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https://www.readbyqxmd.com/read/29334374/transitory-presence-of-myeloid-derived-suppressor-cells-in-neonates-is-critical-for-control-of-inflammation
#1
Yu-Mei He, Xing Li, Michela Perego, Yulia Nefedova, Andrew V Kossenkov, Erik A Jensen, Valerian Kagan, Yu-Feng Liu, Shu-Yu Fu, Qing-Jian Ye, Yan-Hong Zhou, Lai Wei, Dmitry I Gabrilovich, Jie Zhou
Myeloid-derived suppressor cells (MDSCs) are pathologically activated and relatively immature myeloid cells that have been implicated in the immunological regulation of many pathologic conditions. Phenotypically and morphologically, MDSCs are similar to neutrophils (PMN-MDSCs) and monocytes (M-MDSCs). However, they have potent suppressive activity and distinct gene expression profiles and biochemical characteristics. No or very few MDSCs are observed in steady-state physiological conditions. Therefore, until recently, accumulation of MDSCs was considered a consequence of pathological processes or pregnancy...
January 15, 2018: Nature Medicine
https://www.readbyqxmd.com/read/29334143/childhood-alopecia-areata-data-from-the-national-alopecia-areata-registry
#2
Iris Wohlmuth-Wieser, Joyce S Osei, David Norris, Vera Price, Maria K Hordinsky, Angela Christiano, Madeleine Duvic
BACKGROUND/OBJECTIVES: Alopecia areata may occur at any age and is the third-most-common dermatosis in children. The objective of this study was to investigate the clinical and epidemiologic features of children and adolescents with alopecia areata based on the data of the National Alopecia Areata registry on children and adolescents. METHODS: Two thousand two hundred eighteen children and adolescents with alopecia areata self-enrolled in the National Alopecia Areata Registry and completed a web-based, self-administered, short-intake screening questionnaire (first tier)...
January 15, 2018: Pediatric Dermatology
https://www.readbyqxmd.com/read/29334142/severe-ectropion-in-lamellar-ichthyosis-managed-medically-with-oral-acitretin
#3
Manpreet Singh, Manpreet Kaur, Ripanjeet Kaur, Shakeen Singh
Congenital ectropion is commonly associated with lamellar ichthyosis. Severe eyelid ectropion may cause corneal exposure, keratopathy, and permanent corneal scarring. We report a neonate with severe, bilateral, congenital ectropion and eclabium managed using oral retinoids. Both corneas were protected with topical antibiotics and lubricating eyedrops and eye ointments. At 12-month follow-up, the child was doing well, with no ectropion or corneal opacity.
January 15, 2018: Pediatric Dermatology
https://www.readbyqxmd.com/read/29333864/non-digestible-carbohydrates-in-infant-formula-as-substitution-for-human-milk-oligosaccharide-functions-effects-on-microbiota-and-gut-maturation
#4
Renate Akkerman, Marijke M Faas, Paul de Vos
Human milk (HM) is the golden standard for nutrition of newborn infants. Human milk oligosaccharides (HMOs) are abundantly present in HM and exert multiple beneficial functions, such as support of colonization of the gut microbiota, reduction of pathogenic infections and support of immune development. HMO-composition is during lactation continuously adapted by the mother to accommodate the needs of the neonate. Unfortunately, for many valid reasons not all neonates can be fed with HM and are either totally or partly fed with cow-milk derived infant formulas, which do not contain HMOs...
January 15, 2018: Critical Reviews in Food Science and Nutrition
https://www.readbyqxmd.com/read/29333838/solitary-median-maxillary-central-incisor-holoprosencephaly-and-congenital-nasal-pyriform-aperture-stenosis-in-a-premature-infant-case-report
#5
Ozkan Ilhan, Yeliz Pekcevik, Sinem Akbay, Senem A Ozdemir, Seyma Memur, Berat Kanar, Ozgur Kirbiyik, Esra A Ozer
Solitary median maxillary central incisor syndrome is a rare disorder involving midline abnormalities such as holoprosencephaly, nasal cavity anomalies, cleft palate-lip, hypotelorism, microcephaly, and panhypopituitarism. Congenital nasal pyriform aperture stenosis is a lethal cause of neonatal respiratory distress due to narrowing of the pyriform aperture anteriorly and it can be confused with choanal atresia. In this report, we present a newborn infant with solitary median maxillary central incisor syndrome accompanied by other abnormalities including holoprosencephaly, nasal pyriform aperture stenosis, microcephaly and panhypopituitarism...
