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https://www.readbyqxmd.com/read/27913413/new-arsenate-reductase-gene-arra-pcr-primers-for-diversity-assessment-and-quantification-in-environmental-samples
#1
Babur S Mirza, Darwin L Sorensen, R Ryan Dupont, Joan E McLean
: The extent of arsenic contamination in drinking water and its potential threat to human health have resulted in considerable research interest in the microbial species responsible for arsenic reduction. The arsenate reductase gene (arrA), an important component of the microbial arsenate reduction system, has been widely used as a biomarker to study arsenate reducing microorganisms. A new primer pair was designed and evaluated for qPCR and high-throughput sequencing of the arrA gene, because currently available PCR primers are not suitable for these applications...
December 2, 2016: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/27912137/a-novel-continuous-two-phase-partitioning-bioreactor-operated-with-polymeric-tubing-performance-validation-for-enhanced-biological-removal-of-toxic-substrates
#2
M Concetta Tomei, Domenica Mosca Angelucci, Andrew J Daugulis
A continuous two-phase partitioning bioreactor (C-TPPB), operated with coiled tubing made of the DuPont polymer Hytrel 8206, was tested for the bioremediation of 4-chlorophenol, as a model toxic compound. The tubing was immersed in the aqueous phase, with the contaminated water flowing tube-side, and an adapted microbial culture suspended in the bioreactor itself, with the metabolic demand of the cells creating a concentration gradient to cause the substrate to diffuse into the bioreactor for biodegradation...
November 29, 2016: Journal of Environmental Management
https://www.readbyqxmd.com/read/27896932/mesoionic-insecticides-a-novel-class-of-insecticides-that-modulate-nicotinic-acetylcholine-receptors
#3
Caleb W Holyoke, Daniel Cordova, Wenming Zhang, James D Barry, Robert M Leighty, Robert F Dietrich, James J Rauh, Thomas F Pahutski, George P Lahm, My-Hanh Thi Tong, Eric A Benner, John L Andreassi, Rejane M Smith, Daniel R Vincent, Laurie A Christianson, Luis A Teixeira, Vineet Singh, Kenneth A Hughes
BACKGROUND: As the world population grows toward 9 billion by 2050 it is projected that food production will need to increase by 60%. A critical part of this growth includes the safe and effective use of insecticides to reduce the estimated 20-49% loss of global crop yields due to pests. Development of new insecticides will help sustain this protection and overcome insecticide resistance. RESULTS: A novel class of mesoionic compounds has been discovered with exceptional insecticidal activity on a range of Hemiptera and Lepidoptera...
November 29, 2016: Pest Management Science
https://www.readbyqxmd.com/read/27895813/cow-s-milk-allergy-towards-an-update-of-dracma-guidelines
#4
REVIEW
Alessandro Fiocchi, Lamia Dahda, Christophe Dupont, Cristina Campoy, Vincenzo Fierro, Antonio Nieto
BACKGROUND: In 2010, the diagnosis and treatment of IgE-mediated CMA were systematized in a GRADE guideline. OBJECTIVES & METHODS: After 6 years, the state of the knowledge in diagnosis and treatment of CMA has largely evolved. We summarize here the main advances, and exemplify indicating some specific points: studies aimed at better knowledge of the effects of breastfeeding and the production of new special formulae intended for the treatment of CMA. The literature (PubMed/MEDLINE) was searched using the following algorithms: (1) [milk allergy] AND diagnosis; (2) [milk allergy] AND [formul*] OR [breast*], setting the search engine [6-years] time and [human] limits...
2016: World Allergy Organization Journal
https://www.readbyqxmd.com/read/27894472/-long-term-intravenous-devices-continuity-of-care-from-the-specialist-doctor-to-the-nurse
#5
REVIEW
Irène Kriegel, Lydie Wintz, Christian Dupont, Marguerite Nicodème, Isabelle Fromantin
Long-term intravenous devices have become an essential tool in the treatment of patients requiring the administration of medication over more than one month. The choice of device must be established through consultation between the nursing team and the patient. Several types of complications can be observed immediately after the insertion of the device and during treatment. Protocols in the community and at hospital are therefore necessary in order that doctors, nurses, specialists and experts work together...
