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D L P Holyoake, D R Warren, C Hurt, M Aznar, M Partridge, S Mukherjee, M A Hawkins
AIMS: Gastrointestinal toxicity impedes dose escalation in chemoradiotherapy for hepatobiliary malignancies. Toxicity risk depends on clinical and radiotherapy metrics. We aimed to identify predictive factors using data from two prospective phase II clinical trials of locally advanced pancreatic cancer (LAPC). MATERIALS AND METHODS: Ninety-one patients with available data from the ARCII (59.4 Gy in 33 fractions with gemcitabine, cisplatin and nelfinavir, n = 23) and SCALOP (50...
March 27, 2018: Clinical Oncology: a Journal of the Royal College of Radiologists
Ana Isabel Vitas, Dixita Naik, Lara Pérez-Etayo, David González
The aim of this study was to determine the occurrence and patterns of resistance of extended-spectrum β-lactamase (ESBL) producing Enterobacteriaceae in food products purchased in Navarra, northern Spain. A total of 174 samples of fish and chicken were analyzed from September 2015 to September 2016, including raw and ready-to-eat products: trout (n = 25), salmon (n = 28), panga (n = 13), chicken nuggets and chicken scalopes (n = 32), sushi (n = 31) and sliced cooked poultry (n = 45)...
March 23, 2018: International Journal of Food Microbiology
C N Hurt, S Falk, T Crosby, A McDonald, R Ray, G Joseph, J Staffurth, R A Abrams, G Griffiths, T Maughan, S Mukherjee
BACKGROUND: SCALOP, a randomised, phase II trial, tested the activity and safety of gemcitabine (GEM)-based and capecitabine (CAP)-based chemoradiation (CRT) for locally advanced pancreatic cancer (LAPC). Here we present the long-term outcomes. METHODS: Eligibility: histologically proven LAPC ⩽7 cm. Following 12 weeks of induction GEMCAP chemotherapy (three cycles: GEM 1000 mg m-2 days 1, 8, 15; CAP 830 mg m-2 days 1-21 q28 days) patients with stable/responding disease, tumour ⩽6 cm, and WHO Performance Status 0-1 were randomised to receive one cycle GEMCAP followed by CAP (830 mg m-2 b...
May 9, 2017: British Journal of Cancer
Emmanouil Fokas, Emiliano Spezi, Neel Patel, Chris Hurt, Lisette Nixon, Kwun-Ye Chu, John Staffurth, Ross Abrams, Somnath Mukherjee
BACKGROUND AND PURPOSE: We performed a retrospective central review of tumour outlines in patients undergoing radiotherapy in the SCALOP trial. MATERIALS AND METHODS: The planning CT scans were reviewed retrospectively by a central review team, and the accuracy of investigators' GTV (iGTV) and PTV (iPTV) was compared to the trials team-defined gold standard (gsGTV and gsPTV) using the Jaccard Conformity Index (JCI) and Geographical Miss Index (GMI). The prognostic value of JCI and GMI was also assessed...
August 2016: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
Christopher N Hurt, Somnath Mukherjee, John Bridgewater, Stephen Falk, Tom Crosby, Alec McDonald, George Joseph, John Staffurth, Ross A Abrams, Jane M Blazeby, Sarah Bridges, Peter Dutton, Gareth Griffiths, Tim Maughan, Colin Johnson
PURPOSE: Chemoradiation therapy (CRT) for patients with locally advanced pancreatic cancer (LAPC) provides survival benefits but may result in considerable toxicity. Health-related quality of life (HRQL) measurements during CRT have not been widely reported. This paper reports HRQL data from the Selective Chemoradiation in Advanced Localised Pancreatic Cancer (SCALOP) trial, including validation of the QLQ-PAN26 tool in CRT. METHODS AND MATERIALS: Patients with locally advanced, inoperable, nonmetastatic carcinoma of the pancreas were eligible...
November 15, 2015: International Journal of Radiation Oncology, Biology, Physics
Emmanouil Fokas, Charlotte Clifford, Emiliano Spezi, George Joseph, Jennifer Branagan, Chris Hurt, Lisette Nixon, Ross Abrams, John Staffurth, Somnath Mukherjee
BACKGROUND AND PURPOSE: To evaluate the variation in investigator-delineated volumes and assess plans from the radiotherapy trial quality assurance (RTTQA) program of SCALOP, a phase II trial in locally advanced pancreatic cancer. MATERIALS AND METHODS: Participating investigators (n=25) outlined a pre-trial benchmark case as per RT protocol, and the accuracy of investigators' GTV (iGTV) and PTV (iPTV) was evaluated, against the trials team-defined gold standard GTV (gsGTV) and PTV (gsPTV), using both qualitative and geometric analyses...
December 2015: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
Stefano Cascinu
The results of the SCALOP trial were reviewed and interpreted at the light of previous trials and of the more recent LAP-07 trial. In this latter trial the role of radiotherapy after an induction chmeotherapy has been questioned. Based on these findings data from the SCALOP trial loose most of their value. In fact, while it showed that capecitabine may be combined with radiotherapy more safely than gemcitabine and it could be a standard regimen as a consolidation regimen after an induction chemotherapy, the LAP-07 trial showed that radiotherapy in combination with chemotherapy does not add any valuable effect to chemotherapy alone...
