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https://www.readbyqxmd.com/read/28426749/molecular-characterization-tissue-tropism-and-genetic-variability-of-the-novel-mupapillomavirus-type-hpv204-and-phylogenetically-related-types-hpv1-and-hpv63
#1
Anja Šterbenc, Lea Hošnjak, Diego Chouhy, Elisa M Bolatti, Anja Oštrbenk, Katja Seme, Boštjan J Kocjan, Boštjan Luzar, Adriana A Giri, Mario Poljak
HPV204 is the only newly identified Mupapillomavirus (Mu-PV) type in more than a decade. To comprehensively characterize HPV204, we performed a detailed molecular analysis of the viral genome and evaluated its clinical relevance in comparison to the other Mu-PVs, HPV1 and HPV63. The 7,227-bp long genome of HPV204 exhibits typical genomic organization of Mu-PVs with eight open reading frames (ORFs) (E6, E7, E1, E2, E8, E4, L2, and L1). We developed three type-specific quantitative real-time PCRs and used them to test a representative collection (n = 1,006) of various HPV-associated benign and malignant neoplasms, as well as samples of clinically normal cutaneous, mucosal, and mucocutaneous origins...
2017: PloS One
https://www.readbyqxmd.com/read/28426572/nonhealing-ulcers-in-patients-with-tophaceous-gout-a-systematic-review
#2
Gretl Lam, Frank L Ross, Ernest S Chiu
GENERAL PURPOSE: To provide information from a review of the literature about chronic ulcers associated with tophaceous gout. TARGET AUDIENCE: This continuing education activity is intended for physicians, physician assistants, nurse practitioners, and nurses with an interest in skin and wound care. LEARNING OBJECTIVES/OUTCOMES: After participating in this educational activity, the participant should be better able to:1. Identify the pathophysiology of tophaceous gout, its presentation, phases, and common comorbidities...
May 2017: Advances in Skin & Wound Care
https://www.readbyqxmd.com/read/28423369/mdi-301-a-synthetic-retinoid-depressed-levels-of-matrix-metalloproteinases-and-oxidative-stress-in-diabetic-dermal-fibroblasts
#3
Jianhua Zhai, Yuli Wang
Diabetic foot ulcerations could result in serious consequences such as amputations. The up-regulation of matrix metalloproteinases and down-regulation of TIMP1 were remarked as distinctive biological characteristics in the diabetic dermal fibroblast. The current study was performed in order to clarify the effect of high glucose on formation of diabetic dermal fibroblast cell. In addition, the effect of MDI 301 on ameliorating diabetic fibroblasts was investigated in this study. The mRNA and protein expression levels of MMPs, TIMP1 and catalase were evaluated against fibroblasts treated with high glucose (30 mM) using qRT-PCR, western blotting and zymography assays...
April 3, 2017: Oncotarget
https://www.readbyqxmd.com/read/28419941/pamam-generation-4-incorporated-gelatin-3d-matrix-as-an-improved-dermal-substitute-for-skin-tissue-engineering
#4
Somnath Maji, Tarun Agarwal, Tapas Kumar Maiti
The study explored the prospects of PAMAM (generation 4) applicability in gelatin based scaffolds for skin tissue engineering. The effect of PAMAM on physico-chemical and biological characteristics of gelatin scaffolds was evaluated. Gelatin scaffolds (with/without PAMAM) were prepared by lyophilization, chemically crosslinked by glutaraldehyde and characterized for their morphology (pore size), chemical features (bond nature), water adsorption, biodegradation and biological compatibility. The study demonstrated that addition of PAMAM did not significantly alter the pore size distribution or porosity of the scaffolds...
April 5, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28417557/a-multitarget-approach-toward-the-development-of-a-new-series-of-8-substituted-purines-for-photoprotection-and-prevention-of-ultra-violet-uv-related-damages
#5
Ernestine Nicaise Djuidje, Valeria Dissette, Alessia Bino, Simonetta Benetti, Jan Balzarini, Sandra Liekens, Stefano Manfredini, Silvia Vertuani, Anna Baldisserotto
In environmental abundance, UV is the most important modifiable risk factor for skin cancer and many other skin diseases such as early photo-aging. Among solar radiation, ultraviolet (UV) is mainly responsible for inducing skin problems. In search of novel photoprotective purines, a new series of 8-substituted purines were synthesized from commercially available 6-hydroxy-4,5-diaminopyrimidine hemisulfate or 4,5-diaminopyrimidine. All the title compounds were investigated for their UV-filter, antioxidant, antifugal and antiproliferative activities...
