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https://www.readbyqxmd.com/read/28089609/de-immunized-and-functional-therapeutic-deft-versions-of-a-long-lasting-recombinant-alpha-interferon-for-antiviral-therapy
#1
Eduardo F Mufarrege, Sofía Giorgetti, Marina Etcheverrigaray, Frances Terry, William Martin, Anne S De Groot
Interferon α (IFN-α) exerts potent antiviral, immunomodulatory, and antiproliferative activity and have proven clinical utility in chronic hepatitis B and C virus infections. However, repeated IFN-α administration induces neutralizing antibodies (NAb) against the therapeutic in a significant number of patients. Associations between IFN-α immunogenicity and loss of efficacy have been described. So as to improve the in vivo biological efficacy of IFN-α, a long lasting hyperglycosylated protein (4N-IFN) derived from IFN-α2b wild type (WT-IFN) was developed...
January 10, 2017: Clinical Immunology: the Official Journal of the Clinical Immunology Society
https://www.readbyqxmd.com/read/28076290/tailored-interactive-sequences-for-continuous-mr-image-guided-freehand-biopsies-of-different-organs-in-an-open-system-at-1-0-tesla-t-initial-experience
#2
Florian Streitparth, Christian Althoff, Martin Jonczyk, Felix Guettler, Martin Maurer, Hendrik Rathke, Keno Moritz Sponheuer, Bernd Hamm, Ulf K Teichgräber, Maximilian de Bucourt
OBJECTIVES: To assess the feasibility, image quality, and accuracy of freehand biopsies of liver, bone, muscle, vertebral disc, soft tissue, and other lesions using balanced steady-state free precession (SSFP, balanced fast field echo: bFFE), spoiled and nonspoiled gradient echo (FFE), and turbo spin echo (TSE) sequences for interactive continuous navigation in an open magnetic resonance imaging (MRI) system at 1.0 tesla (T). METHODS: Twenty-six MR-guided biopsies (five liver, five bone, four muscle, four vertebral disc, one lung, one kidney, one suprarenal gland, and five soft or other tissue) were performed in 23 patients in a 1...
January 11, 2017: Biomedizinische Technik. Biomedical Engineering
https://www.readbyqxmd.com/read/28048356/su-g-tep4-13-interfraction-treatment-monitoring-using-integrated-invivo-epid-images
#3
D Defoor, N Papanikolaou, S Stathakis
PURPOSE: To investigate inter-fraction differences of dose delivery by analyzing portal images acquired during treatment and implement an automated system to generate a report for each fraction. Large differences in images between fractions can alert the physicist of possible machine performance issues or patient set-up errors. METHODS: A Varian Novalis Tx equipped with a HD120 MLC and aS1000 electronic portal imaging device (EPID) was used in our study. EPID images are acquired in continuous acquisition mode for 32 volumetric arc therapy (VMAT) patients...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/27972911/fabrication-of-anti-vitiligo-ointment-containing-psoralia-corylifolia-invitro-and-invivo-characterization
#4
I Hussain, N Hussain, A Manan, B Ali, A Rashid
No abstract text is available yet for this article.
November 2016: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
https://www.readbyqxmd.com/read/27800485/clinical-application-of-cone-beam-computed-tomography-of-the-rabbit-head-part-1-normal-dentition
#5
G G Riggs, Boaz Arzi, Derek D Cissell, David C Hatcher, Philip H Kass, Amy Zhen, Frank J M Verstraete
Domestic rabbits (Oryctolagus cuniculus) are increasingly popular as household pets; therefore, veterinarians need to be familiar with the most common diseases afflicting rabbits including dental diseases. Diagnostic approaches for dental disease include gross oral examination, endoscopic oral examination, skull radiography, and computed tomography (CT). CT overcomes many limitations of standard radiography by permitting cross-sectional images of the rabbit head in multiple planes without superimposition of anatomic structures...
