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https://www.readbyqxmd.com/read/29026821/comparison-of-resorbable-mesh-poly-l-lactide-glycolic-acid-and-porous-polyethylene-in-orbital-floor-fractures-in-an-experimental-model
#1
Ali Mubin Aral, Selahattin Özmen, Safak Uygur, Basar Kaya, Neslihan Coskun, Suna Ömeroglu, Koray Kılıc
BACKGROUND: Resorbable mesh and porous polyethylene are frequently used alloplastic materials for the treatment of the orbital blowout fractures. The literature lacks reports comparing their long-term effects on experimental models. OBJECTIVE: Our aim was to radiologically and histologically evaluate the effectiveness and safety of porous polyethylene and resorbable mesh in a rabbit orbital blowout fracture model. METHODS: Twelve New Zealand white rabbits (24 orbits) were randomized to 4 groups...
August 2017: Plastic Surgery
https://www.readbyqxmd.com/read/29023489/spatiotemporal-variations-in-gene-expression-histology-and-biomechanics-in-an-ovine-model-of-tendinopathy
#2
Sara Biasutti, Andrew Dart, Margaret Smith, Carina Blaker, Elizabeth Clarke, Leo Jeffcott, Christopher Little
Flexor tendinopathy is a common problem affecting humans and animals. Tendon healing is poorly understood and the outcomes of conservative and surgical management are often suboptimal. While often considered a localized injury, recent evidence indicates that in the short term, tendinopathic changes are distributed widely throughout the tendon, remote from the lesion itself. Whether these changes persist throughout healing is unknown. The aim of this study was to document gene expression, histopathological and biomechanical changes that occur throughout the superficial digital flexor tendon (SDFT) up to 16 weeks post-injury, using an ovine surgical model of tendinopathy...
2017: PloS One
https://www.readbyqxmd.com/read/29022703/probing-the-eumelanin-silica-interface-in-chemically-engineered-bulk-hybrid-nanoparticles-for-targeted-subcellular-antioxidant-protection
#3
Brigida Silvestri, Giuseppe Vitiello, Giuseppina Luciani, Vincenzo Calcagno, Aniello Costantini, Maria Gallo, Silvia Parisi, Simona Paladino, Mariagrazia Iacomino, Gerardino D'Errico, Maria Federica Caso, Alessandro Pezzella, Marco d'Ischia
We disclose herein the first example of stable monodispersed hybrid nanoparticles (termed MelaSil-NPs) made up of eumelanin biopolymer intimately integrated into a silica nanoscaffold matrix and endowed with high antioxidant and cytoprotective effects associated with a specific subcellular localization. MelaSil-NPs have been fabricated by an optimized sol-gel methodology involving ammonia-induced oxidative polymerization of a covalent conjugate of the eumelanin building block 5,6-dihydroxyindole-2-carboxylic acid (DHICA) with 3-aminopropyltriethoxysilanes (APTS)...
October 12, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29022056/implant-strategy-affects-scaffold-stability-and-integrity-in-cartilage-treatment
#4
M Drobnic, Francesco Perdisa, E Kon, F Cefalì, M Marcacci, G Filardo
PURPOSE: To identify the most appropriate implantation strategy for a novel chondral scaffold in a model simulating the early post-operative phase, in order to optimize the implant procedure and reduce the risk of early failure. METHODS: Eight human cadaveric limbs were strapped to a continuous passive motion device and exposed to extension-flexion cycles (0°-90°). Chondral lesions (1.8 cm diameter) were prepared on condyles, patella and trochlea for the implant of a bi-layer collagen-hydroxyapatite scaffold...
October 11, 2017: Knee Surgery, Sports Traumatology, Arthroscopy: Official Journal of the ESSKA
https://www.readbyqxmd.com/read/29021984/mri-findings-of-early-stage-hyperacute-hemorrhage-causing-extramedullary-compression-of-the-cervical-spinal-cord-in-a-dog-with-suspected-steroid-responsive-meningitis-arteritis
#5
Adriano Wang-Leandro, Enrice-Ina Huenerfauth, Katharina Heissl, Andrea Tipold
A 9-month-old female Weimaraner was presented to the emergency service due to episodes of fever and neck pain. Physical examination revealed a stiff neck posture and elevated body temperature. Shortly after clinical examination was performed, the dog developed peracute onset of non-ambulatory tetraparesis compatible with a C1-C5 spinal cord (SC) lesion. Immediately thereafter (<1 h), MRI of the cervical SC was performed with a 3-T scanner. A left ventrolateral intradural-extramedullary SC compression caused by a round-shaped structure at the level of C3--C4 was evidenced...
