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Stewart acid-base

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https://www.readbyqxmd.com/read/27861448/an-app-to-calculate-bedside-stewart-acid-base-equations
#1
John H P Friesen
No abstract text is available yet for this article.
December 2016: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/27760042/use-of-elements-of-the-stewart-model-strong-ion-approach-sid3-sid4-atot-a-side-and-sig-for-the-diagnostics-of-respiratory-acidosis-in-brachycephalic-dogs
#2
P Sławuta, G Sapikowski, B Sobieraj
: Buffer systems of blood and tissues, which have the ability to bind with and give up hydrogen ions, participate in maintaining the acid-base balance (ABB) of the organism. According to the classic model, the system of carbonic acid and bicarbonates, where the first component serves the role of an acid and the second a base, determines plasma pH. The so-called Stewart model, which assumes that ions in blood serum can be separated into completely dissociated - nonbuffer and not dissociated - buffer ions which may give up or accept H+ions, also describes the ABB of the organism...
September 1, 2016: Polish Journal of Veterinary Sciences
https://www.readbyqxmd.com/read/27753644/tryptophan-and-cysteine-mutations-in-m1-helices-of-%C3%AE-1%C3%AE-3%C3%AE-2l-%C3%AE-aminobutyric-acid-type-a-receptors-indicate-distinct-intersubunit-sites-for-four-intravenous-anesthetics-and-one-orphan-site
#3
Anahita Nourmahnad, Alex T Stern, Mayo Hotta, Deirdre S Stewart, Alexis M Ziemba, Andrea Szabo, Stuart A Forman
BACKGROUND: γ-Aminobutyric acid type A (GABAA) receptors mediate important effects of intravenous general anesthetics. Photolabel derivatives of etomidate, propofol, barbiturates, and a neurosteroid get incorporated in GABAA receptor transmembrane helices M1 and M3 adjacent to intersubunit pockets. However, photolabels have not been consistently targeted at heteromeric αβγ receptors and do not form adducts with all contact residues. Complementary approaches may further define anesthetic sites in typical GABAA receptors...
December 2016: Anesthesiology
https://www.readbyqxmd.com/read/27638212/palaeoproteomic-evidence-identifies-archaic-hominins-associated-with-the-ch%C3%A3-telperronian-at-the-grotte-du-renne
#4
Frido Welker, Mateja Hajdinjak, Sahra Talamo, Klervia Jaouen, Michael Dannemann, Francine David, Michèle Julien, Matthias Meyer, Janet Kelso, Ian Barnes, Selina Brace, Pepijn Kamminga, Roman Fischer, Benedikt M Kessler, John R Stewart, Svante Pääbo, Matthew J Collins, Jean-Jacques Hublin
In Western Europe, the Middle to Upper Paleolithic transition is associated with the disappearance of Neandertals and the spread of anatomically modern humans (AMHs). Current chronological, behavioral, and biological models of this transitional period hinge on the Châtelperronian technocomplex. At the site of the Grotte du Renne, Arcy-sur-Cure, morphological Neandertal specimens are not directly dated but are contextually associated with the Châtelperronian, which contains bone points and beads. The association between Neandertals and this "transitional" assemblage has been controversial because of the lack either of a direct hominin radiocarbon date or of molecular confirmation of the Neandertal affiliation...
October 4, 2016: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/27636585/stewart-versus-traditional-approach-to-acid-base-disorders
#5
Michael Emmett
No abstract text is available yet for this article.
October 2016: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/27621395/pancreox-a-randomized-phase-iii-study-of-5-fluorouracil-leucovorin-with-or-without-oxaliplatin-for-second-line-advanced-pancreatic-cancer-in-patients-who-have-received-gemcitabine-based-chemotherapy
#6
Sharlene Gill, Yoo-Joung Ko, Christine Cripps, Annie Beaudoin, Sukhbinder Dhesy-Thind, Muhammad Zulfiqar, Pawel Zalewski, Thuan Do, Pablo Cano, Wendy Yin Han Lam, Scot Dowden, Helene Grassin, John Stewart, Malcolm Moore
PURPOSE: The standard of care for second-line therapy in patients with advanced pancreatic cancer after gemcitabine-based therapy is not clearly defined. The CONKO-003 phase III study reported a survival benefit with second-line fluorouracil (FU) and oxaliplatin using the oxaliplatin, folinic acid, and FU (OFF) regimen.(1) PANCREOX was a phase III multicenter trial to evaluate the benefit of FU and oxaliplatin administered as modified FOLFOX6 (mFOLFOX6; infusional fluorouracil, leucovorin, and oxaliplatin) versus infusional FU/leucovorin (LV) in this setting...
