keyword
https://read.qxmd.com/read/37164759/zebrafish-imaging-reveals-hidden-oncogenic-normal-cell-communication-during-primary-tumorigenesis
#21
JOURNAL ARTICLE
Yukinari Haraoka, Mai Miyake, Tohru Ishitani
Oncogenic mutations drive tumorigenesis, and single cells with oncogenic mutations act as the tumor seeds that gradually evolve into fully transformed tumors. However, oncogenic cell behavior and communication with neighboring cells during primary tumorigenesis remain poorly understood. We used the zebrafish, a small vertebrate model suitable for in vivo cell biology, to address these issues. We describe the cooperative and competitive communication between oncogenic cells and neighboring cells, as revealed by our recent zebrafish imaging studies...
May 11, 2023: Cell Structure and Function
https://read.qxmd.com/read/37148059/looking-beyond-the-anterolateral-skull-base-with-frontotemporal-dural-fold-unlocking-and-extradural-clinoidectomy-a-series-of-17-cases-deciphering-the-translation-from-a-cadaver-to-real-and-real-to-pathologically-distorted-anatomy
#22
MULTICENTER STUDY
Ashutosh Kumar, Arun K Srivastava, Shashwat Mishra, Kamlesh S Bhaisora, Kuntal K Das, Pawan K Verma, Awadhesh K Jaiswal, Sanjay Behari
OBJECTIVE: This article aims to discuss the surgical nuances and major adjustments necessary in unlocking the frontotemporal dural fold (FTDF) and extradural anterior clinoidectomy (EDAC) in actual cases, allowing translation from the cadaveric to a clinical scenario. MATERIALS AND METHODS: We retrospectively reviewed the technical details of 17 procedures over 8 years, where both the initial steps (FTDF unlocking and EDAC) were performed. Lesions involving or extending to the anterolateral skull base, like the suprasellar cistern, optico-carotid cistern, interpeduncular cistern, petrous apex, and cavernous sinus, were included...
2023: Neurology India
https://read.qxmd.com/read/37131096/personalized-diagnosis-in-suspected-myocardial-infarction
#23
JOURNAL ARTICLE
Johannes Tobias Neumann, Raphael Twerenbold, Francisco Ojeda, Sally J Aldous, Brandon R Allen, Fred S Apple, Hugo Babel, Robert H Christenson, Louise Cullen, Eleonora Di Carluccio, Dimitrios Doudesis, Ulf Ekelund, Evangelos Giannitsis, Jaimi Greenslade, Kenji Inoue, Tomas Jernberg, Peter Kavsak, Till Keller, Kuan Ken Lee, Bertil Lindahl, Thiess Lorenz, Simon A Mahler, Nicholas L Mills, Arash Mokhtari, William Parsonage, John W Pickering, Christopher J Pemberton, Christoph Reich, A Mark Richards, Yader Sandoval, Martin P Than, Betül Toprak, Richard W Troughton, Andrew Worster, Tanja Zeller, Andreas Ziegler, Stefan Blankenberg
BACKGROUND: In suspected myocardial infarction (MI), guidelines recommend using high-sensitivity cardiac troponin (hs-cTn)-based approaches. These require fixed assay-specific thresholds and timepoints, without directly integrating clinical information. Using machine-learning techniques including hs-cTn and clinical routine variables, we aimed to build a digital tool to directly estimate the individual probability of MI, allowing for numerous hs-cTn assays. METHODS: In 2,575 patients presenting to the emergency department with suspected MI, two ensembles of machine-learning models using single or serial concentrations of six different hs-cTn assays were derived to estimate the individual MI probability (ARTEMIS model)...
