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https://www.readbyqxmd.com/read/28936894/recent-advances-in-protein-engineering-and-biotechnological-applications-of-glutathione-transferases
#1
Fereniki Perperopoulou, Fotini Pouliou, Nikolaos E Labrou
Glutathione transferases (GSTs, EC 2.5.1.18) are a widespread family of enzymes that play a central role in the detoxification, metabolism, and transport or sequestration of endogenous or xenobiotic compounds. During the last two decades, delineation of the important structural and catalytic features of GSTs has laid the groundwork for engineering GSTs, involving both rational and random approaches, aiming to create new variants with new or altered properties. These approaches have expanded the usefulness of native GSTs, not only for understanding the fundamentals of molecular detoxification mechanisms, but also for the development medical, analytical, environmental, and agricultural applications...
September 22, 2017: Critical Reviews in Biotechnology
https://www.readbyqxmd.com/read/28928611/brugada-syndrome-in-children-stepping-into-unchartered-territory
#2
REVIEW
Shashank P Behere, Steven N Weindling
Brugada syndrome (BrS) is an autosomal dominant inherited channelopathy. It is associated with a typical pattern of ST-segment elevation in the precordial leads V1-V3 and potentially lethal ventricular arrhythmias in otherwise healthy patients. It is frequently seen in young Asian males, in whom it has previously been described as sudden unexplained nocturnal death syndrome. Although it typically presents in young adults, it is also known to present in children and infants, especially in the presence of fever...
September 2017: Annals of Pediatric Cardiology
https://www.readbyqxmd.com/read/28921339/biotechnological-production-of-value-added-compounds-by-ustilaginomycetous-yeasts
#3
REVIEW
Bruno N Paulino, Marina G Pessôa, Gustavo Molina, Antônio A Kaupert Neto, Juliana V C Oliveira, Mario C R Mano, Glaucia M Pastore
The use of yeasts in bioprocesses can be considered one of the most relevant strategies in industrial biotechnology, and their potential is recognized due to the ability of these microorganisms for production of diverse value-added compounds. Yeasts from Ustilaginaceae family have been highlighted in the last years as a promising source of industrial interesting compounds, including enzymes, sugars, lipids, organic acids, and biosurfactants. These compounds may exhibit various applications in pharmaceutical, cosmetic, food, medical, and environmental fields, increasing the scientific attention in the study of ustilaginomycetous for biotechnological purposes...
September 18, 2017: Applied Microbiology and Biotechnology
https://www.readbyqxmd.com/read/28916381/perspectives-on-the-production-structural-characteristics-and-potential-applications-of-bioplastics-derived-from-polyhydroxyalkanoates
#4
REVIEW
Priscilla B S Albuquerque, Carolina B Malafaia
Since the last two decades, the use of synthetic materials has increased and become more frequent in this capitalist system. Polymers used as raw materials are usually disposed very rapidly and considered serious damages when they return to the environment. Because of this behaviour, there was an increasing in the global awareness by minimizing the waste generated, in addition to the scientific community concern for technological alternatives to solve this problem. Alternatively, biodegradable polymers are attracting special interest due to their inherent properties, which are similar to the ones of the conventional plastics...
September 12, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28912772/an-anthropocentric-view-of-the-virosphere-host-relationship
#5
Rodrigo A L Rodrigues, Ana C Dos S P Andrade, Paulo V de M Boratto, Giliane de S Trindade, Erna G Kroon, Jônatas S Abrahão
For over a century, viruses have been known as the most abundant and diverse group of organisms on Earth, forming a virosphere. Based on extensive meta-analyses, we present, for the first time, a wide and complete overview of virus-host network, covering all known viral species. Our data indicate that most of known viral species, regardless of their genomic category, have an intriguingly narrow host range, infecting only 1 or 2 host species. Our data also show that the known virosphere has expanded based on viruses of human interest, related to economical, medical or biotechnological activities...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28900375/expression-and-purification-of-untagged-glnk-proteins-from-actinobacteria
#6
Edileusa C M Gerhardt, Vivian R Moure, Andrey W Souza, Fabio O Pedrosa, Emanuel M Souza, Lautaro Diacovich, Hugo Gramajo, Luciano F Huergo
The PII protein family constitutes one of the most conserved and well distributed family of signal transduction proteins in nature. These proteins play key roles in nitrogen and carbon metabolism. PII function has been well documented in Gram-negative bacteria. However, there are very few reports describing the in vitro properties and function of PII derived from Gram-positive bacteria. Here we present the heterologous expression and efficient purification protocols for untagged PII from three Actinobacteria of medical and biotechnological interest namely: Mycobacterium tuberculosis, Rhodococcus jostii and Streptomyces coelicolor...
