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https://www.readbyqxmd.com/read/28319284/advanced-squamous-cell-carcinoma-of-the-axillae-mimicking-hidradenitis-suppurativa
#1
Clio Dessinioti, Mikaella Plaka, Chrisa Zisimou, Eleftheria Christofidou, Christina Antoniou, Alexander J Stratigos
A 56 year-old man presented to our Hidradenitis Clinic with an exophytic, bovine-red, ulcerated plaque in the left axillae (figure 1). He reported that he was diagnosed with hidradenitis suppurativa when this lesion first appeared 8 years ago, as a single small, occasionally purulent, nodule, that had enlarged considerably over the past 7 months. He had previously received oral and topical antibiotics with no improvement. This article is protected by copyright. All rights reserved.
March 20, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28301691/interleukin-32-is-highly-expressed-in-lesions-of-hidradenitis-suppurativa
#2
R Thomi, D Yerly, N Yawalkar, D Simon, C Schlapbach, R E Hunger
BACKGROUND: Hidradenitis suppurativa (HS) is a chronic inflammatory skin disease. Its immunopathogenic mechanisms are still poorly understood. Previous studies could demonstrate that the pro-inflammatory cytokine Interleukin-32 (IL-32) is implicated in the pathogenesis of other inflammatory diseases. OBJECTIVES: The aim of our study was to investigate the tissue expression and systemic levels of IL-32 as well as its cellular sources in HS patients in comparison to healthy donors and to patients suffering from two other inflammatory skin diseases: psoriasis (PS) and atopic dermatitis (AD)...
March 16, 2017: British Journal of Dermatology
https://www.readbyqxmd.com/read/28300893/steatocystoma-multiplex-suppurativa-case-report-of-a-rare-condition
#3
Cândida Naira Lima E Lima Santana, Daniele do Nascimento Pereira, Alice Paixão Lisboa, Juliana Martins Leal, Daniel Lago Obadia, Roberto Souto da Silva
Steatocystoma multiplex is a rare genetic disorder characterized by the presence of hamartomatous malformations at the junction of the pilosebaceous duct. It consists of encapsulated cystic lesions in the dermis, with adjacent sebaceous gland. When associated with inflammation, resembling hidradenitis, it is called steatocystoma multiplex suppurativa, a condition rarely reported. This is the first case of steatocystoma multiplex suppurativa reported in the Brazilian literature. Female patient, 23 years old, with papular and nodular cystic lesions that started in the armpits and groin, later spreading to the trunk, lower limbs, anticubital fossa, face and scalp...
September 2016: Anais Brasileiros de Dermatologia
https://www.readbyqxmd.com/read/28300853/the-international-dermatology-outcome-measures-ideom-initiative-a-review-and-update
#4
Scott A Elman, Joseph F Merola, April W Armstrong, Kristina Callis Duffin, John Latella, Amit Garg, Alice B Gottlieb
<p>The International Dermatology Outcome Measures (IDEOM) group, comprising patients, physicians, health economists, industry partners, payers, and regulatory agencies, was established to develop unified and validated patient-centered outcome measures in dermatology in response to increasing demand to quantify effectiveness of treatments and performance outcomes among providers. IDEOM has chosen to start with psoriasis outcome measures, and then apply its methodology to other dermatologic diseases. In this paper, we review the background and progress to date of IDEOM, including an update of IDEOM activities as of our 2016 meeting in Washington DC, USA...
February 1, 2017: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/28300335/risk-factors-for-cardiovascular-disease-in-patients-with-hidradenitis-suppurativa
#5
Caroline Vinkel, Simon Francis Thomsen
We read with great interest the article by Pascual et al., in which subclinical atherosclerosis in patients with hidradenitis suppurativa (HS) was assessed using carotid ultrasound. They found a higher prevalence of subclinical atherosclerosis in HS patients (30.7%) compared with controls (16.1%) and the association was significant in patients 40 years and older. Furthermore, traditional cardiovascular (CV) risk factors like hypertension (41.9%), diabetes mellitus (22.6%), and metabolic syndrome (38.7%) along with elevated systemic inflammatory markers including high-sensitivity C-reactive protein (Hs-CRP) (61...
March 16, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28300331/assessment-of-subclinical-atherosclerosis-in-hidradenitis-suppurativa-reply-to-dr-vinkel-s-letter
#6
Iris González, José C Pascual, Diego Corona, Patricia Hispán, José M Ramos, José Sánchez-Paya, Gregor B Jemec
We read with great interest the letter by Vinkel et al., commenting on our published article "Assessment of subclinical atherosclerosis in hidradenitis suppurativa"(1) .We reported that patients with hidradenitis suppurativa may have a higher prevalence of subclinical atherosclerosis, especially in patients 40 years and older. These findings may not be attributable exclusively to traditional risk factors alone. Vinkel et al., assessed the presence of traditional cardiovascular risk factors in Danish patients with HS...