May 2, 2023: Clinical Research in Cardiology: Official Journal of the German Cardiac Society
https://read.qxmd.com/read/36999946/excessive-dynamic-airway-collapse-severity-scoring-system-a-call-out-for-an-overall-severity-determination
#24
JOURNAL ARTICLE
David Abia-Trujillo, Alejandra Yu Lee-Mateus, Daniel Hernandez-Rojas, Sai Priyanka Pulipaka, Juan C Garcia-Saucedo, Omran Saifi, Adnan Majid, Sebastian Fernandez-Bussy
BACKGROUND: Severe excessive dynamic airway collapse (EDAC) is defined as airway narrowing due to posterior wall protrusion into the airway lumen, >90%. We aimed to establish an overall severity score to assess severe EDAC and the need for subsequent intervention. METHODS: A retrospective study of patients who underwent dynamic bronchoscopy for evaluation of expiratory central airway collapse between January 2019 and July 2021. A numerical value was given to each tracheobronchial segmental collapse: 0 points (<70%), 1 point (70% to 79%), 2 points (80% to 89%), and 3 points (>90%) to be added for an overall EDAC severity score per patient...
March 31, 2023: Journal of Bronchology & Interventional Pulmonology
https://read.qxmd.com/read/36910102/nocturnal-continuous-positive-airway-pressure-offers-symptomatic-benefit-in-excessive-dynamic-airway-collapse-despite-normal-sleep-study
#25
JOURNAL ARTICLE
Louise Olley, Joerg Steier, Georgios Kaltsakas
Excessive dynamic airway collapse (EDAC) and tracheobronchomalacia (TBM) cause debilitating symptoms yet are often misdiagnosed as asthma or chronic obstructive pulmonary disease (COPD). EDAC/TBM should be considered in all cases of obstructive ventilatory defect refractory to medical management. Diagnosis is made with flexible bronchoscopy and/or inspiratory and expiratory phase computed tomography (CT) scans. Treatment should be individualised and "pneumatic stenting" with the use of continuous positive airway pressure (CPAP) may lead to symptomatic relief, and in some cases regardless of the degree of collapse or absence of sleep disordered breathing in overnight oximetry...
February 28, 2023: Journal of Thoracic Disease
https://read.qxmd.com/read/36868948/immune-response-of-s-typhi-derived-vi-polysaccharide-and-outer-membrane-protein-a-conjugate-in-mice
#26
JOURNAL ARTICLE
Shabirul Haque, Sanjukta Sengupta, Azhar Khan, Asok Kumar Mukhopadhyay, Maharaj Kishan Bhan, Ramesh Kumar, Bansilal Jailkhani
Typhoid fever is a serious concern precisely in developing nations. Still investigators are exploring a better conjugate partner for Vi-polysaccharide to develop a more effective vaccine for typhoid fever. Here, we cloned and expressed S. Typhi outer membrane protein A (OmpA). The conjugation of Vi-polysaccharide with OmpA was carried out by the carbodiimide (EDAC) method employing ADH as a linker. Total Ig and IgG generated against OmpA, and Vi polysaccharide was quantified by ELISA. Vi polysaccharide alone induced very low levels of Vi polysaccharide antibody...
February 18, 2023: Pediatrics and Neonatology
https://read.qxmd.com/read/36680685/optimization-of-the-process-for-preparing-bivalent-polysaccharide-conjugates-to-develop-multivalent-conjugate-vaccines-against-streptococcus-pneumoniae-or-neisseria-meningitidis-and-comparison-with-the-corresponding-licensed-vaccines-in-animal-models
#27
JOURNAL ARTICLE
Fang Huang, Xiao-Bing Jing, Yin-Bo Li, Qian Wang, Si-Li Liu, Zhi-Rong Yang, Su Feng
OBJECTIVE: This study aimed to describe, optimize and evaluate a method for preparing multivalent conjugate vaccines by simultaneous conjugation of two different bacterial capsular polysaccharides (CPs) with tetanus toxoid (TT) as bivalent conjugates. METHODS: Different molecular weights (MWs) of polysaccharides, activating agents and capsular polysaccharide/protein (CP/Pro) ratio that may influence conjugation and immunogenicity were investigated and optimized to prepare the bivalent conjugate bulk...
