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https://www.readbyqxmd.com/read/29227466/morbidity-and-mortality-of-a-cohort-of-peruvian-hiv-infected-children-2003-2012
#1
Amira N Baker, Angela M Bayer, Rolando M Viani, Lenka Kolevic, Myung-Shin Sim, Jaime G Deville
BACKGROUND: Data on pediatric HIV in Peru is limited. The National Institute of Child Health (Instituto Nacional de Salud del Niño: INSN) cares for the most HIV-infected children under age 18 in the country. We describe the outcomes of children seen at INSN's HIV clinic over the 10 years when antiretroviral therapy (ART) and prevention of mother-to-child transmission (PMTCT) interventions became available in 2004. METHODS: We conducted a retrospective review of INSN HIV clinic patients between 2003-2012...
December 8, 2017: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/29226227/online-platform-as-a-tool-to-support-postgraduate-training-in-general-practice-a-case-report
#2
Lorena Dini, Claire Galanski, Susanne Döpfmer, Sabine Gehrke-Beck, Gudrun Bayer, Martin Boeckle, Isabel Micheel, Jasminko Novak, Christoph Heintze
Objective: Physicians in postgraduate training (PPT) in General Practice (GP) typically have very little interaction with their peers, as there is usually only one resident physician working in their respective department or GP office at a given time. Therefore, the online platform KOLEGEA, presented here, aims to support postgraduate training in general practice (PT in GP) in Germany through virtual interaction. Methodology: In 2012, the interdisciplinary research project KOLEGEA set up an online platform that any physicians in PT in GP can use for free after registration with their unitary continuous education number (Einheitliche Fortbildungsnummer, EFN)...
2017: GMS Journal for Medical Education
https://www.readbyqxmd.com/read/29220180/securamine-derivatives-from-the-arctic-bryozoan-securiflustra-securifrons
#3
Kine Ø Hansen, Johan Isaksson, Annette Bayer, Jostein A Johansen, Jeanette H Andersen, Espen Hansen
Bryozoans belonging to the Flustridae family have proven to be a rich source of structurally unique secondary metabolites. As part of our continuing search for bioactive secondary metabolites from Arctic marine invertebrates, the organic extract of Securiflustra securifrons was examined. This resulted in the isolation of three new halogenated, hexacyclic indole-imidazole alkaloids, securamines H-J (1-3), together with the previously reported compounds securamines C (4) and E (5). The structures of the new compounds were elucidated by spectroscopic methods including 1D and 2D NMR and analysis of HRMS data...
December 8, 2017: Journal of Natural Products
https://www.readbyqxmd.com/read/29218028/the-folate-cycle-as-a-cause-of-natural-killer-cell-dysfunction-and-viral-etiology-in-type-1-diabetes
#4
Allison L Bayer, Christopher A Fraker
The folate pathway is critical to proper cellular function and metabolism. It is responsible for multiple functions, including energy (ATP) production, methylation reactions for DNA and protein synthesis and the production of immunomodulatory molecules, inosine and adenosine. These play an important role in immune signaling and cytotoxicity. Herein, we hypothesize that defects in the folate pathway in genetically susceptible individuals could lead to immune dysfunction, permissive environments for chronic cyclical latent/lytic viral infection, and, ultimately, the development of unchecked autoimmune responses to infected tissue, in this case islet beta cells...
2017: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/29216806/an-industry-update-the-latest-developments-in-therapeutic-delivery
#5
Iain Simpson
This industry update covers the period from 1 September through 30 September 2017, and is based on information sourced from company press releases, scientific literature, patents and various news websites. The month saw the US FDA approve three new molecular entities, Aliqopa (copanlisib dihydrochloride) (Bayer Healthcare); Solosec (secnidazole) (Symbiomix Therapeutics) and Verzenio (abemaciclib) (Eli Lilly and Co). Intarcia Therapeutics Inc. has its application for approval of a novel drug device combination of exenatide for the treatment of diabetes rejected by FDA but said that it will work to address the concerns and refile the application...
January 2018: Therapeutic Delivery
https://www.readbyqxmd.com/read/29216050/spatial-intensity-profiling-of-elastic-and-inelastic-scattering-in-isotropic-and-anisotropic-liquids-by-immersion-of-a-spherical-silicon-photocell
#6
Muhammad Hamza Humayun, Syed Sultan Shah Bukhari, Muhammad Zakwan, Mustafa Mert Bayer, Ulaş Sabahattin Gökay, Ali Serpengüzel, Kenichi Taira, Etsuji Omura, Josuke Nakata
The transverse spatial intensity distribution of elastic and inelastic light scattering in passive and active as well as weak and strong scattering liquid media has been studied by using Sphelar One p-n junction silicon spherical photocells. We immersed a Sphelar One in these scattering solutions and measured the photoconductive response in reverse biased photodiode (PD) configuration. The passive weak scattering medium was pure ethanol (EtOH), whereas the passive strong scattering medium was 5CB nematic liquid crystal (NLC)...
