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https://www.readbyqxmd.com/read/28821986/comparative-analysis-of-the-effects-of-co2-fractional-laser-and-sonophoresis-on-human-skin-penetration-with-5-aminolevulinic-acid
#1
J H Choi, E J Shin, K H Jeong, M K Shin
Successful delivery of a photosensitizer into the skin is an important factor for effective photodynamic therapy (PDT). The effective method to increase drug penetration within short incubation time overcoming skin barrier have been investigated. This study was performed to analyze and compare the effectiveness of ablative fractional laser (FXL) pretreatment and/or sonophoresis for enhancing the penetration of 5-aminolevulinic acid (ALA) into human skin in vivo. Twenty-four identical 1 × 1 cm(2) treatment areas were mapped on the backs of ten healthy male subjects...
August 19, 2017: Lasers in Medical Science
https://www.readbyqxmd.com/read/28820975/features-of-proteolytic-properties-of-tetraphenylporphyrin-complex-with-lanthanide-group-metals
#2
Elena A Tobolkina, Tatiana A Skripnikova, Anna A Starikova, Galina I Shumilova, Andrey A Pendin
Demetallation of metalloporphyrin molecules is one of the essential degradation reactions in photosynthesis. The effect of metalloporphyrin nature on removal of central metals from tetraphenylporphyrin complexes based on lanthanide group metals (Dy, Er, Lu, Ho) has been studied. pH values, at which the metal ions leave the metalloporphyrin complex were established using two-phase spectrophotometric titration with potentiometric pH-control. The pH values decrease with the increase of atomic numbers of lanthanide groups, as well as with increase of 4f-electrons...
August 12, 2017: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/28820580/enhanced-fluorescence-emission-and-singlet-oxygen-generation-of-photosensitizers-embedded-in-injectable-hydrogels-for-imaging-guided-photodynamic-cancer-therapy
#3
Liu-Yuan Xia, Xiaodong Zhang, Meng Cao, Zhan Chen, Fu-Gen Wu
Benefiting from their inherent localized and controlled release properties, hydrogels are ideal delivery systems for therapeutic drugs or nanoparticles. In particular, the applications of hydrogels for the delivery and release of photo-responsive drugs or nanoparticles are receiving increasing attention. However, the effect of the hydrogel matrix on the fluorescence emission and singlet oxygen generation efficiency of the embedded photosensitizers (PSs) has not been clarified. Herein, meso-tetrakis (1-methylpyridinium-4-yl) porphyrin (TMPyP) as a water-soluble PS is encapsulated into an injectable hydrogel formed by glycol chitosan and dibenzaldehyde-terminated telechelic poly(ethylene glycol)...
August 18, 2017: Biomacromolecules
https://www.readbyqxmd.com/read/28820201/co2-electroreduction-performance-of-a-single-transition-metal-atom-supported-on-porphyrin-like-graphene-a-computational-study
#4
Zhongxu Wang, Jingxiang Zhao, Qinghai Cai
Searching for low-cost, efficient, and stable electrocatalysts for CO2 electroreduction (CO2ER) reactions is highly desirable for the reduction of CO2 emission and its conversion into useful products, but remains a great challenge. In this work, single transition metal atoms supported on porphyrin-like graphene catalysts, i.e., TMN4/graphene, acting as electrocatalysts for CO2 reduction were explored by means of comprehensive density functional theory (DFT) computations. Our results revealed that these anchored TM atoms possess high stability due to their strong hybridization with the unsaturated N atoms of the substrate and function as the active sites...
August 18, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28819397/iron-chelators-and-exogenic-photosensitizers-synergy-through-oxidative-stress-gene-expression
#5
Anna Mrozek-Wilczkiewicz, Katarzyna Malarz, Marzena Rams-Baron, Maciej Serda, Daniela Bauer, Franz-Peter Montforts, Alicja Ratuszna, Thomas Burley, Jaroslaw Polanski, Robert Musiol
In non-invasive anticancer photodynamic therapy (PDT), a nontoxic photosensitizer (PS), which is activated by visible light, is used as a magic bullet that selectively destroys cancer cells. Recently, we described the combined therapy of 5-aminolevulinic acid (ALA-PDT) with thiosemicarbazone (TSC), i.e. an iron-chelating agent. This resulted in a strong synergistic effect. Herein, we investigated a novel strategy using a combination of PDT consist of the xenobiotic-porphyrin type PS with TSC. We observed a synergistic effect for all of the pairs of TSC-PS...