January 21, 2023: Current Medical Science
https://read.qxmd.com/read/36633287/relationship-between-nutritional-status-and-severity-of-cerebral-palsy-a-multicentre-cross-sectional-study
#28
MULTICENTER STUDY
Yiting Zhao, Hongmei Tang, Tingting Peng, Jinling Li, Liru Liu, Chaoqiong Fu, Hongyu Zhou, Shiya Huang, Yuan Huang, Peishan Zeng, Wenda Wang, Lu He, Kaihsou Xu
BACKGROUND: Nutritional problems are common in children with cerebral palsy (CP), yet the relationship between nutritional status and the severity of CP is unclear. OBJECTIVE: To describe the nutritional status and characteristics of children with CP, and to explore the relationship between severity of CP and nutritional status in children. METHODS: This multicentre cross-sectional study included children with CP in China. Weight and height were measured and converted to z-scores...
January 12, 2023: Journal of Rehabilitation Medicine
https://read.qxmd.com/read/36526315/validation-of-a-classification-to-identify-emergency-department-visits-suitable-for-subacute-and-virtual-care-models-a-randomised-single-blinded-agreement-study-protocol
#29
JOURNAL ARTICLE
Ryan P Strum, Shawn Mondoux, Fabrice Mowbray, Andrew Worster, Lauren E Griffith, Walter Tavares, Paul Miller, Erich Hanel, Komal Aryal, Ravi Sivakumaran, Andrew P Costa
INTRODUCTION: Redirecting suitable patients from the emergency department (ED) to alternative subacute settings may assist in reducing ED overcrowding while delivering equivalent care. The Emergency Department Avoidance Classification (EDAC) was constructed to retrospectively classify ED visits that may have been suitable for safe management in a subacute or virtual clinical setting. The EDAC has established face and content validity but has not been tested against a reference standard as a criterion...
December 16, 2022: BMJ Open
https://read.qxmd.com/read/36436300/performance-analysis-considering-endpoints-for-three-accelerated-diagnostic-protocols-for-chest-pain
#30
JOURNAL ARTICLE
Bora Chae, Shin Ahn, Seung Mok Ryoo, Youn-Jung Kim, Dong-Woo Seo, Chang Hwan Sohn, Won Young Kim
INTRODUCTION: The modified accelerated diagnostic protocol (ADP) to assess patients with chest pain symptoms using troponin as the only biomarker (mADAPT), the History, ECG, Age, Risk factors, and Troponin (HEART) pathway, and the Emergency Department Assessment of Chest Pain Rule (EDACS)-ADP, are the three most well-known ADPs for patients with chest pain. These ADPs define major adverse cardiac event (MACE) as components of acute myocardial infarction, revascularization, and death; unstable angina is not included as an endpoint...
February 2023: American Journal of Emergency Medicine
https://read.qxmd.com/read/36279748/development-and-characterisation-of-3d-collagen-gelatin-based-scaffolds-for-breast-cancer-research
#31
JOURNAL ARTICLE
John Redmond, Helen O McCarthy, Paul Buchanan, Tanya J Levingstone, Nicholas J Dunne
While 2D culture presents a useful tool for cancer research, it fails to replicate the tumor microenvironment as it lacks proper three-dimensional cell-cell/cell-matrix interactions, often resulting in exaggerated responses to therapeutic agents. 3D models that aim to overcome the issues associated with 2D culture research offer a new frontier for cancer research with cell growth, morphology and genetic properties that more closely match in vivo cancers. Herein, we aim to develop a collagen-based scaffold that supports the attachment and proliferation of breast cancer (BC) cells as a 3D culture model...
