keyword
MENU ▼
Read by QxMD icon Read
search

Autism related to

keyword
https://www.readbyqxmd.com/read/28088648/the-influence-of-5-httlpr-transporter-genotype-on-amygdala-subgenual-anterior-cingulate-cortex-connectivity-in-autism-spectrum-disorder
#1
Francisco Velasquez, Jillian Lee Wiggins, Whitney I Mattson, Donna M Martin, Catherine Lord, Christopher S Monk
Social deficits in autism spectrum disorder (ASD) are linked to amygdala functioning and functional connection between the amygdala and subgenual anterior cingulate cortex (sACC) is involved in the modulation of amygdala activity. Impairments in behavioral symptoms and amygdala activation and connectivity with the sACC seem to vary by serotonin transporter-linked polymorphic region (5-HTTLPR) variant genotype in diverse populations. The current preliminary investigation examines whether amygdala-sACC connectivity differs by 5-HTTLPR genotype and relates to social functioning in ASD...
December 23, 2016: Developmental Cognitive Neuroscience
https://www.readbyqxmd.com/read/28078576/feeding-problems-and-nutrient-intake-in-children-with-and-without-autism-a-comparative-study
#2
Prahbhjot Malhi, Lolam Venkatesh, Bhavneet Bharti, Pratibha Singhi
OBJECTIVE: To compare parent reported feeding difficulties and nutritional adequacy of children with Autism Spectrum Disorders (ASD) to an age and socio-economically matched group of typically developing children. METHODS: The scores on Children's Eating Behavior Inventory (CEBI), three-day food records, anthropometric measures and adequacy of micro- and macro- nutrients were compared for 63 children diagnosed with ASD and 50 typically developing children enrolled from the department of pediatrics of a tertiary care teaching hospital from North India...
January 12, 2017: Indian Journal of Pediatrics
https://www.readbyqxmd.com/read/28078312/biallelic-scn10a-mutations-in-neuromuscular-disease-and-epileptic-encephalopathy
#3
Marios Kambouris, Julien Thevenon, Ariane Soldatos, Allison Cox, Joshi Stephen, Tawfeg Ben-Omran, Yasser Al-Sarraj, Hala Boulos, William Bone, James C Mullikin, Alice Masurel-Paulet, Judith St-Onge, Yannis Dufford, Corrine Chantegret, Christel Thauvin-Robinet, Jamil Al-Alami, Laurence Faivre, Jean Baptiste Riviere, William A Gahl, Alexander G Bassuk, May Christine V Malicdan, Hatem El-Shanti
OBJECTIVES: Two consanguineous families, one of Sudanese ethnicity presenting progressive neuromuscular disease, severe cognitive impairment, muscle weakness, upper motor neuron lesion, anhydrosis, facial dysmorphism, and recurrent seizures and the other of Egyptian ethnicity presenting with neonatal hypotonia, bradycardia, and recurrent seizures, were evaluated for the causative gene mutation. METHODS AND RESULTS: Homozygosity mapping and whole exome sequencing (WES) identified damaging homozygous variants in SCN10A, namely c...
January 2017: Annals of Clinical and Translational Neurology
https://www.readbyqxmd.com/read/28077936/redox-proteomic-identification-of-carbonylated-proteins-in-autism-plasma-insight-into-oxidative-stress-and-its-related-biomarkers-in-autism
#4
Chengyun Feng, Youjiao Chen, Jintao Pan, Aochu Yang, Li Niu, Jie Min, Xianling Meng, Liping Liao, Kaoyuan Zhang, Liming Shen
BACKGROUND: Autism is a severe childhood neurological disorder with poorly understood etiology and pathology. Currently, there is no authentic laboratory test to confirm the diagnosis of autism. Oxidative damage may play a central role in the pathogenesis of autism. Present study is an effort to search for possible biomarkers of autism and further clarify the molecular changes associated with oxidative stress that occurs in the plasma of autistic children. METHODS: We performed redox proteomics analysis to compare carbonylated proteins in the plasma of autistic subjects and healthy controls...
2017: Clinical Proteomics
https://www.readbyqxmd.com/read/28077292/general-and-specific-factors-in-the-processing-of-faces
#5
Roeland J Verhallen, Jenny M Bosten, Patrick T Goodbourn, Adam J Lawrance-Owen, Gary Bargary, J D Mollon
The ability to recognize faces varies considerably between individuals, but does performance co-vary for tests of different aspects of face processing? For 397 participants (of whom the majority were university students) we obtained scores on the Mooney Face Test, Glasgow Face Matching Test (GFMT), Cambridge Face Memory Test (CFMT) and Composite Face Test. Overall performance was significantly correlated for each pair of tests, and we suggest the term f for the factor underlying this pattern of positive correlations...