February 1, 2018: Archivos Argentinos de Pediatría
https://www.readbyqxmd.com/read/29333827/rectus-sheath-hematoma-in-a-macrosomie-neonate-following-difficult-delivery-case-report
#6
Suzan Gunduz, Semra Kara, Ayşe Aktas, Abdulkadir Eren, Vedat Bakan
Macrosomia is a risk factor for birth injuries and is associated with neonatal morbidity and mortality. Cephalohematoma and clavicular fracture are the most frequent birth injuries. Intraabdominal injuries are uncommon birth injuries. Rectus sheath hematoma (RSH) is an accumulation of blood in the sheath of rectus abdominis muscle. It is associated with trauma, operations and anticoagulant therapy, especially in adults and elders. We present a macrosomic male neonate with difficult vaginal delivery, who had in the physical examination periumblical ecchymose of 1x1 cm and a parietal cephalohametoma of 1x1 cm...
February 1, 2018: Archivos Argentinos de Pediatría
https://www.readbyqxmd.com/read/29333811/neonatal-mortality-and-associated-factors-in-newborn-infants-admitted-to-a-neonatal-care-unit
#7
Juan C Lona Reyes, René O Pérez Ramírez, Leonardo Llamas Ramos, Larissa M Gómez Ruiz, Edith A Benítez Vázquez, Virginia Rodríguez Patino
INTRODUCTION: The increasing survival rate of preterm infants has altered the epidemiology of neonatal diseases; however, neonatal mortality is still the main component of child mortality. The objective of this study was to evaluate neonatal mortality and associated factors in newborn infants admitted to a neonatal care unit. MATERIAL AND METHODS: Prospective cohort study conducted between January 2016 and January 2017 at Hospital Civil de Guadalajara "Dr. Juan I...
February 1, 2018: Archivos Argentinos de Pediatría
https://www.readbyqxmd.com/read/29333726/calcium-current-properties-in-dystrophin-deficient-ventricular-cardiomyocytes-from-aged-mdx-mice
#8
Lena Rubi, Hannes Todt, Helmut Kubista, Xaver Koenig, Karlheinz Hilber
Duchenne muscular dystrophy (DMD), caused by mutations in the gene encoding for the cytoskeletal protein dystrophin, is linked with severe cardiac complications including cardiomyopathy development and cardiac arrhythmias. We and others recently reported that currents through L-type calcium (Ca) channels were significantly increased, and channel inactivation was reduced in dystrophin-deficient ventricular cardiomyocytes derived from the mdx mouse, the most commonly used animal model for human DMD. These gain-of-function Ca channel abnormalities may enhance the risk of Ca-dependent arrhythmias and cellular Ca overload in the dystrophic heart...
January 2018: Physiological Reports
https://www.readbyqxmd.com/read/29333220/outcomes-of-left-ventricular-function-according-to-treatment-response-for-a-patent-ductus-arteriosus-in-preterm-infants
#9
Soo Jung Kang, Young Sun Cho, Seo Jung Hwang, Hyo Jin Kim
Background: To evaluate the outcomes of left ventricular (LV) function according to treatment response for a hemodynamically significant patent ductus arteriosus (hsPDA) in preterm infants. Methods: Echocardiograms of 21 preterm infants born at gestational age < 31 weeks obtained at term-equivalent age were retrospectively studied. Among preterm infants with a hsPDA, 9 underwent ligation after failure of pharmacological closure (ligation group) and 6 experienced successful pharmacological closure (medication group)...
