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Nataliya Shamsutdinova, Rustem Zairov, Irek Nizameev, Aidar Gubaidullin, Alsu Mukhametshina, Sergey Podyachev, Ildus Ismayev, Marsil Kadirov, Alexandra Voloshina, Timur Mukhametzyanov, Asiya Mustafina
The present work introduces an impact of polyelectrolyte-based hydrophilic shell on magnetic relaxivity and luminescence of hard cores built from isostructural complexes of Tb(III) and Gd(III) in the core-shell aqueous colloids. Microscopic and scattering techniques reveal "plum pudding" morphology of the colloids, where polyelectrolyte-coated ultrasmall (<5nm) hard cores form aggregates in aqueous solutions. Interaction of bovine serum albumin (BSA) with the colloids provides a tool to modify the polyelectrolyte-based shell, which is the reason for the improvement in both aggregation behavior of the colloids and their relaxivity...
November 11, 2017: Colloids and Surfaces. B, Biointerfaces
Xianwen Wang, Fei Li, Xu Yan, Yan Ma, Zhaohua Miao, Liang Dong, Huajian Chen, Yang Lu, Zhengbao Zha
Big size induced long-term retention in the body has hampered the translational applications of many reported nanomedicine. Herein, we reported a multifunctional theranostic agent composed of ultrasmall polyacrylic acid functionalized Ni0.85Se nanoparticles (PAA-Ni0.85Se NPs), which were successfully obtained through a facile ambient aqueous precipitation strategy. Without exhibiting any noticeable toxicity, the as-prepared PAA-Ni0.85Se NPs (average diameter of 6.40 ± 1.89 nm) showed a considerable absorption in near-infrared (NIR) region and high photothermal conversion efficiency (PTCE) of 54...
November 17, 2017: ACS Applied Materials & Interfaces
Bo Chen, Chan Zhang, Libo Niu, Xiaozhen Shi, Huiling Zhang, Xingwang Lan, Guoyi Bai
Ultrasmall ZnO nanoparticles anchored on N-doped carbons with silica support (ZnO/SiO2-NC) were fabricated from chitosan and metal ions using a one-pot self-assembly strategy, and were successfully applied to the synthesis of 2-arylbenzimidazoles under mild conditions. These catalysts showed excellent stability and could be used six times without loss of conversion and selectivity. Using silica gel and biomass chitosan as a source of hydrophilic N-doped carbon facilitated the uniform dispersion of the ZnO nanoparticles in methanol and therefore their contact with reactants, contributing to a high catalytic performance...
November 17, 2017: Chemistry: a European Journal
Yong'an Tang, Tao Yang, Qiaoli Wang, Xiaoyan Lv, Xue Song, Hengte Ke, Zhengqing Guo, Xiaoqing Huang, Jun Hu, Zifu Li, Peng Yang, Xiangliang Yang, Huabing Chen
Photoactive noble metal nanoparticles are of increasing importance toward personalized cancer therapy in the field of precision nanomedicine. A critical challenge remains in the exploration of clinically potential noble metal nanoparticles for highly efficient cancer theranostics. Here, we introduce albumin-coordinated assembly of clearable Pt nanodots (Pt-NDs) with monodisperse nanostructure as high-performance theranostic agents for imaging-guided photothermal tumor ablation. We precisely manipulate the reduction and growth of tetravalent Pt ions into ultrasmall nanodots through albumin-directed growth kinetics, thereby leading to the synthesis of monodisperse 6...
October 20, 2017: Biomaterials
Feng Chen, Kai Ma, Miriam Benezra, Li Zhang, Sarah M Cheal, Evan Phillips, Barney Yoo, Mohan Pauliah, Michael Overholtzer, Pat Zanzonico, Sonia Sequeira, Mithat Gonen, Thomas Quinn, Ulrich Wiesner, Michelle S Bradbury
Although a large body of literature exists on the potential use of nanoparticles for medical applications, the number of probes translated into human clinical trials is remarkably small. A major challenge of particle probe development and their translation is the elucidation of safety profiles associated with their structural complexity, not only in terms of size distribution and heterogeneities in particle composition but also their effects on biological activities and the relationship between particle structure and pharmacokinetics...
