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https://www.readbyqxmd.com/read/28922471/a-phenotype-combining-hidradenitis-suppurativa-with-dowling-degos-disease-caused-by-a-founder-mutation-in-psenen
#1
M Pavlovsky, O Sarig, M Eskin-Schwartz, N Malchin, R Bochner, J Mohamad, A Gat, A Peled, A Hafner, E Sprecher
Dowling-Degos disease, featuring reticulate pigmentation, and familial hidradenitis suppurativa share many clinical features including autosomal dominant inheritance, flexural location and follicular defects. The co-existence of the two disorders was recently found to result from mutations in PSENEN, encoding protein presenilin enhancer gamma-secretase subunit. Here we report 4 additional families of Jewish Ashkenazi origin who presented with clinical features characteristic of both disorders. All patients were found to carry the same, heterozygous mutation in PSENEN (c...
September 18, 2017: British Journal of Dermatology
https://www.readbyqxmd.com/read/28917381/uncovering-burden-disparity-a-comparative-analysis-of-the-impact-of-moderate-to-severe-psoriasis-and-hidradenitis-suppurativa
#2
Iltefat H Hamzavi, Murali Sundaram, Cynthia Nicholson, Marko Zivkovic, Angela Parks-Miller, Jianyi Lee, Jingbo Yi, Yihua Gu, Martin M Okun, Arijit Ganguli, Steve R Arikian
BACKGROUND: Psoriasis and hidradenitis suppurativa (HS) exhibit distinct clinical features, but no studies have directly compared the health-related quality of life (HRQoL) in patients with moderate-to-severe manifestations of these conditions. OBJECTIVE: To determine which disease is associated with more severe HRQoL impairment. METHODS: Weighted averages of each of the following baseline HRQoL measures were determined and compared between HS and psoriasis populations from 5 clinical trials: Visual Analog Scale (VAS) for pain, Total Work Productivity Impairment, Dermatology Life Quality Index; EuroQOL 5D VAS, and Short Form-36 Health Survey...
September 13, 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/28912816/review-of-current-immunologic-therapies-for-hidradenitis-suppurativa
#3
REVIEW
Victoria K Shanmugam, Nadia Meher Zaman, Sean McNish, Faye N Hant
Hidradenitis suppurativa (HS) is a chronic, recurrent, inflammatory disease of apocrine gland-bearing skin which affects approximately 1-4% of the population. The disease is more common in women and patients of African American descent and approximately one-third of patients report a family history. Obesity and smoking are known risk factors, but associations with other immune disorders, especially inflammatory bowel disease, are also recognized. The pathogenesis of HS is poorly understood and host innate or adaptive immune response, defective keratinocyte function, and the microbial environment in the hair follicle and apocrine gland have all been postulated to play a role in disease activity...
2017: International Journal of Rheumatology
https://www.readbyqxmd.com/read/28906288/ibd-live-series-case-8-treatment-options-for-refractory-esophageal-crohn-s-disease-and-hidradenitis-suppurativa
#4
Heba Iskandar, Julia B Greer, Alyssa M Krasinskas, Andrew T Tinsley, Walter A Koltun, Corey A Siegel, L Campbell Levy, Hans H Herfarth, Francis A Farraye, David G Binion, Joel R Rosh, David J Keljo, Kim L Isaacs, Miguel D Regueiro
No abstract text is available yet for this article.
October 2017: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/28904725/-hidradenitis-suppurativa-and-psoriasis-manifestation-of-a-hidden-disease
#5
Mouna Bouaddi, Badredine Hassam
No abstract text is available yet for this article.
2017: Pan African Medical Journal
https://www.readbyqxmd.com/read/28902952/successful-treatment-of-severe-recalcitrant-hidradenitis-suppurativa-with-the-interleukin-17a-antibody-secukinumab
#6
Anna Schuch, Tatjana Fischer, Alexander Boehner, Tilo Biedermann, Thomas Volz
No abstract text is available yet for this article.
