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https://www.readbyqxmd.com/read/28743126/frontal-cortex-and-hippocampal-%C3%AE-secretase-activating-protein-levels-in-prodromal-alzheimer-disease
#1
Sylvia E Perez, Muhammad Nadeem, Michael H Malek-Ahmadi, Bin He, Elliott J Mufson
BACKGROUND: β-Amyloid (Aβ) is the product of concerted cleavage of the amyloid precursor protein (APP) by β- and γ-secretases. However, the molecular mechanisms that regulate this process are not well understood. Recently, evidence was reported that γ-secretase activating protein (GSAP, 16 kDa), derived from a larger precursor protein (98 kDa), plays a role in Aβ metabolism through a mechanism involving its interaction with both γ-secretase and APP. However, a detailed evaluation of GSAP protein levels and their association with clinical and neuropathological variables are lacking during the clinical progression of Alzheimer disease (AD)...
July 26, 2017: Neuro-degenerative Diseases
https://www.readbyqxmd.com/read/28743116/the-role-of-tumoral-foxp3-on-cell-proliferation-migration-and-invasion-in-gastric-cancer
#2
Lu Zhang, Jianghao Xu, Xuan Zhang, Yi Zhang, Lu Wang, Xiaoxu Huang, Zekuan Xu
BACKGROUND/AIMS: There is little published data on the role of FOXP3 in gastric cancer. METHODS: FOXP3 expression and localization in gastric cancer tissues and cells were examined by immunohistochemistry, RT-PCR, flow cytometry, western blot, and laser confocal microscopy. CCK8, plate clone, wound healing, and transwell insert assays were performed for gastric cancer cells. Potential molecules and signaling pathways were screened using high-throughput transcriptome sequencing...
July 25, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/28743110/clinical-endocrine-and-molecular-genetic-analysis-of-a-large-cohort-of-saudi-arabian-patients-with-laron-syndrome
#3
Abdullah A Al-Ashwal, Afaf Al-Sagheir, Khushnooda Ramzan, Mohammed Al-Owain, Rabab Allam, Alya Qari, Nouf S Al-Numair, Faiqa Imtiaz
BACKGROUND/AIMS: Laron syndrome (LS) is an autosomal recessive disease characterized by marked short stature and very low serum IGF-1 and IGFBP-3 levels. This study assessed the clinical and endocrine features alongside determining the growth hormone receptor gene (GHR) mutation in Saudi Arabian patients with LS in order to establish whether or not a genotype/phenotype correlation is evident in this large cohort. SUBJECTS AND METHODS: A total of 40 Saudi Arabian patients with a suspected diagnosis of LS were recruited and subjected to a full clinical and endocrine investigation together with direct sequencing of the coding regions of the GHR gene...
July 25, 2017: Hormone Research in Pædiatrics
https://www.readbyqxmd.com/read/28743092/polycyclic-aromatic-hydrocarbons-pahs-enrich-their-degrading-genera-and-genes-in-human-impacted-aquatic-environments
#4
Ke Yuan, Baowei Chen, Qing Qing, Shichun Zou, Xiaowei Wang, Tiangang Luan
Bacterial degradation is an important clearance pathway for organic contaminants from highly human-impacted environments. However, it is not fully understood how organic contaminants are selected for degradation by bacteria and genes in aquatic environments. In this study, PAH degrading bacterial genera and PAH-degradation-related genes (PAHDGs) in sediments collected from the Pearl River (PR), the Pearl River Estuary (PRE) and the South China Sea (SCS), among which there were distinct differences in anthropogenic impact, were analyzed using metagenomic approaches...
July 22, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/28743064/health-status-and-mobility-limitations-are-associated-with-residential-and-employment-status-in-schizophrenia-and-bipolar-disorder
#5
M Strassnig, D Cornacchio, P D Harvey, R Kotov, L Fochtmann, E J Bromet
INTRODUCTION: Schizophrenia (SCZ) and bipolar disorder (BP) are linked to multiple impairments in everyday functioning which share cognitive and symptom risk factors. Other risk factors for critical aspects of every day functioning (e.g., gainful employment; residential independence) such as physical health have not been evaluated, despite poor health in SCZ and BP. METHODS: We analyzed 20-year follow-up data from the Suffolk County Mental Health Project cohort of consecutive first admissions with a psychotic disorder to 12 psychiatric facilities in Suffolk County, NY, between September 1989 and December 1995...
