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Cervical cancer screening

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https://www.readbyqxmd.com/read/29667008/eco-friendly-synthesis-in-vitro-anti-proliferative-evaluation-and-3d-qsar-analysis-of-a-novel-series-of-monocationic-2-aryl-heteroaryl-substituted-6-2-imidazolinyl-benzothiazole-mesylates
#1
Livio Racané, Lucija Ptiček, Mirela Sedić, Petra Grbčić, Sandra Kraljević Pavelić, Branimir Bertoša, Irena Sović, Grace Karminski-Zamola
Herein, we describe the synthesis of twenty-one novel water-soluble monocationic 2-aryl/heteroaryl-substituted 6-(2-imidazolinyl)benzothiazole mesylates 3a-3u and present the results of their anti-proliferative assays. Efficient syntheses were achieved by three complementary simple two-step synthetic protocols based on the condensation reaction of aryl/heteroaryl carbaldehydes or carboxylic acid. We developed an eco-friendly synthetic protocol using glycerol as green solvent, particularly appropriate for the condensation of thermally and acid-sensitive heterocycles such as furan, benzofuran, pyrrole, and indole...
April 17, 2018: Molecular Diversity
https://www.readbyqxmd.com/read/29666967/health-maintenance-in-inflammatory-bowel-disease
#2
REVIEW
Fazia A Mir, Sunanda V Kane
PURPOSE OF REVIEW: Patients with inflammatory bowel disease (IBD) are not receiving preventative care services at the same rate as the general population. IBD patients are at increased risk for infections, osteoporosis, and certain malignancies secondary to their disease and as they are on immunosuppressive therapy. They are a younger population and often times consider their gastroenterologist as their primary care physician. In this review, we discuss up-to-date evidence pertaining to vaccine-preventable illnesses in the immunosuppressed IBD patient, screening for bone health, cervical cancer, skin malignancies, psychological wellbeing, and smoking cessation...
April 17, 2018: Current Gastroenterology Reports
https://www.readbyqxmd.com/read/29664054/limited-role-of-promoter-methylation-of-mgmt-and-c13orf18-in-triage-of-low-grade-squamous-intraepithelial-lesion
#3
Lu-Lu Sun, Yuan Liu, Xiao Sun, Lei Pan, Dan Wu, Yu-Dong Wang
Background: Promoter methylation of MGMT and C13ORF18 has been confirmed as a potential biomarker for early diagnosis of cervical cancer. The aim of this study was to evaluate the performance of MGMT and C13ORF18 promoter methylation for triage of cytology screening samples and explore the potential mechanism. Methods: Methylation-sensitive high-resolution melting was used to detect promoter methylation of MGMT and C13ORF18 in 124 cervical samples. High-risk human papillomavirus (HR-HPV) was detected by the Digene Hybrid Capture 2® ...
April 20, 2018: Chinese Medical Journal
https://www.readbyqxmd.com/read/29663734/new-biological-research-and-understanding-of-papanicolaou-s-test
#4
REVIEW
Elizabeth R Smith, Sophia H George, Erin Kobetz, Xiang-Xi Xu
The development of the Papanicolaou smear test by Dr. George Nicholas Papanicolaou (1883-1962) is one of the most significant achievements in screening for disease and cancer prevention in history. The Papanicolaou smear has been used for screening of cervical cancer since the 1950s. The test is technically straightforward and practical and based on a simple scientific observation: malignant cells have an aberrant nuclear morphology that can be distinguished from benign cells. Here, we review the scientific understanding that has been achieved and continues to be made on the causes and consequences of abnormal nuclear morphology, the basis of Dr...
April 16, 2018: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/29663363/cervical-cancer-risk-in-hpv-positive-women-after-a-negative-fam19a4-mir124-2-methylation-test-a-post-hoc-analysis-in-the-pobascam-trial-with-14-year-follow-up
#5
Lise M A De Strooper, Johannes Berkhof, Renske D M Steenbergen, Birgit I Lissenberg-Witte, Peter J F Snijders, Chris J L M Meijer, Daniëlle A M Heideman
DNA methylation analysis of cervical scrapes using FAM19A4 and mir124-2 genes has shown a good clinical performance in detecting cervical cancer and advanced CIN lesions in need of treatment in HPV-positive women. To date, longitudinal data on the cancer risk of methylation test-negative women are lacking. In this study, we assessed the longitudinal outcome of FAM19A4/mir124-2 methylation analysis in an HPV-positive screening cohort with 14 years of follow-up. Archived HPV-positive cervical scrapes of 1040 women (age 29-61 years), who were enrolled in the POBASCAM screening trial (ISRCTN20781131) were tested for FAM19A4/mir124-2 methylation...
