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Infectious modification

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https://www.readbyqxmd.com/read/28096124/nutritional-considerations-for-healthy-aging-and-reduction-in-age-related-chronic-disease
#1
REVIEW
Julie Shlisky, David E Bloom, Amy R Beaudreault, Katherine L Tucker, Heather H Keller, Yvonne Freund-Levi, Roger A Fielding, Feon W Cheng, Gordon L Jensen, Dayong Wu, Simin N Meydani
A projected doubling in the global population of people aged ≥60 y by the year 2050 has major health and economic implications, especially in developing regions. Burdens of unhealthy aging associated with chronic noncommunicable and other age-related diseases may be largely preventable with lifestyle modification, including diet. However, as adults age they become at risk of "nutritional frailty," which can compromise their ability to meet nutritional requirements at a time when specific nutrient needs may be high...
January 2017: Advances in Nutrition
https://www.readbyqxmd.com/read/28091706/microclimates-might-limit-indirect-spillover-of-the-bat-borne-zoonotic-hendra-virus
#2
Gerardo Martin, Rebecca J Webb, Carla Chen, Raina K Plowright, Lee F Skerratt
Infectious diseases are transmitted when susceptible hosts are exposed to pathogen particles that can replicate within them. Among factors that limit transmission, the environment is particularly important for indirectly transmitted parasites. To try and assess a pathogens' ability to be transmitted through the environment and mitigate risk, we need to quantify its decay where transmission occurs in space such as the microclimate harbouring the pathogen. Hendra virus, a Henipavirus from Australian Pteropid bats, spills-over to horses and humans, causing high mortality...
January 14, 2017: Microbial Ecology
https://www.readbyqxmd.com/read/28069866/trim-proteins-and-diseases
#3
REVIEW
Masashi Watanabe, Shigetsugu Hatakeyama
Ubiquitination is one of the posttranslational modifications that regulates a number of intracellular events including signal transduction, protein quality control, transcription, cell cycle, apoptosis and development. The ubiquitin system functions as a garbage machine to degrade target proteins and as a regulator for several signalling pathways. Biochemical reaction of ubiquitination requires several enzymes including E1, E2 and E3, and E3 ubiquitin ligases play roles as receptors for recognizing target proteins...
January 7, 2017: Journal of Biochemistry
https://www.readbyqxmd.com/read/28066604/shifted-focus-of-bronchoalveolar-lavage-in-patients-with-suspected-thoracic-malignancy-an-analysis-of-224-patients
#4
Xin Zhang, Yukun Kuang, Yuan Zhang, Kai He, Noah Lechtzin, Mingying Zeng, Rex C Yung, Canmao Xie
BACKGROUND: Bronchoscopies are extensively adopted for diagnosing and staging thoracic malignancies, but studies are missing as how to keep the process streamlined and more efficient. To evaluate current role of bronchoalveolar lavage (BAL) for cancer and possible infection diagnosis when practicing comprehensive bronchoscopy for patients suspected with thoracic malignancy, and provide foundation for possible practice modification. METHODS: We retrospectively analyzed a prospectively kept database of immunocompetent patients undergoing bronchoscopy for suspected non-hematologic malignancies...
November 2016: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/28057212/regulation-of-cellular-immune-responses-in-sepsis-by-histone-modifications
#5
W F Carson, S L Kunkel
Severe sepsis, septic shock, and related inflammatory syndromes are driven by the aberrant expression of proinflammatory mediators by immune cells. During the acute phase of sepsis, overexpression of chemokines and cytokines drives physiological stress leading to organ failure and mortality. Following recovery from sepsis, the immune system exhibits profound immunosuppression, evidenced by an inability to produce the same proinflammatory mediators that are required for normal responses to infectious microorganisms...
