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https://www.readbyqxmd.com/read/28433512/effect-of-1-2-3-triazole-salts-non-classical-bioisosteres-of-miltefosine-on-leishmania-amazonensis
#1
Pedro H F Stroppa, Luciana M R Antinarelli, Arturene M L Carmo, Jacy Gameiro, Elaine S Coimbra, Adilson D da Silva
Here, we report the effect of new non-classical bioisosteres of miltefosine on Leishmania amazonensis. Fifteen compounds were synthesized and the compound dhmtAc, containing an acetate anion, a side chain of 10 carbon atoms linked to N-1 and a methyl group linked to N-3, showed high and selective biological activity against L. amazonensis. On the intracellular amastigotes, stages of the parasite related to human disease, the IC50 values were near or similar to the 1.0μM (0.9, 0.8 and 1.0μM on L. amazonensis-WT, and two transgenic L...
March 28, 2017: Bioorganic & Medicinal Chemistry
https://www.readbyqxmd.com/read/28433167/ammonium-pillared-montmorillonite-cofe2o4-composite-caged-in-calcium-alginate-beads-for-the-removal-of-cs-from-wastewater
#2
Xian-Ming Zheng, Jun-Feng Dou, Meng Xia, Ai-Zhong Ding
Novel and magnetic adsorbent ammonium-pillared montmorillonite-CoFe2O4 composite caged in calcium alginate beads was prepared by using non-toxic raw materials. The morphology, magnetic properties, functional groups, and crystal structure of the compound were characterized by SEM, VSM, FT-IR and XRD. The adsorption behaviors were also investigated via adsorption experiments and response surface methodology was used to optimize the operation conditions. The beads showed high selectivity for Cs(+) in the presence of Na(+) and could be rapidly separated from the mixed solution under an external magnetic field...
July 1, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/28433055/pyrenyl-carbon-nanostructures-for-ultrasensitive-measurements-of-formaldehyde-in-urine
#3
Gayan Premaratne, Sabrina Farias, Sadagopan Krishnan
Measurement of ultra-low (e.g., parts-per-billion) levels of small-molecule markers in body fluids (e.g., serum, urine, saliva) involves a considerable challenge in view of designing assay strategies with sensitivity and selectivity. Herein we report for the first time an amperometric nano-bioelectrode design that uniquely combines 1-pyrenebutyric acid units pi-pi stacked with carboxylated multiwalled carbon nanotubes on the surface of gold screen printed electrodes for covalent attachment of NAD(+) dependent formaldehyde dehydrogenase (FDH)...
June 1, 2017: Analytica Chimica Acta
https://www.readbyqxmd.com/read/28432965/spatiotemporal-description-of-btex-volatile-organic-compounds-in-a-middle-eastern-megacity-tehran-study-of-exposure-prediction-for-environmental-health-research-tehran-sepehr
#4
Heresh Amini, Vahid Hosseini, Christian Schindler, Hossein Hassankhany, Masud Yunesian, Sarah B Henderson, Nino Künzli
The spatiotemporal variability of ambient volatile organic compounds (VOCs) in Tehran, Iran, is not well understood. Here we present the design, methods, and results of the Tehran Study of Exposure Prediction for Environmental Health Research (Tehran SEPEHR) on ambient concentrations of benzene, toluene, ethylbenzene, p-xylene, m-xylene, o-xylene (BTEX), and total BTEX. To date, this is the largest study of its kind in a low- and middle-income country and one of the largest globally. We measured BTEX concentrations at five reference sites and 174 distributed sites identified by a cluster analytic method...
April 19, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/28430022/safety-by-design-of-printed-multilayer-materials-intended-for-food-packaging
#5
Celia Domeño, Margarita Aznar, Cristina Nerín, Francesca Isella, Mauro Fedeli, Osvaldo Bosetti
Printing inks are commonly used in multilayer plastics materials used for food packaging and compounds present in inks can migrate to the food either by diffusion through the multilayers or because of set-off phenomena. To avoid this problem the right design of the packaging is crucial. In this work, the safety by design of multilayer materials has been studied. First, the migration from 4 different multilayers manufactured using polyethylene terephthalate (PET), aluminium (Al) and polyethylene (PE) was determined...