September 2013: Chinese Clinical Oncology
Silvia E Pavan, Sharon A Jansa, Robert S Voss
Short-tailed opossums (genus Monodelphis) represent one of the most speciose clades of New World marsupials, with 26 currently recognized species that collectively range from eastern Panama to northern Argentina. Here we present the first phylogenetic analyses of the genus based on dense taxonomic sampling and multiple genes. From most sampled species we obtained >4800bp of DNA sequence from one mitochondrial gene (CYTB), two autosomal exons (IRBP exon 1, BRCA1 exon 11), one autosomal intron (SLC38 intron 7), and one X-linked intron (OGT intron 14)...
October 2014: Molecular Phylogenetics and Evolution
Camilla Bruno Di-Nizo, Carolina Lima Neves, Júlio Fernando Vilela, Maria José de J Silva
Atlantic Forest, in the eastern coast of Brazil, is a hotspot of biodiversity of mammals, and Parque Estadual da Serra do Mar (PESM) is the largest continuous area of this biome. Here, we characterized the karyotype composition of the small mammals from Santa Virgínia, a region in the northern part of PESM. Specimens were collected from July 2008 to September 2009. We identified 17 species (13 rodents and 4 marsupials) from which 7 exhibited species-specific karyotypes, illustrating the importance of karyotype information in cytotaxonomy...
2014: Comparative Cytogenetics
S B Harrabi, M W Büchler, J Werner, S E Combs
No abstract text is available yet for this article.
March 2014: Strahlentherapie und Onkologie: Organ der Deutschen Röntgengesellschaft ... [et Al]
Emmanouil Fokas, Cynthia Eccles, Neel Patel, Kwun-Ye Chu, Samantha Warren, W Gillies McKenna, Thomas B Brunner
BACKGROUND AND PURPOSE: Contouring of target volumes varies significantly in radiotherapy of pancreatic ductal adenocarcinoma (PDAC). There is a lack of consensus as to whether elective lymph nodes (eLN's) should be included or not in the planning target volume (PTV). In the present study we analyzed the dosimetric coverage of the eLN's and organs at risk (OAR) by comparing four different contouring guidelines. METHODS AND MATERIALS: PTVs were delineated with (Oxford and RTOG guidelines) or without (Michigan and SCALOP guidelines) including the eLNs in eleven patients with PDAC...
May 2013: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
E Fokas, C Eccles, N Patel, K-Y Chu, S Warren, W Gillies McKenna, T B Brunner
BACKGROUND AND PURPOSE: Target volume definitions for radiotherapy in pancreatic ductal adenocarcinoma (PDAC) vary substantially. Some groups aim to treat the primary tumor only, whereas others include elective lymph nodes (eLNs). eLNs close to the primary tumor are often included unintentionally within the treatment volume, depending on the respective treatment philosophies. We aimed to measure the percentages of anatomical coverage of eLNs by comparing four different contouring guidelines...
May 2013: Strahlentherapie und Onkologie: Organ der Deutschen Röntgengesellschaft ... [et Al]
Somnath Mukherjee, Christopher N Hurt, John Bridgewater, Stephen Falk, Sebastian Cummins, Harpreet Wasan, Tom Crosby, Catherine Jephcott, Rajarshi Roy, Ganesh Radhakrishna, Alec McDonald, Ruby Ray, George Joseph, John Staffurth, Ross A Abrams, Gareth Griffiths, Tim Maughan
BACKGROUND: In the UK, chemotherapy is the standard treatment for inoperable, locally advanced, non-metastatic pancreatic cancer. Chemoradiotherapy is also an acceptable treatment option, for which gemcitabine, fluorouracil, or capecitabine can be used as concurrent chemotherapy agents. We aimed to assess the activity, safety, and feasibility of both gemcitabine-based and capecitabine-based chemoradiotherapy after induction chemotherapy for patients with locally advanced pancreatic cancer...
April 2013: Lancet Oncology
L Bourdais, A Hamel, O Hamel, M Pannier, F Duteille
We report a case of reconstruction of a dysplasic thoracic spine with vascularized fibula in Recklinghausen's disease. We present the case of a thirteen-year-old lady with neurofibromatosis type 1 who developed a dystrophic thoracic kyphoscoliosis. A T9 compression due to a severe scaloping of the thoracic spine caused an important deformation and a medullar compression (with dorsal pain, right sciatica and a pyramidal syndrome). The surgery consisted in medullar liberation by a T9-T10 corporectomy and an osteosynthesis with arthrodesis T3-L3...
June 2008: Annales de Chirurgie Plastique et Esthétique
Mehmed Kulić, Sanko Pandur, Haris Vila, Faida Kueukalić, Vladimir Velebit, Marko Buksa
INTRODUCTION: Intraoperative transesophageal echocardiography (TEE) is a useful tool during valvular, great vessels and CABG surgery. In several large studies TEE has been shown to have higer sensitivity than TTE for native valve (94-100% vs. 44-63%) and prosthetic valves (75% vs 25%) both have high specificity (91-98%). TEE has got its value, particularly when surgeon intends to repair diseased valves, which are favorable operations due to its better survival rate, better ventricular function and fewer tromboembolic events...
2005: Medicinski Arhiv
M Pasquino, V Casanova Borca, S Tofani
INTRODUCTION: In the present paper we discuss the main dosimetric characteristics of the multileaf collimator (MLC) installed on the Elekta SLi Precise accelerators. To evaluate the effectiveness of the MLC in conformal radiotherapy, beam transmission through leaves and/or diaphragms, leakage between the leaves, central axis depth dose, surface dose, effective penumbra, scalopping effect and field size factors were measured. MATERIALS AND METHODS: The MLC installed on the dual energy (4 and 6 MV) linear accelerator Elekta SLi Precise consists of 40 opposed pairs of 75 mm thick tungsten leaves, set in two raws mounted in place of the upper collimator...
March 2001: La Radiologia Medica
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