2017: Advances in Protein Chemistry and Structural Biology
https://www.readbyqxmd.com/read/28036306/infections-with-biological-therapy-strategies-for-risk-minimization-in-tropical-and-developing-countries
#6
Carlos E Pérez-Díaz, Erika Uribe-Pardo, Omar-Javier Calixto, Álvaro A Faccini-Martínez, Alfonso J Rodriguez-Morales
In recent decades, biological therapy has enabled disease activity control and improved quality of life in patients with autoimmune diseases. These therapies that are involved in immune response modifications and change multiple immunological pathways induce an incremental risk for certain infectious diseases. Though there have been recent advances in risk assessment for biological therapy, there is a lack of data and recommendations for assessing risks in populations with high prevalence of infectious diseases, such as those located in tropical areas and developing countries...
December 30, 2016: Journal of Infection in Developing Countries
https://www.readbyqxmd.com/read/28034743/discovery-of-host-targeted-covalent-inhibitors-of-dengue-virus
#7
Mélissanne de Wispelaere, Margot Carocci, Yanke Liang, Qingsong Liu, Eileen Sun, Michael L Vetter, Jinhua Wang, Nathanael S Gray, Priscilla L Yang
We report here on an approach targeting the host reactive cysteinome to identify inhibitors of host factors required for the infectious cycle of Flaviviruses and other viruses. We used cellular phenotypic screens to identify a series of covalent inhibitors, exemplified by QL-XII-47, that are active against dengue virus. We demonstrate that the compounds effectively block viral protein expression. This inhibition is associated with repression of downstream processes of the infectious cycle, and thus significantly contributes to the potent antiviral activity of these compounds...
December 26, 2016: Antiviral Research
https://www.readbyqxmd.com/read/28029542/vector-based-genetically-modified-vaccines-exploiting-jenner-s-legacy
#8
Bahar Ramezanpour, Ingrid Haan, Ab Osterhaus, Eric Claassen
The global vaccine market is diverse while facing a plethora of novel developments. Genetic modification (GM) techniques facilitate the design of 'smarter' vaccines. For many of the major infectious diseases of humans, like AIDS and malaria, but also for most human neoplastic disorders, still no vaccines are available. It may be speculated that novel GM technologies will significantly contribute to their development. While a promising number of studies is conducted on GM vaccines and GM vaccine technologies, the contribution of GM technology to newly introduced vaccines on the market is disappointingly limited...
October 28, 2016: Vaccine
https://www.readbyqxmd.com/read/28018695/from-benign-to-malign-in-a-case-of-cervical-adenopathy-in-a-17-year-old-adolescent-diagnostic-traps
#9
Simona Dumitra, Maria Trailescu, Amelia Burlea, Claudia Covaci, Ozana Balan, Adrian Pavel, Carmen Crișan
Distinguishing between benign and malign adenopathies remains a challenge and could represent a source of error in a diagnosis. We report a case of right laterocervical adenopathy in a 17-year-old teenager admitted to hospital with an episode of fever associated with dysphagia, congested pharynx, and pultaceous deposits. Initially the adenopathy was considered to be secondary to a coinfection with Streptococcus B-hemolytic and Epstein-Barr virus, as suggested by the positive bacteriological and serological tests...
2016: Case Reports in Pediatrics
https://www.readbyqxmd.com/read/28011975/dental-worm-disease
#10
Sergio Sabbatani, Sirio Fiorino
During human evolution, the period in which groups of humans stopped harvesting fruits and seeds growing wild and introduced the cultivation of cereals as well as the domestication of animals represents a very important event. This circumstance had a considerable impact on human pathocenosis, increasing the risk of infectious diseases of animal origin. The aim of this review was to summarise the archaeological and palaeo-pathological evidence in the literature concerning this topic. Starting from early prehistory (about 1...
1, 2016: Le Infezioni in Medicina
https://www.readbyqxmd.com/read/28009396/cruise-tap-versus-handshake-using-common-sense-to-reduce-hand-contamination-and-germ-transmission-on-cruise-ships
#11
Eilif Dahl
A firm handshake is a widely used greeting, but contaminated fingers and palms can also transfer bacteria and virus. Hand sanitation is important to prevent spreading of contagious diseases, but to wash hands properly takes too much time to ensure satisfactory compliance. Banning the handshake from health care settings has been proposed, but an alternative, less contagious form of greeting must be substituted. Cruise ships are particular vulnerable to infectious diseases that are transferred from person to person...