January 7, 2017: Vision Research
https://www.readbyqxmd.com/read/28074329/dietary-adequacy-of-egyptian-children-with-autism-spectrum-disorder-compared-to-healthy-developing-children
#6
Nagwa A Meguid, Mona Anwar, Geir Bjørklund, Adel Hashish, Salvatore Chirumbolo, Maha Hemimi, Eman Sultan
Although the etiology and pathology of autism spectrum disorder (ASD) is still poorly understood, a number of environmental, anthropological, neurobiological and genetic factors have been related to the pathophysiology of ASD, even the impact of oxidative stress response related to the environment and nutrition intake. Usual recommended dietary habits are based on the combination of behavioral and dietary or nutraceutical interventions together with pharmacotherapy. Investigations about a reliable relationship between diet and ASD are still lacking...
January 10, 2017: Metabolic Brain Disease
https://www.readbyqxmd.com/read/28072468/a-multi-dimensional-functional-principal-components-analysis-of-eeg-data
#7
Kyle Hasenstab, Aaron Scheffler, Donatello Telesca, Catherine A Sugar, Shafali Jeste, Charlotte DiStefano, Damla Şentürk
The electroencephalography (EEG) data created in event-related potential (ERP) experiments have a complex high-dimensional structure. Each stimulus presentation, or trial, generates an ERP waveform which is an instance of functional data. The experiments are made up of sequences of multiple trials, resulting in longitudinal functional data and moreover, responses are recorded at multiple electrodes on the scalp, adding an electrode dimension. Traditional EEG analyses involve multiple simplifications of this structure to increase the signal-to-noise ratio, effectively collapsing the functional and longitudinal components by identifying key features of the ERPs and averaging them across trials...
January 10, 2017: Biometrics
https://www.readbyqxmd.com/read/28071825/systematic-review-of-severity-scales-and-screening-instruments-for-tics-critique-and-recommendations
#8
Davide Martino, Tamara M Pringsheim, Andrea E Cavanna, Carlo Colosimo, Andreas Hartmann, James F Leckman, Sheng Luo, Alexander Munchau, Christopher G Goetz, Glenn T Stebbins, Pablo Martinez-Martin
BACKGROUND: Several clinician, informant, and self-report instruments for tics and associated phenomena have been developed that differ in construct, comprehensiveness, and ease of administration. OBJECTIVE: A Movement Disorders Society subcommittee aimed to rate psychometric quality of severity and screening instruments for tics and related sensory phenomena. METHODS: Following the methodology adopted by previous Movement Disorders Society subcommittee papers, a review of severity and screening instruments for tics was completed, applying a classification as "recommended," "suggested," or "listed" to each instrument...
January 10, 2017: Movement Disorders: Official Journal of the Movement Disorder Society
https://www.readbyqxmd.com/read/28070788/developmental-markers-of-genetic-liability-to-autism-in-parents-a-longitudinal-multigenerational-study
#9
Molly Losh, Gary E Martin, Michelle Lee, Jessica Klusek, John Sideris, Sheila Barron, Thomas Wassink
Genetic liability to autism spectrum disorder (ASD) can be expressed in unaffected relatives through subclinical, genetically meaningful traits, or endophenotypes. This study aimed to identify developmental endophenotypes in parents of individuals with ASD by examining parents' childhood academic development over the school-age period. A cohort of 139 parents of individuals with ASD were studied, along with their children with ASD and 28 controls. Parents' childhood records in the domains of language, reading, and math were studied from grades K-12...
January 9, 2017: Journal of Autism and Developmental Disorders
https://www.readbyqxmd.com/read/28070783/brief-report-using-a-point-of-view-camera-to-measure-eye-gaze-in-young-children-with-autism-spectrum-disorder-during-naturalistic-social-interactions-a-pilot-study
#10
Sarah R Edmunds, Agata Rozga, Yin Li, Elizabeth A Karp, Lisa V Ibanez, James M Rehg, Wendy L Stone
Children with autism spectrum disorder (ASD) show reduced gaze to social partners. Eye contact during live interactions is often measured using stationary cameras that capture various views of the child, but determining a child's precise gaze target within another's face is nearly impossible. This study compared eye gaze coding derived from stationary cameras to coding derived from a "point-of-view" (PoV) camera on the social partner. Interobserver agreement for gaze targets was higher using PoV cameras relative to stationary cameras...
