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https://www.readbyqxmd.com/read/28106815/social-dysfunction-and-diet-outcomes-in-people-with-psychosis
#1
Doreen Mucheru, Mary-Claire Hanlon, Linda E Campbell, Mark McEvoy, Lesley MacDonald-Wicks
This analysis aimed to examine the association of social dysfunction with food security status, fruit intake, vegetable intake, meal frequency and breakfast consumption in people with psychosis from the Hunter New England (HNE) catchment site of the Survey of High Impact Psychosis (SHIP). Social dysfunction and dietary information were collected using standardised tools. Independent binary logistic regressions were used to examine the association between social dysfunction and food security status, fruit intake, vegetable intake, meal frequency and breakfast consumption...
January 19, 2017: Nutrients
https://www.readbyqxmd.com/read/28100764/drip-n-ship-versus-mothership-for-endovascular-treatment-modeling-the-best-transportation-options-for-optimal-outcomes
#2
Matthew S W Milne, Jessalyn K Holodinsky, Michael D Hill, Anders Nygren, Chao Qiu, Mayank Goyal, Noreen Kamal
BACKGROUND AND PURPOSE: There is uncertainty regarding the best way for patients outside of endovascular-capable or Comprehensive Stroke Centers (CSC) to access endovascular treatment for acute ischemic stroke. The role of the nonendovascular-capable Primary Stroke Centers (PSC) that can offer thrombolysis with alteplase but not endovascular treatment is unclear. A key question is whether average benefit is greater with early thrombolysis at the closest PSC before transportation to the CSC (Drip 'n Ship) or with PSC bypass and direct transport to the CSC (Mothership)...
January 18, 2017: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/28100417/long-range-and-regional-transported-size-resolved-atmospheric-aerosols-during-summertime-in-urban-shanghai
#3
Xiaoxiao Ding, Lingdong Kong, Chengtian Du, Assiya Zhanzakova, Lin Wang, Hongbo Fu, Jianmin Chen, Xin Yang, Tiantao Cheng
In this study, the concentrations of water soluble ions (WSI), organic carbon (OC), and elemental carbon (EC) of size-resolved (0.056-18μm) atmospheric aerosols were measured in July and August 2015 in Shanghai, China. Backward trajectory model and potential source contribution function (PSCF) model were used to identify the potential source distributions of size-resolved particles and PM1.8-associated atmospheric inorganic and carbonaceous aerosols. The results showed that the average mass concentrations of PM0...
January 15, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28090274/the-role-of-m2000-as-an-anti-inflammatory-agent-in-toll-like-receptor-2-microrna-155-pathway
#4
Fatemeh Pourgholi, Mahsa Hajivalili, Rasoul Razavi, Shadi Esmaeili, Behzad Baradaran, Ali Akbar Movasaghpour, Sanam Sadreddini, Hamidreza Goodarzynejad, Abbas Mirshafiey, Mehdi Yousefi
BACKGROUND: M2000 is a newly designed and safe Non-Steroidal Anti-Inflammatory Drug (NSAID). The aim of this study was to assess the effects of M2000 on expression levels of Suppressor of Cytokine Signaling-1 (SOCS-1) and Src Homology-2 domain-containing inositol-5'-phosphatase 1 (SHIP1) proteins via Toll-Like Receptor (TLR) 2/microRNA-155 pathway. METHODS: HEK293 TLR2 cell line and Peripheral Blood Mononuclear Cells (PBMCs) were treated by different concentrations of M2000 in MTT assay...
January 2017: Avicenna Journal of Medical Biotechnology
https://www.readbyqxmd.com/read/28089207/delivery-dilemmas-how-drug-cryptomarket-users-identify-and-seek-to-reduce-their-risk-of-detection-by-law-enforcement
#5
Judith Aldridge, Rebecca Askew
BACKGROUND: Cryptomarkets represent an important drug market innovation by bringing buyers and sellers of illegal drugs together in a 'hidden' yet public online marketplace. We ask: How do cryptomarket drug sellers and buyers perceive the risks of detection and arrest, and attempt to limit them? METHODS: We analyse selected texts produced by vendors operating on the first major drug cryptomarket, Silk Road (N=600) alongside data extracted from the marketplace discussion forum that include buyer perspectives...
