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https://www.readbyqxmd.com/read/28267666/rf-inhomogeneity-compensation-using-method-of-fourier-synthesis
#1
Navin Khaneja
In this paper, we propose a new method for design of composite pulses that are robust to rf-amplitude (rf-inhomogeneity). We call this, the method of Fourier synthesis. The method is general enough to design excitation, inversion, refocusing or arbitary flip angle pulses that are robust to rf-amplitude. The method can be tailored to have amplitude selective excitation. We experimentally show rf-compensation over a order of magnitude (20db) variation in rf-amplitude. The method is expected to find use in invivo NMR studies using surface coils, where there is large dispersion in rf-amplitude over the sample...
February 15, 2017: Journal of Magnetic Resonance
https://www.readbyqxmd.com/read/28223335/cooperation-of-musashi-2-numb-mdm2-and-p53-in-drug-resistance-and-malignant-biology-of-pancreatic-cancer
#2
Weiwei Sheng, Ming Dong, Chuanping Chen, Zixin Wang, Yunwei Li, Kewei Wang, Yuji Li, Jianping Zhou
Our earlier work showed that Musashi (MSI)-2 promoted the development of pancreatic cancer (PC) by down-regulating Numb, which prevented murine double-minute (MDM)-2-mediated p53 ubiquitin degradation. Thus, we investigate the relationship among MSI2, Numb, MDM2, and p53 in PC in vitro and invivo, an association that has not been reported to our knowledge. MSI2 had no relationship with mutant p53 (mtp53) and wild-type p53 (wtp53) in normal PC cells. However, in response to gemcitabine or cisplatin treatment, MSI2 silencing simultaneously down-regulated MDM2 and up-regulated Numb and wtp53 protein levels...
February 21, 2017: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/28193696/astrocytic-orosomucoid-2-modulates-microglial-activation-and-neuroinflammation
#3
Myungjin Jo, Jong-Heon Kim, Gyunjee Song, Minchul Seo, Eun Mi Hwang, Kyoungho Suk
Orosomucoid (ORM) is an acute-phase protein that belongs to the immunocalin subfamily, a group of small-molecule binding proteins with immunomodulatory functions. Little is known about the role of ORM proteins in the central nervous system. The aim of the present study was to investigate the brain expression of ORM and its role in neuroinflammation. Expression of Orm2, but not Orm1 or Orm3, was highly induced in the mouse brain after systemic injection of lipopolysaccharide (LPS). Plasma levels of ORM2 were also significantly higher in patients with cognitive impairment than in normal subjects...
February 13, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/28179526/a-sequence-independent-unstructured-ires-is-responsible-for-internal-expression-of-the-coat-protein-of-turnip-crinkle-virus
#4
Jared May, Philip Johnson, Huma Saleem, Anne E Simon
To maximize the coding potential of viral genomes, internal ribosome entry sites (IRES) can be used to bypass the traditional requirement of a 5' cap and some/all of the associated translation initiation factors. Although viral IRES typically contain higher order RNA structure, an unstructured sequence of about 84-nt immediately upstream of the Turnip crinkle virus (TCV) coat protein (CP) ORF has been found to promote internal expression of the CP from the genomic (g)RNA both in vitro and in vivo Absence of extensive RNA structure was predicted using RNA folding algorithms and confirmed by SHAPE structure probing...
February 8, 2017: Journal of Virology
https://www.readbyqxmd.com/read/28089609/de-immunized-and-functional-therapeutic-deft-versions-of-a-long-lasting-recombinant-alpha-interferon-for-antiviral-therapy
#5
Eduardo F Mufarrege, Sofía Giorgetti, Marina Etcheverrigaray, Frances Terry, William Martin, Anne S De Groot
Interferon α (IFN-α) exerts potent antiviral, immunomodulatory, and antiproliferative activity and have proven clinical utility in chronic hepatitis B and C virus infections. However, repeated IFN-α administration induces neutralizing antibodies (NAb) against the therapeutic in a significant number of patients. Associations between IFN-α immunogenicity and loss of efficacy have been described. So as to improve the in vivo biological efficacy of IFN-α, a long lasting hyperglycosylated protein (4N-IFN) derived from IFN-α2b wild type (WT-IFN) was developed...
