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https://www.readbyqxmd.com/read/29322674/exposure-to-west-nile-virus-and-tick-borne-encephalitis-virus-in-dogs-in-spain
#1
I García-Bocanegra, E Jurado-Tarifa, D Cano-Terriza, R Martínez, J E Pérez-Marín, S Lecollinet
In the past decade, the spread of emerging zoonotic flaviviruses (genus Flavivirus, family Flaviviridae) has been reported in many regions worldwide, representing a threat to both human and animal health. A serosurvey was carried out to assess exposure and risk factors associated with antigenically related flaviviruses, particularly West Nile virus (WNV), Usutu virus (USUV) and tick-borne encephalitis virus (TBEV), in dogs in Spain. Flavivirus antibodies were detected in 39 of 815 dogs (4.8%; 95% CI: 3.3-6...
January 11, 2018: Transboundary and Emerging Diseases
https://www.readbyqxmd.com/read/29320512/killing-wolves-to-prevent-predation-on-livestock-may-protect-one-farm-but-harm-neighbors
#2
Francisco J Santiago-Avila, Ari M Cornman, Adrian Treves
Large carnivores, such as gray wolves, Canis lupus, are difficult to protect in mixed-use landscapes because some people perceive them as dangerous and because they sometimes threaten human property and safety. Governments may respond by killing carnivores in an effort to prevent repeated conflicts or threats, although the functional effectiveness of lethal methods has long been questioned. We evaluated two methods of government intervention following independent events of verified wolf predation on domestic animals (depredation) in the Upper Peninsula of Michigan, USA between 1998-2014, at three spatial scales...
2018: PloS One
https://www.readbyqxmd.com/read/29318757/knowledge-gaps-and-research-priorities-in-the-prevention-and-control-of-hepatitis-e-virus-infection
#3
W H M Van der Poel, H R Dalton, R Johne, N Pavio, M Bouwknegt, T Wu, N Cook, X J Meng
Hepatitis E virus (HEV), family Hepeviridae, is a main cause of epidemic hepatitis in developing countries and sporadic and cluster cases of hepatitis in industrialized countries. There are an increasing number of reported cases in humans especially in industrialized countries, and there is a high potential for transboundary spread of zoonotic genotypes of the virus through the transport of pigs, pig products and by-products. Bloodborne transmission of the virus has been reported with a significant medical concern...
January 10, 2018: Transboundary and Emerging Diseases
https://www.readbyqxmd.com/read/29313868/pets-as-potential-carriers-of-multidrug-resistant-enterococcus-faecium-of-significance-to-public-health
#4
Giorgia Dotto, Michele Berlanda, Daniela Pasotto, Alessandra Mondin, Giorgio Zambotto, Maria Luisa Menandro
Enterococci are important opportunistic pathogens for humans and animals and have recently become one of the leading causes of nosocomial infections, raising concerns about their virulence and antimicrobial traits. This study describes a multidrug-resistant Enterococcus faecium isolated from a case of feline urinary tract infection. This strain was characterized for virulence and antimicrobial resistance markers, phylogenetic group and sensitivity to antimicrobial agents used routinely in veterinary and human practice...
January 9, 2018: New Microbiologica
https://www.readbyqxmd.com/read/29306340/review-nutritional-ecology-of-heavy-metals
#5
M Hejna, D Gottardo, A Baldi, V Dell'Orto, F Cheli, M Zaninelli, L Rossi
The aim of this review is to focus the attention on the nutrition ecology of the heavy metals and on the major criticisms related to the heavy metals content in animal feeds, manure, soil and animal-origin products. Heavy metals are metallic elements that have a high density that have progressively accumulated in the food chain with negative effects for human health. Some metals are essential (Fe, I, Co, Zn, Cu, Mn, Mo, Se) to maintain various physiological functions and are usually added as nutritional additives in animal feed...