April 18, 2017: ChemMedChem
https://www.readbyqxmd.com/read/28412341/chitosan-a-potential-biopolymer-for-wound-management
#6
REVIEW
Ijaz Bano, Muhammad Arshad, Tariq Yasin, Muhammad Afzal Ghauri, Muhammad Younus
It has been seen that slow healing and non-healing wounds conditions are treatable but still challenging to humans. Wound dressing usually seeks for biocompatible and biodegradable recipe. Natural polysaccharides like chitosan have been examined for its antimicrobial and healing properties on the basis of its variation in molecular weight and degree of deacetylation. Chitosan adopts some vital characteristics for treatment of various kinds of wounds which include its bonding nature, antifungal, bactericidal and permeability to oxygen...
April 13, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28403359/oral-mucosa-an-alternative-epidermic-cell-source-to-develop-autologous-dermal-epidermal-substitutes-from-diabetic-subjects
#7
Daniela Guzmán-Uribe, Keila Neri Alvarado-Estrada, Mauricio Pierdant-Pérez, Bertha Torres-Álvarez, Jesus Martin Sánchez-Aguilar, Raúl Rosales-Ibáñez
Objective: The aim of this study was to obtain autologous dermal-epidermal skin substitutes from oral mucosa from diabetic subjects as a first step towards a possible clinical application for cases of diabetic foot. Material and Methods: Oral mucosa was obtained from diabetic and healthy subjects (n=20 per group). Epidermal cells were isolated and cultured using autologous fibrin to develop dermal-epidermal in vitro substitutes by the air-liquid technique with autologous human serum as a supplement media...
March 2017: Journal of Applied Oral Science: Revista FOB
https://www.readbyqxmd.com/read/28394544/fibrin-gel-as-a-scaffold-for-skin-substitute-production-and-clinical-experience
#8
(no author information available yet)
The purpose of this study was to create a fibrin-based human skin substitute in vitro with epidermal and dermal component and to assess its healing potential in deep partial and full thickness burns. Fibrin scaff olds were prepared from commercial fibrin glue kits. Human fibroblasts were cultured in fibrin gel. Human keratinocytes were seeded on the top of the gel. Viability of cells was determined fluorimetrically. Scanning electron microscope and immunocytochemistry analysis of cultured cells were performed...
June 2016: Acta Clinica Croatica
https://www.readbyqxmd.com/read/28388010/comparison-of-atmp-gingiva-and-skin-substitutes-and-their-in-vitro-wound-healing-potentials
#9
Mireille A Boink, Sanne Roffel, Melanie Breetveld, Maria Thon, Michiel S P Haasjes, Taco Waaijman, Rik J Scheper, Chantal S Blok, Susan Gibbs
Skin and oral mucosa substitutes are a therapeutic option for closing hard-to-heal skin and oral wounds. Our aim was to develop bi-layered skin and gingiva substitutes, from 3 mm diameter biopsies, cultured under identical conditions, which are compliant with current European regulations for advanced therapy medicinal products. We present in vitro mode of action methods to i) determine viability: epithelial expansion, proliferation (Ki-67), metabolic activity (MTT-assay); ii) characterize skin and gingiva substitutes: histology and immunohistochemistry; and iii) determine potency: soluble wound healing mediator release (ELISA)...
April 7, 2017: Journal of Tissue Engineering and Regenerative Medicine
https://www.readbyqxmd.com/read/28387714/advances-in-skin-regeneration-using-tissue-engineering
#10
REVIEW
Komal Vig, Atul Chaudhari, Shweta Tripathi, Saurabh Dixit, Rajnish Sahu, Shreekumar Pillai, Vida A Dennis, Shree R Singh
Tissue engineered skin substitutes for wound healing have evolved tremendously over the last couple of years. New advances have been made toward developing skin substitutes made up of artificial and natural materials. Engineered skin substitutes are developed from acellular materials or can be synthesized from autologous, allograft, xenogenic, or synthetic sources. Each of these engineered skin substitutes has their advantages and disadvantages. However, to this date, a complete functional skin substitute is not available, and research is continuing to develop a competent full thickness skin substitute product that can vascularize rapidly...