December 2017: Journal of Cardiovascular Ultrasound
https://www.readbyqxmd.com/read/29333033/gastric-teratoma-an-unusual-presentation-and-location
#10
Jayalaxmi S Aihole, M Narendra Babu, Vinay Jadhav, Deepak Javaregowda
The gastric teratoma is a rare tumor that usually presents as an abdominal mass, with or without features of gastric outlet obstruction. We report two cases of gastric teratoma; one - mature in a male neonate and another - ruptured immature gastric teratoma in a female neonate.
October 2017: Indian Journal of Medical and Paediatric Oncology
https://www.readbyqxmd.com/read/29332984/white-matter-fiber-based-analysis-of-t1w-t2w-ratio-map
#11
Haiwei Chen, Francois Budin, Jean Noel, Juan Carlos Prieto, John Gilmore, Jerod Rasmussen, Pathik D Wadhwa, Sonja Entringer, Claudia Buss, Martin Styner
Purpose: To develop, test, evaluate and apply a novel tool for the white matter fiber-based analysis of T1w/T2w ratio maps quantifying myelin content. Background: The cerebral white matter in the human brain develops from a mostly non-myelinated state to a nearly fully mature white matter myelination within the first few years of life. High resolution T1w/T2w ratio maps are believed to be effective in quantitatively estimating myelin content on a voxel-wise basis...
February 2017: Proceedings of SPIE
https://www.readbyqxmd.com/read/29332978/playful-pigs-evidence-of-consistency-and-change-in-play-depending-on-litter-and-developmental-stage
#12
S M Brown, R Peters, I M Nevison, A B Lawrence
Play behaviour in pre-weaned piglets has previously been shown to vary consistently between litters. This study aimed to determine if these pre-weaning litter differences in play behaviour were also consistent in the post-weaning period. Seven litters of commercially bred piglets were raised in a free farrowing system (PigSAFE) and weaned at 28 days post-farrowing (+/-2 days). Post-weaning piglets were maintained in litter groups in the PigSAFE pen. Analyses have been adjusted for sex both within and between litter as the only statistically significant covariate to play behaviour...
January 2018: Applied Animal Behaviour Science
https://www.readbyqxmd.com/read/29332921/early-diastolic-left-ventricular-relaxation-in-normal-neonates-is-influenced-by-ventricular-stiffness-and-longitudinal-systolic-function
#13
Yukako Homma, Yasunobu Hayabuchi, Tomomasa Terada, Miki Inoue, Kazuhiro Mori
Tissue Doppler velocity during early diastole (e') is one of the most feasible and reproducible echocardiographic assessments to reflect active relaxation of the left ventricle. Although several reports have described the mechanisms of temporal diastolic dysfunction in the early neonatal period, factors influencing diastolic function have not been determined. The purpose of this study was to elucidate factors significantly influencing e' in the early neonatal period.A total of 179 consecutive normal neonates underwent echocardiographic studies performed at 0 days and 5-10 days after birth...
January 15, 2018: International Heart Journal
https://www.readbyqxmd.com/read/29332913/early-extubation-in-the-operating-room-after-congenital-open-heart-surgery
#14
Takuma Fukunishi, Norihiko Oka, Takeshi Yoshii, Kensuke Kobayashi, Nobuyuki Inoue, Tetsuya Horai, Tadashi Kitamura, Hirotsugu Okamoto, Kagami Miyaji
Early extubation in the operating room after congenital open-heart surgery is feasible, but extubation in the intensive care unit after the operation remains common practice at many institutions. The purpose of this study was to evaluate retrospectively the adequacy of our early-extubation strategy and exclusion criteria through analysis based on the Risk Adjustment in Congenital Heart Surgery method (RACHS-1).This retrospective analysis included 359 cases requiring cardiopulmonary bypass (male, 195; female, 164; weight > 3...
January 15, 2018: International Heart Journal
https://www.readbyqxmd.com/read/29332782/long-distance-nonstop-neonatal-transport-from-shanghai-china-to-genoa-italy
#15
Carlo Bellini, Simona Serveli, Luigi A, Pietro M, Daniele S, Luca A Ramenghi, Tiziana Cinti, Francesco Campone
The purpose of this article is to describe the long-distance, nonstop intercontinental transport of a severely ill, mechanically ventilated newborn from Shanghai, China, to Genoa, Italy focusing in particular on the clinical and planning difficulties. The aircraft equipment, the assessment and preparation for transport are discussed.
