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Cervical cancer screening

John K Chan, Stephanie Chow, Subasish Bhowmik, Amandeep Mann, Daniel S Kapp, Robert L Coleman
Gynecologic cancers comprise of mostly uterine, ovarian, and cervical malignancies and are responsible for 95,000 new cases annually in the United States. Uterine cancer is the most common and the number of new cases and mortality has been increasing. Cervical cancer has decreased due to screening, early detection, and treatment of pre-invasive cancers. However, ovarian cancer remains the most lethal because of advanced stage at diagnosis and drug resistance. The metastatic spread pattern differs amongst these cancers, with uterine and cervical cancer found mostly in the primary organ and ovarian cancer disseminating throughout the peritoneum and upper abdomen at presentation...
June 21, 2018: Clinical & Experimental Metastasis
Erika L Thompson, Christopher W Wheldon, Cheryl A Vamos, Stacey B Griner, Ellen M Daley
While Pap testing has significantly reduced the burden of cervical cancer, not all women follow prevention recommendations of cervical cancer screening every 3 years. Health literacy regarding Pap testing may influence the adoption of this behavior. The objective of this study was to assess the health literacy-related factors associated with Pap testing among a nationally representative sample of women in the USA. The Health Information National Trends Survey Cycles 4.4 and 5.1 were restricted to women 21-65 years of age (N = 2992)...
June 21, 2018: Journal of Cancer Education: the Official Journal of the American Association for Cancer Education
Sze Chuen Cesar Wong, Thomas Chi Chuen Au, Sammy Chung Sum Chan, Lawrence Po Wah Ng, Hin Fung Tsang
Background: Human papillomavirus (HPV) is a known causative factor in the etiology of cervical cancer. Methods: HPV DNA genotyping was performed in menstrual blood (MB) collected in napkins from patients with cervical intraepithelial neoplasia (CIN), HPV infection and sexually active apparently normal subjects. In the same patient cohort, MB TAP1 I333V and TAP1 D637G gene polymorphisms were examined. Results: The sensitivity, specificity, positive and negative predictive values of HPV DNA to detect CIN or HPV infection was 83% (223/268), 98% (131/134), 99% (223/226) and (74%) 131/176, respectively...
June 19, 2018: Journal of Infectious Diseases
Iris Babion, Barbara C Snoek, Putri W Novianti, Annelieke Jaspers, Nienke van Trommel, Daniëlle A M Heideman, Chris J L M Meijer, Peter J F Snijders, Renske D M Steenbergen, Saskia M Wilting
Background: Primary testing for high-risk HPV (hrHPV) is increasingly implemented in cervical cancer screening programs. Many hrHPV-positive women, however, harbor clinically irrelevant infections, demanding additional disease markers to prevent over-referral and over-treatment. Most promising biomarkers reflect molecular events relevant to the disease process that can be measured objectively in small amounts of clinical material, such as miRNAs. We previously identified eight miRNAs with altered expression in cervical precancer and cancer due to either methylation-mediated silencing or chromosomal alterations...
2018: Clinical Epigenetics
L Chuang, J Berek, T Randall, M McCormack, K Schmeler, R Manchanda, T Rebbeck, C J Jeng, D Pyle, M Quinn, E Trimble, R Naik, C H Lai, K Ochiai, L Denny, N Bhatla
Eighty-five percent of the incidents and deaths from cervical cancer occur in low and middle income countries. In many of these countries, this is the most common cancer in women. The survivals of the women with gynecologic cancers are hampered by the paucity of prevention, screening, treatment facilities and gynecologic oncology providers. Increasing efforts dedicated to improving education and research in these countries have been provided by international organizations. We describe here the existing educational and research programs that are offered by major international organizations, the barriers and opportunities provided by these collaborations and hope to improve the outcomes of cervical cancer through these efforts...
August 2018: Gynecologic Oncology Reports
Aurélie Bertaut, Julien Coudert, Leila Bengrine, Vincent Dancourt, Christine Binquet, Serge Douvier
BACKGROUND: We aimed to determine participation rates and factors associated with participation in colorectal (fecal occul blood test) and cervical cancer (Pap-smear) screening among a population of women participating in breast cancer screening. METHODS: From August to October 2015, a self-administered questionnaire was sent by post to 2 900 women aged 50-65, living in Côte-d'Or, France, and who were up to date with mammogram screening. Polytomic logistic regression was used to identify correlates of participation in both cervical and colorectal cancer screenings...
