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https://www.readbyqxmd.com/read/28640815/an-autonomous-metabolic-role-for-spen
#1
Kelsey E Hazegh, Travis Nemkov, Angelo D'Alessandro, John D Diller, Jenifer Monks, James L McManaman, Kenneth L Jones, Kirk C Hansen, Tânia Reis
Preventing obesity requires a precise balance between deposition into and mobilization from fat stores, but regulatory mechanisms are incompletely understood. Drosophila Split ends (Spen) is the founding member of a conserved family of RNA-binding proteins involved in transcriptional regulation and frequently mutated in human cancers. We find that manipulating Spen expression alters larval fat levels in a cell-autonomous manner. Spen-depleted larvae had defects in energy liberation from stores, including starvation sensitivity and major changes in the levels of metabolic enzymes and metabolites, particularly those involved in β-oxidation...
June 22, 2017: PLoS Genetics
https://www.readbyqxmd.com/read/28556180/multiple-coil-k-space-interpolation-enhances-resolution-in-single-shot-spatiotemporal-mri
#2
Gilad Liberman, Eddy Solomon, Michael Lustig, Lucio Frydman
PURPOSE: Spatio-temporal encoding (SPEN) experiments can deliver single-scan MR images without folding complications and with robustness to chemical shift and susceptibility artifacts. Further resolution improvements are shown to arise by relying on multiple receivers, to interpolate the sampled data along the low-bandwidth dimension. The ensuing multiple-sensor interpolation is akin to recently introduced SPEN interleaving procedures, albeit without requiring multiple shots. METHODS: By casting SPEN's spatial rasterization in k-space, it becomes evident that local k-data interpolations enabled by multiple receivers are akin to real-space interleaving of SPEN images...
May 28, 2017: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/28197876/enhancing-pancreatic-mass-with-normal-serum-ca19-9-key-mdct-features-to-characterize-pancreatic-neuroendocrine-tumours-from-its-mimics
#3
Liang Zhu, Hua-Dan Xue, Wei Liu, Xuan Wang, Xin Sui, Qin Wang, Daming Zhang, Ping Li, Zheng-Yu Jin
OBJECTIVES: To determine key MDCT features for characterizing pancreatic neuroendocrine tumours (PNET) from their mimics, which manifest as enhancing pancreatic mass with normal serum CA19-9 level. METHODS: This retrospective study had institutional review board approval and informed consent was waived. Preoperative multiphase MDCT of 74 patients with enhancing pancreatic masses and normal serum CA19-9 levels were included. Surgical pathologies were PNET (n = 42), microcystic serous cystadenomas (m-SCN, n = 12) and solid pseudopapillary epithelial neoplasms (SPEN, n = 20)...
May 2017: La Radiologia Medica
https://www.readbyqxmd.com/read/27993827/frantz-s-tumour-solid-pseudopapillary-epithelial-neoplasm-spen
#4
Orapin Tanapanpanit, Samornmas Kanngurn, Krit Pongpirul
No abstract text is available yet for this article.
December 19, 2016: BMJ Case Reports
https://www.readbyqxmd.com/read/27918010/spatially-encoded-2d-and-3d-diffusion-ordered-nmr-spectroscopy
#5
Ludmilla Guduff, Ilya Kuprov, Carine van Heijenoort, Jean-Nicolas Dumez
We show that the acquisition of 3D diffusion-ordered NMR spectroscopy (DOSY) experiments can be accelerated significantly with the use of spatial encoding (SPEN). The SPEN DOSY approach is discussed, analysed with numerical simulation, and illustrated on a mixture of small molecules.
December 5, 2016: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/27916658/referenceless-one-dimensional-nyquist-ghost-correction-in-multicoil-single-shot-spatiotemporally-encoded-mri
#6
Ying Chen, Yupeng Liao, Lisha Yuan, Hui Liu, Seong Dae Yun, Nadim Joni Shah, Zhong Chen, Jianhui Zhong
Single-shot spatiotemporally encoded (SPEN) MRI is a novel fast imaging method capable of retaining the time efficiency of single-shot echo planar imaging (EPI) but with distortion artifacts significantly reduced. Akin to EPI, the phase inconsistencies between mismatched even and odd echoes also result in the so-called Nyquist ghosts. However, the characteristic of the SPEN signals provides the possibility of obtaining ghost-free images directly from even and odd echoes respectively, without acquiring additional reference scans...