November 2016: Soins; la Revue de Référence Infirmière
https://www.readbyqxmd.com/read/27887809/an-estimation-of-burden-of-serious-fungal-infections-in-france
#6
J-P Gangneux, M-E Bougnoux, C Hennequin, C Godet, J Chandenier, D W Denning, B Dupont
OBJECTIVE OF THE STUDY: An estimation of burden of serious fungal diseases in France is essential data to inform public health priorities on the importance of resources and research needed on these infections. In France, precise data are available for invasive fungal diseases but estimates for several other diseases such as chronic and immunoallergic diseases are by contrast less known. MATERIALS AND METHODS: A systematic literature search was conducted using the Web of Science Platform...
November 22, 2016: Journal de Mycologie Médicale
https://www.readbyqxmd.com/read/27886660/evaluation-of-the-safety-and-adjuvant-effect-of-a-detoxified-listeriolysin-o-mutant-on-the-humoral-response-to-dengue-virus-antigens
#7
K G Hernández-Flores, A L Calderón-Garcidueñas, G Mellado-Sánchez, R Ruiz-Ramos, L A Sánchez-Vargas, P Thomas-Dupont, I Y Izaguirre-Hernández, J Téllez-Sosa, J Martínez-Barnetche, L Wood, Y Paterson, L Cedillo-Barrón, O López-Franco, H Vivanco-Cid
Listeriolysin O (LLO) has been proposed as a potential carrier or adjuvant molecule in the vaccination field. However, the cytotoxic and pro-apoptotic effects of LLO are the major limitations for this purpose. Here, we have performed a preclinical safety evaluation and characterized a new potential adjuvant application for a non-cytolytic LLO mutant (dtLLO) to enhance and modulate the immune response against the envelope (E) protein from Dengue virus. In addition, we have studied the adjuvant effects of dtLLO on human immune cells and the role of membrane cholesterol for the binding and the pro-inflammatory property of the toxoid...
November 25, 2016: Clinical and Experimental Immunology
https://www.readbyqxmd.com/read/27873161/fgf-treatment-of-host-embryos-injected-with-es-cells-increases-rates-of-chimaerism
#8
Cathérine Dupont, Friedemann Loos, John Kong-A-San, Joost Gribnau
In spite of the emergence of genome editing tools, ES cell mediated transgenesis remains the most controllable way of creating genetically modified animals. Although tetraploid (4N) complementation of 4N host embryos and ES cells, is the only method guaranteeing that offspring are entirely ES cell derived, this technique is challenging, not always successful and difficult to implement in some laboratory settings. The current study shows that pretreatment of host blastocysts with FGF4 prior to ES cell injection can provide an alternative method for the generation of animals displaying high rates of chimaerism...
November 21, 2016: Transgenic Research
https://www.readbyqxmd.com/read/27872017/secondarily-documented-invasive-candidiasis-is-unpredictable-using-traditional-risk-factors-in-non-transplant-non-neutropenic-adult-icu-patients
#9
Sébastien Bailly, Olivier Leroy, Hervé Dupont, Jean-François Timsit
No abstract text is available yet for this article.
November 18, 2016: International Journal of Infectious Diseases: IJID
https://www.readbyqxmd.com/read/27871145/meta-omic-analyses-of-baltic-sea-cyanobacteria-diversity-community-structure-and-salt-acclimation
#10
Narin Celepli, John Sundh, Martin Ekman, Chris L Dupont, Shibu Yooseph, Birgitta Bergman, Karolina Ininbergs
Cyanobacteria are important phytoplankton in the Baltic Sea, an estuarine-like environment with pronounced north to south gradient in salinity and nutrient concentrations. Here we present a metagenomic and -transcriptomic survey, with subsequent analyses targeting the genetic identity, phylogenetic diversity, and spatial distribution of Baltic Sea cyanobacteria. The cyanobacterial community constituted close to 12% of the microbial population sampled during a pre-bloom period (June-July 2009). The community was dominated by unicellular picocyanobacteria, specifically a few highly abundant taxa (Synechococcus and Cyanobium) with a long tail of low abundance representatives, and local peaks of bloom-forming heterocystous taxa...
November 21, 2016: Environmental Microbiology
https://www.readbyqxmd.com/read/27870616/comparison-of-different-generalizations-of-clustering-coefficient-and-local-efficiency-for-weighted-undirected-graphs
#11
Yu Wang, Eshwar Ghumare, Rik Vandenberghe, Patrick Dupont
Binary undirected graphs are well established, but when these graphs are constructed, often a threshold is applied to a parameter describing the connection between two nodes. Therefore, the use of weighted graphs is more appropriate. In this work, we focus on weighted undirected graphs. This implies that we have to incorporate edge weights in the graph measures, which require generalizations of common graph metrics. After reviewing existing generalizations of the clustering coefficient and the local efficiency, we proposed new generalizations for these graph measures...
