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accelerated diagnostic protocol

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https://www.readbyqxmd.com/read/27891190/cell-free-dna-promoter-hypermethylation-in-plasma-as-a-diagnostic-marker-for-pancreatic-adenocarcinoma
#1
Stine Dam Henriksen, Poul Henning Madsen, Anders Christian Larsen, Martin Berg Johansen, Asbjørn Mohr Drewes, Inge Søkilde Pedersen, Henrik Krarup, Ole Thorlacius-Ussing
BACKGROUND: Pancreatic cancer has a 5-year survival rate of only 5-7%. Difficulties in detecting pancreatic cancer at early stages results in the high mortality and substantiates the need for additional diagnostic tools. Surgery is the only curative treatment and unfortunately only possible in localized tumours. A diagnostic biomarker for pancreatic cancer will have a major impact on patient survival by facilitating early detection and the possibility for curative treatment. DNA promoter hypermethylation is a mechanism of early carcinogenesis, which can cause inactivation of tumour suppressor genes...
2016: Clinical Epigenetics
https://www.readbyqxmd.com/read/27744578/comparing-an-accelerated-3d-fast-spin-echo-sequence-cs-space-for-knee-3-t-magnetic-resonance-imaging-with-traditional-3d-fast-spin-echo-space-and-routine-2d-sequences
#2
Faysal F Altahawi, Kevin J Blount, Nicholas P Morley, Esther Raithel, Imran M Omar
PURPOSE: To compare a faster, new, high-resolution accelerated 3D-fast-spin-echo (3D-FSE) acquisition sequence (CS-SPACE) to traditional 2D and high-resolution 3D sequences for knee 3-T magnetic resonance imaging (MRI). MATERIALS AND METHODS: Twenty patients received knee MRIs that included routine 2D (T1, PD ± FS, T2-FS; 0.5 × 0.5 × 3 mm(3); ∼10 min), traditional 3D FSE (SPACE-PD-FS; 0.5 × 0.5 × 0.5 mm(3); ∼7.5 min), and accelerated 3D-FSE prototype (CS-SPACE-PD-FS; 0...
October 15, 2016: Skeletal Radiology
https://www.readbyqxmd.com/read/27735933/the-real-time-quaking-induced-conversion-assay-for-detection-of-human-prion-disease-and-study-of-other-protein-misfolding-diseases
#3
Matthias Schmitz, Maria Cramm, Franc Llorens, Dominik Müller-Cramm, Steven Collins, Ryuichiro Atarashi, Katsuya Satoh, Christina D Orrù, Bradley R Groveman, Saima Zafar, Walter J Schulz-Schaeffer, Byron Caughey, Inga Zerr
The development and adaption of in vitro misfolded protein amplification systems has been a major innovation in the detection of abnormally folded prion protein scrapie (PrP(Sc)) in human brain and cerebrospinal fluid (CSF) samples. Herein, we describe a fast and efficient protein amplification technique, real-time quaking-induced conversion (RT-QuIC), for the detection of a PrP(Sc) seed in human brain and CSF. In contrast to other in vitro misfolded protein amplification assays-such as protein misfolding cyclic amplification (PMCA)-which are based on sonication, the RT-QuIC technique is based on prion seed-induced misfolding and aggregation of recombinant prion protein substrate, accelerated by alternating cycles of shaking and rest in fluorescence plate readers...
November 2016: Nature Protocols
https://www.readbyqxmd.com/read/27698176/a-randomised-controlled-study-of-standard-versus-accelerated-deflation-of-the-terumo-radial-band-haemostasis-device-after-transradial-diagnostic-cardiac-catheterisation
#4
J Han Deuling, Robert P Vermeulen, Ad Fm van den Heuvel, Remco Aj Schurer, Pim van der Harst
BACKGROUND: Radial access is the preferential access route in patients undergoing diagnostic coronary angiography. We hypothesised that we could reduce hospital stay and improve patient comfort by accelerated deflation of the radial compression device (Terumo radial band). AIMS: The aim of this study was to compare accelerated pressure reduction with a standard Terumo radial band protocol with regard to local bleeding complications and reported pain scores after cardiac catheterisation...