April 21, 2017: Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment
https://www.readbyqxmd.com/read/28429185/high-content-assessment-of-cardiac-function-using-heart-on-a-chip-devices-as-drug-screening-model
#6
Genevieve Conant, Benjamin Fook Lun Lai, Rick Xing Ze Lu, Anastasia Korolj, Erika Yan Wang, Milica Radisic
Drug discovery and development continues to be a challenge to the pharmaceutical industry despite great advances in cell and molecular biology that allow for the design of better targeted therapeutics. Many potential drug compounds fail during the clinical trial due to inefficacy and toxicity that were not predicted during preclinical stages. The fundamental problem lies with the use of traditional drug screening models that still largely rely on the use of cell lines or animal cell monolayers, which leads to lack of predictive power of human tissue and organ response to the drug candidates...
April 20, 2017: Stem Cell Reviews
https://www.readbyqxmd.com/read/28428060/effects-of-chronic-ammonia-exposure-on-ammonia-metabolism-and-excretion-in-marine-medaka-oryzias-melastigma
#7
Na Gao, Limei Zhu, Zhiqiang Guo, Meisheng Yi, Li Zhang
Ammonia is highly toxic to aquatic organisms, but whether ammonia excretion or ammonia metabolism to less toxic compounds is the major strategy for detoxification in marine fish against chronic ammonia exposure is unclear to date. In this study, we investigated the metabolism and excretion of ammonia in marine medaka Oryzias melastigma during chronic ammonia exposure. The fish were exposed to 0, 0.1, 0.3, 0.6, and 1.1 mmol l(-1) NH4Cl spiked seawater for 8 weeks. Exposure of 0.3-1.1 mmol l(-1) NH4Cl had deleterious effects on the fish, including significant reductions in growth, feed intake, and total protein content...
April 17, 2017: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/28427843/relative-importance-of-different-exposure-routes-of-heavy-metals-for-humans-living-near-a-municipal-solid-waste-incinerator
#8
Tong Li, Yi Wan, Yujie Ben, Senrong Fan, Jianying Hu
The potential health effects of toxic chemicals (e.g. heavy metals) emitted by municipal solid waste incinerators (MSWIs) are of great concern to local residents, however there have been few studies on the contributions of different exposure pathways and their subsequent effects on the body burden of residents living near MSWIs. In this study, multiple exposure routes of heavy metals including Pb, Cr, Cd and Mn were assessed by investigating the metals in foods (such as vegetables, crops, meats and fruits etc...
April 17, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/28427645/ultrasound-assisted-extraction-of-achyrocline-satureioides-prevents-contrast-induced-nephropathy-in-mice
#9
Ketheley L Guss, Stefano Pavanni, Bruno Prati, Lucas Dazzi, Jairo P de Oliveira, Breno V Nogueira, Thiago M C Pereira, Marcio Fronza, Denise C Endringer, Rodrigo Scherer
Achyrocline satureioides or Macela, has been largely used in traditional folk medicine in Brazil as an anti-inflammatory agent and to treat various digestive disorders. The aim of the present study was to evaluate the preventive action of the extracts of A. satureioides obtained by maceration and ultrasound-assisted extraction, quercetin and N-acetylcysteine against contrast-induced nephropathy in mice. The antioxidant activity, cytotoxicity and inhibition of nitric oxide (NO) production in macrophages were evaluated...
July 2017: Ultrasonics Sonochemistry
https://www.readbyqxmd.com/read/28427570/high-resolution-mass-spectrometry-based-screening-reveals-lipophilic-toxins-in-multiple-trophic-levels-from-the-north-sea
#10
Gabriel Orellana, Lieven Van Meulebroek, Maarten De Rijcke, Colin R Janssen, Lynn Vanhaecke
Lipophilic marine biotoxins, which are mainly produced by small dinoflagellates, are increasingly detected in coastal waters across the globe. As these producers are consumed by zooplankton and shellfish, the toxins are introduced, bioaccumulated and possibly biomagnified throughout marine food chains. Recent research has demonstrated that ultra-high performance liquid chromatography coupled to high-resolution mass spectrometry (UHPLC-HRMS) is an excellent tool to detect marine toxins in algae and seafood. In this study, UHPLC-HRMS was used to screen lipophilic marine biotoxins in organisms from different trophic levels of the Belgian coastal zone ecosystem...
April 2017: Harmful Algae
https://www.readbyqxmd.com/read/28426083/energetic-isomers-of-1-2-4-5-tetrazine-bis-1-2-4-triazoles-with-low-toxicity
#11
A Shlomovich, T Pechersky, A Cohen, Q L Yan, M Kosa, N Petrutik, N Tal, A Aizikovich, M Gozin
A series of nitrogen-rich "green" Energetic Materials (EMs), some with improved sensitivity, thermostability, and very low toxicity, were synthesized on the basis of 3,5-diamino-1,2,4-triazole (DAT) and 1,2,4,5-tetrazine building blocks. Since DAT contains several nucleophilic reactive sites, obtaining selective reactivity and specific isomeric products with 1,2,4,5-tetrazine precursors is a challenging task. We developed reaction conditions under which specific isomers could be prepared. On evaluating these compounds for their energetic properties, we found that N(5),N(5)'-(1,2,4,5-tetrazine-3,6-diyl)-bis(1H-1,2,4-triazole-3,5-diamine) 1 has very high thermostability (onset of decomposition temperature at 357 °C) and it is insensitive to impact (Im > 98 J), friction (>360 N) and electrostatic discharge (2512 mJ)...
