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https://www.readbyqxmd.com/read/28187516/collaborating-to-compete-blood-profiling-atlas-in-cancer-bloodpac-consortium
#1
R L Grossman, B Abel, S Angiuoli, J C Barrett, D Bassett, K Bramlett, G M Blumenthal, A Carlsson, R Cortese, J DiGiovanna, B Davis-Dusenbery, R Dittamore, D A Eberhard, P Febbo, M Fitzsimons, Z Flamig, J Godsey, J Goswami, A Gruen, F O Guzman, J Han, D Hayes, J Hicks, D Holloway, D Hovelson, J Johnson, H Juhl, R Kalamegham, R Kamal, Q Kang, G J Kelloff, M Klozenbuecher, A Kolatkar, P Kuhn, K Langone, R Leary, P Loverso, H Manmathan, A-M Martin, J Martini, D Miller, M Mitchell, T Morgan, R Mulpuri, T Nguyen, G Otto, A Pathak, E Peters, R Philip, E Posadas, D Reese, M G Reese, D Robinson, A D Rossi, H Sakul, J Schageman, S Singh, H I Scher, K Schmitt, A Silvestro, J Simmons, T Simmons, J Sislow, A Talasaz, P Tang, M Tewari, S Tomlins, H Toukhy, H R Tseng, M Tuck, A Tzou, J Vinson, Y Wang, W Wells, A Welsh, J Wilbanks, J Wolf, L Young, J S H Lee, L C Leiman
The cancer community understands the value of blood profiling measurements in assessing and monitoring cancer. We describe an effort amongst academic, government, biotechnology, diagnostic, and pharmaceutical companies called the Blood Profiling Atlas in Cancer (BloodPAC) Project. BloodPAC will aggregate, make freely available, and harmonize for further analyses, raw datasets, relevant associated clinical data (e.g. clinical diagnosis, treatment history and outcomes), and sample preparation and handling protocols to accelerate the development of blood profiling assays...
February 10, 2017: Clinical Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/28157539/the-undiagnosed-diseases-network-accelerating-discovery-about-health-and-disease
#2
Rachel B Ramoni, John J Mulvihill, David R Adams, Patrick Allard, Euan A Ashley, Jonathan A Bernstein, William A Gahl, Rizwan Hamid, Joseph Loscalzo, Alexa T McCray, Vandana Shashi, Cynthia J Tifft, Anastasia L Wise
Diagnosis at the edges of our knowledge calls upon clinicians to be data driven, cross-disciplinary, and collaborative in unprecedented ways. Exact disease recognition, an element of the concept of precision in medicine, requires new infrastructure that spans geography, institutional boundaries, and the divide between clinical care and research. The National Institutes of Health (NIH) Common Fund supports the Undiagnosed Diseases Network (UDN) as an exemplar of this model of precise diagnosis. Its goals are to forge a strategy to accelerate the diagnosis of rare or previously unrecognized diseases, to improve recommendations for clinical management, and to advance research, especially into disease mechanisms...
February 2, 2017: American Journal of Human Genetics
https://www.readbyqxmd.com/read/28110382/economic-evaluations-alongside-efficient-study-designs-using-large-observational-datasets-the-pleasant-trial-case-study
#3
Matthew Franklin, Sarah Davis, Michelle Horspool, Wei Sun Kua, Steven Julious
BACKGROUND: Large observational datasets such as Clinical Practice Research Datalink (CPRD) provide opportunities to conduct clinical studies and economic evaluations with efficient designs. OBJECTIVES: Our objectives were to report the economic evaluation methodology for a cluster randomised controlled trial (RCT) of a UK NHS-delivered public health intervention for children with asthma that was evaluated using CPRD and describe the impact of this methodology on results...
