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External tissue expander

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https://www.readbyqxmd.com/read/28202576/differential-effect-of-brief-electrical-stimulation-on-voltage-gated-potassium-channels
#1
Morven Alison Cameron, Amr Al Abed, Yossi Buskila, Socrates Dokos, Nigel H Lovell, John W Morley
Electrical stimulation of neuronal tissue is a promising strategy to treat a variety of neurological disorders. The mechanism of neuronal activation by external electrical stimulation is governed by voltage-gated ion channels. This stimulus, typically brief in nature, leads to membrane potential depolarization, which increases ion flow across the membrane by increasing the open probability of these voltage-gated channels. In spiking neurons, it is activation of voltage-gated sodium channels (NaV-channels) that leads to action potential generation...
February 15, 2017: Journal of Neurophysiology
https://www.readbyqxmd.com/read/28141644/midfacial-changes-through-anterior-maxillary-distraction-osteogenesis-in-patients-with-cleft-lip-and-palate
#2
Hiroyuki Kanzaki, Yoshimichi Imai, Tetsu Nakajo, Takayoshi Daimaruya, Akimitsu Sato, Masahiro Tachi, Youhei Nunomura, Yusuke Itagaki, Kazuaki Nishimura, Shoko Kochi, Kaoru Igarashi
Maxillary hypoplasia is a major issue in cleft lip and palate patients, and predictable surgical maxillary advancement is required. In the present study, the changes and stability of the maxilla and soft tissue profile achieved after the application of anterior maxillary distraction osteogenesis (AMDO) using intraoral expander in unilateral cleft lip and palate and isolated cleft palate patients were investigated by comparing to the Le Fort I osteotomy (LFI) and maxillary distraction osteogenesis (DO) with rigid external distraction (RED) system...
January 30, 2017: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/28092336/the-construction-of-expanded-prefabricated-adipose-tissue-epat-using-an-external-volume-expansion-eve-device
#3
Yi Yuan, Shuifa Yang, Yangyan Yi, Jianhua Gao, Feng Lu
BACKGROUND: Multiple studies have demonstrated that mechanical forces promote the growth of adipose tissue. However, the mechanism of adipose tissue regeneration induced by mechanical forces remains unclear. METHODS: In an experiment using rats, prefabricated adipose tissue with a vessel pedicle was expanded using an external volume expansion (EVE) device. The volume of fat flaps was tested at different time points. Cell proliferation and angiogenesis were analyzed using immunofluorescence...
January 12, 2017: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/28070593/-morphological-investigations-of-deep-sole-ulcers-in-cattle-part-1-the-complicated-rusterholz-ulcer
#4
Susanne Gehringer, Matthias Müller, Johann Maierl
OBJECTIVE: In the context of a larger study on morphological changes of deep sole ulcers, claws with Rusterholz ulcer (RU) were investigated to describe the varied pathological changes of the RU. MATERIAL AND METHODS: Hind limbs of 55 cows displaying external signs of complicated sole ulcers were examined externally and internally. To examine the samples internally, a sagittal section was performed. Furthermore, the material was examined histologically and after bone maceration...
February 9, 2017: Tierärztliche Praxis. Ausgabe G, Grosstiere/Nutztiere
https://www.readbyqxmd.com/read/28047553/su-f-t-686-considerations-about-dose-protraction-factor-in-tcp-calculations-for-prostate-vmat-treatments
#5
F Clemente, C Perez-Vara, M Clavo
PURPOSE: Dose protraction factor should be considered in order to model the TCP calculations. Nevertheless, this study describes a brief discussion showing that the lack of its inclusion should not invalidate these calculations for prostate VMAT treatments. METHODS: Dose protraction factor (G) modifies the quadratic term of the linear-quadratic expression in order to take into account the sublethal damage repair of protracting the dose delivery. If the delivery takes a short time (instantaneous), G = 1...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28035642/interactions-of-calcium-with-the-external-surfaces-of-fullerenes-and-endofullerenes-doped-with-radioactive-sodium-iodide
#6
Alejandro Valderrama, Radamés Reynoso, Raúl W Gómez, Vivianne Marquina, Martín Romero
We report first-principles calculations carried out to analyze the adsorption of calcium on the outer surface of the fullerene C60, yielding [C60 + mCa]. Geometric optimization (GO) and molecular dynamics (MD) simulation were performed using the plane-wave pseudopotential method within the framework of density functional theory (DFT) and time-dependent DFT (TD-DFT) to investigate the configurations, the associated energies in the ground state, and the stabilities of fullerenes and endofullerenes doped with radioactive sodium iodide when they interact with calcium atoms on the outer fullerene surface (i...