October 3, 2016: European Journal of Cardiovascular Nursing
https://www.readbyqxmd.com/read/27692518/treatment-planning-strategy-for-whole-brain-radiotherapy-with-hippocampal-sparing-and-simultaneous-integrated-boost-for-multiple-brain-metastases-using-intensity-modulated-arc-therapy
#5
Damodar Pokhrel, Sumit Sood, Christopher McClinton, Xinglei Shen, Christopher Lominska, Habeeb Saleh, Rajeev Badkul, Hongyu Jiang, Melissa Mitchell, Fen Wang
PURPOSE: To retrospectively evaluate the accuracy, plan quality and efficiency of intensity-modulated arc therapy (IMAT) for hippocampal sparing whole-brain radiotherapy (HS-WBRT) with simultaneous integrated boost (SIB) in patients with multiple brain metastases (m-BM). MATERIALS AND METHODS: A total of 5 patients with m-BM were retrospectively replanned for HS-WBRT with SIB using IMAT treatment planning. The hippocampus was contoured on diagnostic T1-weighted magnetic resonance imaging (MRI) which had been fused with the planning CT image set...
September 27, 2016: Medical Dosimetry: Official Journal of the American Association of Medical Dosimetrists
https://www.readbyqxmd.com/read/27669521/feasibility-and-safety-of-evaluating-patients-with-prior-coronary-artery-disease-using-an-accelerated-diagnostic-algorithm-in-a-chest-pain-unit
#6
Roy Beigel, Alexander Fardman, Ronen Goldkorn, Orly Goitein, Sagit Ben-Zekery, Nir Shlomo, Michael Narodetsky, Moran Livne, Avi Sabbag, Elad Asher, Shlomi Matetzky
An accelerated diagnostic protocol for evaluating low-risk patients with acute chest pain in a cardiologist-based chest pain unit (CPU) is widely employed today. However, limited data exist regarding the feasibility of such an algorithm for patients with a history of prior coronary artery disease (CAD). The aim of the current study was to assess the feasibility and safety of evaluating patients with a history of prior CAD using an accelerated diagnostic protocol. We evaluated 1,220 consecutive patients presenting with acute chest pain and hospitalized in our CPU...
2016: PloS One
https://www.readbyqxmd.com/read/27335077/an-extrapolation-of-a-radical-equation-more-accurately-predicts-shelf-life-of-frozen-biological-matrices
#7
Karl W De Vore, Nadia M Fatahi, John E Sass
BACKGROUND: Arrhenius modeling of analyte recovery at increased temperatures to predict long-term colder storage stability of biological raw materials, reagents, calibrators, and controls is standard practice in the diagnostics industry. Predicting subzero temperature stability using the same practice is frequently criticized but nevertheless heavily relied upon. We compared the ability to predict analyte recovery during frozen storage using 3 separate strategies: traditional accelerated studies with Arrhenius modeling, and extrapolation of recovery at 20% of shelf life using either ordinary least squares or a radical equation y = B1x(0...
August 2016: Clinical Chemistry
https://www.readbyqxmd.com/read/27312789/magnetic-resonance-imaging-for-precise-radiotherapy-of-small-laboratory-animals
#8
Thorsten Frenzel, Michael Gerhard Kaul, Thomas Michael Ernst, Johannes Salamon, Maria Jäckel, Udo Schumacher, Andreas Krüll
AIMS: Radiotherapy of small laboratory animals (SLA) is often not as precisely applied as in humans. Here we describe the use of a dedicated SLA magnetic resonance imaging (MRI) scanner for precise tumor volumetry, radiotherapy treatment planning, and diagnostic imaging in order to make the experiments more accurate. METHODS AND MATERIALS: Different human cancer cells were injected at the lower trunk of pfp/rag2 and SCID mice to allow for local tumor growth. Data from cross sectional MRI scans were transferred to a clinical treatment planning system (TPS) for humans...