October 17, 2022: Biomater Adv
https://read.qxmd.com/read/36188909/comparative-efficacy-of-botulinum-toxin-in-salivary-glands-vs-oromotor-therapy-in-the-management-of-sialorrhea-in-cerebral-palsy-impact-on-sleep-quality
#32
JOURNAL ARTICLE
Juan Francisco Marquez-Vazquez, María Elena Arellano-Saldaña, Karla Nayeli Rojas-Martinez, Paul Carrillo-Mora
Aims: The aim of this study was to compare the effects of intraglandular abobotuliniumtoxinA application and oromotor therapy in the management of sialorrhea in patients with cerebral palsy and its effect on sleep quality. Methods: A comparative study ( n = 134), mean age 7.1 years (± 3.9 years) was performed in pediatric patients, between the efficacy of abobotuliniumtoxinA in salivary glands and oromotor therapy (JT), with a control group receiving exclusive oromotor therapy (EOMT)...
2022: Front Rehabil Sci
https://read.qxmd.com/read/35857007/-functional-characterization-of-patients-with-cerebral-palsy-living-in-the-magallanes-region-and-the-chilean-antarctic
#33
JOURNAL ARTICLE
Patricio Barria Aburto, Vanessa Barria Ruiz, Matías Castillo Aguilar, Rolando Aguilar Cárdenas, Asterio Andrade Gallardo, Cristian Núñez-Espinosa
OBJECTIVE: To functionally characterize patients with Cerebral Palsy (CP) living in the Magallanes Re gion and the Chilean Antarctic. PATIENT AND METHOD: Descriptive-retrospective observational study of patients with cerebral palsy, registered in the Outpatient Rehabilitation Program of the Corporación de Rehabilitación Club de Leones Cruz del Sur de Punta Arenas between 1986 and 2018. Patients with CP were clinically categorized and then functionally characterized according to gross motor skills (GMFCS), manual ability (MACS), feeding ability (EDACS), and communication function (CFCS)...
June 2022: Andes pediatrica: revista Chilena de pediatría
https://read.qxmd.com/read/35796779/pleiotropic-effects-of-cell-competition-between-normal-and-transformed-cells-in-mammalian-cancers
#34
REVIEW
Jing Yu, Yamin Zhang, Huiyong Zhu
PURPOSE: In the course of tumor progression, cancer clones interact with host normal cells, and these interactions make them under selection pressure all the time. Cell competition, which can eliminate suboptimal cells and optimize organ development via comparison of cell fitness information, is found to take place between host cells and transformed cells in mammals and play important roles in different phases of tumor progression. The aim of this study is to summarize the current knowledge about the roles and corresponding mechanisms of different cell competition interactions between host normal cells and transformed cells involved in mammalian tumor development...
July 7, 2022: Journal of Cancer Research and Clinical Oncology
https://read.qxmd.com/read/35656080/recombinant-pbp2a-autolysin-conjugate-as-plga-based-nanovaccine-induced-humoral-responses-with-opsonophagocytosis-activity-and-protection-versus-methicillin-resistant-staphylococcus-aureus-infection
#35
JOURNAL ARTICLE
Setareh Haghighat, Seyed Davar Siadat, Abbas Akhavan Sepahi, Mehdi Mahdavi
Objectives: Methicillin-resistant Staphylococcus aureus (MRSA) reasons extreme infections, can resist various conventional antimicrobial agents, and cause morbidity and mortality worldwide. Vaccination seems to help modulate MRSA infections. Nanovaccine is considered a novel strategy in vaccine technology. The primary purpose of the present study was to develop a conjugate vaccine based on recombinant PBP2a and MRSA autolysin formulated in PLGA as a nanoparticle capable of enhancing protective responses against MRSA in the murine model...
April 2022: Iranian Journal of Basic Medical Sciences
https://read.qxmd.com/read/35522576/tracheobronchomalacia-and-excessive-dynamic-airway-collapse-current-concepts-and-future-directions
#36
JOURNAL ARTICLE
Anum Aslam, Jose De Luis Cardenas, Robert J Morrison, Kiran H Lagisetty, Diana Litmanovich, Edith Carolina Sella, Elizabeth Lee, Prachi P Agarwal
Tracheobronchomalacia (TBM) and excessive dynamic airway collapse (EDAC) are airway abnormalities that share a common feature of expiratory narrowing but are distinct pathophysiologic entities. Both entities are collectively referred to as expiratory central airway collapse (ECAC). The malacia or weakness of cartilage that supports the tracheobronchial tree may occur only in the trachea (ie, tracheomalacia), in both the trachea and bronchi (TBM), or only in the bronchi (bronchomalacia). On the other hand, EDAC refers to excessive anterior bowing of the posterior membrane into the airway lumen with intact cartilage...