January 2017: Journal of Molecular Modeling
https://www.readbyqxmd.com/read/27995490/hydrogel-tissue-expanders-for-stomatology-part-i-methacrylate-based-polymers
#7
Jakub Hrib, Jakub Sirc, Petr Lesny, Radka Hobzova, Miroslava Duskova-Smrckova, Jiri Michalek, Roman Smucler
In order to create a soft tissue surplus, implantable volume expanders are often utilized in dental surgery. Implanted tissue expanders should gradually increase their volume, exerting a constant pressure on the surrounding tissue for weeks. Current tissue expanders are based predominantly on externally inflatable balloons or on osmotically active tissue expanders that use soft hydrogels wrapped in perforated plastic coatings, which limit fluid entry and swelling. We have designed and examined tissue expanders based on the controlled rate expansive hydrogels synthesized from copolymers of selected methacrylates and N-vinylpyrrolidone, cross-linked with a combination of non-degradable (glycol dimethacrylates) and hydrolytically degradable (N,O-dimethacryloylhydroxylamine) cross-linkers...
January 2017: Journal of Materials Science. Materials in Medicine
https://www.readbyqxmd.com/read/27845495/unicellular-but-not-asocial-life-in-community-of-a-bacterium
#8
Diego Romero
All living organisms have acquired the outstanding ability to overcome the limitations imposed by changeable environments through the gain of genetic traits over years of evolution and the tendency of individuals to associate in communities. The complementation of a singular weakness, the deployment of reinforcement for the good of the community, the better use of resources, or effective defense against external aggression are advantages gained by this communal behavior. Communication has been the cohesive element prompting the global responses that promote efficiency in two features of any community: specialization in differentiated labor and the spatio-temporal organization of the environment...
June 2016: International Microbiology: the Official Journal of the Spanish Society for Microbiology
https://www.readbyqxmd.com/read/27769375/species-specific-isotope-dilution-for-the-accurate-and-si-traceable-determination-of-arsenobetaine-and-methylmercury-in-cuttlefish-and-prawn
#9
Paramee Kumkrong, Benjaporn Thiensong, Phuong Mai Le, Garnet McRae, Anthony Windust, Suladda Deawtong, Juris Meija, Paulette Maxwell, Lu Yang, Zoltán Mester
Methods based on species specific isotope dilution were developed for the accurate and SI traceable determination of arsenobetaine (AsBet) and methylmercury (MeHg) in prawn and cuttlefish tissues by LC-MS/MS and SPME GC-ICPMS. Quantitation of AsBet and MeHg were achieved by using a (13)C-enriched AsBet spike (NRC CRM CBET-1) and an enriched spike of Me(198)Hg (NRC CRM EMMS-1), respectively, wherein analyte mass fractions in enriched spikes were determined by reverse isotope dilution using natural abundance AsBet and MeHg primary standards...
November 2, 2016: Analytica Chimica Acta
https://www.readbyqxmd.com/read/27740954/reconstruction-of-complex-groin-defects-after-sarcoma-resection
#10
Shimpei Miyamoto, Masahide Fujiki, Fumihiko Nakatani, Eisuke Kobayashi, Masanobu Sakisaka, Minoru Sakuraba
BACKGROUND: Complex groin defects after sarcoma resection require reconstruction of multiple vital structures that can include the major vessels, the overlying skin, the abdominal wall, and the hip joint. We investigated the feasibility of limb preservation after complex groin reconstruction. METHODS: The subjects were 12 consecutive patients who underwent complex groin reconstruction after sarcoma resection. In all patients, the defect included a major artery (external iliac or femoral) and overlying skin...