December 2, 2016: Magnetic Resonance Imaging
https://www.readbyqxmd.com/read/27810749/a-high-throughput-computational-system-to-predict-if-environmental-contaminants-can-bind-to-human-nuclear-receptors
#7
Xiaoxiang Wang, Xiaowei Zhang, Pu Xia, Junjiang Zhang, Yuting Wang, Rui Zhang, John P Giesy, Wei Shi, Hongxia Yu
Some pollutants can bind to nuclear receptors (NRs) and modulate their activities. Predicting interactions of NRs with chemicals is required by various jurisdictions because these molecular initiating events can result in adverse, apical outcomes, such as survival, growth or reproduction. The goal of this study was to develop a high-throughput, computational method to predict potential agonists of NRs, especially for contaminants in the environment or to which people or wildlife are expected to be exposed, including both persistent and pseudo-persistent chemicals...
January 15, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/27718460/sculpting-3d-spatial-selectivity-with-pairs-of-2d-pulses-a-comparison-of-methods
#8
Gil Farkash, Jean-Nicolas Dumez, Lucio Frydman
Enhancing the specificity of the spins' excitation can improve the capabilities of magnetic resonance. Exciting voxels with tailored 3D shapes reduces partial volume effects and enhances contrast, particularly in cases where cubic voxels or other simple geometries do not provide an optimal localization. Spatial excitation profiles of arbitrary shapes can be implemented using so-called multidimensional RF pulses, which are often limited in practice to 2D implementations owing to their sensitivity to field inhomogeneities...
September 6, 2016: Journal of Magnetic Resonance
https://www.readbyqxmd.com/read/27591366/variable-density-sampling-and-non-cartesian-super-resolved-reconstruction-for-spatiotemporally-encoded-single-shot-mri
#9
Lin Chen, Jianpan Huang, Ting Zhang, Jing Li, Congbo Cai, Shuhui Cai
Spatiotemporally encoded (SPEN) single-shot MRI is an emerging ultrafast technique, which is capable of spatially selective acquisition and reduced field-of-view imaging. Compared to uniform sampling, variable density sampling has great potential in reducing aliasing artifacts and improving sampling efficiency. In this study, variable density spiral trajectory and non-Cartesian super-resolved (SR) reconstruction method are developed for SPEN MRI. The gradient waveforms design of spiral trajectory is mathematically described as an optimization problem subjected to the limitations of hardware...
August 28, 2016: Journal of Magnetic Resonance
https://www.readbyqxmd.com/read/27513867/crystal-structure-of-the-spoc-domain-of-the-arabidopsis-flowering-regulator-fpa
#10
Yinglu Zhang, Katarzyna Rataj, Gordon G Simpson, Liang Tong
The Arabidopsis protein FPA controls flowering time by regulating the alternative 3'-end processing of the FLOWERING LOCUS (FLC) antisense RNA. FPA belongs to the split ends (SPEN) family of proteins, which contain N-terminal RNA recognition motifs (RRMs) and a SPEN paralog and ortholog C-terminal (SPOC) domain. The SPOC domain is highly conserved among FPA homologs in plants, but the conservation with the domain in other SPEN proteins is much lower. We have determined the crystal structure of Arabidopsis thaliana FPA SPOC domain at 2...