March 16, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28300328/prevalence-and-incidence-of-hidradenitis-suppurativa-an-exercise-on-indirect-estimation-from-psoriasis-data
#7
L Fania, F Ricci, F Sampogna, C Mazzanti, B Didona, G Pintori, D Abeni
while hidradenitis suppurativa (HS) is recently attracting much attention, uncertainty surrounds the actual extent of the occurrence of this disease. A comprehensive review of the epidemiology of HS(1) reported data ranging from <0.1%(2,3) to 8%(4) , allowing the Authors to conclude that the prevalence of HS may approach that of psoriasis(1) . Starting from this statement, we compared occurrence data of HS with those of psoriasis in a large clinical data set collected in a dermatological reference center, to provide a "ballpark" estimate of prevalence and incidence of HS in Italy...
March 16, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28293556/generalized-comedones-acne-and-hidradenitis-suppurativa-in-a-patient-with-an-fgfr2-missense-mutation
#8
Rebecca Higgins, Andrew Pink, Robert Hunger, Nikhil Yawalkar, Alexander A Navarini
Mutations in the fibroblast growth factor-receptor gene 2 (FGFR2) gene have been implicated in numerous diseases, including nevus comedonicus (NC) and naevoid acne that have somatic missense mutations in FGFR2 in the affected tissue. A patient presented in our department with unusual, innumerable large comedones throughout his back reminiscient of NC, as well as multifocal hidradenitis suppurativa and acne. Topical and systemic treatments were unsuccessful. Whole exome sequencing of blood-derived DNA detected a germline mutation in FGFR2 that was predicted to be damaging...
2017: Frontiers in Medicine
https://www.readbyqxmd.com/read/28289934/anoperineal-disease-in-hidradenitis-suppurativa-mr-imaging-distinction-from-perianal-crohn-s-disease
#9
Louise Monnier, Anthony Dohan, Nedjoua Amara, Anne-Marie Zagdanski, Moustapha Drame, Philippe Soyer, Christine Hoeffel
OBJECTIVE: To determine whether Hidradenitis suppurativa (HS)-related anoperineal disease can be distinguished from Crohn's disease (CD) using MRI. METHODS: Pelvic MRI of 23 HS and 46 CD patients with anoperineal disease between 2007 and 2014 were independently analysed by two radiologists. For diagnosis of HS, sensitivity, specificity and positive likelihood ratios (LRs) of inflammatory features and of their anatomical distribution were calculated and compared to those of CD...
March 13, 2017: European Radiology
https://www.readbyqxmd.com/read/28285782/incidence-of-hidradenitis-suppurativa-in-the-united-states-a-sex-and-age-adjusted-population-analysis
#10
Amit Garg, Jonathan Lavian, Gloria Lin, Andrew Strunk, Allireza Alloo
BACKGROUND: The true incidence of hidradenitis suppurativa (HS) is unknown. OBJECTIVE: To determine standardized incidence estimates for HS in the United States. METHODS: We used a retrospective cohort analysis, including incident HS cases identified using electronic health records data for a demographically heterogeneous population-based sample of >48 million unique patients across all 4 census regions. We calculated standardized 1- and 10-year cumulative incidences for the overall population and for sex-, age-, and race-specific groups...
March 9, 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/28278367/a-systematic-review-and-critical-evaluation-of-reported-pathogenic-sequence-variants-in-hidradenitis-suppurativa
#11
REVIEW
J W Frew, D A Vekic, J Woods, G D Cains
INTRODUCTION: Hidradenitis Suppurativa (HS) is a severe chronic inflammatory disorder characterised by recurrent painful deep seated nodules with a predilection to the apocrine bearing areas of skin. A minority of cases of HS are due to mutations in the gamma secretase complex. Contention exists surrounding the pathogenicity of sequence variants and their effects upon notch signalling. METHODS: This systematic review was registered with PROSPERO (CRD42016041425) and was conducted in line with the PRISMA statement...