January 8, 2018: Animal: An International Journal of Animal Bioscience
https://www.readbyqxmd.com/read/29299685/toxoplasma-gondii-infection-and-biosecurity-levels-in-fattening-pigs-and-sows-serological-and-molecular-epidemiology-in-the-intensive-pig-industry-lombardy-northern-italy
#6
Alessia Libera Gazzonis, Marianna Marangi, Luca Villa, Maria Elena Ragona, Emanuela Olivieri, Sergio Aurelio Zanzani, Annunziata Giangaspero, Maria Teresa Manfredi
Toxoplasma gondii is a widespread protozoan affecting animals and humans. One of the major routes of human infection is through the consumption of raw or under-cooked meat, particularly of certain animal species, including pigs. Although T. gondii represents an important public health issue, its control at slaughter is not mandatory. Consequently, available information on T. gondii infection in domestic animals destined for human consumption is scarce. Thus, an epidemiologic survey was designed to update information on T...
January 3, 2018: Parasitology Research
https://www.readbyqxmd.com/read/29298883/cell-to-cell-measles-virus-spread-between-human-neurons-dependent-on-the-hemagglutinin-and-the-hyperfusogenic-fusion-protein
#7
Yuma Sato, Shumpei Watanabe, Yoshinari Fukuda, Takao Hashiguchi, Yusuke Yanagi, Shinji Ohno
Measles virus (MV) usually causes acute infection, but in rare cases persists in the brain, resulting in subacute sclerosing panencephalitis (SSPE). Since human neurons, an important target affected in the disease, do not express the known MV receptors (signaling lymphocyte activation molecule (SLAM) and nectin 4), how MV infects neurons and spreads between them is unknown. Recent studies have shown that many virus strains isolated from SSPE patients possess substitutions in the extracellular domain of the fusion (F) protein which confer enhanced fusion activity...
January 3, 2018: Journal of Virology
https://www.readbyqxmd.com/read/29284246/changes-in-leptospirosis-etiology-in-animals-and-humans
#8
Natalia Vasylieva, Mykhaylo Andreychyn, Yulia Kravchuk, Оlena Chervinska, Iaryna Iosyk
INTRODUCTION: Leptospirosis is endemic in Ternopil region. In Ukraine, the disease is registered in almost all regions, including the Ternopil region. The aim of the research is to study the regularities of epidemic and epizootic processes of leptospirosis, and the circulation of its pathogens among different sources (small mammals, animals) and humans. MATERIAL AND METHODS: Etiologic spectrum of leptospirosis registered in Ternopil region in 1972-2016 among small mammals, farm animals and sick people was studied...
December 23, 2017: Annals of Agricultural and Environmental Medicine: AAEM
https://www.readbyqxmd.com/read/29279280/the-path-towards-effective-antivirals-against-rabies
#9
Dirk Jochmans, Johan Neyts
Rabies virus remains an important burden of disease claiming an estimated 60,000 lives each year, mainly children, and having a huge economical and societal cost. Post-exposure prophylaxis (PEP) is highly effective, however in patients that present with neurological symptoms the case-fatality ratio is extremely high (>99%). During the last decades several attempts to identify potent and effective antivirals were made. Only a few of these demonstrated improvement in clinical signs in animal studies and none of the trials in humans showed significant efficacy...
December 23, 2017: Vaccine
https://www.readbyqxmd.com/read/29277728/draft-genome-sequence-of-an-extensively-drug-resistant-xdr-pseudomonas-aeruginosa-belonging-to-st644-isolated-from-a-footpad-infection-in-a-magellanic-penguin-spheniscus-magellanicus
#10
Fábio P Sellera, Miriam R Fernandes, Quézia Moura, Tiago A Souza, Cristiane L Nascimento, Louise Cerdeira, Nilton Lincopan
OBJECTIVES: The incidence of multidrug-resistant (MDR) bacteria in wildlife animals has been investigated in order to improve the knowledge on the spreading of clinically relevant antimicrobial resistance genes. The aim of this study was to report the first draft genome sequence of an extensively drug-resistant (XDR) Pseudomonas aeruginosa ST644 recovered from a Magellanic penguin with footpad infection undergoing rehabilitation process. METHODS: Genome was sequenced on Illumina NextSeq platform, using paired-end reads (150bp)...
