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M Barbagallo, A Musumarra, L Cosentino, E Maugeri, S Heinitz, A Mengoni, R Dressler, D Schumann, F Käppeler, N Colonna, P Finocchiaro, M Ayranov, L Damone, N Kivel, O Aberle, S Altstadt, J Andrzejewski, L Audouin, M Bacak, J Balibrea-Correa, S Barros, V Bécares, F Bečvář, C Beinrucker, E Berthoumieux, J Billowes, D Bosnar, M Brugger, M Caamaño, M Calviani, F Calviño, D Cano-Ott, R Cardella, A Casanovas, D M Castelluccio, F Cerutti, Y H Chen, E Chiaveri, G Cortés, M A Cortés-Giraldo, S Cristallo, M Diakaki, C Domingo-Pardo, E Dupont, I Duran, B Fernandez-Dominguez, A Ferrari, P Ferreira, W Furman, S Ganesan, A García-Rios, A Gawlik, T Glodariu, K Göbel, I F Gonçalves, E González-Romero, E Griesmayer, C Guerrero, F Gunsing, H Harada, T Heftrich, J Heyse, D G Jenkins, E Jericha, T Katabuchi, P Kavrigin, A Kimura, M Kokkoris, M Krtička, E Leal-Cidoncha, J Lerendegui, C Lederer, H Leeb, S Lo Meo, S J Lonsdale, R Losito, D Macina, J Marganiec, T Martínez, C Massimi, P Mastinu, M Mastromarco, A Mazzone, E Mendoza, P M Milazzo, F Mingrone, M Mirea, S Montesano, R Nolte, A Oprea, A Pappalardo, N Patronis, A Pavlik, J Perkowski, M Piscopo, A Plompen, I Porras, J Praena, J Quesada, K Rajeev, T Rauscher, R Reifarth, A Riego-Perez, P Rout, C Rubbia, J Ryan, M Sabate-Gilarte, A Saxena, P Schillebeeckx, S Schmidt, P Sedyshev, A G Smith, A Stamatopoulos, G Tagliente, J L Tain, A Tarifeño-Saldivia, L Tassan-Got, A Tsinganis, S Valenta, G Vannini, V Variale, P Vaz, A Ventura, V Vlachoudis, R Vlastou, J Vollaire, A Wallner, S Warren, M Weigand, C Weiß, C Wolf, P J Woods, T Wright, P Žugec
The energy-dependent cross section of the ^{7}Be(n,α)^{4}He reaction, of interest for the so-called cosmological lithium problem in big bang nucleosynthesis, has been measured for the first time from 10 meV to 10 keV neutron energy. The challenges posed by the short half-life of ^{7}Be and by the low reaction cross section have been overcome at n_TOF thanks to an unprecedented combination of the extremely high luminosity and good resolution of the neutron beam in the new experimental area (EAR2) of the n_TOF facility at CERN, the availability of a sufficient amount of chemically pure ^{7}Be, and a specifically designed experimental setup...
October 7, 2016: Physical Review Letters
Vera Dinkelacker, Sophie Dupont, Séverine Samson
The new classification of epilepsy stratifies the disease into an acute level, based on seizures, and an overarching chronic level of epileptic syndromes (Berg et al., 2010). In this new approach, seizures are considered either to originate and evolve in unilateral networks or to rapidly encompass both hemispheres. This concept extends the former vision of focal and generalized epilepsies to a genuine pathology of underlying networks. These key aspects of the new classification can be linked to the concept of cognitive curtailing in focal epilepsy...
October 17, 2016: Epilepsy & Behavior: E&B
Isaac Molinero, Jordan Broman-Fulks, Michael J Lyons, Maria Gisele Matheus, Alka Chaubey, Barbara R DuPont, Michael J Friez, Steve A Skinner, Kenton R Holden
A focused genetic workup is useful in determining the cause of familial microcephaly, especially in the setting of mildly different phenotypes. As illustrated by this case from an impoverished international urban location, one must not assume the etiology for the apparent familial microcephaly is the same for all affected members.
