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Undiagnosed skin lesions

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https://www.readbyqxmd.com/read/28539982/misuse-of-topical-corticosteroids-on-facial-skin-a-study-of-200-patients
#1
Rohini Sharma, Sameer Abrol, Mashqoor Wani
BACKGROUND: Topical corticosteroids have become available as over the counter drugs and are widely misused for various conditions. OBJECTIVE: The aim of this study is to assess the clinical and epidemiological aspects of the unjustified use of topical corticosteroids for facial skin. METHODS: A total of 200 patients with facial dermatoses and topical corticosteroid misapplication daily over face for not less than 30 days were included in the study...
March 31, 2017: Journal of Dermatological Case Reports
https://www.readbyqxmd.com/read/28472571/optimising-cryosurgery-technique
#2
William C Cranwell, Rodney Sinclair
BACKGROUND: Cryosurgery is an effective, simple and inexpensive treatment used extensively in general practice and dermatology. It is used most commonly for actinic keratoses and warts; however, a large number of benign, premalignant and malignant skin diseases can also be treated. OBJECTIVE: The objective of this article is to help readers improve their cryosurgery technique. DISCUSSION: Application of the cryogenic agent (most commonly liquid nitrogen) to the skin induces rapid freezing followed by slow thawing...
2017: Australian Family Physician
https://www.readbyqxmd.com/read/28414661/delayed-presentation-of-tuberour-sclerosis-complex-in-adult-women
#3
J Manalac, S Sadd, G Akoghlanian, T Benoit-Clark
INTRODUCTION: Tuberous sclerosis complex (TSC); is an autosomal dominant disorder characterized by the formation of hamartomatous lesions in multiple organs, with a birth incidence of around one in 10,000. Although it usually manifests itself in early life, we present a case of an adult woman who we diagnosed with TSC. CASE: A 27 year old woman presented to Emergency Department with worsening right flank pain and progressive dyspnea. Physical examination findings revealed Shagreen patches and multiple angiomyolipomas of the skin...
March 2017: Journal of the Louisiana State Medical Society: Official Organ of the Louisiana State Medical Society
https://www.readbyqxmd.com/read/28248822/mucous-membrane-pemphigoid-causing-central-airway-obstruction
#4
Bilal A Jalil, Yara G Abdou, Stephanie A Rosen, Tarek Dammad
Mucous membrane pemphigoid (MMP) is a rare variant of the skin disease pemphigoid, which predominantly involves the mucous membranes. This rare autoimmune disease that infrequently affects the respiratory tract is characterized by subepithelial blister formation that may result in scarring. Immunopathologic examination of mucous membranes reveals the deposition of immunoglobulins and complement within the subepithelial basement membrane. We describe a patient with undiagnosed MMP, with a near-fatal presentation of central airway obstruction causing acute respiratory distress...
February 28, 2017: Journal of Bronchology & Interventional Pulmonology
https://www.readbyqxmd.com/read/28202826/-hypogeusia-and-high-signals-in-the-nuclei-of-the-solitary-tract-on-mri-due-to-varicella-zoster-virus-infection-a-case-report
#5
Yuji Shiga, Yuhei Kanaya, Shinichi Takeshima, Yutaka Shimoe, Akio Tanaka, Masaru Kuriyama
A 63-year-old man noticed hypogeusia after presenting hiccups for several days. He was serologically diagnosed with varicella-zoster virus (VZV) infection, but had no skin lesions typical of herpes (zoster sine herpete). Hypogeusia was confirmed by electrogustometry and the filter-paper disk method, which showed damage in the areas innervated by the cord of tympanum, glossopharyngeal nerve, and greater petrosal nerve. High signals in the nuclei of the solitary tract of the medulla oblongata and the enhancement of the bilateral intracranial segments of the cranial nerve IX and X complex were observed by magnetic resonance imaging (MRI)...
