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https://www.readbyqxmd.com/read/29140658/killing-u-s-slowly-curing-the-epidemic-rise-of-cancer-drug-prices
#1
Emily K White
In August 2015, more than 110 U.S. oncologists published an article detailing the deleterious effects of rising cancer drugs prices and calling for numerous reforms to our prescription drug system. These prices are the result of decades of political maneuvering; they reflect the way our country has chosen to pay for healthcare, to foster and reward innovation, and to promote a national free market system. While these choices have resulted in immense profits for pharmaceutical companies—and subsidized the development of prescription drugs globally—they have also left many cancer patients unable to afford their medications...
2017: Food and Drug Law Journal
https://www.readbyqxmd.com/read/29137663/patent-landscape-of-neglected-tropical-diseases-an-analysis-of-worldwide-patent-families
#2
Folahanmi Tomiwa Akinsolu, Vitor Nobre de Paiva, Samuel Santos Souza, Orsolya Varga
BACKGROUND: "Neglected Tropical Diseases" (NTDs) affect millions of people in Africa, Asia and South America. The two primary ways of strategic interventions are "preventive chemotherapy and transmission control" (PCT), and "innovative and intensified disease management" (IDM). In the last 5 years, phenomenal progress has been achieved. However, it is crucial to intensify research effort into NTDs, because of the emerging drug resistance. According to the World Health Organization (WHO), the term NTDs covers 17 diseases, namely buruli ulcer, Chagas disease, dengue, dracunculiasis, echinococcosis, trematodiasis, human African trypanosomiasis, leishmaniasis, leprosy, lymphatic filariasis, onchocerciasis, rabies, schistosomiasis, soil-transmitted helminthes, taeniasis, trachoma, and yaws...
November 14, 2017: Globalization and Health
https://www.readbyqxmd.com/read/29117510/mems-devices-for-drug-delivery
#3
Hyunjoo J Lee, Nakwon Choi, Eui-Sung Yoon, Il-Joo Cho
Novel drug delivery systems based on microtechnology have advanced tremendously, but yet face some technological and societal hurdles to fully achieve their potential. The novel drug delivery systems aim to deliver drugs in a spatiotemporal- and dosage-controlled manner with a goal to address the unmet medical needs from oral delivery and hypodermic injection. The unmet needs include effective delivery of new types of drug candidates that are otherwise insoluble and unstable, targeted delivery to areas protected by barriers (e...
November 5, 2017: Advanced Drug Delivery Reviews
https://www.readbyqxmd.com/read/29113472/cell-therapy-for-parkinson-s-disease
#4
Takao Yasuhara, Masahiro Kameda, Tatsuya Sasaki, Naoki Tajiri, Isao Date
Cell therapy for Parkinson's disease (PD) began in 1979 with the transplantation of fetal rat dopamine-containing neurons that improved motor abnormalities in the PD rat model with good survival of grafts and axonal outgrowth. Thirty years have passed since the 2 clinical trials using cell transplantation for PD patients were first reported. Recently, cell therapy is expected to develop as a realistic treatment option for PD patients owing to the advancement of biotechnology represented by pluripotent stem cells...
September 2017: Cell Transplantation
https://www.readbyqxmd.com/read/29112941/yoga-can-improve-assisted-reproduction-technology-outcomes-in-couples-with-infertility
#5
Sara Darbandi, Mahsa Darbandi, Hamid Reza Khorram Khorshid, Mohammad Reza Sadeghi
Context • Depending on the cause of the infertility, nonsurgical or surgical treatments may be used to treat men and women with infertility. Despite improved outcomes due to medical advances, assisted reproductive technology (ART) for couples with infertility is sometimes unsuccessful. Success may be affected by the patient's social, psychological, and physical status. Objective • The study examined the effects of yoga-including asanas (yoga poses), pranayama (proper breathing), shavasana, and meditation-on male and female fertility and ART outcomes...
