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https://www.readbyqxmd.com/read/28276586/the-eating-and-drinking-ability-classification-system-in-a-population-based-sample-of-preschool-children-with-cerebral-palsy
#1
Katherine A Benfer, Kelly A Weir, Kristie L Bell, Robert S Ware, Peter Sw Davies, Roslyn N Boyd
AIM: To determine (1) the reproducibility of the Eating and Drinking Ability Classification System (EDACS); (2) EDACS classification distribution in a population-based cohort with cerebral palsy (CP); and (3) the relationships between the EDACS and clinical mealtime assessment, other classifications, and health outcomes. METHOD: This was a cross-sectional population-based cohort study of 170 children with CP at 3 years to 5 years (mean 57.6mo, standard deviation [SD] 8...
March 9, 2017: Developmental Medicine and Child Neurology
https://www.readbyqxmd.com/read/28272743/functional-outcomes-in-children-and-young-people-with-dyskinetic-cerebral-palsy
#2
Elegast Monbaliu, Mary-Grace De La Peña, Els Ortibus, Guy Molenaers, Jan Deklerck, Hilde Feys
AIM: This cross-sectional study aimed to map the functional profile of individuals with dyskinetic cerebral palsy (CP), to determine interrelationships between the functional classification systems, and to investigate the relationship of functional abilities with dystonia and choreoathetosis severity. METHODS: Fifty-five children (<15y) and young people (15-22y) (30 males, 25 females; mean age 14y 6mo, standard deviation 4y 1mo) with dyskinetic CP were assessed using the Gross Motor Function Classification System (GMFCS), Manual Ability Classification System (MACS), Communication Function Classification System (CFCS), Eating and Drinking Ability Classification System (EDACS), and Viking Speech Scale (VSS), as well as the Dyskinesia Impairment Scale...
March 8, 2017: Developmental Medicine and Child Neurology
https://www.readbyqxmd.com/read/28270608/rab5-regulated-endocytosis-plays-a-crucial-role-in-apical-extrusion-of-transformed-cells
#3
Sayaka Saitoh, Takeshi Maruyama, Yuta Yako, Mihoko Kajita, Yoichiro Fujioka, Yusuke Ohba, Nobuhiro Kasai, Natsu Sugama, Shunsuke Kon, Susumu Ishikawa, Takashi Hayashi, Tomohiro Yamazaki, Masazumi Tada, Yasuyuki Fujita
Newly emerging transformed cells are often eliminated from epithelial tissues. Recent studies have revealed that this cancer-preventive process involves the interaction with the surrounding normal epithelial cells; however, the molecular mechanisms underlying this phenomenon remain largely unknown. In this study, using mammalian cell culture and zebrafish embryo systems, we have elucidated the functional involvement of endocytosis in the elimination of RasV12-transformed cells. First, we show that Rab5, a crucial regulator of endocytosis, is accumulated in RasV12-transformed cells that are surrounded by normal epithelial cells, which is accompanied by up-regulation of clathrin-dependent endocytosis...
March 7, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28246585/nanoparticle-linked-antagonist-for-leptin-signaling-inhibition-in-breast-cancer
#4
Tia Harmon, Adriana Harbuzariu, Viola Lanier, Crystal C Lipsey, Ward Kirlin, Lily Yang, Ruben R Gonzalez-Perez
AIM: To develop a leptin peptide receptor antagonist linked to nanoparticles and determine its effect on viability of breast cancer cells. METHODS: The leptin antagonist, LPrA2, was coupled via EDAC [1-Ethyl-3-(3-dimethylaminopropyl)carbodiimide] to iron oxide nanoparticles (IONP-LPrA2) to increase its efficacy. IONP-LPrA2 conjugation was confirmed by Western blot and nanoparticle tracking analysis. Human triple negative breast cancer (TNBC) MDA-MB-231, HCC1806 and estrogen receptor positive (ER(+)) MCF-7 cells were analyzed for the expression of the leptin receptor, Ob-R...
February 10, 2017: World Journal of Clinical Oncology
https://www.readbyqxmd.com/read/28157657/detecting-circulating-antibodies-by-controlled-surface-modification-with-specific-target-proteins-application-to-malaria
#5
Ana R Cardoso, Gustavo Cabral-Miranda, Arturo Reyes-Sandoval, Martin F Bachmann, M Goreti F Sales
Sensitive detection of specific antibodies by biosensors has become of major importance for monitoring and controlling epidemics. Here we report a development of a biosensor able to specifically measure antibodies in a drop of unmodified blood serum. Within minutes, the detection system measures presence of antibodies against Plasmodium vivax, a causing agent for malaria. The biosensor consists of a layer of carbon nanotubes (CNTs) which were casted on a carbon working electrode area of a three-electrode system and oxidized...