June 13, 2016: Zeitschrift Für Medizinische Physik
https://www.readbyqxmd.com/read/27270345/cutaneous-lupus-erythematosus-updates-on-pathogenesis-and-associations-with-systemic-lupus
#9
Jasmine N Stannard, J Michelle Kahlenberg
PURPOSE OF REVIEW: Cutaneous lupus erythematosus (CLE) is a common manifestation among systemic lupus patients. There are no U.S. Food and Drug Administration approved therapies for CLE, and these lesions are frequently disfiguring and refractory to treatment. The present review will cover the recent inroads made into understanding the mechanisms behind CLE lesions and discuss promising therapeutic developments. RECENT FINDINGS: The definition of cutaneous lupus is being refined to facilitate diagnostic and research protocols...
September 2016: Current Opinion in Rheumatology
https://www.readbyqxmd.com/read/27183253/chest-pain-risk-stratification-a-comparison-of-the-2-hour-accelerated-diagnostic-protocol-adapt-and-the-heart-pathway
#10
Jason P Stopyra, Chadwick D Miller, Brian C Hiestand, Cedric W Lefebvre, Bret A Nicks, David M Cline, Kim L Askew, Robert F Riley, Gregory B Russell, Greg L Burke, David Herrington, James W Hoekstra, Simon A Mahler
BACKGROUND: The 2-hour accelerated diagnostic protocol (ADAPT) and the history electrocardiogram age risk factors troponin (HEART) Pathway are decision aids designed to identify Emergency Department (ED) patients with chest pain who are safe for early discharge. Both have demonstrated high sensitivity (>99%) for major adverse cardiac events (MACE) at 30 days and early discharge rates ≥20%. The objective of this study is to compare the sensitivity and early discharge rates of the ADAPT and HEART Pathway decision aids in a cohort of ED patients with acute chest pain...
June 2016: Critical Pathways in Cardiology
https://www.readbyqxmd.com/read/27162612/transthoracic-echocardiography-in-the-evaluation-of-pediatric-pulmonary-hypertension-and-ventricular-dysfunction
#11
REVIEW
Martin Koestenberger, Mark K Friedberg, Eirik Nestaas, Ina Michel-Behnke, Georg Hansmann
Transthoracic echocardiography (TTE) is the most accessible noninvasive diagnostic procedure for the initial assessment of pediatric pulmonary hypertension (PH). This review focuses on principles and use of TTE to determine morphologic and functional parameters that are also useful for follow-up investigations in pediatric PH patients. A basic echocardiographic study of a patient with PH commonly includes the hemodynamic calculation of the systolic pulmonary artery pressure (PAP), the mean and diastolic PAP, the pulmonary artery acceleration time, and the presence of a pericardial effusion...
March 2016: Pulmonary Circulation
https://www.readbyqxmd.com/read/27150464/the-pharmacogenomics-of-bipolar-disorder-study-pgbd-identification-of-genes-for-lithium-response-in-a-prospective-sample
#12
Ketil J Oedegaard, Martin Alda, Anit Anand, Ole A Andreassen, Yokesh Balaraman, Wade H Berrettini, Abesh Bhattacharjee, Kristen J Brennand, Katherine E Burdick, Joseph R Calabrese, Cynthia V Calkin, Ana Claasen, William H Coryell, David Craig, Anna DeModena, Mark Frye, Fred H Gage, Keming Gao, Julie Garnham, Elliot Gershon, Petter Jakobsen, Susan G Leckband, Michael J McCarthy, Melvin G McInnis, Adam X Maihofer, Jerome Mertens, Gunnar Morken, Caroline M Nievergelt, John Nurnberger, Son Pham, Helle Schoeyen, Tatyana Shekhtman, Paul D Shilling, Szabolcs Szelinger, Bruce Tarwater, Jun Yao, Peter P Zandi, John R Kelsoe
BACKGROUND: Bipolar disorder is a serious and common psychiatric disorder characterized by manic and depressive mood switches and a relapsing and remitting course. The cornerstone of clinical management is stabilization and prophylaxis using mood-stabilizing medications to reduce both manic and depressive symptoms. Lithium remains the gold standard of treatment with the strongest data for both efficacy and suicide prevention. However, many patients do not respond to this medication, and clinically there is a great need for tools to aid the clinician in selecting the correct treatment...