July 18, 2017: Journal of Psychiatric Research
https://www.readbyqxmd.com/read/28743061/circulating-ctrp9-levels-are-increased-in-patients-with-newly-diagnosed-type-2-diabetes-and-correlated-with-insulin-resistance
#6
Yanjun Jia, Xiaohe Luo, Ying Ji, Jingwen Xie, Han Jiang, Mao Fu, Xiaoqiang Li
AIMS: C1q/TNF-related protein-9 (CTRP9) is a novel adipokine that has been shown to promote lipid metabolism, enhance insulin sensitivity and protect against cardiovascular disease. However, previous studies in humans have produced controversial results regarding the association between CTRP9 and insulin resistance. The objective of this study was to evaluate the relationships between CTRP9 and insulin resistance in Chinese population. METHODS: Subjects with normal glucose tolerance (NGT, n=108), impaired glucose tolerance (IGT, n=92), and newly diagnosed type 2 diabetes mellitus (nT2DM, n=106) were recruited to determining the circulating CTRP9 and adiponectin levels by enzyme linked immunosorbent assay...
July 8, 2017: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/28743060/glucose-fluctuation-and-the-resultant-endothelial-injury-are-correlated-with-pancreatic-%C3%AE-cell-dysfunction-in-patients-with-coronary-artery-disease
#7
Makoto Murata, Hitoshi Adachi, Shigeru Oshima, Masahiko Kurabayashi
AIMS: We evaluated whether glucose fluctuation (GF) causes vascular endothelial injury and affects glucometabolic factors during lengthy oral glucose tolerance test (OGTT). METHODS: We enrolled consecutive 116 patients with coronary artery disease (CAD) who were performed coronary angiography and 4-h OGTT. Blood samples were collected before and 4h after glucose load to measure endothelial injury factor [von Willebrand factor (vWF) and vWF/a disintegrin-like and metalloproteinase with thrombospondin type-1 motifs 13 (ADAMTS-13) ratio]...
July 8, 2017: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/28743059/altered-connectivity-within-and-between-the-default-mode-central-executive-and-salience-networks-in-obsessive-compulsive-disorder
#8
Jie Fan, Mingtian Zhong, Jun Gan, Wanting Liu, Chaoyang Niu, Haiyan Liao, Hongchun Zhang, Jinyao Yi, Raymond C K Chan, Changlian Tan, Xiongzhao Zhu
BACKGROUND: Default mode network (DMN), central executive network (CEN) and salience network (SN) are the three most important intrinsic networks of the human brain. Recent studies emphasized the importance of the "triple-network model" which illustrated the interactions within and between DMN, CEN and SN in the pathophysiology of psychiatric disorders. However, previous studies of obsessive-compulsive disorder (OCD) just explored the altered connectivity within these networks while neglected the coupling between them...
July 20, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28743045/wind-friction-parametrisation-used-in-emission-models-for-wastewater-treatment-plants-a-critical-review
#9
REVIEW
Ademir A Prata, Jane M Santos, Victoria Timchenko, Neyval C Reis, Richard M Stuetz
Emission models are widely applied tools for estimating atmospheric emissions from wastewater treatment plants (WWTPs). The friction velocity u∗ is a key variable for the modelling of emissions from passive liquid surfaces in WWTPs. This work evaluated different parametrisations of u∗ for passive liquid surfaces at the scale of WWTP units, which present relatively small fetches, based on available wind friction and wave data measured at wind-wave tanks (fetches spanning from approximately 3 to 100 m, and wind speeds from 2 to 17 m s(-1))...
July 17, 2017: Water Research
https://www.readbyqxmd.com/read/28743042/clinical-outcome-and-rehabilitation-of-homeless-mentally-ill-patients-admitted-in-mental-health-institute-of-south-india-know-the-unknown-project
#10
Guru S Gowda, G Gopika, Channaveerachari Naveen Kumar, Narayana Manjunatha, Ravi Yadav, Dwarakanath Srinivas, Bharath Rose Dawn, Suresh Bada Math
OBJECTIVES: Homeless Mentally Ill (HMI) patients represent a unique global problem and pose a challenge in treatment, management and rehabilitation services. There is sparse data on HMI patients in India. The objective of this paper is to study the clinical outcome and rehabilitation of HMI patients. METHODS: We performed a retrospective chart review of 'HMI' patients from 1st January 2002 to 31st December 2015, who were admitted under Department of Psychiatry at National Institute of Mental Health and Neurosciences (NIMHANS), Bangalore, India...
