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https://www.readbyqxmd.com/read/29779274/-outcome-and-influential-factors-of-speech-therapy-delivered-to-cleft-patients-with-post-operative-velopharyngeal-competence
#1
Chun-Li Guo, Heng Yin, Jing-Tao Li, Cheng-Hao Li, Yang Li, Bing Shi, Qian Zheng
OBJECTIVE: To analyze the training technique, intervention timing, and other related factors involved in the speech therapy delivered to cleft patients with velopharyngeal competence after surgery. METHODS: A retrospective study was conducted on 32 patients who received phonology-articulation speech therapies during 2012 to 2013 in Dept. of Cleft Lip and Palate, West China Hospital of Stomatology, Sichuan University. All patients achieved normal speech one year after therapy...
April 1, 2018: Hua Xi Kou Qiang Yi Xue za Zhi, Huaxi Kouqiang Yixue Zazhi, West China Journal of Stomatology
https://www.readbyqxmd.com/read/29779267/%C3%AE-synuclein-activates-innate-immunity-but-suppresses-interferon-%C3%AE-expression-in-murine-astrocytes
#2
Jintang Wang, Zheng Chen, Jeremy Walston, Peisong Gao, Maolong Gao, Sean X Leng
Glial activation and neuroinflammation contribute to pathogenesis of neurodegenerative diseases, linked to neuron loss and dysfunction. α-Synuclein (α-syn), as a metabolite of neuron, can induce microglia activation to trigger innate immune response. However, whether α-syn, as well as its mutants (A53T, A30P and E46K), induces astrocyte activation and inflammatory response is not fully elucidated. In this study, we used A53T mutant and wildtype α-syns to stimulate primary astrocytes in dose- and time-dependent manners (0...
May 19, 2018: European Journal of Neuroscience
https://www.readbyqxmd.com/read/29779257/linking-seed-germination-and-plant-height-a-case-study-of-a-wetland-community-on-the-eastern-tibet-plateau
#3
Kun Liu, Suzhen Cao, Guozhen Du, Jerry M Baskin, Carol C Baskin, Haiyan Bu, Wei Qi, Ting Liang
Seed germination is the earliest trait expressed in a plant's life history, and it can directly affect the expression of post germination traits. Plant height is central to plant ecological strategies, because it is a major determinant of the ability of a species to compete for light. Thus, linking seed germination and plant height at the community level is very important to understanding plant fitness and community structure. Here, we tested storage condition and temperature requirements for germination of 31 species from a wetland plant community on the eastern Tibet Plateau, and analyzed correlation of germination traits with plant height in relation to storage condition...
May 20, 2018: Plant Biology
https://www.readbyqxmd.com/read/29779248/analysis-of-intraspecific-seeds-diversity-in-astragalus-aquilanus-fabaceae-endemic-species-of-central-apennine
#4
V Di Cecco, M Di Musciano, A A D'Archivio, A R Frattaroli, L Di Martino
This work aims to study the seeds of the endemic species Astragalus aquilanus from four different populations of Central Italy. We investigated the seed morpho-colorimetric features (shape and size) and chemical differences (through infrared spectroscopy) among populations and between dark and light seeds. Seed morpho-colorimetric quantitative variables, describing shape, size and colour seed traits, were measured using image analysis techniques. Fourier transform infrared (FT-IR) spectroscopy was used to attempt seed chemical characterization...
May 20, 2018: Plant Biology
https://www.readbyqxmd.com/read/29779236/arabidopsis-inositol-phosphate-kinases-ipk1-and-itpk1-constitute-a-metabolic-pathway-in-maintaining-phosphate-homeostasis
#5
Hui-Fen Kuo, Yu-Ying Hsu, Wei-Chi Lin, Kai-Yu Chen, Teun Munnik, Charles A Brearley, Tzyy-Jen Chiou
Emerging studies have implicated a close link between inositol phosphate (InsP) metabolism and cellular phosphate (Pi ) homeostasis in eukaryotes; however, whether a common InsP species is deployed as an evolutionarily conserved metabolic messenger to mediate Pi signaling remains unknown. Here, using genetics and InsP profiling combined with Pi starvation response (PSR) analysis in Arabidopsis thaliana, we showed that the kinase activity of inositol pentakisphosphate 2-kinase (IPK1), an enzyme required for phytate (inositol hexakisphosphates; InsP6 ) synthesis, is indispensable for maintaining Pi homeostasis under Pi -replete conditions, and inositol 1,3,4-trisphosphate 5/6-kinase 1 (ITPK1) plays an equivalent role...
