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Mechanical skin closure

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https://www.readbyqxmd.com/read/28017831/stress-signals-mediated-by-membranous-glucocorticoid-receptor-activate-plc-pkc-gsk-3%C3%AE-%C3%AE-catenin-pathway-to-inhibit-wound-closure
#1
Ivan Jozic, Sasa Vukelic, Olivera Stojadinovic, Liang Liang, Horacio A Ramirez, Irena Pastar, Marjana Tomic Canic
Glucocorticoids (GCs), key mediators of stress signals, are also potent wound healing inhibitors. To understand how stress signals inhibit wound healing, we investigated the role of membranous glucocorticoid receptor (mbGR) by using cell-impermeable BSA-conjugated Dexamethasone. We found that mbGR inhibits keratinocyte migration and wound closure by activating a Wnt-like PLC/PKC signaling cascade. Rapid activation of mbGR/PLC/PKC further leads to activation of known biomarkers of non-healing found in patients, β-catenin and c-myc...
December 22, 2016: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/28012327/incarcerated-and-eventrated-abdominal-wall-hernia-reconstruction-with-autologous-double-layer-dermal-graft-in-the-field-of-purulent-peritonitis-a-case-report
#2
Gábor Martis, Máté Rózsahegyi, János Deák, László Damjanovich
INTRODUCTION: Double-layer dermal grafts are used for the management of complicated abdominal wall hernias in obese, high risk patients. The method has not yet been used in case of emergency in septic/dirty environment. CASE REPORT: A 76-year old female patient (BMI 36.7kg/m(2)) was admitted with mechanical bowel obstruction and sepsis caused by a third time recurred, incarcerated and eventrated abdominal wall hernia. During the emergency surgery perforation of the terminal ileum and the ascending colon was detected, along with a feculent peritonitis and extended abdominal wall necrosis...
December 6, 2016: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/28004651/autophagy-a-brief-overview-in-perspective-of-dermatology
#3
REVIEW
Rahul Nagar
Autophagy, literally meaning "self-eating," is an intracellular catabolic process of delivering cytosol and/or its specific content to the lysosomes for degradation.The resulting macromolecular constituents are recycled and utilized again by the cells. Basal level autophagy plays an important role in cellular homeostasis through the elimination of the old or damaged organelles, as well as aggregated intracellular proteins. Autophagy refers to sequestration of intact organelles along with a portion of cytosol, into a double-or multi-membrane structure known as phagophore, which elongates, and after closure, forms a vesicular structure known as the autophagosome...
December 20, 2016: Indian Journal of Dermatology, Venereology and Leprology
https://www.readbyqxmd.com/read/27997709/the-role-of-allogenic-keratin-derived-dressing-in-wound-healing-in-a-mouse-model
#4
Marek Konop, Dorota Sulejczak, Joanna Czuwara, Piotr Kosson, Aleksandra Misicka, Aandrzej W Lipkowski, Lidia Rudnicka
: Keratin is an interesting protein needed for wound healing and tissue recovery. We have recently proposed a new, simple and inexpensive method to obtain fur and hair keratin-derived biomaterials suitable for medical application. The aim of the study was to evaluate the role of the fur keratin derived protein (FKDP) dressing in the allogenic full-thickness surgical skin wound model. RESULTS: The data obtained using scanning electron microscopy showed that employed processed biomaterial had higher surface porosity compared to control raw material...
December 20, 2016: Wound Repair and Regeneration
https://www.readbyqxmd.com/read/27989746/tension-re-builds-biophysical-mechanisms-of-embryonic-wound-repair
#5
REVIEW
Teresa Zulueta-Coarasa, Rodrigo Fernandez-Gonzalez
Embryonic tissues display an outstanding ability to rapidly repair wounds. Epithelia, in particular, serve as protective layers that line internal organs and form the skin. Thus, maintenance of epithelial integrity is of utmost importance for animal survival, particularly at embryonic stages, when an immune system has not yet fully developed. Rapid embryonic repair of epithelial tissues is conserved across species, and involves the collective migration of the cells around the wound. The migratory cell behaviours associated with wound repair require the generation and transmission of mechanical forces, not only for the cells to move, but also to coordinate their movements...