2016: PloS One
https://www.readbyqxmd.com/read/27494029/whole-exome-sequencing-identifies-tsc1-tsc2-biallelic-loss-as-the-primary-and-sufficient-driver-event-for-renal-angiomyolipoma-development
#11
Krinio Giannikou, Izabela A Malinowska, Trevor J Pugh, Rachel Yan, Yuen-Yi Tseng, Coyin Oh, Jaegil Kim, Magdalena E Tyburczy, Yvonne Chekaluk, Yang Liu, Nicola Alesi, Geraldine A Finlay, Chin-Lee Wu, Sabina Signoretti, Matthew Meyerson, Gad Getz, Jesse S Boehm, Elizabeth P Henske, David J Kwiatkowski
Renal angiomyolipoma is a kidney tumor in the perivascular epithelioid (PEComa) family that is common in patients with Tuberous Sclerosis Complex (TSC) and Lymphangioleiomyomatosis (LAM) but occurs rarely sporadically. Though histologically benign, renal angiomyolipoma can cause life-threatening hemorrhage and kidney failure. Both angiomyolipoma and LAM have mutations in TSC2 or TSC1. However, the frequency and contribution of other somatic events in tumor development is unknown. We performed whole exome sequencing in 32 resected tumor samples (n = 30 angiomyolipoma, n = 2 LAM) from 15 subjects, including three with TSC...
August 2016: PLoS Genetics
https://www.readbyqxmd.com/read/27301072/ultrafast-multi-slice-spatiotemporally-encoded-mri-with-slice-selective-dimension-segmented
#12
Ting Zhang, Lin Chen, Jianpan Huang, Jing Li, Shuhui Cai, Congbo Cai, Zhong Chen
As a recently emerging method, spatiotemporally encoded (SPEN) magnetic resonance imaging (MRI) has a high robustness to field inhomogeneity and chemical shift effect. It has been broadened from single-slice scanning to multi-slice scanning. In this paper, a novel multi-slice SPEN MRI method was proposed. In this method, the slice-selective dimension was segmented to lower the specific absorption rate (SAR) and improve the image quality. This segmented method, dubbed SeSPEN method, was theoretically analyzed and demonstrated with phantom, lemon and in vivo rat brain experiments...
August 2016: Journal of Magnetic Resonance
https://www.readbyqxmd.com/read/27248326/xist-reduction-in-breast-cancer-upregulates-akt-phosphorylation-via-hdac3-mediated-repression-of-phlpp1-expression
#13
Yen-Sung Huang, Che-Chang Chang, Szu-Shuo Lee, Yuh-Shan Jou, Hsiu-Ming Shih
Long noncoding RNAs (lncRNAs) dysregulated in cancer potentially play oncogenic or tumor-suppressive roles. While the X inactivate-specific transcript (Xist) lncRNA is important for X-chromosome inactivation in female cells, very little is known about the role of Xist in human breast cancer in modulating cellular pathway(s). Here, we show that Xist expression is significantly reduced in breast tumor samples and cancer cell lines. Xist knockdown or overexpression resulted in increased or decreased levels, respectively, of AKT phosphorylation and cell viability...
July 12, 2016: Oncotarget
https://www.readbyqxmd.com/read/27203401/reducing-sar-requirements-in-multislice-volumetric-single-shot-spatiotemporal-mri-by-two-dimensional-rf-pulses
#14
Gilad Liberman, Lucio Frydman
PURPOSE: Spatiotemporal encoding (SPEN) can deliver single-scan MR images without folding complications and with increased robustness to chemical shift and susceptibility artifacts. Yet, it does so at the expense of relatively high specific absorption rates (SAR) owing to its reliance on frequency-swept pulses. This study describes SPEN implementations aimed at full three-dimensional (3D) multislice imaging, possessing reduced SAR thanks to an implementation based on new 2D radiofrequency (RF) pulses...
May 2017: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/27180905/rna-duplex-map-in-living-cells-reveals-higher-order-transcriptome-structure
#15
Zhipeng Lu, Qiangfeng Cliff Zhang, Byron Lee, Ryan A Flynn, Martin A Smith, James T Robinson, Chen Davidovich, Anne R Gooding, Karen J Goodrich, John S Mattick, Jill P Mesirov, Thomas R Cech, Howard Y Chang
RNA has the intrinsic property to base pair, forming complex structures fundamental to its diverse functions. Here, we develop PARIS, a method based on reversible psoralen crosslinking for global mapping of RNA duplexes with near base-pair resolution in living cells. PARIS analysis in three human and mouse cell types reveals frequent long-range structures, higher-order architectures, and RNA-RNA interactions in trans across the transcriptome. PARIS determines base-pairing interactions on an individual-molecule level, revealing pervasive alternative conformations...