2016: Frontiers in Veterinary Science
https://www.readbyqxmd.com/read/27725960/drug-delivery-via-cell-membrane-fusion-using-lipopeptide-modified-liposomes
#6
Jian Yang, Azadeh Bahreman, Geert Daudey, Jeroen Bussmann, René C L Olsthoorn, Alexander Kros
Efficient delivery of drugs to living cells is still a major challenge. Currently, most methods rely on the endocytotic pathway resulting in low delivery efficiency due to limited endosomal escape and/or degradation in lysosomes. Here, we report a new method for direct drug delivery into the cytosol of live cells in vitro and invivo utilizing targeted membrane fusion between liposomes and live cells. A pair of complementary coiled-coil lipopeptides was embedded in the lipid bilayer of liposomes and cell membranes respectively, resulting in targeted membrane fusion with concomitant release of liposome encapsulated cargo including fluorescent dyes and the cytotoxic drug doxorubicin...
September 28, 2016: ACS Central Science
https://www.readbyqxmd.com/read/27720400/evaluation-of-quail-and-turkey-egg-yolk-for-cryopreservation-of-nili-ravi-buffalo-bull-semen
#7
S Akhter, B A Rakha, M S Ansari, A U Husna, S Iqbal, M Khalid
Egg yolk is used as a cryoprotectant for semen in different mammalian species including buffalo. Egg yolk from different sources may affect freezability of buffalo bull semen. Quail egg yolk (QEY) and turkey egg yolk (TEY) in Tris-citric acid extender was evaluated for post-thaw quality and in vivo fertility rate of cryopreserved buffalo bull semen. Ejaculates were collected on weekly basis from six Nili-Ravi buffalo bulls (12 ejaculates/bull) for a period of 6 weeks and diluted at 37 °C with tris-citric egg yolk extender (50 × 10(6) motile spermatozoa mL(-1)) containing different levels of QEY or TEY (5%, 10%, 15%, and 20%) or 20% chicken egg yolk (CEY; controls) and cryopreserved...
January 1, 2017: Theriogenology
https://www.readbyqxmd.com/read/27692837/central-zone-lesions-on-magnetic-resonance-imaging-should-we-be-concerned
#8
Wei Phin Tan, Andrew Mazzone, Stephanie Shors, Nency Antoine, Shahid Ekbal, Narendra Khare, Charles McKiel, Dennis Pessis, Leslie Deane
INTRODUCTION AND OBJECTIVE: The Prostate Imaging Reporting and Data System (PI-RADS) score was developed to evaluate lesions in the peripheral and transition zone on multiparametric magnetic resonance imaging (mpMRI) of the prostate. We aim to determine if the PI-RADS scoring system can be used to evaluate central zone lesions on mpMRI. MATERIALS AND METHODS: A retrospective review of 73 patients who underwent mpMRI/ultrasound (US) fusion-guided biopsy of 143 suspicious lesions between February 2014 and October 2015 was performed...
January 2017: Urologic Oncology
https://www.readbyqxmd.com/read/27607115/novel-three-dimensional-understanding-of-maxillary-cleft-distraction
#9
Stephen Michael Vaughan, Chung How Kau, Peter Daniel Waite
OBJECTIVES: To set forth a universal standard methodology for quantifying volumetric and linear changes in the craniofacial complex, utilizing three-dimensional data captured from a cleft-lip palate patient who underwent rigid external device (RED) distraction. METHODS: Cone beam computed tomography images of a 14-year-old patient were captured using a Kodak 9500 (Atlanta, GA) Cone Beam system device and a stereophotogrammetric system (3dMDface(TM) Atlanta, GA)...
September 2016: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/27592523/periprostatic-fat-a-risk-factor-for-prostate-cancer
#10
Wei Phin Tan, Carol Lin, Meri Chen, Leslie A Deane
OBJECTIVE: To evaluate whether periprostatic fat volume and periprostatic fat ratio as determined by multiparametric magnetic resonance imaging (mpMRI) correlate with the presence of high-grade prostate cancer. MATERIALS AND METHODS: A total of 295 consecutive patients (median age: 64, range: 38-84) underwent mpMRI of the prostate gland between August 2013 and February 2015. All patients underwent a 3 Tesla mpMRI. Using DynaCAD (Invivo, Gainesville, FL), we calculated the prostate volume and volume of the periprostatic fat seen on mpMRI...