2017: Frontiers in Veterinary Science
https://www.readbyqxmd.com/read/29021188/is-follow-up-chest-x-ray-required-in-children-with-round-pneumonia
#6
Patrick McCrossan, Benjamin McNaughten, Michael Shields, Andrew Thompson
No abstract text is available yet for this article.
October 11, 2017: Archives of Disease in Childhood
https://www.readbyqxmd.com/read/29020432/acquired-nonpigmented-vitreous-cyst-associated-with-lattice-degeneration
#7
Jing Lu, Guiying Mai, Ruyuan Liu, Yan Luo, Lin Lu
A 63-year-old male presented with a round-shaped floater and visual obscuration in the right eye. Clinical evaluation showed a nonpigmented vitreous cyst connected to a lattice degeneration by a stalk. Immunostaining of the vitreous cyst obtained from vitrectomy showed its origin of retinal neuroepithelium. The cyst was formed by continuous vitreous traction, which might tear up the disrupted retina at the area of lattice degeneration. This report added the lattice degeneration to the list of causes for the acquired vitreous cyst...
October 1, 2017: Ophthalmic Surgery, Lasers & Imaging Retina
https://www.readbyqxmd.com/read/29020299/lifestyle-in-population-based-colorectal-cancer-screening-over-2-year-follow-up
#8
Sanni Helander, Sirpa Heinävaara, Tytti Sarkeala, Nea Malila
Background: Colorectal cancer (CRC) screening may cause changes in health-related lifestyle. In 2010, Finnish Mass Screening Registry began a study on psychosocial effects of CRC screening. This article examines whether there are differential developments in self-reported lifestyle at ages 59-61 years among CRC screening invitees and non-contacted controls. Methods: A population-based random sample of 10 648 Finnish adults born in 1951 and living in the municipalities voluntary involved in the CRC screening programme were sent a lifestyle questionnaire in 2010...
September 15, 2017: European Journal of Public Health
https://www.readbyqxmd.com/read/28994275/combined-adenosquamous-and-large-cell-neuroendocrine-carcinoma-of-the-gallbladder
#9
Jiyoon Jung, Yang-Seok Chae, Chul Hwan Kim, Youngseok Lee, Jeong Hyeon Lee, Dong-Sik Kim, Young-Dong Yu, Joo Young Kim
Large cell neuroendocrine carcinoma (LCNEC) of the gallbladder is extremely rare and usually combined with other type of malignancy, mostly adenocarcinoma. We report an unusual case of combined adenosquamous carcinoma and LCNEC of the gallbladder in a 54-year-old woman. A radical cholecystectomy specimen revealed a 4.3×4.0 cm polypoid mass in the fundus with infiltration of adjacent liver parenchyma. Microscopically, the tumor consisted of two distinct components. Adenosquamous carcinoma was predominant and abrupt transition from adenocarcinoma to squamous cell carcinoma was observed...
October 5, 2017: Journal of Pathology and Translational Medicine
https://www.readbyqxmd.com/read/28992102/commentary-on-bedroom-light-exposure-at-night-and-the-incidence-of-depressive-symptoms-a-longitudinal-study-of-the-heijokyo-cohort-obayashi-et-al
#10
Brant P Hasler
In modern society, we are increasingly disconnected from natural light/dark cycles and beset by round-the-clock exposure to artificial light. Light has powerful effects on physical and mental health, in part via the circadian system, and thus the timing of light exposure dictates whether it is helpful or harmful. In their compelling paper, Obayashi and colleagues offer evidence that light at night can prospectively predict an elevated incidence of depressive symptoms in older adults. Strengths of the study include the longitudinal design and direct, objective assessment of light levels, as well as accounting for multiple plausible confounders during analyses...
July 31, 2017: American Journal of Epidemiology
https://www.readbyqxmd.com/read/28992036/associations-between-sedentary-behaviours-and-cognitive-function-cross-sectional-and-prospective-findings-from-the-uk-biobank
#11
Kishan Bakrania, Charlotte L Edwardson, Kamlesh Khunti, Stephan Bandelow, Melanie J Davies, Thomas Yates
We investigate the cross-sectional and prospective associations between different sedentary behaviours and cognitive function in a large sample of UK Biobank adults. Baseline data were available on 502,643 participants (years 2006-2010). Cognitive tests included prospective memory [n = 171,585 (baseline only)], visual-spatial memory [round 1 (n = 483,832); round 2 (n = 482,762)], fluid intelligence [n = 165,492], and short-term numeric memory [n = 50,370]. After a mean period of 5.3-years, between 12,091 and 114,373 participants also provided follow-up cognitive data...