September 13, 2017: Acta Dermato-venereologica
https://www.readbyqxmd.com/read/28898476/proceeding-report-of-the-symposium-on-hidradenitis-suppurativa-advances-shsa
#7
Ali Mehdizadeh, Afsaneh Alavi, Raed Alhusayen, Boris Bauer, Falk G Bechara, Marc Bourcier, Alain Brassard, Vahid Djamei, Jan Dutz, Ralph George, Mondana Ghias, Melinda Gooderham, Iltefat Hamzavi, Lauren K Hoffman, Angela Hou, Howard Hu, Alexa Boer Kimball, Mark Kirchhof, Darya Kryzskaya, Maria Del Carmen Liy Wong, Michelle A Lowes, Charles W Lynde, Chelsea McLellen, Errol Prens, Lisette Prens, Tetyana Rogalska, R Gary Sibbald, Mia Sisic, Marcus G Tan, Dennis D Wong
The Symposium on Hidradenitis Suppurativa Advances (SHSA) took place on 22-23 October 2016 at Women's College Hospital in Toronto, Canada. This symposium was a joint meeting of the Canadian Hidradenitis Suppurativa Foundation (CHSF), and the Hidradenitis Suppurativa Foundation (HSF Inc.) founded in USA. The purpose of this meeting was to gather well-known researchers from different disciplines to discuss most recent innovations, practical challenges and potential solutions to issues related to management and care of HS patients...
September 12, 2017: Experimental Dermatology
https://www.readbyqxmd.com/read/28898474/quality-of-life-measurement-in-acne-position-paper-of-the-european-academy-of-dermatology-and-venereology-eadv-task-forces-on-quality-of-life-and-patient-oriented-outcomes-qol-and-po-and-acne-rosacea-and-hidradenitis-suppurativa-arhs
#8
REVIEW
P V Chernyshov, C C Zouboulis, L Tomas-Aragones, G B Jemec, L Manolache, T Tzellos, F Sampogna, A W M Evers, C Dessinioti, S E Marron, V Bettoli, O D van Cranenburgh, A Svensson, A I Liakou, F Poot, J C Szepietowski, Salek, A Y Finlay
Acne causes profound negative psychological and social effects on the quality of life (QoL) of patients. The European Dermatology Forum S3-Guideline for the Treatment of Acne recommended adopting a QoL measure as an integral part of acne management. Because of constantly growing interest in health-related QoL assessment in acne and because of the high impact of acne on patients' lives, the European Academy of Dermatology and Venereology Task Force on QoL and Patient Oriented Outcomes and the Task Force on Acne, Rosacea and Hidradenitis Suppurativa have documented the QoL instruments that have been used in acne patients, with information on validation, purposes of their usage, description of common limitations and mistakes in their usage and overall recommendations...
September 12, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28887889/the-genetic-basis-for-most-patients-with-pustular-skin-disease-remains-elusive
#9
R Mössner, D Wilsmann-Theis, V Oji, P Gkogkolou, S Löhr, P Schulz, A Körber, J Christoph-Prinz, R Renner, K Schäkel, L Vogelsang, K-P Peters, S Philipp, K Reich, H Ständer, A Jacobi, A Weyergraf, K Kingo, S Kõks, S Gerdes, K Steinz, T Schill, K G Griewank, M Müller, S Frey, L Ebertsch, S Uebe, M Sticherling, H Sticht, U Hüffmeier
BACKGROUND: Rare variants in the genes IL36RN, CARD14 and AP1S3 have been identified to cause/ contribute to pustular skin diseases, primarily generalized pustular psoriasis (GPP). OBJECTIVES: To better understand the disease-relevance of these genes, we screened our cohorts of patients with pustular skin diseases (primarily GPP and palmoplantar pustular psoriasis [PPP]) for coding changes in these three genes. Carriers of single heterozygous IL36RN mutations were screened for a second mutation in IL36RN...
August 5, 2017: British Journal of Dermatology
https://www.readbyqxmd.com/read/28884797/sapho-syndrome-associated-with-hidradenitis-suppurativa-and-pyoderma-gangrenosum-successfully-treated-with-adalimumab-and-methotrexate-a-case-report-and-review-of-the-literature
#10
REVIEW
Dunja A Vekic, Jane Woods, Peter Lin, Geoffrey D Cains
SAPHO (synovitis, acne, pustulosis, hyperostosis, and osteitis) syndrome is a rare inflammatory condition describing the combination of skin, bone, and joint manifestations that has a heterogeneous presentation. We report a case of severe SAPHO syndrome in association with hidradenitis suppurativa and pyoderma gangrenosum in a 27-year-old male. The patient had an initial migratory arthritis affecting the knees, ankles, metacarpophalangeal joints, proximal interphalangeal joints, wrists, shoulder, and lower back, which progressed to a persistent arthritis and swelling at the sternum, shoulders, wrists, hands, feet, and lower back...