January 9, 2017: Journal of Autism and Developmental Disorders
https://www.readbyqxmd.com/read/28070762/being-on-your-own-or-feeling-lonely-loneliness-and-other-social-variables-in-youths-with-autism-spectrum-disorders
#11
Anne Deckers, Peter Muris, Jeffrey Roelofs
A cross-sectional study was conducted to examine loneliness and its correlates in children (7 to 11 years) and adolescents (12 to 18 years) with autism spectrum disorders (ASD, n = 73) and control groups of clinically referred (ADHD, n = 76) and non-clinical (n = 106) youths. Youths completed questionnaires on loneliness and desire for social interaction, while parents and teachers filled out scales on other aspects of children's social functioning. Results indicated that only at an adolescent age, the ASD group reported higher levels of loneliness than the control groups...
January 9, 2017: Child Psychiatry and Human Development
https://www.readbyqxmd.com/read/28070266/serum-and-cerebrospinal-fluid-immune-mediators-in-children-with-autistic-disorder-a-longitudinal-study
#12
Carlos A Pardo, Cristan A Farmer, Audrey Thurm, Fatma M Shebl, Jorjetta Ilieva, Simran Kalra, Susan Swedo
BACKGROUND: The causes of autism likely involve genetic and environmental factors that influence neurobiological changes and the neurological and behavioral features of the disorder. Immune factors and inflammation are hypothesized pathogenic influences, but have not been examined longitudinally. METHODS: In a cohort of 104 participants with autism, we performed an assessment of immune mediators such as cytokines, chemokines, or growth factors in serum and cerebrospinal fluid (n = 67) to determine potential influences of such mediators in autism...
2017: Molecular Autism
https://www.readbyqxmd.com/read/28068407/significant-association-of-urinary-toxic-metals-and-autism-related-symptoms-a-nonlinear-statistical-analysis-with-cross-validation
#13
James Adams, Daniel P Howsmon, Uwe Kruger, Elizabeth Geis, Eva Gehn, Valeria Fimbres, Elena Pollard, Jessica Mitchell, Julie Ingram, Robert Hellmers, David Quig, Juergen Hahn
INTRODUCTION: A number of previous studies examined a possible association of toxic metals and autism, and over half of those studies suggest that toxic metal levels are different in individuals with Autism Spectrum Disorders (ASD). Additionally, several studies found that those levels correlate with the severity of ASD. METHODS: In order to further investigate these points, this paper performs the most detailed statistical analysis to date of a data set in this field...
2017: PloS One
https://www.readbyqxmd.com/read/28065824/variable-white-matter-atrophy-and-intellectual-development-in-a-family-with-x-linked-creatine-transporter-deficiency-despite-genotypic-homogeneity
#14
Nicole Heussinger, Marc Saake, Angelika Mennecke, Helmuth-Günther Dörr, Regina Trollmann
BACKGROUND: The X-linked creatine transporter deficiency (CRTD) caused by an SLC6A8 mutation represents the second most common cause of X-linked intellectual disability. The clinical phenotype ranges from mild to severe intellectual disability, epilepsy, short stature, poor language skills, and autism spectrum disorders. The objective of this study was to investigate phenotypic variability in the context of genotype, cerebral creatine concentration, and volumetric analysis in a family with CRTD...
October 17, 2016: Pediatric Neurology
https://www.readbyqxmd.com/read/28063882/mice-lacking-grip1-2-show-increased-social-interactions-and-enhanced-phosphorylation-at-glua2-s880
#15
Mei Han, Rebeca Mejias, Shu-Ling Chiu, Rebecca Rose, Abby Adamczyk, Richard Huganir, Tao Wang
Glutamate receptor interacting proteins 1 and 2 (GRIP1/2) play an important role in regulating synaptic trafficking of AMPA receptor 2/3 (GluA2/3) and synaptic strength. Gain-of-function GRIP1 mutations are implicated in social behavioral deficits in autism. To study mechanisms of Grip1/2-mediated AMPA signaling in the regulation of social behaviors, we performed social behavioral testing on neuron-specific Grip1/2-double knockout (DKO) and wild type (WT) mice that are matched for age, sex, and strain background...