October 24, 2017: Chemistry of Materials: a Publication of the American Chemical Society
Feng Chen, Kai Ma, Li Zhang, Brian Madajewski, Pat Zanzonico, Sonia Sequeira, Mithat Gonen, Ulrich Wiesner, Michelle S Bradbury
Designing a nanomaterials platform with high target-to-background ratios has long been one of the major challenges in the field of nanomedicine. Here, we introduce a "target-or-clear" multifunctional nanoparticle platform that demonstrates high tumor-targeting efficiency and retention while minimizing off-target effects. Encouraged by the favorable preclinical and clinical pharmacokinetic profiles derived after fine-tuning surface chemical properties of radioiodinated ((124)I, t1/2 = 100.2 h) ultrasmall cRGDY-conjugated fluorescent silica nanoparticles (C dots), we sought to investigate how the biological properties of these radioconjugates could be influenced by the conjugation of radiometals such as zirconium-89 ((89)Zr, t1/2 = 78...
October 10, 2017: Chemistry of Materials: a Publication of the American Chemical Society
Anna Cifuentes-Rius, Angela Ivask, Shreya Das, Nuria Penya Auladell, Laura Fabregas, Nicholas L Fletcher, Zachary H Houston, Kristofer James Thurecht, Nicolas H Voelcker
Gold nanoclusters (Au NCs) have become a promising nanomaterial for cancer therapy due to their biocompatibility and fluorescent properties. In this study, the effect of ultrasmall protein-stabilized 2 nm Au NCs on six types of mammalian cells (fibroblasts, B-lymphocytes, glioblastoma, neuroblastoma, and two types of prostate cancer cells) under electromagnetic radiation is investigated. Cellular association of Au NCs in vitro is concentration-dependent and Au NCs have low intrinsic toxicity. However, when Au NC-incubated cells are exposed to 1 GHz electromagnetic field (microwave radiation, µW), cell viability significantly decreases thus demonstrating that Au NCs exhibit specific µW dependent cytotoxicity, likely resulting from localized heating...
November 8, 2017: ACS Applied Materials & Interfaces
Yibing Xu, Qiang Zhang, Longfei Lv, Wenqian Han, Guanhong Wu, Dong Yang, Angang Dong
Discretely sized semiconductor clusters have attracted considerable attention due to their intriguing optical properties and self-assembly behaviors. While lead halide perovskite nanostructures have been recently intensively explored, few studies have addressed perovskite clusters and their self-assembled superstructures. Here, we report the room-temperature synthesis of sub-2 nm CsPbBr3 clusters and present strong evidence that these ultrasmall perovskite species, obtained under a wide range of reaction conditions, possess a specific size, with optical properties and self-assembly characteristics resembling those of well-known II-VI semiconductor magic-sized clusters...
November 16, 2017: Nanoscale
Zhiqiang Wang, Jin-Nan Xuan, Zhigang Zhao, Qingwen Li, Fengxia Geng
As a recently created inorganic nanosheet material, MXene has received growing attention and has become a hotspot of intensive research. The efficient morphology control of this class of material would bring enormous possibilities for creating marvelous properties and functions; however, this type of research is very scarce. In this work, we demonstrated a general and mild approach for creating ultrasmall MXenes by simultaneous intralayer cutting and interlayer delamination. Taking the most commonly studied Ti3C2 as an illustrative example, the resulting product possessed monolayer thickness with a lateral dimension of 2-8 nm and exhibited bright and tunable fluorescence...