January 11, 2017: International Journal on Drug Policy
https://www.readbyqxmd.com/read/28088044/dried-haematic-microsamples-and-lc-ms-ms-for-the-analysis-of-natural-and-synthetic-cannabinoids
#6
Michele Protti, James Rudge, Angelo Eliseo Sberna, Gilberto Gerra, Laura Mercolini
Synthetic cannabinoids are new psychoactive substances (NPS) with similar effects when compared to natural ones found in Cannabis derivatives. They have rapidly integrated into the illicit market, often sold as alternatives under international control. The need to identify and quantify an unprecedented and growing number of new compounds represents a unique challenge for toxicological, forensic and anti-doping analysis. Dried blood spots have been used within the bioanalytical framework in place of plasma or serum, in order to reduce invasiveness, lower sample size, simplify handling, storage and shipping of samples and to facilitate home-based and on-field applications...
December 30, 2016: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/28079370/substituted-polyesters-by-thiol-ene-modification-rapid-diversification-for-therapeutic-protein-stabilization
#7
Emma M Pelegri-O'Day, Samantha J Paluck, Heather D Maynard
Many proteins, especially those used as therapeutics, are unstable to storage and shipping temperatures, leading to increased costs in research and industry. Therefore, the design and synthesis of novel stabilizers is an important area of investigation. Herein we report new degradable polymers that stabilize proteins to environmental stressors such as refrigeration and elevated temperature. Specifically, polycaprolactones with different pendant groups were synthesized and surveyed for their ability to stabilize an important therapeutic protein to storage and shipping conditions...
January 12, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28077695/stability-studies-on-dry-swabs-and-wet-mailed-swabs-for-the-detection-of-c-trachomatis-and-n-gonorrhoeae-in-the-aptima-assays
#8
Jeanne Moncada, Carey B Clark, Jeffrey Holden, Edward W Hook, Charlotte A Gaydos, Julius Schachter
The Aptima Combo2 (AC2) and Aptima CT (ACT) (Hologic Inc., San Diego, CA) are nucleic acid amplified tests (NAATs) that detect Chlamydia trachomatis (CT). AC2 also detects Neisseria gonorrhoeae (NG). Storage and temperature conditions may impact the utility of NAATs in some settings and screening programs. We evaluated specimen stability for use beyond the Aptima package insert temperature and duration of storage specifications (between 2° to 30°C, 60 days) in two studies: 1) dry CT seeded swabs were used with ACT after storage at 4°C, 23°C or 36°C for up to 84 days and 2) swabs seeded with CT and NG then placed in transport media were tested with AC2, after mailing via the U...
January 11, 2017: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/28077609/travellers-and-influenza-risks-and-prevention
#9
REVIEW
M Goeijenbier, P van Genderen, B J Ward, A Wilder-Smith, R Steffen, A D M E Osterhaus
BACKGROUND: Influenza viruses are among the major causes of serious human respiratory tract infection worldwide. In line with the high disease burden attributable to influenza, these viruses play an important, but often neglected, role in travel medicine. Guidelines and recommendations regarding prevention and management of influenza in travellers are scarce. Of special interest for travel medicine are risk populations and also circumstances that facilitate influenza virus transmission and spread, like travel by airplane or cruise ship and mass gatherings...
January 2017: Journal of Travel Medicine
https://www.readbyqxmd.com/read/28077280/engineering-out-the-noise
#10
Kurt Yankaskas, Raymond Fischer, Jesse Spence, Jeff Komrower
The US Navy, through an Office of Naval Research (ONR) lead effort on Noise Induced Hearing Loss (NIHL), is investigating methods and techniques to mitigate hearing loss for the crews and warfighters. Hearing protection is a viable and increasingly popular method of reducing hearing exposure for many ship crewmembers; however, it has limitations on comfort and low frequency effectiveness. Furthermore, Personal Hearing Protection (PHP) is often used improperly. Proper vessel planning, programmatic changes and advances in noise control engineering can also have significant impacts by inherently reducing noise exposure through ship design and use of noise control treatments...