May 15, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/28108220/missed-myocardial-infarctions-in-ed-patients-prospectively-categorized-as-low-risk-by-established-risk-scores
#6
A J Singer, M P Than, S Smith, P McCullough, T W Barrett, R Birkhahn, M Reed, H C Thode, W D Arnold, L B Daniels, C de Filippi, G Headden, W F Peacock
STUDY OBJECTIVES: Few studies have prospectively compared multiple cardiac risk prediction scores. We compared the rate of missed acute myocardial infarction (AMI) in chest pain patients prospectively categorized as low risk by unstructured clinical impression, and by HEART, TIMI, GRACE, and EDACS scores, in combination with two negative contemporary cardiac troponins (cTn) available in the U.S. METHODS: We enrolled 434 patients with chest pain presenting to one of seven emergency departments (ED)...
January 5, 2017: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/28074723/-a-woman-with-excessive-dynamic-airway-collapse
#7
R L T N Salden, S Postma
BACKGROUND: 'Excessive dynamic airway collapse' (EDAC) is a form of tracheamalacia, that does not affect the rings of cartilage on the anterior side of the trachea, but in which the posterior wall of the trachea collapses during inspiration and expiration. CASE DESCRIPTION: An 80 year-old woman presented to the accident and emergency department with dyspnoea and severe inspiratory and expiratory stridor, with sudden onset a few hours previously. Following a series of investigations, she was shown to have a narrowing of the trachea, radiating from the posterior wall...
2017: Nederlands Tijdschrift Voor Geneeskunde
https://www.readbyqxmd.com/read/28005835/our-experience-on-silicone-y-stent-for-severe-copd-complicated-with-expiratory-central-airway-collapse
#8
Mehmet A Ozgul, Erdogan Cetinkaya, Mustafa Cortuk, Sinem Iliaz, Elif Tanriverdi, Sule Gul, Guler Ozgul, Hilal Onaran, Kenan Abbasli, Huseyin E Dincer
BACKGROUND: Expiratory central airway collapse (ECAC) is abnormal central airway narrowing during expiration. ECAC involves 2 different pathophysiological entities as tracheobronchomalacia and excessive dynamic airway collapse (EDAC). Although the exact cause is unknown, chronic obstructive pulmonary disease (COPD) is frequently accompanied by ECAC. Although there are various publications on the relationship between COPD and ECAC, there are very few data for stent placement in patients with tracheobronchomalacia accompanied severe COPD...
December 21, 2016: Journal of Bronchology & Interventional Pulmonology
https://www.readbyqxmd.com/read/27987786/comparison-of-glutaraldehyde-and-carbodiimides-to-crosslink-tissue-engineering-scaffolds-fabricated-by-decellularized-porcine-menisci
#9
Shuang Gao, Zhiguo Yuan, Weimin Guo, Mingxue Chen, Shuyun Liu, Tingfei Xi, Quanyi Guo
The objectives of this study were to fabricate porous scaffolds using decellularized meniscus, and to explore a preferable crosslinking condition to enhance mechanical properties of scaffolds. Moreover, the microstructure, porosity, biodegradation and cytotoxicity were also evaluated. EDAC or GTA in different concentration was used to crosslink scaffolds. FTIR demonstrated functional groups change in crosslinking process. SEM photography showed that crosslinked scaffolds had blurry edges, which resulted scaffolds crosslinked by 1...
February 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/27984825/colloid-adhesive-and-release-properties-of-nanoparticular-ternary-complexes-between-cationic-and-anionic-polysaccharides-and-basic-proteins-like-bone-morphogenetic-protein-bmp-2
#10
R Petzold, D Vehlow, B Urban, A L Grab, E A Cavalcanti-Adam, V Alt, M Müller
Herein we describe an interfacial local drug delivery system for bone morphogenetic protein 2 (BMP-2) based on coatings of polyelectrolyte complex (PEC) nanoparticles (NP). The application horizon is the functionalization of bone substituting materials (BSM) used for the therapy of systemic bone diseases. Nanoparticular ternary complexes of cationic and anionic polysaccharides and BMP-2 or two further model proteins, respectively, were prepared in dependence of the molar mixing ratio, pH value and of the cationic polysaccharide...