January 21, 2017: PharmacoEconomics
https://www.readbyqxmd.com/read/28106936/whole-brain-vessel-wall-mri-a-parameter-tune-up-solution-to-improve-the-scan-efficiency-of-three-dimensional-variable-flip-angle-turbo-spin-echo
#4
Qi Yang, Zixin Deng, Xiaoming Bi, Shlee S Song, Konrad H Schlick, Nestor R Gonzalez, Debiao Li, Zhaoyang Fan
PURPOSE: To propose and evaluate a parameter tune-up solution to expedite a three-dimensional (3D) variable-flip-angle turbo spin-echo (TSE) sequence for whole-brain intracranial vessel wall (IVW) imaging. MATERIALS AND METHODS: Elliptical k-space sampling and prolonged echo train length (ETL), were used to expedite a 3D variable-flip-angle TSE-based sequence. To compensate for the potential loss in vessel wall signal, optimal combination of prescribed T2 and ETL was experimentally investigated on 22 healthy volunteers at 3 Tesla...
January 20, 2017: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/28087265/myocardial-relaxation-is-accelerated-by-fast-stretch-not-reduced-afterload
#5
Charles S Chung, Charles W Hoopes, Kenneth S Campbell
Fast relaxation of cross-bridge generated force in the myocardium facilitates efficient diastolic function. Recently published research studying mechanisms that modulate the relaxation rate has focused on molecular factors. Mechanical factors have received less attention since the 1980s when seminal work established the theory that reducing afterload accelerates the relaxation rate. Clinical trials using afterload reducing drugs, partially based on this theory, have thus far failed to improve outcomes for patients with diastolic dysfunction...
January 11, 2017: Journal of Molecular and Cellular Cardiology
https://www.readbyqxmd.com/read/28062616/early-rule-out-and-rule-in-strategies-for-myocardial-infarction
#6
REVIEW
Louise A Cullen, Nicholas L Mills, Simon Mahler, Richard Body
BACKGROUND: Patients with chest pain comprise a large proportion of emergency presentations and place a major burden on healthcare resources. Therefore, efforts to safely and rapidly identify those with and without acute myocardial infarction (AMI) are needed. The challenge for clinicians is to accurately identify patients with acute coronary syndromes, while balancing the need to safely and rapidly reassure and discharge those without serious conditions. CONTENT: This review summarizes the evidence to date on optimum accelerated strategies for the rule-in and rule-out of AMI, using strategies focused on optimum use of troponin results...
January 2017: Clinical Chemistry
https://www.readbyqxmd.com/read/28043600/benefits-and-challenges-of-molecular-diagnostics-for-childhood-tuberculosis
#7
Cristina Gutierrez
Expanding tuberculosis (TB)-diagnostic services, including access to rapid tests, is a World Health Organization (WHO) strategy to accelerate progress toward ending TB. Faster and more sensitive molecular tests capable of diagnosing TB and drug-resistant TB have the technical capacity to address limitations associated with smears and cultures by increasing accuracy and shortening turnaround times as compared with those of these conventional laboratory methods. Nucleic acid amplification assays used to detect and analyze Mycobacterium tuberculosis (MTB)-complex nucleic acids can be used directly on specimens from patients suspected of having TB...
December 2016: International Journal of Mycobacteriology
https://www.readbyqxmd.com/read/27931558/time-to-shift-from-contemporary-to-high-sensitivity-cardiac-troponin-in-diagnosis-of-acute-coronary-syndromes
#8
REVIEW
Jamshed J Dalal, C K Ponde, Brian Pinto, C N Srinivas, Joy Thomas, Sunil Kumar Modi, Sanjay Mehta, Suvin Shetty, Manimarane, Bhupen Desai
Early rule-in and rule-out of non-ST-segment elevation myocardial infarction (NSTEMI) is a challenge. In patients with inconclusive findings on ECG, cardiac biomarkers play a crucial role in the diagnosis. The introduction of the new high-sensitive cardiac troponin test (hs-TnI assay) has changed the landscape of NSTEMI diagnosis. The new hs-TnI assay can detect troponin values at a lower level compared with a contemporary cardiac troponin (cTn) assay. The hs-cTnI assay has a coefficient of variation of ≤10%, well below the 99th percentile value...