July 4, 2017: Asian Journal of Psychiatry
https://www.readbyqxmd.com/read/28743040/prenatal-exposure-to-organophosphorus-pesticides-and-childhood-neurodevelopmental-phenotypes
#11
Melissa A Furlong, Amy Herring, Jessie P Buckley, Barbara D Goldman, Julie L Daniels, Lawrence S Engel, Mary S Wolff, Jia Chen, Jim Wetmur, Dana Boyd Barr, Stephanie M Engel
Prenatal exposure to organophosphorus pesticides (OPs) has been associated with different neurodevelopmental outcomes across different cohorts. A phenotypic approach may address some of these differences by incorporating information across scales and accounting for the complex correlational structure of neurodevelopmental outcomes. Additionally, Bayesian hierarchical modeling can account for confounding by collinear co-exposures. We use this framework to examine associations between prenatal exposure to OPs and behavior, executive functioning, and IQ assessed at age 6-9 years in a cohort of 404 mother/infant pairs recruited during pregnancy...
July 22, 2017: Environmental Research
https://www.readbyqxmd.com/read/28743036/recist-response-and-variation-of-circulating-tumour-cells-in-phase-1-trials-a-prospective-multicentric-study
#12
Christophe Massard, Isabelle Borget, Françoise Farace, Sandrine Aspeslagh, Marie-Cécile Le Deley, Christophe Le Tourneau, François-Clement Bidard, Jean-Yves Pierga, Veronique Dieras, Paul Hofman, Jean-Philippe Spano, Charles Ferte, Ludovic Lacroix, Jean-Charles Soria
BACKGROUND: Circulating tumour cell (CTC) counting could be a new biomarker for better evaluation of tumour response to molecules tested in phase I trials. PATIENTS AND METHODS: Consenting patients with advanced metastatic cancer referred to various phase I units were enrolled prospectively in this study. CTCs from 7.5 ml of whole blood drawn at baseline and after starting experimental therapy were counted using the CellSearch system, and tumour response was assessed using RECIST 1...
July 22, 2017: European Journal of Cancer
https://www.readbyqxmd.com/read/28742994/unusual-case-of-a-massive-macroglossia-secondary-to-myxedema-a-case-report-and-literature-review
#13
James C Melville, Kelsey D Menegotto, Timothy C Woernley, Blake D Maida, Ibrahim Alava
Macroglossia is classified as true macroglossia, which exhibits abnormal histology with clinical findings, and relative macroglossia, in which normal histology does not correlate with pathologic enlargement. This report describes an atypical case of morbidity with massive macroglossia secondary to myxedema; the macroglossia enlarged over a 3-month period before being presented to the Department of Oral and Maxillofacial Surgery, University of Texas Health Sciences Center at Houston (Houston, TX). Substantial enlargement of the tongue (16 cm long × 10 cm wide) was first attributed to angioedema, which was refractory to the discontinuation of lisinopril and a C1 esterase inhibitor...
June 30, 2017: Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/28742981/increased-precipitation-accelerates-soil-organic-matter-turnover-associated-with-microbial-community-composition-in-topsoil-of-the-alpine-grassland-on-the-eastern-tibetan-plateau
#14
Conghai Han, Zongli Wang, Guicai Si, Tianzhu Lei, Yanli Yuan, Gengxin Zhang
Large quantities of carbon are stored in the alpine grassland of the Tibetan Plateau (TP), where is extremely sensitive to climate change. However, it remains unclear whether soil organic matter (SOM) in different layers responds to climate change analogously, and whether microbial communities play vital roles in SOM turnover of topsoil. In this study we measured and collected SOM turnover by <sup>14</sup>C method in the alpine grassland to test climatic effects on SOM turnover in soil profiles...
July 25, 2017: Canadian Journal of Microbiology
https://www.readbyqxmd.com/read/28742980/disease-relevant-modifications-of-the-methylome-and-transcriptome-by-particulate-matter-pm2-5-from-biomass-combustion
#15
Katharina Heßelbach, Gwang-Jin Kim, Stephan Flemming, Thomas Häupl, Marc Bonin, Regina Dornhof, Stefan Günther, Irmgard Merfort, Matjaz Humar
Exposure to particulate matter (PM) is recognized as a major health hazard, but molecular responses are still insufficiently described. We analyzed the epigenetic impact of ambient PM2.5 from biomass combustion on the methylome of primary human bronchial epithelial BEAS-2B cells using the Illumina HumanMethylation450 BeadChip. The transcriptome was determined by the Affymetrix HG-U133 Plus 2.0 Array. PM2.5 induced genome wide alterations of the DNA methylation pattern, including differentially methylated CpGs in the promoter region associated with CpG islands...
