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https://www.readbyqxmd.com/read/29240304/weight-status-diet-quality-perceived-stress-and-functional-health-of-caregivers-of-children-with-autism-spectrum-disorder
#1
Xiaoyin Sara Li, Jennifer A Pinto-Martin, Aleda Thompson, Jesse Chittams, Tanja V E Kral
PURPOSE: Caring for children with autism spectrum disorder (ASD) can be highly demanding and can put significant strain on caregivers. To date, little is known about the extent to which caregivers of children with ASD experience increased levels of stress which may adversely affect health outcomes. The purpose of this secondary analysis was to compare caregivers of children with ASD and caregivers of typically developing children (TDC) in weight status, diet quality, perceived stress related to the parenting role, and functional health and well-being...
December 14, 2017: Journal for Specialists in Pediatric Nursing: JSPN
https://www.readbyqxmd.com/read/29239739/endophenotypes-a-conceptual-link-between-anorexia-nervosa-and-autism-spectrum-disorder
#2
Z C Zhou, D B McAdam, D R Donnelly
The paper, by translating the concept and the two models of endophenotype (EP), strengthens the hypothesis that there exists a linkage between anorexia nervosa (AN) and autism spectrum disorder (ASD). Specifically, the paper synthesizes empirical research that supported the idea that individuals with AN and individuals with ASD share similarities with respect to their neurocognitive EPs and temperament EPs. The paper then introduces an innovative structure to emphasize the subtle difference between neurocognitive EPs and temperament EPs in relation to AN and ASD...
November 24, 2017: Research in Developmental Disabilities
https://www.readbyqxmd.com/read/29238619/hippocampal-regulation-of-postsynaptic-density-homer1-by-associative-learning
#3
Nicholas E Clifton, Darren Cameron, Simon Trent, Lucy H Sykes, Kerrie L Thomas, Jeremy Hall
Genes involved in synaptic plasticity, particularly genes encoding postsynaptic density proteins, have been recurrently linked to psychiatric disorders including schizophrenia and autism. Postsynaptic density Homer1 proteins contribute to synaptic plasticity through the competing actions of short and long isoforms. The activity-induced expression of short Homer1 isoforms, Homer1a and Ania-3, is thought to be related to processes of learning and memory. However, the precise regulation of Homer1a and Ania-3 with different components of learning has not been investigated...
2017: Neural Plasticity
https://www.readbyqxmd.com/read/29238390/modulatory-effect-of-association-of-brain-stimulation-by-light-and-binaural-beats-in-specific-brain-waves
#4
Mauricio Rocha Calomeni, Vernon Furtado da Silva, Bruna Brandão Velasques, Olavo Guimarães Feijó, Juliana Marques Bittencourt, Alair Pedro Ribeiro de Souza E Silva
Introduction: One of the positive effects of brain stimulation is interhemispheric modulation as shown in some scientific studies. This study examined if a type of noninvasive stimulation using binaural beats with led-lights and sound would show different modulatory effects upon Alfa and SMR brain waves of elderlies and children with some disease types. Subjects: The sample included 75 individuals of both genders, being, randomly, divided in 6 groups. Groups were named elderly without dementia diagnosis (EWD), n=15, 76±8 years, elderly diagnosed with Parkinson's disease (EDP), n=15, 72±7 years, elderly diagnosed with Alzheimer's disease (EDA), n=15, 81±6 years...
2017: Clinical Practice and Epidemiology in Mental Health: CP & EMH
https://www.readbyqxmd.com/read/29235100/embryonic-exposure-to-valproic-acid-affects-the-histaminergic-system-and-the-social-behavior-of-adult-zebrafish-danio-rerio
#5
Diego Baronio, Henri A J Puttonen, Maria Sundvik, Svetlana Semenova, Essi Lehtonen, Pertti Panula
BACKGROUND AND PURPOSE: Histamine modulates several behaviors and physiological functions and its deficiency is associated with neuropsychiatric disorders. Gestational intake of valproic acid (VPA) is linked to Autism Spectrum Disorder (ASD), which is characterized by impaired sociability and stereotypies. VPA effects on the neurochemistry and functional morphology of the histaminergic system in ASD are unclear. Zebrafish are highly social and given the similarities between zebrafish and human neurotransmitter systems, we decided to use zebrafish to study VPA effects on histamine...