2017: Journal of Cancer
https://www.readbyqxmd.com/read/28817256/tailorable-exciton-transport-in-doped-peptide-amphiphile-assemblies
#6
Lee A Solomon, Matthew E Sykes, Yimin A Wu, Richard D Schaller, Gary P Wiederrecht, Harry Christopher Fry
Light-harvesting biomaterials are an attractive target in photovoltaics, photocatalysis, and artificial photosynthesis. Through peptide self-assembly, complex nanostructures can be engineered to study the role of chromophore organization during light absorption and energy transport. To this end, we demonstrate the one-dimensional transport of excitons along naturally occurring, light-harvesting, Zn-protoporphyrin IX chromophores within self-assembled peptide-amphiphile nanofibers. The internal structure of the nanofibers induces packing of the porphyrins into linear chains...
August 17, 2017: ACS Nano
https://www.readbyqxmd.com/read/28815237/induced-polarization-restricts-the-conformational-distribution-of-a-light-harvesting-molecular-triad-in-the-ground-state
#7
Oleg N Starovoytov, Pengzhi Zhang, Piotr Cieplak, Margaret S Cheung
The light-harvesting molecular triad consisting of carotenoid polyene (C), diaryl-porphyrin (P) and pyrrole-fullerene (C60) is a donor-acceptor molecule capable of absorbing incident light in the visible range. Its ability to convert solar energy to electrical excitation and charge separation energy suggests a great potential in real-world applications. The ensemble of its conformations under ambient conditions varies widely according to its electronic state. In previous work, we applied a non-polarizable model to study the conformational distribution of the molecular triad in the ground and charge separated states...
August 17, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28812758/a-metalloporphyrin-based-porous-organic-polymer-as-an-efficient-catalyst-for-the-catalytic-oxidation-of-olefins-and-arylalkanes
#8
Zheng-Dong Ding, Wei Zhu, Tao Li, Rui Shen, Yunxing Li, Zaijun Li, Xuehong Ren, Zhi-Guo Gu
A metalloporphyrin-based porous organic polymer, Mn-PPOP-1, was constructed in high yield via the ketoenamine condensation of robust porphyrin tetraamines (TBPP) with 1,3,5-triformylphloroglucinol. The stable keto-enamine form in the synthesized polymer was unambiguously confirmed by (13)C CP-MAS solid state NMR. Noticeably, besides the high thermal and chemical stability, this material contains both micropores and mesopores, which are favorable for mass transfer in the catalytic application. Mn-PPOP-1 exhibits significantly high catalytic oxidation of olefins and arylalkanes at room temperature...
August 16, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/28809559/on-the-influence-of-the-bridge-on-triplet-state-delocalization-in-linear-porphyrin-oligomers
#9
Sabine Richert, Bart Limburg, Harry L Anderson, Christiane R Timmel
The extent of triplet state delocalization is investigated in rigid linear zinc porphyrin oligomers as a function of interporphyrin bonding characteristics, specifically in meso-meso singly linked and β,meso,β fused structures, using electron paramagnetic resonance techniques. The results are compared with those of earlier measurements on porphyrin oligomers with alkyne linkers exhibiting different preferred conformations. It is shown that dihedral angles near 90° between the porphyrin planes in directly meso-to-meso linked porphyrin oligomers lead to localization of the photoexcited triplet state on a single porphyrin unit, whereas previous work demonstrated even delocalization over two units in meso-to-meso ethyne or butadiyne-bridged oligomers, where the preferred dihedral angles amount to roughly 30° and 0°, respectively...
August 15, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28805370/chirality-transfer-from-chiral-monoamines-to-an-m-phthalic-diamide-linked-zinc-bisporphyrinate-with-a-benzylamide-substituent
#10
Qingyun Hu, Congcong Zhuo, Yong Wang, Chuanjiang Hu, Jianping Lang
An m-phthalic diamide-linked bisporphyrin with a benzylamide substituent has been designed and synthesized. It has two types of carbonyl groups. In the solution of this zinc bisporphyrinate, these carbonyl groups are involved in the formation of two different Zn-O coordination interactions: one is formed between neighboring zinc bisporphyrinates; another is formed within zinc bisporphyrinate. The chirality sensing abilities of this zinc porphyrinate to a number of chiral monoamines have been examined. When zinc bisporphyrinate was mixed with a series of chiral monoamines, the signs of the circular dichroism spectra for the chiral monoamines of the same handedness with an aryl group as the substituent are just opposite to those with an alkyl group as the substituent...
