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Cervical cancer screening

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https://www.readbyqxmd.com/read/27906806/awareness-of-cervical-cancer-causes-and-predeterminants-of-likelihood-to-screen-among-women-in-haiti
#1
Schatzi H McCarthy, Kathy A Walmer, Joel C Boggan, Margaret W Gichane, William A Calo, Harry A Beauvais, Noel T Brewer
OBJECTIVES: Cervical cancer is the leading cause of cancer deaths among women in Haiti. Given this high disease burden, we sought to better understand women's knowledge of its causes and the sociodemographic and health correlates of cervical cancer screening. MATERIALS AND METHODS: Participants were 410 adult women presenting at clinics in Léogâne and Port-au-Prince, Haiti. We used bivariate and multivariate logic regression to identify correlates of Pap smear receipt...
November 30, 2016: Journal of Lower Genital Tract Disease
https://www.readbyqxmd.com/read/27905473/carcinogenic-human-papillomavirus-infection
#2
Mark Schiffman, John Doorbar, Nicolas Wentzensen, Silvia de Sanjosé, Carole Fakhry, Bradley J Monk, Margaret A Stanley, Silvia Franceschi
Infections with human papillomavirus (HPV) are common and transmitted by direct contact. Although the great majority of infections resolve within 2 years, 13 phylogenetically related, sexually transmitted HPV genotypes, notably HPV16, cause - if not controlled immunologically or by screening - virtually all cervical cancers worldwide, a large fraction of other anogenital cancers and an increasing proportion of oropharyngeal cancers. The carcinogenicity of these HPV types results primarily from the activity of the oncoproteins E6 and E7, which impair growth regulatory pathways...
December 1, 2016: Nature Reviews. Disease Primers
https://www.readbyqxmd.com/read/27904404/phenolic-composition-antioxidant-capacity-and-in-vitro-cytotoxicity-assessment-of-fruit-wines
#3
Ana Ljevar, Natka Ćurko, Marina Tomašević, Kristina Radošević, Višnja Gaurina Srček, Karin Kovačević Ganić
Fruit wines contain a wide range of phenolic compounds with biological effects, but their composition and potential benefits to human health have been studied to the much lesser extent compared to grape wines. The aim of this research is to study the phenolic profile of different types of fruit wines and to evaluate their antioxidant and biological potential. Commercially available fruit wines from blackberry, cherry, raspberry, blackcurrant, strawberry and apple produced in Croatia were analyzed. To the best of our knowledge, this study represents the first comprehensive screening of Croatian fruit wines...
June 2016: Food Technology and Biotechnology
https://www.readbyqxmd.com/read/27900660/increasing-breast-and-cervical-cancer-screening-in-rural-and-border-texas-with-friend-to-friend-plus-patient-navigation
#4
Derek Falk, Catherine Cubbin, Barbara Jones, Kristen Carrillo-Kappus, Andrew Crocker, Carol Rice
The Friend to Friend plus Patient Navigation Program (FTF+PN) aims to build an effective, sustainable infrastructure to increase breast and cervical screening rates for underserved women in rural Texas. The objective of this paper is to identify factors that (1) distinguish participants who chose patient navigation (PN) services from those who did not (non-PN) and (2) were associated with receiving a mammogram or Papanicolaou (Pap) test. This prospective study analyzed data collected from 2689 FTF+PN participants aged 18-99 years from March 1, 2012 to February 28, 2015 who self-identified as African American (AA), Latina, and non-Hispanic white (NHW)...
November 29, 2016: Journal of Cancer Education: the Official Journal of the American Association for Cancer Education
https://www.readbyqxmd.com/read/27894911/personal-and-provider-level-factors-influence-participation-to-cervical-cancer-screening-a-retrospective-register-based-study-of-1-3-million-women-in-norway
#5
Maarit K Leinonen, Suzanne Campbell, Ole Klungsøyr, Stefan Lönnberg, Bo T Hansen, Mari Nygård
High coverage is essential for an effective screening programme. Here we present screening barriers and facilitators among 1.3 million women aged 25-69years eligible for screening within the Norwegian Cervical Cancer Screening Program (NCCSP). We defined non-adherence as no screening test in 2008-2012. We divided adherent women into those screened spontaneously, and those who had a smear after receiving a reminder from the NCCSP. Explanatory variables were extracted from several nationwide registers, and modelled by modified Poisson regression...