September 12, 2016: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/27611634/non-targeted-metabolite-profiling-highlights-the-potential-of-strawberry-leaves-as-a-resource-for-specific-bioactive-compounds
#7
Anna Kårlund, Kati Hanhineva, Marko Lehtonen, Gordon J McDougall, Derek Stewart, Reijo O Karjalainen
BACKGROUND: The non-edible parts of horticultural crops, such as leaves, contain substantial amounts of valuable bioactive compounds which are currently only little exploited. For example strawberry (Fragaria × ananassa) leaves may be a promising bioresource for diverse health-related applications. However, product standardization sets a real challenge, especially when the leaf material comes from varying cultivars. The first step towards better quality control of berry fruit leaf-based ingredients and supplements is to understand metabolites present and their stability in different plant cultivars, so we surveyed the distribution of potentially bioactive strawberry leaf metabolites in six different strawberry cultivars...
September 9, 2016: Journal of the Science of Food and Agriculture
https://www.readbyqxmd.com/read/27569705/metabolomic-determination-of-pathogenesis-of-late-onset-preeclampsia
#8
Ray O Bahado-Singh, Argyro Syngelaki, Rupsari Mandal, Stewart F Graham, Ranjit Akolekar, Beomsoo Han, Trent C Bjondahl, Edison Dong, Samuel Bauer, Zeynep Alpay-Savasan, Onur Turkoglu, Dotun Ogunyemi, Liona C Poon, David S Wishart, Kypros H Nicolaides
OBJECTIVE: Our primary objective was to apply metabolomic pathway analysis of first trimester maternal serum to provide an insight into the pathogenesis of late-onset preeclampsia (late-PE) and thereby identify plausible therapeutic targets for PE. METHODS: NMR-based metabolomics analysis was performed on 29 cases of late-PE and 55 unaffected controls. In order to achieve sufficient statistical power to perform the pathway analysis, these cases were combined with a group of previously analyzed specimens, 30 late-PE cases and 60 unaffected controls...
August 28, 2016: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/27562561/chloride-content-of-solutions-used-for-regional-citrate-anticoagulation-might-be-responsible-for-blunting-correction-of-metabolic-acidosis-during-continuous-veno-venous-hemofiltration
#9
Rita Jacobs, Patrick M Honore, Marc Diltoer, Herbert D Spapen
BACKGROUND: Citrate, the currently preferred anticoagulant for continuous veno-venous hemofiltration (CVVH), may influence acid-base equilibrium. METHODS: The effect of 2 different citrate solutions on acid-base status was assessed according to the Stewart-Figge approach in two consecutive cohorts of critically ill adult patients. The first group received Prismocitrate 10/2 (PC10/2; 10 mmol citrate/L). The next group was treated with Prismocitrate 18/0 (PC18; 18 mmol citrate/L)...
2016: BMC Nephrology
https://www.readbyqxmd.com/read/27546763/the-prognostic-value-of-the-strong-ion-gap-in-acute-pancreatitis
#10
Xiao Shen, Lu Ke, Dongliang Yang, Jing Sun, Zhihui Tong, Baiqiang Li, Gang Li, Weiqin Li, Jieshou Li, Rinaldo Bellomo
PURPOSE: In this study, we aimed to evaluate the predictive value of Stewart-derived parameters for the development of severe type of acute pancreatitis (AP) and for AP-related mortality. METHODS: We studied 186 patients admitted to the hospital with AP. We performed blood gas and biochemical analysis for each patient on admission. We calculated multiple metrics according to the Stewart's acid-base theory and assessed their accuracy as predictors of AP severity and mortality...
