keyword
https://read.qxmd.com/read/36766790/effects-of-fatty-acid-metabolites-on-adipocytes-britening-role-of-thromboxane-a2
#21
JOURNAL ARTICLE
Cécilia Colson, Pierre-Louis Batrow, Sebastian Dieckmann, Laura Contu, Christian H Roux, Laurence Balas, Claire Vigor, Baptiste Fourmaux, Nadine Gautier, Nathalie Rochet, Nathalie Bernoud-Hubac, Thierry Durand, Dominique Langin, Martin Klingenspor, Ez-Zoubir Amri
Obesity is a complex disease highly related to diet and lifestyle and is associated with low amount of thermogenic adipocytes. Therapeutics that regulate brown adipocyte recruitment and activity represent interesting strategies to fight overweight and associated comorbidities. Recent studies suggest a role for several fatty acids and their metabolites, called lipokines, in the control of thermogenesis. The purpose of this work was to analyze the role of several lipokines in the control of brown/brite adipocyte formation...
January 30, 2023: Cells
https://read.qxmd.com/read/36680167/development-and-validation-of-a-rapid-screening-test-for-htlv-i-igg-antibodies
#22
JOURNAL ARTICLE
Bobby Brooke Herrera, Rafaela Mayoral, Carlos Brites
Initial diagnosis of human T cell lymphotropic virus (HTLV) infections is mainly based by detecting antibodies in plasma or serum using laboratory-based methods. The aim of this study was to develop and evaluate a rapid screening test for HTLV-I antibodies. Our rapid screening test uses HTLV-I p24 antigen conjugated to gold nanoparticles and an anti-human IgG antibody immobilized to a nitrocellulose strip to detect human HTLV-I p24-specific IgG antibodies via immunochromatography. Performance of the rapid screening test for HTLV-I was conducted on a total of 118 serum specimens collected in Salvador, Bahia, the epicenter for HTLV-1 infection in Brazil...
December 31, 2022: Viruses
https://read.qxmd.com/read/36359774/emerging-role-of-mir-21-5p-in-neuron-glia-dysregulation-and-exosome-transfer-using-multiple-models-of-alzheimer-s-disease
#23
JOURNAL ARTICLE
Gonçalo Garcia, Sara Pinto, Sofia Ferreira, Daniela Lopes, Maria João Serrador, Adelaide Fernandes, Ana Rita Vaz, Alexandre de Mendonça, Frank Edenhofer, Tarja Malm, Jari Koistinaho, Dora Brites
Alzheimer's disease (AD) is a neurodegenerative disorder associated with neuron-glia dysfunction and dysregulated miRNAs. We previously reported upregulated miR-124/miR-21 in AD neurons and their exosomes. However, their glial distribution, phenotypic alterations and exosomal spread are scarcely documented. Here, we show glial cell activation and miR-21 overexpression in mouse organotypic hippocampal slices transplanted with SH-SY5Y cells expressing the human APP695 Swedish mutation. The upregulation of miR-21 only in the CSF from a small series of mild cognitive impairment (MCI) AD patients, but not in non-AD MCI individuals, supports its discriminatory potential...
October 26, 2022: Cells
https://read.qxmd.com/read/36272998/bile-acids-profile-and-redox-status-in-healthy-infants
#24
JOURNAL ARTICLE
Ermelinda Santos Silva, Susana Rocha, Rita Candeias Ramos, Helena Coutinho, Cristina Catarino, Fernanda Teixeira, Graça Henriques, Ana Isabel Lopes, Alice Santos-Silva, Dora Brites
BACKGROUND: At birth, human neonates are more likely to develop cholestasis and oxidative stress due to immaturity or other causes. We aimed to search for a potential association between bile acids profile, redox status, and type of diet in healthy infants. METHODS: A cross-sectional, exploratory study enrolled 2-month-old full-term infants (n = 32). We measured plasma bile acids (total and conjugated), and red blood cell (RBC) oxidative stress biomarkers. The type of diet (breastfeeding, mixed, formula) was used as an independent variable...