November 25, 2016: Preventive Medicine
https://www.readbyqxmd.com/read/27894910/cervical-cancer-screening-in-women-vaccinated-against-human-papillomavirus-infection-recommendations-from-a-consensus-conference
#6
Paolo Giorgi Rossi, Francesca Carozzi, Antonio Federici, Guglielmo Ronco, Marco Zappa, Silvia Franceschi
In Italy, the cohorts of women who were offered Human papillomavirus (HPV) vaccination in 2007/08 will reach the age for cervical cancer (CC) screening from 2017. The simultaneous shift from cytology-based screening to HPV test-based screening gives the opportunity for unprecedented reorganisation of CC prevention. The ONS (National Screening Monitoring Centre) Directive and the GISCi (Italian Group for Cervical Screening) identified the consensus conference as the most suitable method for addressing this topic...
November 25, 2016: Preventive Medicine
https://www.readbyqxmd.com/read/27894752/trends-in-cervical-cancer-incidence-in-younger-us-women-from-2000-to-2013
#7
Daniel C Beachler, Joseph E Tota, Michelle I Silver, Aimée R Kreimer, Allan Hildesheim, Nicolas Wentzensen, Mark Schiffman, Meredith S Shiels
OBJECTIVE: This study aimed to assess the temporal trends in invasive cervical cancer (ICC) incidence rates among 21-25year-olds. US guidelines no longer recommend screening prior to age 21, and concerns have been raised that delayed screening initiation may increase ICC incidence among young women. METHODS: This study utilized ICC incidence data from 18 US population-based cancer registries in SEER from 2000 to 2013 and Pap test prevalence data from the Behavioral Risk Factor Surveillance System from 1996 to 2012...
November 25, 2016: Gynecologic Oncology
https://www.readbyqxmd.com/read/27894347/estimation-of-utility-weights-for-human-papilloma-virus-related-health-states-according-to-disease-severity
#8
Minsu Ock, Jeong-Yeol Park, Woo-Seung Son, Hyeon-Jeong Lee, Seon-Ha Kim, Min-Woo Jo
BACKGROUND: A cost-utility study of a human papilloma virus (HPV) vaccine requires that the utility weights for HPV-related health states (i.e., cervical intraepithelial neoplasia (CIN), cervical cancer, and condyloma) be evaluated. The aim of the present study was to determine the utility weights for HPV-related health states. METHODS: Hypothetical standardised health states related to HPV were developed based on patient education material and previous publications...
November 28, 2016: Health and Quality of Life Outcomes
https://www.readbyqxmd.com/read/27894291/hpv-prevalence-in-the-dutch-cervical-cancer-screening-population-dusc-study-hpv-testing-using-automated-hc2-cobas-and-aptima-workflows
#9
Cornelis Johannes Jacobus Huijsmans, Willemina Rosalia Rita Geurts-Giele, Cindy Leeijen, Hendrikus Lambertus Cornelius Maria Hazenberg, Jenneke van Beek, Carola de Wild, Johannes Cornelis van der Linden, Adrianus Johannes Christiaan van den Brule
BACKGROUND: Primary high risk (hr)HPV screening will be introduced in The Netherlands in January 2017. Our aim was to determine the hrHPV prevalence in the Dutch cervical cancer screening population (DuSC study). METHODS: A total of 12,113 residual PreservCyt cervical samples from the Dutch population based cytology screening program were rendered anonymous, randomized and tested for hrHPV using 3 HPV assays on their respective automated platforms: QIAGEN's digene® HC2 HPV DNA Test® (HC2, signal amplification), Roche Cobas® HPV test (DNA amplification) and Hologic Aptima® HPV Test (RNA amplification)...
November 28, 2016: BMC Cancer
https://www.readbyqxmd.com/read/27891686/implementation-of-a-real-time-reference-and-calibration-grid-platform-for-improved-screening-mapping-in-pap-test-slides
#10
Evangelos Tsiambas, Christos Riziotis
Cervical cancer screening based on the Papanicolaou (Pap) test is a widely applied but not always efficient practice for detecting Human Papillomavirus (HPV) mediated lesions, partially due to a non-systematic and inadequate screening process. Our aim was to introduce an inexpensive easy-to-use direct screening platform for improved detection of abnormal cells indicative of underlying cervical neoplasia as well as persisting HPV infection. By employing a novel, efficient technique of laser-based micromachining, we achieved the fabrication of spatial grids on commercially available coverslips allowing visual segmentation of the slide for efficient screening...