October 2016: Clinical Case Reports
Lucille Arragain, Myrielle Dupont-Rouzeyrol, Olivia O'Connor, Nathalie Sigur, Jean-Paul Grangeon, Emilie Huguon, Clothilde Dechanet, Cécile Cazorla, Ann-Claire Gourinat, Elodie Descloux
: We investigated 10 mother-newborn pairs and found a 90% rate of dengue virus (DENV) transmission during the perinatal period. Here, we describe DENV kinetics in the sera of newborns before the onset of disease. Of the breast-milk samples analyzed, 75% tested positive for DENV. BACKGROUND: Dengue is the most common mosquito-borne viral disease in humans. With this study, we aimed to investigate the risk of vertical (DENV) transmission during the peripartum period and to describe its viral kinetics in serum and breast milk...
October 19, 2016: Journal of the Pediatric Infectious Diseases Society
Magali Dupont, Alice Ouachée, Juliette Royer, Corinne Dupuy
No abstract text is available yet for this article.
October 2016: Médecine Sciences: M/S
Mamatha Bhat, Peter Ghali, Benoît Dupont, Roy Hilzenrat, Mahmood Tazari, André Roy, Prosanto Chaudhury, Fernando Alvarez, Michel Carrier, Marc Bilodeau
BACKGROUND & AIMS: Patients listed with exception points for Hepatocellular carcinoma (HCC) have been more likely to be transplanted than those listed for chronic liver failure (LF) based on the Model for End-Stage Liver Disease (MELD) score. The aim of this study was to determine outcomes in the 5-year experience of a scoring system designed to reflect heterogeneity of tumor load of patients listed for HCC. METHODS: A novel MELD exception point system based on size and number of HCC was implemented in July 2009...
October 14, 2016: Journal of Hepatology
Philippe Montravers, Pierre-François Perrigault, Jean-François Timsit, Jean-Paul Mira, Olivier Lortholary, Olivier Leroy, Jean-Pierre Gangneux, Didier Guillemot, Caroline Bensoussan, Sébastien Bailly, Elie Azoulay, Jean-Michel Constantin, Hervé Dupont
OBJECTIVE: To compare the clinical characteristics and prognosis of patients treated for Candida peritonitis (CP), according to the type of systemic anti-fungal therapy (SAT), empiric (EAF) or targeted (TAF) therapies, and the final diagnosis of infection. METHODS: ICU patients treated for CP were selected among the AmarCAND2 cohort, to compare patients receiving EAF for not confirmed suspicion of CP (EAF/nonCP), to those with suspected secondarily confirmed CP (EAF/CP), or with primarily proven CP receiving TAF...
October 13, 2016: Clinical Microbiology and Infection
Isabelle Le Huërou-Luron, Karima Bouzerzour, Stéphanie Ferret-Bernard, Olivia Ménard, Laurence Le Normand, Cécile Perrier, Cindy Le Bourgot, Julien Jardin, Claire Bourlieu, Thomas Carton, Pascale Le Ruyet, Isabelle Cuinet, Cécile Bonhomme, Didier Dupont
PURPOSE: Although composition of infant formula has been significantly improved during the last decade, major differences with the composition and structure of breast milk still remain and might affect nutrient digestion and gut biology. We hypothesized that the incorporation of dairy fat in infant formulas could modify their physiological impacts by making their composition closer to that of human milk. The effect of milk fat and milk fat globule membrane (MFGM) fragments in infant formulas on gut digestion, mucosal immunity and microbiota composition was evaluated...
October 15, 2016: European Journal of Nutrition
J Caltagirone, A Dupont, M Afanetti, E Gondon, D Dupont
The vitamin B12 reserves of newborns are dependent on transplacental transfer and secondarily on food intake. This vitamin is involved in hematopoiesis and in neurological development. We report the case of a severe vitamin B12 deficiency in a 7-month-old infant. A neurological evaluation performed at 5 months of age for psychomotor regression found nonspecific cortical atrophy. The infant was hospitalized for impaired general condition and worsening of neurological symptoms. Examinations revealed bicytopenia with normocytic anemia (Hb: 7...