December 22, 2017: Journal of Global Antimicrobial Resistance
https://www.readbyqxmd.com/read/29277623/molecular-mechanistic-pathway-of-colorectal-carcinogenesis-associated-with-intestinal-microbiota
#11
REVIEW
Paramita Mandal
The colon rectal portion of gastrointestinal tract (GI) is full of microorganisms with different complex community that plays important role in maintaining homeostasis. But now-a-days different literature indicated that microbiota cause development of colorectal cancer (CRC) with a disease and ultimately aggravates to death. The mechanism inside the colo-rectal portion of GI tract is not fully well-known and bacterial contribution inside it is also fully unclear. Therefore, there is certain evidence trying a target about the unclear mechanism between intestinal microbiota and CRC...
December 19, 2017: Anaerobe
https://www.readbyqxmd.com/read/29276617/antimicrobial-resistance-in-human-populations-challenges-and-opportunities
#12
REVIEW
S Allcock, E H Young, M Holmes, D Gurdasani, G Dougan, M S Sandhu, L Solomon, M E Török
Antimicrobial resistance (AMR) is a global public health threat. Emergence of AMR occurs naturally, but can also be selected for by antimicrobial exposure in clinical and veterinary medicine. Despite growing worldwide attention to AMR, there are substantial limitations in our understanding of the burden, distribution and determinants of AMR at the population level. We highlight the importance of population-based approaches to assess the association between antimicrobial use and AMR in humans and animals. Such approaches are needed to improve our understanding of the development and spread of AMR in order to inform strategies for the prevention, detection and management of AMR, and to support the sustainable use of antimicrobials in healthcare...
2017: Glob Health Epidemiol Genom
https://www.readbyqxmd.com/read/29275873/current-and-potential-future-distribution-of-the-american-dog-tick-dermacentor-variabilis-say-in-north-america
#13
Jordan N Minigan, Heather A Hager, Andrew S Peregrine, Jonathan A Newman
The American dog tick (Dermacentor variabilis) is medically and economically important in North America. This species is found across central and eastern North America from the Gulf Coast of Mexico through southern Canada. In parts of this region, D. variabilis is a vector for pathogens that cause diseases in humans and animals. Our aim was to determine whether climate change would affect the distribution of the climatically suitable area for D. variabilis in North America, to aid monitoring for potential future spread of tick-borne pathogens...
December 8, 2017: Ticks and Tick-borne Diseases
https://www.readbyqxmd.com/read/29260917/how-have-our-clocks-evolved-adaptive-and-demographic-history-of-the-out-of-african-dispersal-told-by-polymorphic-loci-in-circadian-genes
#14
Arcady A Putilov, Vladimir B Dorokhov, Michael G Poluektov
The mechanism of the molecular circadian clocks is currently understood as a transcription/translation feedback loop involving more than ten genes. Genetic variation at some of loci in these genes has been shaped by adaptation to environmental factors. In particular, latitudinal clines in allele frequency were documented in several animal species, but the contradictory conclusions were drawn from the results of rare human studies. Here we tested whether the out-of-African dispersal of human populations to higher latitudes of the Eurasian continent was associated with latitude-dependent shifts in allele frequency at polymorphic loci in genes of three (reference, circadian and skin pigmentation) groups...
December 20, 2017: Chronobiology International
https://www.readbyqxmd.com/read/29260903/antibiotic-resistance-profiling-analysis-of-virulence-aspects-and-molecular-genotyping-of-staphylococcus-aureus-isolated-in-sicily-italy
#15
Maria Vitale, Salvatore Gaglio, Paola Galluzzo, Giuseppe Cascone, Chiara Piraino, Vincenzo Di Marco Lo Presti, Rosa Alduina
Staphylococcus aureus is the major cause of foodborne diseases worldwide. In this retrospective study, 84 S. aureus strains were characterized. The collection comprises 78 strains isolated during 1998 and 2014 from dairy products and tissue samples from livestock bred for dairy production in Sicily. One isolate was obtained from a pet (dog), one from an exotic animal (a circus elephant), and four human isolates were obtained during a severe food poisoning outbreak that occurred in Sicily in 2015. All the strains were characterized by pulsed-field gel electrophoresis (PFGE), for antibiotic resistance and presence of toxin genes...