July 9, 2016: Journal of Critical Care
https://www.readbyqxmd.com/read/27465935/effect-of-laparoscopic-sleeve-gastrectomy-on-fasting-gastrointestinal-pancreatic-and-adipose-derived-hormones-and-on-non-esterified-fatty-acids
#11
John E Farey, Tamara C Preda, Oliver M Fisher, Angelique J Levert-Mignon, Rebecca L Stewart, Elisabeth Karsten, Benjamin R Herbert, Michael M Swarbrick, Reginald V Lord
BACKGROUND: Alterations in gastrointestinal, pancreatic, and adipose hormone levels may have a greater role in weight loss than initially appreciated. The laparoscopic sleeve gastrectomy (LSG) operation is now the most frequently performed bariatric operation in many countries, but there are relatively few data regarding its molecular effects. We sought to characterize the effect of LSG on fasting plasma levels of selected hormones and on non-esterified fatty acids (NEFA), and to compare these to levels in non-obese control individuals...
July 27, 2016: Obesity Surgery
https://www.readbyqxmd.com/read/27447733/metabolomics-analysis-of-hormone-responsive-and-triple-negative-breast-cancer-cell-responses-to-paclitaxel-identify-key-metabolic-differences
#12
Delisha A Stewart, Jason H Winnike, Susan L McRitchie, Robert F Clark, Wimal W Pathmasiri, Susan J Sumner
To date, no targeted therapies are available to treat triple negative breast cancer (TNBC), while other breast cancer subtypes are responsive to current therapeutic treatment. Metabolomics was conducted to reveal differences in two hormone receptor-negative TNBC cell lines and two hormone receptor-positive Luminal A cell lines. Studies were conducted in the presence and absence of paclitaxel (Taxol). TNBC cell lines had higher levels of amino acids, branched-chain amino acids, nucleotides, and nucleotide sugars and lower levels of proliferation-related metabolites like choline compared with Luminal A cell lines...
September 2, 2016: Journal of Proteome Research
https://www.readbyqxmd.com/read/27410514/old-and-new-approaches-to-the-interpretation-of-acid-base-metabolism-starting-from-historical-data-applied-to-diabetic-acidosis
#13
Roberto Mioni, Alessandra Marega, Marco Lo Cicero, Domenico Montanaro
The approach to acid-base chemistry in medicine includes several methods. Currently, the two most popular procedures are derived from Stewart's studies and from the bicarbonate/BE-based classical formulation. Another method, unfortunately little known, follows the Kildeberg theory applied to acid-base titration. By using the data produced by Dana Atchley in 1933, regarding electrolytes and blood gas analysis applied to diabetes, we compared the three aforementioned methods, in order to highlight their strengths and their weaknesses...
July 13, 2016: Scandinavian Journal of Clinical and Laboratory Investigation
https://www.readbyqxmd.com/read/27319095/-kidney-fluid-and-acid-base-balance
#14
REVIEW
Naohiro Shioji, Masao Hayashi, Hiroshi Morimatsu
Kidneys play an important role to maintain human homeostasis. They contribute to maintain body fluid, electrolytes, and acid-base balance. Especially in fluid control, we, physicians can intervene body fluid balance using fluid resuscitation and diuretics. In recent years, one type of fluid resuscitation, hydroxyl ethyl starch has been extensively studied in the field of intensive care. Although their effects on fluid resuscitation are reasonable, serious complications such as kidney injury requiring renal replacement therapy occur frequently...
May 2016: Masui. the Japanese Journal of Anesthesiology
https://www.readbyqxmd.com/read/27291295/perinatal-midline-astrocyte-development-is-impaired-in-fibroblast-growth-factor-8-hypomorphic-mice
#15
Courtney E Stewart, Kristina M Corella, Brittany D Samberg, Paula T Jones, Megan L Linscott, Wilson C J Chung
Our previous studies showed that Fgf8 mutations can cause Kallmann syndrome (KS), a form of congenital hypogonadotropic hypogonadism, in which patients do not undergo puberty and are infertile. Interestingly, some KS patients also have agenesis of the corpus callosum (ACC) suggesting that KS pathology is not limited to reproductive function. Here, we asked whether FGF8 dysfunction is the underlying cause of ACC in some KS patients. Indeed, early studies in transgenic mice with Fgf8 mutations reported the presence of failed or incomplete corpus callosum formation...
