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https://www.readbyqxmd.com/read/28548153/accelerating-chemical-reactions-by-molecular-sledding
#1
Lei Zhang, Lifei Zheng, Zhuojun Meng, Konstantin Balinin, Mark Loznik, Andreas Herrmann
The speed-up of covalent bond formation was achieved between a sulfhydryl group and a 2-bromopropionic acid derivative by utilizing sliding peptide-modified substrates. Moreover, a new type of DNA cleaving reagent was developed, consisting of pVIc covalently coupled to verteporfin. This peptide-porphyrin conjugate allowed targeting of DNA and resulted in increased photodegradation of double-stranded nucleic acids.
May 26, 2017: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/28545086/cancer-cell-spheroids-are-a-better-screen-for-the-photodynamic-efficiency-of-glycosylated-photosensitizers
#2
Patrícia M R Pereira, Naxhije Berisha, N V S Dinesh K Bhupathiraju, Rosa Fernandes, João P C Tomé, Charles Michael Drain
Photodynamic Therapy (PDT) relies on the use of non-toxic photosensitizers that are locally and selectively activated by light to induce cell death or apoptosis through reactive oxygen species generation. The conjugation of porphyrinoids with sugars that target cancer is increasingly viewed as an effective way to increase the selectivity of PDT. To date, in vitro PDT efficacy is mostly screened using two-dimensional monolayer cultures. Compared to monolayer cultures, three-dimensional spheroid cultures have unique spatial distributions of nutrients, metabolites, oxygen and signalling molecules; therefore better mimic in vivo conditions...
2017: PloS One
https://www.readbyqxmd.com/read/28544754/heterogeneous-integration-of-carbon-nanotube-graphene-for-high-performance-flexible-and-transparent-photodetectors
#3
Soonjae Pyo, Wondo Kim, Han-Il Jung, Jungwook Choi, Jongbaeg Kim
Low-dimensional carbon materials, such as semiconducting carbon nanotubes (CNTs), conducting graphene, and their hybrids, are of great interest as promising candidates for flexible, foldable, and transparent electronics. However, the development of highly photoresponsive, flexible, and transparent optoelectronics still remains limited due to their low absorbance and fast recombination rate of photoexcited charges, despite the considerable potential of photodetectors for future wearable and foldable devices...
May 24, 2017: Small
https://www.readbyqxmd.com/read/28544526/hetero-face-to-face-porphyrin-array-with-the-cooperative-effects-of-coordination-and-host-guest-complexation
#4
Yusuke Chiba, Maning Liu, Yasuhiro Tachibana, Tetsuaki Fujihara, Yasushi Tsuji, Jun Terao
We successfully synthesized a hetero face-to-face porphyrin array composed of ZnTPP and RuTPP(DABCO)₂ (TPP: 5,10,15,20-tetraphenylporphyrin, DABCO: 1,4-diazabi-cyclo[2.2.2]octane) in 2:1 molar ratio. A cyclic Zn porphyrin dimer (ZnCP) was also used as the host molecule for the Ru porphyrin. In the latter, the Ru-DABCO bonding in RuTPP(DABCO)₂ was stabilized by the host-guest complexation. Reaction progress kinetic analysis of the ligand substitution reaction of RuTPP(DABCO)₂ and that in ZnCP revealed the stabilization mechanism of the Ru-DABCO bonding...
May 22, 2017: Chemistry, An Asian Journal
https://www.readbyqxmd.com/read/28544383/self-assembled-biomimetic-chloroplast-coupled-photoenzymatic-reaction-for-sustainable-synthesis-of-fuel
#5
Xuehai Yan, Kai Liu, Chengqian Yuan, Qianli Zou, Zengchun Xie
Prototypes of biosystems provide good blueprints for the design and creation of biomimetic systems. However, mimicking both the sophisticated natural structures and their complex biological functions still remains a great challenge. Herein, biomimetic chloroplasts have been fabricated by one-step bio-inspired amino acid mineralization and simultaneous integration of catalytically active units. Hierarchically structured crystals are obtained by metal ion-directed self-assembly of cystine (the oxidized dimer form of the amino acid cysteine), with porous structure and stacking nanorods, which show similar architectural principles to chloroplasts...
