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Mechanical skin closure

Kemal Levi, Kei Ichiryu, Pelin Kefel, Juergen Keller, Jon Grice, Ori Belson, Eric Storne, Bauback Safa
To date, there is still a lack of understanding of how wound closure methods perform comparatively under daily bodily movement during the course of healing and how they affect the mechanics of healing. The present study is a first step in understanding and objectively quantifying the gap. The study provides both a new method of metrology for noninvasive evaluation of skin mechanics at the onset of wound healing and an emerging tape-based wound closure technology. The latter shows better performance with respect to commonly used staples and sutures, holding the wound intact and providing uniform mechanical support across the incision...
October 12, 2016: Curēus
Lara Baticic Pucar, Ester Pernjak Pugel, Dijana Detel, Jadranka Varljen
Dipeptidyl peptidase IV (DPP IV/CD26) is a widely distributed multifunctional protein that plays a significant role in different physiological as well as pathological processes having a broad spectrum of bioactive substrates and immunomodulative properties. It has potential influence on different processes crucial for wound healing, including cell adhesion, migration, apoptosis and extracellular matrix degradation. However, despite its known enzymatic and immunomodulative functions, limited data characterize the role of DPP IV/CD26 in cutaneous wound healing mechanisms...
November 21, 2016: Wound Repair and Regeneration
Maciej Nowacki, Katarzyna Pietkun, Arkadiusz Jundziłł, Tomasz Kloskowski, Dariusz Grzanka, Joanna Skopinska-Wisniewska, Kinga Scibior, Maciej Gagat, Marta Pokrywczyńska, Alina Grzanka, Wojciech Zegarski, Rafał Czajkowski, Tomasz Drewa, Barbara Zegarska
The aim of this study was to determine the local and systemic effects of adipose-derived stem cells (ADSCs) as a component of topical skin adhesive in an animal artificial wound closure model. In presented study the cosmetic effects, histological analysis, mechanical properties, and cell migration have been assessed to evaluate the usefulness of ADSCs as supporting factor for octyl blend cyanoacrylate adhesive. The total of 40 rats were used and divided into six groups. In the Study Group, ADSCs were administered by multipoint injection of the six surrounding intrawound areas with additional freely leaving procedure of the cells between the skin flaps just before applying adhesive to close the wound...
2016: BioMed Research International
Dong-Lin Xia, Yan-Pei Chen, Yu-Fei Wang, Xiao-Dong Li, Ning Bao, Hong He, Hai-Ying Gu
OBJECTIVES: Diabetic patients are at increased risk of severe skin infections. Covering the wound as early as possible can prevent infection and shorten the course of treatment. In this study, the authors fabricated a waterproof and breathable composite liquid dressing (CLD) that formed a barrier to bacteria and shortened healing time of diabetic rat skin ulcers. METHODS: The CLD was prepared in a formulation that, on evaporation of the liquid carrier, acts as a waterproof, breathable coating on injured skin...
November 2016: Advances in Skin & Wound Care
Ian L Valerio, Zachary Masters, Jonathan G Seavey, George C Balazs, Derek Ipsen, Scott M Tintle
PURPOSE: To assess the outcomes of treatment with a dermal regeneration template (DRT) in a cohort of combat casualties with severe upper extremity injuries. METHODS: Records of all active duty military patients treated with DRT at our institution between November 2009 and July 2013 were screened. Inclusion criteria were upper extremity open wounds sustained during combat, requiring split-thickness or full-thickness skin grafting for closure. The primary outcome measure was wound healing after the first attempt at definitive treatment (defined as the first application of split-thickness or full-thickness skin graft)...
October 12, 2016: Journal of Hand Surgery
Betty Laverdet, Dorothée Girard, Audrey Bayout, Nelly Bordeau, Claire Demiot, Alexis Desmoulière
BACKGROUND: Damage to the peripheral nervous system influences wound healing and, after a deep burn, imperfect cutaneous nerve regeneration occurs. A third-degree burn model was developed in rats combined with the use of resiniferatoxin (RTX), known to promote sensory neuropathy. METHODS: Rats were injected intraperitoneally either with RTX or vehicle. A mechanical sensory assay and the hot plate thermal sensory test were performed. The structural integrity of the sciatic nerve was assessed using transmission electron microcopy...
October 12, 2016: Burns: Journal of the International Society for Burn Injuries
Dana L Noffsinger, Susan R Johnson, Krista Wheeler, Junxin Shi, Huiyun Xiang, Jonathan I Groner
A pediatric nurse practitioner and an occupational therapist were impressed by the number and severity of treadmill-related hand burns encountered in their outpatient burn clinic. They observed that treadmill burns appeared to be deeper compared with other contact hand burns. Literature review revealed that research was inadequate in this area. A retrospective chart review was conducted, and a total of 384 patients were found to receive treatments at a regional level 1 pediatric burn center for treadmill and contact hand burns from 2010 to 2014...
