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https://www.readbyqxmd.com/read/29773775/case-study-in-international-cooperation-cuba-s-molecular-immunology-center-and-roswell-park-cancer-institute
#1
Rachel Evans, Mary Reid, Brahm Segal, Scott I Abrams, Kelvin Lee
In 1961, the USA severed diplomatic relations with Cuba, and in 1962 an embargo was imposed on trade and financial relations with that country. It was not until five decades later that the USA and Cuba would reestablish relations. This opened the way for the New York State Trade Mission to Cuba in April 2015, during which Cuba's Molecular Immunology Center and Buffalo, New York's Roswell Park Cancer Institute signed a formal agreement that would set in motion biotechnology research collaboration to address one of the most important causes of death in both countries...
April 2018: MEDICC Review
https://www.readbyqxmd.com/read/29773774/us-and-cuban-scientists-forge-collaboration-on-arbovirus-research
#2
Jorge Pérez-Ávila, Maria G Guzmán-Tirado, Jorge Fraga-Nodarse, Gray Handley, James Meegan, Jose L Pelegrino-Martínez de la Cotera, Anthony S Fauci
After December 17, 2014, when the US and Cuban governments announced their intent to restore relations, the two countries participated in various exchange activities in an effort to encourage cooperation in public health, health research and biomedical sciences. The conference entitled Exploring Opportunities for Arbovirus Research Collaboration, hosted at Havana's Hotel Nacional, was part of these efforts and was the first major US-Cuban scientific conference in over 50 years. Its purpose was to share information about current arbovirus research and recent findings, and to explore opportunities for future joint research...
April 2018: MEDICC Review
https://www.readbyqxmd.com/read/29766589/dna-aggregation-induced-by-mg-2-ions-under-different-conditions
#3
REVIEW
Van-Chien Bui, Thi-Huong Nguyen
Cations-induced DNA aggregation can modify the local structure of oligonucleotides and has potential applications in medicine and biotechnology. Here, we used atomic force microscopy to investigate λ-DNA aggregation on Mg2+ -treated glass (Mg2+ /glass) and in Mg2+ solution. Atomic force microscopy topography images showed that some DNA fragments were slightly stacked together on 10 mM Mg2+ /glass and stacked stronger on ≥50 mM Mg2+ /glass. They also showed that DNA aggregated stronger in Mg2+ solution than on Mg2+ /glass, ie, DNAs are strongly stacked and twisted at 10 mM Mg2+ , rolled together at 50 mM Mg2+ , and slightly aggregated to form small particles at 100 mM Mg2+ ...
May 15, 2018: Journal of Molecular Recognition: JMR
https://www.readbyqxmd.com/read/29765029/the-crispr-tool-kit-for-genome-editing-and-beyond
#4
REVIEW
Mazhar Adli
CRISPR is becoming an indispensable tool in biological research. Once known as the bacterial immune system against invading viruses, the programmable capacity of the Cas9 enzyme is now revolutionizing diverse fields of medical research, biotechnology, and agriculture. CRISPR-Cas9 is no longer just a gene-editing tool; the application areas of catalytically impaired inactive Cas9, including gene regulation, epigenetic editing, chromatin engineering, and imaging, now exceed the gene-editing functionality of WT Cas9...
May 15, 2018: Nature Communications
https://www.readbyqxmd.com/read/29742206/advances-in-enzyme-bioelectrochemistry
#5
Andressa R Pereira, Graziela C Sedenho, João C P DE Souza, Frank N Crespilho
Bioelectrochemistry can be defined as a branch of Chemical Science concerned with electron-proton transfer and transport involving biomolecules, as well as electrode reactions of redox enzymes. The bioelectrochemical reactions and system have direct impact in biotechnological development, in medical devices designing, in the behavior of DNA-protein complexes, in green-energy and bioenergy concepts, and make it possible an understanding of metabolism of all living organisms (e.g. humans) where biomolecules are integral to health and proper functioning...
