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https://www.readbyqxmd.com/read/28102978/pretreatment-cardiometabolic-status-in-youth-with-early-onset-psychosis-baseline-results-from-the-tea-trial
#1
Karsten G Jensen, Christoph U Correll, Ditte Rudå, Dea G Klauber, Marie Stentebjerg-Olesen, Birgitte Fagerlund, Jens Richardt Møllegaard Jepsen, Anders Fink-Jensen, Anne Katrine Pagsberg
OBJECTIVE: To describe pretreatment cardiometabolic constitution in children and adolescents with first-episode psychosis (FEP). METHODS: Baseline cardiometabolic assessment was performed in youths aged 12-17 years with FEP entering the Tolerability and Efficacy of Antipsychotics (TEA) trial and matched healthy controls. Patients were included between June 10, 2010, and January 29, 2014. ICD-10 was used as the diagnostic classification system. Cardiometabolic risk markers were compared between patients versus controls and antipsychotic-naive versus antipsychotic-exposed patients...
January 17, 2017: Journal of Clinical Psychiatry
https://www.readbyqxmd.com/read/28102972/evaluating-the-clinical-copd-questionnaire-a-systematic-review
#2
REVIEW
Zijing Zhou, Aiyuan Zhou, Yiyang Zhao, Ping Chen
The Clinical COPD Questionnaire (CCQ) is recommended by the Global Initiative for Chronic Obstructive Lung Disease (GOLD) to evaluate health status in patients with COPD. The objective of this work was to systemically assess the reliability, validity, responsiveness and minimum clinically important difference (MCID) of the CCQ. A structured search was conducted in three databases to identify articles that evaluated the psychometric properties of the CCQ in individuals with COPD. Two investigators screened the title, abstract and full text of the articles to determine study eligibility and performed the data extraction...
February 2017: Respirology: Official Journal of the Asian Pacific Society of Respirology
https://www.readbyqxmd.com/read/28102966/histone-deacetylase-2-is-decreased-in-peripheral-blood-pro-inflammatory-cd8-t-and-nkt-like-lymphocytes-following-lung-transplant
#3
Greg Hodge, Sandra Hodge, Chien-Li Holmes-Liew, Paul N Reynolds, Mark Holmes
BACKGROUND AND OBJECTIVE: Immunosuppression therapy following lung transplantation fails to prevent chronic rejection in many patients, which is associated with lack of suppression of cytotoxic mediators and pro-inflammatory cytokines in peripheral blood T and natural killer T (NKT)-like cells. Histone acetyltransferases (HATs) and histone deacetylases (HDACs) upregulate/downregulate pro-inflammatory gene expression, respectively; however, differences in the activity of these enzymes following lung transplant are unknown...
February 2017: Respirology: Official Journal of the Asian Pacific Society of Respirology
https://www.readbyqxmd.com/read/28102961/assessing-the-use-of-4dct-ventilation-in-pre-operative-surgical-lung-cancer-evaluation
#4
Yevgeniy Vinogradskiy, Matthew Jackson, Leah Schubert, Bernard Jones, Richard Castillo, Edward Castillo, Thomas Guerrero, John Mitchell, Chad Rusthoven, Moyed Miften, Brian Kavanagh
PURPOSE: A primary treatment option for lung cancer patients is surgical resection. Patients who have poor lung function prior to surgery are at increased risk of developing serious and life-threatening complications after surgical resection. Surgeons use nuclear medicine ventilation-perfusion (VQ) scans along with pulmonary function test (PFT) information to assess a patient's pre-surgical lung function. The nuclear medicine images and pre-surgery PFTs are used to calculate percent predicted postoperative (%PPO) PFT values by estimating the amount of functioning lung tissue that would be lost with surgical resection...
January 2017: Medical Physics
https://www.readbyqxmd.com/read/28102957/rf-safety-assessment-of-a-bilateral-four-channel-transmit-receive-7-tesla-breast-coil-sar-versus-tissue-temperature-limits
#5
Thomas M Fiedler, Mark E Ladd, Andreas K Bitz
PURPOSE: The purpose of this work was to perform an RF safety evaluation for a bilateral four-channel transmit/receive breast coil and to determine the maximum permissible input power for which RF exposure of the subject stays within recommended limits. The safety evaluation was done based on SAR as well as on temperature simulations. In comparison to SAR, temperature is more directly correlated with tissue damage, which allows a more precise safety assessment. The temperature simulations were performed by applying three different blood perfusion models as well as two different ambient temperatures...