May 5, 2016: BMC Psychiatry
https://www.readbyqxmd.com/read/27130152/a-two-step-protocol-for-isolation-of-influenza-a-h7n7-virions-and-their-rna-for-pcr-diagnostics-based-on-modified-paramagnetic-particles
#13
Petr Michalek, Simona Dostalova, Hana Buchtelova, Natalia Cernei, Ludmila Krejcova, David Hynek, Vedran Milosavljevic, Ana Maria Jimenez Jimenez, Pavel Kopel, Zbynek Heger, Vojtech Adam
Annual epidemics of influenza cause death of hundreds of thousands people and they also have a significant economic impact. Hence, a need for fast and cheap influenza diagnostic method is arising. The conventional methods for an isolation of the viruses are time-consuming and require expensive instrumentation as well as trained personnel. In this study, we modified the surface of nanomaghemite (γ-Fe2 O3 ) paramagnetic core with tetraethyl orthosilicate and (3-aminopropyl)triethoxysilane and the resulting particles were utilized for the isolation of H7N7 influenza virions...
July 2016: Electrophoresis
https://www.readbyqxmd.com/read/27096160/single-patient-molecular-testing-with-nanostring-ncounter-data-using-a-reference-based-strategy-for-batch-effect-correction
#14
Aline Talhouk, Stefan Kommoss, Robertson Mackenzie, Martin Cheung, Samuel Leung, Derek S Chiu, Steve E Kalloger, David G Huntsman, Stephanie Chen, Maria Intermaggio, Jacek Gronwald, Fong C Chan, Susan J Ramus, Christian Steidl, David W Scott, Michael S Anglesio
A major weakness in many high-throughput genomic studies is the lack of consideration of a clinical environment where one patient at a time must be evaluated. We examined generalizable and platform-specific sources of variation from NanoString gene expression data on both ovarian cancer and Hodgkin lymphoma patients. A reference-based strategy, applicable to single-patient molecular testing is proposed for batch effect correction. The proposed protocol improved performance in an established Hodgkin lymphoma classifier, reducing batch-to-batch misclassification while retaining accuracy and precision...
2016: PloS One
https://www.readbyqxmd.com/read/26980207/developing-a-clinical-translational-neuroscience-taxonomy-for-anxiety-and-mood-disorder-protocol-for-the-baseline-follow-up-research-domain-criteria-anxiety-and-depression-rad-project
#15
Leanne M Williams, Andrea N Goldstein-Piekarski, Nowreen Chowdhry, Katherine A Grisanzio, Nancy A Haug, Zoe Samara, Amit Etkin, Ruth O'Hara, Alan F Schatzberg, Trisha Suppes, Jerome Yesavage
BACKGROUND: Understanding how brain circuit dysfunctions relate to specific symptoms offers promise for developing a brain-based taxonomy for classifying psychopathology, identifying targets for mechanistic studies and ultimately for guiding treatment choice. The goal of the Research Domain Criteria (RDoC) initiative of the National Institute of Mental Health is to accelerate the development of such neurobiological models of mental disorder independent of traditional diagnostic criteria...
2016: BMC Psychiatry
https://www.readbyqxmd.com/read/26968957/community-and-district-empowerment-for-scale-up-codes-a-complex-district-level-management-intervention-to-improve-child-survival-in-uganda-study-protocol-for-a-randomized-controlled-trial
#16
Peter Waiswa, Thomas O'Connell, Danstan Bagenda, Pricila Mullachery, Flavia Mpanga, Dorcus Kiwanuka Henriksson, Anne Ruhweza Katahoire, Eric Ssegujja, Anthony K Mbonye, Stefan Swartling Peterson
BACKGROUND: Innovative and sustainable strategies to strengthen districts and other sub-national health systems and management are urgently required to reduce child mortality. Although highly effective evidence-based and affordable child survival interventions are well-known, at the district level, lack of data, motivation, analytic and planning capacity often impedes prioritization and management weaknesses impede implementation. The Community and District Empowerment for Scale-up (CODES) project is a complex management intervention designed to test whether districts when empowered with data and management tools can prioritize and implement evidence-based child survival interventions equitably...