April 7, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28381799/combination-ointment-containing-solid-tranilast-nanoparticles-and-dissolved-sericin-is-efficacious-for-treating-skin-wound-healing-deficits-and-redness-in-diabetic-rats
#11
Noriaki Nagai, Fumihiko Ogata, Saori Deguchi, Akina Ueno, Naohito Kawasaki, Yoshimasa Ito
We attempted to design a combination ointment containing solid tranilast nanoparticles and dissolved sericin as a wound-healing drug (TS-combination ointment), and evaluated its usefulness as therapy for wound-healing deficits in streptozotocin-induced diabetic rat (STZ rat) using kinetic analyses as an index. Solid tranilast nanoparticles were prepared by bead mill methods with low-substituted methylcellulose; the mean particle size of the tranilast nanoparticles was 70 nm. The ointment was designed to contain the tranilast nanoparticles plus sericin powder and/or Carbopol(®) 934...
2017: Biological & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/28375832/fatigue-in-patients-with-systemic-sclerosis-and-hypothyroidism-a-review-of-the-literature-and-report-of-our-experience
#12
Alessandro Antonelli, Poupak Fallahi, Flavia Di Bari, Dilia Giuggioli, Silvia Martina Ferrari, Clodoveo Ferri
Persistent fatigue (defined as ongoing exhaustion, disproportionate to exertion and not adequately alleviated by rest) reduces health-related quality of life of systemic sclerosis (SSc) patients. Fatigue in SSc is associated with reduced capacity to carry out daily activities, work disability and impaired physical function. Clinical studies demonstrated a high prevalence of autoimmune thyroiditis and hypothyroidism in patients with SSc. Since hypothyroidism and the associated fatigue symptoms could be cured by L-thyroxine (L-T4) substitutive therapy, the evolution of fatigue symptoms in SSc hypothyroid patients treated with substitutive therapy has been recently evaluated, showing an amelioration of the fatigue symptoms...
April 4, 2017: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/28372485/a-review-of-cell-based-strategies-for-soft-tissue-reconstruction
#13
Elizabeth A Brett, Natalie Chung, Tripp Leavitt, Arash Momeni, Michael T Longaker, Derrick C Wan
Soft tissue reconstruction to restore volume to damaged or deficient tissue beneath the skin remains a challenging endeavor. Current techniques are centered around autologous fat transfer, or the use of synthetic substitutes, however a great deal of scientific inquiry has been made into both the molecular mechanisms involved in, as well as limitations of, de novo adipogenesis, i.e. the formation of new adipose tissue from precursor cells. To best comprehend these mechanisms, an understanding of defined markers for adipogenic differentiation, as well as knowledge of both commercially available and primary cell lines that enable in vitro and in vivo studies is necessary...
April 3, 2017: Tissue Engineering. Part B, Reviews
https://www.readbyqxmd.com/read/28371727/spreading-properties-of-cosmetic-emollients-use-of-synthetic-skin-surface-to-elucidate-structural-effect
#14
Marine Douguet, Céline Picard, Géraldine Savary, Fabien Merlaud, Nathalie Loubat-Bouleuc, Michel Grisel
The study focuses on the impact of structural and physicochemical properties of emollients on their spreadability. Fifty-three emollients, among which esters, silicones, vegetable and mineral oils, have been characterized. Their viscosity, surface tension, density and spreadability have been measured. Vitro-skin(®), an artificial skin substitute, was used as an artificial porous substrate to measure spreadability. Two different methods have been selected to characterize spreadability, namely contact angle and spreading value...
March 16, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28363294/the-use-of-dermal-skin-substitutes-for-the-treatment-of-the-burned-hand
#15
REVIEW
Ian C Sando, Kevin C Chung
The hand is commonly affected in burn injuries. Joints and extensor tendons are vulnerable given their superficial location. Durable coverage that permits relative frictionless tendon gliding and minimizes scar contracture is required to optimize functional outcomes. When soft tissue donor sites are limited, the use of dermal skin substitutes provides stable coverage with minimal scarring, good mobility, and acceptable appearance. A comprehensive review of dermal skin substitutes and their use with burn reconstruction of the hand is provided...
May 2017: Hand Clinics
https://www.readbyqxmd.com/read/28361280/temporary-skin-grafts-based-on-hybrid-graphene-oxide-natural-biopolymer-nanofibers-as-effective-wound-healing-substitutes-pre-clinical-and-pathological-studies-in-animal-models
#16
N Mahmoudi, N Eslahi, A Mehdipour, M Mohammadi, M Akbari, A Samadikuchaksaraei, A Simchi
In recent years, temporary skin grafts (TSG) based on natural biopolymers modified with carbon nanostructures have received considerable attention for wound healing. Developments are required to improve physico-mechanical properties of these materials to match to natural skins. Additionally, in-deep pre-clinical examinations are necessary to ensure biological performance and toxicity effect in vivo. In the present work, we show superior acute-wound healing effect of graphene oxide nanosheets embedded in ultrafine biopolymer fibers (60 nm) on adult male rats...