November 27, 2016: Pathology International
https://www.readbyqxmd.com/read/27891533/screening-for-cancer-in-persons-living-with-hiv-infection
#11
James J Goedert, H Dean Hosgood, Robert J Biggar, Howard D Strickler, Charles S Rabkin
Survival with human immunodeficiency virus (HIV) infection has greatly improved due to effective antiretroviral therapy (ART). As infectious complications have declined, malignancy now accounts for over one-third of deaths among people living with HIV (PLWH). Based on practices in the general population, cancer screening of PLWH can decrease both morbidity and mortality. In this article, we review and consider directed approaches for colorectal, breast, cervical and lung cancer screening. Furthermore, routine physical examinations may detect lymphomas and skin, anal and oral cancers...
August 2016: Trends in Cancer
https://www.readbyqxmd.com/read/27889456/synthesis-of-new-morpholine-connected-pyrazolidine-derivatives-and-their-antimicrobial-antioxidant-and-cytotoxic-activities
#12
Radhakrishnan Surendra Kumar, Meera Moydeen, Salem S Al-Deyab, Aseer Manilal, Akbar Idhayadhulla
A simple and convenient one-pot four-component synthesis of morpholine-connected pyrazolidine derivatives 2a-f and 4a-f was developed using direct metal-free catalysis, with the identities of the synthesized compounds confirmed by IR, NMR ((1)H and (13)C), mass spectrometry, and elemental analysis. The prepared compounds were inspected for antimicrobial, antioxidant, and cytotoxic activities. Antimicrobial and antifungal activities against five bacterial and four fungal pathogens, respectively, were investigated using the disc diffusion technique...
November 14, 2016: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/27886949/why-do-chilean-women-choose-to-have-or-not-have-pap-tests
#13
Maria-Teresa Urrutia, Alejandra Araya, Maria-Fernanda Jaque
OBJECTIVE: To describe the perceptions of Chilean women about why women choose to have or not have Pap test screening. DESIGN: Qualitative research using content analysis according to Krippendorf. SETTING: Data were gleaned from 57 Chilean women from a public primary care clinic who participated in an audiotaped focus group. RESULTS: Six themes emerged: Reasons that make it difficult for women schedule an appointment, Characteristics of health professionals that make it difficult to have a Pap test, Characteristics of the test that are barriers to having a Pap test, The relationship of the test with cancer, Family context, and Each woman's personal characteristics...
November 22, 2016: Journal of Obstetric, Gynecologic, and Neonatal Nursing: JOGNN
https://www.readbyqxmd.com/read/27885306/impact-of-a-national-cancer-prevention-and-treatment-program-on-the-prevalence-of-late-stage-breast-cancer-diagnoses-in-oklahoma
#14
Amanda Janitz, Aaron M Wendelboe, Ann F Chou, Summer Frank, Angela Watkins, David Thompson, Janis Campbell
In 2000, Congress passed the Breast and Cervical Cancer Prevention and Treatment Act (BCCPTA) to provide coverage through Medicaid to women who screened positive for breast and cervical cancer. We aimed to determine if late-stage breast cancer prevalence decreased among Oklahoma women after passage of BCCPTA. Data were obtained from the Oklahoma Central Cancer Registry during 2000-2011. We estimated prevalence proportion ratios (PPR) using modified Poisson regression between the proportion of women with late-stage breast cancer and timing of diagnosis related to BCCPTA...
July 2016: Journal of the Oklahoma State Medical Association
https://www.readbyqxmd.com/read/27882128/microrna-145-sensitizes-cervical-cancer-cells-to-low-dose-irradiation-by-downregulating-oct4-expression
#15
Siqi Yan, Xiangjun Li, Qiao Jin, Jun Yuan
Poor elucidation of the mechanisms involved in regulating the radiosensitivity of cancers prevents the extensive application of low-dose radiotherapy in clinical settings. The present study was conducted to investigate the role of microRNA-145 (miR-145) in the modulation of cervical cancer cell radiosensitivity, as well as to identify the underlying target of miR-145 during this process. Cervical cancer tera cells were initially exposed to doses of radiation between 1 and 6 Gy before the assessments of the cell viability and apoptosis rate...