October 22, 2022: Pediatric Research
https://read.qxmd.com/read/36140218/intrathecal-injection-of-the-secretome-from-als-motor-neurons-regulated-for-mir-124-expression-prevents-disease-outcomes-in-sod1-g93a-mice
#25
JOURNAL ARTICLE
Marta Barbosa, Marta Santos, Nídia de Sousa, Sara Duarte-Silva, Ana Rita Vaz, António J Salgado, Dora Brites
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease with short life expectancy and no effective therapy. We previously identified upregulated miR-124 in NSC-34-motor neurons (MNs) expressing human SOD1-G93A (mSOD1) and established its implication in mSOD1 MN degeneration and glial cell activation. When anti-miR-124-treated mSOD1 MN (preconditioned) secretome was incubated in spinal cord organotypic cultures from symptomatic mSOD1 mice, the dysregulated homeostatic balance was circumvented. To decipher the therapeutic potential of such preconditioned secretome, we intrathecally injected it in mSOD1 mice at the early stage of the disease (12-week-old)...
August 29, 2022: Biomedicines
https://read.qxmd.com/read/36107478/a-neurogenic-signature-involving-monoamine-oxidase-a-controls-human-thermogenic-adipose-tissue-development
#26
JOURNAL ARTICLE
Javier Solivan-Rivera, Zinger Yang Loureiro, Tiffany DeSouza, Anand Desai, Sabine Pallat, Qin Yang, Raziel Rojas-Rodriguez, Rachel Ziegler, Pantos Skritakis, Shannon Joyce, Denise Zhong, Tammy Nguyen, Silvia Corvera
Mechanisms that control 'beige/brite' thermogenic adipose tissue development may be harnessed to improve human metabolic health. To define these mechanisms, we developed a species-hybrid model in which human mesenchymal progenitor cells were used to develop white or thermogenic/beige adipose tissue in mice. The hybrid adipose tissue developed distinctive features of human adipose tissue, such as larger adipocyte size, despite its neurovascular architecture being entirely of murine origin. Thermogenic adipose tissue recruited a denser, qualitatively distinct vascular network, differing in genes mapping to circadian rhythm pathways, and denser sympathetic innervation...
September 15, 2022: ELife
https://read.qxmd.com/read/36068578/browning-of-the-white-adipose-tissue-regulation-new-insights-into-nutritional-and-metabolic-relevance-in-health-and-diseases
#27
REVIEW
Sabrina Azevedo Machado, Gabriel Pasquarelli-do-Nascimento, Debora Santos da Silva, Gabriel Ribeiro Farias, Igor de Oliveira Santos, Luana Borges Baptista, Kelly Grace Magalhães
Adipose tissues are dynamic tissues that play crucial physiological roles in maintaining health and homeostasis. Although white adipose tissue and brown adipose tissue are currently considered key endocrine organs, they differ functionally and morphologically. The existence of the beige or brite adipocytes, cells displaying intermediary characteristics between white and brown adipocytes, illustrates the plastic nature of the adipose tissue. These cells are generated through white adipose tissue browning, a process associated with augmented non-shivering thermogenesis and metabolic capacity...
September 6, 2022: Nutrition & Metabolism
https://read.qxmd.com/read/35946625/work-ability-and-associated-factors-in-people-living-with-human-t-cell-leukemia-virus-type-1
#28
JOURNAL ARTICLE
Dayana Alves Costa, Fernando Martins Carvalho, Nicolle Melo Vieira, Gleicy Gabriela Spínola Carneiro Falcão, Viviane Almeida Sarmento, Carlos Brites, Liliane Lins-Kusterer
BACKGROUND: Infection with the human T-lymphotropic virus type 1 (HTLV-1) affects an estimated 10-15 million people worldwide. However, knowledge of the impact of HTLV-1 infection on work ability is lacking. This study aimed to measure the frequency and identify factors associated with poor work ability in patients living with HTLV-1. METHODS: This cross-sectional study included 207 individuals infected with HTLV-1 who attended the University Hospital in Salvador, Bahia, Brazil...
