Rim Sghiri, Hana Benhassine, Khadija Baccouche, Meriem Ghozzi, Sarra Jriri, Zahid Shakoor, Adel Almogren, Foued Slama, Nadia Idriss, Zeineb Benlamine, Elyes Bouajina, Ramzi Zemni
OBJECTIVES: Little is known about genes predisposing to systemic bone loss (SBL) in rheumatoid arthritis (RA). Therefore, we examined the association between SBL and variants of genes playing a critical role in both immune response and bone homeostasis among patients with RA. METHODS: IRAK-1 rs3027898, IRAK-2 rs3844283, IRAK-2 rs708035, IFIH1 rs1990760, CD40 rs48104850, TNFAIP3 rs2230926, and miR146-a rs2910164 were genotyped in 176 adult RA patients. Bone mineral density (BMD) was measured using dual-energy X-ray absorptiometry (DXA)...
February 2, 2022: Clinical Rheumatology