November 7, 2017: Alternative Therapies in Health and Medicine
https://www.readbyqxmd.com/read/29101017/enhanced-oxygen-permeability-in-membrane-bottomed-concave-microwells-for-the-formation-of-pancreatic-islet-spheroids
#6
GeonHui Lee, Yesl Jun, HeeYeong Jang, Junghyo Yoon, JaeSeo Lee, MinHyung Hong, Seok Chung, Dong-Hwee Kim, SangHoon Lee
Oxygen availability is a critical factor in regulating cell viability that ultimately contributes to the normal morphogenesis and functionality of human tissues. Among various cell culture platforms, construction of 3D multicellular spheroids based on microwell arrays has been extensively applied to reconstitute in vitro human tissue models due to its precise control of tissue culture conditions as well as simple fabrication processes. However, an adequate supply of oxygen into the spheroidal cellular aggregation still remains one of the main challenges to producing healthy in vitro spheroidal tissue models...
October 31, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/29089938/evidence-for-widespread-associations-between-neotropical-hymenopteran-insects-and-actinobacteria
#7
Bernal Matarrita-Carranza, Rolando D Moreira-Soto, Catalina Murillo-Cruz, Marielos Mora, Cameron R Currie, Adrián A Pinto-Tomas
The evolutionary success of hymenopteran insects has been associated with complex physiological and behavioral defense mechanisms against pathogens and parasites. Among these strategies are symbiotic associations between Hymenoptera and antibiotic-producing Actinobacteria, which provide protection to insect hosts. Herein, we examine associations between culturable Actinobacteria and 29 species of tropical hymenopteran insects that span five families, including Apidae (bees), Vespidae (wasps), and Formicidae (ants)...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29081766/an-update-on-candida-tropicalis-based-on-basic-and-clinical-approaches
#8
REVIEW
Diana L Zuza-Alves, Walicyranison P Silva-Rocha, Guilherme M Chaves
Candida tropicalis has emerged as one of the most important Candida species. It has been widely considered the second most virulent Candida species, only preceded by C. albicans. Besides, this species has been recognized as a very strong biofilm producer, surpassing C. albicans in most of the studies. In addition, it produces a wide range of other virulence factors, including: adhesion to buccal epithelial and endothelial cells; the secretion of lytic enzymes, such as proteinases, phospholipases, and hemolysins, bud-to-hyphae transition (also called morphogenesis) and the phenomenon called phenotypic switching...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29075239/insight-of-genus-corynebacterium-ascertaining-the-role-of-pathogenic-and-non-pathogenic-species
#9
REVIEW
Alberto Oliveira, Leticia C Oliveira, Flavia Aburjaile, Leandro Benevides, Sandeep Tiwari, Syed B Jamal, Arthur Silva, Henrique C P Figueiredo, Preetam Ghosh, Ricardo W Portela, Vasco A De Carvalho Azevedo, Alice R Wattam
This review gathers recent information about genomic and transcriptomic studies in the Corynebacterium genus, exploring, for example, prediction of pathogenicity islands and stress response in different pathogenic and non-pathogenic species. In addition, is described several phylogeny studies to Corynebacterium, exploring since the identification of species until biological speciation in one species belonging to the genus Corynebacterium. Important concepts associated with virulence highlighting the role of Pld protein and Tox gene...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29064337/david-bowie-and-the-art-of-slow-innovation-a-fast-second-winner-strategy-for-biotechnology-and-precision-medicine-global-development
#10
Vural Özdemir, George P Patrinos
Original ideas and innovation cannot always be ordered like a courier service and delivered fresh to our desk at 9 am. Yet, most creativity-based organizations, careers, and professions, science and biotechnology innovation included, emphasize the speed as the prevailing ideology. But a narrow focus on speed has several and overlooked shortcomings. For example, it does not offer the opportunity to draw from, and stitch together disparate concepts and practices for truly disruptive innovation. Preventing false starts, learning from others' or our own mistakes, and customizing innovations for local community needs are difficult in a speed-hungry innovation ecosystem...
