Ayman J Oweida, Laurel Darragh, Andy Phan, David Binder, Shilpa Bhatia, Adam Mueller, Benjamin Van Court, Dallin Milner, David Raben, Richard Woessner, Lynn Heasley, Raphael Nemenoff, Eric Clambey, Sana D Karam
BACKGROUND: Radioresistance represents a major problem in the treatment of head and neck cancer (HNC) patients. To improve response, understanding tumor microenvironmental factors that contribute to radiation resistance is important. Regulatory T cells (Tregs) are enriched in numerous cancers and can dampen the response to radiation by creating an immune-inhibitory microenvironment. The purpose of this study was to investigate mechanisms of Treg modulation by radiation in HNC. METHODS: We utilized an orthotopic mouse model of HNC...
December 1, 2019: Journal of the National Cancer Institute