May 2017: Journal of Materials Science. Materials in Medicine
https://www.readbyqxmd.com/read/28356487/a-structural-and-functional-analogue-of-a-bowman-birk-type-protease-inhibitor-from-odorranaschmackeri
#17
Yuxin Wu, Qilin Long, Ying Xu, Shaodong Guo, Tianbao Chen, Lei Wang, Mei Zhou, Yingqi Zhang, Chris Shaw, Brian Walker
Frog skin secretions contain complex peptidomes and peptidic protease inhibitors are one of the biologically- and structurally-described groups of components. In this study, by use of molecular "shotgun" cloning and LC MS/MS fractionation sequencing, a novel Bowman Birk-type heptadecapeptide (AALKGCWTKSIPPKPCF-amide), named OSTI, with a canonical Cys(6)-Cys(16) disulfide bridge, was isolated and identified in Piebald Odorous Frog ( Odorrana schmackeri ) skin secretion. A synthetic replicate of OSTI exhibited trypsin inhibitory activity with a Ki value of 0...
March 29, 2017: Bioscience Reports
https://www.readbyqxmd.com/read/28353171/lidocaine-loaded-fish-scale-nanocellulose-biopolymer-composite-microneedles
#18
Pangkhi Medhi, Ololade Olatunji, Atul Nayak, Chandra Teja Uppuluri, Richard T Olsson, Buchi N Nalluri, Diganta B Das
Microneedle (MN) technology has emerged as an effective drug delivery system, and it has tremendous potential as a patient friendly substitute for conventional methods for transdermal drug delivery (TDD). In this paper, we report on the preparation of lidocaine-loaded biodegradable microneedles, which are manufactured from fish scale-derived collagen. Lidocaine, a common tissue numbing anaesthetic, is loaded in these microneedles with an aim of delivering the drug with controlled skin permeation. Evaluation of lidocaine permeation in porcine skin has been successfully performed using Franz diffusion cell (FDC) which has shown that the drug permeation rate increases from 2...
March 28, 2017: AAPS PharmSciTech
https://www.readbyqxmd.com/read/28352157/design-synthesis-and-antimelanogenic-effects-of-2-substituted-phenyl-1-3-dithiolan-4-yl-methanol-derivatives
#19
Do Hyun Kim, Su Jeong Kim, Sultan Ullah, Hwi Young Yun, Pusoon Chun, Hyung Ryong Moon
The authors designed and synthesized 17 (2-substituted phenyl-1,3-dithiolan-4-yl) methanol (PDTM) derivatives to find a new chemical scaffold, showing excellent tyrosinase-inhibitory activity. Their tyrosinase-inhibitory activities were evaluated against mushroom tyrosinase at 50 μM, and five of the PDTM derivatives (PDTM3, PDTM7-PDTM9, and PDTM13) were found to inhibit mushroom tyrosinase more than kojic acid or arbutin, the positive controls. Of seventeen PDTMs, PDTM3 (half-maximal inhibitory concentration 13...
2017: Drug Design, Development and Therapy
https://www.readbyqxmd.com/read/28350864/codon-level-co-occurrences-of-germline-variants-and-somatic-mutations-in-cancer-are-rare-but-often-lead-to-incorrect-variant-annotation-and-underestimated-impact-prediction
#20
Amanda Koire, Young Won Kim, Jarey Wang, Panagiotis Katsonis, Haijing Jin, Olivier Lichtarge
Cancer cells explore a broad mutational landscape, bringing the possibility that tumor-specific somatic mutations could fall in the same codons as germline SNVs and leverage their presence to produce substitutions with a larger impact on protein function. While multiple, temporally consecutive mutations to the same codon have in the past been detected in the germline, this phenomenon has not yet been explored in the context of germline-somatic variant co-occurrences during cancer development. We examined germline context at somatic mutation sites for 1395 patients across four cancer cohorts (breast, skin, colon, and head and neck) and found 392 codon-level co-occurrences between germline and somatic variants, including over a dozen in well-known cancer genes...
2017: PloS One
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