November 2016: Indian Heart Journal
https://www.readbyqxmd.com/read/27891190/cell-free-dna-promoter-hypermethylation-in-plasma-as-a-diagnostic-marker-for-pancreatic-adenocarcinoma
#9
Stine Dam Henriksen, Poul Henning Madsen, Anders Christian Larsen, Martin Berg Johansen, Asbjørn Mohr Drewes, Inge Søkilde Pedersen, Henrik Krarup, Ole Thorlacius-Ussing
BACKGROUND: Pancreatic cancer has a 5-year survival rate of only 5-7%. Difficulties in detecting pancreatic cancer at early stages results in the high mortality and substantiates the need for additional diagnostic tools. Surgery is the only curative treatment and unfortunately only possible in localized tumours. A diagnostic biomarker for pancreatic cancer will have a major impact on patient survival by facilitating early detection and the possibility for curative treatment. DNA promoter hypermethylation is a mechanism of early carcinogenesis, which can cause inactivation of tumour suppressor genes...
2016: Clinical Epigenetics
https://www.readbyqxmd.com/read/27744578/comparing-an-accelerated-3d-fast-spin-echo-sequence-cs-space-for-knee-3-t-magnetic-resonance-imaging-with-traditional-3d-fast-spin-echo-space-and-routine-2d-sequences
#10
Faysal F Altahawi, Kevin J Blount, Nicholas P Morley, Esther Raithel, Imran M Omar
PURPOSE: To compare a faster, new, high-resolution accelerated 3D-fast-spin-echo (3D-FSE) acquisition sequence (CS-SPACE) to traditional 2D and high-resolution 3D sequences for knee 3-T magnetic resonance imaging (MRI). MATERIALS AND METHODS: Twenty patients received knee MRIs that included routine 2D (T1, PD ± FS, T2-FS; 0.5 × 0.5 × 3 mm(3); ∼10 min), traditional 3D FSE (SPACE-PD-FS; 0.5 × 0.5 × 0.5 mm(3); ∼7.5 min), and accelerated 3D-FSE prototype (CS-SPACE-PD-FS; 0...
January 2017: Skeletal Radiology
https://www.readbyqxmd.com/read/27735933/the-real-time-quaking-induced-conversion-assay-for-detection-of-human-prion-disease-and-study-of-other-protein-misfolding-diseases
#11
Matthias Schmitz, Maria Cramm, Franc Llorens, Dominik Müller-Cramm, Steven Collins, Ryuichiro Atarashi, Katsuya Satoh, Christina D Orrù, Bradley R Groveman, Saima Zafar, Walter J Schulz-Schaeffer, Byron Caughey, Inga Zerr
The development and adaption of in vitro misfolded protein amplification systems has been a major innovation in the detection of abnormally folded prion protein scrapie (PrP(Sc)) in human brain and cerebrospinal fluid (CSF) samples. Herein, we describe a fast and efficient protein amplification technique, real-time quaking-induced conversion (RT-QuIC), for the detection of a PrP(Sc) seed in human brain and CSF. In contrast to other in vitro misfolded protein amplification assays-such as protein misfolding cyclic amplification (PMCA)-which are based on sonication, the RT-QuIC technique is based on prion seed-induced misfolding and aggregation of recombinant prion protein substrate, accelerated by alternating cycles of shaking and rest in fluorescence plate readers...
November 2016: Nature Protocols
https://www.readbyqxmd.com/read/27698176/a-randomised-controlled-study-of-standard-versus-accelerated-deflation-of-the-terumo-radial-band-haemostasis-device-after-transradial-diagnostic-cardiac-catheterisation
#12
J Han Deuling, Robert P Vermeulen, Ad Fm van den Heuvel, Remco Aj Schurer, Pim van der Harst
BACKGROUND: Radial access is the preferential access route in patients undergoing diagnostic coronary angiography. We hypothesised that we could reduce hospital stay and improve patient comfort by accelerated deflation of the radial compression device (Terumo radial band). AIMS: The aim of this study was to compare accelerated pressure reduction with a standard Terumo radial band protocol with regard to local bleeding complications and reported pain scores after cardiac catheterisation...