October 6, 2016: Annals of Plastic Surgery
https://www.readbyqxmd.com/read/27689056/a-simple-reliable-and-inexpensive-intraoperative-external-expansion-system-for-enhanced-autologous-structural-fat-grafting
#11
Carlo M Oranges, Mathias Tremp, Barbara Ling, Reto Wettstein, René D Largo, Dirk J Schaefer
External volume expansion of the recipient site by suction has been proposed as a way of improving fat graft survival. The objective of this study was to present an innovative and simple intraoperative external expansion system to enhance small-volume autologous fat grafting (40-80 mL) and to discuss its background and its mechanism of action. In this system, expansion is performed using a complete vacuum delivery system known as the Kiwi VAC-6000M with a PalmPump (Clinical Innovations). The recipient site is rapidly expanded intraoperatively 10 times for 30 seconds each with a negative pressure of up to 550 mm Hg before autologous fat injection...
September 2016: Archives of Plastic Surgery
https://www.readbyqxmd.com/read/27570784/biomechanical-evaluation-of-posterior-cruciate-ligament-reconstruction-with-quadriceps-versus-achilles-tendon-bone-block-allograft
#12
Brian Forsythe, Marc S Haro, Ljiljana Bogunovic, Michael J Collins, Thomas A Arns, Katie J Trella, Elizabeth F Shewman, Nikhil N Verma, Bernard R Bach
BACKGROUND: Long-term studies of posterior cruciate ligament (PCL) reconstruction suggest that normal stability is not restored in the majority of patients. The Achilles tendon allograft is frequently utilized, although recently, the quadriceps tendon has been introduced as an alternative option due to its size and high patellar bone density. PURPOSE/HYPOTHESIS: The purpose of this study was to compare the biomechanical strength of PCL reconstructions using a quadriceps versus an Achilles allograft...
August 2016: Orthopaedic Journal of Sports Medicine
https://www.readbyqxmd.com/read/27566509/characterization-of-pediatric-microtia-cartilage-a-reservoir-of-chondrocytes-for-auricular-reconstruction-using-tissue-engineering-strategies
#13
Y Melgarejo-Ramírez, R Sánchez-Sánchez, J García-López, A M Brena-Molina, C Gutiérrez-Gómez, C Ibarra, C Velasquillo
The external ear is composed of elastic cartilage. Microtia is a congenital malformation of the external ear that involves a small reduction in size or a complete absence. The aim of tissue engineering is to regenerate tissues and organs clinically implantable based on the utilization of cells and biomaterials. Remnants from microtia represent a source of cells for auricular reconstruction using tissue engineering. To examine the macromolecular architecture of microtia cartilage and behavior of chondrocytes, in order to enrich the knowledge of this type of cartilage as a cell reservoir...
September 2016: Cell and Tissue Banking
https://www.readbyqxmd.com/read/27565067/flap-preconditioning-by-pressure-controlled-cupping-in-a-rat-model
#14
Kyung S Koh, Sung Woo Park, Tae Suk Oh, Jong Woo Choi
BACKGROUND: Flap survival is essential for the success of soft-tissue reconstruction. Accordingly, various surgical and medical methods aim to increase flap survival. Because flap survival is affected by the innate vascular supply, traditional preconditioning methods mainly target vasodilatation or vascular reorientation to increase blood flow to the tissue. External stress on the skin, such as an external volume expander or cupping, induces vascular remodeling, and these approaches have been used in the fat grafting field and in traditional Asian medicine...
August 2016: Journal of Surgical Research
https://www.readbyqxmd.com/read/27558401/is-cancer-a-severe-delayed-hypersensitivity-reaction-and-histamine-a-blueprint
#15
Mahin Khatami
Longevity and accumulation of multiple context-dependent signaling pathways of long-standing inflammation (antigen-load or oxidative stress) are the results of decreased/altered regulation of immunity and loss of control switch mechanisms that we defined as Yin and Yang of acute inflammation or immune surveillance. Chronic inflammation is initiated by immune disruptors-induced progressive changes in physiology and function of susceptible host tissues that lead to increased immune suppression and multistep disease processes including carcinogenesis...