2022: Revista da Sociedade Brasileira de Medicina Tropical
https://read.qxmd.com/read/35846747/oral-gut-microbiome-analysis-in-patients-with-metabolic-associated-fatty-liver-disease-having-different-tongue-image-feature
#29
JOURNAL ARTICLE
Chenxia Lu, Hui Zhu, Dan Zhao, Jia Zhang, Kai Yang, Yi Lv, Miao Peng, Xi Xu, Jingjing Huang, Zuoyu Shao, Mingzhong Xiao, Xiaodong Li
OBJECTIVE: The objective of this study was to identify the biological correlation between the tongue coating color and oral and gut micro-characteristics in metabolic-associated fatty liver disease (MAFLD) patients. METHOD: The characteristics of the tongue coating were examined using an automatic tongue diagnosis system. Tongue coating and stool samples were collected from 38 MAFLD patients, and 16S rDNA full-length assembly sequencing technology (16S-FAST) was used for bioinformatic analysis...
2022: Frontiers in Cellular and Infection Microbiology
https://read.qxmd.com/read/35793314/neurons-contribute-to-pathology-in-a-mouse-model-of-krabbe-disease-in-a-cell-autonomous-manner
#30
COMMENT
Pedro Brites, Monica M Sousa
In this issue of PLOS Biology, Kreher and colleagues show in a mouse model that in vivo, neurons and not only myelinating glia are primary effectors of disease progression in Krabbe disease. The neuron-specific model generated allows the unprecedented capacity to investigate the neuronal autonomous component of this disorder.
July 2022: PLoS Biology
https://read.qxmd.com/read/35646839/silk-hydrogel-mediated-delivery-of-bone-morphogenetic-protein-7-directly-to-subcutaneous-white-adipose-tissue-increases-browning-and-energy-expenditure
#31
JOURNAL ARTICLE
Kristy L Townsend, Eleanor Pritchard, Jeannine M Coburn, Young Mi Kwon, Magdalena Blaszkiewicz, Matthew D Lynes, David L Kaplan, Yu-Hua Tseng
Objective: Increasing the mass and/or activity of brown adipose tissue (BAT) is one promising avenue for treating obesity and related metabolic conditions, given that BAT has a high potential for energy expenditure and is capable of improving glucose and lipid homeostasis. BAT occurs either in discrete "classical" depots, or interspersed in white adipose tissue (WAT), termed "inducible/recruitable" BAT, or 'beige/brite' adipocytes. We and others have demonstrated that bone morphogenetic protein 7 (BMP7) induces brown adipogenesis in committed and uncommitted progenitor cells, resulting in increased energy expenditure and reduced weight gain in mice...
2022: Frontiers in Bioengineering and Biotechnology
https://read.qxmd.com/read/35620289/protective-signature-of-ifn%C3%AE-stimulated-microglia-relies-on-mir-124-3p-regulation-from-the-secretome-released-by-mutant-app-swedish-neuronal-cells
#32
JOURNAL ARTICLE
Gonçalo Garcia, Adelaide Fernandes, Frank Stein, Dora Brites
Microglia-associated inflammation and miRNA dysregulation are key players in Alzheimer's disease (AD) pathophysiology. Previously, we showed miR-124 upregulation in APP Swedish SH-SY5Y (SWE) and PSEN1 iPSC-derived neurons and its propagation by the secretome (soluble and exosomal fractions). After modulation with miR-124 mimic/inhibitor, we identified common responsive mechanisms between such models. We also reported miR-124 colocalization with microglia in AD patient hippocampi. Herein, we determined how miR-124 modulation in SWE cells influences microglia polarized subtypes in the context of inflammation...