April 20, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/28421635/a-homochiral-co%C3%AE-%C3%AE-16co%C3%AE-%C3%AE-%C3%AE-4-supertetrahedral-t4-cluster-from-a-racemic-ligand-with-ferromagnetic-behavior-and-high-photocatalytic-activity
#12
Yue-Ling Bai, Wei Du, Xiuping Yin, Jianhui Fang, Shourong Zhu, Jun Tao
A homochiral mixed-valence cobalt cluster [CoΙΙ16CoΙΙΙ4(μ6-O)4(μ3-OH)12(S-bme)12(OAc)6]Cl6·5CH3OH·18H2O (1, Hbme = 1H-(benzimidazol-2-yl)ethanol) was synthesized from a racemic ligand and three cobalt salts of CoCl2·6H2O, Co(Ac)2·4H2O and Co(NO3)2·6H2O in a DMF/MeOH mixed solvent. The enantioselective coordination occurs when a large excess of cobalt ions added in the solution and only the S-configuration of the racemic ligand involved in crystallization. The CD spectra of three crystal samples show identical Cotton signals, indicating the repeatability and the enantiomeric purity of the single crystals...
April 19, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28421324/weathering-the-storm-how-lodgepole-pine-trees-survive-mountain-pine-beetle-outbreaks
#13
Nadir Erbilgin, Jonathan A Cale, Altaf Hussain, Guncha Ishangulyyeva, Jennifer G Klutsch, Ahmed Najar, Shiyang Zhao
Recent mountain pine beetle outbreaks in western North America killed millions of lodgepole pine trees, leaving few survivors. However, the mechanism underlying the ability of trees to survive bark beetle outbreaks is unknown, but likely involve phytochemicals such as monoterpenes and fatty acids that can drive beetle aggregation and colonization on their hosts. Thus, we conducted a field survey of beetle-resistant lodgepole pine (Pinus contorta) trees to retrospectively deduce whether these phytochemicals underlie their survival by comparing their chemistry to that of non-attacked trees in the same stands...
April 18, 2017: Oecologia
https://www.readbyqxmd.com/read/28421158/cytotoxicity-of-zardaverine-in-embryonal-rhabdomyosarcoma-from-a-costello-syndrome-patient
#14
Donna M Cartledge, Katherine M Robbins, Katherine M Drake, Rachel Sternberg, Deborah L Stabley, Karen W Gripp, E Anders Kolb, Katia Sol-Church, Andrew D Napper
Costello syndrome (CS) patients suffer from a very high 10% incidence of embryonal rhabdomyosarcoma (ERMS). As tools to discover targeted therapeutic leads, we used a CS patient-derived ERMS cell line (CS242 ERMS) harboring a homozygous p.G12A mutation in HRAS, and a control cell line derived from the same patient comprising non-malignant CS242 fibroblasts with a heterozygous p.G12A HRAS mutation. A library of 2,000 compounds with known pharmacological activities was screened for their effect on CS242 ERMS cell viability...
2017: Frontiers in Oncology
https://www.readbyqxmd.com/read/28419542/effect-of-nanosilver-on-metabolism-in-rainbow-trout-oncorhynchus-mykiss-an-investigation-using-different-respirometric-approaches
#15
Laura Murray, Michael D Rennie, Jon C Svendsen, Eva C Enders
Nanosilver (nAg) has been incorporated into many consumer products for its antimicrobial properties, including clothing and washing machines. Consequently, the potential for its release into aquatic environments is of significant concern. Documented toxic effects on fish include altered gene expression, gill damage, impaired gas exchange, as well as mortality at high nAg concentrations. This study reports the effects of nAg on the metabolism of Rainbow Trout (Oncorhynchus mykiss). Fish were exposed to environmentally-relevant concentrations (0...
