keyword
MENU ▼
Read by QxMD icon Read
search

Round Up

keyword
https://www.readbyqxmd.com/read/28822205/comparison-of-effectiveness-of-two-different-artemisinin-based-combination-therapies-in-an-area-with-high-seasonal-transmission-of-malaria-in-burkina-faso
#1
Paul Sondo, Karim Derra, Seydou Diallo Nakanabo, Zekiba Tarnagda, Adama Kazienga, Innocent Valea, Herman Sorgho, Jean-Bosco Ouédraogo, Tinga Robert Guiguemdé, Halidou Tinto
In Sahelian countries such as Burkina Faso, malaria transmission is seasonal with a high incidence of transmission during the rainy season. This study aimed to compare the effectiveness of the two recommended treatments (Artemether-Lumefantrine and Artesunate-Amodiaquine) for uncomplicated malaria in Burkina Faso regarding this seasonal variation of malaria transmission. This is part of a randomized open label trial comparing the effectiveness and safety of Artemether-Lumefantrine versus Artesunate-Amodiaquine according to routine practice in Nanoro...
2017: Annals of Parasitology
https://www.readbyqxmd.com/read/28820477/lora-mobile-to-base-station-channel-characterization-in-the-antarctic
#2
Johnny Gaelens, Patrick Van Torre, Jo Verhaevert, Hendrik Rogier
Antarctic conditions demand that wireless sensor nodes are operational all year round and that they provide a large communication range of several tens of kilometers. LoRa technology operating in sub-GHz frequency bands implements these wireless links with minimal power consumption. The employed chirp spread spectrum modulation provides a large link budget, combined with the excellent radio-wave propagation characteristics in these bands. In this paper, an experimental wireless link from a mobile vehicle which transmits sensor data to a base station is measured and analyzed in terms of signal-to-noise ratio and packet loss...
August 18, 2017: Sensors
https://www.readbyqxmd.com/read/28816583/mammalian-cell-surface-display-for-monoclonal-antibody-based-facs-selection-of-viral-envelope-proteins
#3
Tim-Henrik Bruun, Veronika Grassmann, Benjamin Zimmer, Benedikt Asbach, David Peterhoff, Alexander Kliche, Ralf Wagner
The elicitation of broadly and efficiently neutralizing antibodies in humans by active immunization is still a major obstacle in the development of vaccines against pathogens such as the human immunodeficiency virus (HIV), influenza virus, hepatitis C virus or cytomegalovirus. Here, we describe a mammalian cell surface display and monoclonal antibody (mAb)-mediated panning technology that allows affinity-based selection of envelope (Env) variants from libraries. To this end, we established an experimental setup featuring: 1) single and site specific integration of Env to link genotype and phenotype, 2) inducible Env expression to avoid cytotoxicity effects, 3) translational coupling of Env and enhanced green fluorescent protein expression to normalize for Env protein levels, and 4) display on HEK cells to ensure native folding and mammalian glycosylation...
August 17, 2017: MAbs
https://www.readbyqxmd.com/read/28816121/research-round-up
#4
Seema Kang
No abstract text is available yet for this article.
July 2017: Lancet Psychiatry
https://www.readbyqxmd.com/read/28815425/methodological-study-of-vancomycin-dosing-in-elderly-patients-using-actual-serum-creatinine-versus-rounded-serum-creatinine
#5
Tramaine Young, Matt Daniel, Stephanie Baumhover, Duke Eidson, Jane Green
PURPOSE: The practice of intentional rounding up of serum creatinine (SCr) in elderly patients with low measured values can lead to an underestimation of creatinine clearance and subsequent inaccurate dosing of medications. Thus, the purpose of this study was to evaluate the accuracy of vancomycin dose calculations for patients aged ≥65 years using an SCr rounded up to 1 mg/dL versus actual SCr. METHODS: This study compared the difference between measured steady-state vancomycin trough concentrations with predicted trough concentrations that have been calculated using rounded SCr and actual SCr...