November 24, 2016: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/27735070/in-vitro-evaluation-of-an-alternative-neonatal-extracorporeal-life-support-circuit-on-hemodynamic-performance-and-bubble-trap
#11
Shannon B Spencer, Shigang Wang, Karl Woitas, Kristen Glass, Allen R Kunselman, Akif Ündar
The objective of this study was to evaluate an alternative neonatal extracorporeal life support (ECLS) circuit with a RotaFlow centrifugal pump and Better-Bladder (BB) for hemodynamic performance and gaseous microemboli (GME) capture in a simulated neonatal ECLS system. The circuit consisted of a Maquet RotaFlow centrifugal pump, a Quadrox-iD Pediatric diffusion membrane oxygenator, 8 Fr arterial cannula, and 10 Fr venous cannula. A "Y" connector was inserted into the venous line to allow for comparison between BB and no BB...
January 2017: Artificial Organs
https://www.readbyqxmd.com/read/27729706/effect-of-normobaric-versus-hypobaric-oxygenation-on-gaseous-microemboli-removal-in-a-diffusion-membrane-oxygenator-an-in-vitro-comparison
#12
Matthew Schuldes, Jeffrey B Riley, Stephen G Francis, Sean Clingan
Gaseous microemboli (GME) are an abnormal physiological occurrence during cardiopulmonary bypass and extracorporeal membrane oxygenation (ECMO). Several studies have correlated negative sequelae with exposure to increased amounts of GME. Hypobaric oxygenation is effective at eliminating GME in hollow-fiber microporous membrane oxygenators. However, hollow-fiber diffusion membrane oxygenators, which are commonly used for ECMO, have yet to be validated. The purpose of this study was to determine if hypobaric oxygenation, compared against normobaric oxygenation, can reduce introduced GME when used on diffusion membrane oxygenators...
September 2016: Journal of Extra-corporeal Technology
https://www.readbyqxmd.com/read/27578929/tracheobronchomalacia-excessive-dynamic-airway-collapse-in-patients-with-chronic-obstructive-pulmonary-disease-with-persistent-expiratory-wheeze-a-pilot-study
#13
Girish Sindhwani, Rakhee Sodhi, Manju Saini, Varuna Jethani, Sushant Khanduri, Baltej Singh
BACKGROUND: Tracheobronchomalacia (TBM) refers to a condition in which structural integrity of cartilaginous wall of trachea is lost. Excessive dynamic airway collapse (EDAC) is characterized by excessive invagination of posterior wall of trachea. In both these conditions, airway lumen gets compromised, especially during expiration, which can lead to symptoms such as breathlessness, cough, and wheezing. Both these conditions can be present in obstructive lung diseases; TBM due to chronic airway inflammation and EDAC due to dynamic compressive forces during expiration...
July 2016: Lung India: Official Organ of Indian Chest Society
https://www.readbyqxmd.com/read/27469348/review-article-diagnostic-accuracy-of-risk-stratification-tools-for-patients-with-chest-pain-in-the-rural-emergency-department-a-systematic-review
#14
REVIEW
Tina Roche, Natasha Jennings, Stuart Clifford, Jane O'connell, Matthew Lutze, Edward Gosden, N Fionna Hadden, Glenn Gardner
Risk stratification tools for patients presenting to rural EDs with undifferentiated chest pain enable early definitive treatment in high-risk patients. This systematic review compares the most commonly used risk stratification tools used to predict the risk of major adverse cardiac event (MACE) for patients presenting to rural EDs with chest pain. A comprehensive search of MEDLINE and Embase for studies published between January 2011 and January 2015 was undertaken. Study quality was assessed using QUADAS-2 criteria and the PRISMA guidelines...
October 2016: Emergency Medicine Australasia: EMA
https://www.readbyqxmd.com/read/27406833/external-validation-of-the-emergency-department-assessment-of-chest-pain-score-accelerated-diagnostic-pathway-edacs-adp
#15
Dylan Flaws, Martin Than, Frank Xavier Scheuermeyer, James Christenson, Barbara Boychuk, Jaimi H Greenslade, Sally Aldous, Christopher J Hammett, William A Parsonage, Joanne M Deely, John W Pickering, Louise Cullen
OBJECTIVE: The emergency department assessment of chest pain score accelerated diagnostic pathway (EDACS-ADP) facilitates low-risk ED chest pain patients early to outpatient investigation. We aimed to validate this rule in a North American population. METHODS: We performed a retrospective validation of the EDACS-ADP using 763 chest pain patients who presented to St Paul's Hospital, Vancouver, Canada, between June 2000 and January 2003. Patients were classified as low risk if they had an EDACS <16, no new ischaemia on ECG and non-elevated serial 0-hour and 2-hour cardiac troponin concentrations...
