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Mad cow disease

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https://www.readbyqxmd.com/read/27894411/allele-specific-pcr-and-melting-curve-analysis-showed-relatively-high-frequency-of-%C3%AE-casein-gene-a1-allele-in-iranian-holstein-simmental-and-native-cows
#1
M Gholami, S H Hafezian, G Rahimi, A Farhadi, Z Rahimi, D Kahrizi, S Kiani, H Karim, S Vaziri, S Muhammadi, F Veisi, K Ghadiri, H Shetabi, J Zargooshi
There are two allelic forms of A1 and A2 of β-casein gene in dairy cattle. Proteolytic digestion of bovine β-casein A1 type produces bioactive peptide of β-casomorphin-7 known as milk devil. β-casomorphin-7 causes many diseases, including type 1 diabetes, cardiovascular disease syndrome, sudden death and madness. The aim of the present study was to determine the different allelic forms of β-casein gene in Iranian Holstein, Simmental and native cattle in order to identify A1 and A2 variants. The blood samples were collected randomly and DNA was extracted using modified salting out method...
October 31, 2016: Cellular and Molecular Biology
https://www.readbyqxmd.com/read/27723807/cold-water-fish-gelatin-methacryloyl-hydrogel-for-tissue-engineering-application
#2
Hee Jeong Yoon, Su Ryon Shin, Jae Min Cha, Soo-Hong Lee, Jin-Hoi Kim, Jeong Tae Do, Hyuk Song, Hojae Bae
Gelatin methacryloyl (GelMA) is a versatile biomaterial that has been used in various biomedical fields. Thus far, however, GelMA is mostly obtained from mammalian sources, which are associated with a risk of transmission of diseases, such as mad cow disease, as well as certain religious restrictions. In this study, we synthesized GelMA using fish-derived gelatin by a conventional GelMA synthesis method, and evaluated its physical properties and cell responses. The lower melting point of fish gelatin compared to porcine gelatin allowed larger-scale synthesis of GelMA and enabled hydrogel fabrication at room temperature...
2016: PloS One
https://www.readbyqxmd.com/read/27566851/efficient-edition-of-the-bovine-prnp-prion-gene-in-somatic-cells-and-ivf-embryos-using-the-crispr-cas9-system
#3
R J Bevacqua, R Fernandez-Martín, V Savy, N G Canel, M I Gismondi, W A Kues, D F Carlson, S C Fahrenkrug, H Niemann, O A Taboga, S Ferraris, D F Salamone
The recently developed engineered nucleases, such as zinc-finger nucleases, transcription activator-like effector nucleases, and clustered regularly interspaced short palindromic repeat (CRISPR)/CRISPR-associated nuclease (Cas) 9, provide new opportunities for gene editing in a straightforward manner. However, few reports are available regarding CRISPR application and efficiency in cattle. Here, the CRISPR/Cas9 system was used with the aim of inducing knockout and knock-in alleles of the bovine PRNP gene, responsible for mad cow disease, both in bovine fetal fibroblasts and in IVF embryos...
November 2016: Theriogenology
https://www.readbyqxmd.com/read/27518312/atypical-variants-of-bovine-spongiform-encephalopathy-rare-diseases-with-consequences-for-bse-surveillance-and-control
#4
C Boujon, F Serra, T Seuberlich
Occurring for the first time in 1986 in the United Kingdom, bovine spongiform encephalopathy (BSE), the so-called "mad-cow disease", has had unprecedented consequences in veterinary public health. The implementation of drastic measures, including the ban of meat-and-bone-meal from livestock feed and the removal of specified risk materials from the food chain has eventually resulted in a significant decline of the epidemic. The disease was long thought to be caused by a single agent, but since the introduction of immunochemical diagnostic techniques, evidence of a phenotypic variation of BSE has emerged...