August 16, 2017: Drugs in R&D
https://www.readbyqxmd.com/read/28813505/allostatic-load-as-a-predictor-of-all-cause-and-cause-specific-mortality-in-the-general-population-evidence-from-the-scottish-health-survey
#6
Tony Robertson, Gayle Beveridge, Catherine Bromley
Allostatic load is a multiple biomarker measure of physiological 'wear and tear' that has shown some promise as marker of overall physiological health, but its power as a risk predictor for mortality and morbidity is less well known. This study has used data from the 2003 Scottish Health Survey (SHeS) (nationally representative sample of Scottish population) linked to mortality records to assess how well allostatic load predicts all-cause and cause-specific mortality. From the sample, data from 4,488 men and women were available with mortality status at 5 and 9...
2017: PloS One
https://www.readbyqxmd.com/read/28812168/a-wireless-pressure-sensor-for-continuous%C3%A2-monitoring-of-intraocular-pressure-in-conscious-animals
#7
Simon A Bello, Christopher L Passaglia
An important aspect of eye health in humans and animal models of human diseases is intraocular pressure (IOP). IOP is typically measured by hand with a tonometer, so data are sparse and sporadic and round-the-clock variations are not well characterized. Here we present a novel system for continuous wireless IOP and temperature measurement in small animals. The system consists of a cannula implanted in the anterior chamber of the eye connected to pressure sensing electronics that can be worn by rats or implanted in larger mammals...
August 15, 2017: Annals of Biomedical Engineering
https://www.readbyqxmd.com/read/28810979/women-veterans-a-population-at-risk-for-fibromyalgia-the-associations-between-fibromyalgia-symptoms-and-quality-of-life
#8
Rita F D'Aoust, Alicia Gill Rossiter, Amanda Elliott, Ming Ji, Cecile Lengacher, Maureen Groer
BACKGROUND: The Institute of Federal Health Care recently published an executive summary from a round table discussion indicating that active duty and retired female military personnel are at high risk for adverse health outcomes unique to military service including complications related to post-traumatic stress disorder (PTSD), unreported sexual trauma, and musculoskeletal problems. In 2008, the Institute of Medicine began to review, evaluate, and summarize the literature on health outcomes in Gulf War-deployed and found sufficient evidence of a causal relationship with PTSD and suggestive evidence of an association with fibromyalgia (FM)...
July 2017: Military Medicine
https://www.readbyqxmd.com/read/28806842/clowns-in-paediatric-surgery-less-anxiety-and-more-oxytocin-a-pilot-study
#9
Tabea Scheel, Dorothea Hoeppner, Anne Grotevendt, Winfried Barthlen
Background Hospital stays and medical interventions are accompanied by worries and anxiety in children and parents. Recent studies show that hospital clowns may reduce anxiety and enhance well-being. However, so far studies are based solely on subjective measures and clowns are usually not integrated in medical routine. With this pilot study, we aim to provide both psychological and physiological evidence of positive effects of clowns' interventions in hospitalized children. Patients/Method In a consecutive randomized intervention-control group design with 31 children aged 4 to 13 years, 17 patients were accompanied by a clown prior to surgery or during ward round (intervention group) and 14 were not (control group)...
August 14, 2017: Klinische Pädiatrie
https://www.readbyqxmd.com/read/28803485/raynaud-s-phenomenon-and-its-impact-on-activities-in-daily-life-during-one-year-of-follow-up-in-early-systemic-sclerosis
#10
G Sandqvist, P Wollmer, A Scheja, M Wildt, R Hesselstrand
OBJECTIVE: To investigate Raynaud's phenomenon (RP) and its impact on daily life activities during 1 year of follow-up in early systemic sclerosis (SSc). METHOD: Fourteen SSc patients with a median disease duration of 2 years were enrolled in the study. Every 7 weeks the patients completed a 7 day diary documenting the frequency and duration of RP attacks, the activity causing the attack, and how they handled the attack. The patients also recorded in the diary daily self-assessments of the difficulties with RP, using a 0-10 ordinal scale according to the Raynaud's Condition Score...