November 7, 2017: ACS Nano
Christoph Jud, Eva Braig, Martin Dierolf, Elena Eggl, Benedikt Günther, Klaus Achterhold, Bernhard Gleich, Ernst Rummeny, Peter Noël, Franz Pfeiffer, Daniela Muenzel
Conventional x-ray radiography is a well-established standard in diagnostic imaging of human bones. It reveals typical bony anatomy with a strong surrounding cortical bone and trabecular structure of the inner part. However, due to limited spatial resolution, x-ray radiography cannot provide information on the microstructure of the trabecular bone. Thus, microfractures without dislocation are often missed in initial radiographs, resulting in a lack or delay of adequate therapy. Here we show that x-ray vector radiography (XVR) can overcome this limitation and allows for a deeper insight into the microstructure with a radiation exposure comparable to standard radiography...
November 3, 2017: Scientific Reports
Shuohui Yang, Jiang Lin, Fang Lu, Zhihong Han, Caixia Fu, Hongchen Gu
We investigated effectiveness of ultrasmall superparamagnetic iron oxide enhanced susceptibility weighted imaging (USPIO-enhanced SWI) and mean vessel density imaging (Q) in monitoring antiangiogenic effects of Sorafenib on orthotopic hepatocellular carcinoma (HCC). Thirty-five HCC xenografts were established. USPIO-enhanced SWI and Q were performed on a 1.5 T MR scanner at baseline, 7, 14, and 21 days after Sorafenib treatment. Intratumoral susceptibility signal intensity (ITSS) and Q were serially measured and compared between the treated (n = 15) and control groups (n = 15)...
2017: Contrast Media & Molecular Imaging
Yan Xu
A significant growth of research in nanofluidics is achieved over the past decade, but the field is still facing considerable challenges toward the transition from the current physics-centered stage to the next application-oriented stage. Many of these challenges are associated with materials science, so the field of nanofluidics offers great opportunities for materials scientists to exploit. In addition, the use of unusual effects and ultrasmall confined spaces of well-defined nanofluidic environments would offer new mechanisms and technologies to manipulate nanoscale objects as well as to synthesize novel nanomaterials in the liquid phase...
November 2, 2017: Advanced Materials
Haibin Wu, Fangyuan Li, Shuaifei Wang, Jingxiong Lu, Jinquan Li, Yang Du, Xiaolian Sun, Xiaoyuan Chen, Jianqing Gao, Daishun Ling
Restoration of tissue integrity and tissue function of wounded skin are both essential for wound repair and regeneration, while synergistic promotion of the two remains elusive. Since elevated reactive oxygen species (ROS) production in the injured site has been implicated in triggering a set of deleterious effects such as cellular senescence, fibrotic scarring, and inflammation, it is speculated that alleviating oxidative stress in the microenvironment of injured site would be beneficial to promote regenerative wound healing...
October 12, 2017: Biomaterials
Joseph J Pancrazio, Felix Deku, Atefeh Ghazavi, Allison M Stiller, Rashed Rihani, Christopher L Frewin, Victor D Varner, Timothy J Gardner, Stuart F Cogan
OBJECTIVES: Neural stimulation is well-accepted as an effective therapy for a wide range of neurological disorders. While the scale of clinical devices is relatively large, translational, and pilot clinical applications are underway for microelectrode-based systems. Microelectrodes have the advantage of stimulating a relatively small tissue volume which may improve selectivity of therapeutic stimuli. Current microelectrode technology is associated with chronic tissue response which limits utility of these devices for neural recording and stimulation...
October 27, 2017: Neuromodulation: Journal of the International Neuromodulation Society
Souleymane Kamara, Quang-Hung Tran, Vincent Davesne, Gautier Félix, Lionel Salmon, Kunwoo Kim, CheolGi Kim, Azzedine Bousseksou, Ferial Terki
A promising and original method to study the spin-transition in bistable spin-crossover (SCO) materials using a magnetoresistive multiring sensor and its self-generated magnetic field is reported. Qualitative and quantitative studies are carried out combining theoretical and experimental approaches. The results show that only a small part of matter dropped on the sensor surface is probed by the device. At a low bias-current range, the number of detected nanoparticles depends on the amplitude of the current...