2016: Trials
https://www.readbyqxmd.com/read/26947397/scalable-chromatography-based-purification-of-virus-like-particle-carrier-for-epitope-based-influenza-a-vaccine-produced-in-escherichia-coli
#17
Priscillia Lagoutte, Charlotte Mignon, Stéphanie Donnat, Gustavo Stadthagen, Jan Mast, Régis Sodoyer, Adrien Lugari, Bettina Werle
Virus-like particles (VLPs) are promising molecular structures for the design and construction of novel vaccines, diagnostic tools, and gene therapy vectors. Size, oligomer assembly and repetitiveness of epitopes are optimal features to induce strong immune responses. Several VLP-based vaccines are currently licensed and commercialized, and many vaccine candidates are now under preclinical and clinical studies. In recent years, the development of genetically engineered recombinant VLPs has accelerated the need for new, improved downstream processes...
June 2016: Journal of Virological Methods
https://www.readbyqxmd.com/read/26916691/change-to-costs-and-lengths-of-stay-in-the-emergency-department-and-the-brisbane-protocol-an-observational-study
#18
Qinglu Cheng, Jaimi H Greenslade, William A Parsonage, Adrian G Barnett, Katharina Merollini, Nicholas Graves, W Frank Peacock, Louise Cullen
OBJECTIVE: To compare health service cost and length of stay between a traditional and an accelerated diagnostic approach to assess acute coronary syndromes (ACS) among patients who presented to the emergency department (ED) of a large tertiary hospital in Australia. DESIGN, SETTING AND PARTICIPANTS: This historically controlled study analysed data collected from two independent patient cohorts presenting to the ED with potential ACS. The first cohort of 938 patients was recruited in 2008-2010, and these patients were assessed using the traditional diagnostic approach detailed in the national guideline...
2016: BMJ Open
https://www.readbyqxmd.com/read/26838947/computer-program-for-analysis-of-parathyroid-scintigraphy-examinations-combination-of-dual-tracer-subtraction-and-double-phase-single-tracer-washout-techniques
#19
LETTER
Małgorzata Iwona Kobylecka, Adam Bajera, Katarzyna Fronczewska-Wieniawska, Joanna Mączewska, Maria Teresa Płazińska, Leszek Królicki
There is no controversy in the published literature that sensitivity and specificity of parathyroid scintigraphy is superior to other imaging techniques. However no uniform protocol has been established for scintigraphy. In order to analyze parathyroid scintigraphic images in the Department of Nuclear Medicine at the Medical University of Warsaw we have developed a program that allows qualitative and quantitative evaluation of recorded images and motion artifacts correction. This program offers a uniform procedure of analysis of parathyroid imaging results in diagnostic centers, accelerates the analysis of parathyroid tests performed with use of single radioactive tracer, that require the acquisition of consecutive images of the patient, without altering his body position between successive stages of registration...
2016: Nuclear Medicine Review. Central & Eastern Europe
https://www.readbyqxmd.com/read/26829612/examining-radiation-induced-in-vivo-and-in-vitro-gene-expression-changes-of-the-peripheral-blood-in-different-laboratories-for-biodosimetry-purposes-first-reneb-gene-expression-study
#20
MULTICENTER STUDY
M Abend, C Badie, R Quintens, R Kriehuber, G Manning, E Macaeva, M Njima, D Oskamp, S Strunz, S Moertl, S Doucha-Senf, S Dahlke, J Menzel, M Port
The risk of a large-scale event leading to acute radiation exposure necessitates the development of high-throughput methods for providing rapid individual dose estimates. Our work addresses three goals, which align with the directive of the European Union's Realizing the European Network of Biodosimetry project (EU-RENB): 1. To examine the suitability of different gene expression platforms for biodosimetry purposes; 2. To perform this examination using blood samples collected from prostate cancer patients (in vivo) and from healthy donors (in vitro); and 3...
February 2016: Radiation Research
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