April 17, 2017: Environmental Toxicology and Chemistry
https://www.readbyqxmd.com/read/28419309/influence-of-dietary-inclusion-of-untreated-or-heat-treated-jatropha-meal-on-productive-and-reproductive-performances-and-biochemical-blood-parameters-of-laying-japanese-quail
#16
M E Abd El-Hack, M Alagawany, S A A El-Sayed, J Fowler
Jatropha meal (JM) has been characterized as a potential animal feedstuff due to its high crude protein content and high levels of essential amino acids. However, it contains anti-nutritive and toxic compounds that may hinder its use. The present study was conducted to evaluate the effects of a dietary inclusion of raw Jatropha meal (RJM) and heat-treated Jatropha meal on the growth and production of laying Japanese quail using productive, reproductive, and biochemical blood parameters. A total number of 180 mature Japanese quail at 2 months of age (120 females and 60 males) was randomly divided into 4 treatment groups: control (0% JM); 3...
April 17, 2017: Poultry Science
https://www.readbyqxmd.com/read/28418656/informing-the-selection-of-screening-hit-series-with-in-silico-absorption-distribution-metabolism-excretion-and-toxicity-profiles
#17
John M Sanders, Douglas C Beshore, J Chris Culberson, James I Fells, Jason E Imbriglio, Hakan Gunaydin, Andrew M Haidle, Marc Labroli, Brian E Mattioni, Nunzio Sciammetta, William D Shipe, Robert P Sheridan, Linda M Suen, Andreas Verras, Abbas M Walji, Elizabeth M Joshi, Tjerk Bueters
High-throughput screening (HTS) has enabled millions of compounds to be assessed for biological activity, but challenges remain in the prioritization of hit series. While biological, absorption, distribution, metabolism, excretion, and toxicity (ADMET), purity, and structural data are routinely used to select chemical matter for further follow-up, the scarcity of historical ADMET data for screening hits limits our understanding of early hit compounds. Herein, we describe a process that utilizes a battery of in-house quantitative structure activity relationship (QSAR) models to generate in silico ADMET profiles for hit series to enable more complete characterizations of HTS chemical matter...
April 18, 2017: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28418258/high-thermoelectric-performance-in-electron-doped-agbi3s5-with-ultralow-thermal-conductivity
#18
Gangjian Tan, Shiqiang Hao, Jing Zhao, Chris Wolverton, Mercouri G Kanatzidis
We report electron-doped AgBi3S5 as a new type of high-performance non-toxic thermoelectric material. This compound features exceptionally low lattice thermal conductivities of 0.5-0.3 Wm-1K-1 in the temperature range of 300-800 K, which is ascribed to its unusual vibrational properties: "double rattling" phonon modes associated with Ag and Bi atoms. Chlorine doping at anion sites acts as an efficient electron donor, significantly enhancing the electrical properties of AgBi3S5. In the carrier concentration range (5×1018-2×1019 cm-3) investigated in this study, the trends in Seebeck coefficient can be reasonably understood using a single parabolic band model with the electron effective mass of 0...
April 18, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28417930/degradation-of-methyl-2-aminobenzoate-methyl-anthranilate-by-h%C3%A2-o%C3%A2-uv-effect-of-inorganic-anions-and-derived-radicals
#19
Grazia Maria Lanzafame, Mohamed Sarakha, Debora Fabbri, Davide Vione
This study shows that methyl 2-aminobenzoate (also known as methyl anthranilate, hereafter MA) undergoes direct photolysis under UVC and UVB irradiation and that its photodegradation is further accelerated in the presence of H₂O₂. Hydrogen peroxide acts as a source of hydroxyl radicals (·OH) under photochemical conditions and yields MA hydroxyderivatives. The trend of MA photodegradation rate vs. H₂O₂ concentration reaches a plateau because of the combined effects of H₂O₂ absorption saturation and ·OH scavenging by H₂O₂...
April 12, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28417913/comparative-study-on-the-antivirus-activity-of-shuang-huang-lian-injectable-powder-and-its-bioactive-compound-mixture-against-human-adenovirus-iii-in-vitro
#20
Qinhai Ma, Dedong Liang, Shuai Song, Qintian Yu, Chunyu Shi, Xuefeng Xing, Jia-Bo Luo
Shuang-Huang-Lian injectable powder (SHL)-a classical purified herbal preparation extracted from Scutellaria baicalensis, Lonicera japonica, and Forsythia suspense-has been used against human adenovirus III (HAdV₃) for many years. The combination herb and its major bioactive compounds, including chlorogenic acid, baicalin, and forsythia glycosides A, are effective inhibitors of the virus. However, no comprehensive studies are available on the antiviral effects of SHL against HAdV₃. Moreover, it remains unclear whether the mixture of chlorogenic acid, baicalin, and forsythia glycosides A (CBF) has enhanced antiviral activity compared with SHL...
April 12, 2017: Viruses
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