February 2017: Brain and Nerve, Shinkei Kenkyū No Shinpo
https://www.readbyqxmd.com/read/28002821/cutaneous-metastasis-a-study-of-138-cases-diagnosed-by-fine-needle-aspiration-cytology
#6
Uma Handa, Reetu Kundu, Kislay Dimri
BACKGROUND: Cutaneous metastases can occur in a wide variety of internal malignancies and may be the first sign of a clinically silent visceral cancer. STUDY DESIGN: A retrospective analysis was made of 138 cases diagnosed with cutaneous and subcutaneous metastasis on fine-needle aspiration cytology (FNAC). Primary tumors of the skin/subcutis were excluded. RESULTS: Of 138 cases, the primary was known in 101 cases and unknown in 37 cases. The age of the patients ranged from 5 to 86 years, and 76 (55...
2017: Acta Cytologica
https://www.readbyqxmd.com/read/27679535/predominant-corticospinal-tract-involvement-in-a-late-infant-with-krabbe-disease
#7
Ayumi Yoshimura, Tetsuya Kibe, Kaori Irahara, Norio Sakai, Kenji Yokochi
A case of late-infantile Krabbe disease in a patient who presented with developmental regression and spastic quadriplegia in late infancy is reported. Brain magnetic resonance imaging (MRI) at 11 months of age showed predominant corticospinal tract involvement, which usually appears in adult Krabbe disease. Galactocerebrosidase activity in lymphocytes and skin fibroblasts was very low. Genetic testing revealed compound heterozygous mutations of the galactocerebrosidase (GALC) gene, c.635_646 delinsCTC and c...
2016: Japanese Clinical Medicine
https://www.readbyqxmd.com/read/26877232/extensive-tumoral-melanosis-associated-with-ipilimumab-treated-melanoma
#8
K Staser, D Chen, J Solus, I S Rosman, A Schaffer, L Cornelius, G P Linette, R C Fields
Tumoral melanosis describes a pigmented lesion clinically similar to melanoma but on histology reveals dense aggregates of melanin-laden, benign macrophages without malignant cells. In the few reported cases so far, tumoral melanosis has arisen in the skin or lymph node of a patient with a regressed melanoma or an epithelioid tumour. As a marker of regressed primary melanoma, its discovery may prompt investigation and surveillance for undiagnosed local or metastatic disease. Here, we present a unique case of extensive tumoral melanosis arising during ipilimumab treatment of in-transit metastases from a previously excised melanoma...
August 2016: British Journal of Dermatology
https://www.readbyqxmd.com/read/26597583/-dynamic-concept-of-oral-lichen-planus-the-diagnosis-easy-at-early-stages-may-become-difficult-in-ancient-lichen-planus
#9
Tommaso Lombardi, Roger Küffer
Dynamic concept of oral lichen planus. The diagnosis easy at early stages may become difficult in ancient lichen planus. Lichen planus is a chronic inflammatory dermatosis of the skin, skin appendages and mucous membranes, which frequently affects the oral mucosa. Its aetiology still remains unknown, and currently accepted pathogenesis is that of an autoimmune cell-mediated disease. To the contrary of skin lichen planus, oral lichen planus is a long-term chronic disease with dynamic evolution, in which progressive and profound changes of the clinical and histopathological aspects occur over time and under the influence of various exogenous factors...
February 2016: La Presse Médicale
https://www.readbyqxmd.com/read/26566619/lucio-s-phenomenon-an-uncommon-occurrence-among-leprosy-patients-in-sri-lanka
#10
Sandamalee Herath, Mitrakrishnan Rayno Navinan, Isurujith Liyanage, Nadeesha Rathnayaka, Jevon Yudhishdran, Janakie Fernando, Ganga Sirimanne, Aruna Kulatunga
BACKGROUND: Lucio's phenomenon is a rare manifestation of untreated leprosy which is seen almost exclusively in regions surrounding the Gulf of Mexico. Its occurrence elsewhere though documented is considered uncommon. We present a case of Lucio's phenomenon in a previously undiagnosed leprosy patient who presented to us with its classical skin manifestations. CASE PRESENTATION: A 64 year old South Asian (Sri Lankan) male with a history of chronic obstructive airway disease presented to us with fever and cough...