December 1, 2017: Applied Optics
https://www.readbyqxmd.com/read/29209415/undefined-cellulase-formulations-hinder-scientific-reproducibility
#7
EDITORIAL
Michael E Himmel, Charles A Abbas, John O Baker, Edward A Bayer, Yannick J Bomble, Roman Brunecky, Xiaowen Chen, Claus Felby, Tina Jeoh, Rajeev Kumar, Barry V McCleary, Brett I Pletschke, Melvin P Tucker, Charles E Wyman, Stephen R Decker
In the shadow of a burgeoning biomass-to-fuels industry, biological conversion of lignocellulose to fermentable sugars in a cost-effective manner is key to the success of second-generation and advanced biofuel production. For the effective comparison of one cellulase preparation to another, cellulase assays are typically carried out with one or more engineered cellulase formulations or natural exoproteomes of known performance serving as positive controls. When these formulations have unknown composition, as is the case with several widely used commercial products, it becomes impossible to compare or reproduce work done today to work done in the future, where, for example, such preparations may not be available...
2017: Biotechnology for Biofuels
https://www.readbyqxmd.com/read/29205771/homoeologous-exchange-is-a-major-cause-of-gene-presence-absence-variation-in-the-amphidiploid-brassica-napus
#8
Bhavna Hurgobin, Agnieszka A Golicz, Philipp E Bayer, Chon-Kit Kenneth Chan, Soodeh Tirnaz, Aria Dolatabadian, Sarah V Schiessl, Birgit Samans, Juan D Montenegro, Isobel A P Parkin, J Chris Pires, Boulos Chalhoub, Graham J King, Rod Snowdon, Jacqueline Batley, David Edwards
Homoeologous exchanges (HEs) have been shown to generate novel gene combinations and phenotypes in a range of polyploid species. Gene presence/absence variation (PAV) is also a major contributor to genetic diversity. In the present study we show that there is an association between these two events, particularly in recent Brassica napus synthetic accessions, and that these represent a novel source of genetic diversity, which can be captured for the improvement of this important crop species. By assembling the pangenome of B...
December 4, 2017: Plant Biotechnology Journal
https://www.readbyqxmd.com/read/29204964/a-randomized-double-blind-placebo-controlled-cross-over-trial-vestparoxy-of-the-treatment-of-vestibular-paroxysmia-with-oxcarbazepine
#9
Otmar Bayer, Tatiana Brémová, Michael Strupp, Katharina Hüfner
OBJECTIVE: Vestibular paroxysmia (VP) is characterized by short, often oligosymptomatic attacks of vertigo which occur spontaneously or are sometimes provoked by turning the head. Despite the description of the disease almost 40 years ago (first termed "disabling positional vertigo"), no controlled treatment trial has been published to date. The Vestparoxy trial was designed as a randomized, placebo-controlled, double-blind cross-over trial to examine the therapeutic effect of oxcarbazepine (OXA) in patients with definite or probable VP...
November 27, 2017: Journal of Neurology
https://www.readbyqxmd.com/read/29202049/the-odyssey-of-linking-to-and-staying-in-hiv-care-among-male-sex-workers-in-peru
#10
Angela M Bayer, Chanelle M Díaz, Marina Chiappe, Amira N Baker, Miguel S Egoavil, José E Pérez-Lu, Pamina M Gorbach, Patricia J García
Background: In Peru, there is little information about the HIV care continuum. Therefore, we conducted a study to describe the HIV care continuum among male sex workers (MSWs) in Lima. Methods: We applied close-ended surveys with 209 MSWs about their engagement in the HIV care continuum and open-ended surveys with 34 MSWs who are people living with HIV (PLHIV) to explore their linkage to and retention in HIV care. Results: Of 209 MSWs, only 71% (n=148) reported a lifetime HIV test and 56% (n=116) of all MSWs received confirmatory HIV test results...