January 2017: Medical Physics
https://www.readbyqxmd.com/read/28102947/a-feasibility-study-of-an-integrated-nir-gamma-visible-imaging-system-for-endoscopic-sentinel-lymph-node-mapping
#6
Han Gyu Kang, Ho-Young Lee, Kyeong Min Kim, Seong-Hyun Song, Gun Chul Hong, Seong Jong Hong
PURPOSE: The aim of this study is to integrate NIR, gamma, and visible imaging tools into a single endoscopic system to overcome the limitation of NIR using gamma imaging and to demonstrate the feasibility of endoscopic NIR/gamma/visible fusion imaging for sentinel lymph node (SLN) mapping with a small animal. METHODS: The endoscopic NIR/gamma/visible imaging system consists of a tungsten pinhole collimator, a plastic focusing lens, a BGO crystal (11 × 11 × 2 mm(3) ), a fiber-optic taper (front = 11 × 11 mm(2) , end = 4 × 4 mm(2) ), a 122-cm long endoscopic fiber bundle, an NIR emission filter, a relay lens, and a CCD camera...
January 2017: Medical Physics
https://www.readbyqxmd.com/read/28102914/nano-koosh-balls-of-mesoporous-mno2-improved-supercapacitor-performance-through-superior-ion-transport
#7
Aasheesh Srivastava, Qysar Maqbool, Chanderpratap Singh, Priyajit Jash, Amit Paul
Manganese dioxide nanomaterials with "Koosh-ball" like morphology (MnO2-KBs) as well as worm-like nanotubes (MnO2-NWs) were obtained by employing Tween 20 as the reducing-cum-structure-directing agent, and KMnO4 as a MnO2 precursor. While the MnO2-KBs were interconnected with each other through tubular extensions, MnO2-NWs were largely disconnected. Both MnO2-KBs and MnO2-NWs had large BET surface areas (>200 m2/g), and were thermally robust upto 300 ⁰C. The electrochemical studies revealed that the highest specific capacitance (Csp) obtained for MnO2-KBs was significantly higher (272 F/g) than that of MnO2-NWs (129 F/g)...
January 19, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28102913/autumn-photosynthetic-decline-and-growth-cessation-in-seedlings-of-white-spruce-are-decoupled-under-warming-and-photoperiod-manipulations
#8
Joseph R Stinziano, Danielle A Way
Climate warming is expected to increase the seasonal duration of photosynthetic carbon fixation and tree growth in high latitude forests. However photoperiod, a crucial cue for seasonality, will remain constant, which may constrain tree responses to warming. We investigated the effects of temperature and photoperiod on weekly changes in photosynthetic capacity, leaf biochemistry and growth in seedlings of a boreal evergreen conifer, white spruce (Picea glauca (Moench) Voss). Warming delayed autumn declines in photosynthetic capacity, extending the period when seedlings had high carbon uptake...
January 19, 2017: Plant, Cell & Environment
https://www.readbyqxmd.com/read/28102877/feasibility-acceptability-and-construct-validity-of-eq-5d-in-systemic-sclerosis
#9
Roberta Gualtierotti, Francesca Ingegnoli, Luciana Scalone, Paolo Cortesi, Eleonora Bruschi, Maria Gerosa, Pier Luigi Meroni
BACKGROUND: Systemic sclerosis is a chronic disabling disease that is often associated with severe physical and psychological impairment. Nonetheless, health-related quality of life (HRQoL) in patients with systemic sclerosis is often left behind in clinical practice and research. One of the reasons for this lack of evaluation is the current use of tools, such as the short form-36 (SF-36) questionnaire, that are complete but complicated to use in everyday routine. Other self-reported outcome measures such as the health assessment questionnaire (HAQ) are simple, but specifically designed for physical disability...
January 19, 2017: Swiss Medical Weekly
https://www.readbyqxmd.com/read/28102862/mutation-spectrum-in-the-abcc6-gene-and-genotype-phenotype-correlations-in-a-french-cohort-with-pseudoxanthoma-elasticum
#10
Anne Legrand, Laurence Cornez, Wafa Samkari, Jean-Michael Mazzella, Annabelle Venisse, Valérie Boccio, Karine Auribault, Boris Keren, Karelle Benistan, Dominique P Germain, Michael Frank, Xavier Jeunemaitre, Juliette Albuisson
PURPOSE: Pseudoxanthoma elasticum (PXE) is an autosomal recessive disorder caused by variants in the ABCC6 gene. Ectopic mineralization of connective tissues leads to skin, eye, and cardiovascular manifestations with considerable phenotypic variability of unknown cause. We aimed to identify genotype-phenotype correlations in PXE. METHODS: A molecular analysis was performed on 458 French PXE probands clinically evaluated using the Phenodex score (PS). Variant topographic analysis and genotype-phenotype correlation analysis were performed according to the number and type of identified variants...