September 7, 2017: International Journal of Dermatology
https://www.readbyqxmd.com/read/28868004/a-disease-modifying-approach-for-advanced-hidradenitis-suppurativa-regimen-with-metformin-liraglutide-dapsone-and-finasteride-a-case-report
#11
Birgit N Khandalavala
Hidradenitis suppurativa (HS) is a challenging skin disease with limited therapeutic options. Obesity and metabolic syndrome are being increasingly implicated and associated with younger ages and greater metabolic severity. A 19-year-old female with an 8-year history of progressively debilitating cicatricial HS disease presented with obesity, profound anemia, leukocytosis, increased platelet count, hypoalbuminemia, and elevated liver enzymes. A combination of metformin, liraglutide, levonorgestrel-ethinyl estradiol, dapsone, and finasteride was initiated...
May 2017: Case Reports in Dermatology
https://www.readbyqxmd.com/read/28859733/hidradenitis-suppurativa-and-concomitant-down-syndrome-literature-review-of-other-associated-mucocutaneous-manifestations-in-adults
#12
Virendra N Sehgal, Naresh Sehgal, Ruchi Sehgal
This contribution describes hidradenitis suppurativa (HS) occurring in Down disease that presented with morphology conforming to an overlap of stages 1 and 2 of the Hurley staging system, namely the formation of solitary or multiple isolated abscesses without scarring or sinus tracts, recurrent abscesses, and single or multiple widely separated lesions with sinus tract formation, occupying apocrine sweat gland-bearing areas: the inner thighs, groin, and buttocks. The lesions were bilateral and symmetrical, of rare occurrence...
2017: Skinmed
https://www.readbyqxmd.com/read/28854317/canakinumab-for-severe-hidradenitis-suppurativa-preliminary-experience-in-2-cases
#13
Carine Houriet, S Morteza Seyed Jafari, Rahel Thomi, Christoph Schlapbach, Luca Borradori, Nikhil Yawalkar, Robert E Hunger
No abstract text is available yet for this article.
August 30, 2017: JAMA Dermatology
https://www.readbyqxmd.com/read/28852851/il-36-cytokines-are-increased-in-acne-and-hidradenitis-suppurativa
#14
Roberta Di Caprio, Anna Balato, Giuseppina Caiazzo, Serena Lembo, Annunziata Raimondo, Gabriella Fabbrocini, Giuseppe Monfrecola
Interleukin (IL)-36 cytokines are new members of the IL-1 family, which include pro-inflammatory factors, IL-36α, IL-36β and IL-36γ, and a natural receptor antagonist IL-36Ra. Over recent years, much has been learned on their important functions in the regulation of immune response and, especially, on their role in many inflammatory skin diseases. However, to date, no data have been reported on their possible involvement in acne and hidradenitis suppurativa (HS). Here, we have shown that IL-36α, IL-36β, and IL-36γ are increased in lesional skin of acne and HS, highlighting their possible pathogenetic contribution to these two skin conditions...
August 29, 2017: Archives of Dermatological Research
https://www.readbyqxmd.com/read/28852296/the-clinical-pattern-of-axillary-hidradenitis-suppurativa-among-saudi-arabians-mode-of-presentation-and-treatment-challenges
#15
Bader Hamza Shirah, Hamza Asaad Shirah
BACKGROUND: Hidradenitis suppurativa is a chronic follicular occlusive disease affecting the folliculopilosebaceous unit. The clinical course is variable, ranging from mild to severe cases. Definitive evidence-based guidelines for the management are lacking. In addition, the multifaceted clinical features and the unpredictable course of the disease make a uniform approach to treatment impractical. As a result, there are multiple therapeutic approaches. Therefore, in this study, we aim to analyze the results of management of axillary hidradenitis suppurativa among the local community in Saudi Arabia...