2016: International Maritime Health
https://www.readbyqxmd.com/read/27992675/readmissions-after-adult-congenital-heart-surgery-frequency-and-risk-factors
#12
Yuli Y Kim, Wei He, Thomas E MacGillivray, Oscar J Benavidez
OBJECTIVE: Despite their clinical importance, 30-day readmission after adult congenital heart surgery has been understudied. They sought to determine the frequency of unplanned readmissions after adult congenital heart surgery and to identify any potential associated risk factors. DESIGN: Retrospective cohort study using State Inpatient Databases for Washington, New York, Florida, and California from 2009 to 2011. SETTING: Federal and nonfederal acute care hospitals...
December 19, 2016: Congenital Heart Disease
https://www.readbyqxmd.com/read/27990151/genome-editing-technologies-for-enhancing-plant-disease-resistance
#13
REVIEW
Giuseppe Andolfo, Paolo Iovieno, Luigi Frusciante, Maria R Ercolano
One of the greatest challenges for agricultural science in the 21st century is to improve yield stability through the progressive development of superior cultivars. The increasing numbers of infectious plant diseases that are caused by plant-pathogens make it ever more necessary to develop new strategies for plant disease resistance breeding. Targeted genome engineering allows the introduction of precise modifications directly into a commercial variety, offering a viable alternative to traditional breeding methods...
2016: Frontiers in Plant Science
https://www.readbyqxmd.com/read/27974570/channel-inactivating-mutations-and-their-revertant-mutants-in-the-envelope-protein-of-the-infectious-bronchitis-virus
#14
Janet To, Wahyu Surya, To Sing Fung, Yan Li, Carmina Verdià-Bàguena, Maria Queralt-Martin, Vicente M Aguilella, Ding Xiang Liu, Jaume Torres
: It has been shown previously in the severe acute respiratory syndrome coronavirus (SARS-CoV) that two point mutations, N15A and V25F, in the transmembrane domain (TMD) of the envelope (E) protein abolished channel activity and led to in vivo attenuation. Pathogenicity was recovered in mutants that also regained E protein channel activity. In particular, V25F was rapidly compensated by changes at multiple V25F-facing TMD residues located on a neighboring monomer, consistent with a recovery of oligomerization...
December 14, 2016: Journal of Virology
https://www.readbyqxmd.com/read/27974057/validation-of-icd-9-cm-diagnosis-codes-for-surgical-site-infection-and-noninfectious-wound-complications-after-mastectomy
#15
Margaret A Olsen, Kelly E Ball, Katelin B Nickel, Anna E Wallace, Victoria J Fraser
BACKGROUND Few studies have validated ICD-9-CM diagnosis codes for surgical site infection (SSI), and none have validated coding for noninfectious wound complications after mastectomy. OBJECTIVES To determine the accuracy of International Classification of Diseases, Ninth Revision, Clinical Modification (ICD-9-CM) diagnosis codes in health insurer claims data to identify SSI and noninfectious wound complications, including hematoma, seroma, fat and tissue necrosis, and dehiscence, after mastectomy. METHODS We reviewed medical records for 275 randomly selected women who were coded in the claims data for mastectomy with or without immediate breast reconstruction and had an ICD-9-CM diagnosis code for a wound complication within 180 days after surgery...
December 15, 2016: Infection Control and Hospital Epidemiology
https://www.readbyqxmd.com/read/27957534/deforestation-driven-food-web-collapse-linked-to-emerging-tropical-infectious-disease-mycobacterium-ulcerans
#16
Aaron L Morris, Jean-François Guégan, Demetra Andreou, Laurent Marsollier, Kevin Carolan, Marie Le Croller, Daniel Sanhueza, Rodolphe E Gozlan
Generalist microorganisms are the agents of many emerging infectious diseases (EIDs), but their natural life cycles are difficult to predict due to the multiplicity of potential hosts and environmental reservoirs. Among 250 known human EIDs, many have been traced to tropical rain forests and specifically freshwater aquatic systems, which act as an interface between microbe-rich sediments or substrates and terrestrial habitats. Along with the rapid urbanization of developing countries, population encroachment, deforestation, and land-use modifications are expected to increase the risk of EID outbreaks...