July 13, 2017: American Journal of Epidemiology
https://www.readbyqxmd.com/read/28988454/awake-serial-intralesional-steroid-injections-without-surgery-as-a-novel-targeted-treatment-for-idiopathic-subglottic-stenosis
#12
Ramon A Franco, Inna Husain, Lindsay Reder, Paul Paddle
OBJECTIVES/HYPOTHESIS: The fibrotic/erythematous appearance of the subglottis in idiopathic subglottic stenosis (iSGS) hints that it might respond to repeated intralesional steroid treatment similar to keloids. STUDY DESIGN: Retrospective cohort study. METHODS: Thirteen iSGS subjects (six treated in-office with serial intralesional steroid injections [SILSI] versus seven treated endoscopically in the operating room [OR] followed by awake SILSI) between October 2011 and April 2017...
October 8, 2017: Laryngoscope
https://www.readbyqxmd.com/read/28988165/documenting-and-explaining-the-hiv-decline-in-east-zimbabwe-the-manicaland-general-population-cohort
#13
Simon Gregson, Owen Mugurungi, Jeffrey Eaton, Albert Takaruza, Rebecca Rhead, Rufurwokuda Maswera, Junior Mutsvangwa, Justin Mayini, Morten Skovdal, Robin Schaefer, Timothy Hallett, Lorraine Sherr, Shungu Munyati, Peter Mason, Catherine Campbell, Geoffrey P Garnett, Constance Anesu Nyamukapa
PURPOSE: The Manicaland cohort was established to provide robust scientific data on HIV prevalence and incidence, patterns of sexual risk behaviour and the demographic impact of HIV in a sub-Saharan African population subject to a generalised HIV epidemic. The aims were later broadened to include provision of data on the coverage and effectiveness of national HIV control programmes including antiretroviral therapy (ART). PARTICIPANTS: General population open cohort located in 12 sites in Manicaland, east Zimbabwe, representing 4 major socioeconomic strata (small towns, agricultural estates, roadside settlements and subsistence farming areas)...
October 6, 2017: BMJ Open
https://www.readbyqxmd.com/read/28984300/cd200-expression-in-mantle-cell-lymphoma-identifies-a-unique-subgroup-of-patients-with-frequent-ighv-mutations-absence-of-sox11-expression-and-an-indolent-clinical-course
#14
Zhihong Hu, Yi Sun, Ellen J Schlette, Guilin Tang, Shaoying Li, Jie Xu, C Cameron Yin, Ken H Young, Keyur Pravinchandra Patel, Roberto N Miranda, Maitrayee Goswami, Michael Wang, Jeffrey L Jorgensen, L Jeffrey Medeiros, Sa A Wang
CD200, a marker currently utilized in the diagnosis of B-cell lymphoma, is uniformly positive in chronic lymphocytic leukemia/chronic lymphocytic leukemia, and is usually absent in mantle cell lymphoma. Over a 6 year-period, of 668 mantle cell lymphoma assessed by flow cytometry, CD200 expression was detected in 25 patients (~4%). All 25 patients had bone marrow involvement; however, 11 (44%) patients had no nodal or extranodal disease and belonged to non-nodal leukemic variant mantle cell lymphoma. Morphologically, bone marrow showed an unusual interstitial infiltrative pattern in 14/25 (56%) and small round cells resembling chronic lymphocytic leukemia in 9/25 (36%)...
October 6, 2017: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
https://www.readbyqxmd.com/read/28984116/cerebellar-liponeurocytoma-with-atypical-histological-features-a-rare-example-of-a-glioneuronal-tumor
#15
Blanka Hermann, Michal Woznica, Wojciech Kloc, Piotr Borkowski, Witold Libionka, Ewa Izycka-Swieszewska
We present a case of a rare neoplasm in a 77-year-old woman with previous oncological history, who developed a rapid onset of cerebellar symptoms. The neuroimaging detected a posterior fossa tumor suspected of meningioma which was completely resected soon after. Histologically the neoplasm had two components with different immunophenotype. One constituent was lobular, composed of monotonous mitotically active round cells with a predominant neuronal profile. The second, astrocytic component contained lipomatous cells intermixed with larger gemistocytic astrocytes...