2022: Frontiers in Pharmacology
https://read.qxmd.com/read/35620168/s100b-inhibition-protects-from-chronic-experimental-autoimmune-encephalomyelitis
#33
JOURNAL ARTICLE
Catarina Barros, Andreia Barateiro, Alexandre Neto, Beatriz Soromenho, Afonso P Basto, Joana M Mateus, Sara Xapelli, Ana M Sebastião, Dora Brites, Luís Graça, Adelaide Fernandes
Studies have correlated excessive S100B, a small inflammatory molecule, with demyelination and associated inflammatory processes occurring in multiple sclerosis. The relevance of S100B in multiple sclerosis pathology brought an emerging curiosity highlighting its use as a potential therapeutic target to reduce damage during the multiple sclerosis course, namely during inflammatory relapses. We examined the relevance of S100B and further investigated the potential of S100B-neutralizing small-molecule pentamidine in chronic experimental autoimmune encephalomyelitis...
2022: Brain communications
https://read.qxmd.com/read/35613667/insights-into-structure-and-function-of-cdcvegfs-the-vascular-endothelial-growth-factor-from-crotalus-durissus-collilineatus-snake-venom
#34
JOURNAL ARTICLE
Isabela Gobbo Ferreira, Manuela Berto Pucca, Iara Aimê Cardoso, Karla de Castro Figueiredo Bordon, Gisele Adriano Wiezel, Fernanda Gobbi Amorim, Renata Santos Rodrigues, Veridiana de Melo Rodrigues, Vera Lucia de Campos Brites, José César Rosa, Daiana Silva Lopes, Eliane Candiani Arantes
Vascular endothelial growth factors (VEGFs) are crucial molecules involved in the modulation of angiogenesis. Snake venom-derived VEGFs (svVEGFs) are known to contribute significantly to the envenoming due to their capacity of increasing vascular permeability. In our work, we isolated and analyzed the biochemical and functional properties of the VEGF from Crotalus durissus collilineatus venom (CdcVEGF). The venom was fractionated by reversed phase chromatography on FPLC system (Fast Protein Liquid Chromatography) and the eluted fractions were submitted to an ELISA assay using an anti-VEGF-F antibody, for identification of svVEGF...
September 2022: Biochimie
https://read.qxmd.com/read/35572112/ring-fused-meso-tetraarylchlorins-as-auspicious-pdt-sensitizers-synthesis-structural-characterization-photophysics-and-biological-evaluation
#35
JOURNAL ARTICLE
Mafalda Laranjo, Nelson A M Pereira, Andreia S R Oliveira, Márcia Campos Aguiar, Gonçalo Brites, Bruno F O Nascimento, Beatriz Serambeque, Bruna D P Costa, João Pina, J Sérgio Seixas de Melo, Marta Pineiro, M Filomena Botelho, Teresa M V D Pinho E Melo
Novel 4,5,6,7-tetrahydropyrazolo[1,5- a ]pyridine-fused meso -tetraarylchlorins, with different degrees of hydrophilicity (with methyl ester, hydroxymethyl, and carboxylic acid moieties), have been synthesized and their photophysical characterization as well as in vitro photocytotoxicity assessment against human melanoma and esophageal and bladder carcinomas was carried out. An integrated analysis of the photosensitizers' performance, considering the singlet oxygen generation data, cell internalization, and intracellular localization, allowed to establish relevant structure-photoactivity relationships and the rationalization of the observed photocytotoxicity...
2022: Frontiers in Chemistry
https://read.qxmd.com/read/35435746/genital-cytokines-in-hiv-human-papillomavirus-co-infection-a-systematic-review
#36
JOURNAL ARTICLE
Sandra Schindler, Rodrigo Almeida Magalhães, Esther Louise Freire Costa, Carlos Brites
BACKGROUND: Cervical cancer is the fourth cancer in incidence and the third mortality among women worldwide. Women living with HIV have a significantly increased risk of cervical cancer. The immune response of the host is crucial to determine the course of the HPV infection and cytokines play an important role modulating viral multiplication and concentrating the immune response in the Th1 or Th2 pattern. The aim of the present study is to evaluate the available evidence on the concentration of genital cytokines and their role in HPV infection in HIV-infected women...
