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Bo Hwa Choi, Mi Young Kim, So Dug Lim, Jung-Hyun Yang, Ji Young Ha, Nami Choi
RATIONALE: Poroid hidradenoma (PH) is a rare variant of benign sweat gland neoplasm without connection to the epidermis. This tumor presents clinically as a solitary lesion with a cystic component located in the subcutaneous layer abutting the skin. On ultrasound, it appears as a circumscribed complex cystic and solid mass abutting the dermis. The occurrence of PH in the breast is very rare. Its features overlap with intraductal papilloma and papillary carcinoma. PATIENT CONCERNS: A 66-year-old woman presented with a palpable lump in her right breast...
June 2018: Medicine (Baltimore)
Guangxue Li, Lan Mu, Ye Bi, Kai Yang, Yan Liu, Zhe Peng, Yi Zhu, Huiran Zang, Saisai Cao, Peiyang Zhang, Youlei Qian
INTRODUCTION: The Pacman flap is a novel modality for repairing round soft-tissue defects after tumor resection. This modality provides a robust blood supply without microsurgical tissue rearrangement. This article reviews the authors' experience with Pacman flap for reconstruction of round soft-tissue defects. The safety and effectiveness of the Pacman flap are investigated. METHODS: Here, we describe a method for oncologic reconstruction of round soft-tissue defects with a Pacman flap after tumor resection...
June 2018: Medicine (Baltimore)
Renhua Wu, Nanwei Tong, Xinlei Chen, Shishi Xu, Fang Zhang, Lizhi Tang, Yuwei Zhang
RATIONALE: Pheochromocytomas are rare catecholamine-secreting tumors arising from adrenomedullary chromaffin cells, usually causing hypertension, palpitation and headache. However, pheochromocytoma crisis, on the contrary, might present with hypotension, multiple organ dysfunction or even mimicking other diseases, leaving physician with diagnostic difficulties. In this study, we present a case featured hypotension, shock and multiple organ dysfunction syndrome on admission, which nearly lead us to miss the diagnosis of pheochromocytoma...
June 2018: Medicine (Baltimore)
Kamal Mtanes, Michael Mimouni, Shiri Zayit-Soudry
PURPOSE: To describe the clinical findings in patients with laser-induced retinal injury. METHODS: Consecutive patients presenting to a tertiary center between January 2014 and December 2015 following inadvertent ocular exposure to a laser pointer were included. Evaluation included a full ophthalmic examination and spectral-domain optical coherence tomography (SD-OCT). RESULTS: Seven young patients (8 eyes) were identified. Their mean age was 18...
June 18, 2018: Journal of Pediatric Ophthalmology and Strabismus
Abel Gonzalez, Dardo Etchichury
INTRODUCTION: Lower lip reconstruction should restore oral competence, speech, and cosmesis. These goals are a challenge when reparing large lower lip defects. Karapandzic flap is a reliable technique with consistent functional and esthetic outcome. In large defects, it might result in disproportion between the upper and lower lips and blunting of the commissures. The Abbe flap is useful as a lip balancing procedure and avoids the rounding of the commissures. PATIENTS AND METHODS: Five cases of lower lip skin cancer treated with Mohs surgery with defects up to 80% were reconstructed with a combination of Karapandzic and Abbe flaps...
June 13, 2018: Annals of Plastic Surgery
(no author information available yet)
No abstract text is available yet for this article.
June 1, 2018: Bulletin of the World Health Organization
Jesse W Williams, Catherine Martel, Stephane Potteaux, Ekaterina Esaulova, Molly A Ingersoll, Andrew Elvington, Brian T Saunders, Li-Hao Huang, Andreas J Habenicht, Bernd H Zinselmeyer, Gwendalyn J Randolph
OBJECTIVE: Macrophages play important roles in the pathogenesis of atherosclerosis, but their dynamics within plaques remain obscure. We aimed to quantify macrophage positional dynamics within progressing and regressing atherosclerotic plaques. APPROACH AND RESULTS: In a stable intravital preparation, large asymmetrical foamy macrophages in the intima of carotid artery plaques were sessile, but smaller rounded cells nearer plaque margins, possibly newly recruited monocytes, mobilized laterally along plaque borders...