January 2018: Air Medical Journal
https://www.readbyqxmd.com/read/29332775/development-and-testing-of-a-neonatal-intubation-checklist-for-an-air-medical-transport-team
#16
Lisa A Davidson, Richard B Utarnachitt, Andrew Mason, Taylor Sawyer
OBJECTIVE: We developed a Neonatal Intubation Checklist for Airlift Northwest. Our goal was to improve the preparation, technical proficiency, and safety of neonatal intubation without increasing the time required to perform the procedure. METHODS: The Neonatal Intubation Checklist, a "call and response" checklist for neonatal intubation, was developed. Its effectiveness was evaluated during a baseline assessment and 2 practice sessions after a checklist orientation...
January 2018: Air Medical Journal
https://www.readbyqxmd.com/read/29332612/a-colonization-outbreak-of-penicillin-susceptible-meca-positive-staphylococcus-aureus-in-a-neonatal-ward-of-children-s-hospital
#17
Kisei Minami, Runa Terakawa, Masanori Sato, Yasuhiro Shoji, Takehiko Hiroma, Tomohiko Nakamura, Ayaka Horiuchi, Ayaka Otsuka, Noriko Kubota, Eiko Hidaka, Yoshiyuki Kawakami, Meiji Soe Aung, Nobumichi Kobayashi
No abstract text is available yet for this article.
January 15, 2018: Infection Control and Hospital Epidemiology
https://www.readbyqxmd.com/read/29332610/improvements-in-the-conception-rate-milk-composition-and-embryo-quality-of-rabbit-does-after-dietary-enrichment-with-n-3-polyunsaturated-fatty-acids
#18
M Rodríguez, R M García-García, M Arias-Álvarez, P Millán, N Febrel, N Formoso-Rafferty, J López-Tello, P L Lorenzo, P G Rebollar
This work attempts to confirm the effect of an enriched diet with n-3 polyunsaturated fatty acids (PUFA) trying to mitigate the reproductive performances issues such as low conception rate of primiparous rabbits. A total of 127 does were fed ad libitum throughout their two first cycles with two diets with different fat sources: mixed fat in the control and salmon oil in the enriched one, with 3.19 g/100 g (n=63 does) and 28.77 g/100 g (n=64 does) of n-3 of the total fatty acid, respectively. Feed intake was similar between groups (P>0...
January 15, 2018: Animal: An International Journal of Animal Bioscience
https://www.readbyqxmd.com/read/29332252/a-review-of-the-impact-of-pregnancy-and-childbirth-on-pelvic-floor-function-as-assessed-by-objective-measurement-techniques
#19
REVIEW
Hans Van Geelen, Donald Ostergard, Peter Sand
The objective of this narrative review is to study the impact of pregnancy and childbirth on pelvic floor function as assessed by objective measurement techniques with quantitative data carried out during pregnancy and after childbirth. A literature search in MEDLINE and relevant and up-to-date journals from 1960 until April 2017 was performed for articles dealing with the impact of pregnancy and childbirth on pelvic floor function as assessed by objective measurement methods. Only studies describing objective measurement techniques...
January 13, 2018: International Urogynecology Journal
https://www.readbyqxmd.com/read/29332220/perinatal-outcomes-of-unplanned-out-of-hospital-deliveries-a-case-control-study
#20
Yael Pasternak, Eliana Muskin Wintner, Gil Shechter-Maor, Yehonatan Pasternak, Netanella Miller, Tal Biron-Shental
PURPOSE: To compare the pregnancy and perinatal outcomes of unplanned home or car births vs. in-hospital deliveries. METHODS: A retrospective, case-control study of women who underwent unplanned out-of-hospital deliveries vs. in-hospital deliveries from 2004 through 2014. Matching was based on gestational age and parity in a ratio of 2:1. RESULTS: There were no significant differences between the groups regarding demographic criteria, prenatal care and delivery complications...
January 13, 2018: Archives of Gynecology and Obstetrics
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