May 19, 2018: Plant Journal: for Cell and Molecular Biology
https://www.readbyqxmd.com/read/29779226/phenotypic-characterization-of-enzymatic-activity-of-clinical-dermatophyte-isolates-from-animals-with-and-without-skin-lesions-and-humans
#6
Sebastian Gnat, Dominik Łagowski, Aneta Nowakiewicz, Przemysław Zięba
AIMS: The pathogenesis of dermatophytoses is associated with the secretion of enzymes degrading the infected tissue components. Although many studies on enzymatic activity of dermatophytes have been conducted over the years, there have been no concrete proposals on construction of the profile of enzymes characteristic of individual species, genus, or ecological types of dermatophytes. The aim of this study was to assess the capability of clinical dermatophyte isolates from both symptomatic and asymptomatic animals and humans to produce different enzymes...
May 20, 2018: Journal of Applied Microbiology
https://www.readbyqxmd.com/read/29779218/an-analysis-of-the-timing-and-materials-associated-with-pulp-disease-following-restorative-dental-treatment
#7
J B Yong, S Sivarajan, P V Abbott
AIM: To assess whether the timing of pulp disease after tooth restoration was associated with type of restorative dental material used, extent of the restoration, or tooth type. METHODOLOGY: A comprehensive search and analysis of data using the Titanium Oral Health Management software program at The Oral Health Centre of Western Australia was performed to correlate procedural codes for teeth that had restorations placed and subsequently developed pulp disease requiring endodontic treatment or extraction from 1st January 2009 to 31st December 2013...
May 19, 2018: International Endodontic Journal
https://www.readbyqxmd.com/read/29779211/cutaneous-sarcoidosis-a-new-subset-in-the-spectrum-of-paraneoplastic-dermatoses
#8
M El-Khalawany, A Mosbeh, S Aboeldahab, S Ali
BACKGROUND: Sarcoidosis is a well-described disease that can be associated with various malignancies; however, this correlation is still not fully clarified. AIM: To determine the clinical and histological features, demographic characteristics, and prognosis of patients diagnosed with paraneoplastic sarcoidosis (PS). METHODS: This observational cohort prospective study included all patients diagnosed as cutaneous sarcoidosis. All patients were monitored for therapeutic response, prognosis, and any associated diseases or malignancies...
May 20, 2018: Clinical and Experimental Dermatology
https://www.readbyqxmd.com/read/29779191/consequences-of-structural-modifications-in-cytochrome-b-559-on-the-electron-acceptor-side-of-photosystem-ii
#9
Makoto Nakamura, Alain Boussac, Miwa Sugiura
Cytb559 in Photosystem II is a heterodimeric b-type cytochrome. The subunits, PsbE and PsbF, consist each in a membrane α-helix. Mutants were previously designed and studied in Thermosynechococcus elongatus (Sugiura et al., Biochim Biophys Acta 1847:276-285, 2015) either in which an axial histidine ligand of the haem-iron was substituted for a methionine, the PsbE/H23M mutant in which the haem was lacking, or in which the haem environment was modified, the PsbE/Y19F and PsbE/T26P mutants. All these mutants remained active showing that the haem has no structural role provided that PsbE and PsbF subunits are present...
May 19, 2018: Photosynthesis Research
https://www.readbyqxmd.com/read/29779167/mir-199b-5p-regulates-immune-mediated-allograft-rejection-after-lung-transplantation-through-the-gsk3%C3%AE-and-nf-%C3%AE%C2%BAb-pathways
#10
Linhai Zhu, Haichao Xu, Wang Lv, Zhehao He, Peng Ye, Yiqing Wang, Jian Hu
Emerging evidence indicates that acute rejection mainly associated with the inflammatory response is an independent risk factor for chronic rejection after lung transplantation. Monocytes are the main pro-inflammatory leukocytes infiltrating around the lesions and play vital roles in triggering the acute rejection. In the rat lung transplantation model, lipopolysaccharide (LPS)-induced severe acute rejection was strongly associated with advanced chronic rejection. The exact regulatory mechanism of pro-inflammation in monocytes is not yet clear...