September 20, 2016: Journal of Burn Care & Research: Official Publication of the American Burn Association
Ewa Sztuczka, Marek Jackowski, Wioletta Żukowska
UNLABELLED: Wound healing is a complex and time-phased process. The occurrence of numerous negative conditions as well as external factors have a significant influence on the risk of potential complications. Preparing the patient for surgery, attention should be paid to a number of factors determining the proper healing process. The aim of the study was to compare the results of the early period of surgical wound healing process with access via laparotomy using techniques, which are self-adaptive sutures and mechanical staplers used for skin closure...
September 1, 2016: Polski Przeglad Chirurgiczny
Junjie Luo, Xinghua Yang
Scleroderma is a kind of connective tissue disease characterized by skin and other systems fibrosis. The underlying mechanisms for this disease are poorly understood due to its complexity. It is very difficult for scleroderma patient to heal the wound due to the special pathological characteristic of scleroderma.
September 28, 2016: Zhong Nan da Xue Xue Bao. Yi Xue Ban, Journal of Central South University. Medical Sciences
Kristo Nuutila, Mansher Singh, Carla Kruse, Justin Philip, Edward J Caterson, Elof Eriksson
Standardized and reproducible animal models are crucial in medical research. Rodents are commonly used in wound healing studies since, they are easily available, affordable and simple to handle and house. However, the most significant limitation of rodent models is that the wounds heal by contraction while in humans the primary mechanisms of healing are reepithelialization and granulation tissue formation. The robust contraction results in faster wound closure that complicates the reproducibility of rodent studies in clinical trials...
September 8, 2016: Wound Repair and Regeneration
Anders H Carlsson, Lloyd F Rose, John L Fletcher, Jesse C Wu, Kai P Leung, Rodney K Chan
Current standard of care for full-thickness burn is excision followed by autologous split-thickness skin graft placement. Skin grafts are also frequently used to cover surgical wounds not amenable to linear closure. While all grafts have potential to contract, clinical observation suggests that antecedent thermal injury worsens contraction and impairs functional and aesthetic outcomes. This study evaluates the impact of antecedent full-thickness burn on split-thickness skin graft scar outcomes and the potential mediating factors...
September 3, 2016: Burns: Journal of the International Society for Burn Injuries
P Brouki Milan, N Lotfibakhshaiesh, M T Joghataie, J Ai, A Pazouki, D L Kaplan, S Kargozar, N Amini, M R Hamblin, M Mozafari, A Samadikuchaksaraei
: There is an unmet clinical need for novel wound healing strategies to treat full thickness skin defects, especially in diabetic patients. We hypothesized that a scaffold could perform dual roles of a biomechanical support and a favorable biochemical environment for stem cells. Human umbilical cord perivascular cells (HUCPVCs) have been recently reported as a type of mesenchymal stem cell that can accelerate early wound healing in skin defects. However, there are only a limited number of studies that have incorporated these cells into natural scaffolds for dermal tissue engineering...
November 2016: Acta Biomaterialia
Linlin Zhang, Ruichen Shu, Qi Zhao, Yize Li, Chunyan Wang, Haiyun Wang, Yonghao Yu, Guolin Wang
BACKGROUND: Acute remifentanil exposure during intraoperative analgesia might generate sensitivity-enhancing to noxious stimuli and nociceptive responses to innoxious irritation. Cyclooxygenase inhibition was demonstrated to attenuate experimental remifentanil-induced hyperalgesia (RIH) in rodents and human volunteers. the study aimed to compare effects of preoperative and postoperative flurbiprofen axetil on RIH after surgery. METHODS: Ninety patients undergoing elective laparoscopic gynaecological surgery were randomly assigned to receive either intravenous placebo before anesthesia induction (group C); or intravenous flurbiprofen axetil 1...
August 11, 2016: Clinical Journal of Pain
A Belkhou, C François, Y Bennis, V Duquennoy-Martinot, P Guerreschi
Congenital skin aplasia, or aplasia cutis congenita (ACC) is a rare congenital disease. It is characterized by the absence of skin at birth, localized or widespread, of one or several areas. This condition commonly involve the scalp but can also involve more rarely the trunk or limbs. However it is most frequently an isolated disorder, it can be associated with other anomalies, such as the Adams-Oliver syndrome, the association with a fetus papyraceus or with an epidermolysis bullosa. Many hypothesis have been suggested: vascular, genetic, traumatic, pharmacological or an anomaly in the neural tube closure process, but the exact mechanism is still unknown...