2018: Anais da Academia Brasileira de Ciências
https://www.readbyqxmd.com/read/29735839/survey-of-probiotic-preparations-and-labeling-practices-in-indian-market
#6
Vikas Chandrashekhar Ghattargi, Swapnil H Kalam, Sumeet S Pandit, Shrikant P Pawar, Yogesh S Shouche
A cross-sectional survey was conducted across 320 chemists shop in Pune city for their availability and labeling practices. The questionnaire revealed the data about the most sold probiotic preparations, their mode of sale, and their available forms such as tablet, capsule, and sachet. Top ten probiotic preparations were evaluated for labeling practice as per the existing regulations of the Indian Council of Medical Research-Department of Biotechnology, Indian guidelines. Majority of probiotic preparations were listing the best before date, viability, probiotic organisms, net quantity, and batch number, but none of them mentioned the health claims...
January 2018: Indian Journal of Medical Microbiology
https://www.readbyqxmd.com/read/29733398/pre-pregnancy-fast-food-and-fruit-intake-is-associated-with-time-to-pregnancy
#7
Jessica A Grieger, Luke E Grzeskowiak, Tina Bianco-Miotto, Tanja Jankovic-Karasoulos, Lisa J Moran, Rebecca L Wilson, Shalem Y Leemaqz, Lucilla Poston, Lesley McCowan, Louise C Kenny, Jenny Myers, James J Walker, Robert J Norman, Gus A Dekker, Claire T Roberts
STUDY QUESTION: Is preconception dietary intake associated with reduced fecundity as measured by a longer time to pregnancy (TTP)? SUMMARY ANSWER: Lower intake of fruit and higher intake of fast food in the preconception period were both associated with a longer TTP. WHAT IS KNOWN ALREADY: Several lifestyle factors, such as smoking and obesity, have consistently been associated with a longer TTP or infertility, but the role of preconception diet in women remains poorly studied...
May 4, 2018: Human Reproduction
https://www.readbyqxmd.com/read/29730456/outcome-and-safety-analysis-of-3d-printed-patient-specific-pedicle-screw-jigs-for-complex-spinal-deformities-a-comparative-study
#8
Bhavuk Garg, Manish Gupta, Menaka Singh, Dinesh Kalyanasundaram
BACKGROUND CONTEXT: Spinal deformities are very challenging to treat and have a great risk of neurological complications due to hardware placement during corrective surgery. Various techniques have been introduced to ensure safe and accurate placement of pedicle screws. Patient-specific screw guides with pre-drawn and pre-validated trajectory seems to be an attractive option. PURPOSE: We have focused on developing 3D printing technique for complex spinal deformities in India...
May 3, 2018: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/29710773/recombinant-inga-laurina-trypsin-inhibitor-ilti-production-in-komagataella-phaffii-confirms-its-potential-anti-biofilm-effect-and-reveals-an-anti-tumoral-activity
#9
Fábio C Carneiro, Simone S Weber, Osmar N Silva, Ana Cristina Jacobowski, Marcelo H S Ramada, Maria L R Macedo, Octávio L Franco, Nádia S Parachin
Protease inhibitors have a broad biotechnological application ranging from medical drugs to anti-microbial agents. The Inga laurina trypsin inhibitor (ILTI) previously showed a great in vitro inhibitory effect under the adherence of Staphylococcus species, being a strong candidate for use as an anti-biofilm agent. Nevertheless, this is found in small quantities in its sources, which impairs its utilization at an industrial scale. Within this context, heterologous production using recombinant microorganisms is one of the best options to scale up the recombinant protein production...
April 28, 2018: Microorganisms
https://www.readbyqxmd.com/read/29708658/mining-for-microbial-gems-integrating-proteomics-in-the-postgenomic-natural-product-discovery-pipeline
#10
REVIEW
Chao Du, Gilles P van Wezel
Natural products (NPs) are a major source of compounds for the medical, agricultural and biotechnological industry. Many of these compounds are of microbial origin, and in particular from Actinobacteria or filamentous fungi. To successfully identify novel compounds that correlate to a bioactivity of interest, or discover new enzymes with desired functions, systematic multi-omics approaches have been developed over the years. Bioinformatics tools harness the rapidly expanding wealth of genome sequence information, revealing previously unsuspected biosynthetic diversity...