January 4, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/28062515/joint-attention-and-brain-functional-connectivity-in-infants-and-toddlers
#16
Adam T Eggebrecht, Jed T Elison, Eric Feczko, Alexandre Todorov, Jason J Wolff, Sridhar Kandala, Chloe M Adams, Abraham Z Snyder, John D Lewis, Annette M Estes, Lonnie Zwaigenbaum, Kelly N Botteron, Robert C McKinstry, John N Constantino, Alan Evans, Heather C Hazlett, Stephen Dager, Sarah J Paterson, Robert T Schultz, Martin A Styner, Guido Gerig, Samir Das, Penelope Kostopoulos, Bradley L Schlaggar, Steven E Petersen, Joseph Piven, John R Pruett
Initiating joint attention (IJA), the behavioral instigation of coordinated focus of 2 people on an object, emerges over the first 2 years of life and supports social-communicative functioning related to the healthy development of aspects of language, empathy, and theory of mind. Deficits in IJA provide strong early indicators for autism spectrum disorder, and therapies targeting joint attention have shown tremendous promise. However, the brain systems underlying IJA in early childhood are poorly understood, due in part to significant methodological challenges in imaging localized brain function that supports social behaviors during the first 2 years of life...
January 6, 2017: Cerebral Cortex
https://www.readbyqxmd.com/read/28060877/heightened-olfactory-sensitivity-in-young-females-with-recent-onset-anorexia-nervosa-and-recovered-individuals
#17
Mette Bentz, Johanne Guldberg, Signe Vangkilde, Tine Pedersen, Kerstin Jessica Plessen, Jens Richardt Moellegaard Jepsen
INTRODUCTION: Olfaction may be related to food restriction and weight loss. However, reports regarding olfactory function in individuals with anorexia nervosa (AN) have been inconclusive. OBJECTIVE: Characterize olfactory sensitivity and identification in female adolescents and young adults with first-episode AN and young females recovered from AN. METHODS: We used the Sniffin' Sticks Odor Threshold Test and Odor Identification Test to assess 43 participants with first-episode AN, 27 recovered participants, and 39 control participants...
2017: PloS One
https://www.readbyqxmd.com/read/28060873/assessment-of-anterior-cingulate-cortex-acc-and-left-cerebellar-metabolism-in-asperger-s-syndrome-with-proton-magnetic-resonance-spectroscopy-mrs
#18
Aya Goji, Hiromichi Ito, Kenji Mori, Masafumi Harada, Sonoka Hisaoka, Yoshihiro Toda, Tatsuo Mori, Yoko Abe, Masahito Miyazaki, Shoji Kagami
PURPOSE: Proton magnetic resonance spectroscopy (1H MRS) is a noninvasive neuroimaging method to quantify biochemical metabolites in vivo and it can serve as a powerful tool to monitor neurobiochemical profiles in the brain. Asperger's syndrome (AS) is a type of autism spectrum disorder, which is characterized by impaired social skills and restrictive, repetitive patterns of interest and activities, while intellectual levels and language skills are relatively preserved. Despite clinical aspects have been well-characterized, neurometabolic profiling in the brain of AS remains to be clear...
2017: PloS One
https://www.readbyqxmd.com/read/28058747/towards-a-neurochemical-profile-of-the-amygdala-using-short-te-1-h-magnetic-resonance-spectroscopy-at-3%C3%A2-t
#19
Florian Schubert, Simone Kühn, Jürgen Gallinat, Ralf Mekle, Bernd Ittermann
The amygdala plays a key role in emotional learning and in the processing of emotions. As disturbed amygdala function has been linked to several psychiatric conditions, a knowledge of its biochemistry, especially neurotransmitter levels, is highly desirable. The spin echo full intensity acquired localized (SPECIAL) sequence, together with a transmit/receive coil, was used to perform very short-TE magnetic resonance spectroscopy at 3 T to determine the neurochemical profile in a spectroscopic voxel containing the amygdala in 21 healthy adult subjects...
January 6, 2017: NMR in Biomedicine
https://www.readbyqxmd.com/read/28057930/atypical-developmental-trajectory-of-local-spontaneous-brain-activity-in-autism-spectrum-disorder
#20
Xiaonan Guo, Heng Chen, Zhiliang Long, Xujun Duan, Youxue Zhang, Huafu Chen
Autism spectrum disorder (ASD) is marked by atypical trajectory of brain maturation, yet the developmental abnormalities in brain function remain unclear. The current study examined the effect of age on amplitude of low-frequency fluctuations (ALFF) in ASD and typical controls (TC) using a cross-sectional design. We classified all the participants into three age cohorts: child (<11 years, 18ASD/20TC), adolescent (11-18 years, 28ASD/26TC) and adult (≥18 years, 18ASD/18TC). Two-way analysis of variance (ANOVA) was performed to ascertain main effects and interaction effects on whole brain ALFF maps...
January 6, 2017: Scientific Reports
keyword
keyword
87641
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"