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Mechanical skin closure

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https://www.readbyqxmd.com/read/29735202/zorro-z-omphaloplasty-repair-for-omphalocele
#1
Michel Jean-Luc, Kassir Rani, Harper Luke, Gavage Laurent, Frade Fernanda, Clermidi Pauline, Sauvat Frederique, Ramful Duksha
PURPOSE: To suggest a novel technique for omphalocele closure which uses the circular base of the umbilical cord, thus allowing for a more physiological healing process and natural-looking scar. METHODS: Among 16 neonates operated for omphalocele between 2011 and 2016, 12 were closed with a one-stage procedure using a Z omphaloplasty (ZORRO). Median gestational age was 36.5 weeks; median birth weight was 3210 g. The umbilical arteries were divided and ligated outside the peritoneal cavity above the parietal musculocutaneous plane...
April 6, 2018: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/29734114/the-early-signaling-pathway-of-live-yeast-cell-derivative-in-thp-1-monocytes
#2
Eric I Gruenstein, Donna J Schlemm, Mridula Bethi, Stephen J Keller
Live yeast cell derivative (LYCD) is a medicinal yeast extract that has been used in the treatment of burns, wounds and hemorrhoids for over 70 years. It has been shown to enhance the closure of skin wounds in diabetic mice by increasing inflammation, angiogenesis, formation of granulation tissue and epithelial migration. An active fraction of LYCD has been identified as a mixture of peptides ranging in size from 5 kDA to 17 kDA. Despite its widespread use over many years, understanding of the mechanism by which LYCD acts to effect tissue repair responses is very limited...
April 22, 2018: Cell Calcium
https://www.readbyqxmd.com/read/29701425/analgesia-management-for-mitral-valve-repair-via-minithoracotomy-a-case-report
#3
Andreia Fernandes, Clara Gaio Lima, Nelson Paulo, Catarina Celestino, Ana Fonte Boa, Fátima Lima, Manuela Vieira
INTRODUCTION: Minimally invasive cardiac surgery (MICS), via minithoracotomy, is thought to be a fast track to extubation and recovery after surgery. Chronic pain, due to intercostal nerve injury, develops in up to 50% of postthoracotomy patients.A number of regional anaesthesia and analgesia techniques may be employed, and the anaesthesiologists play a key role in facilitating optimal outcomes after surgery. METHODS: We report a case of postoperative pain management with a local anesthetic infiltration for MICS...
July 2017: Revista Portuguesa de Cirurgia Cardio-torácica e Vascular
https://www.readbyqxmd.com/read/29670882/stomal-closure-strategies-to-prevent-incisional-hernia
#4
Rhiannon L Harries, Jared Torkington
Incisional hernias following ostomy reversal occur frequently. Incisional hernias at the site of a previous stoma closure can cause significant morbidity, impaired quality of life, lead to life-threatening hernia incarceration or strangulation and result in a significant financial burden on health care systems Despite this, the evidence base on the subject is limited. Many recognised risk factors for the development of incisional hernia following ostomy reversal are related to patient factors such as age, malignancy, diabetes, COPD, hypertension and obesity, and are not easily correctable...
2018: Frontiers in Surgery
https://www.readbyqxmd.com/read/29656516/mir-21-ameliorates-aged-associated-skin-wound-healing-defects-in-mice
#5
Shuang Long, Na Zhao, Lan Ge, Guojian Wang, Xinze Ran, Junping Wang, Yongping Su, Tao Wang
BACKGROUND: The cellular and molecular mechanisms for aged-associated delay of cutaneous wound healing are still not well understood. Our previous results show that miR-21 plays key roles during skin wound healing. We presumed that dysregulation of miR-21 may involve in aged-associated defects in wound healing and miR-21 may be one potential therapeutic target to ameliorate wound defects in elderly subjects. METHODS: Circular full thickness excisional wounds were made on the dorsal skin of young (2-month-old) and aged (12-month-old) female mice...