December 12, 2017: British Journal of Pharmacology
https://www.readbyqxmd.com/read/29234932/emotion-coregulation-processes-between-mothers-and-their-children-with-and-without-autism-spectrum-disorder-associations-with-children-s-maladaptive-behaviors
#6
Valentina Valentovich, Wendy A Goldberg, Dana Rose Garfin, Yuqing Guo
A dyadic microanalysis approach was used to examine emotion coregulation processes in mother-child interactions in relation to children's maladaptive behaviors. Seventy-two mother-child dyads (46 children with Autism Spectrum Disorder (ASD); 26 neurotypical children) were previously videotaped in a semi-structured play procedure at home and mothers reported on children's internalizing and externalizing behaviors. Mother-child interactions were reliably coded in 5-second intervals and analyzed using Space State Grid software...
December 12, 2017: Journal of Autism and Developmental Disorders
https://www.readbyqxmd.com/read/29233794/relevance-of-4-f4t-neuroprostane-and-10-f4t-neuroprostane-to-neurological-diseases
#7
Cinzia Signorini, Claudio De Felice, Thierry Durand, Jean-Marie Galano, Camille Oger, Silvia Leoncini, Lucia Ciccoli, Marisa Carone, Monica Ulivelli, Caterina Manna, Alessio Cortelazzo, Jetty Chung-Yung Lee, Joussef Hayek
F4-neuroprostanes (F4-NeuroPs) are non-enzymatic oxidized products derived from docosahexaenoic acid (DHA) and are suggested to be oxidative damage biomarkers of neurological diseases. However, 128 isomers can be formed from DHA oxidation and among them, 4(RS)-4-F4t-NeuroP (4-F4t-NeuroP) and 10(RS)-10-F4t-NeuroP (10-F4t-NeuroP) are the most studied. Here, we report the identification and the clinical relevance of 4-F4t-NeuroP and 10-F4t-NeuroP in plasma of four different neurological diseases, including multiple sclerosis (MS), autism spectrum disorders, (ASD) Rett syndrome (RTT), and Down syndrome (DS)...
December 9, 2017: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/29230396/altered-expression-of-endoplasmic-reticulum-stress-related-genes-in-the-middle-frontal-cortex-of-subjects-with-autism-spectrum-disorder
#8
Amanda Crider, Anthony O Ahmed, Anilkumar Pillai
The endoplasmic reticulum (ER) is an important organelle responsible for the folding and sorting of proteins. Disturbances in ER homeostasis can trigger a cellular response known as the unfolded protein response, leading to accumulation of unfolded or misfolded proteins in the ER lumen called ER stress. A number of recent studies suggest that mutations in autism spectrum disorder (ASD)-susceptible synaptic genes induce ER stress. However, it is not known whether ER stress-related genes are altered in the brain of ASD subjects...
November 2017: Molecular Neuropsychiatry
https://www.readbyqxmd.com/read/29230189/structural-covariance-of-sensory-networks-the-cerebellum-and-amygdala-in-autism-spectrum-disorder
#9
Garrett J Cardon, Susan Hepburn, Donald C Rojas
Sensory dysfunction is a core symptom of autism spectrum disorder (ASD), and abnormalities with sensory responsivity and processing can be extremely debilitating to ASD patients and their families. However, relatively little is known about the underlying neuroanatomical and neurophysiological factors that lead to sensory abnormalities in ASD. Investigation into these aspects of ASD could lead to significant advancements in our general knowledge about ASD, as well as provide targets for treatment and inform diagnostic procedures...
2017: Frontiers in Neurology
https://www.readbyqxmd.com/read/29229361/a-literature-review-on-maternal-fetal-and-reproductive-disorders-of-toxoplasma-gondii-infection
#10
REVIEW
Shirzad Fallahi, Ali Rostami, Malihe Nourollahpour Shiadeh, Hamed Behniafar, Shahrokh Paktinat
BACKGROUND: Toxoplasma gondii infection is one of the most prevalent infectious disease with worldwide distribution. Congenital toxoplasmosis is annually responsible for 1.20 million disability-adjusted life years around the world, but often it is overlooked many countries. METHODS: We performed an updated review to summarize the current researches on fetal, neonatal and maternal consequences of T. gondii infection and also adverse effects of toxoplasmosis on women reproductive organs...