October 3, 2016: European Journal of Cardiovascular Nursing
https://www.readbyqxmd.com/read/27692518/treatment-planning-strategy-for-whole-brain-radiotherapy-with-hippocampal-sparing-and-simultaneous-integrated-boost-for-multiple-brain-metastases-using-intensity-modulated-arc-therapy
#13
Damodar Pokhrel, Sumit Sood, Christopher McClinton, Xinglei Shen, Christopher Lominska, Habeeb Saleh, Rajeev Badkul, Hongyu Jiang, Melissa Mitchell, Fen Wang
PURPOSE: To retrospectively evaluate the accuracy, plan quality and efficiency of intensity-modulated arc therapy (IMAT) for hippocampal sparing whole-brain radiotherapy (HS-WBRT) with simultaneous integrated boost (SIB) in patients with multiple brain metastases (m-BM). MATERIALS AND METHODS: A total of 5 patients with m-BM were retrospectively replanned for HS-WBRT with SIB using IMAT treatment planning. The hippocampus was contoured on diagnostic T1-weighted magnetic resonance imaging (MRI) which had been fused with the planning CT image set...
January 2016: Medical Dosimetry: Official Journal of the American Association of Medical Dosimetrists
https://www.readbyqxmd.com/read/27669521/feasibility-and-safety-of-evaluating-patients-with-prior-coronary-artery-disease-using-an-accelerated-diagnostic-algorithm-in-a-chest-pain-unit
#14
Roy Beigel, Alexander Fardman, Ronen Goldkorn, Orly Goitein, Sagit Ben-Zekery, Nir Shlomo, Michael Narodetsky, Moran Livne, Avi Sabbag, Elad Asher, Shlomi Matetzky
An accelerated diagnostic protocol for evaluating low-risk patients with acute chest pain in a cardiologist-based chest pain unit (CPU) is widely employed today. However, limited data exist regarding the feasibility of such an algorithm for patients with a history of prior coronary artery disease (CAD). The aim of the current study was to assess the feasibility and safety of evaluating patients with a history of prior CAD using an accelerated diagnostic protocol. We evaluated 1,220 consecutive patients presenting with acute chest pain and hospitalized in our CPU...
2016: PloS One
https://www.readbyqxmd.com/read/27335077/an-extrapolation-of-a-radical-equation-more-accurately-predicts-shelf-life-of-frozen-biological-matrices
#15
Karl W De Vore, Nadia M Fatahi, John E Sass
BACKGROUND: Arrhenius modeling of analyte recovery at increased temperatures to predict long-term colder storage stability of biological raw materials, reagents, calibrators, and controls is standard practice in the diagnostics industry. Predicting subzero temperature stability using the same practice is frequently criticized but nevertheless heavily relied upon. We compared the ability to predict analyte recovery during frozen storage using 3 separate strategies: traditional accelerated studies with Arrhenius modeling, and extrapolation of recovery at 20% of shelf life using either ordinary least squares or a radical equation y = B1x(0...
August 2016: Clinical Chemistry
https://www.readbyqxmd.com/read/27312789/magnetic-resonance-imaging-for-precise-radiotherapy-of-small-laboratory-animals
#16
Thorsten Frenzel, Michael Gerhard Kaul, Thomas Michael Ernst, Johannes Salamon, Maria Jäckel, Udo Schumacher, Andreas Krüll
AIMS: Radiotherapy of small laboratory animals (SLA) is often not as precisely applied as in humans. Here we describe the use of a dedicated SLA magnetic resonance imaging (MRI) scanner for precise tumor volumetry, radiotherapy treatment planning, and diagnostic imaging in order to make the experiments more accurate. METHODS AND MATERIALS: Different human cancer cells were injected at the lower trunk of pfp/rag2 and SCID mice to allow for local tumor growth. Data from cross sectional MRI scans were transferred to a clinical treatment planning system (TPS) for humans...