January 19, 2017: Genetics in Medicine: Official Journal of the American College of Medical Genetics
https://www.readbyqxmd.com/read/28102845/h19-let-7-lin28-reciprocal-negative-regulatory-circuit-promotes-breast-cancer-stem-cell-maintenance
#11
Fei Peng, Ting-Ting Li, Kai-Li Wang, Guo-Qing Xiao, Ju-Hong Wang, Hai-Dong Zhao, Zhi-Jie Kang, Wen-Jun Fan, Li-Li Zhu, Mei Li, Bai Cui, Fei-Meng Zheng, Hong-Jiang Wang, Eric W-F Lam, Bo Wang, Jie Xu, Quentin Liu
Long noncoding RNA-H19 (H19), an imprinted oncofetal gene, has a central role in carcinogenesis. Hitherto, the mechanism by which H19 regulates cancer stem cells, remains elusive. Here we show that breast cancer stem cells (BCSCs) express high levels of H19, and ectopic overexpression of H19 significantly promotes breast cancer cell clonogenicity, migration and mammosphere-forming ability. Conversely, silencing of H19 represses these BCSC properties. In concordance, knockdown of H19 markedly inhibits tumor growth and suppresses tumorigenesis in nude mice...
January 19, 2017: Cell Death & Disease
https://www.readbyqxmd.com/read/28102838/autophagy-dysregulation-in-danon-disease
#12
Anna Chiara Nascimbeni, Marina Fanin, Corrado Angelini, Marco Sandri
The autophagy-lysosome system is critical for muscle homeostasis and defects in lysosomal function result in a number of inherited muscle diseases, generally referred to as autophagic vacuolar myopathies (AVMs). Among them, Danon Disease (DD) and glycogen storage disease type II (GSDII) are due to primary lysosomal protein defects. DD is characterized by mutations in the lysosome-associated membrane protein 2 (LAMP2) gene. The DD mouse model suggests that inefficient lysosome biogenesis/maturation and impairment of autophagosome-lysosome fusion contribute to the pathogenesis of muscle wasting...
January 19, 2017: Cell Death & Disease
https://www.readbyqxmd.com/read/28102828/thermodynamic-scaling-of-relaxation-insights-from-anharmonic-elasticity
#13
Sebastiano Bernini, Francesco Puosi, Dino Leporini
We investigate by Molecular Dynamics simulations of a molecular liquid the thermodynamic scaling (TS) of the structural relaxation time $\tau_\alpha$ in terms of the quantity $T\rho^{-\gamma_{ts}}$ where T and rho are the temperature and the density, respectively. The liquid does not exhibit strong virial-energy correlations. We propose how to evaluate both the characteristic exponent $\gamma_{ts}$ and the TS master curve by resorting to experimentally accessible quantities characterising the anharmonic elasticity and no details about the microscopic interactions...
January 19, 2017: Journal of Physics. Condensed Matter: An Institute of Physics Journal
https://www.readbyqxmd.com/read/28102741/tutorial-on-biostatistics-linear-regression-analysis-of-continuous-correlated-eye-data
#14
Gui-Shuang Ying, Maureen G Maguire, Robert Glynn, Bernard Rosner
PURPOSE: To describe and demonstrate appropriate linear regression methods for analyzing correlated continuous eye data. METHODS: We describe several approaches to regression analysis involving both eyes, including mixed effects and marginal models under various covariance structures to account for inter-eye correlation. We demonstrate, with SAS statistical software, applications in a study comparing baseline refractive error between one eye with choroidal neovascularization (CNV) and the unaffected fellow eye, and in a study determining factors associated with visual field in the elderly...
January 19, 2017: Ophthalmic Epidemiology
https://www.readbyqxmd.com/read/28102738/optimization-and-partial-characterization-of-intracellular-anticandidal-protein-from-aspergillus-giganteus-mtcc-8408-using-taguchi-doe
#15
Debashis Dutta, Mira Debnath Das
A new intracellular antifungal protein (afp) production with average molecular weight 24.3 kDa and yield of 0.65 ± 0.1 mg/gram dry cell weight (gdcw) of mycelia in submerged fermentation of Aspergillus giganteus MTCC 8408 was optimized. Taguchi's DOE (design of experiment) L27 orthogonal array (OA) was constructed using Qualitek-4 software with 8 most influensive factors namely, culture pH, temperature, slant age, inoculum volume, agitation and KH2PO4. Scanning electron microscopy (SEM) was used to correlate the effect of selected factors on fungal cell morphology and afp production...
