric material based on sodium alginate (NaAlg) and povidone iodine (PVPI) complex in a mouse model of wound healing...
October 7, 2017: European Journal of Pharmaceutics and Biopharmaceutics
José A Heredia-Guerrero, Antonio Heredia, Eva Domínguez, Roberto Cingolani, Ilker S Bayer, Athanassia Athanassiou, José J Benítez
Cutin is the main component of plant cuticles constituting the framework that supports the rest of the cuticle components. This biopolymer is composed of esterified bi- and trifunctional fatty acids. Despite its ubiquity in terrestrial plants, it has been underutilized as raw material due to its insolubility and lack of melting point. However, in recent years, a few technologies have been developed to obtain cutin monomers from several agro-wastes at an industrial scale. This review is focused on the description of cutin properties, biodegradability, chemical composition, processability, abundance, and the state of art of the fabrication of cutin-based materials in order to evaluate whether this biopolymer can be considered a source for the production of renewable materials...
August 8, 2017: Journal of Experimental Botany
William J Nicolas, Magali S Grison, Emmanuelle M Bayer
Plasmodesmata (PD) are a hallmark of the plant kingdom and a cornerstone of plant biology and physiology, forming the conduits for the cell-to-cell transfer of proteins, RNA and various metabolites, including hormones. They connect the cytosols and endomembranes of cells, which allows enhanced cell-to-cell communication and synchronization. Because of their unique position as intercellular gateways, they are at the frontline of plant defence and signalling and constitute the battleground for virus replication and spreading...
September 7, 2017: Journal of Experimental Botany
Tzeyu L Michaud, Wen You, Kathryn E Wilson, Dejun Su, Todd J McGuire, Fabio A Almeida, Amy L Bayer, Paul A Estabrooks
This study assessed the lifetime health and economic consequences of an efficacious scalable community weight loss program for overweight and obese adults. We applied a state-transition Markov model to project lifetime economic outcome (US dollar) and the degree of disease averted as a result of a weight loss intervention, compared with no intervention, from a payer perspective. Effect sizes of the intervention on weight loss, by sex, race and ethnicity, and body mass index (BMI) of participants, were derived from a 12-month community program...
October 5, 2017: Preventive Medicine
Anna Torrens-Burton, Nasreen Basoudan, Antony J Bayer, Andrea Tales
This study examines the relationships between two measures of information processing speed associated with executive function (Trail Making Test and a computer-based visual search test), the perceived difficulty of the tasks, and perceived memory function (measured by the Memory Functioning Questionnaire) in older adults (aged 50+ y) with normal general health, cognition (Montreal Cognitive Assessment score of 26+), and mood. The participants were recruited from the community rather than through clinical services, and none had ever sought or received help from a health professional for a memory complaint or mental health problem...
October 3, 2017: Journal of Alzheimer's Disease: JAD
Thomas Wiesinger, Thomas Bayer, Sofia Milker, Marko D Mihovilovic, Florian Rudroff
We investigated a synthetic cascade for the transformation of primary alcohols into polyhydroxylated compounds in Escherichia coli by the in situ preparation of cytotoxic aldehyde intermediates and subsequent aldolase mediated C-C bond formation. An enzymatic toolbox consisting of the alcohol dehydrogenase (ADH) AlkJ from Pseudomonas putida and the dihydroxyacetone/hydroxyacetone (DHA/HA) accepting aldolase variant Fsa1-A129S was applied. Pathway optimization was performed on genetic and process level. Three different arrangements of the alkJ and the fsa1-A129S genes in operon, monocistronic, and pseudo-operon configuration were tested...
October 5, 2017: Chembiochem: a European Journal of Chemical Biology
Oliver Wirths, Susanne Walter, Inga Kraus, Hans W Klafki, Martina Stazi, Timo J Oberstein, Jorge Ghiso, Jens Wiltfang, Thomas A Bayer, Sascha Weggen
BACKGROUND: The deposition of neurotoxic amyloid-β (Aβ) peptides in plaques in the brain parenchyma and in cerebral blood vessels is considered to be a key event in Alzheimer's disease (AD) pathogenesis. Although the presence and impact of full-length Aβ peptides such as Aβ1-40 and Aβ1-42 have been analyzed extensively, the deposition of N-terminally truncated Aβ peptide species has received much less attention, largely because of the lack of specific antibodies. METHODS: This paper describes the generation and characterization of novel antibodies selective for Aβ4-x peptides and provides immunohistochemical evidence of Aβ4-x in the human brain and its distribution in the APP/PS1KI and 5XFAD transgenic mouse models...
October 4, 2017: Alzheimer's Research & Therapy
Mary Kathryn Sewell-Loftin, Samantha Van Hove Bayer, Elizabeth Crist, Taylor Hughes, Sofia M Joison, Gregory D Longmore, Steven C George
The role of cancer-associated fibroblasts (CAFs) as regulators of tumor progression, specifically vascular growth, has only recently been described. CAFs are thought to be more mechanically active but how this trait may alter the tumor microenvironment is poorly understood. We hypothesized that enhanced mechanical activity of CAFs, as regulated by the Rho/ROCK pathway, contributes to increased blood vessel growth. Using a 3D in vitro tissue model of vasculogenesis, we observed increased vascularization in the presence of breast cancer CAFs compared to normal breast fibroblasts...
October 3, 2017: Scientific Reports
Natalie Wiedemar, Fabrice E Graf, Michaela Zwyer, Emiliana Ndomba, Christina Kunz Renggli, Monica Cal, Remo S Schmidt, Tanja Wenzler, Pascal Mäser
Suramin is one of the first drugs developed in a medicinal chemistry program (Bayer, 1916), and it is still the treatment of choice for the hemolymphatic stage of African sleeping sickness caused by Trypanosoma brucei rhodesiense. Cellular uptake of suramin occurs by endocytosis, and reverse genetic studies with T. b. brucei have linked downregulation of the endocytic pathway to suramin resistance. Here we show that forward selection for suramin resistance in T. brucei spp. cultures is fast, highly reproducible, and linked to antigenic variation...
September 30, 2017: Molecular Microbiology
Mark E Looseley, Micha Bayer, Hazel Bull, Luke Ramsay, William Thomas, Allan Booth, Carla De La Fuente Canto, Jenny Morris, Pete E Hedley, Joanne Russell
Diastatic Power (DP) is an important quality trait for malt used in adjunct brewing and distilling. Substantial genetic variation for DP exists within UK elite barley cultivars, but breeding progress has been slow due to the limited demand, compared to the overall barley market, and difficulties in assessing DP. Estimates of DP (taken from recommended and national list trials between 1994 and 2012) from a collection of UK elite winter and spring varieties were used to identify contrasting sets of high and low DP varieties...
2017: Frontiers in Plant Science
Monika L Bayer, S Peter Magnusson, Michael Kjaer
New England Journal of Medicine, Volume 377, Issue 13, Page 1300-1301, September 2017.
September 28, 2017: New England Journal of Medicine
Jacob Stewart, Stephanie Bayers, Travis Vandergriff
Neutrophilic panniculitis is a relatively rare condition, characterized by predominantly neutrophilic inflammation in the subcutaneous fat. Rarely, neutrophilic panniculitis may be induced by chemotherapeutics or targeted molecular therapies, including the Bruton tyrosine kinase inhibitor ibrutinib. Previously reported cases of ibrutinib-induced panniculitis were suppressed with sustained low-dose steroid therapy while continuing ibrutinib therapy. To our knowledge, self-limiting panniculitis during ibrutinib therapy has not yet been described...
September 20, 2017: American Journal of Dermatopathology
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