January 10, 2017: Clinical Immunology: the Official Journal of the Clinical Immunology Society
https://www.readbyqxmd.com/read/28076290/tailored-interactive-sequences-for-continuous-mr-image-guided-freehand-biopsies-of-different-organs-in-an-open-system-at-1-0-tesla-t-initial-experience
#6
Florian Streitparth, Christian Althoff, Martin Jonczyk, Felix Guettler, Martin Maurer, Hendrik Rathke, Keno Moritz Sponheuer, Bernd Hamm, Ulf K Teichgräber, Maximilian de Bucourt
OBJECTIVES: To assess the feasibility, image quality, and accuracy of freehand biopsies of liver, bone, muscle, vertebral disc, soft tissue, and other lesions using balanced steady-state free precession (SSFP, balanced fast field echo: bFFE), spoiled and nonspoiled gradient echo (FFE), and turbo spin echo (TSE) sequences for interactive continuous navigation in an open magnetic resonance imaging (MRI) system at 1.0 tesla (T). METHODS: Twenty-six MR-guided biopsies (five liver, five bone, four muscle, four vertebral disc, one lung, one kidney, one suprarenal gland, and five soft or other tissue) were performed in 23 patients in a 1...
January 11, 2017: Biomedizinische Technik. Biomedical Engineering
https://www.readbyqxmd.com/read/28048356/su-g-tep4-13-interfraction-treatment-monitoring-using-integrated-invivo-epid-images
#7
D Defoor, N Papanikolaou, S Stathakis
PURPOSE: To investigate inter-fraction differences of dose delivery by analyzing portal images acquired during treatment and implement an automated system to generate a report for each fraction. Large differences in images between fractions can alert the physicist of possible machine performance issues or patient set-up errors. METHODS: A Varian Novalis Tx equipped with a HD120 MLC and aS1000 electronic portal imaging device (EPID) was used in our study. EPID images are acquired in continuous acquisition mode for 32 volumetric arc therapy (VMAT) patients...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/27972911/fabrication-of-anti-vitiligo-ointment-containing-psoralia-corylifolia-invitro-and-invivo-characterization
#8
I Hussain, N Hussain, A Manan, B Ali, A Rashid
No abstract text is available yet for this article.
November 2016: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
https://www.readbyqxmd.com/read/27800485/clinical-application-of-cone-beam-computed-tomography-of-the-rabbit-head-part-1-normal-dentition
#9
G G Riggs, Boaz Arzi, Derek D Cissell, David C Hatcher, Philip H Kass, Amy Zhen, Frank J M Verstraete
Domestic rabbits (Oryctolagus cuniculus) are increasingly popular as household pets; therefore, veterinarians need to be familiar with the most common diseases afflicting rabbits including dental diseases. Diagnostic approaches for dental disease include gross oral examination, endoscopic oral examination, skull radiography, and computed tomography (CT). CT overcomes many limitations of standard radiography by permitting cross-sectional images of the rabbit head in multiple planes without superimposition of anatomic structures...
2016: Frontiers in Veterinary Science
https://www.readbyqxmd.com/read/27725960/drug-delivery-via-cell-membrane-fusion-using-lipopeptide-modified-liposomes
#10
Jian Yang, Azadeh Bahreman, Geert Daudey, Jeroen Bussmann, René C L Olsthoorn, Alexander Kros
Efficient delivery of drugs to living cells is still a major challenge. Currently, most methods rely on the endocytotic pathway resulting in low delivery efficiency due to limited endosomal escape and/or degradation in lysosomes. Here, we report a new method for direct drug delivery into the cytosol of live cells in vitro and invivo utilizing targeted membrane fusion between liposomes and live cells. A pair of complementary coiled-coil lipopeptides was embedded in the lipid bilayer of liposomes and cell membranes respectively, resulting in targeted membrane fusion with concomitant release of liposome encapsulated cargo including fluorescent dyes and the cytotoxic drug doxorubicin...