November 2017: Omics: a Journal of Integrative Biology
https://www.readbyqxmd.com/read/29057979/zymophore-identification-enables-the-discovery-of-novel-phenylalanine-ammonia-lyase-enzymes
#11
Nicholas J Weise, Syed T Ahmed, Fabio Parmeggiani, James L Galman, Mark S Dunstan, Simon J Charnock, David Leys, Nicholas J Turner
The suite of biological catalysts found in Nature has the potential to contribute immensely to scientific advancements, ranging from industrial biotechnology to innovations in bioenergy and medical intervention. The endeavour to obtain a catalyst of choice is, however, wrought with challenges. Herein we report the design of a structure-based annotation system for the identification of functionally similar enzymes from diverse sequence backgrounds. Focusing on an enzymatic activity with demonstrated synthetic and therapeutic relevance, five new phenylalanine ammonia lyase (PAL) enzymes were discovered and characterised with respect to their potential applications...
October 20, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29040564/n-cadherin-identifies-human-endometrial-epithelial-progenitor-cells-by-in-vitro-stem-cell-assays
#12
Hong P T Nguyen, L Xiao, James A Deane, Ker-Sin Tan, Fiona L Cousins, Hirotaka Masuda, Carl N Sprung, Anna Rosamilia, Caroline E Gargett
STUDY QUESTION: Is there a specific surface marker that identifies human endometrial epithelial progenitor cells with adult stem cell activity using in vitro assays? SUMMARY ANSWER: N-cadherin isolates clonogenic, self-renewing human endometrial epithelial progenitor cells with high proliferative potential that differentiate into cytokeratin+ gland-like structures in vitro and identifies their location in some cells of gland profiles predominantly in basalis endometrium adjacent to the myometrium...
November 1, 2017: Human Reproduction
https://www.readbyqxmd.com/read/29034944/power-of-protein-trna-functional-assembly-against-aberrant-aggregation
#13
Charles Bou-Nader, Ludovic Pecqueur, David Cornu, Murielle Lombard, Manuela Dezi, Magali Nicaise, Christophe Velours, Marc Fontecave, Djemel Hamdane
Understanding the mechanisms of protein oligomerization and aggregation is a major concern for biotechnology and medical purposes. However, significant challenges remain in determining the mechanism of formation of these superstructures and the environmental factors that can precisely modulate them. Notably the role that a functional ligand plays in the process of protein aggregation is largely unexplored. We herein address these issues with an original flavin-dependent RNA methyltransferase (TrmFO) used as a protein model since this protein employs a complex set of cofactors and ligands for catalysis...
October 25, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/29032356/cell-scientist-to-watch-mahak-sharma
#14
(no author information available yet)
Mahak Sharma graduated with a bachelor's degree in biotechnology from the Guru Gobind Singh Indraprastha University, Delhi, India. She then moved to the laboratory of Steve Caplan at the University of Nebraska Medical Center, Omaha, USA, where she received her PhD in 2009. After post-doctoral research with Michael Brenner at the Department of Rheumatology, Immunology and Allergy at Harvard Medical School, she returned to India in 2011 as an Assistant Professor at the Indian Institute of Science, Education and Research (IISER) in Mohali...
October 15, 2017: Journal of Cell Science
https://www.readbyqxmd.com/read/29029598/a-method-for-named-entity-normalization-in-biomedical-articles-application-to-diseases-and-plants
#15
Hyejin Cho, Wonjun Choi, Hyunju Lee
BACKGROUND: In biomedical articles, a named entity recognition (NER) technique that identifies entity names from texts is an important element for extracting biological knowledge from articles. After NER is applied to articles, the next step is to normalize the identified names into standard concepts (i.e., disease names are mapped to the National Library of Medicine's Medical Subject Headings disease terms). In biomedical articles, many entity normalization methods rely on domain-specific dictionaries for resolving synonyms and abbreviations...