December 8, 2017: Journal of Gynecology Obstetrics and Human Reproduction
https://www.readbyqxmd.com/read/29228834/quality-of-life-and-its-related-factors-for-adults-with-autism-spectrum-disorder
#11
Ling-Yi Lin, Pai-Chuan Huang
PURPOSE: Improved quality of life is an important outcome for adults with autism spectrum disorder. However, little research has examined factors associated with quality of life among adults with autism spectrum disorder. METHOD: This study comparing 66 adults with autism spectrum disorder (intelligence quotient > 70) aged 20-38 years with neuro-typical adults investigated their quality of life and related factors. All the participants were interviewed with questionnaires by a registered occupational therapist...
December 11, 2017: Disability and Rehabilitation
https://www.readbyqxmd.com/read/29226310/long-term-behavioural-outcomes-after-paediatric-convulsive-status-epilepticus-a-population-based-cohort-study
#12
Marina M Martinos, Suresh Pujar, Christopher Gillberg, Mario Cortina-Borja, Brian G R Neville, Michelle De Haan, Rod C Scott, Richard F M Chin
AIM: To describe behavioural and psychiatric outcomes of children within 10 years of convulsive status epilepticus (CSE). METHOD: Children originally identified by the population-based North London Convulsive Status Epilepticus in Childhood Surveillance Study were followed-up between July 2009 and February 2013. They were grouped into epilepsy- and non-epilepsy-related CSE, and compared with population norms and healthy controls using the Strengths and Difficulties Questionnaire; the Autism Spectrum Screening Questionnaire; and the Swanson, Nolan, and Pelham questionnaire...
December 10, 2017: Developmental Medicine and Child Neurology
https://www.readbyqxmd.com/read/29224969/aberrant-development-of-the-asymmetry-between-hemispheric-brain-white-matter-networks-in-autism-spectrum-disorder
#13
Long Wei, Suyu Zhong, Shengdong Nie, Gaolang Gong
Atypical brain asymmetry/lateralization has long been hypothesized for autism spectrum disorder (ASD), and this model has been repeatedly supported by various neuroimaging studies. Recently, hemispheric network topologies have been found to be asymmetric, thereby providing a new avenue for investigating brain asymmetries under various conditions. To date, however, how network topological asymmetries are altered in ASD remains largely unexplored. To clarify this, the present study included ASD individuals from the newly released Autism Brain Imaging Data Exchange II database (58 right-handed male ASD individuals aged 5 to 26 years and 70 age- and IQ-matched typically developing (TD) individuals)...
December 7, 2017: European Neuropsychopharmacology: the Journal of the European College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/29224188/an-evaluation-of-a-social-skills-intervention-for-adults-with-autism-spectrum-disorder-and-intellectual-disabilities-preparing-for-employment-in-ireland-a-pilot-study
#14
Edith Walsh, Jennifer Holloway, Helena Lydon
Individuals with autism spectrum disorder (ASD) are faced with significant barriers relating to employment opportunities and workplace participation. This study evaluated the effectiveness of the Walker social skills curriculum: the ACCESS program and video modeling to increase social communication skills necessary for workplace inclusion. Participants attended two sessions (i.e., 3 h) per week across a period of 20 weeks. A multiple-probe design was used to demonstrate social skills outcomes across three broad curricular areas (i...
December 9, 2017: Journal of Autism and Developmental Disorders
https://www.readbyqxmd.com/read/29224173/testing-the-specificity-of-executive-functioning-impairments-in-adolescents-with-adhd-odd-cd-and-asd
#15
Virginia Carter Leno, Susie Chandler, Pippa White, Andrew Pickles, Gillian Baird, Chris Hobson, Anna B Smith, Tony Charman, Katya Rubia, Emily Simonoff
Current diagnostic systems conceptualise attention deficit hyperactivity disorder (ADHD), oppositional defiant/conduct disorder (ODD/CD) and autism spectrum disorder (ASD) as separate diagnoses. However, all three demonstrate executive functioning (EF) impairments. Whether these impairments are trans-diagnostic or disorder-specific remains relatively unexplored. Four groups of 10-16 year-olds [typically developing (TD; N = 43), individuals clinically diagnosed with ADHD (N = 21), ODD/CD (N = 26) and ASD (N = 41)] completed Go/NoGo and Switch tasks...