November 21, 2016: Neural Computation
https://www.readbyqxmd.com/read/27870570/activating-notch1-mutations-define-a-distinct-subgroup-of-patients-with-adenoid-cystic-carcinoma-who-have-poor-prognosis-propensity-to-bone-and-liver-metastasis-and-potential-responsiveness-to-notch1-inhibitors
#12
Renata Ferrarotto, Yoshitsugu Mitani, Lixia Diao, Irene Guijarro, Jing Wang, Patrick Zweidler-McKay, Diana Bell, William N William, Bonnie S Glisson, Michael J Wick, Ann M Kapoun, Amita Patnaik, Gail Eckhardt, Pamela Munster, Leonardo Faoro, Jakob Dupont, J Jack Lee, Andrew Futreal, Adel K El-Naggar, John V Heymach
Purpose Adenoid cystic carcinomas (ACCs) represent a heterogeneous group of chemotherapy refractory tumors, with a subset demonstrating an aggressive phenotype. We investigated the molecular underpinnings of this phenotype and assessed the Notch1 pathway as a potential therapeutic target. Methods We genotyped 102 ACCs that had available pathologic and clinical data. Notch1 activation was assessed by immunohistochemistry for Notch1 intracellular domain. Luciferase reporter assays were used to confirm Notch1 target gene expression in vitro...
November 21, 2016: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/27867132/learning-curve-for-real-time-ultrasound-guided-percutaneous-tracheostomy
#13
Sandra Petiot, Pierre-Grégoire Guinot, Momar Diouf, Elie Zogheib, Hervé Dupont
OBJECTIVES: The objective of this study was to demonstrate and quantify the ultrasound-guided percutaneous tracheostomy (UPDT) learning curve in a single team since the first UPDT. STUDY DESIGN AND PATIENTS: This was a cohort of all consecutive patients undergoing UPDT in the Amiens teaching hospital surgical intensive care unit between 2010 and 2014. METHODS: The learning process was evaluated according to three aspects: duration of the various steps involved in UPDT, incidence of consecutive complications, and procedure difficulty...
November 17, 2016: Anaesthesia, Critical Care & Pain Medicine
https://www.readbyqxmd.com/read/27866928/improved-waitlist-and-transplant-outcomes-for-pediatric-lung-transplantation-after-implementation-of-the-lung-allocation-score
#14
Timothy S Lancaster, Jacob R Miller, Deirdre J Epstein, Nicholas C DuPont, Stuart C Sweet, Pirooz Eghtesady
BACKGROUND: Although the lung allocation score (LAS) has not been considered valid for lung allocation to children, several additional policy changes for pediatric lung allocation have been adopted since its implementation. We compared changes in waitlist and transplant outcomes for pediatric and adult lung transplant candidates since LAS implementation. METHODS: The United Network for Organ Sharing database was reviewed for all lung transplant listings during the period 1995 to June 2014...
October 17, 2016: Journal of Heart and Lung Transplantation
https://www.readbyqxmd.com/read/27864036/comorbidities-and-the-risk-of-mortality-in-patients-with-bronchiectasis-an-international-multicentre-cohort-study
#15
Melissa J McDonnell, Stefano Aliberti, Pieter C Goeminne, Marcos I Restrepo, Simon Finch, Alberto Pesci, Lieven J Dupont, Thomas C Fardon, Robert Wilson, Michael R Loebinger, Dusan Skrbic, Dusanka Obradovic, Anthony De Soyza, Chris Ward, John G Laffey, Robert M Rutherford, James D Chalmers
BACKGROUND: Patients with bronchiectasis often have concurrent comorbidities, but the nature, prevalence, and impact of these comorbidities on disease severity and outcome are poorly understood. We aimed to investigate comorbidities in patients with bronchiectasis and establish their prognostic value on disease severity and mortality rate. METHODS: An international multicentre cohort analysis of outpatients with bronchiectasis from four European centres followed up for 5 years was done for score derivation...