January 19, 2017: Bioengineered
https://www.readbyqxmd.com/read/28102714/validity-and-reliability-of-a-questionnaire-to-assess-social-skills-in-traumatic-brain-injury-a-preliminary-study
#16
Heather M Francis, Katherine Osborne-Crowley, Skye McDonald
OBJECTIVE: To describe the reliability and validity of a new measure, the Social Skills Questionnaire for Traumatic Brain Injury (SSQ-TBI). METHODS: Fifty-one adults with severe TBI completed the SSQ-TBI questionnaire. Scores were compared to informant- and self-report on questionnaires addressing frontal lobe mediated behaviour, as well as performance on an objective measure of social cognition and neuropsychological tasks, in order to provide evidence of concurrent, divergent and predictive validity...
January 19, 2017: Brain Injury: [BI]
https://www.readbyqxmd.com/read/28102709/weight-loss-during-initial-chemotherapy-predicts-survival-in-patients-with-advanced-gastric-cancer
#17
Kotoe Takayoshi, Keita Uchino, Masahiro Nakano, Koji Ikejiri, Eishi Baba
BACKGROUND: Patients with advanced gastric cancer (AGC) often suffer weight loss, which can be used to predict prognosis. Few reports have assessed the correlation between weight loss during chemotherapy and survival in patients with AGC. METHODS: Fifty-three patients with histologically proven AGC, who started systemic chemotherapy from September 2010 to March 2014, were retrospectively examined for body weight, inflammatory status, and survival. Correlation analyses were performed between weight change and survival...
January 19, 2017: Nutrition and Cancer
https://www.readbyqxmd.com/read/28102706/co-effect-of-phosphorus-and-cadmium-interaction-on-fraction-distribution-and-accumulation-of-phosphorus-in-mangrove-sediment-system
#18
Jingna Du, Junyi Yu
Mangrove (Kandelia obovata (S. L.)) seedlings were cultivated in rhizoboxes under different rates of phosphorus (P) and cadmium (Cd) level. The speciation distributions of P both in the rhizosphere and non-rhizosphere sediments were examined using sequential extraction procedures. P contents in different Kandelia obovata (S.L.) tissues were also determined. Results showed that considerable differences existed in P speciation distribution between rhizosphere and bulk sediments. A higher proportion of iron-bound phosphate (Fe-P) was found in the rhizosphere sediments, while a relatively higher concentration of exchangeable phosphate (Ex-P) and Al-bound phosphate (Al-P) was found in the bulk sediments...
January 19, 2017: International Journal of Phytoremediation
https://www.readbyqxmd.com/read/28102676/novel-antitumor-platinum-ii-conjugates-containing-the-nonsteroidal-anti-inflammatory-agent-diclofenac-synthesis-and-dual-mechanisms-of-antiproliferative-effects
#19
Francesco Paolo Intini, Juraj Zajac, Vojtech Novohradsky, Teresa Saltarella, Concetta Pacifico, Viktor Brabec, Giovanni Natile, Jana Kasparkova
One concept how to improve anticancer effects of conventional metallodrugs consists in conjugation of these compounds with other biologically (antitumor) active agents, acting by a different mechanism. Here, we present synthesis, biological effects, and mechanisms of action of new Pt(II) derivatives containing one or two nonsteroidal anti-inflammatory diclofenac (DCF) ligands also known for their antitumor effects. The antiproliferative properties of these metallic conjugates show that these compounds are potent and cancer cell selective cytotoxic agents exhibiting activity in cisplatin resistant and the COX-2 positive tumor cell lines...
January 19, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/28102672/coupled-cluster-studies-of-ionization-potentials-and-electron-affinities-of-single-walled-carbon-nanotubes
#20
Bo Peng, Niranjan Govind, Edoardo Aprà, Michael Klemm, Jeff R Hammond, Karol Kowalski
In this paper we apply the equation-of-motion coupled cluster (EOM-CC) methods in the studies of the vertical ionization potentials (IPs) and electron affinities (EAs) for a series of single walled carbon nanotubes (SWCNT). The EOM-CC formulations for IPs and EAs employing excitation manifolds spanned by single and double excitations (IP/EA-EOM-CCSD) are used to study the IPs and EAs of the SWCNTs as a func- tion of the nanotube length. Several armchair nanotubes corresponding to C20nH20 models with n = 2 - 6 have been used in benchmark calculations...
January 19, 2017: Journal of Physical Chemistry. A
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