March 2016: Schweizer Archiv Für Tierheilkunde
https://www.readbyqxmd.com/read/27477054/a-single-amino-acid-asp159-from-the-dog-prion-protein-suppresses-the-toxicity-of-the-mouse-prion-protein-in-drosophila
#5
J Sanchez-Garcia, K Jensen, Y Zhang, D E Rincon-Limas, P Fernandez-Funez
Misfolding of the prion protein (PrP) is the key step in the transmission of spongiform pathologies in humans and several animals. Although PrP is highly conserved in mammals, a few changes in the sequence of endogenous PrP are proposed to confer protection to dogs, which were highly exposed to prion during the mad-cow epidemics. D159 is a unique amino acid found in PrP from dogs and other canines that was shown to alter surface charge, but its functional relevance has never been tested in vivo. Here, we show in transgenic Drosophila that introducing the N159D substitution on mouse PrP decreases its turnover...
November 2016: Neurobiology of Disease
https://www.readbyqxmd.com/read/27364252/human-prion-diseases-surgical-lessons-learned-from-iatrogenic-prion-transmission
#6
David J Bonda, Sunil Manjila, Prachi Mehndiratta, Fahd Khan, Benjamin R Miller, Kaine Onwuzulike, Gianfranco Puoti, Mark L Cohen, Lawrence B Schonberger, Ignazio Cali
The human prion diseases, or transmissible spongiform encephalopathies, have captivated our imaginations since their discovery in the Fore linguistic group in Papua New Guinea in the 1950s. The mysterious and poorly understood "infectious protein" has become somewhat of a household name in many regions across the globe. From bovine spongiform encephalopathy (BSE), commonly identified as mad cow disease, to endocannibalism, media outlets have capitalized on these devastatingly fatal neurological conditions. Interestingly, since their discovery, there have been more than 492 incidents of iatrogenic transmission of prion diseases, largely resulting from prion-contaminated growth hormone and dura mater grafts...
July 2016: Neurosurgical Focus
https://www.readbyqxmd.com/read/26991940/correction-cannibalism-kuru-and-mad-cows-prion-disease-as-a-choose-your-own-experiment-case-study-to-simulate-scientific-inquiry-in-large-lectures
#7
(no author information available yet)
No abstract text is available yet for this article.
March 2016: PLoS Biology
https://www.readbyqxmd.com/read/26788803/cannibalism-kuru-and-mad-cows-prion-disease-as-a-choose-your-own-experiment-case-study-to-simulate-scientific-inquiry-in-large-lectures
#8
Antonio Serrano, Jeffrey Liebner, Justin K Hines
Despite significant efforts to reform undergraduate science education, students often perform worse on assessments of perceptions of science after introductory courses, demonstrating a need for new educational interventions to reverse this trend. To address this need, we created An Inexplicable Disease, an engaging, active-learning case study that is unusual because it aims to simulate scientific inquiry by allowing students to iteratively investigate the Kuru epidemic of 1957 in a choose-your-own-experiment format in large lectures...
January 2016: PLoS Biology
https://www.readbyqxmd.com/read/26424281/prion-specific-antibodies-produced-in-wild-type-mice
#9
Peter M H Heegaard, Ann-Louise Bergström, Heidi Gertz Andersen, Henriette Cordes
Peptide-specific antibodies produced against synthetic peptides are of high value in probing protein structure and function, especially when working with challenging proteins, including not readily available, non-immunogenic, toxic, and/or pathogenic proteins. Here, we present a straightforward method for production of mouse monoclonal antibodies (MAbs) against peptides representing two sites of interest in the bovine prion protein (boPrP), the causative agent of bovine spongiform encephalopathy ("mad cow disease") and new variant Creutzfeldt-Jakob's disease (CJD) in humans, as well as a thorough characterization of their reactivity with a range of normal and pathogenic (misfolded) prion proteins...