October 12, 2016: Archives de Pédiatrie: Organe Officiel de la Sociéte Française de Pédiatrie
Janus Adler Hyldebrandt, Nicolaj Brejnholt Støttrup, Christian Alcaraz Frederiksen, Johan Heiberg, Rune Isak Dupont Birkler, Mogens Johannsen, Michael Rahbek Schmidt, Hanne Berg Ravn
OBJECTIVES: Myocardial infarction and chronic heart failure induce specific metabolic changes in the neonatal myocardium that are closely correlated to outcome. The aim of this study was to examine the metabolic responses to noninfarct heart failure and inotropic treatments in the newborn heart, which so far are undetermined. DESIGN: A total of 28 newborn pigs were instrumented with a microdialysis catheter in the right ventricle, and intercellular citric acid cycle intermediates and adenosine metabolite concentrations were determined at 20-minute intervals...
October 12, 2016: Pediatric Critical Care Medicine
Benjamin De Leener, Simon Lévy, Sara M Dupont, Vladimir S Fonov, Nikola Stikov, D Louis Collins, Virginie Callot, Julien Cohen-Adad
For the past 25 years, the field of neuroimaging has witnessed the development of several software packages for processing multi-parametric magnetic resonance imaging (mpMRI) to study the brain. These software packages are now routinely used by researchers and clinicians, and have contributed to important breakthroughs for the understanding of brain anatomy and function. However, no software package exists to process mpMRI data of the spinal cord. Despite the numerous clinical needs for such advanced mpMRI protocols (multiple sclerosis, spinal cord injury, cervical spondylotic myelopathy, etc...
October 5, 2016: NeuroImage
C Van de Kerkhove, P C Goeminne, M Kicinski, T S Nawrot, N Lorent, P Van Bleyenbergh, K De Boeck, L J Dupont
INTRODUCTION: The efficacy of inhaled antibiotics to treat chronic Pseudomonas aeruginosa pulmonary infection in patients with cystic fibrosis (CF) has been well established. Few data are available on the value of continuous alternating inhaled antibiotic therapy (CAIT), a strategy increasingly used in the management of CF. OBJECTIVE: To investigate the effect of CAIT on clinical outcome in adult CF patients treated at the University Hospital Leuven. METHODS: Patients with a documented CF diagnosis who received inhaled antibiotics between March 2010 and January 2015 were retrospectively evaluated...
October 5, 2016: Journal of Cystic Fibrosis: Official Journal of the European Cystic Fibrosis Society
Julien Mysoet, Marie-Hélène Canu, Christophe Gillet, Julie Fourneau, Cyril Garnier, Bruno Bastide, Erwan Dupont
Immobilization, bed rest, or sedentary lifestyle, are known to induce a profound impairment in sensorimotor performance. These alterations are due to a combination of peripheral and central factors. Previous data conducted on a rat model of disuse (hindlimb unloading, HU) have shown a profound reorganization of motor cortex and an impairment of motor performance. Recently, our interest was turned towards the role of insulin-like growth factor 1 (IGF-1) in cerebral plasticity since this growth factor is considered as the mediator of beneficial effects of exercise on the central nervous system, and its cortical level is decreased after a 14-day period of HU...
October 4, 2016: Behavioural Brain Research
Pieter Martens, Frederik H Verbrugge, Petra Nijst, Matthias Dupont, Wilfried Mullens
BACKGROUND: Cardiac resynchronization therapy (CRT) improves morbidity and mortality in heart failure with reduced ejection fraction (HFrEF) and electrical dyssynchrony. CRT patients in clinical practice are older compared to clinical trials. OBJECTIVE: To investigate clinical response, reverse remodeling, outcome and mode of death in octogenarians receiving CRT. METHODS: Baseline characteristics, change in New York Heart Association (NYHA) functional class, reverse ventricular remodeling, heart failure readmissions, all-cause mortality and mode of death were evaluated in CRT patients with comparison between octogenarians and non-octogenarians...