April 16, 2018: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/29660849/comparison-of-hpv-genotyping-and-cytology-triage-compact-study-design-methods-and-baseline-results-in-14-642-women
#6
Satomi Aoyama-Kikawa, Hiromasa Fujita, Sharon J B Hanley, Mitsunori Kasamo, Kokichi Kikuchi, Toshihiko Torigoe, Yoshihiro Matsuno, Akiko Tamakoshi, Takayuki Sasaki, Motoki Matsuura, Yasuhito Kato, Peixin Dong, Hidemichi Watari, Tsuyoshi Saito, Kazuo Sengoku, Noriaki Sakuragi
While cytology-based screening programs have significantly reduced mortality and morbidity from cervical cancer, the global consensus is that primary human papillomavirus (HPV) testing for cervical screening increases detection of high-grade cervical intraepithelial neoplasia (CIN) and invasive cancer. However, the optimal triage strategy for HPV-positive women to avoid over-referral to colposcopy may be setting specific. Since Japan requires data that has been generated domestically to modify screening guidelines, we conducted a 3-year prospective study COMparison of HPV genotyping And Cytology Triage (COMPACT) to evaluate the potential role of HPV16/18 partial genotyping and cytology for primary HPV screening, Totally, 14,642 women aged 20-69yrs undergoing routine screening at three centers in Hokkaido were enrolled...
April 16, 2018: Cancer Science
https://www.readbyqxmd.com/read/29659930/automated-cervical-screening-and-triage-based-on-hpv-testing-and-computer-interpreted-cytology
#7
Kai Yu, Noorie Hyun, Barbara Fetterman, Thomas Lorey, Tina R Raine-Bennett, Han Zhang, Robin E Stamps, Nancy E Poitras, William Wheeler, Brian Befano, Julia C Gage, Philip E Castle, Nicolas Wentzensen, Mark Schiffman
Background: State-of-the-art cervical cancer prevention includes human papillomavirus (HPV) vaccination among adolescents and screening/treatment of cervical precancer (CIN3/AIS and, less strictly, CIN2) among adults. HPV testing provides sensitive detection of precancer but, to reduce overtreatment, secondary "triage" is needed to predict women at highest risk. Those with the highest-risk HPV types or abnormal cytology are commonly referred to colposcopy; however, expert cytology services are critically lacking in many regions...
April 11, 2018: Journal of the National Cancer Institute
https://www.readbyqxmd.com/read/29655523/the-clinical-value-of-hpv-e6-e7-and-stat3-mrna-detection-in-cervical-cancer-screening
#8
Yibing Fan, Zongji Shen
OBJECTIVE: To explore the value of human papillomavirus (HPV) E6/E7 and signal transducer and activator of transcription 3 (STAT3) mRNA detection in the screening of cervical lesions. METHODS: 192 patients with abnormal ThinPrep cytology test (TCT) results and/or high-risk HPV infection were screened to identify possible cervical lesions in cases. Diagnoses were confirmed by histopathology. Fluorescence in situ hybridization (FISH) was performed to detect and qualify the mRNAs of HPV E6/E7, STAT3, and Survivin in cervical exfoliated cells...
February 11, 2018: Pathology, Research and Practice
https://www.readbyqxmd.com/read/29651669/hpv-screening-and-vaccination-strategies-in-an-unscreened-population-a-mathematical-modeling-study
#9
Rachael M Milwid, Federico Frascoli, Marc Steben, Jane M Heffernan
Human papillomavirus (HPV), a sexually transmitted infection, is the necessary cause of cervical cancer, the third most common cancer affecting women worldwide. Prevention and control strategies include vaccination, screening, and treatment. While HPV prevention and control efforts are important worldwide, they are especially important in low-income areas with a high infection rate or high rate of cervical cancer. This study uses mathematical modeling to explore various vaccination and treatment strategies to control for HPV and cervical cancer while using Nepal as a case study...