September 1, 2016: Urology
https://www.readbyqxmd.com/read/27513266/three-dimensional-cephalometric-norms-of-turkish-cypriots-using-cbctimages-reconstructed-from-a-volumetric-rendering-program-in-vivo
#11
Levent Vahdettin, Seçil Aksoy, Ulaş Öz, Kaan Orhan
BACKGROUND/AIM: The aim of this study was to create a database of 3D cephalometric measurements of Turkish Cypriot patients using a 3D rendering software program. MATERIALS AND METHODS: The study population comprised 121 subjects who had undergone cone beam CT imaging (CBCT). Invivo 5.1 software was used to generate cephalograms from the CBCT dataset that were then linked to the 3D hard-tissue surface representations. In total, 38 angular and 28 linear widely used measurements were recorded...
2016: Turkish Journal of Medical Sciences
https://www.readbyqxmd.com/read/27509927/pleiotropic-roles-of-metalloproteinases-in-hematological-malignancies-an-update
#12
REVIEW
Ajay K Chaudhary, Shruti Chaudhary, Kanjaksha Ghosh, A Nadkarni
Controlled remodeling of the extracellular matrix (ECM) is essential for cell growth, invasion and metastasis. Matrix metalloproteinases (MMPs) are a family of secreted, zincdependent endopeptidases capable of degradation of ECM components. The expression and activity of MMPs in a variety of human cancers have been intensively studied. They play important roles at different steps of malignant tumor formation and have central significance in embryogenesis, tissue remodeling, inflammation, angiogenesis and metastasis...
2016: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/27504419/evaluation-of-antifungal-efficacy-of-ethanolic-crude-lawsone-and-listerine-mouthwash-in-uncontrolled-diabetics-and-denture-wearers-a-randomized-clinical-trial
#13
Bhavana Sujanamulk, Rajalakshmi Chintamaneni, Anuradha Chennupati, Prashant Nahar, Rattaiah Setty Chaluvadi, Ramakrishna Vemugunta, Meka Venkata Poorna Prabhat
INTRODUCTION: Lawsonia Inermis (LI) is a shrub cultivated throughout India. Many in vitro studies have been done on antifungal activity of LI, although none of the studies have been conducted invivo. AIM: To evaluate the antifungal efficacy of ethanolic extract of crude lawsone in comparison with listerine mouth wash in known diabetics and wearing dentures. MATERIALS AND METHODS: A total of 60 subjects were taken and randomly divided into two groups of 30 each...
June 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/27501037/ligand-anchored-poly-propyleneimine-dendrimers-for-brain-targeting-comparative-in-vitro-and-in-vivo-assessment
#14
Hemant K Patel, Virendra Gajbhiye, Prashant Kesharwani, Narendra K Jain
The present investigation was aimed at developing various ligands-anchored dendrimers and comparing their brain targeting potential at one platform. Sialic acid (S), glucosamine (G) and concanavalin A (C) anchored poly(propyleneimine) (PPI) dendritic nanoconjugates were developed and evaluated for delivery of anti-cancer drug, paclitaxel (PTX) to the brain. MTT assay on U373MG human astrocytoma cells indicated IC50 values of 0.40, 0.65, 0.95, 2.00 and 3.50μM for PTX loaded SPPI, GPPI, CPPI, PPI formulations, and free PTX, respectively...
November 15, 2016: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/27452486/new-mechanical-thrombectomy-model-in-the-rabbit-a-feasibility-study
#15
T Haider, R Plasenzotti, H Bergmeister, G Mach, G Kleinpeter, M Aguilar-Perez, C Sherif
BACKGROUND AND PURPOSE: Thrombolytic therapy represented the gold standard for the treatment of ischemic stroke. Its drawbacks include increased bleeding risk and low recanalization rates. Mechanical thrombectomy is a new promising therapy option. Devices used for this procedure were substantially improved during recent years. New devices require extensive preclinical invivo testing. We therefore sought to translate the commonly used pig model to a simplified and cheaper rabbit model...