November 15, 2016: Lancet Respiratory Medicine
https://www.readbyqxmd.com/read/27862404/pristine-ta3-n5-nanotubes-trap-driven-high-external-biasing-perspective-in-semiconductor-electrolyte-interfaces
#16
Sherdil Khan, Marcos J L Santos, Célia F Malfatti, Jairton Dupont, Sérgio R Teixeira
Ta3 N5 is a promising photoelectrode for solar hydrogen production; however, to date pristine Ta3 N5 electrodes without loading co-catalysts have presented limited photoelectrochemical (PEC) performance. In particular, large external biasing has been required to run water oxidation, the origin of which is investigated herein. Ta3 N5 nanotubes (NTs) prepared by nitridation were characterized by a wide range of techniques. The bandgap was confirmed by a novel PEC technique. Nondestructive synchrotron-excited XPS has shown the presence of reduced Ta species deeper in the Ta3 N5 surface...
November 10, 2016: Chemistry: a European Journal
https://www.readbyqxmd.com/read/27860285/1h-1-2-3-triazole-tethered-uracil-ferrocene-and-uracil-ferrocenylchalcone-conjugates-synthesis-and-antitubercular-evaluation
#17
Amandeep Singh, Christophe Biot, Albertus Viljoen, Christian Dupont, Laurent Kremer, Kewal Kumar, Vipan Kumar
Copper-catalyzed azide-alkyne [3 + 2] cycloaddition has been utilized for preparing a series of 1H-1,2,3-triazoles with the purpose of probing structure-activity relationships among a uracil-ferrocene-triazole conjugate family. The antitubercular evaluation studies revealed an improvement in activity with the introduction of a ferrocene nucleus among N-alkylazido-uracil precursors, with a preference for a bromo-substituent along with moderate chain lengths of n = 2-6. The reported protocol is a successful approach for integrating uracil-ferrocene-chalcone functionalities tethered via 1H-1,2,3-triazole rings with apparent physicochemical stability...
November 12, 2016: Chemical Biology & Drug Design
https://www.readbyqxmd.com/read/27852805/computational-properties-of-mitochondria-in-t-cell-activation-and-fate
#18
REVIEW
Roman Uzhachenko, Anil Shanker, Geneviève Dupont
In this article, we review how mitochondrial Ca(2+) transport (mitochondrial Ca(2+) uptake and Na(+)/Ca(2+) exchange) is involved in T cell biology, including activation and differentiation through shaping cellular Ca(2+) signals. Based on recent observations, we propose that the Ca(2+) crosstalk between mitochondria, endoplasmic reticulum and cytoplasm may form a proportional-integral-derivative (PID) controller. This PID mechanism (which is well known in engineering) could be responsible for computing cellular decisions...
November 2016: Open Biology
https://www.readbyqxmd.com/read/27852753/thermal-sensitivity-and-phenotypic-plasticity-of-cardiac-mitochondrial-metabolism-in-european-perch-perca-fluviatilis
#19
Andreas Ekström, Erik Sandblom, Pierre U Blier, Bernard-Antonin Dupont Cyr, Jeroen Brijs, Nicolas Pichaud
Cellular and mitochondrial metabolic capacity of the heart has been suggested to limit performance of fish at warm temperatures. We investigated this hypothesis by studying the effects of acute temperature increases (16, 23, 30, 32.5 and 36°C) on the thermal sensitivity of 10 key enzymes governing cardiac oxidative and glycolytic metabolism in two populations of European perch (Perca fluviatilis) field-acclimated to 15.5 and 22.5°C, as well as the effects of acclimation on cardiac lipid composition. In both populations of perch, the activity of glycolytic (pyruvate kinase and lactate dehydrogenase) and tricarboxylic acid cycle (pyruvate dehydrogenase and citrate synthase) enzymes increased with acute warming...
November 16, 2016: Journal of Experimental Biology
https://www.readbyqxmd.com/read/27842475/evaluation-of-antistigma-interventions-with-sixth-grade-students-a-school-based-field-experiment
#20
Kirstin Painter, Jo C Phelan, Melissa J DuPont-Reyes, Kay F Barkin, Alice P Villatoro, Bruce G Link
OBJECTIVE: School-based interventions for preadolescents provide the opportunity, in a ubiquitous institutional setting, to attack stigmatizing attitudes before they are firmly entrenched, and thus they may reduce mental illness stigma in the overall population. This study evaluated the effectiveness of classroom-based interventions in reducing stigma and increasing understanding of mental illness and positive attitudes toward treatment seeking among sixth-grade students. METHODS: In an ethnically and racially diverse sample (N=721), 40% of participants were Latino, 26% were white, and 24% were African American; the mean age was 11...
November 15, 2016: Psychiatric Services: a Journal of the American Psychiatric Association
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