December 15, 2016: Mechanisms of Development
https://www.readbyqxmd.com/read/27942408/chest-wall-reconstruction-after-extended-resection
#6
REVIEW
Christopher W Seder, Gaetano Rocco
Extensive chest wall resection and reconstruction is a challenging procedure that requires a multidisciplinary approach, including input from thoracic surgeons, plastic surgeons, neurosurgeons, and radiation oncologists. The primary goals of any chest wall reconstruction is to obliterate dead space, restore chest wall rigidity, preserve pulmonary mechanics, protect intrathoracic organs, provide soft tissue coverage, minimize deformity, and allow patients to receive adjuvant radiotherapy. Successful chest wall reconstruction requires the re-establishment of skeletal stability to prevent chest wall hernias, avoids thoracoplasty-like contraction of the operated side, protects underlying viscera, and maintain a cosmetically-acceptable appearance...
November 2016: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/27916357/triclosan-sutures-for-surgical-site-infection-in-colorectal-cancer
#7
Kanefumi Yamashita, Shinsuke Takeno, Seiichiro Hoshino, Hironari Shiwaku, Naoya Aisu, Yoichiro Yoshida, Syu Tanimura, Yuichi Yamashita
BACKGROUND: Among all procedures, surgical site infections (SSIs) in colorectal surgery continue to have the highest rate, accounting for 5%-45%. To prevent the bacterial colonization of suture material, which disables local mechanisms of wound decontamination, triclosan-coated sutures were developed. We assessed the effectiveness of triclosan-coated sutures used for skin closure on the rate of SSIs in colorectal cancer surgery. METHODS: Until August 2012, we used conventional methods for skin closure in colorectal cancer surgery at the Department of Gastroenterological Surgery, Fukuoka University Faculty of Medicine...
November 2016: Journal of Surgical Research
https://www.readbyqxmd.com/read/27882274/mechanics-of-wound-closure-emerging-tape-based-wound-closure-technology-vs-traditional-methods
#8
Kemal Levi, Kei Ichiryu, Pelin Kefel, Juergen Keller, Jon Grice, Ori Belson, Eric Storne, Bauback Safa
To date, there is still a lack of understanding of how wound closure methods perform comparatively under daily bodily movement during the course of healing and how they affect the mechanics of healing. The present study is a first step in understanding and objectively quantifying the gap. The study provides both a new method of metrology for noninvasive evaluation of skin mechanics at the onset of wound healing and an emerging tape-based wound closure technology. The latter shows better performance with respect to commonly used staples and sutures, holding the wound intact and providing uniform mechanical support across the incision...
October 12, 2016: Curēus
https://www.readbyqxmd.com/read/27868279/involvement-of-dpp-iv-cd26-in-cutaneous-wound-healing-process-in-mice
#9
Lara Baticic Pucar, Ester Pernjak Pugel, Dijana Detel, Jadranka Varljen
Dipeptidyl peptidase IV (DPP IV/CD26) is a widely distributed multifunctional protein that plays a significant role in different physiological as well as pathological processes having a broad spectrum of bioactive substrates and immunomodulative properties. It has potential influence on different processes crucial for wound healing, including cell adhesion, migration, apoptosis and extracellular matrix degradation. However, despite its known enzymatic and immunomodulative functions, limited data characterize the role of DPP IV/CD26 in cutaneous wound healing mechanisms...
November 21, 2016: Wound Repair and Regeneration
https://www.readbyqxmd.com/read/27803921/use-of-adipose-derived-stem-cells-to-support-topical-skin-adhesive-for-wound-closure-a-preliminary-report-from-animal-in-vivo-study
#10
Maciej Nowacki, Katarzyna Pietkun, Arkadiusz Jundziłł, Tomasz Kloskowski, Dariusz Grzanka, Joanna Skopinska-Wisniewska, Kinga Scibior, Maciej Gagat, Marta Pokrywczyńska, Alina Grzanka, Wojciech Zegarski, Rafał Czajkowski, Tomasz Drewa, Barbara Zegarska
The aim of this study was to determine the local and systemic effects of adipose-derived stem cells (ADSCs) as a component of topical skin adhesive in an animal artificial wound closure model. In presented study the cosmetic effects, histological analysis, mechanical properties, and cell migration have been assessed to evaluate the usefulness of ADSCs as supporting factor for octyl blend cyanoacrylate adhesive. The total of 40 rats were used and divided into six groups. In the Study Group, ADSCs were administered by multipoint injection of the six surrounding intrawound areas with additional freely leaving procedure of the cells between the skin flaps just before applying adhesive to close the wound...