April 12, 2018: Bulletin of Mathematical Biology
https://www.readbyqxmd.com/read/29650746/comprehensive-preventive-care-assessments-for-adults-with-intellectual-and-developmental-disabilities-part-1-how-do-we-know-if-it-is-happening
#10
Glenys Smith, Hélène Ouellette-Kuntz, Michael Green
OBJECTIVE: To determine how best to measure the provision of comprehensive preventive care assessment of adults with intellectual and developmental disabilities (IDD). DESIGN: Cross-sectional study. SETTING: Ontario. PARTICIPANTS: Adults with IDD between 40 and 64 years of age in 2013 and 2014. MAIN OUTCOME MEASURES: Health examination was defined using the Ontario Health Insurance Plan billing data fee code A003 (with diagnostic code 917 or 319) or fee code K131, and the Primary Care Quality Composite Score (PCQS), a measure combining 7 different screening maneuvers (lipid, glucose, breast cancer, cervical cancer, colorectal cancer, eye, and hemoglobin A1c screening), was identified using administrative health data...
April 2018: Canadian Family Physician Médecin de Famille Canadien
https://www.readbyqxmd.com/read/29649025/risk-of-anal-cancer-in-women-with-a-human-papillomavirus-related-gynecological-neoplasm-puerto-rico-1987-2013
#11
Adrianna I Acevedo-Fontánez, Erick Suárez, Carlos R Torres Cintrón, Ana P Ortiz
OBJECTIVE: The aim of the study was to estimate the magnitude of the association between HPV-related gynecological neoplasms and secondary anal cancer among women in Puerto Rico (PR). MATERIALS AND METHODS: We identified 9,489 women who had been diagnosed with a primary cervical, vaginal, or vulvar tumor during 1987-2013. To describe the trends of invasive cervical, vulvar, vaginal, and anal cancer, the age-adjusted incidence rates were estimated using the direct method (2000 US as Standard Population)...
April 11, 2018: Journal of Lower Genital Tract Disease
https://www.readbyqxmd.com/read/29643651/pilot-study-of-an-open-source-image-analysis-software-for-automated-screening-of-conventional-cervical-smears
#12
Parikshit Sanyal, Prosenjit Ganguli, Sanghita Barui, Prabal Deb
Introduction: The Pap stained cervical smear is a screening tool for cervical cancer. Commercial systems are used for automated screening of liquid based cervical smears. However, there is no image analysis software used for conventional cervical smears. The aim of this study was to develop and test the diagnostic accuracy of a software for analysis of conventional smears. Materials and Methods: The software was developed using Python programming language and open source libraries...
April 2018: Journal of Cytology
https://www.readbyqxmd.com/read/29630095/pathogenicity-of-high-risk-hpv-infection-in-pseudocondyloma-of-vulvae-and-its-carcinogenicity-in-inducing-cervical-lesions
#13
P-F Song, J-Y Chen, Q He, J Wang, J Xu
OBJECTIVE: To identify high-risk human papillomavirus (HPV) infection in pseudocondyloma of vulvae (PV) and the causal relationship between high-risk HPV infection and cervical cancer. PATIENTS AND METHODS: The patients were divided into condyloma acuminatum group, PV groups and PV high-risk HPV infection group according to the clinical data and morphological features. Condyloma acuminatum group and PV group were two control groups. The exfoliated cells were detected and typed by human HPV nucleic acid typing kit...
March 2018: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29630008/ovarian-cancer-prevention-and-screening
#14
Usha Menon, Chloe Karpinskyj, Aleksandra Gentry-Maharaj
There has been much progress in ovarian cancer screening and prevention in recent years. Improved tools that combine genetic and epidemiologic factors to predict an individual's ovarian cancer risk are set to become available for tailoring preventive and screening approaches. The increasing evidence on tubal origins of a proportion of ovarian cancer has paved the way to use of opportunistic bilateral salpingectomy at tubal ligation and hysterectomy in the general population. Clinical trials are in progress to estimate the long-term effects on endocrine function...
April 6, 2018: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29629685/evaluating-the-effect-of-ward-based-outreach-teams-on-primary-healthcare-performance-in-north-west-province-south-africa-a-plausibility-design-using-routine-data
#15
T Assegaai, G Reagon, H Schneider
BACKGROUND: North West Province (NWP), South Africa, was an early adopter of the primary healthcare (PHC) ward-based outreach team (WBOT) strategy and has made considerable progress in implementing it. Given the interest in and expectations of greater investment in WBOTs, assessing their impact on and contribution to PHC outputs and health outcomes is becoming increasingly important. OBJECTIVES: To describe the application of a plausibility evaluation design for assessing the contribution of WBOTs to PHC performance in NWP, comparing changes in coverage, utilisation and outcome indicators in facilities with and without WBOTs...