2018: PloS One
Anayawa Nyambe, Jarl K Kampen, Stridutt K Baboo, Guido Van Hal
In order to prevent the spread of cervical cancer, people must be aware and knowledgeable about the available preventive practices such as screening and vaccination. The purpose of this study was to determine the extent that film is effective in disseminating information on cervical cancer and its prevention to women and men in Lusaka. A pilot intervention study was carried out at churches in Lusaka city from August to September 2017. A sample size of 38 women and 43 men filled in both baseline and follow-up questionnaires...
June 20, 2018: Journal of Cancer Education: the Official Journal of the American Association for Cancer Education
Julio Cesar Teixeira, Carlos Afonso Maestri, Helymar da Costa Machado, Luiz Carlos Zeferino, Newton Sérgio de Carvalho
OBJECTIVE:  The aim of this study was to assess the time trends and pattern of cervical cancer diagnosed in the period from 2001 to 2012 by means of an opportunistic screening program from two developed regions in Brazil. METHODS:  An observational study analyzing 3,364 cancer records ( n  = 1,646 from Campinas and n  = 1,718 from Curitiba region) available in hospital-based cancer registries was done. An additional 1,836 records of CIN3/AIS from the region of Campinas was analyzed...
June 20, 2018: Revista Brasileira de Ginecologia e Obstetrícia
Uma Singh, Sabuhi Qureshi, Neha Negi, Nisha Singh, Madhumati Goel, Kirti Srivastava
Background & objectives: Cancer cervix is one of the most common forms of genital malignancy among Indian women. Recurrence is seen in a significant number of cases. The conventional cervical smear technique has inherent problems and screening and interpretation errors. This study was undertaken to assess the efficacy of liquid-based cytology (LBC) as a method for cytological follow up and detection of recurrence in treated cases of cancer cervix and to compare it with conventional Pap smear technique to find the best screening method for detection of recurrence in these patients...
March 2018: Indian Journal of Medical Research
Amy E Albright, Rebecca S Allen
Human papillomavirus (HPV) is currently the most common sexually transmitted disease in the United States, with potentially serious health consequences, including cervical cancer. Young adults are particularly at risk of infection, but many remain unvaccinated. Low health literacy may contribute to poor knowledge of HPV and lack of vaccine uptake, and women living in the Southeastern United States are particularly at risk for lower vaccination rates and cervical cancer screening adherence. Three-hundred-sixty undergraduates at a Southeastern U...
June 19, 2018: Journal of Community Health
Phuong Lien Tran, Caroline Benski, Manuela Viviano, Patrick Petignat, Christophe Combescure, Jeromine Jinoro, Josea Lea Herinianasolo, Pierre Vassilakos
OBJECTIVES: Colposcopes are expensive, heavy, and need specialized technical service, which may outreach the capacity of low-resource settings. Our aim was to assess the performance of smartphone-based digital images for the detection of cervical intraepithelial neoplasia grade 2 or worse (CIN2+). METHODS: Human papillomavirus (HPV)-positive women recruited through a cervical cancer screening campaign had VIA/VILI assessment (visual inspection after application of acetic acid/lugol's iodine)...
June 20, 2018: International Journal of Technology Assessment in Health Care
Celestine Mun Ting Yeo, Huang Fang, Thilagamangai, Serena Siew Lin Koh, Shefaly Shorey
AIM: To understand factors that influence women's decisions to go for Pap smears. BACKGROUND: Globally, cervical cancer is the fourth most common cancer among women. In Singapore, cervical cancer is on the rise and has been found to be the eighth highest cause of death among women. Research has shown that regular screening for cervical cancer with Pap smear reduces cervical cancer related mortality. However, Pap smear awareness is still limited and its uptake in Singapore is highly opportunistic, requiring the need for a deeper understanding of the factors that influence Pap smear uptake among women in Singapore...
June 19, 2018: Journal of Advanced Nursing
Sasha Hernandez, Esther Han, Juan Manuel Chuc Ajanel, Leah Jones, Jill Edwardson
Mental health is more prevalent among Indigenous populations than in the general population,[1] with Indigenous women at highest risk of disease burden.[2] While gender inequality and biological factors[3] contribute to this disparity between sexes, there is limited understanding of the social and clinical characteristics of Indigenous women in Latin America impacted by mental health disorders. Clearer understanding is imperative in helping to alleviate the global burden of such disorders among these vulnerable populations...