January 2017: Journal of HIV and AIDS
https://www.readbyqxmd.com/read/29201648/cultured-fish-epithelial-cells-are-a-source-of-alarm-substance
#11
Heather A Hintz, Courtney Weihing, Rachel Bayer, David Lonzarich, Winnifred Bryant
In various species of fishes, the importance of visual cues in the determination of environmental threat and subsequent predator avoidance is clear. Chemical cues also play an essential role facilitating predator avoidance. Among fish in the superorder Ostariophysi, club cells in the epidermis produce an alarm substance. Damage to the skin during a predation event releases an alarm substance (AS), which diffuses through the water column and binds to olfactory receptors of conspecifics. Fish then engage in a number of anti-predator behaviors that may include darting, schooling, or hiding...
2017: MethodsX
https://www.readbyqxmd.com/read/29196604/camkii-regulates-the-de-palmitoylation-and-synaptic-removal-of-akap79-150-to-mediate-structural-ltd
#12
Kevin M Woolfrey, Heather O'Leary, Dayton J Goodell, Holly R Robertson, Eric A Horne, Steven J Coultrap, Mark L Dell'Acqua, K Ulrich Bayer
Both long-term potentiation (LTP) and depression (LTD) of excitatory synapse strength require the Ca2+/calmodulin (CaM)-dependent protein kinase II (CaMKII) and its autonomous activity generated by T286 autophosphorylation. Additionally, LTP and LTD are correlated with dendritic spine enlargement and shrinkage that are accompanied by the synaptic accumulation or removal, respectively, of the AMPA-receptor regulatory scaffold protein A-kinase anchoring protein (AKAP) 79/150. We show here that the spine shrinkage associated with LTD indeed requires synaptic AKAP79/150 removal, which in turn requires CaMKII activity...
December 1, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/29194407/adaptive-residual-interpolation-for-color-and-multispectral-image-demosaicking
#13
Yusuke Monno, Daisuke Kiku, Masayuki Tanaka, Masatoshi Okutomi
Color image demosaicking for the Bayer color filter array is an essential image processing operation for acquiring high-quality color images. Recently, residual interpolation (RI)-based algorithms have demonstrated superior demosaicking performance over conventional color difference interpolation-based algorithms. In this paper, we propose adaptive residual interpolation (ARI) that improves existing RI-based algorithms by adaptively combining two RI-based algorithms and selecting a suitable iteration number at each pixel...
December 1, 2017: Sensors
https://www.readbyqxmd.com/read/29181587/diagnostic-accuracy-of-low-and-high-tube-voltage-coronary-ct-angiography-using-an-x-ray-tube-potential-tailored-contrast-medium-injection-protocol
#14
Moritz H Albrecht, John W Nance, U Joseph Schoepf, Brian E Jacobs, Richard R Bayer, Sheldon E Litwin, Michael A Reynolds, Katharina Otani, Stefanie Mangold, Akos Varga-Szemes, Domenico De Santis, Marwen Eid, Georg Apfaltrer, Christian Tesche, Markus Goeller, Thomas J Vogl, Carlo N De Cecco
OBJECTIVES: To compare the diagnostic accuracy between low-kilovolt peak (kVp) (≤ 100) and high-kVp (> 100) third-generation dual-source coronary CT angiography (CCTA) using a kVp-tailored contrast media injection protocol. METHODS: One hundred twenty patients (mean age = 62.6 years, BMI = 29.0 kg/m2) who underwent catheter angiography and CCTA with automated kVp selection were separated into two cohorts (each n = 60, mean kVp = 84 and 117). Contrast media dose was tailored to the kVp level: 70 = 40 ml, 80 = 50 ml, 90 = 60 ml, 100 = 70 ml, 110 = 80 ml, and 120 = 90 ml...
November 27, 2017: European Radiology
https://www.readbyqxmd.com/read/29176607/gate-tunable-large-magnetoresistance-in-an-all-semiconductor-spin-valve-device
#15
M Oltscher, F Eberle, T Kuczmik, A Bayer, D Schuh, D Bougeard, M Ciorga, D Weiss
A large spin-dependent and electric field-tunable magnetoresistance of a two-dimensional electron system is a key ingredient for the realization of many novel concepts for spin-based electronic devices. The low magnetoresistance observed during the last few decades in devices with lateral semiconducting transport channels between ferromagnetic source and drain contacts has been the main obstacle for realizing spin field effect transistor proposals. Here, we show both a large two-terminal magnetoresistance in a lateral spin valve device with a two-dimensional channel, with up to 80% resistance change, and tunability of the magnetoresistance by an electric gate...