2017: Folia Neuropathologica
https://www.readbyqxmd.com/read/28983163/angioleiomyoma-of-uterus-masquerading-as-malignant-ovarian-tumor
#16
Sweta Singh, Monalisha Naik, Narbadyswari Deep Bag, Susama Patra
Uterine angioleiomyoma is rare. A 40-year-old nulliparous woman presented with heavy menstrual bleeding (HMB) for the past 2 years and mass per abdomen with severe dysmenorrhea for three cycles. She had received 8 units of packed cell transfusion outside. Clinical examination revealed a huge 32-week-sized abdominopelvic mass with irregular margins. Ultrasonography (USG) of the abdomen and pelvis showed a large solid cystic mass on the right side of the abdomen with a well-defined hypoechoeic rounded lesion of size 5...
July 2017: Journal of Mid-life Health
https://www.readbyqxmd.com/read/28981665/large-scale-delivery-of-seasonal-malaria-chemoprevention-to-children-under-10-in-senegal-an-economic-analysis
#17
Catherine Pitt, Mouhamed Ndiaye, Lesong Conteh, Ousmane Sy, El Hadj Ba, Badara Cissé, Jules F Gomis, Oumar Gaye, Jean-Louis Ndiaye, Paul J Milligan
Seasonal Malaria Chemoprevention (SMC) is recommended for children under 5 in the Sahel and sub-Sahel. The burden in older children may justify extending the age range, as has been done effectively in Senegal. We examine costs of door-to-door SMC delivery to children up to 10 years by community health workers (CHWs). We analysed incremental financial and economic costs at district level and below from a health service perspective. We examined project accounts and prospectively collected data from 405 CHWs, 46 health posts, and 4 district headquarters by introducing questionnaires in advance and completing them after each monthly implementation round...
November 1, 2017: Health Policy and Planning
https://www.readbyqxmd.com/read/28977976/clinical-features-and-prognosis-for-intraventricular-liponeurocytoma
#18
Nini Xu, Jinxiu Cai, Jiang Du, Rong Yang, Huachen Zhu, Peiyi Gao, Jian Zhou, Xiaofeng Li
Cerebellar liponeurocytoma is a rare central nervous system tumor, we investigate its biological behaviors and clinical prognosis to improve the understanding of this tumor. We retrospectively analyzed the clinical, radiological and histopathological findings as well as follow-up data of two patients with intraventricular liponeurocytomas in Beijing Tiantan Hospital between July 2000 and July 2016. The main clinical manifestations of the two patients were headache. The supratentorial intraventricular liponeurocytoma appeared as isodense to slight hyperdense on CT scan and heterogeneous intensity on T1-weighted imaging (T1WI) and T2-weighted imaging (T2WI)...
September 22, 2017: Oncotarget
https://www.readbyqxmd.com/read/28976545/a-novel-smaller-scaffold-for-affitins-showcase-with-binders-specific-for-epcam
#19
Valentina Kalichuk, Axelle Renodon-Cornière, Ghislaine Béhar, Federico Carrión, Gonzalo Obal, Mike Maillasson, Barbara Mouratou, Véronique Préat, Frédéric Pecorari
Affitins are highly stable engineered affinity proteins, originally derived from Sac7d and Sso7d, two 7 kDa DNA-binding polypeptides from Sulfolobus genera. Their efficiency as reagents for intracellular targeting, enzyme inhibition, affinity purification, immunolocalization and various other applications has been demonstrated. Recently, we have characterized the 7 kDa DNA-binding family, and Aho7c originating from Acidianus hospitalis was shown to be its smallest member with thermostability comparable to those of Sac7d and Sso7d...
October 4, 2017: Biotechnology and Bioengineering
https://www.readbyqxmd.com/read/28975895/pla-short-i-sub-micron-fibers-i-reinforcement-of-3d-bioprinted-alginate-constructs-for-cartilage-regeneration
#20
Alicja Kosik-Kozioł, Marco Costantini, Tomasz Bolek, Krisztina Szoke, Andrea Barbetta, Jan E Brinchmann, Wojciech Święszkowski
In this study, we present an innovative strategy to reinforce 3D printed hydrogel constructs for cartilage tissue engineering by formulating composite bioinks containing alginate and short sub-micron polylactide (PLA) fibers. We demonstrate that Young's modulus obtained for pristine alginate constructs (6.9 ± 1.7 kPa) can be increased threefold (up to 25.1 ± 3.8 kPa) with the addition of PLA short fibers. Furthermore, to assess the performance of such materials in cartilage tissue engineering, we loaded the bioinks with human chondrocytes and cultured in vitro the bioprinted constructs for up to 14 days...
October 4, 2017: Biofabrication
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