October 2016: Annales de Chirurgie Plastique et Esthétique
Oscar Sasso, Silvia Pontis, Andrea Armirotti, Giorgia Cardinali, Daniela Kovacs, Marco Migliore, Maria Summa, Guillermo Moreno-Sanz, Mauro Picardo, Daniele Piomelli
The intracellular serine amidase, fatty acid amide hydrolase (FAAH), degrades a heterogeneous family of lipid-derived bioactive molecules that include amides of long-chain fatty acids with taurine [N-acyl-taurines (NATs)]. The physiological functions of the NATs are unknown. Here we show that genetic or pharmacological disruption of FAAH activity accelerates skin wound healing in mice and stimulates motogenesis of human keratinocytes and differentiation of human fibroblasts in primary cultures. Using untargeted and targeted lipidomics strategies, we identify two long-chain saturated NATs-N-tetracosanoyl-taurine [NAT(24:0)] and N-eicosanoyl-taurine [NAT(20:0)]-as primary substrates for FAAH in mouse skin, and show that the levels of these substances sharply decrease at the margins of a freshly inflicted wound to increase again as healing begins...
July 26, 2016: Proceedings of the National Academy of Sciences of the United States of America
Zhongyang Liu, Yingbin Xu, Xiaorong Zhang, Guangping Liang, Lei Chen, Julin Xie, Jinming Tang, Jingling Zhao, Bin Shu, Shaohai Qi, Jian Chen, Gaoxing Luo, Jun Wu, Weifeng He, Xusheng Liu
The skin serves as a physical and chemical barrier to provide an initial line of defense against environmental threats; however, this function is impaired in diabetes. Vγ4 γ δ T cells in the dermis are an important part of the resident cutaneous immunosurveillance program, but these cells have yet to be explored in the context of diabetes. In this study, we observed that the impaired maintenance of dermal Vγ4 γ δ T cells is caused by reduced production of IL-7 in the skin of diabetic mice, which was closely associated with weakened activation of the mTOR pathway in the epidermis of diabetic mice...
2016: American Journal of Translational Research
Jiang Wu, Jingjing Zhu, Chaochao He, Zecong Xiao, Jingjing Ye, Yi Li, Anqi Chen, Hongyu Zhang, Xiaokun Li, Li Lin, Yingzheng Zhao, Jie Zheng, Jian Xiao
Wound therapy remains a clinical challenge. Incorporation of growth factors (GFs) into heparin-functionalized polymer hydrogel is considered as a promising strategy to improve wound healing efficiency. However, different GFs incorporation into the same heparin-based hydrogels often lead to different wound healing effects, and the underlying GF-induced wound healing mechanisms still remain elusive. Herein, we developed a thermos-sensitive heparin-poloxamer (HP) hydrogel to load and deliver different GFs (aFGF and bFGF) for wound healing in vivo...
July 27, 2016: ACS Applied Materials & Interfaces
Aleksander Skardal, Sean V Murphy, Kathryn Crowell, David Mack, Anthony Atala, Shay Soker
For many cellular therapies being evaluated in preclinical and clinical trials, the mechanisms behind their therapeutic effects appear to be the secretion of growth factors and cytokines, also known as paracrine activity. Often, delivered cells are transient, and half-lives of the growth factors that they secrete are short, limiting their long-term effectiveness. The goal of this study was to optimize a hydrogel system capable of in situ cell delivery that could sequester and release growth factors secreted from those cells after the cells were no longer present...
June 28, 2016: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
Zhongyang Liu, Yingbin Xu, Lei Chen, Julin Xie, Jinming Tang, Jingling Zhao, Bin Shu, Shaohai Qi, Jian Chen, Guangping Liang, Gaoxing Luo, Jun Wu, Weifeng He, Xusheng Liu
The impairment of skin repair in diabetic patients can lead to increased morbidity and mortality. Proper proliferation, apoptosis and migration in keratinocytes are vital for skin repair, but in diabetic patients, hyperglycemia impairs this process. Dendritic epidermal T cells (DETCs) are an important part of the resident cutaneous immunosurveillance program. We observed a reduction in the number of DETCs in a streptozotocin-induced diabetic mouse model. This reduction in DETCs resulted in decreased IGF-1 and KGF production in the epidermis, which is closely associated with diabetic delayed wound closure...
2016: American Journal of Translational Research
Chanisa Kiatsurayanon, François Niyonsaba, Panjit Chieosilapatham, Ko Okumura, Shigaku Ikeda, Hideoki Ogawa
BACKGROUND: In addition to their antimicrobial activities, antimicrobial peptides, also known as host defense peptides (HDPs) activate keratinocytes; promote wound healing; and improve the skin barrier. AG-30/5C is a novel angiogenic HDP that activates various functions of fibroblasts and endothelial cells, including cytokine/chemokine production and wound healing. OBJECTIVES: To investigate whether AG-30/5C activates human keratinocytes and to examine the underlying mechanisms...
September 2016: Journal of Dermatological Science
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