January 7, 2017: Hearing Research
https://www.readbyqxmd.com/read/28075049/src-homology-2-domain-containing-inositol-5-phosphatase-ameliorates-high-glucose-induced-extracellular-matrix-deposition-via-the-phosphatidylinositol-3-kinase-protein-kinase-b-pathway-in-renal-tubular-epithelial-cells
#11
Fan Li, Lisha Li, Jun Hao, Shuxia Liu, Huijun Duan
A typical hallmark of diabetic kidney disease (DKD) is an excessive deposition of extracellular matrix (ECM) in the glomerulus and renal tubulointerstitium, leading to glomerulosclerosis and tubular interstitial fibrosis. Src homology 2 domain-containing inositol 5'-phosphatase (SHIP) is a negative regulator of the phosphatidylinositol 3-kinase/protein kinase B (PI3K/Akt) signaling. Here, we investigated the effect of SHIP on ECM deposition in diabetic mice and high glucose-stimulated human renal tubular epithelial cells (HK2 cells)...
January 11, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/28074955/total-synthesis-and-biological-activity-of-dolastatin-16
#12
Loida O Casalme, Arisa Yamauchi, Akinori Sato, Julie G Petitbois, Yasuyuki Nogata, Erina Yoshimura, Tatsufumi Okino, Taiki Umezawa, Fuyuhiko Matsuda
The total synthesis of dolastatin 16, a macrocyclic depsipeptide first isolated from the sea hare Dolabella auricularia as a potential antineoplastic metabolite by Pettit et al., was achieved in a convergent manner. Dolastatin 16 was reported by Tan to exhibit strong antifouling activity, and thus shows promise for inhibiting the attachment of marine benthic organisms such as Amphibalanus amphitrite to ships and submerged artificial structures. Therefore, dolastatin 16 is a potential compound for a new, environmentally friendly antifouling material to replace banned tributyltin-based antifouling paints...
January 11, 2017: Organic & Biomolecular Chemistry
https://www.readbyqxmd.com/read/28073496/the-re-eutrophication-of-lake-erie-harmful-algal-blooms-and-hypoxia
#13
REVIEW
Susan B Watson, Carol Miller, George Arhonditsis, Gregory L Boyer, Wayne Carmichael, Murray N Charlton, Remegio Confesor, David C Depew, Tomas O Höök, Stuart A Ludsin, Gerald Matisoff, Shawn P McElmurry, Michael W Murray, R Peter Richards, Yerubandi R Rao, Morgan M Steffen, Steven W Wilhelm
Lake Erie supplies drinking water to more than 11 million consumers, processes millions of gallons of wastewater, provides important species habitat and supports a substantial industrial sector, with >$50 billion annual income to tourism, recreational boating, shipping, fisheries, and other industries. These and other key ecosystem services are currently threatened by an excess supply of nutrients, manifested in particular by increases in the magnitude and extent of harmful planktonic and benthic algal blooms (HABs) and hypoxia...
June 2016: Harmful Algae
https://www.readbyqxmd.com/read/28073425/hypertension-in-germany
#14
Hannelore Neuhauser, Claudia Diederichs, Heiner Boeing, Stephan B Felix, Claus Jünger, Roberto Lorbeer, Christine Meisinger, Annette Peters, Henry Völzke, Cornelia Weikert, Philipp Wild, Marcus Dörr
BACKGROUND: Hypertension is a key risk factor. However, population data based on blood pressure measurements in Germany are scarce. METHODS: Standardized blood pressure (BP) measurements and medication data from seven population-based studies conducted in Germany between 1994 and 2012 (66 845 participants, 25-74 years) were analyzed: the EPICPotsdam study (1994-1998, EPIC), the KORA-S4 Study (1999-2001) in Augsburg, and the Gutenberg Health Study (2007-2012, GHS) in Mainz/Mainz-Bingen provided data for descriptive comparisons...
December 2, 2016: Deutsches Ärzteblatt International
https://www.readbyqxmd.com/read/28073022/ocean-depths-the-mesopelagic-and-implications-for%C3%A2-global-warming
#15
Mark J Costello, Sean Breyer
The mesopelagic or 'twilight zone' of the oceans occurs too deep for photosynthesis, but is a major part of the world's carbon cycle. Depth boundaries for the mesopelagic have now been shown on a global scale using the distribution of pelagic animals detected by compiling echo-soundings from ships around the world, and been used to predict the effect of global warming on regional fish production.