September 15, 2016: Journal of Neuroscience Methods
https://www.readbyqxmd.com/read/27445214/antioxidant-effects-of-alfalfa-can-improve-iron-oxide-nanoparticle-damage-invivo-and-invitro-studies
#16
Leila Sadeghi, Farzeen Tanwir, Vahid Yousefi Babadi
Medicago sativa Linn. or alfalfa (Leguminosae) has been used traditionally as an effective cure for CNS, heart and metabolic disorders and digestive aids. Alfalfa is a resistant plant against stress due to small antioxidant molecules and enzymes. Our previous work demonstrated that 100 μg/ml of 50 nm size Fe2O3-NP causes harsh oxidative stress in HepG2 cells and 100 mg/kg of same nanoparticle causes extreme damage in rat's liver. Therefore it can be used as a useful model for invivo and invitro studies of oxidative stress...
November 2016: Regulatory Toxicology and Pharmacology: RTP
https://www.readbyqxmd.com/read/27364216/relationship-of-maxillary-3-dimensional-posterior-occlusal-plane-to-mandibular-spatial-position-and-morphology
#17
Jorge C Coro, Roberto L Velasquez, Ivette M Coro, Timothy T Wheeler, Susan P McGorray, Sadao Sato
INTRODUCTION: The purpose of this study was to examine the relationship of the 3-dimensional (3D) posterior occlusal plane (POP) and the mandibular 3D spatial position. The relationship of the POP to mandibular morphology was also investigated. METHODS: Retrospective data from a convenience sample of pretreatment diagnostic cone-beam computed tomography scans were rendered using InVivo software (Anatomage, San Jose, Calif). The sample consisted of 111 subjects (51 male, 60 female) and included growing and nongrowing subjects of different races and ethnicities...
July 2016: American Journal of Orthodontics and Dentofacial Orthopedics
https://www.readbyqxmd.com/read/27337924/-three-dimensional-survey-of-the-whole-mandibular-canal-and-mandibular-morphology-by-cone-beam-computed-tomography-in-normal-young-people
#18
Lanlan Sheng, Weiguo Qu, Yang Li, Zhenyu Qu, Ji Wang
OBJECTIVE: This research aimed to analyze the three-dimensional position of mandibular canal (MC) and man of MC and its relationship with the surrounding structures dibular morphology of normal young males and females by using data from cone beam computed tomography (CBCT), as well as to provide an anatomical basis for clinical surgery of the mandible. METHODS: Normal occlusion and CBCT scans of 29 normal young people were conducted. InVivo 5 software was used to reconstruct the mandible, anchor the points, and measure the jaw shape and three-dimensional course of MC...
April 2016: Hua Xi Kou Qiang Yi Xue za Zhi, Huaxi Kouqiang Yixue Zazhi, West China Journal of Stomatology
https://www.readbyqxmd.com/read/27276111/bone-reduction-to-facilitate-immediate-implant-placement-and-loading-using-cad-cam-surgical-guides-for-patients-with-terminal-dentition
#19
Fawaz Alzoubi, Nima Massoomi, Anders Nattestad
The aim of this study is to present a method, using 3 computer-aided design/computer-aided manufacturing (CAD/CAM) surgical guides, to accurately obtain the desired bone reduction followed by immediate implant placements and loading for patients diagnosed with terminal dentition. Patients who had bone reduction, implants placed, and immediate loading using Anatomage Invivo 5 CAD/CAM surgical guides between the period 2013 and 2015 were evaluated retrospectively. Patients diagnosed with terminal dentition and treated using the "3-guide technique" were identified...
October 2016: Journal of Oral Implantology
https://www.readbyqxmd.com/read/27266995/accuracy-assessment-of-immediate-and-delayed-implant-placements-using-cad-cam-surgical-guides
#20
Fawaz Alzoubi, Nima Massoomi, Anders Nattestad
The aim of this study is to assess the accuracy of immediately placed implants using Anatomage Invivo5 computer-assisted design/computer-assisted manufacturing (CAD/CAM) surgical guides and compare the accuracy to delayed implant placement protocol. Patients who had implants placed using Anatomage Invivo5 CAD/CAM surgical guides during the period of 2012-2015 were evaluated retrospectively. Patients who received immediate implant placements and/or delayed implant placements replacing 1-2 teeth were included in this study...
October 2016: Journal of Oral Implantology
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