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https://www.readbyqxmd.com/read/29690620/silk-route-to-the-acceptance-and-re-implementation-of-bacteriophage-therapy-part-ii
#1
Wilbert Sybesma, Christine Rohde, Pavol Bardy, Jean-Paul Pirnay, Ian Cooper, Jonathan Caplin, Nina Chanishvili, Aidan Coffey, Daniel De Vos, Amber Hartman Scholz, Shawna McCallin, Hilke Marie Püschner, Roman Pantucek, Rustam Aminov, Jiří Doškař, D İpek Kurtbӧke
This perspective paper follows up on earlier communications on bacteriophage therapy that we wrote as a multidisciplinary and intercontinental expert-panel when we first met at a bacteriophage conference hosted by the Eliava Institute in Tbilisi, Georgia in 2015. In the context of a society that is confronted with an ever-increasing number of antibiotic-resistant bacteria, we build on the previously made recommendations and specifically address how the Nagoya Protocol might impact the further development of bacteriophage therapy...
April 23, 2018: Antibiotics
https://www.readbyqxmd.com/read/29690173/a-new-species-of-rhinogobius-pisces-gobiidae-with-analyses-of-its-dna-barcode
#2
Jian-Hong Xia, Han-Lin Wu, Chen-Hong Li, Yuan-Qi Wu, Su-Han Liu
The genus Rhinogobius Gill 1859 is widely distributed in fresh waters along the Western Pacific coast of tropical and temperate Asia. A new species, Rhinogobius maxillivirgatus, is described from Anhui Province in Eastern China. This species can be differentiated from all congeners by a combination of the following characters: up to 6 longitudinal brown to black stripes along the side of the body; pectoral-fin rays modally 14; predorsal scale series 5-9; lateral scale series 28-30; transverse scale series 6-7; branchiostegal membrane with about 20 red round spots in males; and 2 black oblique stripes parallel along the upper jaw on the anterior portion of the cheek...
April 12, 2018: Zootaxa
https://www.readbyqxmd.com/read/29689239/unmatched-integrated-cardiothoracic-surgery-program-applicants-where-do-they-end-up
#3
Trevor A Davis, Stephen C Yang
BACKGROUND: With the recent introduction of Integrated Cardiothoracic Surgery Residency Programs (IPs), limited data exists on unmatched applicants. We aimed to determine the dropout rate in individuals who applied IP but did not match. METHODS: An online IRB-approved survey was sent to current residents (n=409), provided by the Thoracic Surgery Directors Association, to evaluate preferences and pathway to Cardiothoracic Surgery (CTS). Descriptive analysis was performed on quantitative data...
April 21, 2018: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/29687753/cleaning-up-the-paper-trail-our-clinical-notes-in-open-view
#4
Gerard Lambe, Niall Linnane, Ian Callanan, Marcus W Butler
Purpose Ireland's physicians have a legal and an ethical duty to protect confidential patient information. Most healthcare records in Ireland remain paper based, so the purpose of this paper is to: assess the protection afforded to paper records; log highest risk records; note the variations that occurred during the working week; and observe the varying protection that occurred when staff, students and public members were present. Design/methodology/approach A customised audit tool was created using Sphinx software...
April 16, 2018: International Journal of Health Care Quality Assurance
https://www.readbyqxmd.com/read/29685543/homogeneous-myxoid-liposarcomas-mimicking-cysts-on-mri-a-challenging-diagnosis
#5
A Crombé, F Le Loarer, N Alberti, X Buy, E Stoeckle, S Cousin, M Toulmonde, J M Coindre, A Italiano, M Kind
OBJECTIVES: Myxoid liposarcoma (M-LPS) is the second most frequent subtype of liposarcoma. Foci of fat on MRI are strongly suggestive of this diagnosis. The aims of this study are to (i) assess the prevalence of perfectly homogeneous M-LPS-mimicking cyst and characterize their associated clinical and pathological features and to (ii) identify helpful clues to prevent misdiagnosis when encountered with a cyst-like lesion in soft tissue parts. METHODS: MR images from 32 consecutive pathologically proven M-LPS and round cell liposarcomas (RC-LPS) were retrospectively reviewed independently by two radiologists at our institution...