2015: BMC Research Notes
https://www.readbyqxmd.com/read/26485704/pkdl-a-silent-parasite-pool-for-transmission-of-leishmaniasis-in-kala-azar-endemic-areas-of-malda-district-west-bengal-india
#11
Swagata Ganguly, Pabitra Saha, Moytrey Chatterjee, Surajit Roy, Tamal Kanti Ghosh, Subhasish K Guha, Pratip K Kundu, Dilip K Bera, Nandita Basu, Ardhendu K Maji
Post Kala-azar Dermal Leishmaniasis (PKDL) is a chronic but not life-threatening disease; patients generally do not demand treatment, deserve much more attention because PKDL is highly relevant in the context of Visceral Leishmaniasis (VL) elimination. There is no standard guideline for diagnosis and treatment for PKDL. A species-specific PCR on slit skin smear demonstrated a sensitivity of 93.8%, but it has not been applied for routine diagnostic purpose. The study was conducted to determine the actual disease burden in an endemic area of Malda district, West Bengal, comparison of the three diagnostic tools for PKDL case detection and pattern of lesion regression after treatment...
2015: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/26217401/an-assessment-of-the-cost-effectiveness-safety-of-referral-and-patient-satisfaction-of-a-general-practice-teledermatology-service
#12
Judith Livingstone, Jessica Solomon
BACKGROUND: In the cost-constrained NHS and in the quest for rapid diagnosis, teledermatology is a tool that can be used within general practice to aid in the diagnosis of benign-looking skin lesions and reduce referrals to secondary care. The setting for the study was a single general practice of 6500 patients in suburban Greater London. The aim of the study was to determine: (1) whether teledermatology in a single general practice is cost-effective, (2) whether the correct types of cases are being referred, and (3) if patients are satisfied with the service...
2015: London Journal of Primary Care
https://www.readbyqxmd.com/read/26165579/prolonged-exposure-dermatosis-reporting-high-incidence-of-an-undiagnosed-facial-dermatosis-on-a-winter-wilderness-expedition
#13
Jodie E Totten, Douglas M Brock, Tod D Schimelpfenig, Justin L Hopkin, Roy M Colven
OBJECTIVE: Previously unclassified inflammatory skin lesions referred to as sun bumps have been observed throughout the year on participants of wilderness trips; however, the underlying cause and diagnosis remain unclear. The purpose of this prospective observational study was to document the incidence, characteristics, and risk factors associated with these skin lesions as they occurred on a winter wilderness expedition. METHODS: For this study, the lesions were defined as pruritic or erythematous skin lesions occurring while in the wilderness...
December 2015: Wilderness & Environmental Medicine
https://www.readbyqxmd.com/read/26026773/nail-psoriasis-as-a-predictor-of-the-development-of-psoriatic-arthritis
#14
REVIEW
I Raposo, T Torres
Psoriatic arthritis is a psoriasis-related spondyloarthropathy that occurs in 20-30% of patients with psoriasis. Various imaging studies have demonstrated that there is a considerable proportion of undiagnosed psoriatic arthritis among patients with psoriasis. Since early detection and treatment of psoriatic arthritis could, ultimately, allow the prevention of clinical and radiologic progression of the disease, there is the need to establish clinical indicators to detect this risk. Nail psoriasis has been proposed as a predictor for the development of psoriatic arthritis...
July 2015: Actas Dermo-sifiliográficas
https://www.readbyqxmd.com/read/25939124/chronic-iritis-associated-with-cutaneous-leukocytoclastic-vasculitis
#15
Jessica Lambert, Alexis Rodriguez, Mischelle Pearcy-Baluyot, Sanjeet K Shahi
Cutaneous leukocytoclastic vasculitis (LCV) is a systemic condition that can be associated with iritis. LCV is characterized as a small-vessel vasculitis of the cutaneous area. The disease demonstrates purple lesions on the skin due to the destruction of small cutaneous blood vessels. These lesions are palpable and most often coalesce forming larger patches on the surface of the skin. During early stages of LCV, the disease can be undetected due to the infrequency and small size of the skin lesions. As such, the patient might go undiagnosed for years while having symptoms of LCV or iritis of unknown etiology...