August 14, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/28802858/effect-of-solvent-on-the-electronic-absorption-spectral-properties-of-some-mixed-%C3%AE-octasubstituted-zn-ii-tetraphenylporphyrins
#11
P Bhyrappa, M Sankar
A series of mixed β-octasubstituted Zn(II)-porphyrins, 2,3,12,13-tetra(chloro/cyano/methyl)-5,7,8,10,15,17,18,20-octaphenylporphinato zinc(II), ZnTPP(Ph)4X4 (X=CN, Cl and CH3) have been examined by electronic absorption spectroscopy in various solvents. These Zn(II)-porphyrins exhibited varying degree of red-shift of absorption bands as high as 20-30nm in 'B' band and 50-60nm in longest wavelength band, 'Q(0,0)' band in polar solvents relative to that found in nonpolar solvents. The red-shift of B and Q(0,0) bands showed an unusual trend, ZnTPP(Ph)4(CN)4>ZnTPP(Ph)4(CH3)4>ZnTPP(Ph)4Cl4 but fails to follow an anticipated anodic shift in first porphyrin ring oxidation (vs Ag/AgCl) potential: ZnTPP(Ph)4(CN)4 (1...
July 31, 2017: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/28801930/conformationally-flexible-bis-9-fluorenylidene-porphyrin-diradicaloids
#12
Jishan Wu, Hejian Zhang, Hoa Phan, Tun Seng Herng Herng, Tullimilli Y Gopalakrishna, Wangdong Zeng, Jun Ding
A stable 5,10-bis(9-fluorenylidene)porphyrin (Por-Fl) diradicaloid was synthesized. It shows a quinoidal, saddle-shaped geometry in single crystal but can be thermally populated to triplet diradical both in solution and in solid state. Coordination with Ni2+ ion (Por-Fl-Ni) does not significantly change the contorted conformation but reduces the singlet-triplet gap. Heat-induced geometric change can explain the observed paramagnetic properties as well as unusual hysteresis in SQUID measurements. On the other hand, protonation (Por-Fl-2H+) dramatically changes the conformation while maintains the closed-shell electronic structure...
August 12, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28800232/strategic-design-of-bacteriochlorins-as-possible-dyes-for-photovoltaic-applications
#13
Mannix Padayhag Balanay, Dong Hee Kim
Bacteriochlorin-based dyes, having a push-pull type of configuration similar to the YD2 dye, were theoretically designed based on the modification of the macrocycle and π-conjugated bridge for use in dye-sensitized solar cells. Various parameters were assessed to determine its structure-property relationships, such as the absorption profile based on time-dependent density functional theory, non-linear optical properties from (hyper)polarizability data, ground- and excited-state oxidation potentials, and the electronic properties of the free and adsorbed dyes...
August 11, 2017: Journal of Physical Chemistry. A
https://www.readbyqxmd.com/read/28800197/%C3%AE-functionalized-push-pull-opp-dibenzoporphyrins-as-sensitizers-for-dye-sensitized-solar-cells
#14
Hong Wang, Yi Hu, Shivaraj Yellappa, Michael B Thomas, R G Waruna Jinadasa, Alex Matus, Max Shulman, Francis D'souza
A novel class of β-functionalized push-pull zinc opp-dibenzoporphyrins were designed, synthesized and utilized as sensitizers for dye-sensitized solar cells. Spectral, electrochemical and computational studies were systematically performed to evaluate their spectral coverage, redox behavior and electronic structures. These porphyrins displayed much broader spectral coverage and more facile oxidation upon extension of π-conjugation. Free-energy calculations and femtosecond transient absorption studies (charge injection rate in the range of 1011 s-1) suggest efficient charge injection from the excited singlet state of porphyrin to the conduction band of the TiO2...
August 11, 2017: Chemistry, An Asian Journal
https://www.readbyqxmd.com/read/28795802/covalent-synthesis-of-two-hybrids-composed-of-dawson-type-polyoxometalate-and-porphyrin-with-remarkable-third-order-optical-nonlinearities-reflecting-the-effect-of-polyoxometalates
#15
Hafiz Muhammad Asif, Yunshan Zhou, Lijuan Zhang, Nusrat Shaheen, Di Yang, Jiaqi Li, Yi Long, Arshad Iqbal, Yanqin Li
Two new porphyrin-polyoxometalate hybrids, namely, [(C4H9)4N]10H2[{COHNC(CH2O)3P2V3W15O59}2C44N4H28]·CH3CN 1, bearing two covalent-bonded Wells-Dawson-type polyoxometalates (POMs), and [(C4H9)4N)]5H[COHNC(CH2O)3P2V3W15O59{C44H29N4}]·CH3CN 2, bearing one covalent-bonded POM, have been synthesized and thoroughly characterized by means of elemental analysis, powder XRD, FT-IR, (1)H ((31)P, (51)V) NMR, MALDI-TOF-MS, UV-vis spectra, and cyclic voltammetry measurement. Experimental results demonstrate that while all the compounds show remarkable third-order optical nonlinearities, the hybrids 1 and 2 are superior to their corresponding porphyrin precursors (molecular second hyperpolarizability γ = 8...