2017: EXCLI journal
https://www.readbyqxmd.com/read/28888551/amino-acids-production-focusing-on-fermentation-technologies-a-review
#7
REVIEW
Martina D'Este, Merlin Alvarado-Morales, Irini Angelidaki
Amino acids are attractive and promising biochemicals with market capacity requirements constantly increasing. Their applicability ranges from animal feed additives, flavour enhancers and ingredients in cosmetic to specialty nutrients in pharmaceutical and medical fields. This review gives an overview of the processes applied for amino acids production and points out the main advantages and disadvantages of each. Due to the advances made in the genetic engineering techniques, the biotechnological processes, and in particular the fermentation with the aid of strains such as Corynebacterium glutamicum or Escherichia coli, play a significant role in the industrial production of amino acids...
September 6, 2017: Biotechnology Advances
https://www.readbyqxmd.com/read/28885940/collaborative-systems-biology-projects-for-the-military-medical-community
#8
Jeffrey J Zalatoris, Julia B Scheerer, Frank J Lebeda
INTRODUCTION: This pilot study was conducted to examine, for the first time, the ongoing systems biology research and development projects within the laboratories and centers of the U.S. Army Medical Research and Materiel Command (USAMRMC). The analysis has provided an understanding of the breadth of systems biology activities, resources, and collaborations across all USAMRMC subordinate laboratories. METHODS: The Systems Biology Collaboration Center at USAMRMC issued a survey regarding systems biology research projects to the eight U...
September 2017: Military Medicine
https://www.readbyqxmd.com/read/28879858/crispr-mediated-genome-engineering-and-its-application-in-industry
#9
Saeed Kaboli, Hasan Babazada
The CRISPR (clustered regularly interspaced short palindromic repeat)-Cas9 (CRISPR-associated nuclease 9) method has been dramatically changing the field of genome engineering. It is a rapid, highly efficient and versatile tool for precise modification of genome that uses a guide RNA (gRNA) to target Cas9 to a specific sequence. This novel RNA-guided genome-editing technique has become a revolutionary tool in biomedical science and has many innovative applications in different fields. In this review, we briefly introduce the Cas9-mediated genome-editing tool, summarize the recent advances in CRISPR/Cas9 technology to engineer the genomes of a wide variety of organisms, and discuss their applications to treatment of fungal and viral disease...
September 7, 2017: Current Issues in Molecular Biology
https://www.readbyqxmd.com/read/28870337/research-advances-on-the-multiple-uses-of-moringa-oleifera-a-sustainable-alternative-for-socially-neglected-population
#10
REVIEW
Raimunda Sâmia Nogueira Brilhante, Jamille Alencar Sales, Vandbergue Santos Pereira, Débora de Souza Collares Maia Castelo-Branco, Rossana de Aguiar Cordeiro, Célia Maria de Souza Sampaio, Manoel de Araújo Neto Paiva, João Bosco Feitosa Dos Santos, José Júlio Costa Sidrim, Marcos Fábio Gadelha Rocha
Moringa oleifera Lam (Moringaceae) is a plant with high nutritional and medicinal value. Native to India, it is now widely distributed throughout tropical and subtropical regions of the world. Its different parts are sources of proteins, vitamins and minerals and present different pharmacological and biotechnological potential. Moreover, M. oleifera seeds are widely used in water and effluent treatment, for their coagulation, flocculation and sedimentation properties, their ability of improving water quality, by reducing organic matter and microbial load, with special applicability in intensive animal production systems, such as aquaculture...
