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https://www.readbyqxmd.com/read/29666522/development-of-a-novel-colorimetric-sensor-based-on-alginate-beads-for-monitoring-rainbow-trout-spoilage
#1
Marjan Majdinasab, Seyed Mohammad Hashem Hosseini, Marziyeh Sepidname, Manizheh Negahdarifar, Peiwu Li
Alginate is a non-toxic, renewable, and linear copolymer obtained from the brown algae Laminaria digitata that can be easily shaped into beads. Its good gel forming properties have made it useful for entrapping food and pharmaceutical ingredients. In this study, alginate beads were used in a novel application as a colorimetric sensor in food intelligent packaging. Colorimetric sensor was developed through entrapping red cabbage extract as a pH indicator in alginate beads. The pH indicator beads were used in rainbow trout packaging for monitoring fillets spoilage...
May 2018: Journal of Food Science and Technology
https://www.readbyqxmd.com/read/29664038/-cedrus-deodara-in-vitro-antileishmanial-efficacy-immumomodulatory-activity
#2
Shyam Narayan, Chandreshwar Prasad Thakur, Shiv Bahadur, Meenakshi Thakur, Shashi Nath Pandey, Ajit Kumar Thakur, Dipendra K Mitra, Pulok K Mukherjee
Background & objectives: The existing antileishmanial drugs for complete cure of visceral leishmaniasis (kala-azar) are limited. The available drugs are either toxic or less effective leading to disease relapse or conversion to post-kala-azar dermal leishmaniasis. Several herbal extracts have been shown to have antileishmanial activity, but a herbal drug may not always be safe. In the present study, the extract of Cedrus deodara leaves has been standardized and tested for immunomodulatory antileishmanial activities...
December 2017: Indian Journal of Medical Research
https://www.readbyqxmd.com/read/29662448/berry-phenolic-antioxidants-implications-for-human-health
#3
REVIEW
Beata Olas
Antioxidants present in the diet may have a significant effect on the prophylaxis and progression of various diseases associated with oxidative stress. Berries contain a range of chemical compounds with antioxidant properties, including phenolic compounds. The aim of this review article is to provide an overview of the current knowledge of such phenolic antioxidants, and to discuss whether these compounds may always be natural gifts for human health, based on both in vitro and in vivo studies. It describes the antioxidant properties of fresh berries (including aronia berries, grapes, blueberries, sea buckthorn berries, strawberries and other berries) and their various products, especially juices and wines...
2018: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29661755/a-cd123-targeting-antibody-drug-conjugate-imgn632-designed-to-eradicate-aml-while-sparing-normal-bone-marrow-cells
#4
Yelena Kovtun, Gregory E Jones, Sharlene Adams, Lauren Harvey, Charlene A Audette, Alan Wilhelm, Chen Bai, Lingyun Rui, Rassol Laleau, Fenghua Liu, Olga Ab, Yulius Setiady, Nicholas C Yoder, Victor S Goldmacher, Ravi V J Chari, Jan Pinkas, Thomas Chittenden
The outlook for patients with refractory/relapsed acute myeloid leukemia (AML) remains poor, with conventional chemotherapeutic treatments often associated with unacceptable toxicities, including severe infections due to profound myelosuppression. Thus there exists an urgent need for more effective agents to treat AML that confer high therapeutic indices and favorable tolerability profiles. Because of its high expression on leukemic blast and stem cells compared with normal hematopoietic stem cells and progenitors, CD123 has emerged as a rational candidate for molecularly targeted therapeutic approaches in this disease...
April 24, 2018: Blood Advances
https://www.readbyqxmd.com/read/29660719/assessment-of-endocrine-disruptors-effects-on-zebrafish-danio-rerio-embryos-by-untargeted-lc-hrms-metabolomic-analysis
#5
Elena Ortiz-Villanueva, Joaquim Jaumot, Rubén Martínez, Laia Navarro-Martín, Benjamin Piña, Romà Tauler
Bisphenol A (BPA), perfluorooctane sulfonate (PFOS), and tributyltin (TBT) are emerging endocrine disruptors (EDCs) with still poorly defined mechanisms of toxicity and metabolic effects in aquatic organisms. We used an untargeted liquid chromatography-high resolution mass spectrometry (LC-HRMS) metabolomic approach to study the effects of sub-lethal doses of these three EDCs on the metabolic profiles of zebrafish embryos exposed from 48 to 120hpf (hours post fertilization). Advanced chemometric data analysis methods were used to reveal effects on the subjacent regulatory pathways...