March 9, 2017: British Journal of Dermatology
https://www.readbyqxmd.com/read/28274364/squamous-cell-carcinoma-arising-in-long-standing-hidradenitis-suppurativa-an-overlooked-facet-of-the-immunocompromised-district
#12
Gabriella Fabbrocini, Eleonora Ruocco, Valerio De Vita, Giuseppe Monfrecola
The list of comorbidities and complications associated with hidradenitis suppurativa is extensive. Among the complications of hidradenitis suppurativa, squamous cell carcinoma is considered the most severe. After a meticulous literature research starting from the 1950s, we were able to identify over 90 cases of patients with hidradenitis suppurativa developing squamous cell carcinoma. Most squamous cell carcinomas appear on the perineal or buttock areas. We believe that the development of squamous cell carcinoma in longstanding hidradenitis suppurativa is a typical condition of an immunocompromised district...
March 2017: Clinics in Dermatology
https://www.readbyqxmd.com/read/28274363/treatments-for-hidradenitis-suppurativa
#13
R Kjærsgaard Andersen, Gregor B E Jemec
Hidradenitis suppurativa (HS) is not easily treated. Although not uncommon, HS is often misdiagnosed outside specialized clinics and inappropriately treated as a simple boil or abscess. In recent years, guidelines have been developed on the basis of expert opinion and the available literature. A multifaceted approach is necessary as HS lesions include both inflammation (amenable to medical treatment) as well as fibrosis (amenable to surgery only). The recommended antiinflammatory therapies encompass both antimicrobials and regular anti-inflammatory drugs...
March 2017: Clinics in Dermatology
https://www.readbyqxmd.com/read/28274347/the-changing-faces-of-acne-rosacea-and-hidradenitis-suppurativa
#14
EDITORIAL
Andreas Katsambas, Clio Dessinioti
No abstract text is available yet for this article.
March 2017: Clinics in Dermatology
https://www.readbyqxmd.com/read/28263194/carbon-dioxide-laser-treatment-using-methylene-blue-assisted-sinus-tract-identification-in-hidradenitis-suppurativa
#15
Lennart Emtestam, Jan Lapins, Karin Sartorius
No abstract text is available yet for this article.
March 2, 2017: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
https://www.readbyqxmd.com/read/28261036/increased-serum-interleukin-6-levels-in-patients-with-hidradenitis-suppurativa
#16
Haoxiang Xu, Xuemin Xiao, Yanyan He, Xiaofeng Zhang, Chengrang Li, Qiuxia Mao, Xinfeng Wu, Baoxi Wang
No abstract text is available yet for this article.
February 2017: Postȩpy Dermatologii i Alergologii
https://www.readbyqxmd.com/read/28259215/higher-risk-of-care-for-hidradenitis-suppurativa-in-african-american-and-non-hispanic-patients-in-the-united-states
#17
Nneka S Udechukwu, Alan B Fleischer
Hidradenitis suppurativa (HS) is a chronic cutaneous inflammatory disease. Few reports have been published on the influence of race, ethnicity, and other patient demographic factors as determinants of care for HS. Data from the 2005 to 2011 National Ambulatory Medical Care Survey (NAMCS) and the National Hospital Ambulatory Medical Care Survey (NHAMCS) were analyzed for to assess factors that were predictive of outpatient visits for HS. Logistic regression controlling for demographic and other factors showed several disparities...
April 2017: Journal of the National Medical Association
https://www.readbyqxmd.com/read/28256959/squamous-cell-carcinoma-arising-in-chronic-hidradenitis-suppurativa-a-lethal-complication-to-be-avoided
#18
Le-Qi Zhang, Cheng Tan
No abstract text is available yet for this article.
March 2017: Acta Oncologica
https://www.readbyqxmd.com/read/28256718/lipocalin-2-is-expressed-by-activated-granulocytes-and-keratinocytes-in-affected-skin-and-reflects-disease-activity-in-acne-inversa-hidradenitis-suppurativa
#19
K Wolk, J Wenzel, A Tsaousi, E Witte-Händel, N Babel, C Zelenak, H-D Volk, W Sterry, S Schneider-Burrus, R Sabat
BACKGROUND: Acne inversa (AI)/Hidradenitis suppurativa is a chronic inflammatory disease characterized by painful axillary, inguinal, and perianal skin lesions with deep-seated nodules, abscesses, and fistulae. OBJECTIVES: This study aimed at the identification and characterization of key players in AI pathogenesis. METHODS: Epidemiologic and anamnestic data as well as blood and skin samples of AI patients were collected. Healthy participants and psoriasis patients served as controls...
March 3, 2017: British Journal of Dermatology
https://www.readbyqxmd.com/read/28244073/nice-approval-of-adalimumab-for-moderate-to-severe-hidradenitis-suppurativa-the-end-of-the-beginning-for-hidradenitis-suppurativa-therapeutics
#20
EDITORIAL
J R Ingram, T Burton
No abstract text is available yet for this article.
February 2017: British Journal of Dermatology
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