July 2017: Asian Pacific Journal of Tropical Medicine
https://www.readbyqxmd.com/read/28857399/status-of-wound-management-in-korea
#11
Sik Namgoong, Seung-Kyu Han
In spite of a period of intense economic, social, and political hardship following the Korean War, the Republic of Korea has made great strides in economic growth over the past half century, and also remarkable progress in the medical field. However, wound research has been slow to take off in South Korea. Meanwhile, as is the case in many countries in Western Europe and North America, South Korea is seeing a steady increase in its aged population. The growth in the geriatric population has in turn brought on more cases of chronic wounds...
August 30, 2017: Wound Repair and Regeneration
https://www.readbyqxmd.com/read/28851745/a-key-regulator-of-the-glycolytic-and-gluconeogenic-central-metabolic-pathways-in-sinorhizobium-meliloti
#12
George C diCenzo, Zahed Muhammed, Magne Østerås, Shelley A P O'Brien, Turlough M Finan
The order Rhizobiales contains numerous agriculturally, biotechnologically, and medically important bacteria including the rhizobia, Agrobacterium, Brucella, and Methylobacterium, among others. These organisms tend to be metabolically versatile, but there has been relatively little investigation into the regulation of their central carbon metabolic pathways. Here, RNA-seq and promoter fusion data are presented to show that the PckR protein is a key regulator of central carbon metabolism in Sinorhizobium meliloti; during growth with gluconeogenic substrates, PckR represses expression of the complete Entner-Doudoroff glycolytic pathway and induces expression of the pckA and fbaB gluconeogenic genes...
August 29, 2017: Genetics
https://www.readbyqxmd.com/read/28846728/carbon-nanotubes-exhibit-fibrillar-pharmacology-in-primates
#13
Simone Alidori, Daniel L J Thorek, Bradley J Beattie, David Ulmert, Bryan Aristega Almeida, Sebastien Monette, David A Scheinberg, Michael R McDevitt
Nanomedicine rests at the nexus of medicine, bioengineering, and biology with great potential for improving health through innovation and development of new drugs and devices. Carbon nanotubes are an example of a fibrillar nanomaterial poised to translate into medical practice. The leading candidate material in this class is ammonium-functionalized carbon nanotubes (fCNT) that exhibits unexpected pharmacological behavior in vivo with important biotechnology applications. Here, we provide a multi-organ evaluation of the distribution, uptake and processing of fCNT in nonhuman primates using quantitative whole body positron emission tomography (PET), compartmental modeling of pharmacokinetic data, serum biomarkers and ex vivo pathology investigation...
2017: PloS One
https://www.readbyqxmd.com/read/28844178/human-hemoglobin-adsorption-onto-colloidal-cerium-oxide-nanoparticles-a-new-model-based-on-zeta-potential-and-spectroscopy-measurements
#14
Sheida Yousefi Mobasherat Jajroud, Mojtaba Falahati, Farnoosh Attar, Ramazan Ali Khavari-Nejad
The nanoparticle (NP)-induced conformational changes of protein and NP agglomeration have gained a remarkable interest in medical and biotechnological area. Herein, the effect of human hemoglobin (Hb) on the colloidal stability of cerium oxide NP (CNP) was investigated by dynamic light scattering (DLS), zeta potential, and TEM analysis. In addition, the effect of CNP on the heme degradation and structural changes of Hb was studied using fluorescence, circular dichroism (CD), and UV-visible (UV-vis) spectroscopic methods...
August 28, 2017: Journal of Biomolecular Structure & Dynamics
https://www.readbyqxmd.com/read/28839426/liver-and-the-defects-of-cholesterol-and-bile-acids-biosynthesis-rare-disorders-many-diagnostic-pitfalls
#15
EDITORIAL
Gaetano Corso, Antonio Dello Russo, Monica Gelzo
In recent decades, biotechnology produced a growth of knowledge on the causes and mechanisms of metabolic diseases that have formed the basis for their study, diagnosis and treatment. Unfortunately, it is well known that the clinical features of metabolic diseases can manifest themselves with very different characteristics and escape early detection. Also, it is well known that the prognosis of many metabolic diseases is excellent if diagnosed and treated early. In this editorial we briefly summarized two groups of inherited metabolic diseases, the defects of cholesterol biosynthesis and those of bile acids...