2022: Radiographics: a Review Publication of the Radiological Society of North America, Inc
https://read.qxmd.com/read/35399888/review-perspective-on-the-diagnosis-and-surgical-management-of-spinal-arachnoid-cysts
#37
REVIEW
Nancy E Epstein
BACKGROUND: Spinal arachnoid cysts (SAC) are typically congenital, spontaneous, traumatic (i.e., including iatrogenic/surgical), or inflammatory in origin. In descending order, they occur in the thoracic, lumbar, and cervical spine, and originate from focal entrapment of the arachnoid membrane. Arachnoid cysts represent 1-2% of all cystic spinal masses/tumors. The majority are extradural arachnoid cysts (EDAC) while 10% of all arachnoid cysts are intradural (IDAC) including subarachnoid, or extra-arachnoidal/subdural...
2022: Surgical Neurology International
https://read.qxmd.com/read/35397555/integrative-proteomic-characterization-of-trace-ffpe-samples-in-early-stage-gastrointestinal-cancer
#38
JOURNAL ARTICLE
Lingling Li, Hui Liu, Yan Li, Chunmei Guo, Bing Wang, Dan Shen, Qiao Zhang, Chen Ding
BACKGROUND: The surveillance and therapy of early-stage cancer would be better for patients' prognosis. However, the extreme trace amount of tissue samples in different stages have limited in portraying the characterization of early-stage cancer. Therefore, we focused on and presented comprehensive proteomic and phosphoproproteomic profiling of the trace FFPE samples from early-stage gastrointestinal cancer, and then explored the potential biomarkers of early-stage gastrointestinal cancer...
April 9, 2022: Proteome Science
https://read.qxmd.com/read/35133498/early-discharging-patients-with-chest-pain-using-edacs-adp-and-compass-mi-risk-predictors
#39
JOURNAL ARTICLE
Göksu Bozdereli Berikol, Hakan Aydın, Halil Doğan
Deciding on the early discharge of low-risk patients with chest pain is still controversial in emergency care. Beyond the validated tools for risk assessment, high sensitive troponin levels on admission, whether to take the next serial sampling or when to take are the main issues affecting the unnecessary follow-ups that lead to the emergency crowd. We aimed to investigate the prediction performance of emergency department assessment of chest pain score and accelerated diagnostic protocol (EDACS-ADP) and calculation of MI risk probabilities to manage patients with suspicion of myocardial infarction (COMPASS-MI)...
February 8, 2022: Heart and Vessels
https://read.qxmd.com/read/35103569/performance-of-prehospital-use-of-chest-pain-risk-stratification-tools-the-rescue-study
#40
JOURNAL ARTICLE
Jason P Stopyra, Anna C Snavely, Nicklaus P Ashburn, James O'Neill, Brennan E Paradee, Brian Hehl, Jordan Vorrie, Matthew Wells, R Darrell Nelson, Nella W Hendley, Chadwick D Miller, Simon A Mahler
BACKGROUND: Emergency medical services (EMS) assesses millions of patients with chest pain each year. However, tools validated to risk stratify patients for acute coronary syndrome (ACS) and pulmonary embolism (PE) have not been translated to the prehospital setting. The objective of this study is to assess the prehospital performance of risk stratification scores for 30-day major adverse cardiac events (MACE) and PE. METHODS: A prospective observational cohort study of patients ≥21 years of age with acute chest pain who were transported by EMS in two North Carolina (NC) counties was conducted from 18 April 2018-2 January 2019...
February 17, 2022: Prehospital Emergency Care
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