October 4, 2016: Journal of Cardiac Failure
Wassim Moalla, Mohamed Saifeddin Fessi, Fayçal Farhat, Sabeur Nouira, Del P Wong, Grégory Dupont
We studied the relationship between daily training load (TL) experienced by professional soccer players and the Hooper questionnaire reflecting their perceived quality of sleep, fatigue, stress and delayed onset muscle soreness. During a 16-week training period, the rating of perceived exertion and duration were collected after each training session, and daily TL was calculated from 14 professional soccer players. The Hooper questionnaire was completed every day before the first training session and the Hooper's score (HS) was then calculated...
October 7, 2016: Research in Sports Medicine
Valeriia Grigel, Dorian Dupont, Kim De Nolf, Zeger Hens, Mickael D Tessier
Despite their various potential applications, InAs colloidal quantum dots have attracted considerably less attention than more classical II-VI materials because of their complex syntheses that require hazardous precursors. Recently, amino-phosphine has been introduced as a cheap, easy-to-use and efficient phosphorus precursor to synthesize InP quantum dots. Here, we use aminopnictogen precursors to implement a similar approach for synthesizing InAs quantum dots. We develop a two-step method based on the combination of aminoarsine as the arsenic precursor and aminophosphine as the reducing agent...
October 5, 2016: Journal of the American Chemical Society
Jennifer L Weidhaas, Andrea M Dietrich, Nathan J DeYonker, R Ryan Dupont, William T Foreman, Daniel Gallagher, Jennifer E G Gallagher, Andrew J Whelton, William A Alexander
Chemical spills and accidents contaminate the environment and disrupt societies and economies around the globe. In the United States there were approximately 172,000 chemical spills that affected US waterbodies from 2004 to 2014. More than 8000 of these spills involved non-petroleum-related chemicals. Traditional emergency responses or incident command structures (ICSs) that respond to chemical spills require coordinated efforts by predominantly government personnel from multiple disciplines, including disaster management, public health, and environmental protection...
September 2016: Journal of Environmental Quality
Pierre De Wit, Sam Dupont, Peter Thor
Ocean acidification is expected to have dramatic impacts on oceanic ecosystems, yet surprisingly few studies currently examine long-term adaptive and plastic responses of marine invertebrates to pCO 2 stress. Here, we exposed populations of the common copepod Pseudocalanus acuspes to three pCO 2 regimes (400, 900, and 1550 μatm) for two generations, after which we conducted a reciprocal transplant experiment. A de novo transcriptome was assembled, annotated, and gene expression data revealed that genes involved in RNA transcription were strongly down-regulated in populations with long-term exposure to a high pCO 2 environment, even after transplantation back to control levels...
October 2016: Evolutionary Applications
Piero Calosi, Pierre De Wit, Peter Thor, Sam Dupont
Projections of marine biodiversity and implementation of effective actions for its maintenance in the face of current rapid global environmental change are constrained by our limited understanding of species' adaptive responses, including transgenerational plasticity, epigenetics and natural selection. This special issue presents 13 novel studies, which employ experimental and modelling approaches to (i) investigate plastic and evolutionary responses of marine species to major global change drivers; (ii) ask relevant broad eco-evolutionary questions, implementing multiple species and populations studies; (iii) show the advantages of using advanced experimental designs and tools; (iv) construct novel model organisms for marine evolution; (v) help identifying future challenges for the field; and (vi) highlight the importance of incorporating existing evolutionary theory into management solutions for the marine realm...
October 2016: Evolutionary Applications
Sebastien Elis, Alice Desmarchais, Sandrine Freret, Virginie Maillard, Valérie Labas, Juliette Cognié, Eric Briant, Celine Hivelin, Joëlle Dupont, Svetlana Uzbekova
The objective of this study was to determine whether fish oil supplement has an effect on adipose tissue lipid profiles and gene expression in postpartum dairy cows. Holstein cows were supplemented with either long-chain n-3 polyunsaturated fatty acid (PUFA; protected fish oil) or control PUFA (n-6; toasted soybeans) for 2 mo after calving (n = 23 per diet). These cows showed no difference in milk production or metabolic parameters, but exhibited a tendency toward a decrease in early embryo mortality rate after artificial insemination...
September 28, 2016: Journal of Dairy Science
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