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Agnieszka Skorko, Matthew Thomas, Andrew Mumford, Thomas Johnson, Elinor Griffiths, Rosemary Greenwood, Jonathan Benger
INTRODUCTION: Out-of-hospital cardiac arrest (OHCA) has an annual incidence of approximately 60 000 in the UK. Less than 10% of those who receive resuscitation survive to hospital discharge. For OHCA of a presumed cardiac cause, the optimal antiplatelet therapy is currently unknown. Previous studies indicate that a procoagulopathic state exists postcardiac arrest which may contribute to the formation of thrombi and contribute to poor outcomes. However, the administration of antiplatelet therapies needs to be balanced against the increased risk of bleeding that these individuals face...
July 10, 2017: BMJ Open
Matthew Wilson, Anne V Grossestreuer, David F Gaieski, Benjamin S Abella, William Frohna, Munish Goyal
OBJECTIVE: With the demonstrated benefit of an early-invasive strategy for STEMI and VF/VT arrest patients, there is interest in assessing the potential benefit of early angiography for non-shockable (PEA/Asystole) arrest patients. We hypothesized that in cardiac arrest patients who obtain return of spontaneous circulation (ROSC) after a non-shockable initial rhythm and do not have STEMI the incidence of coronary intervention would be clinically insignificant (<5%). METHODS: Retrospective multicenter US clinical registry study of post-cardiac arrest patients at 18 hospitals between 1/00 and 5/14...
April 2017: Resuscitation
Kathrine Ekström, Morten Dalsgaard, Kasper Iversen, Ulrik Pedersen-Bjergaard, Niels Vejlstrup, Sarah Seberg Diemar, Manja Idorn, Birger Thorsteinsson, Thomas Engstrøm
OBJECTIVES: Acute STEMI is routinely treated by acute PCI. This treatment may itself damage the tissue (reperfusion injury). Conditioning with GLP-1 analogs has been shown to reduce reperfusion injury. Likewise, ischemic postconditioning provides cardioprotection following STEMI. We tested if combined conditioning with the GLP-1 analog liraglutide and ischemic postconditioning offered additive cardioprotective effect after reperfusion of 45 min coronary occlusion of left anterior descending artery (LAD)...
February 2017: Scandinavian Cardiovascular Journal: SCJ
Aleksander Zeliaś, Janina Stępińska, Janusz Andres, Aleksander Trąbka-Zawicki, Jerzy Sadowski, Krzysztof Żmudka
BACKGROUND AND AIM: The aim of the study was to evaluate survival and neurological function of out-of-hospital cardiac arrest (OHCA) patients admitted for urgent coronary angiography (UCA) with a view to percutaneous coronary intervention (PCI). METHODS: Hospital records of OHCA patients admitted to an invasive cardiology centre (providing 24 h a day/7 days a week service) in 2000-2010 were reviewed retrospectively, and similar data collected in 2011 were reviewed prospectively...
2014: Kardiologia Polska
Mahmoud Ahmed, Arabi Abdul
PATIENT: Male, 47 FINAL DIAGNOSIS: Acute myocardial infarction Symptoms: Chest pain Medication: - Clinical Procedure: - Specialty: Cardiology. OBJECTIVE: Unusual clinical course. BACKGROUND: Double myocardial infarction involving two culprit major vessels is a rarely reported presentation with high incidence of mortality. CASE REPORT: In this study, we report 47-year-old male patient who had an attack of chest pain associated with ST-segment elevation in the antero-lateral leads...
2013: American Journal of Case Reports
Vecih Oduncu, Ayhan Erkol, Ali Cevat Tanalp, Cevat Kırma, Mustafa Bulut, Atila Bitigen, Selçuk Pala, Kürşat Tigen, Ali M Esen
OBJECTIVES: We aimed to compare the efficacy of primary percutaneous coronary intervention (p-PCI) in patients >=80 versus <80 years of age with ST-segment elevation myocardial infarction (STEMI). STUDY DESIGN: We retrospectively enrolled 2213 patients with acute STEMI. The patients were prospectively followed up for a median of 42 months. Early and late clinical outcomes were compared according to age. RESULTS: One-hundred and seventy-nine (8...