May 22, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28543810/in-vitro-bactericidal-activity-of-blue-light-465-nm-phototherapy-on-meticillin-susceptible-and-meticillin-resistant-staphylococcus-pseudintermedius
#6
Amy H Schnedeker, Lynette K Cole, Gwendolen Lorch, Sandra F Diaz, John Bonagura, Joshua B Daniels
BACKGROUND: Staphylococcus pseudintermedius is the most common cause of bacterial skin infections in dogs. Meticillin-resistant infections have become more common and are challenging to treat. Blue light phototherapy may be an option for treating these infections. HYPOTHESIS/OBJECTIVES: The objective of this study was to measure the in vitro bactericidal activity of 465 nm blue light on meticillin-susceptible Staphylococcus pseudintermedius (MSSP) and meticillin-resistant Staphylococcus pseudintermedius (MRSP)...
May 22, 2017: Veterinary Dermatology
https://www.readbyqxmd.com/read/28540303/identifying-the-genes-responsible-for-iron-limited-condition-in-riemerella-anatipestifer-ch-1-through-rna-seq-based-analysis
#7
MaFeng Liu, Mi Huang, DeKang Zhu, MingShu Wang, RenYong Jia, Shun Chen, KunFeng Sun, Qiao Yang, Ying Wu, Francis Biville, AnChun Cheng
One of the important elements for most bacterial growth is iron, the bioavailability of which is limited in hosts. Riemerella anatipestifer (R. anatipestifer, RA), an important duck pathogen, requires iron to live. However, the genes involved in iron metabolism and the mechanisms of iron transport are largely unknown. Here, we investigated the transcriptomic effects of iron limitation condition on R. anatipestifer CH-1 using the RNA-Seq and RNA-Seq-based analysis. Data analysis revealed genes encoding functions related to iron homeostasis, including a number of putative TonB-dependent receptor systems, a HmuY-like protein-dependent hemin (an iron-containing porphyrin) uptake system, a Feo system, a gene cluster related to starch utilization, and genes encoding hypothetical proteins that were significantly upregulated in response to iron limitation...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28538687/on-forgotten-topological-indices-of-some-dendrimers-structure
#8
Yasir Bashir, Adnan Aslam, Muhammad Kamran, Muhammad Imran Qureshi, Adnan Jahangir, Muhammad Rafiq, Nargis Bibi, Nazeer Muhammad
A series of previously conducted experiments pertaining to various chemicals and drugs uncover a natural linkage between the molecular structures and the bio-medical and pharmacological characteristics. The forgotten topological index computed for the molecular structures of various chemical compounds and drugs has proven significant in medical and pharmaceutical fields by predicting biological features of new chemical compounds and drugs. A topological index can be considered as the transformation of chemical structure into a real number...
May 24, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28538099/iodide-selective-synthetic-ion-channels-based-on-shape-persistent-organic-cages
#9
Bahiru Punja Benke, Pulakesh Aich, Younghoon Kim, Kyung Lock Kim, Md Rumum Rohman, Soonsang Hong, In-Chul Hwang, Eun Hui Lee, Joon Ho Roh, Kimoon Kim
We report here a synthetic ion channel developed from a shape-persistent porphyrin-based covalent organic cage. The cage was synthesized by employing a synthetically economical dynamic covalent chemistry (DCC) approach. The organic cage selectively transports biologically relevant iodide ions over other inorganic anions by a dehydration-driven, channel mechanism as evidenced by vesicle-based fluorescence assays and planar lipid bilayer-based single channel recordings. Furthermore, the organic cage appears to facilitate iodide transport across the membrane of a living cell, suggesting that the cage could be useful as a biological tool that may replace defective iodide channels in living systems...