May 19, 2018: Inflammation
https://www.readbyqxmd.com/read/29779156/adolescent-isolation-rearing-produces-a-prepulse-inhibition-deficit-correlated-with-expression-of-the-nmda-glun1-subunit-in-the-nucleus-accumbens
#11
Megan L Fitzgerald, Virginia M Pickel
Adolescence is a transition period during which social interaction is necessary for normal brain and behavior development. Severely abnormal social interactions during adolescence can increase the incidence of lifelong psychiatric disease. Decreased prepulse inhibition (PPI) is a quantifiable hallmark of some psychiatric illnesses in humans and can be elicited in rodents by isolation rearing throughout the adolescent transition period. PPI is a measure of sensorimotor gating in which the nucleus accumbens (Acb) is crucially involved...
May 19, 2018: Brain Structure & Function
https://www.readbyqxmd.com/read/29779154/the-effect-of-meteorological-conditions-and-air-pollution-on-the-occurrence-of-type-a-and-b-acute-aortic-dissections
#12
Nan Xie, Liqun Zou, Lei Ye
To explore the association of weather conditions and air pollutants with incidence risk of acute aortic dissection (AAD), we included patients who consecutively admitted to the emergency units of our hospital for AAD between Dec. 1, 2013, and Apr. 30, 2017. Their medical records were reviewed. The meteorological data (daily precipitation, minimal and maximal temperatures, mean atmospheric pressure, relative humidity) and air pollutants values [air daily index (AQI), aerodynamic diameter of 2.5 mm or less (PM2...
May 19, 2018: International Journal of Biometeorology
https://www.readbyqxmd.com/read/29779146/food-addiction-orthorexia-and-food-related-stress-among-dietetics-students
#13
Maria G Grammatikopoulou, Konstantinos Gkiouras, Anastasia Markaki, Xenophon Theodoridis, Vasiliki Tsakiri, Pantelis Mavridis, Theodore Dardavessis, Michael Chourdakis
PURPOSE: Health sciences, and in particular Nutrition and Dietetics students, have been shown to exhibit an increased prevalence of disordered eating. The aim of the present cross-sectional study was to evaluate other specified feeding and eating disorders (OSFEDs), including stress-related eating, food addiction, and orthorexia, in relation to the dietary intake, among nutrition/dietetics students. METHODS: A total of 176 undergraduate students from a Department of Nutrition and Dietetics, in Greece, participated in the study...
May 19, 2018: Eating and Weight Disorders: EWD
https://www.readbyqxmd.com/read/29779142/arousal-index-as-a-marker-of-carotid-artery-atherosclerosis-in-patients-with-obstructive-sleep-apnea-syndrome
#14
Mayumi Suzuki, Ken Shimamoto, Haruki Sekiguchi, Takamitsu Harada, Natsumi Satoya, Yuji Inoue, Kazuhiro Yamaguchi, Masatoshi Kawana
PURPOSE: It was shown in a previous cohort study that men with internal carotid artery (ICA) plaque, defined as focal wall thickness of ≥ 1.5 mm, had a threefold higher risk of stroke than those without plaque. We examined the relationship between arousal indices and sleep stages in patients with obstructive sleep apnea syndrome (OSAS) and carotid atherosclerosis. METHODS: Carotid atherosclerosis severity was evaluated using the maximal carotid wall intima-media thickness of the ICA (ICA-maxIMT) and plaque in 83 patients with OSAS...
May 19, 2018: Sleep & Breathing, Schlaf & Atmung
https://www.readbyqxmd.com/read/29779125/genetic-diversity-and-structure-of-a-rare-endemic-cactus-and-an-assessment-of-its-genetic-relationship-with-a-more-common-congener
#15
Niraj Rayamajhi, Jyotsna Sharma
Endemic, obligate outcrossing plant species with narrow geographic distributions and disjunct populations are prone to loss of genetic diversity. Simultaneously, delineating clear species boundaries is important for targeted conservation efforts. The rare and endemic cactus, Sclerocactus brevihamatus subsp. tobuschii (SBT), has a parapatric relationship with Sclerocactus brevihamatus subsp. brevihamatus (SBB) but genetic distance between the two taxa is unknown. We: (1) developed taxon-specific polymorphic microsatellites, (2) assessed genetic diversity within and among nine populations of SBT, and within one population of SBB, and (3) estimated the genetic relationship between the two subspecies...