April 13, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29659532/genetic-heterogeneity-of-slc22-family-of-transporters-in-drug-disposition
#6
REVIEW
Elisa Lozano, Oscar Briz, Rocio I R Macias, Maria A Serrano, Jose J G Marin, Elisa Herraez
An important aspect of modern medicine is its orientation to achieve more personalized pharmacological treatments. In this context, transporters involved in drug disposition have gained well-justified attention. Owing to its broad spectrum of substrate specificity, including endogenous compounds and xenobiotics, and its strategical expression in organs accounting for drug disposition, such as intestine, liver and kidney, the SLC22 family of transporters plays an important role in physiology, pharmacology and toxicology...
April 16, 2018: Journal of Personalized Medicine
https://www.readbyqxmd.com/read/29658331/patients-exposure-to-pvc-plasticizers-from-ecmo-circuits
#7
Charlotte Fernandez-Canal, Pierre-Gabriel Pinta, Teuta Eljezi, Virginie Larbre, Sophie Kauffmann, Lionel Camilleri, Bernard Cosserant, Lise Bernard, Bruno Pereira, Jean-Michel Constantin, Gael Grimandi, Valérie Sautou
BACKGROUND: ECMO is a therapeutic act with a high risk of exposure to diethylhexylphthalate (DEHP), plasticizer from PVC tubings. The replacement of this plasticizer with alternative compounds is recommended but the risks associated with the use of new plasticizers have not been evaluated in ECMO situations. METHODS: Ex vivo ECMO models were performed with different flow rates over 6 days to evaluate the migration of plasticizers and their potential toxic risk for patient...
April 16, 2018: Expert Review of Medical Devices
https://www.readbyqxmd.com/read/29657504/safety-evaluation-of-various-vector-repellents-in-combination-with-deltamethrin-in-wistar-rats
#8
Anitha Magesh, Senthilkumar Sivanesan, Vijayaraghavan Rajagopalan, Royapuram Veeraragavan Geetha, Anitha Roy
Background: Vector repellents are used globally to avoid insect bites and control transmission of diseases. It is important to ensure safety levels of these compounds, although they are noxious to insects. Vector repellents when used in combination are known to bring additional benefits in getting rid of the harmful insects. Unfortunately, the safety levels of various vector repellents such as Deet ( N , N -diethyl- m -toluamide), Depa ( N , N -diethyl phenylacetamide), and Deb ( N , N -diethylbenzamide) are not studied in combination with the widely used pyrethroid deltamethrin (Del)...
January 2018: Journal of Pharmacy & Bioallied Sciences
https://www.readbyqxmd.com/read/29655853/total-saponins-of-albiziae-cortex-show-anti-hepatoma-carcinoma-effects-by-inducing-s-phase-arrest-and-mitochondrial-apoptosis-pathway-activation
#9
Yi Qian, Qing-Hua Han, Li-Chao Wang, Qiang Guo, Xu-Da Wang, Peng-Fei Tu, Ke-Wu Zeng, Hong Liang
ETHNOPHARMACOLOGICAL RELEVANCE: Albiziae Cortex (AC) is a widely used traditional medicine in China. It is possess various properties to treat insomnia, traumatic injuries, diuresis, sthenia, and confusion. Total saponins of Albiziae Cortex (TSAC) are the most abundant bioactive components of AC, which were reported to show significant anti-tumor effects in vivo and in vitro. But the underlying mechanism of TSAC remained to be revealed. AIM OF STUDY: In this study, we investigated the anti- hepatoma carcinoma effects and the potential mechanism of TSAC in vivo and in vitro...
April 12, 2018: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29653365/bene%C3%AF-cial-health-effects-of-lupenone-triterpene-a-review
#10
REVIEW
Feng Xu, Xulong Huang, Hongmei Wu, Xiangpei Wang
There are a large number of new structure compounds with good pharmacological activity in the natural plants, can be applied to the treatment of human diseases. Finding active ingredients from the plants is one of the important ways to develop new drugs. Triterpenes are widespread in plants, and lupenone belongs to lupane type triterpenoids. Lupenone is very common natural ingredient distributed in multi-family plants including Asteraceae, Balanophoraceae, Cactaceae, Iridaceae, Musaceae, Urticaceae, Leguminosae, Bombacaceae, etc...