April 2017: Journal of Cutaneous and Aesthetic Surgery
https://www.readbyqxmd.com/read/28838562/disseminate-recurrent-folliculitis-as-the-presenting-picture-of-hidradenitis-suppurativa
#16
J Revuz
BACKGROUND: Hidradenitis suppurativa (HS) has a polymorphous clinical presentation. Herein we report two cases of HS revealed by disseminate recurrent folliculitis. PATIENTS AND METHODS CASE 1: A 31-year-old woman consulted for disseminate recurrent folliculitis on the trunk and proximal segments of the limbs that had been ongoing for several years. No other cutaneous lesions were seen, particularly in the classic area for HS lesions. Weight loss and treatment with azithromycin 500mg/day resulted in complete remission, but relapse occurred on dosage reduction...
August 21, 2017: Annales de Dermatologie et de Vénéréologie
https://www.readbyqxmd.com/read/28833590/moderate-to-severe-hidradenitis-suppurativa-patients-do-not-have-an-altered-bacterial-composition-in-peripheral-blood-compared-to-healthy-controls
#17
Hans Christian Ring, Jonathan Thorsen, Ditte Marie Saunte, Berit Lilje, Lene Bay, Peter Theut Riis, Niels Larsen, Lee O'Brien Andersen, Henrik Vedel Nielsen, Iben Marie Miller, Thomas Bjarnsholt, Kurt Fuursted, Gregor Borut Jemec
BACKGROUND: Hidradenitis Suppurativa (HS) is a chronic inflammatory skin disease defined by recurrent nodules, tunnels and scarring involving the intertriginous skin. HS patients often report an array of systemic symptoms such as fatigue and malaise. The etiology of these symptoms remains unclear. Previously, various bacteria have been associated with mature HS lesions and bacteremia has been reported in HS patients using traditional culturing methods. Thus, we hypothesized that a low-grade bacteremia contributes to the symptomatology in HS patients...
August 22, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28796920/recommendations-for-the-management-of-comorbidity-in-hidradenitis-suppurativa
#18
E Dauden, P Lazaro, M D Aguilar, A J Blasco, C Suarez, I Marin, R Queiro, J Bassas-Vila, A Martorell, J García-Campayo
BACKGROUND: The association between hidradenitis suppurativa (HS) and some diseases is becoming relevant in recent years. Providing appropriate management of HS from an early stage requires to include prompt diagnosis and treatment of concomitant diseases and to prevent any potential comorbidity. This approach should consider the adverse events of the drugs used to treat HS potentially related to the onset of a comorbidity. OBJECTIVE: To provide the dermatologist with an accurate, easily used tool that will inform the diagnosis of HS comorbidity, and to facilitate decision-making regarding the referral and treatment of patient with HS-associated comorbidity...
August 10, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28796910/factors-predicting-the-self-evaluated-health-of-hidradenitis-suppurativa-patients-recruited-from-an-outpatient-clinic
#19
R Kjaersgaard Andersen, P Theut Riis, G B E Jemec
OBJECTIVES: In recent years, Hidradenitis suppurativa has received increased attention, but still lack well-defined, robust patient reported outcome measures. Such measures are likely to be influenced by contextual factors. We therefore aim to describe the association of biological and other factors with HS patient's self-evaluated health as reflected by the EQ5D VAS score. METHODS: This cross-sectional study measured basic information, Dermatology Life Quality Index, Major Depression Inventory, and Euro-QoL-5D...
August 10, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28794864/hidradenitis-suppurativa-an-update-on-connecting-the-tracts
#20
REVIEW
Mallory K Smith, Cynthia L Nicholson, Angela Parks-Miller, Iltefat H Hamzavi
Hidradenitis suppurativa (HS) is a devastating disease involving abscesses, sinus tracts, and inflammation classically affecting the axilla, groin, and/or anogenital region. Although the disease pathogenesis is not fully understood, recent advances suggest that HS pathology runs much deeper than the cutaneous manifestations. It is now believed that HS is a systemic inflammatory disease that gives rise to the characteristic cutaneous manifestations. This disease is problematic for both patients and physicians to manage because of a variety of diagnostic and management difficulties...
2017: F1000Research
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