May 2018: European Journal of Radiology
https://www.readbyqxmd.com/read/29683143/a-field-observation-of-rotational-feeding-by-neogobius-melanostomus
#6
Ted R Angradi
Neogobius melanostomus , the round goby, was recorded by underwater video feeding on crushed dreissenid mussels at a depth of 12 m in Georgian Bay of Lake Huron, a Laurentian Great Lake. In the video, gobies used rotational or twist feeding to tear away particles from crushed mussels. At least 43 examples of this feeding maneuver occur in the video. Up to 120 gobies m-2 were visible at a time in the video. Mean standard length of gobies appearing in the video was 37 mm. Mean standard length of fish exhibiting twist feeding was larger, 48 mm...
January 22, 2018: Fishes
https://www.readbyqxmd.com/read/29679895/ingredientes-farmac%C3%A3-uticos-activos-potencialmente-inapropiados-en-adultos-mayores-lista-ifaspiam-panel-de-consenso-argentino
#7
Marta M Marzi, Miryam S Pires, Nora B Quaglia
OBJECTIVES: To perform a list agreed by Argentinean experts and adapted to the local context containing potentially inappropriate (PI) medications in old people (OP) usingthe Delphi consensus technique optimized for this subject. METHODS: A preliminary list of potentially inappropriate medications (PIM) was drawn up based on foreign PIM lists and a selective search in the scientific literature. The iterative Delphi process was used to submit the active pharmaceutical ingredients (APIs) of the preliminary PIM list to the panel of Argentinean experts...
April 18, 2018: Value in Health Regional Issues
https://www.readbyqxmd.com/read/29678401/geographical-distribution-climate-adaptation-and-vector-competence-of-the-eurasian-hard-tick-haemaphysalis-concinna
#8
Franz Rubel, Katharina Brugger, Melanie Walter, Janna R Vogelgesang, Yuliya M Didyk, Su Fu, Olaf Kahl
The ixodid tick Haemaphysalis concinna Koch, 1844 is a proven vector of tick-borne encephalitis (TBE) virus and Francisella tularensis, the causative agent of tularaemia. In the present study, up-to-date maps depicting the geographical distribution and climate adaptation of H. concinna are presented. A dataset was compiled, resulting in 656 georeferenced locations in Eurasia. The distribution of H. concinna ranges from the Spanish Atlantic coast to Kamchatka, Russia, within the belt of 28-64° N latitude...
April 10, 2018: Ticks and Tick-borne Diseases
https://www.readbyqxmd.com/read/29677184/elasticity-based-boosting-of-neuroepithelial-nucleokinesis-via-indirect-energy-transfer-from-mother-to-daughter
#9
Tomoyasu Shinoda, Arata Nagasaka, Yasuhiro Inoue, Ryo Higuchi, Yoshiaki Minami, Kagayaki Kato, Makoto Suzuki, Takefumi Kondo, Takumi Kawaue, Kanako Saito, Naoto Ueno, Yugo Fukazawa, Masaharu Nagayama, Takashi Miura, Taiji Adachi, Takaki Miyata
Neural progenitor cells (NPCs), which are apicobasally elongated and densely packed in the developing brain, systematically move their nuclei/somata in a cell cycle-dependent manner, called interkinetic nuclear migration (IKNM): apical during G2 and basal during G1. Although intracellular molecular mechanisms of individual IKNM have been explored, how heterogeneous IKNMs are collectively coordinated is unknown. Our quantitative cell-biological and in silico analyses revealed that tissue elasticity mechanically assists an initial step of basalward IKNM...
April 20, 2018: PLoS Biology
https://www.readbyqxmd.com/read/29676806/obstacles-to-comprehensive-dental-care-in-patients-with-sustained-limitations-of-their-decision-making-abilities-findings-from-a-delphi-study
#10
Alessandra Blaizot, Céline Catteau, Caroline Delfosse, Olivier Hamel, Thomas Trentesaux
The objective of this study was to explore the therapeutic limitations experienced by a panel of special-care dentists in France when treating patients with sustained limitations of their decision-making abilities. We used a Delphi technique conducted in three rounds from 01 June 2014 to 30 September 2015. A first questionnaire comprising open-ended questions was addressed to 72 panellists. A content analysis of the returned questionnaires served to draft a second questionnaire comprising closed-ended questions; this was sent to the 28 panellists who responded in the first round...