2015: Methods in Molecular Biology
https://www.readbyqxmd.com/read/26357946/the-canadian-management-of-bovine-spongiform-encephalopathy-in-historical-and-scientific-perspective-1990-2014
#10
REVIEW
Alexandra E Quimby, Michel C F Shamy
On February 11, 2015, the Canadian Food Inspection Agency announced that a cow born and raised in Alberta had tested positive for bovine spongiform encephalopathy (BSE), commonly known as mad cow disease. BSE is a prion disease of cattle that, when transmitted to humans, produces a fatal neurodegenerative disease known as variant Creutzfeldt-Jakob disease. We believe that this latest case of BSE in Canadian cattle suggests the timeliness of a review of the management of BSE in Canada from a historically and scientifically informed perspective...
November 2015: Canadian Journal of Neurological Sciences. le Journal Canadien des Sciences Neurologiques
https://www.readbyqxmd.com/read/26194929/uk-government-s-handling-of-mad-cow-disease
#11
Colin Martin
No abstract text is available yet for this article.
August 2015: Lancet Neurology
https://www.readbyqxmd.com/read/26172875/characterization-of-a-60-kda-thermally-stable-antigenic-protein-as-a-marker-for-the-immunodetection-of-bovine-plasma-derived-food-ingredients
#12
Jack A Ofori, Yun-Hwa P Hsieh
A sandwich enzyme-linked immunosorbent assay (sELISA) based on 2 monoclonal antibodies (Bb3D6 and Bb6G12) that recognize a 60-kDa antigenic protein in bovine blood was previously developed for detecting bovine blood in animal feed for the prevention of mad cow disease. This study sought to establish the identity of this 60-kDa antigenic protein and consequently determine the suitability of the sELISA for detecting bovine plasma-derived food ingredients (BPFIs), which are widely used in dietary products without explicit labeling...
August 2015: Journal of Food Science
https://www.readbyqxmd.com/read/26043781/molecular-dynamics-studies-on-the-buffalo-prion-protein
#13
Jiapu Zhang, Feng Wang, Subhojyoti Chatterjee
It was reported that buffalo is a low susceptibility species resisting to transmissible spongiform encephalopathies (TSEs) (same as rabbits, horses, and dogs). TSEs, also called prion diseases, are invariably fatal and highly infectious neurodegenerative diseases that affect a wide variety of species (except for rabbits, dogs, horses, and buffalo), manifesting as scrapie in sheep and goats; bovine spongiform encephalopathy (BSE or "mad-cow" disease) in cattle; chronic wasting disease in deer and elk; and Creutzfeldt-Jakob diseases, Gerstmann-Sträussler-Scheinker syndrome, fatal familial insomnia, and Kulu in humans etc...
2016: Journal of Biomolecular Structure & Dynamics
https://www.readbyqxmd.com/read/25536833/-mad-cow-disease-and-new-form-of-creutzfeldt-jakob-disease-state-of-the-art
#14
REVIEW
Nau Jewan-Yves
No abstract text is available yet for this article.
November 5, 2014: Revue Médicale Suisse
https://www.readbyqxmd.com/read/25530409/an-alarming-presentation-of-creutzfeldt-jakob-disease-following-a-self-inflicted-gunshot-wound-to-the-head
#15
Carissa Harnish, Brian Gross, Katelyn Rittenhouse, Katherine Bupp, Ashley Vellucci, Jeffrey Anderson, Deborah Riley, Frederick B Rogers
Transmissible spongiform encephalopathies (TSE), also known as prion diseases, are characterized by rapid and fatal neurological decline. They not only detrimentally affect the patient, but also present additional challenges to healthcare systems due to the infectivity of the tissues and the difficulty of inactivating the prion. The most common TSE is Creutzfeldt-Jakob disease (CJD), which can occur after familial, spontaneous or acquired transmission. TSEs received more attention after the development of variant CJD (vCJD), also known as Mad Cow Disease, in the UK during the mid-1990s...