December 20, 2017: Foodborne Pathogens and Disease
https://www.readbyqxmd.com/read/29260686/characterization-of-a-feline-influenza-a-h7n2-virus
#16
Masato Hatta, Gongxun Zhong, Yuwei Gao, Noriko Nakajima, Shufang Fan, Shiho Chiba, Kathleen M Deering, Mutsumi Ito, Masaki Imai, Maki Kiso, Sumiho Nakatsu, Tiago J Lopes, Andrew J Thompson, Ryan McBride, David L Suarez, Catherine A Macken, Shigeo Sugita, Gabriele Neumann, Hideki Hasegawa, James C Paulson, Kathy L Toohey-Kurth, Yoshihiro Kawaoka
During December 2016-February 2017, influenza A viruses of the H7N2 subtype infected ≈500 cats in animal shelters in New York, NY, USA, indicating virus transmission among cats. A veterinarian who treated the animals also became infected with feline influenza A(H7N2) virus and experienced respiratory symptoms. To understand the pathogenicity and transmissibility of these feline H7N2 viruses in mammals, we characterized them in vitro and in vivo. Feline H7N2 subtype viruses replicated in the respiratory organs of mice, ferrets, and cats without causing severe lesions...
January 2018: Emerging Infectious Diseases
https://www.readbyqxmd.com/read/29259922/exploring-virulence-determinants-of-filamentous-fungal-pathogens-through-interactions-with-soil-amoebae
#17
REVIEW
Silvia Novohradská, Iuliia Ferling, Falk Hillmann
Infections with filamentous fungi are common to all animals, but attention is rising especially due to the increasing incidence and high mortality rates observed in immunocompromised human individuals. Here, Aspergillus fumigatus and other members of its genus are the leading causative agents. Attributes like their saprophytic life-style in various ecological niches coupled with nutritional flexibility and a broad host range have fostered the hypothesis that environmental predators could have been the actual target for some of their virulence determinants...
2017: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/29246178/discovery-of-the-fourth-mobile-sulfonamide-resistance-gene
#18
Mohammad Razavi, Nachiket P Marathe, Michael R Gillings, Carl-Fredrik Flach, Erik Kristiansson, D G Joakim Larsson
BACKGROUND: Over the past 75 years, human pathogens have acquired antibiotic resistance genes (ARGs), often from environmental bacteria. Integrons play a major role in the acquisition of antibiotic resistance genes. We therefore hypothesized that focused exploration of integron gene cassettes from microbial communities could be an efficient way to find novel mobile resistance genes. DNA from polluted Indian river sediments were amplified using three sets of primers targeting class 1 integrons and sequenced by long- and short-read technologies to maintain both accuracy and context...
December 15, 2017: Microbiome
https://www.readbyqxmd.com/read/29240021/differences-in-seizure-expression-between-magnetic-seizure-therapy-and-electroconvulsive-shock
#19
Yael M Cycowicz, Stefan B Rowny, Bruce Luber, Sarah H Lisanby
OBJECTIVE: Evidence suggests that magnetic seizure therapy (MST) results in fewer side effects than electroconvulsive treatment, both in humans treated with electroconvulsive therapy (ECT) as well as in the animal preclinical model that uses electroconvulsive shock (ECS). Evidence suggests that MST results in fewer cognitive side effects than ECT. Although MST offers enhanced control over seizure induction and spread, little is known about how MST and ECT seizures differ. Seizure characteristics are associated with treatment effect...
December 12, 2017: Journal of ECT
https://www.readbyqxmd.com/read/29239715/mitigating-the-risk-of-zika-virus-contamination-of-raw-materials-and-cell-lines-in-the-manufacture-of-biologicals
#20
Joanna Zmurko, Douglas B Vasey, Claire L Donald, Alison A Armstrong, Marian L McKee, Alain Kohl, Reginald F Clayton
Ensuring the virological safety of biologicals is challenging due to the risk of viral contamination of raw materials and cell banks, and exposure during in-process handling to known and/or emerging viral pathogens. Viruses may contaminate raw materials and biologicals intended for human or veterinary use and remain undetected until appropriate testing measures are employed. The outbreak and expansive spread of the mosquito-borne flavivirus Zika virus (ZIKV) poses challenges to screening human- and animal -derived products used in the manufacture of biologicals...
December 14, 2017: Journal of General Virology
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