April 15, 2018: Journal of Gene Medicine
https://www.readbyqxmd.com/read/29656072/enhanced-wound-healing-of-tissue-engineered-human-corneas-through-altered-phosphorylation-of-the-creb-and-akt-signal-transduction-pathways
#6
Camille Couture, Pascale Desjardins, Karine Zaniolo, Lucie Germain, Sylvain L Guérin
The cornea is a transparent organ, highly specialized and unique that is continually subjected to abrasive forces and occasional mechanical or chemical trauma because of its anatomical localization. Upon injury, the extracellular matrix (ECM) rapidly changes to promote wound healing through integrin-dependent activation of specific signal transduction mediators whose contribution is to favor faster closure of the wound by altering the adhesive and migratory properties of the cells surrounding the damaged area...
April 12, 2018: Acta Biomaterialia
https://www.readbyqxmd.com/read/29614431/3d-cell-printing-of-in-vitro-stabilized-skin-model-and-in-vivo-pre-vascularized-skin-patch-using-tissue-specific-extracellular-matrix-bioink-a-step-towards-advanced-skin-tissue-engineering
#7
Byoung Soo Kim, Yang Woo Kwon, Jeong-Sik Kong, Gyu Tae Park, Ge Gao, Wonil Han, Moon-Bum Kim, Hyungseok Lee, Jae Ho Kim, Dong-Woo Cho
3D cell-printing technique has been under spotlight as an appealing biofabrication platform due to its ability to precisely pattern living cells in pre-defined spatial locations. In skin tissue engineering, a major remaining challenge is to seek for a suitable source of bioink capable of supporting and stimulating printed cells for tissue development. However, current bioinks for skin printing rely on homogeneous biomaterials, which has several shortcomings such as insufficient mechanical properties and recapitulation of microenvironment...
March 23, 2018: Biomaterials
https://www.readbyqxmd.com/read/29608162/a-novel-in-vitro-wound-healing-assay-to-evaluate-cell-migration
#8
Floriana Cappiello, Bruno Casciaro, Maria Luisa Mangoni
The aim of this work is to show a novel method to evaluate the ability of some immunomodulatory molecules, such as antimicrobial peptides (AMPs), to stimulate cell migration. Importantly, cell migration is a rate-limiting event during the wound-healing process to re-establish the integrity and normal function of tissue layers after injury. The advantage of this method over the classical assay, which is based on a manually made scratch in a cell monolayer, is the usage of special silicone culture inserts providing two compartments to create a cell-free pseudo-wound field with a well-defined width (500 μm)...
March 17, 2018: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/29575792/dynamic-multiphoton-imaging-of-acellular-dermal-matrix-scaffolds-seeded-with-mesenchymal-stem-cells-in-diabetic-wound-healing
#9
Jing Chu, Panpan Shi, Xiaoyuan Deng, Ying Jin, Hao Liu, Maosheng Chen, Xue Han, Hanping Liu
Significantly effective therapies need to be developed for chronic non-healing diabetic wounds. In this work, the topical transplantation of mesenchymal stem cell (MSC) seeded on an acellular dermal matrix (ADM) scaffold is proposed as a novel therapeutic strategy for diabetic cutaneous wound healing. GFP-labeled MSCs were co-cultured with an ADM scaffold that was decellularized from normal mouse skin. These cultures were subsequently transplanted as a whole into the full-thickness cutaneous wound site in streptozotocin (STZ)-induced diabetic mice...
March 25, 2018: Journal of Biophotonics
https://www.readbyqxmd.com/read/29505115/macrophage-derived-gpnmb-accelerates-skin-healing
#10
Walison N Silva, Pedro H D M Prazeres, Ana E Paiva, Luiza Lousado, Anaelise O M Turquetti, Rodrigo S N Barreto, Erika Costa de Alvarenga, Maria A Miglino, Ricardo Gonçalves, Akiva Mintz, Alexander Birbrair
Healing is a vital response important for the re-establishment of the skin integrity following injury. Delayed or aberrant dermal wound healing leads to morbidity in patients. The development of therapies to improve dermal healing would be useful. Currently, the design of efficient treatments is stalled by the lack of detailed knowledge about the cellular and molecular mechanisms involved in wound healing. Recently, using state-of-the-art technologies, it was revealed that macrophages signal via GPNMB to mesenchymal stem cells, accelerating skin healing...