April 30, 2018: Proteomics
https://www.readbyqxmd.com/read/29707437/expression-and-characterization-of-a-potential-exopolysaccharide-from-a-newly-isolated-halophilic-thermotolerant-bacteria-halomonas-nitroreducens-strain-wb1
#11
Arpitha Chikkanna, Devanita Ghosh, Abhinoy Kishore
The halophilic bacterial strain WB1 isolated from a hydrothermal vent was taxonomically characterized using multiple proxies, as Halomonas nitroreducens strain WB1. When grown on malt extract/yeast extract (MY) medium, it produced large quantities of exopolysaccharide (EPS). The polymer was synthesized at a higher rate during the log and early stationary phases. The anionic polysaccharide is primarily composed of glucose, mannose, and galactose. The studied EPS was highly viscous and had pseudoplastic nature...
2018: PeerJ
https://www.readbyqxmd.com/read/29700549/adsorption-of-phospholipids-at-oil-water-interfaces-during-emulsification-is-controlled-by-stress-relaxation-and-diffusion
#12
Ellen Hildebrandt, Hermann Nirschl, Robbert Jan Kok, Gero Leneweit
Adsorption of phosphatidylcholines at oil/water interfaces strongly deviates from spread monolayers at air/water surfaces. Understanding its nature and consequences could vastly improve applications in medical nanoemulsions and biotechnologies. Adsorption kinetics at interfaces of water with different oil phases were measured by profile analysis tensiometry. Adsorption kinetics for 2 different phospholipids, DPPC and POPC, as well as 2 organic phases, squalene and squalane, show that formation of interfacial monolayers is initially dominated by stress-relaxation in the first minutes...
April 27, 2018: Soft Matter
https://www.readbyqxmd.com/read/29698120/use-of-free-libre-open-source-software-in-sepsis-omics-research-a-bibliometric-comparative-analysis-among-the-united-states-eu-28-member-states-and-china
#13
Nikolaos Evangelatos, Kapaettu Satyamourthy, Georgia Levidou, Helmut Brand, Pia Bauer, Christina Kouskouti, Angela Brand
"-Omics" systems sciences are at the epicenter of personalized medicine and public health, and drivers of knowledge-based biotechnology innovation. Bioinformatics, a core component of omics research, is one of the disciplines that first employed Free/Libre Open Source Software (FLOSS), and thus provided a fertile ground for its further development. Understanding the use and characteristics of FLOSS deployed in the omics field is valuable for future innovation strategies, policy and funding priorities...
April 26, 2018: Omics: a Journal of Integrative Biology
https://www.readbyqxmd.com/read/29687144/phytochemical-and-biotechnological-studies-on-schisandra-chinensis-cultivar-sadova-no-1-a-high-utility-medicinal-plant
#14
Agnieszka Szopa, Marta Klimek-Szczykutowicz, Adam Kokotkiewicz, Anna Maślanka, Agata Król, Maria Luczkiewicz, Halina Ekiert
In the presented work, raw materials (fruits and leaves) and in vitro biomass of a highly productive Schisandra chinensis Sadova No. 1 cultivar (SchS) were evaluated for the production of therapeutically useful schisandra lignans (SL). In vitro cultures of SchS were initiated, followed by extensive optimization studies focused on maximizing secondary metabolite production, with the aim of establishing a sustainable source of SL. Different cultivation systems (agar, agitated, bioreactor), experiment times (10, 20, 30, 40, 50 and 60 days) and plant growth regulators (6-benzyladenine-BA and 1-naphthaleneacetic acid-NAA, from 0 to 3 mg/l) in Murashige-Skoog (MS) medium were tested...
April 23, 2018: Applied Microbiology and Biotechnology
https://www.readbyqxmd.com/read/29685744/update-on-biosimilars-in-inflammatory-bowel-disease-position-and-recommendations-in-mexico
#15
A Mayoral-Zavala, A Esquivel-Aguilar, C M Del Real-Calzada, Y Gutiérrez-Grobe, J Ramos-García, J L Rocha-Ramírez, M F Rojas-Illanes, B Rubio-Martínez, X Sánchez-Chávez, J K Yamamoto-Furusho
The biotechnology-derived medicines known as biosimilars are defined as non-originator treatments that have demonstrated quality, efficacy, and safety comparable to the reference biologic drug. Clinical trials have shown that the infliximab biosimilar, CT-P13, and the candidates for the adalimumab biosimilars, ABP 501 and ZRC 3197, are not significantly different, with respect to efficacy and safety, from the originator drugs in patients with other autoimmune diseases. However, controversy has arisen over the use of biosimilars in inflammatory bowel disease, due to the incipient evidence not only in patients with no previous biotechnology treatment, but also in patients in remission, that could be switched to a biosimilar for non-medical reasons...