November 27, 2017: Nature Communications
https://www.readbyqxmd.com/read/29173546/season-long-control-of-flea-and-tick-infestations-in-a-population-of-cats-in-the-aeolian-archipelago-using-a-collar-containing-10-imidacloprid-and-4-5-flumethrin
#16
Domenico Otranto, Filipe Dantas-Torres, Ettore Napoli, Fabrizio Solari Basano, Katrin Deuster, Matthias Pollmeier, Gioia Capelli, Emanuele Brianti
Cats that have outdoor access are highly exposed to ticks, fleas, mites and flying insects, though the risk to become infested by arthropods is less perceived in cats than in dogs. This has resulted in fewer treatment and prevention options being available for cats than for dogs. A collar containing a combination of 10% imidacloprid and 4.5% flumethrin (Seresto®, Bayer Animal Health) is available for cats and licensed with claims against ticks and fleas for 7-8 months. Following the assessment of the efficacy of the collar against Leishmania infantum infection in privately owned cats living in the Aeolian archipelago, herein we report the efficacy of the collar in the treatment and prevention of tick and flea infestations in the same population of cats over a period of one year of observation...
December 15, 2017: Veterinary Parasitology
https://www.readbyqxmd.com/read/29166244/precision-medicine-from-a-public-health-perspective
#17
Ramya Ramaswami, Ronald Bayer, Sandro Galea
Over the past decade, precision medicine (PM) approaches have received significant investment to create new therapies, learn more about disease processes, and potentially prevent diseases before they arise. However, in many ways, PM investments may come at the expense of existing public health measures that could have a greater impact on population health. As we tackle burgeoning public health concerns, such as obesity, and chronic diseases, such as cancer, it is not clear whether PM is aligned with public health or in conflict with its goals...
November 20, 2017: Annual Review of Public Health
https://www.readbyqxmd.com/read/29166023/rhodium-catalyzed-synthesis-of-sulfur-ylides-via-in-situ-generated-iodonium-ylides
#18
Janakiram Vaitla, Kathrin H Hopmann, Annette Bayer
A convenient strategy for the synthesis of sulfur ylides via rhodium-catalyzed coupling of in situ generated iodonium ylides with sulfides or sulfoxides has been developed. A wide range of sulfur ylides were obtained in moderate to good yields from inexpensive sulfur compounds and active methylene compounds with a short reaction time (MW, 5-10 min) or 12-16 h at rt. Furthermore, these sulfoxonium ylides were used as novel acceptor/acceptor carbenes for N-H insertion reactions.
November 22, 2017: Organic Letters
https://www.readbyqxmd.com/read/29160075/electron-and-hole-g-factors-and-spin-dynamics-of-negatively-charged-excitons-in-cdse-cds-colloidal-nanoplatelets-with-thick-shells
#19
Elena V Shornikova, Louis Biadala, Dmitri R Yakovlev, Donghai Feng, Victor F Sapega, Nathan Flipo, Aleksandr A Golovatenko, Marina A Semina, Anna V Rodina, Anatolie Mitioglu, Mariana V Ballottin, Peter C M Christianen, Yuri G Kusrayev, Michel Nasilowski, Benoit Dubertret, Manfred Bayer
We address spin properties and spin dynamics of carriers and charged excitons in CdSe/CdS colloidal nanoplatelets with thick shells. Magneto-optical studies are performed by time-resolved and polarization-resolved photoluminescence, spin-flip Raman scattering and picosecond pump-probe Faraday rotation in magnetic fields up to 30 T. We show that at low temperatures the nanoplatelets are negatively charged so that their photoluminescence is dominated by radiative recombination of negatively charged excitons (trions)...
November 21, 2017: Nano Letters
https://www.readbyqxmd.com/read/29159997/sporulation-capability-and-amylosome-conservation-among-diverse-human-colonic-and-rumen-isolates-of-the-keystone-starch-degrader-ruminococcus-bromii
#20
Indrani Mukhopadhya, Sarah Morais, Jenny Laverde-Gomez, Paul O Sheridan, Alan W Walker, William Kelly, Athol V Klieve, Diane Ouwerkerk, Sylvia H Duncan, Petra Louis, Nicole Koropatkin, Darrell Cockburn, Ryan Kibler, Philip J Cooper, Carlos Sandoval, Emmanuelle Crost, Nathalie Juge, Edward A Bayer, Harry J Flint
Ruminococcus bromii is a dominant member of the human colonic microbiota that plays a 'keystone' role in degrading dietary resistant starch. Recent evidence from one strain has uncovered a unique cell surface 'amylosome' complex that organizes starch-degrading enzymes. New genome analysis presented here reveals further features of this complex and shows remarkable conservation of amylosome components between human colonic strains from three different continents and a R. bromii strain from the rumen of Australian cattle...
November 21, 2017: Environmental Microbiology
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