May 19, 2018: Genetica
https://www.readbyqxmd.com/read/29779103/dopamine-synthesis-as-a-mechanism-of-brain-plasticity-in-nigrostriatal-system-pathology
#16
A A Kolacheva, M V Ugrumov
Using an experimental Parkinson's disease model (symptoms develop in mice after the injection of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine), we studied the characteristics of the synthesis of dopamine as a possible compensatory mechanism aimed at maintaining the dopamine level in the dopaminergic neurons that survived in this pathology. We found no correlation between the content and activity of tyrosine hydroxylase in the nigrostriatal system. The enzyme activity and the dopamine content showed unidirectional changes in the substantia nigra, but not in the striatum, which is apparently due to triggering other compensatory mechanisms...
March 2018: Doklady. Biochemistry and Biophysics
https://www.readbyqxmd.com/read/29779088/proteomic-analysis-dissects-the-impact-of-nodulation-and-biological-nitrogen-fixation-on-vicia-faba-root-nodule-physiology
#17
Beate Thal, Hans-Peter Braun, Holger Eubel
Symbiotic nitrogen fixation in root nodules of legumes is a highly important biological process which is only poorly understood. Root nodule metabolism differs from that of roots. Differences in root and nodule metabolism are expressed by altered protein abundances and amenable to quantitative proteome analyses. Differences in the proteomes may either be tissue specific and related to the presence of temporary endosymbionts (the bacteroids) or related to nitrogen fixation activity. An experimental setup including WT bacterial strains and strains not able to conduct symbiotic nitrogen fixation as well as root controls enables identification of tissue and nitrogen fixation specific proteins...
May 19, 2018: Plant Molecular Biology
https://www.readbyqxmd.com/read/29779085/progressive-grey-matter-volume-changes-in-patients-with-schizophrenia-over-6-weeks-of-antipsychotic-treatment-and-their-relationship-to-clinical-improvement
#18
Xiao Zhang, Yuyanan Zhang, Jinmin Liao, Sisi Jiang, Jun Yan, Weihua Yue, Dai Zhang, Hao Yan
Cross-sectional and longitudinal studies have identified widespread and progressive grey matter volume (GMV) reductions in schizophrenia, especially in the frontal lobe. In this study, we found a progressive GMV decrease in the rostral medial frontal cortex (rMFC, including the anterior cingulate cortex) in the patient group during a 6-week follow-up of 40 patients with schizophrenia and 31 healthy controls well-matched for age, gender, and education. The higher baseline GMV in the rMFC predicted better improvement in the positive score on the Positive and Negative Syndrome Scale (PANSS), and this might be related to the improved reality-monitoring...
May 19, 2018: Neuroscience Bulletin
https://www.readbyqxmd.com/read/29779072/intratumoral-heterogeneity-on-dedicated-breast-positron-emission-tomography-predicts-malignancy-grade-of-breast-cancer
#19
Norio Masumoto, Takayuki Kadoya, Shinsuke Sasada, Akiko Emi, Koji Arihiro, Morihito Okada
PURPOSE: Dedicated breast positron emission tomography (DbPET) provides detailed high-resolution images and can detect intratumoral heterogeneity using 18 F-fluorodeoxyglucose (FDG). We aimed to evaluate the correlation between FDG uptake on DbPET and the clinicopathological features of breast cancer, particularly those with an intratumoral heterogeneous distribution of FDG on DbPET. METHODS: We evaluated 195 consecutive patients with invasive breast cancer who underwent preoperative whole-body PET (WBPET) and DbPET concurrently between January 2016 and March 2017...
May 19, 2018: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/29779071/steady-state-perg-adaptation-a-conspicuous-component-of-response-variability-with-clinical-significance
#20
P Monsalve, S Ren, G Triolo, L Vazquez, A D Henderson, M Kostic, P Gordon, W J Feuer, V Porciatti
PURPOSE: To investigate within-test variability of the steady-state PERG (SS-PERG). METHODS: SS-PERGs were recorded in response to black-white horizontal gratings (1.6 cycles/deg, 98% contrast, 15.63 reversals/s, LED display, 25 deg square field, 800 cd/sqm mean luminance) using skin electrodes. PERG and noise (± reference) signals were averaged over 1024 epochs (~ 2.2 min) and Fourier analyzed to retrieve SS-PERG amplitude and phase. SS-PERGs were split into 16 partial averages (samples) of 64 epochs each, and corresponding amplitudes and phases combined in polar coordinates to assess their dispersion (within-test variability)...
May 19, 2018: Documenta Ophthalmologica. Advances in Ophthalmology
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