April 20, 2018: Revista de Gastroenterología de México
https://www.readbyqxmd.com/read/29685353/structure-of-a-hyperthermostable-carbonic-anhydrase-identified-from-an-active-hydrothermal-vent-chimney
#16
Folmer Fredslund, Martin S Borchert, Jens-Christian N Poulsen, Steen Bennike Mortensen, Mirjam Perner, Wolfgang R Streit, Leila Lo Leggio
Carbonic anhydrases (CAs) are extremely fast enzymes, which have attracted much interest in the past due to their medical relevance and their biotechnological potential. An α-type CA gene was isolated from DNA derived from an active hydrothermal vent chimney, in an effort to identify novel CAs with suitable properties for CO2 capture. The gene product was recombinantly produced and characterized, revealing remarkable thermostability, also in the presence of high ionic strength alkaline conditions, which are used in some CO2 capture applications...
July 2018: Enzyme and Microbial Technology
https://www.readbyqxmd.com/read/29677972/reflection-on-mobile-applications-for-blood-pressure-management-a-systematic-review-on-potential-effects-and-initiatives
#17
Reyhaneh Mohammadi, Movahhedeh Ayatolahi Tafti, Soodabeh Hoveidamanesh, Reza Ghanavati, Omid Pournik
INTRODUCTION: Ischemic heart disease and stroke have been considered as the first global leading cause of death in last decades [1]. Blood pressure (BP) management is one of the easiest ways suggested for preventing and controlling cardiovascular diseases before the patient develops complications and death-following outcomes. Appearance of technology advancements in the health system has motivated researchers and health providers to study its different aspects and applications in order to improve disease prevention and management...
2018: Studies in Health Technology and Informatics
https://www.readbyqxmd.com/read/29670736/expression-of-parathyroid-hormone-related-protein-pthrp-in-ameloblastomas
#18
Rafael Zeballos, Ronell Bologna-Molina, Vanesa Pereira-Prado, Mariana Villarroel-Dorrego
Background: Presence of parathyroid hormone related protein (PTHrP) might suggest that ameloblastomas recapitulate features of the enamel epithelium and induce bone resorption, which would facilitate their growth and local invasion. The aim of this study was to determine the expression of PTHrP in ameloblastomas. Material and Methods: An observational research study was designed including 39 cases of histologically diagnosed ameloblastomas (39 out of 42 patients gave consent for the use of their medical records and all data required for this study)...
February 2018: Journal of Clinical and Experimental Dentistry
https://www.readbyqxmd.com/read/29669998/fluorescent-dendritic-micro-hydrogels-synthesis-analysis-and-use-in-single-cell-detection
#19
Lisa Christadore, Mark W Grinstaff, Scott E Schaus
Hydrogels are of keen interest for a wide range of medical and biotechnological applications including as 3D substrate structures for the detection of proteins, nucleic acids, and cells. Hydrogel parameters such as polymer wt % and crosslink density are typically altered for a specific application; now, fluorescence can be incorporated into such criteria by specific macromonomer selection. Intrinsic fluorescence was observed at λmax 445 nm from hydrogels polymerized from lysine and aldehyde- terminated poly(ethylene glycol) macromonomers upon excitation with visible light...
April 18, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29669592/ggdonto-ontology-as-a-knowledge-base-for-genetic-diseases-and-disorders-of-glycan-metabolism-and-their-causative-genes
#20
Elena Solovieva, Toshihide Shikanai, Noriaki Fujita, Hisashi Narimatsu
BACKGROUND: Inherited mutations in glyco-related genes can affect the biosynthesis and degradation of glycans and result in severe genetic diseases and disorders. The Glyco-Disease Genes Database (GDGDB), which provides information about these diseases and disorders as well as their causative genes, has been developed by the Research Center for Medical Glycoscience (RCMG) and released in April 2010. GDGDB currently provides information on about 80 genetic diseases and disorders caused by single-gene mutations in glyco-related genes...
April 18, 2018: Journal of Biomedical Semantics
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