April 20, 2018: European Journal of Oral Sciences
https://www.readbyqxmd.com/read/29674310/the-interactive-child-distress-screener-development-and-preliminary-feasibility-testing
#11
Sonja March, Jamin Day, Kirsty Zieschank, Michael Ireland
BACKGROUND: Early identification of child emotional and behavioral concerns is essential for the prevention of mental health problems; however, few suitable child-reported screening measures are available. Digital tools offer an exciting opportunity for obtaining clinical information from the child's perspective. OBJECTIVE: The aim of this study was to describe the initial development and pilot testing of the Interactive Child Distress Screener (ICDS). The ICDS is a Web-based screening instrument for the early identification of emotional and behavioral problems in children aged between 5 and 12 years...
April 19, 2018: JMIR MHealth and UHealth
https://www.readbyqxmd.com/read/29673310/atmad-robust-image-analysis-for-automatic-tissue-microarray-de-arraying
#12
Hoai Nam Nguyen, Vincent Paveau, Cyril Cauchois, Charles Kervrann
BACKGROUND: Over the last two decades, an innovative technology called Tissue Microarray (TMA), which combines multi-tissue and DNA microarray concepts, has been widely used in the field of histology. It consists of a collection of several (up to 1000 or more) tissue samples that are assembled onto a single support - typically a glass slide - according to a design grid (array) layout, in order to allow multiplex analysis by treating numerous samples under identical and standardized conditions...
April 19, 2018: BMC Bioinformatics
https://www.readbyqxmd.com/read/29673249/tracing-the-fate-of-atmospheric-nitrate-in-a-subalpine-watershed-using-%C3%AE-17-o
#13
Ilann Bourgeois, Joël Savarino, Nicolas Caillon, Helene Angot, Albane Barbero, Franck Delbart, Didier Voisin, Jean-Christophe Clement
Nitrogen is an essential nutrient for life on Earth, but in excess, it can lead to environmental issues (e.g., N saturation, loss of biodiversity, acidification of lakes, etc.). Understanding the nitrogen budget (i.e., inputs and outputs) is essential to evaluate the prospective decay of the ecosystem services (e.g., freshwater quality, erosion control, loss of high patrimonial-value plant species, etc.) that subalpine headwater catchments provide, especially as these ecosystems experience high atmospheric nitrogen deposition...
April 19, 2018: Environmental Science & Technology
https://www.readbyqxmd.com/read/29671379/enhanced-degradation-of-perfluorooctanoic-acid-by-a-genome-shuffling-modified-pseudomonas-parafulva-yab-1
#14
Langbo Yi, Qingzhong Peng, Deming Liu, Lulu Zhou, Chongjian Tang, Yaoyu Zhou, Liyuan Chai
Perfluorooctanoic acid (PFOA) as an emerging persistent organic pollutant is hard to be degraded by conventional methods because of its stable physical and chemical properties. Microbial transformation is an attractive remediation approach to prevent and clean up PFOA contamination. To date, several strains of wild microbes have been reported to have limited capacity to degrade PFOA, Selection of superior strains degrading PFOA become urgently necessary. Here, we report the application of genome shuffling to improve the PFOA-degrading bacterium Pseudomonas Parafulva YAB-1...
April 19, 2018: Environmental Technology
https://www.readbyqxmd.com/read/29666967/health-maintenance-in-inflammatory-bowel-disease
#15
REVIEW
Fazia A Mir, Sunanda V Kane
PURPOSE OF REVIEW: Patients with inflammatory bowel disease (IBD) are not receiving preventative care services at the same rate as the general population. IBD patients are at increased risk for infections, osteoporosis, and certain malignancies secondary to their disease and as they are on immunosuppressive therapy. They are a younger population and often times consider their gastroenterologist as their primary care physician. In this review, we discuss up-to-date evidence pertaining to vaccine-preventable illnesses in the immunosuppressed IBD patient, screening for bone health, cervical cancer, skin malignancies, psychological wellbeing, and smoking cessation...
April 17, 2018: Current Gastroenterology Reports
https://www.readbyqxmd.com/read/29663363/cervical-cancer-risk-in-hpv-positive-women-after-a-negative-fam19a4-mir124-2-methylation-test-a-post-hoc-analysis-in-the-pobascam-trial-with-14-year-follow-up
#16
Lise M A De Strooper, Johannes Berkhof, Renske D M Steenbergen, Birgit I Lissenberg-Witte, Peter J F Snijders, Chris J L M Meijer, Daniëlle A M Heideman
DNA methylation analysis of cervical scrapes using FAM19A4 and mir124-2 genes has shown a good clinical performance in detecting cervical cancer and advanced CIN lesions in need of treatment in HPV-positive women. To date, longitudinal data on the cancer risk of methylation test-negative women are lacking. In this study, we assessed the longitudinal outcome of FAM19A4/mir124-2 methylation analysis in an HPV-positive screening cohort with 14 years of follow-up. Archived HPV-positive cervical scrapes of 1040 women (age 29-61 years), who were enrolled in the POBASCAM screening trial (ISRCTN20781131) were tested for FAM19A4/mir124-2 methylation...
