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Ridker PM

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https://www.readbyqxmd.com/read/28614350/ranking-and-characterization-of-established-bmi-and-lipid-associated-loci-as-candidates-for-gene-environment-interactions
#1
Dmitry Shungin, Wei Q Deng, Tibor V Varga, Jian'an Luan, Evelin Mihailov, Andres Metspalu, Andrew P Morris, Nita G Forouhi, Cecilia Lindgren, Patrik K E Magnusson, Nancy L Pedersen, Göran Hallmans, Audrey Y Chu, Anne E Justice, Mariaelisa Graff, Thomas W Winkler, Lynda M Rose, Claudia Langenberg, L Adrienne Cupples, Paul M Ridker, Nicholas J Wareham, Ken K Ong, Ruth J F Loos, Daniel I Chasman, Erik Ingelsson, Tuomas O Kilpeläinen, Robert A Scott, Reedik Mägi, Guillaume Paré, Paul W Franks
Phenotypic variance heterogeneity across genotypes at a single nucleotide polymorphism (SNP) may reflect underlying gene-environment (G×E) or gene-gene interactions. We modeled variance heterogeneity for blood lipids and BMI in up to 44,211 participants and investigated relationships between variance effects (Pv), G×E interaction effects (with smoking and physical activity), and marginal genetic effects (Pm). Correlations between Pv and Pm were stronger for SNPs with established marginal effects (Spearman's ρ = 0...
June 2017: PLoS Genetics
https://www.readbyqxmd.com/read/19656039/predicting-benefit-from-statins-by-c-reactive-protein-ldl-cholesterol-or-absolute-cardiovascular-risk
#2
RANDOMIZED CONTROLLED TRIAL
Ralph A H Stewart
Evaluation of: Ridker PM, Danielson E, Fonseca FA et al.: Rosuvastatin to prevent vascular events in men and women with elevated C-reactive protein. N. Engl. J. Med. 359, 2195-2207 (2008). The Justification for the Use of Statins in Prevention: an Intervention Trial Evaluating Rosuvastatin (JUPITER) randomized nearly 18,000 subjects with no history of cardiovascular disease and an average or low LDLcholesterol level (<3.4 mmol/l), but a high plasma level of C-reactive protein (CRP; >2 mg/dl), to rosuvastatin 20 mg or placebo daily...
May 2009: Future Cardiology
https://www.readbyqxmd.com/read/19635319/a-male-adolescent-with-left-iliac-thrombophlebitis-and-heterozygosity-for-factor-v-leiden-mutation
#3
Amy E Lovejoy, Ruth A Bush, Alice L Pong, Mary L Hilfiker
The epidemiology of deep vein thrombosis in adolescents has 2 potential associations. First, there is a demonstrated association with a congenital anomaly of the inferior vena cava (Dean SM, Tytle TL. Vas Med. 2006;11:165-169; Schnieider JG, Eynatten MV, Dugi KA, et al. J Intern Med. 2002;252:276-280). Secondly, resistance to activated protein C as a result of factor V Leiden is associated with thromboembolic disease at an early age (Price DT, Ridker PM. Ann Intern Med. 1997;127:895-903). Imaging modalities, central venous catheters, and improved life expectancy for critically and chronically ill children have resulted in an increased diagnosis of thromboembolic disease in the pediatric population (Journeycake MM, Manco-Johnson MJ...
August 2009: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/18287154/commentary-risk-factors-for-progression-of-peripheral-arterial-disease-in-large-and-small-vessels-aboyans-v-criqui-mh-denenberg-jo-knoke-jd-ridker-pm-fronek-a-circulation-2006-113-2623-2629
#4
COMMENT
Boulos Toursarkissian
available at http://www.circ.ahajournals.org/cgi/ content/abstract/113/22/2623.
December 2007: Perspectives in Vascular Surgery and Endovascular Therapy
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