June 19, 2018: International Journal of Gynaecology and Obstetrics
Nicole G Campos, Naomi Lince-Deroche, Carla J Chibwesha, Cynthia Firnhaber, Jennifer S Smith, Pam Michelow, Gesine Meyer-Rath, Lise Jamieson, Suzette Jordaan, Monisha Sharma, Catherine Regan, Stephen Sy, Gui Liu, Vivien Tsu, Jose Jeronimo, Jane J Kim
BACKGROUND: Women with HIV face an increased risk of human papillomavirus (HPV) acquisition and persistence, cervical intraepithelial neoplasia, and invasive cervical cancer. Our objective was to determine the cost-effectiveness of different cervical cancer screening strategies among women with HIV in South Africa. METHODS: We modified a mathematical model of HPV infection and cervical disease to reflect co-infection with HIV. The model was calibrated to epidemiologic data from HIV-infected women in South Africa...
June 15, 2018: Journal of Acquired Immune Deficiency Syndromes: JAIDS
Katia Ramos Moreira Leite, Thais Silva, Bruna Naum, Flavio Canavez, Juliana Canavez, Ruan Pimenta, Sabrina Reis, Luiz Heraldo Camara-Lopes
OBJECTIVE: To test the performance of a new fixative for pap smear collection for liquid-based cervical cytology, CellPreserv® and compare it with the commercially available, PreservCyt® used in the diagnosis and detection of human papillomavirus (HPV). METHODS: Seven hundred twenty five women participated in this study after signing an informed consent. The specimens were collected using a traditional device, agitated in PBS, and equally divided in both fixatives...
June 18, 2018: Acta Cytologica
Sonia Andersson, Karen Belkić, Miriam Mints, Ellinor Östensson
OBJECTIVE: Self-sampling to test for high risk human papilloma virus (HPV) is becoming an increasingly important component of cervical cancer screening. The aim of this observational study is to examine how women treated for high-grade cervical intraepithelial neoplasia (CIN) view HPV self-sampling. METHODS: Invited to participate in the present study were patients who had undergone treatment of high-grade CIN (grade 2 or higher) and were followed-up at 6-months at the Karolinska University Hospital, Stockholm...
2018: PloS One
M Abbas, V S Kushwaha, K Srivastava, S T Raza, M Banerjee
BACKGROUND: Certain forms of chemoradiotherapy generate toxic reactive oxygen species, which may be ameliorated by antioxidant enzymes such as glutathione S-transferase (GST). Genetic polymorphisms of GST may predict treatment outcomes and can be used as genetic marker to screen patients before treatment. We hypothesised an effect of GST polymorphisms on the response and toxicities produced by chemoradiation therapy. MATERIALS AND METHODS: GST polymorphisms were determined by multiplex polymerase chain reaction (mPCR) and PCR-restriction fragment length polymorphism (PCR-RFLP) in 227 women with cervical cancer receiving cisplatin based chemoradiotherapy...
June 18, 2018: British Journal of Biomedical Science
Y T Nejo, D O Olaleye, G N Odaibo
There is a great variation in the prevalence of cervical HPV infection worldwide with some of the highest rates being found in African women. Early onset of sexual activity (≤ 15 age), multiparity and sexual promiscuity have been recognized as some of the significant risk factors for HPV infection. In Nigeria, there is scarcity of data on the degree of relationship between these factors and the prevalence of HPV infection. Thus, this study was designed to determine the prevalence of genital HPV infection with its potential risk factors among women in Southwest Nigeria...
February 2018: Archives of basic and applied medicine
Jose Candido Caldeira Xavier-Júnior, Deolino João Camilo-Júnior, Ana Paula Hehnes Guedes do Amaral Gardini, Solange Correa Garcia Pires D'ávilla, Neivio José Mattar
The Brazilian Cervical Cancer Screening Program recommends that women are screened between ages 25 and 69 years, with cervical smears every 3 years after two consecutive negative annual smears.[1] The high-risk HPV test is not available in Brazil and the screening is opportunistic, without invitation. In 10 years it is expected that every woman will receive three to four screening examinations.[1]. This article is protected by copyright. All rights reserved.
June 15, 2018: International Journal of Gynaecology and Obstetrics
José Gabriel Solís, Tomás Iván Briones-Torres
Background: Cervical cancer represents the second leading cause of malignant neoplasm mortality in women globally. Cervical cytology is the most important screening study. It is therefore of interest to know the prevalence of cytological alterations in the Mexican population. In this study the objective was to calculate the prevalence of intraepithelial lesion in cervical screening cytology. Methods: An observational, descriptive and cross-sectional study was developed; the sample was 379 patients from 21 to 64 years of age; we included patients who underwent cervical screening cytology registered in the Detección Oportuna de Cáncer Cervicouterino (DOC-CACU) program database...
March 2018: Revista Médica del Instituto Mexicano del Seguro Social
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