March 5, 2018: Experimental Dermatology
https://www.readbyqxmd.com/read/29476889/targeted-nrf2-activation-therapy-with-rta-408-enhances-regenerative-capacity-of-diabetic-wounds
#11
Piul S Rabbani, Trevor Ellison, Bukhtawar Waqas, Darren Sultan, Salma Abdou, Joshua A David, Joshua M Cohen, Alejandro Gomez-Viso, Gretl Lam, Camille Kim, Jennifer Thomson, Daniel J Ceradini
AIMS: Though unmitigated oxidative stress in diabetic chronic non-healing wounds poses a major therapeutic challenge, currently, there are no effective pharmacological agents. We targeted the cytoprotective Nrf2/Keap1 pathway, which is dysfunctional in diabetic skin and the regenerative environment in the diabetic wound. We assessed the efficacy of a potent Nrf2-activator, RTA 408, a semi-synthetic oleanane triterpenoid, on accelerating diabetic wound healing. METHODS: Using Leprdb/db mice, we made 10 mm-diameter excisional humanized wounds in dorsal skin...
February 21, 2018: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/29456748/wound-closure-expectations-after-fasciotomy-for-paediatric-compartment-syndrome
#12
E D Shirley, V Mai, K M Neal, G M Kiebzak
Purpose: Acute compartment syndrome often requires additional surgery to achieve wound closure. Little information exists regarding the expected number of surgeries, techniques and complications after closure in paediatric patients. Methods: A retrospective chart review identified patients treated for acute compartment syndrome at four hospitals over a ten-year period. The cause of injury, type of dressing, number of surgeries, type of closure and complications were recorded...
February 1, 2018: Journal of Children's Orthopaedics
https://www.readbyqxmd.com/read/29451714/development-of-regenerative-and-flexible-fibroin-based-wound-dressings
#13
Angelica Panico, Federica Paladini, Mauro Pollini
Skin injuries represent a health problem with consequences in terms of morbidity, disability and life quality. Numerous strategies have been developed for the treatment of wounds, including skin substitutes, biomembranes, scaffolds, and smart dressings. The excellent properties of fibroin can be exploited for the development of advanced wound dressing biomaterials, aiming at promoting the wound healing process. In this work, silk fibroin films modified through the addition of glucose were developed to enhance flexibility of medical device without affecting the biocompatibility, to promote wound healing and to improve the patient well-being...
February 16, 2018: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/29407579/skin-and-scale-regeneration-after-mechanical-damage-in-a-teleost
#14
Rita A Costa, Deborah M Power
Skin wound healing has been widely studied in mammalian models but the information on teleost cutaneous healing is sparse and frequently considered in the context of viral or bacterial infections or parasitic infestations in aquaculture. In the present study a detailed time course (0 h, 6 h, 1, 2, 3 and 4 days) coupled to morphology and gene expression analysis revealed rapid regeneration of skin without scarring in a marine teleost after a superficial wound caused by the loss of a large area of scales...
March 2018: Molecular Immunology
https://www.readbyqxmd.com/read/29392187/regeneration-mechanism-for-skin-and-peripheral-nerves-clarified-at-the-organ-and-molecular-scales
#15
Ioannis V Yannas, Dimitrios S Tzeranis, Peter T C So
This article is a review of current research on the mechanism of regeneration of skin and peripheral nerves based on use of collagen scaffolds, particularly the dermis regeneration template (DRT), which is widely used clinically. DRT modifies the normal wound healing process, converting it from wound closure by contraction and scar formation to closure by regeneration. DRT achieves this modification by blocking wound contraction, which spontaneously leads to cancellation of scar formation, a process secondary to contraction...
June 2018: Current Opinion in Biomedical Engineering
https://www.readbyqxmd.com/read/29389900/the-zinc-sensing-receptor-znr-gpr39-in-health-and-disease
#16
REVIEW
Michal Hershfinkel
A distinct G-protein coupled receptor that senses changes in extracellular Zn2+ , ZnR/GPR39, was found in cells from tissues in which Zn2+ plays a physiological role. Most prominently, ZnR/GPR39 activity was described in prostate cancer, skin keratinocytes, and colon epithelial cells, where zinc is essential for cell growth, wound closure, and barrier formation. ZnR/GPR39 activity was also described in neurons that are postsynaptic to vesicular Zn2+ release. Activation of ZnR/GPR39 triggers Gαq-dependent signaling and subsequent cellular pathways associated with cell growth and survival...