June 14, 2018: Arteriosclerosis, Thrombosis, and Vascular Biology
Maham Hayat, Sultan Mahmood, John T Maple
A 62-year-old male with long-standing esophageal reflux underwent endoscopy at an outside institution that reported multiple polypoid lesions in upper esophagus and a small focal area of nodular mucosa at the gastroesophageal junction(GEJ). Biopsies of the proximal esophageal polyps demonstrated hyperplastic mucosa with ulceration, reactive epithelial changes, and focal intestinal metaplasia. Biopsies from the nodular GEJ mucosa were described as Barrett's esophagus with low grade dysplasia. An upper endoscopy performed at our medical center found multiple semi-pedunculated esophageal polyps between 18-24 cm from the incisors (Figure A)...
June 11, 2018: Clinical Gastroenterology and Hepatology
Richard M Fakin, Simon Zimmermann, Kai Kaye, Lukas Lunger, Geraldine Weinforth, Pietro Giovanoli
Background: Breast augmentation in trans-women requires special consideration and thorough preoperative planning. Objectives: This study aimed to present our long-term outcome and experience gained over the past 21 years. Methods: Trans-women who have undergone breast augmentation since 1995 were reviewed for primary surgery, type of incision, implant site, implant size & shape, and revisions. Results: A total of 138 patients with a follow-up of 4...
June 12, 2018: Aesthetic Surgery Journal
Matteo Allegretti, Beatrice Casini, Chiara Mandoj, Stefania Benini, Laurent Alberti, Mariangela Novello, Elisa Melucci, Laura Conti, Renato Covello, Edoardo Pescarmona, Giuseppe Maria Milano, Alessio Annovazzi, Vincenzo Anelli, Virginia Ferraresi, Roberto Biagini, Patrizio Giacomini
Background: Limited information is available on the applicative value of liquid biopsy (LB) in rare tumors, including Ewing's sarcoma (ES). The accepted precision diagnostics standards would greatly benefit from a non-invasive LB test monitoring pathognomonic gene rearrangements in the bloodstream. Methods: Tissue and blood samples were collected from six and four ES patients, respectively. Plasma was cleared by two successive rounds of centrifugation and stored frozen until RNA extraction by the QIAmp CNA kit...
2018: Therapeutic Advances in Medical Oncology
Hui Cai, Meisui Liu, Charles J Russell
Reporter viruses provide a powerful tool to study infection, yet incorporating a non-essential gene often results in virus attenuation and genetic instability. Here, we used directed evolution of a luciferase-expressing pandemic H1N1 (pH1N1) 2009 influenza A virus in mice to restore replication kinetics and virulence, increase the bioluminescence signal, and maintain reporter gene expression. An unadapted pH1N1 virus with NanoLuc luciferase inserted into the 5' end of the PA gene segment grew to titers 10-fold less than wild-type in MDCK cells and in DBA/2 mice and was less virulent...
June 13, 2018: Journal of Virology
Shaukat Khan, Mazhar Ul-Islam, Muhammad Ikram, Salman Ul Islam, Muhammad Wajid Ullah, Muhammad Israr, Jae Hyun Jang, Sik Yoon, Joong Kon Park
This study reports the fabrication of porogen-induced, surface-modified, 3-dimensionally microporous regenerated bacterial cellulose (rBC)/gelatin (3DMP rBC/G) scaffolds for skin regeneration applications. Round shaped gelatin microspheres (GMS), fabricated using a water-in-oil emulsion (WOE) method, were utilized as the porogen. The dissolution of GMS from the solution casted BC scaffolds led to surface-modified microporous rBC. The scaffolds were characterized using field emission scanning electron microscopy (FE-SEM) and elemental analysis...
June 9, 2018: International Journal of Biological Macromolecules
Shihui Wang, Qiuling Luo, Jia Liu, Liming Liu, Xiulai Chen
As a platform chemical, acetoin has a great potential of application in medicine and food industries. In order to improve the efficiency of acetoin production, Bacillus amyloliquefaciens was treated by atmospheric and room temperature plasma and gamma rays. Two-round screening was adopted for obtaining positive mutants, and the best mutant B. amyloliquefaciens H-5 produced acetoin up to 68.2 g/L in shake flask. Then, culture conditions were optimized in 5-L fermentor to enhance acetoin production. Finally, 85...