May 2015: Injury
https://www.readbyqxmd.com/read/25416110/the-role-of-chemical-engineering-in-medicinal-research-including-alzheimer-s
#16
REVIEW
Georgios M Kontogeorgis
Various disciplines of chemical engineering, especially thermodynamics and kinetics, play an important role in medicinal research and this has been particularly recognized during the last 10-15 years (von Stockar and van der Wielen, J Biotechnol 59:25, 1997; Prausnitz, Fluid Phase Equilib 53:439, 1989; Prausnitz, Pure Appl Chem 79:1435, 2007; Dey and Prausnitz, Ind Eng Chem Res 50:3, 2011; Prausnitz, J Chem Thermodynamics 35:21, 2003; Tsivintzelis et al. AIChE J 55:756, 2009). It is expected that during the twenty-first century chemical engineering and especially thermodynamics can contribute as significantly to the life sciences development as it has been done with the oil and gas and chemical sectors in the twentieth century...
2015: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/25373387/a-survey-and-a-molecular-dynamics-study-on-the-central-hydrophobic-region-of-prion-proteins
#17
REVIEW
Jiapu Zhang, Feng Wang
Prion diseases which are serious neurodegenerative diseases that affect humans and animals occur in various of species. Unlike many other neurodegenerative diseases affected by amyloid, prion diseases can be highly infectious. Prion diseases occur in many species. In humans, prion diseases include the fatal human neurodegenerative diseases such as Creutzfeldt-Jakob Disease (CJD), Fatal Familial Insomnia (FFI), Gerstmann-Strussler-Scheinker syndrome (GSS) and Kuru etc. In animals, prion diseases are related to the bovine spongiform encephalopathy (BSE or 'mad-cow' disease) in cattle, the chronic wasting disease (CWD) found in deer and elk, and scrapie seen in sheep and goats, etc...
2014: Current Pharmaceutical Biotechnology
https://www.readbyqxmd.com/read/25295992/transoperative-refusion-a-simple-and-safe-method-in-emergency-surgery
#18
Luiz Carlos Buarque Gusmão, Sérgio Henrique Chagas Valoes, José da Silva Leitão Neto
The objective is to reinforce the importance of blood reinfusion as a cheap, safe and simple method, which can be used in small hospitals, especially those in which there is no blood bank. Moreover, even with the use of devices that perform the collection and filtration of blood, more recent studies show that the cost-benefit ratio is much better when autologous transfusion is compared with blood transfusions, even when there is injury to hollow viscera and blood contamination. It is known that the allogeneic blood transfusion carries a number of risks to patients, among them are the coagulation disorders mediated by excess enzymes in the conserved blood, and deficiency in clotting factors, mainly the Factor V, the proacelerin...
July 2014: Revista do Colégio Brasileiro de Cirurgiões
https://www.readbyqxmd.com/read/25081076/isolation-of-low-molecular-weight-heparin-heparan-sulfate-from-marine-sources
#19
REVIEW
Ramachandran Saravanan
The glycosaminoglycan (heparin and heparan sulfate) are polyanionic sulfated polysaccharides mostly recognized for its anticoagulant activity. In many countries, low-molecular-weight heparins have replaced the unfractionated heparin, owing to its high bioavailability, half-life, and less adverse effect. The low-molecular-weight heparins differ in mode of preparation (chemical or enzymatic synthesis and chromatography fractionations) and as a consequence in molecular weight distribution, chemical structure, and pharmacological activities...
2014: Advances in Food and Nutrition Research
https://www.readbyqxmd.com/read/25034259/determination-of-the-ruminant-origin-of-bone-particles-using-fluorescence-in-situ-hybridization-fish
#20
M C Lecrenier, Q Ledoux, G Berben, O Fumière, C Saegerman, V Baeten, P Veys
Molecular biology techniques such as PCR constitute powerful tools for the determination of the taxonomic origin of bones. DNA degradation and contamination by exogenous DNA, however, jeopardise bone identification. Despite the vast array of techniques used to decontaminate bone fragments, the isolation and determination of bone DNA content are still problematic. Within the framework of the eradication of transmissible spongiform encephalopathies (including BSE, commonly known as "mad cow disease"), a fluorescence in situ hybridization (FISH) protocol was developed...
2014: Scientific Reports
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