November 2016: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/27881528/life-course-socioeconomic-status-and-breast-and-cervical-cancer-screening-analysis-of-the-who-s-study-on-global-ageing-and-adult-health-sage
#16
Tomi Akinyemiju, Kemi Ogunsina, Swati Sakhuja, Valentine Ogbhodo, Dejana Braithwaite
OBJECTIVES: Socioeconomic differences in screening have been well documented in upper-income countries; however, few studies have examined socioeconomic status (SES) over the life-course in relation to cancer screening in lower-income and middle-income countries. Here, we examine individual, parental and life-course SES differences in breast and cervical cancer screening among women in India, China, Mexico, Russia and South Africa. SETTING: Data from the WHO's Study on Global Ageing and Adult Health (SAGE) 2007-2008 data were used for survey-weighted multivariable regression analysis...
November 22, 2016: BMJ Open
https://www.readbyqxmd.com/read/27881522/prevalence-of-papillomavirus-in-brazil-a-systematic-review-protocol
#17
Verônica Colpani, Augusto Bacelo Bidinotto, Maicon Falavigna, Silvana Pereira Giozza, Adele Schwartz Benzaken, Cristina Pimenta, Ana Goretti Kalume Maranhão, Carla Magda Allan Santos Domingues, Luciano Serpa Hammes, Eliana M Wendland
INTRODUCTION: Human papillomavirus (HPV) infection is a cause of premalignant and malignant cancer in the lower genital and digestive tracts. In Brazil, there have been no prevalence studies that included a nationwide sample, and the prevalence of HPV has not been determined in many regions. METHODS: We will search the EMBASE, LILACS, MEDLINE, Web of Science and SciELO databases and previously published review articles to identify original research articles assessing HPV prevalence of the perineal (cervical, penile and anal) and oral areas...
November 22, 2016: BMJ Open
https://www.readbyqxmd.com/read/27881270/cost-effectiveness-of-screening-and-treatment-for-cervical-cancer-in-tanzania-implications-for-other-sub-saharan-african-countries
#18
Stephanie Nelson, Jungyoon Kim, Fernando A Wilson, Amr S Soliman, Twalib Ngoma, Crispin Kahesa, Julius Mwaiselage
OBJECTIVES: To compare the institutional cost per person of screening and treatment between two groups of patients-those screened and those not screened before treatment for cervical cancer at Ocean Road Cancer Institute (ORCI) in Dar es Salaam, Tanzania-and to perform a cost-effectiveness analysis of the ORCI cervical cancer screening program. METHODS: The study included 721 screened and 333 unscreened patients treated at ORCI for cervical cancer from 2002 to 2011...
September 2016: Value in Health Regional Issues
https://www.readbyqxmd.com/read/27881267/cost-utility-analysis-of-human-papillomavirus-vaccination-and-cervical-screening-on-cervical-cancer-patient-in-indonesia
#19
Didik Setiawan, Franklin Christiaan Dolk, Auliya A Suwantika, Tjalke Arend Westra, Jan C WIlschut, Maarten Jacobus Postma
BACKGROUND: Although cervical cancer is a preventable disease, the clinical and economic burdens of cervical cancer are still substantial issues in Indonesia. OBJECTIVES: The main purpose of this study was to model the costs, clinical benefits, and cost-utility of both visual inspection with acetic acid (VIA) screening alone and human papillomavirus (HPV) vaccination in addition to VIA screening in Indonesia. METHODS: We developed a population-based Markov model, consisting of three health states (susceptible, cervical cancer, and death), to assess future costs, health effects, and the cost-utility of cervical cancer prevention strategies in Indonesia...
May 2016: Value in Health Regional Issues
https://www.readbyqxmd.com/read/27881082/quality-assurance-of-human-papillomavirus-hpv-testing-in-the-implementation-of-hpv-primary-screening-in-norway-an-inter-laboratory-reproducibility-study
#20
Birgit Engesæter, Bianca van Diermen Hidle, Mona Hansen, Pia Moltu, Kjersti Mangseth Staby, Siri Borchgrevink-Persen, Olav K Vintermyr, Stefan Lönnberg, Mari Nygård, Emiel A M Janssen, Philip E Castle, Irene Kraus Christiansen
BACKGROUND: Human papillomavirus (HPV) testing as primary screening for cervical cancer is currently being implemented in Norway in a randomized controlled fashion, involving three laboratories. As part of the quality assurance programme of the implementation, an evaluation of the inter-laboratory reproducibility of the HPV test was initiated, to ensure satisfactory HPV test reliability in all three laboratories. METHODS: The HPV test used is the cobas 4800 HPV Test, detecting 14 high-risk types with individual HPV genotype results for HPV16 and HPV18...
November 24, 2016: BMC Infectious Diseases
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