August 13, 2017: Scandinavian Journal of Rheumatology
https://www.readbyqxmd.com/read/28783548/influence-of-seasonality-and-vegetation-on-the-attenuation-of-emerging-contaminants-in-wastewater-effluent-dominated-streams-a-preliminary-study
#11
Víctor Matamoros, Yolanda Rodríguez
Treated wastewater from small communities is discharged into rivers or streams with a high biodiversity value. This is particularly important in Mediterranean countries, where most of the streams are dry almost all year round. This preliminary study assessed the occurrence and attenuation of 23 emerging contaminants (ECs) in 4 wastewater-dominated streams in which treated wastewater accounted for the entire stream flow. The concentration of ECs was monitored in the warm and cold seasons in the wastewater treatment plant (WWTP) effluent and at 6 downstream locations...
July 31, 2017: Chemosphere
https://www.readbyqxmd.com/read/28781812/non-neural-granular-cell-tumor-of-the-uterine-corpus-mimicking-uterine-leiomyoma-a-case-report
#12
Yoko Deguchi, Naoyuki Iwahashi, Yuko Horiuchi, Miwa Ikejima, Tomoyuki Tanaka, Kazuhiko Ino, Kenichi Furukawa
Non-neural granular cell tumors (GCTs) are clinically rare, whereas cases arising in the uterine corpus are exceedingly rare. Only three uterine cervical cases of GCTs have been reported to date and, to the best of our knowledge, there are no reports of GCT of the uterine corpus in the literature. We herein describe the first case of non-neural GCT arising from the uterine corpus reported to date. A 55-year-old premenopausal woman was referred to the Department of Obstetrics and Gynecology of Hashimoto Municipal Hospital (Wakayama, Japan) with a suspected uterine tumor...
September 2017: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/28775129/comprehensive-molecular-profiling-of-olfactory-neuroblastoma-identifies-potentially-targetable-fgfr3-amplifications
#13
Lorena Lazo de la Vega, Jonathan B McHugh, Andi K Cani, Komal Kunder, Frances M Walocko, Chia-Jen Liu, Daniel H Hovelson, Dan R Robinson, Arul M Chinnaiyan, Scott A Tomlins, Paul W Harms
Olfactory neuroblastomas (ONBs), also known as esthesioneuroblastomas, are malignant round-cell tumors that represent up to 5% of sinonasal malignancies. Despite their aggressive course, molecular studies of ONBs have been limited, and targeted therapies are lacking. To identify potential oncogenic drivers and targetable pathways in ONBs, we characterized 20 ONBs, including archived ONBs profiled by targeted, multiplexed PCR (mxPCR) based DNA next generation sequencing (NGS) of the coding sequence of over 400 cancer-relevant genes (n=16), mxPCR based RNA NGS of 108 target genes (n=15), and two ONBs profiled by comprehensive hybrid-capture based clinical grade NGS of >1,500 genes...
August 3, 2017: Molecular Cancer Research: MCR
https://www.readbyqxmd.com/read/28773081/a-validation-approach-for-quasistatic-numerical-experimental-indentation-analysis-in-soft-materials-using-3d-digital-image-correlation
#14
Luis Felipe-Sesé, Elías López-Alba, Benedikt Hannemann, Sebastian Schmeer, Francisco A Diaz
A quasistatic indentation numerical analysis in a round section specimen made of soft material has been performed and validated with a full field experimental technique, i.e., Digital Image Correlation 3D. The contact experiment specifically consisted of loading a 25 mm diameter rubber cylinder of up to a 5 mm indentation and then unloading. Experimental strains fields measured at the surface of the specimen during the experiment were compared with those obtained by performing two numerical analyses employing two different hyperplastic material models...
June 28, 2017: Materials
https://www.readbyqxmd.com/read/28771236/the-cubicon-method-for-concentrating-membrane-proteins-in-the-cubic-mesophase
#15
Pikyee Ma, Dietmar Weichert, Luba A Aleksandrov, Timothy J Jensen, John R Riordan, Xiangyu Liu, Brian K Kobilka, Martin Caffrey
The lipid cubic phase (in meso) method is an important approach for generating crystals and high-resolution X-ray structures of integral membrane proteins. However, as a consequence of instability, it can be impossible-using traditional methods-to concentrate certain membrane proteins and complexes to values suitable for in meso crystallization and structure determination. The cubicon method described here exploits the amphiphilic nature of membrane proteins and their natural tendency to partition preferentially into lipid bilayers from aqueous solution...