April 10, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29653309/bioactive-extracellular-compounds-produced-by-the-dinoflagellate-alexandrium-minutum-are-highly-detrimental-for-oysters
#11
J Castrec, P Soudant, L Payton, D Tran, P Miner, C Lambert, N Le Goïc, A Huvet, V Quillien, F Boullot, Z Amzil, H Hégaret, C Fabioux
Blooms of the dinoflagellate Alexandrium spp., known as producers of paralytic shellfish toxins (PSTs), are regularly detected on the French coastline. PSTs accumulate into harvested shellfish species, such as the Pacific oyster Crassostrea gigas, and can cause strong disorders to consumers at high doses. The impacts of Alexandrium minutum on C. gigas have often been attributed to its production of PSTs without testing separately the effects of the bioactive extracellular compounds (BECs) with allelopathic, hemolytic, cytotoxic or ichthyotoxic properties, which can also be produced by these algae...
March 29, 2018: Aquatic Toxicology
https://www.readbyqxmd.com/read/29652184/dioxin-like-compounds-in-lake-fish-species-evaluation-by-dr-calux-bioassay
#12
S Sciuto, M Prearo, R Desiato, C Bulfon, E A V Burioli, G Esposito, C Guglielmetti, L Dell'atti, G Ru, D Volpatti, P L Acutis, F Martucci
Fish consumption is the principal source of intake of organochlorinated compounds in humans. Compared with other types of foods of animal origin, fish contain the highest levels of polychlorinated biphenyls (PCBs), polychlorinated dibenzo- p-dioxins, and polychlorinated dibenzofurans, all of which are classified as highly toxic organochlorine compounds. Currently, lakes and fish farms in northern Italy are not regularly monitored for PCBs and dioxins in areas contaminated by industrial sources, partially because of the high costs of traditional analytical methods that limit the number of samples to be analyzed...
April 13, 2018: Journal of Food Protection
https://www.readbyqxmd.com/read/29651948/therapeutic-potential-of-multifunctional-tacrine-analogues
#13
Maja Przybylowska, Szymon Kowalski, Krystyna Dzierzbicka, Iwona Inkielewicz-Stepniak
Tacrine is a potent inhibitor of cholinesterases (acetylcholinesterase and butyrylcholinesterase) that shows limiting clinical application by liver toxicity. In spite of this, analogues of tacrine are considered as model inhibitor of cholinesterases in the therapy of Alzheimer's disease. The interest in these compounds is mainly related to a high variety of their structure and biological properties. In the present review, we have described the role of cholinergic transmission and treatment strategies in Alzheimer's disease as well as the synthesis and biological activity of several recently developed classes of multifunctional tacrine analogues and hybrids, which consist a new paradigm to treat Alzheimer's disease...
April 11, 2018: Current Neuropharmacology
https://www.readbyqxmd.com/read/29650481/quantitative-and-comparative-liquid-chromatography-electrospray-ionization-mass-spectrometry-analyses-of-hydrogen-sulfide-and-thiol-metabolites-derivaitized-with-2-iodoacetanilide-isotopologues
#14
Der-Yen Lee, Wei-Chieh Huang, Ting-Jia Gu, Geen-Dong Chang
Hydrogen sulfide (H2 S), previously known as a toxic gas, is now recognized as a gasotransmitter along with nitric oxide and carbon monoxide. However, only few methods are available for quantitative determination of H2 S in biological samples. 2-Iodoacetanilide (2-IAN), a thiol-reacting agent, has been used to tag the reduced cysteine residues of proteins for quantitative proteomics and for detection of cysteine oxidation modification. In this article, we proposed a new method for quantitative analyses of H2 S and thiol metabolites using the procedure of pre-column 2-IAN derivatization coupled with liquid chromatography-electrospray ionization-mass spectrometry (LC-ESI-MS)...
April 5, 2018: Journal of Chromatography. A
https://www.readbyqxmd.com/read/29650275/metformin-for-non-small-cell-lung-cancer-patients-opportunities-and-pitfalls
#15
REVIEW
Antonin Levy, Jérôme Doyen
Despite exciting advances of the anticancer armamentarium in the recent years, mortality of non-small cell lung cancer (NSCLC) remains high and novel treatments are requisite. Therapy intensification is explored with promising, but expensive and potentially toxic new compounds. Repositioning already existing drugs for cancer treatment could save money and improve patient outcomes in specific contexts. Observational data suggest that use of the standard antidiabetic agent metformin decreases lung cancer incidence and mortality...