April 16, 2018: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/29662911/unaccounted-workload-factor-game-day-pitch-counts-in-high-school-baseball-pitchers-an-observational-study
#17
Jason L Zaremski, Giorgio Zeppieri, Deborah L Jones, Brady L Tripp, Michelle Bruner, Heather K Vincent, MaryBeth Horodyski
Background: Throwing injuries are common in high school baseball. Known risk factors include excessive pitch counts, year-round pitching, and pitching with arm pain and fatigue. Despite the evidence, the prevalence of pitching injuries among high school players has not decreased. One possibility to explain this pattern is that players accumulate unaccounted pitch volume during warm-up and bullpen activity, but this has not yet been examined. Hypotheses: Our primary hypothesis was that approximately 30% to 40% of pitches thrown off a mound by high school pitchers during a game-day outing are unaccounted for in current data but will be revealed when bullpen sessions and warm-up pitches are included...
April 2018: Orthopaedic Journal of Sports Medicine
https://www.readbyqxmd.com/read/29662528/oncoplastic-surgery-for-the-conservative-treatment-of-breast-cancer-in-per%C3%A3%C2%BA-s-national-cancer-institute
#18
Gonzalo Javier Ziegler Rodriguez, Marcelo Diaz Chavez, Gabriela Guadalupe Calderon Valencia, Jose Manuel Cotrina Concha, Milko Raphael Garces Castre, Raul Mantilla
Background: Oncoplastic surgery for breast cancer (OPS) has been a surgical trend for the past 25 years. In 2012, OPS has been introduced as the standard treatment for a selected group of patients at the National Cancer Institute of Peru (INEN). The aim of this study is to describe our findings. Methods: This is a retrospective and descriptive study that identified demographics, tumour-pathologic features and includes patients solely treated since diagnosis until late follow-up at INEN...
2018: Ecancermedicalscience
https://www.readbyqxmd.com/read/29661635/assessment-of-community-level-effects-of-intermittent-preventive-treatment-for-malaria-in-schoolchildren-in-jinja-uganda-start-ipt-trial-a-cluster-randomised-trial
#19
Sarah G Staedke, Catherine Maiteki-Sebuguzi, Andrea M Rehman, Simon P Kigozi, Samuel Gonahasa, Jaffer Okiring, Steve W Lindsay, Moses R Kamya, Clare I R Chandler, Grant Dorsey, Chris Drakeley
BACKGROUND: Intermittent preventive treatment (IPT) is a well established malaria control intervention. Evidence that delivering IPT to schoolchildren could provide community-level benefits is limited. We did a cluster-randomised controlled trial to assess the effect of IPT of primary schoolchildren with dihydroartemisinin-piperaquine (DP) on indicators of malaria transmission in the community, in Jinja, Uganda. METHODS: We included 84 clusters, each comprising one primary school and the 100 closest available households...
April 13, 2018: Lancet Global Health
https://www.readbyqxmd.com/read/29660830/cytologic-diagnosis-of-primary-peritoneal-high-grade-serous-carcinoma-in-a-man
#20
Brandon Umphress, John Philip, Yaxia Zhang, Xiaoqi Lin
Primary peritoneal serous carcinoma (PPSC) is a rare neoplasm histologically indistinguishable from ovarian serous carcinoma primarily occurring in the female population. To date, extremely rare cases of PPSC have been reported in men; however, diagnosis by cytology has yet to be described. Here we present the clinical, radiographic, cytomorphologic, histologic and immunohistochemical (IHC) findings of a high-grade (HG) PPSC in a 70-year-old man with a history of prostatic adenocarcinoma. Core needle biopsy (CNB) touch preparation smears showed pleomorphic, round, columnar and polygonal epithelioid cells present singly or arranged in loosely cohesive three-dimensional clusters...
April 16, 2018: Cytopathology: Official Journal of the British Society for Clinical Cytology
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