August 7, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/28838321/a-review-on-plant-importance-biotechnological-aspects-and-cultivation-challenges-of-jojoba-plant
#16
REVIEW
Jameel R Al-Obaidi, Mohammed Farouq Halabi, Nasser S AlKhalifah, Shanavaskhan Asanar, Abdulrahman A Al-Soqeer, M F Attia
Jojoba is considered a promising oil crop and is cultivated for diverse purposes in many countries. The jojoba seed produces unique high-quality oil with a wide range of applications such as medical and industrial-related products. The plant also has potential value in combatting desertification and land degradation in dry and semi-dry areas. Although the plant is known for its high-temperature and high-salinity tolerance growth ability, issues such as its male-biased ratio, relatively late flowering and seed production time hamper the cultivation of this plant...
August 24, 2017: Biological Research
https://www.readbyqxmd.com/read/28829321/designing-of-ground-truth-annotated-dbt-tu-ju-breast-thermogram-database-towards-early-abnormality-prediction
#17
Mrinal Kanti Bhowmik, Usha Rani Gogoi, Gautam Majumdar, Debotosh Bhattacharjee, Dhritiman Datta, Anjan Kumar Ghosh
The advancement of research in a specific area of clinical diagnosis crucially depends on the availability and quality of the radiology and other test related databases accompanied by ground truth and additional necessary medical findings. The paper describes the creation of the Department of Biotechnology-Tripura University-Jadavpur University (DBT-TU-JU) breast thermogram database. The objective of creating the DBT-TU-JU database is to provide a breast thermogram database that is annotated with the ground truth images of the suspicious regions...
August 17, 2017: IEEE Journal of Biomedical and Health Informatics
https://www.readbyqxmd.com/read/28801795/storage-lipid-and-polysaccharide-metabolism-in-yarrowia-lipolytica-and-umbelopsis-isabellina
#18
Marianna Dourou, Panagiotis Mizerakis, Seraphim Papanikolaou, George Aggelis
Complex biochemical mechanisms are being involved in oleaginous microorganisms during storage lipid and polysaccharide metabolism. Detailed biochemical analyses and monitoring of key enzymes involved in carbon metabolism were performed in Yarrowia lipolytica and Umbelopsis isabellina, which are often used as model oleaginous microorganisms. It was found that during the early oleaginous phase, the carbon source (glucose) was channeled to lipid accumulation, but also to polysaccharide biosynthesis. However, during transition from the early to the late oleaginous phase, glucose was exclusively converted to lipids, while in U...
August 11, 2017: Applied Microbiology and Biotechnology
https://www.readbyqxmd.com/read/28769859/adverse-effects-of-antidepressants-for-chronic-pain-a-systematic-review-and-meta-analysis
#19
Carina Riediger, Tibor Schuster, Kristian Barlinn, Sarah Maier, Jürgen Weitz, Timo Siepmann
BACKGROUND: Antidepressants are widely used in the treatment of chronic pain. Applied doses are lower than those needed to unfold an antidepressive effect. While efficacy of antidepressants for chronic pain has been reported in large randomized-controlled trials (RCT), there is inconsistent data on adverse effects and tolerability. We aimed at synthesizing data from RCT to explore adverse effect profiles and tolerability of antidepressants for treatment of chronic pain. METHODS: Systematic literature research and meta-analyses were performed regarding side effects and safety of different antidepressants in the treatment of chronic pain according to Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines...
2017: Frontiers in Neurology
https://www.readbyqxmd.com/read/28766374/biotechnological-production-and-practical-application-of-l-asparaginase-enzyme
#20
Archana Vimal, Awanish Kumar
L-asparaginase is a vital enzyme of medical importance, and renowned as a chemotherapeutic agent. The relevance of this enzyme is not only limited as an anti-cancer agent, it also possesses a wide range of medical application. The application includes the antimicrobial property, treatment of infectious diseases, autoimmune diseases, canine and feline cancer. Apart from the health care industry, its significance is also established in the food sector as a food processing agent to reduce the acrylamide concentration...
August 2, 2017: Biotechnology & Genetic Engineering Reviews
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