2016: BioMed Research International
https://www.readbyqxmd.com/read/27755049/fabrication-of-waterproof-breathable-composite-liquid-dressing-and-its-application-in-diabetic-skin-ulcer-repair
#11
Dong-Lin Xia, Yan-Pei Chen, Yu-Fei Wang, Xiao-Dong Li, Ning Bao, Hong He, Hai-Ying Gu
OBJECTIVES: Diabetic patients are at increased risk of severe skin infections. Covering the wound as early as possible can prevent infection and shorten the course of treatment. In this study, the authors fabricated a waterproof and breathable composite liquid dressing (CLD) that formed a barrier to bacteria and shortened healing time of diabetic rat skin ulcers. METHODS: The CLD was prepared in a formulation that, on evaporation of the liquid carrier, acts as a waterproof, breathable coating on injured skin...
November 2016: Advances in Skin & Wound Care
https://www.readbyqxmd.com/read/27743751/use-of-a-dermal-regeneration-template-wound-dressing-in-the-treatment-of-combat-related-upper-extremity-soft-tissue-injuries
#12
Ian L Valerio, Zachary Masters, Jonathan G Seavey, George C Balazs, Derek Ipsen, Scott M Tintle
PURPOSE: To assess the outcomes of treatment with a dermal regeneration template (DRT) in a cohort of combat casualties with severe upper extremity injuries. METHODS: Records of all active duty military patients treated with DRT at our institution between November 2009 and July 2013 were screened. Inclusion criteria were upper extremity open wounds sustained during combat, requiring split-thickness or full-thickness skin grafting for closure. The primary outcome measure was wound healing after the first attempt at definitive treatment (defined as the first application of split-thickness or full-thickness skin graft)...
December 2016: Journal of Hand Surgery
https://www.readbyqxmd.com/read/27743736/effects-of-small-fiber-neuropathy-induced-by-resiniferatoxin-on-skin-healing-and-axonal-regrowth-after-burn
#13
Betty Laverdet, Dorothée Girard, Audrey Bayout, Nelly Bordeau, Claire Demiot, Alexis Desmoulière
BACKGROUND: Damage to the peripheral nervous system influences wound healing and, after a deep burn, imperfect cutaneous nerve regeneration occurs. A third-degree burn model was developed in rats combined with the use of resiniferatoxin (RTX), known to promote sensory neuropathy. METHODS: Rats were injected intraperitoneally either with RTX or vehicle. A mechanical sensory assay and the hot plate thermal sensory test were performed. The structural integrity of the sciatic nerve was assessed using transmission electron microcopy...
October 12, 2016: Burns: Journal of the International Society for Burn Injuries
https://www.readbyqxmd.com/read/27679959/exercise-treadmills-a-cause-of-significant-hand-burns-in-young-children
#14
Dana L Noffsinger, Susan R Johnson, Krista Wheeler, Junxin Shi, Huiyun Xiang, Jonathan I Groner
A pediatric nurse practitioner and an occupational therapist were impressed by the number and severity of treadmill-related hand burns encountered in their outpatient burn clinic. They observed that treadmill burns appeared to be deeper compared with other contact hand burns. Literature review revealed that research was inadequate in this area. A retrospective chart review was conducted, and a total of 384 patients were found to receive treatments at a regional level 1 pediatric burn center for treadmill and contact hand burns from 2010 to 2014...
September 20, 2016: Journal of Burn Care & Research: Official Publication of the American Burn Association
https://www.readbyqxmd.com/read/27648618/evaluation-of-the-surgery-wound-healing-process-using-self-adaptive-skin-suture-or-mechanical-stapler
#15
Ewa Sztuczka, Marek Jackowski, Wioletta Żukowska
UNLABELLED: Wound healing is a complex and time-phased process. The occurrence of numerous negative conditions as well as external factors have a significant influence on the risk of potential complications. Preparing the patient for surgery, attention should be paid to a number of factors determining the proper healing process. The aim of the study was to compare the results of the early period of surgical wound healing process with access via laparotomy using techniques, which are self-adaptive sutures and mechanical staplers used for skin closure...