August 10, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/28795723/intracellular-iron-and-heme-trafficking-and-metabolism-in-developing-erythroblasts
#16
Martin D Kafina, Barry H Paw
Vertebrate red blood cells (RBCs) arise from erythroblasts in the human bone marrow through a process known as erythropoiesis. Iron uptake is a crucial hallmark, essential for heme biosynthesis in the differentiating erythroblasts, which are dedicated to producing hemoglobin. Erythropoiesis is facilitated by a network of intracellular transport proteins, chaperones, and circulating hormones. Intracellular iron is targeted to the mitochondria for incorporation into a porphyrin ring to form heme and cytosolic iron-sulfur proteins, including Iron Regulatory Protein 1 (IRP1)...
August 10, 2017: Metallomics: Integrated Biometal Science
https://www.readbyqxmd.com/read/28794327/a-reactive-oxygen-nitrogen-species-sensor-fabricated-from-an-electrode-modified-with-a-polymerized-iron-porphyrin-and-a-polymer-electrolyte-membrane
#17
Ryo Matsuoka, Chihiro Kobayashi, Atsushi Nakagawa, Shigeo Aoyagi, Tatsuo Aikawa, Takeshi Kondo, Shigenobu Kasai, Makoto Yuasa
We have developed an electrochemical reactive oxygen/nitrogen species sensor that can detect superoxide anion radicals (O2(-•)) and nitric oxide (NO). The reactive oxygen/nitrogen species sensor was fabricated by surface modification of an electrode with polymerized iron tetrakis(3-thienyl)porphyrin (FeT3ThP), and it can detect either O2(-•) or NO by switching the applied potential. Furthermore, we fabricated a sensor with improved selectivity by coating a Nafion(®) film onto the poly(FeT3ThP)-modified electrode...
2017: Analytical Sciences: the International Journal of the Japan Society for Analytical Chemistry
https://www.readbyqxmd.com/read/28793202/differential-inhibition-of-rat-and-mouse-microsome-heme-oxygenase-by-derivatives-of-imidazole-and-benzimidazole
#18
Maaike Hum, Brian E McLaughlin, Xianqi Kong, Jason Z Vlahakis, Dragic Vukomanovic, Walter A Szarek, Kanji Nakatsu
Metalloporphyrin, heme oxygenase (HO) inhibitors have made an important contribution to elucidating the role of HO in physiological processes. Nevertheless, their off-target effects have drawn substantial criticism, which prompted us to develop non-porphyrin, azole-based inhibitors of HO. These second-generation HO inhibitors were evaluated using spleen and brain microsomes from rats as native sources of HO-1 and HO-2, respectively. Recently, the use of azole-based inhibitors of HO has been extended to other mammalian species and, as a consequence, it will be important to characterize the inhibitors in these species...
August 9, 2017: Canadian Journal of Physiology and Pharmacology
https://www.readbyqxmd.com/read/28792058/%C3%AE-dicyanovinyl-substituted-porphyrinogen-synthesis-a-reversible-sensor-for-picric-acid-among-explosives-and-a-unique-sensor-for-cyanide-and-fluoride-ions-by-switching-between-various-porphyrinoid-states
#19
Mandeep K Chahal, Muniappan Sankar
β-Dicyanovinyl substituted porphyrinogen (OxP-MN) was synthesized and utilized as a novel multifunctional sensor for the detection of biologically and environmentally important analytes. OxP-MN (1) acts as a selective and reversible probe for rapid colorimetric detection of picric acid (PA) among other nitroaromatics by switching between two porphyrinoid states. This system displayed a higher β2 value of 1.7 × 10(8) M(-2) and was able to detect PA down to 1.12 ppm (4.99 μM). β-Dicyanovinyl substituted porphyrinogen (OxP-MN) reported here contains a porphyrinogen anion binding site and a dicyanovinyl group as a cyanide-dependent reactive subunit...
August 9, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/28792018/supramolecular-five-component-nano-oscillator
#20
Debabrata Samanta, Indrajit Paul, Michael Schmittel
A five-component self-sorted metallo-supramolecular nano-oscillator was designed based on the full orthogonality of three different dynamic complexation motifs. The oscillating motion in the machinery, determined as 106 kHz at 25 °C by VT-NMR, arises due to dissociation/association of the pyridine terminal of the oscillator arm between two zinc(ii) porphyrin stations.
August 9, 2017: Chemical Communications: Chem Comm
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