May 2018: Critical Reviews in Oncology/hematology
https://www.readbyqxmd.com/read/29649771/systematic-forensic-toxicological-analysis-by-liquid-chromatography-quadrupole-time-of-flight-mass-spectrometry-in-serum-and-comparison-to-gas-chromatography-mass-spectrometry
#16
Marcel Grapp, Christoph Kaufmann, Frank Streit, Lutz Binder
Comprehensive screening procedures for psychoactive agents in body fluids are an essential task in clinical and forensic toxicology. With the continuous emergence and adaption of new psychoactive substances (NPS) keeping a screening method up to date is challenging. To meet these demands, hyphenated high-resolution mass spectrometry has gained interest as extensive and expandable screening approach. Here we present a comprehensive method for systematic toxicological analysis of serum by liquid chromatography-quadrupole-time-of-flight mass spectrometry (LC-QTOF-MS) with data independent acquisition...
April 3, 2018: Forensic Science International
https://www.readbyqxmd.com/read/29649693/dry-and-wet-ozonation-of-denim-degradation-products-reaction-mechanism-toxicity-and-cytotoxicity-assessment
#17
Sarra Ben Hamida, Sidra Iftekhar, Indu Ambat, Varsha Srivastava, Mika Sillanpää, Zahra Amri, Neji Ladhari
The study aims to identify the denim ozonation by-products under different operating conditions and investigate the chemical toxicity of these compounds via the inhibitory effect of the sample on the light emission of bioluminescent bacteria (Vibriofischeri) and on human health using the HepG2 human hepatoma cell line. Various by-products in treated denim extract were detected w gas chromatography-mass spectrometry (GC-MS) analysis. The results revealed that the main oxidation by-product was isatin (1H-indole-2,3-dione), which formed in excess amounts on wet ozonated denim...
April 4, 2018: Chemosphere
https://www.readbyqxmd.com/read/29649664/autophagic-related-cell-death-of-trypanosoma-brucei-induced-by-bacteriocin-as-48
#18
Marta Martínez-García, Jean-Mathieu Bart, Jenny Campos-Salinas, Eva Valdivia, Manuel Martínez-Bueno, Elena González-Rey, Miguel Navarro, Mercedes Maqueda, Rubén Cebrián, José M Pérez-Victoria
The parasitic protozoan Trypanosoma brucei is the causative agent of human African trypanosomiasis (sleeping sickness) and nagana. Current drug therapies have limited efficacy, high toxicity and/or are continually hampered by the appearance of resistance. Antimicrobial peptides have recently attracted attention as potential parasiticidal compounds. Here, we explore circular bacteriocin AS-48's ability to kill clinically relevant bloodstream forms of T. brucei gambiense, T. brucei rhodesiense and T. brucei brucei...
March 12, 2018: International Journal for Parasitology, Drugs and Drug Resistance
https://www.readbyqxmd.com/read/29648815/peptidomimetic-based-multi-domain-targeting-offers-critical-evaluation-of-a%C3%AE-structure-and-toxic-function
#19
Sunil Kumar, Anja Henning, Mazin Magzoub, Andrew D Hamilton
The processes associated with the conversion of amyloid beta (Aβ) into intractable amyloid fibers are considered to be pivotal events in Alzheimer's disease (AD). The prevailing hypothesis stipulates that the pre-amyloid oligomers of Aβ are the main culprits associated with the onset and progression of AD, which has prompted efforts to search for therapeutic agents with the ability to inhibit Aβ oligomerization and amyloidogenesis. However, the lack of clinical progress is impeded by the limited structural information about the neurotoxic oligomers...
April 12, 2018: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/29648789/copper-catalyzed-oxidative-carbon-carbon-and-or-carbon-heteroatom-bond-formation-with-o-2-or-internal-oxidants
#20
Xiaodong Tang, Wanqing Wu, Wei Zeng, Huanfeng Jiang
Selective oxidation, a fundamental organic transformation of critical importance, produces value-added products from simple organic molecules. This process is extensively used to incorporate heteroatoms into carbon-based molecules, where high-valent metal salts, hypervalent halogen reagents, and peroxides are widely used as oxidants. Oxidation reactions are extremely challenging because their selectivity is hard to control and/or they form significant quantities of unwanted waste derived from the stoichiometric oxidants...
April 12, 2018: Accounts of Chemical Research
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