July 25, 2017: Epigenetics: Official Journal of the DNA Methylation Society
https://www.readbyqxmd.com/read/28742975/tumor-imaging-instruction-and-assessment-at-chiropractic-colleges-in-north-america-a-pilot-study-with-implications-for-national-board-of-chiropractic-examiners-content
#16
Kathleen L Linaker, Sarah A Arpin, Charles P Fischer, Michael Sackett, Lesley Georger
OBJECTIVE: This pilot study tested a survey instrument pertaining to the instruction and assessment of tumor imaging in chiropractic training programs. The secondary purpose was to gather data regarding credentials of lead instructors, textbook and resource use, and tumors taught and assessed. METHODS: An electronic survey was distributed to lead tumor imaging instructors at all chiropractic colleges in the United States and Canada. A focus group of tumor imaging instructors was conducted to clarify ambiguous data...
July 25, 2017: Journal of Chiropractic Education
https://www.readbyqxmd.com/read/28742971/evidence-for-quinone-redox-chemistry-mediating-daytime-and-nighttime-no2-to-hono-conversion-on-soil-surfaces
#17
Nicole K Scharko, Erin T Martin, Yaroslav B Losovyj, Dennis G Peters, Jonathan D Raff
Humic acid (HA) is thought to promote NO2 conversion to nitrous acid (HONO) on soil surfaces during the day. However, it has proven difficult to identify the reactive sites in natural HA substrates. The mechanism of NO2 reduction on soil surrogates comprised of HA and clay minerals was studied by use of a coated-wall flow reactor coupled to cavity-enhanced spectroscopy. Conversion of NO2 to HONO in the dark was found to be significant and correlated to the abundance of C‒O moieties in HA determined from X-ray photoelectron spectra of the C1s region...
July 25, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/28742962/characterization-of-intramolecular-interactions-of-cytochrome-c-using-hydrogen-deuterium-exchange-trapped-ion-mobility-spectrometry-mass-spectrometry-and-molecular-dynamics
#18
Juan Camilo Molano-Arevalo, Kevin Jeanne Dit Fouque, Khoa N Pham, Jaroslava Miksovska, Mark E Ridgeway, Melvin A Park, Francisco Fernandez-Lima
Globular proteins, such as cytochrome c (cyt c), display an organized native conformation, maintained by a hydrogen bond interaction network. In the present work, the structural interrogation of kinetically trapped intermediates of cyt c was performed by correlating the ion-neutral collision cross section (CCS) and charge state with the starting solution conditions and time after desolvation using collision induced activation (CIA), time resolved hydrogen/deuterium back exchange (HDX) and trapped ion mobility spectrometry - mass spectrometry (TIMS-MS)...
July 25, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28742884/reduced-expression-of-e-cadherin-and-increased-sialylation-level-in-clear-cell-renal-cell-carcinoma
#19
Małgorzata Borzym-Kluczyk, Iwona Radziejewska, Marzanna Cechowska-Pasko, Barbara Darewicz
Cancer cells are characterized by an aberrant increase in protein N-glycosylation and by disruption of E-cadherin-mediated adherens junctions. However, the relationship between alterations in N-glycosylation process and loss of E-cadherin adhesion in cancer remains unclear. The mechanisms of altered expression of adhesive glycoproteins in cancer cells have not been fully elucidated. Thus, the aim of this study was to examine the expression of E-cadherin and sialyl Lewis(a)/(x), NeuAcα2-3Gal, NeuAcα2-6Gal/GalNAc structures in the normal renal tissue and intermediate and cancerous tissues from patients with clear cell RCC...
July 24, 2017: Acta Biochimica Polonica
https://www.readbyqxmd.com/read/28742874/the-relationship-between-early-and-late-event-related-potentials-and-temperament-in-adolescents-with-and-without-adhd
#20
Brittany R Alperin, Hanna Gustafsson, Christiana Smith, Sarah L Karalunas
Differences in emotional processing are prevalent in adolescents with attention deficit/hyperactivity disorder (ADHD) and are related to clinical impairment, but substantial heterogeneity exists. Within ADHD, some individuals experience difficulty with positive/approach emotions, negative/withdrawal emotions, or both. These problems may reflect differences in emotional reactivity, emotion regulation, or a combination, and the neurophysiological correlates remain unclear. Event-related potentials were collected from 109 adolescents (49 with ADHD) while they completed an emotional go/no-go task with three conditions: happy (positive/approach), fear (negative/withdrawal), and neutral...
2017: PloS One
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