March 28, 2018: South African Medical Journal, Suid-Afrikaanse Tydskrif Vir Geneeskunde
https://www.readbyqxmd.com/read/29629509/awareness-of-hpv-and-cervical-cancer-prevention-among-university-health-sciences-students-in-cyprus
#16
Paraskevi A Farazi, Mohammad Siahpush, Tzeyu L Michaud, Jungyoon Kim, Chenai Muchena
Cervical cancer is preventable; however, despite the existence of primary and secondary means of prevention, its incidence is still higher in certain socioeconomic groups and countries, suggesting gaps in cervical cancer prevention. The objective of this study was to evaluate the knowledge and awareness of health sciences university students in Cyprus regarding HPV and cervical cancer in order to better guide the future development of educational programs to improve cervical cancer prevention. This was a cross-sectional study of 178 university health sciences students in Cyprus using a validated questionnaire on HPV and cervical cancer prevention...
April 9, 2018: Journal of Cancer Education: the Official Journal of the American Association for Cancer Education
https://www.readbyqxmd.com/read/29627221/fluorescence-microscopy-of-h-e-stained-cervical-biopsies-to-assist-the-diagnosis-and-grading-of-cin
#17
REVIEW
Mario R Castellanos, Vijeyaluxmy Motilal Nehru, Edyta C Pirog, Lynne Optiz
BACKGROUND: Prevention of cervical cancer is based upon the accurate diagnosis and grading of cervical lesions identified during screening. The pathological classification of cervical intraepithelial neoplasia (CIN) is problematic, as it relies on subjective criteria and is known to have high interobserver variability and low reproducibility. These limitations can result in either over or under treatment of patients. Biomarkers to improve CIN diagnosis have not overcome all these challenges...
March 26, 2018: Pathology, Research and Practice
https://www.readbyqxmd.com/read/29626643/patterns-of-repeated-anal-cytology-results-among-hiv-positive-and-hiv-negative-men-who-have-sex-with-men
#18
Hilary A Robbins, Dorothy J Wiley, Ken Ho, Michael Plankey, Susheel Reddy, Nancy Joste, Teresa M Darragh, Elizabeth C Breen, Stephen Young, Gypsyamber D'Souza
BACKGROUND: Men who have sex with men (MSM) are at increased risk for anal cancer. In cervical cancer screening, patterns of repeated cytology results are used to identify low- and high-risk women, but little is known about these patterns for anal cytology among MSM. METHODS: We analyzed Multicenter AIDS Cohort Study (MACS) data for MSM who were offered anal cytology testing annually (HIV-positive) or every 2 years (HIV-negative) for 4 years. RESULTS: Following an initial negative (normal) cytology, the frequency of a second negative cytology was lower among HIV-positive MSM with CD4≥500 (74%) or CD4<500 (68%) than HIV-negative MSM (83%) (p<0...
April 4, 2018: Papillomavirus Research
https://www.readbyqxmd.com/read/29624947/the-need-for-societal-investment-to-improve-cervical-cancer-outcomes-in-nigeria-a-commentary
#19
Jonah Musa
Although cervical cancer is a preventable cancer with a well-known natural history, it remains a huge burden in developing countries of sub-Saharan Africa where organized cervical cancer screening services are lacking. Developed countries that have invested on providing organized screening programs have made substantial progress in reducing both incidence and mortality due to cervical cancer. Implementing evidence-based interventions such as human papillomavirus (HPV) vaccination of young girls, early detection and treatment of premalignant conditions of the cervix through conventional Pap cytology, HPV screening or visual aided inspection with acetic acid could significantly reduce incidence of new cases at population level...
December 2017: African Journal of Reproductive Health
https://www.readbyqxmd.com/read/29620291/integrated-analysis-of-long-non%C3%A2-coding-rna-competing-interactions-revealed-potential-biomarkers-in-cervical-cancer-based-on-a-public-database
#20
Wen-Juan Wu, Yang Shen, Jing Sui, Cheng-Yun Li, Sheng Yang, Si-Yi Xu, Man Zhang, Li-Hong Yin, Yue-Pu Pu, Ge-Yu Liang
Cervical cancer (CC) is a common gynecological malignancy in women worldwide. Using an RNA sequencing profile from The Cancer Genome Atlas (TCGA) and the CC patient information, the aim of the present study was to identify potential long non‑coding RNA (lncRNA) biomarkers of CC using bioinformatics analysis and building a competing endogenous RNA (ceRNA) co‑expression network. Results indicated several CC‑specific lncRNAs, which were associated with CC clinical information and selected some of them for validation and evaluated their diagnostic values...
April 5, 2018: Molecular Medicine Reports
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