October 13, 2017: BMC Bioinformatics
https://www.readbyqxmd.com/read/28975545/heterologous-expression-purification-and-characterization-of-a-peroxidase-isolated-from-lepidium-draba
#16
Yaser Fattahian, Ali Riahi-Madvar, Reza Mirzaee, Masoud Torkzadeh-Mahani, Gholamreza Asadikaram
Peroxidase is one of the most widely used enzymes in biotechnology and medicine. In the current study, cDNA encoding peroxidase from Lepidium draba (LDP) was cloned and expressed in Escherichia coli BL21 (DE3) cells in the form of inclusion bodies (IBs). To achieve purified active enzyme, IBs were solubilized before being purified and refolded. The deduced amino acid sequence (308) of the LDP gene (924 bp) revealed 88.96% identity to horseradish peroxidase C1A (HRP C1A). The results of basic local alignment search tool (BLAST) and phylogenetic analysis of the protein sequence showed that this enzyme belongs to the neutral group of class III plant peroxidases...
October 3, 2017: Protein Journal
https://www.readbyqxmd.com/read/28949871/morals-or-markets-regulating-assisted-reproductive-technologies-as-morality-or-economic-policies-in-the-states
#17
Erin Heidt-Forsythe
BACKGROUND: The availability of assisted reproductive technologies (ARTs) in the medical marketplace complicates our understanding of reproductive public policy in the United States. Political debates over ARTs often are based on fundamental moral principles of life, reproduction, and kinship, similar to other reproductive policies in the United States. However, ARTs are an important moneymaking private enterprise for the U.S. biotechnology industry. This project investigates how the U...
January 2017: AJOB Empirical Bioethics
https://www.readbyqxmd.com/read/28936894/recent-advances-in-protein-engineering-and-biotechnological-applications-of-glutathione-transferases
#18
Fereniki Perperopoulou, Fotini Pouliou, Nikolaos E Labrou
Glutathione transferases (GSTs, EC 2.5.1.18) are a widespread family of enzymes that play a central role in the detoxification, metabolism, and transport or sequestration of endogenous or xenobiotic compounds. During the last two decades, delineation of the important structural and catalytic features of GSTs has laid the groundwork for engineering GSTs, involving both rational and random approaches, aiming to create new variants with new or altered properties. These approaches have expanded the usefulness of native GSTs, not only for understanding the fundamentals of molecular detoxification mechanisms, but also for the development medical, analytical, environmental, and agricultural applications...
September 22, 2017: Critical Reviews in Biotechnology
https://www.readbyqxmd.com/read/28928611/brugada-syndrome-in-children-stepping-into-unchartered-territory
#19
REVIEW
Shashank P Behere, Steven N Weindling
Brugada syndrome (BrS) is an autosomal dominant inherited channelopathy. It is associated with a typical pattern of ST-segment elevation in the precordial leads V1-V3 and potentially lethal ventricular arrhythmias in otherwise healthy patients. It is frequently seen in young Asian males, in whom it has previously been described as sudden unexplained nocturnal death syndrome. Although it typically presents in young adults, it is also known to present in children and infants, especially in the presence of fever...
September 2017: Annals of Pediatric Cardiology
https://www.readbyqxmd.com/read/28921339/biotechnological-production-of-value-added-compounds-by-ustilaginomycetous-yeasts
#20
REVIEW
Bruno N Paulino, Marina G Pessôa, Gustavo Molina, Antônio A Kaupert Neto, Juliana V C Oliveira, Mario C R Mano, Glaucia M Pastore
The use of yeasts in bioprocesses can be considered one of the most relevant strategies in industrial biotechnology, and their potential is recognized due to the ability of these microorganisms for production of diverse value-added compounds. Yeasts from Ustilaginaceae family have been highlighted in the last years as a promising source of industrial interesting compounds, including enzymes, sugars, lipids, organic acids, and biosurfactants. These compounds may exhibit various applications in pharmaceutical, cosmetic, food, medical, and environmental fields, increasing the scientific attention in the study of ustilaginomycetous for biotechnological purposes...
September 18, 2017: Applied Microbiology and Biotechnology
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