May 26, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28536715/hemin-catalyzed-sulfonium-ylide-formation-and-subsequently-reactant-controlled-chemoselective-rearrangements
#10
Xiaofei Xu, Chang Li, Mingteng Xiong, Zhihao Tao, Yuanjiang Pan
Hemin-catalyzed competing routes of [1,2]-Stevens and Sommelet-Hauser rearrangements of benzyl sulfonium ylides through an iron porphyrin carbenoid were established. These rearrangements can be controlled by the electronic property of the substituents on the benzyl group together with solvent effects. Electron-donating or weak electron-withdrawing groups lead to the [1,2]-Stevens rearrangement, whereas strong electron-withdrawing groups at the para-position favor the latter pathway under aqueous conditions.
May 24, 2017: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/28534917/charge-stabilizing-tris-triphenylamine-zinc-porphyrin-carbon-nanotube-hybrids-synthesis-characterization-and-excited-state-charge-transfer-studies
#11
Luis M Arellano, Myriam Barrejón, Habtom B Gobeze, María J Gómez-Escalonilla, José Luis G Fierro, Francis D'Souza, Fernando Langa
Functionalization of single-walled (SWCNTs) and double-walled carbon nanotubes (DWCNTs) with a charge stabilizing zinc porphyrin functionalized with triphenylamine entities has been accomplished. The synthetic approach involved the reaction of tris-(triphenylamine)porphyrinato zinc(ii) with iodobenzene functionalized nanotubes through a Sonogashira C-C cross coupling reaction under microwave irradiation conditions. Evidence of covalent functionalization and the extent of functionalization was obtained from systematic studies carried out by AFM, TGA, XPS and Raman spectroscopy techniques...
May 23, 2017: Nanoscale
https://www.readbyqxmd.com/read/28534586/desorption-of-co-from-individual-ruthenium-porphyrin-molecules-on-a-copper-surface-via-an-inelastic-tunnelling-process
#12
Takuma Omiya, Paolo Poli, Heike Arnolds, Rasmita Raval, Mats Persson, Yousoo Kim
The coordination of CO to metalloporphyrins changes their electronic and magnetic properties. Here we locally desorb CO molecules from a single ruthenium tetraphenylporphyrin carbonyl (CO-RuTPP) on Cu(110) using STM. The desorption is triggered by the injection of holes into the occupied states of the adsorbate using an unusual two-carrier process.
May 23, 2017: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/28534579/deprotonated-meso-hydroxyporphyrin-as-a-stable-%C3%AF-electronic-anion-the-building-unit-of-an-ion-pairing-assembly
#13
Yoshifumi Sasano, Nobuhiro Yasuda, Hiromitsu Maeda
The Ni(II) complex of 5-hydroxy-10,15,20-tris(pentafluorophenyl)-porphyrin was synthesized as the precursor of a negatively charged π-electronic system. Deprotonation, which was examined through UV/vis and (1)H NMR spectra, provided an anionic species as the building unit of an ion-pairing assembly in combination with an aliphatic cation.
May 23, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/28529668/diastereoselective-radical-type-cyclopropanation-of-electron-deficient-alkenes-mediated-by-the-highly-active-cobalt-ii-tetramethyltetraaza-14-annulene-catalyst
#14
Andrei Chirila, Braja Gopal Das, Nanda D Paul, Bas de Bruin
A new protocol for the catalytic synthesis of cyclopropanes using electron-deficient alkenes is presented, which is catalysed by a series of affordable, easy to synthesise and highly active substituted cobalt(II) tetraaza[14]annulenes. These catalysts are compatible with the use of sodium tosylhydrazone salts as precursors to diazo compounds in one-pot catalytic transformations to afford the desired cyclopropanes in almost quantitative yields. The reaction takes advantage of the metalloradical character of the Co complexes to activate the diazo compounds...
April 21, 2017: ChemCatChem
https://www.readbyqxmd.com/read/28525806/a-novel-porphyrin-based-molecular-probe-zntcppspm4-with-catalytic-stabilizing-and-chiroptical-diagnostic-power-towards-dna-b-z-transition
#15
Chiara M A Gangemi, Alessandro D'Urso, Gaetano A Tomaselli, Nina Berova, Roberto Purrello
In this work we have designed a new zinc(II) porphyrin with four spermines conjugate in the meso positions, meso-tetrakis-(4-carboxysperminephenyl)porphyrin, ZnTCPPSpm4) with the aim of acting as a chiroptical probe for the Z-form of DNA, a high energy transient conformation of DNA. In addition to monitor by Electronic Circular Dichroism chiroptical response the formation of Z-DNA in the presence of micromolar concentration of spermine, this porphyrin based molecular probe is also able to catalyze and stabilize this important DNA structure...