May 19, 2016: Cell
https://www.readbyqxmd.com/read/27120691/a-fast-chemical-exchange-saturation-transfer-imaging-scheme-based-on-single-shot-spatiotemporal-encoding
#16
Jianpan Huang, Miao Zhang, Jianhua Lu, Congbo Cai, Lin Chen, Shuhui Cai
PURPOSE: To design a new approach that can not only keep the spatial and temporal resolution but also have better built-in immunity to magnetic field inhomogeneity and chemical shift effects than the single-shot echo planar imaging (EPI) for chemical exchange saturation transfer (CEST) MRI. METHOD: The single-shot spatiotemporally encoded (SPEN) MRI sequence was combined with a continuous wave saturation pulse for fast CEST MRI (CEST-SPEN MRI). The resulting images were super-resolved reconstructed by a hybrid method that solves the l1 norm minimization together with total variation (TV) regularization...
April 27, 2016: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/27046905/test-and-validation-of-a-smart-exercise-bike-for-motor-rehabilitation-in-individuals-with-parkinson-s-disease
#17
Hassan Mohammadi-Abdar, Angela L Ridgel, Fred M Discenzo, Robert S Phillips, Benjamin L Walter, Kenneth A Loparo
To assess and validate the Smart Exercise Bike designed for Parkinson's Disease (PD) rehabilitation, 47 individuals with PD were randomly assigned to either the static or dynamic cycling group, and completed three sessions of exercise. Heart rate, cadence and power data were captured and recorded for each patient during exercise. Motor function for each subject was assessed with the UPDRS Motor III test before and after the three exercise sessions to evaluate the effect of exercise on functional abilities. Individuals who completed three sessions of dynamic cycling showed an average of 13...
November 2016: IEEE Transactions on Neural Systems and Rehabilitation Engineering
https://www.readbyqxmd.com/read/27001497/visual-information-representation-and-rapid-scene-categorization-are-simultaneous-across-cortex-an-meg-study
#18
Pavan Ramkumar, Bruce C Hansen, Sebastian Pannasch, Lester C Loschky
Perceiving the visual world around us requires the brain to represent the features of stimuli and to categorize the stimulus based on these features. Incorrect categorization can result either from errors in visual representation or from errors in processes that lead to categorical choice. To understand the temporal relationship between the neural signatures of such systematic errors, we recorded whole-scalp magnetoencephalography (MEG) data from human subjects performing a rapid-scene categorization task. We built scene category decoders based on (1) spatiotemporally resolved neural activity, (2) spatial envelope (SpEn) image features, and (3) behavioral responses...
July 1, 2016: NeuroImage
https://www.readbyqxmd.com/read/26987936/the-humanitarian-common-logistic-operating-picture-a-solution-to-the-inter-agency-coordination-challenge
#19
Peter Tatham, Karen Spens, Gyöngyi Kovács
Although significant progress has been made in developing the practice of humanitarian logistics, further improvements in efficiency and effectiveness have the potential to save lives and reduce suffering. This paper explores how the military/emergency services' concept of a common operating picture (COP) can be adapted to the humanitarian logistics context, and analyses a practical and proven approach to addressing the key challenge of inter-agency coordination and decision-making. Successful adaptation could provide the mechanism through which predicted and actual demands, together with the location and status of material in transit, are captured, evaluated, and presented in real time as the basis for enhanced decision-making between actors in the humanitarian supply network...
January 2017: Disasters
https://www.readbyqxmd.com/read/26968710/robust-diffusion-tensor-imaging-by-spatiotemporal-encoding-principles-and-in-vivo-demonstrations
#20
Eddy Solomon, Gilad Liberman, Noam Nissan, Lucio Frydman
PURPOSE: Evaluate the usefulness of single-shot and of interleaved spatiotemporally encoded (SPEN) methods to perform diffusion tensor imaging (DTI) under various preclinical and clinical settings. METHODS: A formalism for analyzing SPEN DTI data is presented, tailored to account for the spatially dependent b-matrix weightings introduced by the sequence's use of swept pulses acting while in the presence of field gradients. Using these b-matrix calculations, SPEN's ability to deliver DTI measurements was tested on phantoms as well as ex vivo and in vivo...
March 2017: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
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