October 25, 2017: Advanced Materials
Xinle Li, Biying Zhang, Linlin Tang, Tian Wei Goh, Shuyan Qi, Alexander Volkov, Yuchen Pei, Zhiyuan Qi, Chia-Kuang Tsung, Levi Stanley, Wenyu Huang
Nitrones are key intermediates in organic synthesis and the pharmaceutical industry. The heterogeneous synthesis of nitrones with multifunctional catalysts is extremely attractive but rarely explored. Herein, we report ultrasmall platinum nanoclusters (Pt NCs) encapsulated in amine-functionalized UiO-66-NH₂ (Pt@UiO-66-NH₂) as a multifunctional catalyst in the one-pot tandem synthesis of nitrones. By virtue of the cooperative interplay among the selective hydrogenation activity provided by the ultrasmall Pt NCs and Lewis acidity/basicity/nanoconfinement endowed by UiO-66-NH₂, Pt@UiO-66-NH₂ exhibits remarkable activity and selectivity, in comparison to Pt/carbon, Pt@UiO-66, and Pd@UiO-66-NH₂...
October 24, 2017: Angewandte Chemie
Anne Kerbrat, Benoit Combès, Olivier Commowick, Adil Maarouf, Elise Bannier, Jean Christophe Ferré, Ayman Tourbah, Jean-Philippe Ranjeva, Christian Barillot, Gilles Edan
BACKGROUND: Identifying in vivo the processes that determine lesion severity in multiple sclerosis (MS) remains a challenge. OBJECTIVES: To describe the dynamics of ultrasmall superparamagnetic iron oxide (USPIO) enhancement in MS lesions and the relationship between USPIO enhancement and microstructural changes over 3 years. METHODS: Lesion development was assessed at baseline, Months 3, 6, and 9, using magnetic resonance imaging (MRI) with gadolinium and USPIO...
October 1, 2017: Multiple Sclerosis: Clinical and Laboratory Research
Ketki Bhise, Samaresh Sau, Hashem Alsaab, Sushil Kumar Kashaw, Rakesh Kumar Tekade, Arun K Iyer
Multifunctional nanoparticles (NPs), composed of organic and inorganic materials, have been explored as promising drug-delivery vehicles for cancer diagnosis and therapy. The success of nanosystems has been attributed to its smaller size, biocompatibility, selective tumor accumulation and reduced toxicity. The relationship among numbers of molecules in payload, NP diameter and encapsulation efficacy have crucial role in clinical translation. Advancement of bioengineering, and systematic fine-tuning of functional components to NPs have diversified their optical and theranostic properties...
November 2017: Therapeutic Delivery
Feng Chen, Xiuli Zhang, Kai Ma, Brian Madajewski, Miriam Benezra, Li Zhang, Evan Phillips, Melik Ziya Turker, Fabio Gallazzi, Michael Overholtzer, Mohan Pauliah, Mithat Gonen, Pat Zanzonico, Ulrich B Wiesner, Michelle S Bradbury, Thomas Quinn
The poor prognosis associated with malignant melanoma has not changed substantially over the past 30 years. Targeted molecular therapies, such as immunotherapy have shown promise, but suffer from resistance and off-target toxicities, underscoring the need for alternative therapeutic strategies that can be used in combination with existing protocols. Moreover, peptides targeting melanoma-specific markers, like the melanocortin-1 receptor (MC1-R), for imaging and therapy exhibit high renal uptake that limits clinical translation...
October 23, 2017: ACS Applied Materials & Interfaces
Yan Sun, Tao Wang, Ang Li, Ling Zhang, Qisheng Huo, Zhen-An Qiao
Hierarchical porous polymers with more than one pore size distributions can effectively support noble metal catalysts and circumvent the limitation of the diffusion of the reactants, and thus exhibit both excellent catalytic activity and superior diffusive properties. Herein, we report a simple one-step Friedel-Crafts reaction to knit a series of benzene heterocycle monomers, such as indane, indoline, indole and tetrahydronaphthalene to obtain hierarchical porous polymers with high surface areas and/or abundant N sites...
October 16, 2017: Chemistry, An Asian Journal
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