September 28, 2016: ACS Central Science
https://www.readbyqxmd.com/read/27720400/evaluation-of-quail-and-turkey-egg-yolk-for-cryopreservation-of-nili-ravi-buffalo-bull-semen
#11
S Akhter, B A Rakha, M S Ansari, A U Husna, S Iqbal, M Khalid
Egg yolk is used as a cryoprotectant for semen in different mammalian species including buffalo. Egg yolk from different sources may affect freezability of buffalo bull semen. Quail egg yolk (QEY) and turkey egg yolk (TEY) in Tris-citric acid extender was evaluated for post-thaw quality and in vivo fertility rate of cryopreserved buffalo bull semen. Ejaculates were collected on weekly basis from six Nili-Ravi buffalo bulls (12 ejaculates/bull) for a period of 6 weeks and diluted at 37 °C with tris-citric egg yolk extender (50 × 10(6) motile spermatozoa mL(-1)) containing different levels of QEY or TEY (5%, 10%, 15%, and 20%) or 20% chicken egg yolk (CEY; controls) and cryopreserved...
January 1, 2017: Theriogenology
https://www.readbyqxmd.com/read/27692837/central-zone-lesions-on-magnetic-resonance-imaging-should-we-be-concerned
#12
Wei Phin Tan, Andrew Mazzone, Stephanie Shors, Nency Antoine, Shahid Ekbal, Narendra Khare, Charles McKiel, Dennis Pessis, Leslie Deane
INTRODUCTION AND OBJECTIVE: The Prostate Imaging Reporting and Data System (PI-RADS) score was developed to evaluate lesions in the peripheral and transition zone on multiparametric magnetic resonance imaging (mpMRI) of the prostate. We aim to determine if the PI-RADS scoring system can be used to evaluate central zone lesions on mpMRI. MATERIALS AND METHODS: A retrospective review of 73 patients who underwent mpMRI/ultrasound (US) fusion-guided biopsy of 143 suspicious lesions between February 2014 and October 2015 was performed...
January 2017: Urologic Oncology
https://www.readbyqxmd.com/read/27607115/novel-three-dimensional-understanding-of-maxillary-cleft-distraction
#13
Stephen Michael Vaughan, Chung How Kau, Peter Daniel Waite
OBJECTIVES: To set forth a universal standard methodology for quantifying volumetric and linear changes in the craniofacial complex, utilizing three-dimensional data captured from a cleft-lip palate patient who underwent rigid external device (RED) distraction. METHODS: Cone beam computed tomography images of a 14-year-old patient were captured using a Kodak 9500 (Atlanta, GA) Cone Beam system device and a stereophotogrammetric system (3dMDface(TM) Atlanta, GA)...
September 2016: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/27592523/periprostatic-fat-a-risk-factor-for-prostate-cancer
#14
Wei Phin Tan, Carol Lin, Meri Chen, Leslie A Deane
OBJECTIVE: To evaluate whether periprostatic fat volume and periprostatic fat ratio as determined by multiparametric magnetic resonance imaging (mpMRI) correlate with the presence of high-grade prostate cancer. MATERIALS AND METHODS: A total of 295 consecutive patients (median age: 64, range: 38-84) underwent mpMRI of the prostate gland between August 2013 and February 2015. All patients underwent a 3 Tesla mpMRI. Using DynaCAD (Invivo, Gainesville, FL), we calculated the prostate volume and volume of the periprostatic fat seen on mpMRI...
September 1, 2016: Urology
https://www.readbyqxmd.com/read/27513266/three-dimensional-cephalometric-norms-of-turkish-cypriots-using-cbctimages-reconstructed-from-a-volumetric-rendering-program-in-vivo
#15
Levent Vahdettin, Seçil Aksoy, Ulaş Öz, Kaan Orhan
BACKGROUND/AIM: The aim of this study was to create a database of 3D cephalometric measurements of Turkish Cypriot patients using a 3D rendering software program. MATERIALS AND METHODS: The study population comprised 121 subjects who had undergone cone beam CT imaging (CBCT). Invivo 5.1 software was used to generate cephalograms from the CBCT dataset that were then linked to the 3D hard-tissue surface representations. In total, 38 angular and 28 linear widely used measurements were recorded...