September 2016: Emergency Medicine Journal: EMJ
https://www.readbyqxmd.com/read/27237407/surgical-treatment-of-tracheobronchomalacia-a-novel-approach
#16
REVIEW
Sigrid Bairdain, David Zurakowski, Christopher W Baird, Russell W Jennings
Tracheobronchomalacia, as a whole, is likely misdiagnosed and underestimated as a cause of respiratory compromise in pediatric patients. Currently, there is no standardized approach for the overall evaluation of pediatric tracheobronchomalacia (TBM) and the concept of excessive dynamic airway collapse (EDAC); no grading score for the evaluation of severity; nor a standardized means to successfully approach TBM and EDAC. This paper describes our experience standardizing the approach to these complex patients whose backgrounds include different disease etiologies, as well as a variety of comorbid conditions...
June 2016: Paediatric Respiratory Reviews
https://www.readbyqxmd.com/read/27221930/formulation-and-cytotoxicity-of-ribosome-inactivating-protein-mirabilis-jalapa-l-nanoparticles-using-alginate-low-viscosity-chitosan-conjugated-with-anti-epcam-antibodies-in-the-t47d-breast-cancer-cell-line
#17
Psycha Anindya Wicaksono, Sismindari Name, Ronny Martien, Hilda Ismail
Ribosome-inactivating protein (RIP) from Mirabilis jalapa L. leaves has cytotoxic effects on breast cancer cell lines but is less toxic towards normal cells. However, it can easily be degraded after administration so it needs to be formulated into nanoparticles to increase its resistance to enzymatic degradation. The objectives of this study were to develop a protein extract of M. jalapa L. leaves (RIP-MJ) incorporated into nanoparticles conjugated with Anti-EpCAM antibodies, and to determine its cytotoxicity and selectivity in the T47D breast cancer cell line...
2016: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/27134302/arterial-limb-microemboli-during-cardiopulmonary-bypass-observations-from-a-congenital-cardiac-surgery-practice
#18
Gregory S Matte, Kevin R Connor, Hua Liu, James A DiNardo, David Faraoni, Frank Pigula
Gaseous microemboli (GME) are known to be delivered to the arterial circulation of patients during cardiopulmonary bypass (CPB). An increased number of GME delivered during adult CPB has been associated with brain injury and postoperative cognitive dysfunction. The GME load in children exposed to CPB and its consequences are not well characterized. We sought to establish a baseline of arterial limb emboli counts during the conduct of CPB for our population of patients requiring surgery for congenital heart disease...
March 2016: Journal of Extra-corporeal Technology
https://www.readbyqxmd.com/read/27059732/time-courses-and-value-of-circulating-microparticles-in-patients-with-operable-stage-non-small-cell-lung-cancer-undergoing-surgical-intervention
#19
Chia-Cheng Tseng, Chin-Chou Wang, Chang-Chun Hsiao, Hung-I Lu, Steve Leu, Huang-Chih Chang, Kuo-Tung Huang, Wen-Feng Fang, Yu-Mu Chen, Shih-Feng Liu, Cheng-Ta Yang, Meng-Chih Lin, Hon-Kan Yip
Microparticles (MPs) are substantially increased in patients with operable stage non-small cell lung cancer (NSCLC) prior to lung resection surgery. This study tested the hypothesis that there is a decrease in MPs after surgical intervention. Between March 2012 and January 2015, 33 patients who had operable stage NSCLC were consecutively and prospectively enrolled into the study. Additionally, 31 healthy subjects who were consecutively enrolled in the study period served as age- and gender-matched controls...
September 2016: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/27021241/all-solid-state-high-performance-asymmetric-supercapacitors-based-on-novel-mns-nanocrystal-and-activated-carbon-materials
#20
Teng Chen, Yongfu Tang, Yuqing Qiao, Zhangyu Liu, Wenfeng Guo, Jianzheng Song, Shichun Mu, Shengxue Yu, Yufeng Zhao, Faming Gao
All-solid-state high-performance asymmetric supercapacitors (ASCs) are fabricated using γ-MnS as positive electrode and porous eggplant derived activated carbon (EDAC) as negative electrode with saturated potassium hydroxide agar gel as the solid electrolyte. The laminar wurtzite nanostructure of γ-MnS facilitates the insertion of hydroxyl ions into the interlayer space, and the manganese sulfide nanowire offers electronic transportation channels. The size-uniform porous nanostructure of EDAC provides a continuous electron pathway as well as facilitates short ionic transportation pathways...
March 29, 2016: Scientific Reports
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