September 1, 2016: Brain Research
https://www.readbyqxmd.com/read/27206058/3-4-dihydroxyphenylalanine-peptides-as-nonperturbative-quantum-dot-sensors-of-aminopeptidase
#16
Valle Palomo, Sebastián A Díaz, Michael H Stewart, Kimihiro Susumu, Igor L Medintz, Philip E Dawson
Fluorescence-based assays for hydrolases that cleave within the substrate (endopeptidases) are common, while developing substrates for proteases that selectively cleave from peptide termini (exopeptidases) is more challenging, since the termini are specifically recognized by the enzyme and cannot be modified to facilitate a Förster resonance energy transfer (FRET)-based approach. The development of a robust system that enables the quenching of fluorescent particles by simple amino acid side chains would find broad utility for peptide sensors and would be advantageous for exopeptidases...
June 28, 2016: ACS Nano
https://www.readbyqxmd.com/read/27190719/genome-scale-investigation-of-phenotypically-distinct-but-nearly-clonal-trichoderma-strains
#17
Claudia Lange, Richard J Weld, Murray P Cox, Rosie E Bradshaw, Kirstin L McLean, Alison Stewart, Johanna M Steyaert
Biological control agents (BCA) are beneficial organisms that are applied to protect plants from pests. Many fungi of the genus Trichoderma are successful BCAs but the underlying mechanisms are not yet fully understood. Trichoderma cf. atroviride strain LU132 is a remarkably effective BCA compared to T. cf. atroviride strain LU140 but these strains were found to be highly similar at the DNA sequence level. This unusual combination of phenotypic variability and high DNA sequence similarity between separately isolated strains prompted us to undertake a genome comparison study in order to identify DNA polymorphisms...
2016: PeerJ
https://www.readbyqxmd.com/read/27140683/stewart-acid-base-a-simplified-bedside-approach
#18
David A Story
No abstract text is available yet for this article.
August 2016: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/27124905/identification-of-factors-affecting-the-success-of-next-generation-sequencing-testing-in-solid-tumors
#19
Rashmi S Goswami, Rajyalakshmi Luthra, Rajesh R Singh, Keyur P Patel, Mark J Routbort, Kenneth D Aldape, Hui Yao, Hyvan D Dang, Bedia A Barkoh, Jawad Manekia, L Jeffrey Medeiros, Sinchita Roy-Chowdhuri, John Stewart, Russell R Broaddus, Hui Chen
OBJECTIVES: Clinical laboratories are rapidly implementing next-generation sequencing (NGS) tests for mutation analysis, but there are few guidelines regarding sample quality for successful results. METHODS: We aimed to establish tissue quality parameters for successful NGS in solid tumors and to improve NGS performance. RESULTS: Analysis of 614 clinical cases tested in 2013 using a 50-gene hotspot mutation panel identified the major cause for unsuccessful NGS analysis was DNA less than 10 ng (91%, 67/74) associated with extremely small and low cellularity samples...
February 2016: American Journal of Clinical Pathology
https://www.readbyqxmd.com/read/27077882/the-essentiality-of-arachidonic-acid-in-infant-development
#20
REVIEW
Kevin B Hadley, Alan S Ryan, Stewart Forsyth, Sheila Gautier, Norman Salem
Arachidonic acid (ARA, 20:4n-6) is an n-6 polyunsaturated 20-carbon fatty acid formed by the biosynthesis from linoleic acid (LA, 18:2n-6). This review considers the essential role that ARA plays in infant development. ARA is always present in human milk at a relatively fixed level and is accumulated in tissues throughout the body where it serves several important functions. Without the provision of preformed ARA in human milk or infant formula the growing infant cannot maintain ARA levels from synthetic pathways alone that are sufficient to meet metabolic demand...
2016: Nutrients
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