May 25, 2018: Sheng Wu Gong Cheng Xue Bao, Chinese Journal of Biotechnology
Alexander D Hernandez, Brian Boag, Roy Neilson, Naomi L Forrester
The myxoma virus (a microparasite) reduced wild rabbit numbers worldwide when introduced in the 1950s, and is known to interact with co-infecting helminths (macroparasites) causing both increases and decreases in macroparasite population size. In the 1990s Rabbit Haemorrhagic Disease Virus (RHDV) infected rabbits and also significantly reduced rabbit numbers in several countries. However, not much is known about RHDV interactions with macroparasites. In this study, we compare prevalence and intensity of infection for three gastrointestinal nematode species ( Trichostrongylus retortaeformis , Graphidium strigosum and Passalurus ambiguus ) before and after RHDV spread across host populations in Scotland and New Zealand...
August 2018: International Journal for Parasitology. Parasites and Wildlife
Grzegorz Łabuz, Timur M Yildirim, Thomas J T P van den Berg, Ramin Khoramnia, Gerd U Auffarth
PURPOSE: To assess the optical quality of intraocular lenses (IOLs) explanted because of opacification after the intraocular injection of gas. SETTING: David J. Apple Laboratory, Heidelberg, Germany. DESIGN: Experimental study. METHODS: Four hydrophilic acrylic IOLs were studied, each with a centrally localized round opacification pattern associated with the intraocular use of gas. Laboratory analysis included gross examination with a light microscope, followed by alizarin and von Kossa staining...
May 2018: Journal of Cataract and Refractive Surgery
Minh Quan Do, Evelynn Henry, Mallory Kato, Lionel Cheruzel
Cross-linked enzyme aggregate (CLEA) methodology has been applied to immobilize cytochrome P450 BM3 variants (F87A and 21B3) with peroxygenase activity. Several Ru(II)-diimine complexes were found to be suitable cross-linking agents, surpassing the traditional glutaraldehyde and dextran aldehyde. They offer modular numbers of aldehyde functionalities and a more rigid framework than their organic counterparts. The F87A CLEAs display significant activity loss compared to the protein in solution. Meanwhile, for the 21B3 CLEAs, high activity recovery (up to 95%) is obtained...
June 5, 2018: Journal of Inorganic Biochemistry
Hye Yin Park, Yun-Chul Hong, Ichiro Kawachi, Juhwan Oh
BACKGROUND: While controversies on limitation of coverage by the national health insurance and relatively high direct or "out-of-pocket" household payments by the national health insurance in South Korea still remain, potential unfavorable influence of the insufficiency of the universal health coverage on depression has not yet been evaluated. METHODS AND FINDINGS: Baseline information were obtained from a community cohort (The Korean Genome and Epidemiology Study) of middle-aged subjects without depression at enrollment period (2001-2002)...
2018: PloS One
Thomas Frieling
Background: Non-cardiac chest pain (NCCP) is recurrent angina pectoris-like pain without evidence of coronary heart disease in conventional diagnostic evaluation. The prevalence of NCCP is up to 70% and may be detected (in this order) at all levels of the medical health care system (general practitioner, emergency department, chest pain unit, coronary care). Reduction of quality of life due to NCCP is comparable, and partially even higher, to that caused by cardiac chest pain. Reasons for psychological strain are symptom recurrence in approximately 50%, nonspecific diagnosis with resulting uncertainty, and insufficient integration of other medical disciplines in the diagnostic workup...
April 2018: Visceral Medicine
Noelia Sanmamed, Alejandro Berlin, Akbar Beiki-Ardakani, Heather Ballantyne, Anna Simeonov, Peter Chung
Management options for locally recurrent sarcoma of the pelvis in patients previously treated with external beam radiation and surgery are limited. Pelvic exenteration is often the only viable but unattractive option. We present a patient with recurrent myxoid round cell liposarcoma of the ischiorectal fossa treated in 2013 with preoperative radiation (50 Gy in 25 fractions) and subsequent wide local resection. Four years later, a follow-up magnetic resonance imaging (MRI) scan demonstrated a 1 x 1 cm T2 hypointense soft tissue pre-sacral nodule consistent with local recurrence (LR)...
April 10, 2018: Curēus
Jörg Feldmann, Katharina Bluemlein, Eva Maria Krupp, Martin Mueller, Barry Alan Wood
This chapter is focussing on the interaction of arsenic, mercury and selenium with plans. Aspects of biotransformations are discussed, before the analytical methodologies are listed and critically appraised in the second part. A holistic view is given, starting from the soil environment and continuing to the plant roots and the translocations into the upper part of the plants. Under different soil conditions, different kinds of elemental species are identified, which have an impact on how the elemental species are taken up by the plant...
2018: Advances in Experimental Medicine and Biology
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