December 2016: Clinical and Translational Medicine
https://www.readbyqxmd.com/read/27536498/initial-experience-using-closed-incision-negative-pressure-therapy-after-immediate-postmastectomy-breast-reconstruction
#16
Allen Gabriel, Steven R Sigalove, G Patrick Maxwell
Although immediate postmastectomy breast reconstruction is favored over delayed reconstruction, it remains associated with high complication rates. Potential complications include seroma formation, dehiscence, infection, and tissue necrosis along incision edges. Closed incision negative pressure therapy (ciNPT; Prevena Incision Management System, KCI, an Acelity company, San Antonio, Tex.) has been reported to help hold incision edges together, protect incisions from external contamination, and remove fluid and infectious material...
July 2016: Plastic and Reconstructive Surgery. Global Open
https://www.readbyqxmd.com/read/27436073/future-targets-for-female-sexual-dysfunction
#17
Melissa Farmer, Hana Yoon, Irwin Goldstein
INTRODUCTION: Female sexual function reflects a dynamic interplay of central and peripheral nervous, vascular, and endocrine systems. The primary challenge in the development of novel treatments for female sexual dysfunction is the identification and targeted modulation of excitatory sexual circuits using pharmacologic treatments that facilitate the synthesis, release, and/or receptor binding of neurochemicals, peptides, and hormones that promote female sexual function. AIM: To develop an evidence-based state-of-the-art consensus report that critically integrates current knowledge of the therapeutic potential for known molecular and cellular targets to facilitate the physiologic processes underlying female sexual function...
August 2016: Journal of Sexual Medicine
https://www.readbyqxmd.com/read/27304222/does-undersizing-of-transcatheter-aortic-valve-bioprostheses-during-valve-in-valve-implantation-avoid-coronary-obstruction-an-in-vitro-study
#18
Sina Stock, Michael Scharfschwerdt, Roza Meyer-Saraei, Doreen Richardt, Efstratios I Charitos, Hans-Hinrich Sievers, Thorsten Hanke
Background The transcatheter aortic valve-in-valve implantation (TAViVI) is an evolving treatment strategy for degenerated surgical aortic valve bioprostheses (SAVBs) in patients with high operative risk. Although hemodynamics is excellent, there is some concern regarding coronary obstruction, especially in SAVB with externally mounted leaflet tissue, such as the Trifecta (St. Jude Medical Inc., St. Paul, Minnesota, United States). We investigated coronary flow and hydrodynamics before and after TAViVI in a SAVB with externally mounted leaflet tissue (St...
June 15, 2016: Thoracic and Cardiovascular Surgeon
https://www.readbyqxmd.com/read/27284527/simple-1-step-ankle-arthroscopy-distraction
#19
Alicia Unangst, Kevin D Martin
Ankle arthroscopy has emerged as a viable treatment option for multiple ankle pathologies and continues to have expanding indications as technology and techniques improve. Historically, ankle arthroscopy used skeletal traction, and it has transitioned to noninvasive soft-tissue distraction because of high rates of iatrogenic complications. Although soft-tissue distraction has decreased complications, it continues to be both cumbersome and time-consuming. Thus we propose a 1-step simple ankle arthroscopy distraction technique that uses an external positioning arm to allow the surgeon to apply manual traction in multiple positions without the use of any reprocessed sterile equipment...
December 2015: Arthroscopy Techniques
https://www.readbyqxmd.com/read/27200202/osseointegrated-implants-an-alternative-approach-in-patients-with-bilateral-auricular-defects-due-to-chemical-assault
#20
Emilio Mevio, Mauro Mullace, Luca Facca, Stefano Schettini
Acid attacks committed as crimes of passion are unfortunately becoming far from infrequent occurrence. The injuries sustained in such attacks mainly involve the face and trunk, with the acid causing cutaneous and subcutaneous tissue burns that can result in permanent scarring, loss of the nose or external ear, and severe visual impairment. Different surgical solutions have been proposed for reconstruction of the auricle following loss of the ear through traumatic injury or cancer or in patients with congenital defects: surgical reconstruction may involve the insertion of an autogenous rib cartilage framework or the use of a porous polymer material inserted into an expanded postauricular flap...
2016: Case Reports in Otolaryngology
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