April 18, 2022: AIDS Research and Human Retroviruses
https://read.qxmd.com/read/35422699/challenges-in-the-development-of-drug-delivery-systems-based-on-small-extracellular-vesicles-for-therapy-of-brain-diseases
#37
REVIEW
Gecioni Loch-Neckel, Ana Teresa Matos, Ana Rita Vaz, Dora Brites
Small extracellular vesicles (sEVs) have ∼30-200 nm diameter size and may act as carriers of different cargoes, depending on the cell of origin or on the physiological/pathological condition. As endogenous nanovesicles, sEVs are important in intercellular communication and have many of the desirable features of an ideal drug delivery system. sEVs are naturally biocompatible, with superior targeting capability, safety profile, nanometric size, and can be loaded with both lipophilic and hydrophilic agents...
2022: Frontiers in Pharmacology
https://read.qxmd.com/read/35406750/neurotoxic-astrocytes-directly-converted-from-sporadic-and-familial-als-patient-fibroblasts-reveal-signature-diversities-and-mir-146a-theragnostic-potential-in-specific-subtypes
#38
JOURNAL ARTICLE
Cátia Gomes, Catarina Sequeira, Shibi Likhite, Cassandra N Dennys, Stephen J Kolb, Pamela J Shaw, Ana R Vaz, Brian K Kaspar, Kathrin Meyer, Dora Brites
A lack of stratification methods in patients with amyotrophic lateral sclerosis (ALS) is likely implicated in therapeutic failures. Regional diversities and pathophysiological abnormalities in astrocytes from mice with SOD1 mutations (mSOD1-ALS) can now be explored in human patients using somatic cell reprogramming. Here, fibroblasts from four sporadic (sALS) and three mSOD1-ALS patients were transdifferentiated into induced astrocytes (iAstrocytes). ALS iAstrocytes were neurotoxic toward HB9-GFP mouse motor neurons (MNs) and exhibited subtype stratification through GFAP, CX43, Ki-67, miR-155 and miR-146a expression levels...
April 1, 2022: Cells
https://read.qxmd.com/read/35359787/clinical-and-laboratory-outcomes-in-hiv-1-and-htlv-1-2-coinfection-a-systematic-review
#39
Iris Montaño-Castellón, Cleyde Sheyla Chachaqui Marconi, Clara Saffe, Carlos Brites
Aim: To perform a systematic review to describe the available findings on clinical outcomes in HIV-1 and HTLV-1/HTLV-2 co-infected individuals since 1995. Design: This Systematic Review used PECO criteria follow by PRISMA reporting guidelines and registered as CRD42021279062 (Prospero database). The Newcastle-Ottawa Scale assessed the methodological quality of included studies. Data Collection and Analysis: A systematical search in PubMed/MEDLINE, Embase, Web of Sciences databases for cross-sectional, case-control, or cohort studies design to identify clinical and laboratorial outcomes related to HIV-1 and HTLV-1/2 coinfection...
2022: Frontiers in Public Health
https://read.qxmd.com/read/35335937/chemical-composition-and-effect-against-skin-alterations-of-bioactive-extracts-obtained-by-the-hydrodistillation-of-eucalyptus-globulus-leaves
#40
JOURNAL ARTICLE
Patrícia Moreira, Fábio Jesus Sousa, Patrícia Matos, Gonçalo Sousa Brites, Maria José Gonçalves, Carlos Cavaleiro, Artur Figueirinha, Lígia Salgueiro, Maria Teresa Batista, Pedro Costa Branco, Maria Teresa Cruz, Cláudia Fragão Pereira
Eucalyptus globulus is planted extensively for pulp, paper and wood production. Although bioactive compounds obtained from its biomass are used as cosmetics ingredients, the skin effects were not yet fully explored. In order to fill this gap, this work aimed to study the protective effect against skin damage provided by the essential oil (EO) obtained from the hydrodistillation of Eucalyptus globulus leaves, and by an extract obtained from the hydrodistillation residual water (HRW). The major compound identified in the EO was 1,8-Cineole, and the phenolic acids in the HRW included gallic acid as the main phenolic constituent...
March 3, 2022: Pharmaceutics
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