January 9, 2017: Current Biology: CB
https://www.readbyqxmd.com/read/28072520/bioenergy-potential-from-food-waste-in-california
#16
Hanna Marie Breunig, Ling Jin, Alastair Robinson, Corinne Donahue Scown
Food waste makes up approximately 15% of municipal solid waste generated in the United States, and 95% is ultimately landfilled. Its bioavailable carbon and nutrient content makes it a major contributor to landfill methane emissions, but also presents an important opportunity for energy recovery. This paper presents the first detailed analysis of monthly food waste generation in California at a county level, and its potential contribution to the state's energy production. We develop and analyze a set of scenarios that rely on excess capacity at existing anaerobic digester (AD) and solid biomass combustion facilities, and alternatives that allow for new facility construction...
January 10, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/28068456/an-evidential-reasoning-based-cream-to-human-reliability-analysis-in-maritime-accident-process
#17
Bing Wu, Xinping Yan, Yang Wang, C Guedes Soares
This article proposes a modified cognitive reliability and error analysis method (CREAM) for estimating the human error probability in the maritime accident process on the basis of an evidential reasoning approach. This modified CREAM is developed to precisely quantify the linguistic variables of the common performance conditions and to overcome the problem of ignoring the uncertainty caused by incomplete information in the existing CREAM models. Moreover, this article views maritime accident development from the sequential perspective, where a scenario- and barrier-based framework is proposed to describe the maritime accident process...
January 9, 2017: Risk Analysis: An Official Publication of the Society for Risk Analysis
https://www.readbyqxmd.com/read/28066123/moving-from-trust-to-trustworthiness-experiences-of-public-engagement-in-the-scottish-health-informatics-programme
#18
Mhairi Aitken, Sarah Cunningham-Burley, Claudia Pagliari
The Scottish Health Informatics Programme (SHIP) was a Scotland-wide research programme exploring ways of collecting, managing and analysing electronic patient records for health research. As part of the SHIP public engagement work stream, a series of eight focus groups and a stakeholder workshop were conducted to explore perceptions of the role, relevance and functions of trust (or trustworthiness) in relation to research practices. The findings demonstrate that the public's relationships of trust and/or mistrust in science and research are not straightforward...
October 2016: Science & Public Policy
https://www.readbyqxmd.com/read/28065572/uneven-distribution-of-inorganic-pollutants-in-marine-air-originating-from-ocean-going-ships
#19
László Bencs, Benjamin Horemans, Anna Jolanta Buczyńska, René Van Grieken
The distribution of mass, water-soluble inorganic salts and mineral elements of size-segregated aerosols (PM1, PM2.5-1 and PM10-2.5), precursor gaseous pollutants, black carbon, and nanoparticles (10-300 nm size range) at the Southern Bight of the North Sea has been studied. The concentrations of air pollutants peaked over shipping lanes, open-water anchorage areas and frequently navigated waters, due to the presence of mobile emission sources. A considerable decrease in air pollutant levels was seen when diverting from these marine areas towards remote or coastal banks...
January 5, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/28062859/outcomes-after-direct-thrombectomy-or-combined-intravenous-and-endovascular-treatment-are-not-different
#20
Sònia Abilleira, Aida Ribera, Pedro Cardona, Marta Rubiera, Elena López-Cancio, Sergi Amaro, Ana Rodríguez-Campello, Pol Camps-Renom, David Cánovas, Maria Angels de Miquel, Alejandro Tomasello, Sebastian Remollo, Antonio López-Rueda, Elio Vivas, Joan Perendreu, Miquel Gallofré
BACKGROUND AND PURPOSE: Whether intravenous thrombolysis adds a further benefit when given before endovascular thrombectomy (EVT) is unknown. Furthermore, intravenous thrombolysis delays time to groin puncture, mainly among drip and ship patients. METHODS: Using region-wide registry data, we selected cases that received direct EVT or combined intravenous thrombolysis+EVT for anterior circulation strokes between January 2011 and October 2015. Treatment effect was estimated by stratification on a propensity score...
January 6, 2017: Stroke; a Journal of Cerebral Circulation
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