September 1, 2016: Polski Przeglad Chirurgiczny
https://www.readbyqxmd.com/read/27640802/-a-case-of-combination-therapy-by-vacuum-assisted-closure-along-with-skin-graft-for-scleroderma-with-common-wart
#16
Junjie Luo, Xinghua Yang
Scleroderma is a kind of connective tissue disease characterized by skin and other systems fibrosis. The underlying mechanisms for this disease are poorly understood due to its complexity. It is very difficult for scleroderma patient to heal the wound due to the special pathological characteristic of scleroderma.
September 28, 2016: Zhong Nan da Xue Xue Bao. Yi Xue Ban, Journal of Central South University. Medical Sciences
https://www.readbyqxmd.com/read/27607352/titanium-wound-chambers-for-wound-healing-research
#17
Kristo Nuutila, Mansher Singh, Carla Kruse, Justin Philip, Edward J Caterson, Elof Eriksson
Standardized and reproducible animal models are crucial in medical research. Rodents are commonly used in wound healing studies since, they are easily available, affordable and simple to handle and house. However, the most significant limitation of rodent models is that the wounds heal by contraction while in humans the primary mechanisms of healing are reepithelialization and granulation tissue formation. The robust contraction results in faster wound closure that complicates the reproducibility of rodent studies in clinical trials...
November 2016: Wound Repair and Regeneration
https://www.readbyqxmd.com/read/27600980/antecedent-thermal-injury-worsens-split-thickness-skin-graft-quality-a-clinically-relevant-porcine-model-of-full-thickness-burn-excision-and-grafting
#18
Anders H Carlsson, Lloyd F Rose, John L Fletcher, Jesse C Wu, Kai P Leung, Rodney K Chan
Current standard of care for full-thickness burn is excision followed by autologous split-thickness skin graft placement. Skin grafts are also frequently used to cover surgical wounds not amenable to linear closure. While all grafts have potential to contract, clinical observation suggests that antecedent thermal injury worsens contraction and impairs functional and aesthetic outcomes. This study evaluates the impact of antecedent full-thickness burn on split-thickness skin graft scar outcomes and the potential mediating factors...
September 3, 2016: Burns: Journal of the International Society for Burn Injuries
https://www.readbyqxmd.com/read/27591919/accelerated-wound-healing-in-a-diabetic-rat-model-using-decellularized-dermal-matrix-and-human-umbilical-cord-perivascular-cells
#19
P Brouki Milan, N Lotfibakhshaiesh, M T Joghataie, J Ai, A Pazouki, D L Kaplan, S Kargozar, N Amini, M R Hamblin, M Mozafari, A Samadikuchaksaraei
: There is an unmet clinical need for novel wound healing strategies to treat full thickness skin defects, especially in diabetic patients. We hypothesized that a scaffold could perform dual roles of a biomechanical support and a favorable biochemical environment for stem cells. Human umbilical cord perivascular cells (HUCPVCs) have been recently reported as a type of mesenchymal stem cell that can accelerate early wound healing in skin defects. However, there are only a limited number of studies that have incorporated these cells into natural scaffolds for dermal tissue engineering...
November 2016: Acta Biomaterialia
https://www.readbyqxmd.com/read/27518488/preoperative-but-not-postoperative-flurbiprofen-axetil-alleviates-remifentanil-induced-hyperalgesia-after-laparoscopic-gynecological-surgery-a-prospective-randomized-double-blinded-trial
#20
Linlin Zhang, Ruichen Shu, Qi Zhao, Yize Li, Chunyan Wang, Haiyun Wang, Yonghao Yu, Guolin Wang
BACKGROUND: Acute remifentanil exposure during intraoperative analgesia might generate sensitivity-enhancing to noxious stimuli and nociceptive responses to innoxious irritation. Cyclooxygenase inhibition was demonstrated to attenuate experimental remifentanil-induced hyperalgesia (RIH) in rodents and human volunteers. the study aimed to compare effects of preoperative and postoperative flurbiprofen axetil on RIH after surgery. METHODS: Ninety patients undergoing elective laparoscopic gynaecological surgery were randomly assigned to receive either intravenous placebo before anesthesia induction (group C); or intravenous flurbiprofen axetil 1...
August 11, 2016: Clinical Journal of Pain
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