June 2013: Türk Kardiyoloji Derneği Arşivi: Türk Kardiyoloji Derneğinin Yayın Organıdır
Mukesh Singh, Tejaskumar Shah, Kavia Khosla, Param Singh, Janos Molnar, Sandeep Khosla, Rohit Arora
BACKGROUND: Studies evaluating intracoronary administration of adenosine for prevention of microvascular dysfunction and ischemic-reperfusion injury in patients with acute myocardial infarction (AMI) undergoing primary percutaneous coronary intervention (PCI) have yielded mixed results. Therefore, we performed a meta-analysis of these trials to evaluate the safety and efficacy of intracoronary adenosine administration in patients with AMI undergoing primary PCI. METHODS: A total of seven prospective randomized controlled trials were analyzed...
June 2012: Therapeutic Advances in Cardiovascular Disease
Kaoru Okishige, Shigetaka Kanda, Tsukasa Shimura, Manabu Kurabayashi, Daisuke Ueshima, Naoyuki Miwa, Koji Sugiyama, Hideshi Aoyagi, Koujirou Yoshimura, Hidekiyo Yanagi, Koji Azegami
BACKGROUND: Ischemic "pre"-conditioning has been shown to have antiarrhythmic effects. The aim of this study was to investigate whether ischemic "post"-conditioning (post-CON) also has antiarrhythmic effects in ST-segment elevation myocardial infarction (STEMI) patients undergoing coronary angioplasty (PCI) as a clinical model of post-CON. METHODS AND RESULTS: A total of 61 patients suffering from an acute myocardial infarction (AMI) were included. The QT dispersion (QTd) was measured before each balloon inflation (BI) and after deflation (BD) during PCI...
September 2011: Journal of Cardiology
Shingo Hori
Key changes in Guideline 2010 by Japanese Resuscitation Council were described and the reasons of the change were explained based on 2010 International Consensus on Cardiopulmonary Resuscitation and Emergency Cardiovascular Care with Treatment Recommendations. In BLS, the value of chest compression was further emphasized and it became an initial skill of CPR In ALS, post resuscitation care was systemized by incorporating hypothermia, PCI, and other diagnostic and therapeutic modalities. Indication of hypothermia was further expanded to non-VF categories...
April 2011: Nihon Rinsho. Japanese Journal of Clinical Medicine
Choichiro Tase, Yuko Ohno, Arifumi Hasegawa, Yasuhiko Tsukada, Jiro Shimada, Yukihiro Ikegami, Nobuo Sakamoto, Yasuchika Takeishi
In the case of acute myocardial infarction (AMI), prompt and appropriate initial treatment is essential for increasing the rate of survival and early reperfusion is a main determinant factor for long-term prognosis. The survival of a patient with refractory ventricular fibrillation was made possible by cooperative emergency medical care including air medical transport, despite long distance to the hospital. The patient was a 60-year-old man. Under a diagnosis of AMI, a helicopter emergency medical service (HEMS) with medical staff on board was requested...
December 2010: Fukushima Journal of Medical Science
R Sýkora, R Janda
INTRODUCTION AND AIMS: Therapeutic hypothermia is a standard part of post-resuscitation care. Here we present cohort patients after non-traumatic cardiac arrest and their neurological outcomes who underwent 12 hours of therapeutic hypothermia. Moreover, we focused on examining the results of particular subgroup of patients with initial ventricular fibrillation (VF) with acute myocardial infarction with ST-elevation (STEMI) who underwent coronary intervention (PCI). METHODS: We evaluated retrospectively the patients with non-traumatic out-of- and in-hospital cardiac arrest (IHCA, OHCA), admitted to our intensive care unit (ICU) in 2006-2009...
January 2011: Vnitr̆ní Lékar̆ství
Rajendra H Mehta, Aijing Z Starr, Renato D Lopes, Judith S Hochman, Petr Widimsky, Karen S Pieper, Paul W Armstrong, Christopher B Granger
CONTEXT: The incidence and timing of sustained ventricular tachycardia or fibrillation (VT/VF) and its impact on outcomes in patients with ST-elevation myocardial infarction (STEMI) undergoing primary percutaneous coronary intervention (PCI) are poorly understood. OBJECTIVE: To evaluate the association of sustained VT/VF and its timing on the outcomes of patients presenting for primary PCI-an aim not prespecified in the APEX AMI trial. DESIGN, SETTING, AND PATIENTS: We studied 5745 STEMI patients presenting for primary PCI at 296 hospitals in 17 countries between July 13, 2004, and May 11, 2006, from the APEX AMI trial...
May 6, 2009: JAMA: the Journal of the American Medical Association
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