June 13, 2016: Zeitschrift Für Medizinische Physik
https://www.readbyqxmd.com/read/27270345/cutaneous-lupus-erythematosus-updates-on-pathogenesis-and-associations-with-systemic-lupus
#17
Jasmine N Stannard, J Michelle Kahlenberg
PURPOSE OF REVIEW: Cutaneous lupus erythematosus (CLE) is a common manifestation among systemic lupus patients. There are no U.S. Food and Drug Administration approved therapies for CLE, and these lesions are frequently disfiguring and refractory to treatment. The present review will cover the recent inroads made into understanding the mechanisms behind CLE lesions and discuss promising therapeutic developments. RECENT FINDINGS: The definition of cutaneous lupus is being refined to facilitate diagnostic and research protocols...
September 2016: Current Opinion in Rheumatology
https://www.readbyqxmd.com/read/27183253/chest-pain-risk-stratification-a-comparison-of-the-2-hour-accelerated-diagnostic-protocol-adapt-and-the-heart-pathway
#18
Jason P Stopyra, Chadwick D Miller, Brian C Hiestand, Cedric W Lefebvre, Bret A Nicks, David M Cline, Kim L Askew, Robert F Riley, Gregory B Russell, Greg L Burke, David Herrington, James W Hoekstra, Simon A Mahler
BACKGROUND: The 2-hour accelerated diagnostic protocol (ADAPT) and the history electrocardiogram age risk factors troponin (HEART) Pathway are decision aids designed to identify Emergency Department (ED) patients with chest pain who are safe for early discharge. Both have demonstrated high sensitivity (>99%) for major adverse cardiac events (MACE) at 30 days and early discharge rates ≥20%. The objective of this study is to compare the sensitivity and early discharge rates of the ADAPT and HEART Pathway decision aids in a cohort of ED patients with acute chest pain...
June 2016: Critical Pathways in Cardiology
https://www.readbyqxmd.com/read/27162612/transthoracic-echocardiography-in-the-evaluation-of-pediatric-pulmonary-hypertension-and-ventricular-dysfunction
#19
REVIEW
Martin Koestenberger, Mark K Friedberg, Eirik Nestaas, Ina Michel-Behnke, Georg Hansmann
Transthoracic echocardiography (TTE) is the most accessible noninvasive diagnostic procedure for the initial assessment of pediatric pulmonary hypertension (PH). This review focuses on principles and use of TTE to determine morphologic and functional parameters that are also useful for follow-up investigations in pediatric PH patients. A basic echocardiographic study of a patient with PH commonly includes the hemodynamic calculation of the systolic pulmonary artery pressure (PAP), the mean and diastolic PAP, the pulmonary artery acceleration time, and the presence of a pericardial effusion...
March 2016: Pulmonary Circulation
https://www.readbyqxmd.com/read/27150464/the-pharmacogenomics-of-bipolar-disorder-study-pgbd-identification-of-genes-for-lithium-response-in-a-prospective-sample
#20
MULTICENTER STUDY
Ketil J Oedegaard, Martin Alda, Anit Anand, Ole A Andreassen, Yokesh Balaraman, Wade H Berrettini, Abesh Bhattacharjee, Kristen J Brennand, Katherine E Burdick, Joseph R Calabrese, Cynthia V Calkin, Ana Claasen, William H Coryell, David Craig, Anna DeModena, Mark Frye, Fred H Gage, Keming Gao, Julie Garnham, Elliot Gershon, Petter Jakobsen, Susan G Leckband, Michael J McCarthy, Melvin G McInnis, Adam X Maihofer, Jerome Mertens, Gunnar Morken, Caroline M Nievergelt, John Nurnberger, Son Pham, Helle Schoeyen, Tatyana Shekhtman, Paul D Shilling, Szabolcs Szelinger, Bruce Tarwater, Jun Yao, Peter P Zandi, John R Kelsoe
BACKGROUND: Bipolar disorder is a serious and common psychiatric disorder characterized by manic and depressive mood switches and a relapsing and remitting course. The cornerstone of clinical management is stabilization and prophylaxis using mood-stabilizing medications to reduce both manic and depressive symptoms. Lithium remains the gold standard of treatment with the strongest data for both efficacy and suicide prevention. However, many patients do not respond to this medication, and clinically there is a great need for tools to aid the clinician in selecting the correct treatment...
May 5, 2016: BMC Psychiatry
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