2016: Turkish Journal of Medical Sciences
https://www.readbyqxmd.com/read/27509927/pleiotropic-roles-of-metalloproteinases-in-hematological-malignancies-an-update
#16
REVIEW
Ajay K Chaudhary, Shruti Chaudhary, Kanjaksha Ghosh, A Nadkarni
Controlled remodeling of the extracellular matrix (ECM) is essential for cell growth, invasion and metastasis. Matrix metalloproteinases (MMPs) are a family of secreted, zincdependent endopeptidases capable of degradation of ECM components. The expression and activity of MMPs in a variety of human cancers have been intensively studied. They play important roles at different steps of malignant tumor formation and have central significance in embryogenesis, tissue remodeling, inflammation, angiogenesis and metastasis...
2016: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/27504419/evaluation-of-antifungal-efficacy-of-ethanolic-crude-lawsone-and-listerine-mouthwash-in-uncontrolled-diabetics-and-denture-wearers-a-randomized-clinical-trial
#17
Bhavana Sujanamulk, Rajalakshmi Chintamaneni, Anuradha Chennupati, Prashant Nahar, Rattaiah Setty Chaluvadi, Ramakrishna Vemugunta, Meka Venkata Poorna Prabhat
INTRODUCTION: Lawsonia Inermis (LI) is a shrub cultivated throughout India. Many in vitro studies have been done on antifungal activity of LI, although none of the studies have been conducted invivo. AIM: To evaluate the antifungal efficacy of ethanolic extract of crude lawsone in comparison with listerine mouth wash in known diabetics and wearing dentures. MATERIALS AND METHODS: A total of 60 subjects were taken and randomly divided into two groups of 30 each...
June 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/27501037/ligand-anchored-poly-propyleneimine-dendrimers-for-brain-targeting-comparative-in-vitro-and-in-vivo-assessment
#18
Hemant K Patel, Virendra Gajbhiye, Prashant Kesharwani, Narendra K Jain
The present investigation was aimed at developing various ligands-anchored dendrimers and comparing their brain targeting potential at one platform. Sialic acid (S), glucosamine (G) and concanavalin A (C) anchored poly(propyleneimine) (PPI) dendritic nanoconjugates were developed and evaluated for delivery of anti-cancer drug, paclitaxel (PTX) to the brain. MTT assay on U373MG human astrocytoma cells indicated IC50 values of 0.40, 0.65, 0.95, 2.00 and 3.50μM for PTX loaded SPPI, GPPI, CPPI, PPI formulations, and free PTX, respectively...
November 15, 2016: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/27452486/new-mechanical-thrombectomy-model-in-the-rabbit-a-feasibility-study
#19
T Haider, R Plasenzotti, H Bergmeister, G Mach, G Kleinpeter, M Aguilar-Perez, C Sherif
BACKGROUND AND PURPOSE: Thrombolytic therapy represented the gold standard for the treatment of ischemic stroke. Its drawbacks include increased bleeding risk and low recanalization rates. Mechanical thrombectomy is a new promising therapy option. Devices used for this procedure were substantially improved during recent years. New devices require extensive preclinical invivo testing. We therefore sought to translate the commonly used pig model to a simplified and cheaper rabbit model...
September 15, 2016: Journal of Neuroscience Methods
https://www.readbyqxmd.com/read/27445214/antioxidant-effects-of-alfalfa-can-improve-iron-oxide-nanoparticle-damage-invivo-and-invitro-studies
#20
Leila Sadeghi, Farzeen Tanwir, Vahid Yousefi Babadi
Medicago sativa Linn. or alfalfa (Leguminosae) has been used traditionally as an effective cure for CNS, heart and metabolic disorders and digestive aids. Alfalfa is a resistant plant against stress due to small antioxidant molecules and enzymes. Our previous work demonstrated that 100 μg/ml of 50 nm size Fe2O3-NP causes harsh oxidative stress in HepG2 cells and 100 mg/kg of same nanoparticle causes extreme damage in rat's liver. Therefore it can be used as a useful model for invivo and invitro studies of oxidative stress...
November 2016: Regulatory Toxicology and Pharmacology: RTP
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