May 2015: Military Medicine
https://www.readbyqxmd.com/read/25675656/erythema-nodosum-leprosum-mimicking-sweet-s-syndrome-an-uncommon-presentation
#16
Vikram K Mahajan, C Abhinav, Karaninder S Mehta, Pushpinder S Chauhan
Erythema nodosum leprosum (ENL) lesions may uncommonly develop ulceration, necrosis, pustulation or bullae. This 60 year-old female was hospitalised with previously undiagnosed multibacillary (BL) leprosy and Sweet's syndrome-like ENL, a presentation that is rarely reported. In addition to skin lesions simulating Sweet's syndrome, she had anaemia, elevated ESR, and a peripheral leucocytosis with neutrophilia, the laboratory features of Sweet's syndrome. The final diagnosis was made from chronic iridocyclitis, presence of lepra bacilli in slit-skin smears, and histology...
December 2014: Leprosy Review
https://www.readbyqxmd.com/read/25557739/necrotizing-and-sarcoidal-granulomas-in-the-skin-and-synovial-membrane-associated-with-common-variable-immunodeficiency
#17
A Plana Pla, J Bassas-Vila, S Roure, C Ferrándiz
Common variable immunodeficiency (CVID) is a primary immunodeficiency characterized by hypogammaglobulinaemia, T-cell abnormalities and recurrent bacterial infections. Patients with CVID can present granulomatous lesions on both the skin and other organs. When these lesions are the first sign of the disease, the diagnosis can be very challenging. We report the case of a patient with undiagnosed CVID, who presented with necrotizing and sarcoidal granulomas on the skin and synovial membrane as the first appearance of immunodeficiency...
June 2015: Clinical and Experimental Dermatology
https://www.readbyqxmd.com/read/25497664/-oral-ulcer-as-primary-manifestation-of-hiv-infection-in-an-80-year-old-man
#18
Lene Ugilt Pagter Ludvigsen, Ole Schmeltz Søgaard
Oral lesions such as candidiasis, Kaposi's sarcoma, hairy leukoplakia, herpes simplex infection, and ulcerative periodontitis are associated with HIV infection and may be the primary presentation in persons with undiagnosed HIV. We report a clinical case in which an 80-year-old man presented with an oral ulcer with morphological signs of immuno-suppression. The patient was perceived to be at low risk of HIV infection and thus, diagnostic HIV testing was delayed until subsequent development of Kaposi's sarcoma on the skin...
December 15, 2014: Ugeskrift for Laeger
https://www.readbyqxmd.com/read/25337682/when-less-is-more-primary-immunodeficiency-with-an-autoinflammatory-kick
#19
REVIEW
Angeliki Giannelou, Qing Zhou, Daniel L Kastner
PURPOSE OF REVIEW: Next-generation sequencing is revolutionizing the molecular taxonomy of human disease. Recent studies of patients with unexplained autoinflammatory disorders reveal germline genetic mutations that target important regulators of innate immunity. RECENT FINDINGS: Whole-exome analyses of previously undiagnosed patients have catalyzed the recognition of two new disease genes. First, a phenotypic spectrum, including livedo racemosa, fever with early-onset stroke, polyarteritis nodosa, and Sneddon syndrome, is caused by loss-of-function mutations in cat eye syndrome chromosome region, candidate 1 (CECR1), encoding adenosine deaminase 2...
December 2014: Current Opinion in Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/25296605/small-bowel-perforation-caused-by-advanced-melanoma
#20
Sjoerd H den Uil, Irene Thomassen, Erik Gj Vermeulen, Ronald Jclm Vuylsteke, Hein Bac Stockmann, Mattijs de Vries
The incidence of melanoma has been increasing over the years and it remains, despite the heterogeneous survival for different stages, a disease with high mortality. Dissemination occurs primarily by the lymphatic route, followed by the hematogenous route. Gastrointestinal metastases do occur, but they are mainly intraluminal mucosal melanomas. Peritoneal or primary mucosal melanomas are rare. Only a few cases have been described of patients presenting with acute abdominal pain due to a melanoma. In this report we present a young patient with no prior health problems...
July 2014: Tumori
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