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Dehydrated amniotic tissue

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https://www.readbyqxmd.com/read/28224047/identification-of-extracellular-matrix-components-and-biological-factors-in-micronized-dehydrated-human-amnion-chorion-membrane
#1
Jennifer Lei, Lauren B Priddy, Jeremy J Lim, Michelle Massee, Thomas J Koob
Objective: The use of bioactive extracellular matrix (ECM) grafts such as amniotic membranes is an attractive treatment option for enhancing wound repair. In this study, the concentrations, activity, and distribution of matrix components, growth factors, proteases, and inhibitors were evaluated in PURION(®) Processed, micronized, dehydrated human amnion/chorion membrane (dHACM; MiMedx Group, Inc.). Approach: ECM components in dHACM tissue were assessed by using immunohistochemical staining, and growth factors, cytokines, proteases, and inhibitors were quantified by using single and multiplex ELISAs...
February 1, 2017: Advances in Wound Care
https://www.readbyqxmd.com/read/27410471/treatment-of-diabetic-foot-ulcers-with-dehydrated-amniotic-membrane-allograft-a-prospective-case-series
#2
R J Abdo
OBJECTIVE: A diabetic foot ulcer (DFU) is one of the many potential complications associated with diabetes. If not effectively and rapidly treated, DFUs can result in lower extremity amputations. This prospective case series aimed to assess the effectiveness of a dehydrated amniotic-derived tissue allograft (DAMA), with regards to time to wound closure and total number of applications. METHOD: Patients were recruited with a neuropathic non-healing DFU(s) despite standard care for at least 4 weeks before the study...
July 2016: Journal of Wound Care
https://www.readbyqxmd.com/read/27267629/transparent-resilient-human-amniotic-membrane-laminates-for-corneal-transplantation
#3
Takehiro Hariya, Yuji Tanaka, Shunji Yokokura, Toru Nakazawa
This study evaluated a new technique to toughen and optically clarify human amniotic membrane (AM) tissue, which is naturally thin and clouded, and determined the suitability of the altered tissue for corneal transplantation. The technique created a tissue laminate by repeatedly depositing wet layers of AM and dehydrating them, followed by chemical cross-linking to tighten integration at the layer interfaces and within the layers, thereby improving the physical properties of the laminates by increasing light transmittance and mechanical strength...
September 2016: Biomaterials
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