February 1, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29334185/physical-properties-of-implanted-porous-bioscaffolds-regulate-skin-repair-focusing-on-mechanical-and-structural-features
#17
REVIEW
Shumeng Jiang, Sabrina Cloud Li, Chenyu Huang, Barbara Pui Chan, Yanan Du
Porous bioscaffolds are applied to facilitate skin repair since the early 1990s, but a perfect regeneration outcome has yet to be achieved. Until now, most efforts have focused on modulating the chemical properties of bioscaffolds, while physical properties are traditionally overlooked. Recent advances in mechanobiology and mechanotherapy have highlighted the importance of biomaterials' physical properties in the regulation of cellular behaviors and regenerative processes. In skin repair, the mechanical and structural features of porous bioscaffolds are two major physical properties that determine therapeutic efficacy...
March 2018: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/29330021/ccn4-wisp1-controls-cutaneous-wound-healing-by-modulating-proliferation-migration-and-ecm-expression-in-dermal-fibroblasts-via-%C3%AE-5%C3%AE-1-and-tnf%C3%AE
#18
Mitsuaki Ono, Asuka Masaki, Azusa Maeda, Tina M Kilts, Emilio S Hara, Taishi Komori, Hai Pham, Takuo Kuboki, Marian F Young
Understanding the mechanisms that control cutaneous wound healing is crucial to successfully manage repair of damaged skin. The goal of the current study was to uncover novel extracellular matrix (ECM) components that control the wound healing process. Full thickness skin defects were created in mice and used to show CCN4 up-regulation during wound-healing as early as 1 day after surgery, suggesting a role in inflammation and subsequent dermal migration and proliferation. To determine how CCN4 could regulate wound healing we used Ccn4-KO mice and showed they had delayed wound closure accompanied by reduced expression of Col1a1 and Fn mRNA...
January 10, 2018: Matrix Biology: Journal of the International Society for Matrix Biology
https://www.readbyqxmd.com/read/29328541/gm-csf-ameliorates-microvascular-barrier-integrity-via-pericyte-derived-ang-1-in-wound-healing
#19
Min Yan, Yange Hu, Min Yao, Shisan Bao, Yong Fang
Skin wound healing involves complex coordinated interactions of cells, tissues, and mediators. Maintaining microvascular barrier integrity is one of the key events for endothelial homeostasis during wound healing. Vasodilation is observed after vasoconstriction, which causes blood vessels to become porous, facilitates leukocyte infiltration and aids angiogenesis at the wound-area, postinjury. Eventually, vessel integrity has to be reestablished for vascular maturation. Numerous studies have found that granulocyte macrophage colony-stimulating factor (GM-CSF) accelerates wound healing by inducing recruitment of repair cells into the injury area and releases of cytokines...
November 2017: Wound Repair and Regeneration
https://www.readbyqxmd.com/read/29290800/exosomes-from-human-umbilical-cord-blood-accelerate-cutaneous-wound-healing-through-mir-21-3p-mediated-promotion-of-angiogenesis-and-fibroblast-function
#20
Yin Hu, Shan-Shan Rao, Zhen-Xing Wang, Jia Cao, Yi-Juan Tan, Juan Luo, Hong-Ming Li, Wei-She Zhang, Chun-Yuan Chen, Hui Xie
The application of blood plasma for soft tissue wound healing is receiving much more attention recently. Exosomes are critical paracrine mediators that can be obtained from biological fluids including plasma and be able to induce regenerative effects by transferring bioactive molecules such as microRNAs (miRNAs). This study aimed to investigate the effects of exosomes from human umbilical cord blood plasma (UCB-Exos) on wound healing and to elucidate the underlying mechanism. Methods: UCB-Exos were isolated by ultracentrifugation and subcutaneously injected into full-thickness skin wounds in mice...
2018: Theranostics
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