September 2017: Nature Protocols
https://www.readbyqxmd.com/read/28768680/improving-specialist-palliative-care-in-residential-care-for-older-people-a-checklist-to-guide-practice
#16
Liz Forbat, Michael Chapman, Clare Lovell, Wai-Man Liu, Nikki Johnston
OBJECTIVES: Palliative care needs rounds are triage meetings that have been introduced in residential care for older adults to help identify and prioritise care for people most at risk for unplanned dying with inadequately controlled symptoms. This study sought to generate an evidence-based checklist in order to support specialist palliative care clinicians integrate care in residential nursing homes for older people. METHODS: A grounded theory ethnographic study, involving non-participant observation and qualitative interviews...
August 2, 2017: BMJ Supportive & Palliative Care
https://www.readbyqxmd.com/read/28760848/comprehensive-arrayed-transposon-mutant-library-of-klebsiella-pneumoniae-outbreak-strain-kpnih1
#17
Beth Ramage, Roxanne Erolin, Kiara Held, Joe Gasper, Eli Weiss, Mitch Brittnacher, Larry Gallagher, Colin Manoil
Klebsiella pneumoniae and other carbapenem-resistant Enterobacteriaceae are a major cause of hospital-acquired infections, yet the basis of their success as nosocomial pathogens is poorly understood. To help provide a foundation for genetic analysis of K. pneumoniae, we created an arrayed, sequence-defined transposon mutant library of an isolate from the 2011 outbreak of infections at the U.S. National Institutes of Health Clinical Center. The library is made up of 12,000 individually arrayed mutants of a carbapenemase deletion parent strain and provides coverage of 85% of predicted genes...
July 31, 2017: Journal of Bacteriology
https://www.readbyqxmd.com/read/28760383/association-between-concentrations-of-hemoglobin-determined-by-fecal-immunochemical-tests-and-long-term-development-of-advanced-colorectal-neoplasia
#18
Esmée J Grobbee, Eline H Schreuders, Bettina E Hansen, Marco J Bruno, Iris Lansdorp-Vogelaar, Manon C W Spaander, Ernst J Kuipers
BACKGROUND & AIMS: Colorectal cancer (CRC) screening using quantitative fecal immunochemical tests (FITs) is rapidly gaining ground worldwide. FITs are invariably used in a dichotomous manner using pre-specified cut-off values. To optimize FIT-based screening programs, we investigated the association between fecal hemoglobin (fHb) concentrations below the FIT cut-off value and later development of colorectal advanced neoplasia. METHODS: We analyzed data collected from a population-based study of 9561 average-risk subjects (50-74 yrs old) in the Netherlands who were offered 4 rounds of FIT screening for CRC from November 2006 through December 2014...
July 28, 2017: Gastroenterology
https://www.readbyqxmd.com/read/28755459/defining-definitions-a-delphi-study-to-develop-a-core-outcome-set-for-conditions-of-severe-maternal-morbidity
#19
T Schaap, K Bloemenkamp, C Deneux-Tharaux, M Knight, J Langhoff-Roos, E Sullivan, T van den Akker
OBJECTIVE: Develop a core outcome set of international consensus definitions for severe maternal morbidities. DESIGN: Electronic Delphi study. SETTING: International. POPULATION: Eight expert panels. METHODS: All 13 high-income countries represented in the International Network of Obstetric Surveillance Systems (INOSS) nominated five experts per condition of morbidity, who submitted possible definitions...
July 29, 2017: BJOG: An International Journal of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/28755075/rheumatoid-arthritis-associated-spinal-neuroarthropathy-with-double-level-isthmic-spondylolisthesis
#20
Sang-Il Kim, Young-Hoon Kim, Jae-Won Lee, Won-Woo Kang, Kee-Yong Ha
INTRODUCTION: To the best of our knowledge, there has been no report regarding rheumatoid arthritis associated with spinal neuroarthropathy and combined double-level isthmic spondylolisthesis. Here, we report a rare case of spinal neuroarthropathy with double-level isthmic spondylolisthesis in a rheumatoid arthritis (RA) patient. A 56-year-old female patient under medical treatment for RA during the last 13 years presented aggravating radiating pain to her right lower extremity and a limping gait developed 4 months ago...
July 28, 2017: European Spine Journal
keyword
keyword
87644
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"