December 2016: Science Advances
https://www.readbyqxmd.com/read/27931301/corticosteroid-related-toxicity-in-patients-with-chronic-idiopathic-urticariachronic-spontaneous-urticaria
#17
Dennis Ledford, Michael S Broder, Evgeniya Antonova, Theodore A Omachi, Eunice Chang, Allan Luskin
BACKGROUND: Treatments for patients with chronic idiopathic urticaria (CIU)chronic spontaneous urticaria (CSU) who were unresponsive to antihistamines include oral corticosteroids (OCS). Risks of OCS-related side effects in these patients have not been described quantitatively. OBJECTIVE: To investigate the relationship between OCS use and the risk of developing side effects possibly attributable to OCS and associated health care costs in privately insured patients with CIU/CSU...
November 2016: Allergy and Asthma Proceedings:
https://www.readbyqxmd.com/read/27931204/web-based-infectious-disease-surveillance-systems-and-public-health-perspectives-a-systematic-review
#18
Jihye Choi, Youngtae Cho, Eunyoung Shim, Hyekyung Woo
BACKGROUND: Emerging and re-emerging infectious diseases are a significant public health concern, and early detection and immediate response is crucial for disease control. These challenges have led to the need for new approaches and technologies to reinforce the capacity of traditional surveillance systems for detecting emerging infectious diseases. In the last few years, the availability of novel web-based data sources has contributed substantially to infectious disease surveillance...
December 8, 2016: BMC Public Health
https://www.readbyqxmd.com/read/27928005/amino-acid-mutations-in-the-ns4a-region-of-hepatitis-c-virus-contribute-to-viral-replication-and-infectious-virus-production
#19
Asako Murayama, Nao Sugiyama, Ryosuke Suzuki, Masaki Moriyama, Noriko Nakamura, Hidenori Mochizuki, Takaji Wakita, Takanobu Kato
: Hepatitis C Virus (HCV) strain JFH-1, which belongs to genotype 2a, replicates autonomously in cultured cells, whereas another genotype 2a strain, J6CF, does not. Previously, we found that replacing the NS3 helicase and NS5B-to-3' X regions of J6CF with those of JFH-1 confers J6CF replication competence. In this study, we aimed to identify the minimum modifications to establish replication-competent J6CF within these genomic regions. We previously identified 4 mutations in the NS5B-to-3' X region that confer J6CF replication competence instead of replacing of this region...
December 7, 2016: Journal of Virology
https://www.readbyqxmd.com/read/27922168/update-of-the-swiss-guidelines-on-post-treatment-lyme-disease-syndrome
#20
Johannes Nemeth, Enos Bernasconi, Ulrich Heininger, Mohamed Abbas, David Nadal, Carol Strahm, Stefan Erb, Stefan Zimmerli, Hansjakob Furrer, Julie Delaloye, Thierry Kuntzer, Ekkehard Altpeter, Mathias Sturzenegger, Rainer Weber, For The Swiss Society For Infectious Diseases And The Swiss Society For Neurology
Lyme borreliosis is caused by Borrelia burgdorferi sensu lato infection, which responds well to antibiotic therapy in the overwhelming majority of cases. However, despite adequate antibiotic treatment some patients report persisting symptoms which are commonly summarised as post-treatment Lyme disease syndrome (PTLDS). In 2005, the Swiss Society of Infectious Diseases published a case definition for PTLDS. We aimed to review the scientific literature with a special emphasis on the last 10 years, questioning whether the definitions from 2005 are still valid in the light of current knowledge...
2016: Swiss Medical Weekly
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