December 9, 2017: European Child & Adolescent Psychiatry
https://www.readbyqxmd.com/read/29223496/multi-modal-imaging-investigation-of-anterior-cingulate-cortex-cytoarchitecture-in-neurodevelopment
#16
Natalie J Forde, Jilly Naaijen, David J Lythgoe, Sophie E A Akkermans, Thaïra J C Openneer, Andrea Dietrich, Marcel P Zwiers, Pieter J Hoekstra, Jan K Buitelaar
Multi-modal imaging may improve our understanding of the relationship between cortical morphology and cytoarchitecture. To this end we integrated the analyses of several magnetic resonance imaging (MRI) and spectroscopy (MRS) metrics within the anterior cingulate cortex (ACC). Considering the ACCs role in neurodevelopmental disorders, we also investigated the association between neuropsychiatric symptoms and the various metrics. T1 and diffusion-weighted MRI and 1H-MRS (ACC voxel) data along with phenotypic information were acquired from children (8-12 years) with various neurodevelopmental disorders (n=95) and healthy controls (n=50)...
December 6, 2017: European Neuropsychopharmacology: the Journal of the European College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/29222572/word-processing-in-children-with-autism-spectrum-disorders-evidence-from-event-related-potentials
#17
Micheal Sandbank, Paul Yoder, Alexandra P Key
Purpose: This investigation was conducted to determine whether young children with autism spectrum disorders exhibited a canonical neural response to word stimuli and whether putative event-related potential (ERP) measures of word processing were correlated with a concurrent measure of receptive language. Additional exploratory analyses were used to examine whether the magnitude of the association between ERP measures of word processing and receptive language varied as a function of the number of word stimuli the participants reportedly understood...
December 8, 2017: Journal of Speech, Language, and Hearing Research: JSLHR
https://www.readbyqxmd.com/read/29219245/behavior-profiles-of-children-with-autism-spectrum-disorder-in-kindergarten-comparison-with-other-developmental-disabilities-and-typically-developing-children
#18
Magdalena Janus, Emma Mauti, Matt Horner, Eric Duku, Ayesha Siddiqua, Scott Davies
Monitoring behavior patterns that may be specific to autism spectrum disorder (ASD) at a population level has the potential to improve the allocation of intervention strategies and reduction of the burden of the disease. In Ontario, Canada, developmental data are regularly collected for all kindergarten children with the Early Development Instrument (EDI), a teacher-completed questionnaire that provides information on children's status in five domains: physical, social, emotional, language/cognitive, and communication/general knowledge...
December 8, 2017: Autism Research: Official Journal of the International Society for Autism Research
https://www.readbyqxmd.com/read/29218394/modulation-of-sphingosine-1-phosphate-s1p-attenuates-spatial-learning-and-memory-impairments-in-the-valproic-acid-rat-model-of-autism
#19
Hongmei Wu, Quanzhi Zhang, Jingquan Gao, Caihong Sun, Jia Wang, Wei Xia, Yonggang Cao, Yanqiu Hao, Lijie Wu
RATIONALE: Autism spectrum disorders (ASD) are a set of pervasive neurodevelopmental disorders that manifest in early childhood, and it is growing up to be a major cause of disability in children. However, the etiology and treatment of ASD are not well understood. In our previous study, we found that serum levels of sphingosine 1-phosphate (S1P) were increased significantly in children with autism, indicating that S1P levels may be involved in ASD. OBJECTIVE: The objective of this study was to identify a link between increased levels of S1P and neurobehavioral changes in autism...
December 7, 2017: Psychopharmacology
https://www.readbyqxmd.com/read/29218006/reduced-levels-of-the-synaptic-functional-regulator-fmrp-in-dentate-gyrus-of-the-aging-sprague-dawley-rat
#20
Roman Smidak, Fernando J Sialana, Martina Kristofova, Tamara Stojanovic, Dragana Rajcic, Jovana Malikovic, Daniel D Feyissa, Volker Korz, Harald Hoeger, Judit Wackerlig, Diana Mechtcheriakova, Gert Lubec
Fragile X mental retardation protein (FMRP) encoded by Fragile X mental retardation 1 (FMR1) gene is a RNA-binding regulator of mRNA translation, transport and stability with multiple targets responsible for proper synaptic function. Epigenetic silencing of FMR1 gene expression leads to the development of Fragile X syndrome (FXS) that is characterized by intellectual disability and other behavioral problems including autism. In the rat FXS model, the lack of FMRP caused a deficit in hippocampal-dependent memory...
2017: Frontiers in Aging Neuroscience
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