May 14, 2017: Journal of Inorganic Biochemistry
https://www.readbyqxmd.com/read/28525677/nonlinear-optical-properties-of-sodium-copper-chlorophyllin-in-aqueous-solution
#16
Jiangting Li, Yufeng Peng, Xueyun Han, Shaoshuai Guo, Kunning Liang, Minggao Zhang
BACKGROUND: Sodium copper chlorophyllin (SCC), as one of the derivatives of chlorophyll - with its inherent green features; good stability for heat, light, acids and alkalies; unique antimicrobial capability; and particular deodori zation performance - is widely applied in some fields such as the food industry, medicine and health care, daily cosmetic industry etc. SCC, as one of the metal porphyrins, has attracted much attention because of its unique electronic band structure and photon conversion performance...
May 19, 2017: Journal of Applied Biomaterials & Functional Materials
https://www.readbyqxmd.com/read/28523110/photodynamic-activities-of-porphyrin-derivative-cyclodextrin-complexes-by-photoirradiation
#17
Atsushi Ikeda, Shuhei Satake, Tomoya Mae, Masafumi Ueda, Kouta Sugikawa, Hajime Shigeto, Hisakage Funabashi, Akio Kuroda
Water-soluble cyclodextrin (CyD) complexed with porphyrin derivatives with different substituents in the meso-positions showed different photodynamic activities toward cancer cells under illumination at wavelengths over 600 nm, the most suitable wavelengths for photodynamic therapy (PDT). In particular, aniline- and phenol-substituted derivatives had high photodynamic activity because of the efficient intracellular uptake of the complexes by tumor cells. These complexes showed greater photodynamic activity than photofrin, currently the main drug in clinical use as a photosensitizer...
May 11, 2017: ACS Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/28521711/mini-heme-proteins-designability-of-structure-and-diversity-of-functions
#18
Jagdish Rai
Natural heme proteins may have heme bound to poly-peptide chain as a cofactor via non-covalent forces or heme as a prosthetic group may be covalently bound to the proteins. Nature has used porphyrins in diverse functions like electron transfer, oxidation, reduction, ligand binding, photosynthesis, signaling, etc. by modulating its properties through diverse protein matrices. Synthetic chemists have tried to utilize these molecules in equally diverse industrial and medical applications due to their versatile electro-chemical and optical properties...
May 15, 2017: Current Protein & Peptide Science
https://www.readbyqxmd.com/read/28520766/transcriptomic-analysis-of-salt-stress-responsive-genes-in-rhazya-stricta
#19
Nahid H Hajrah, Abdullah Y Obaid, Ahmed Atef, Ahmed M Ramadan, Dhivya Arasappan, Charllotte A Nelson, Sherif Edris, Mohammed Z Mutwakil, Alawia Alhebshi, Nour O Gadalla, Rania M Makki, Madgy A Al-Kordy, Fotouh M El-Domyati, Jamal S M Sabir, Mohammad A Khiyami, Neil Hall, Ahmed Bahieldin, Robert K Jansen
Rhazya stricta is an evergreen shrub that is widely distributed across Western and South Asia, and like many other members of the Apocynaceae produces monoterpene indole alkaloids that have anti-cancer properties. This species is adapted to very harsh desert conditions making it an excellent system for studying tolerance to high temperatures and salinity. RNA-Seq analysis was performed on R. stricta exposed to severe salt stress (500 mM NaCl) across four time intervals (0, 2, 12 and 24 h) to examine mechanisms of salt tolerance...
2017: PloS One
https://www.readbyqxmd.com/read/28518072/in-vivo-investigation-of-antimicrobial-blue-light-therapy-for-multidrug-resistant-acinetobacter-baumannii-burn-infections-using-bioluminescence-imaging
#20
Yucheng Wang, Olivia D Harrington, Ying Wang, Clinton K Murray, Michael R Hamblin, Tianhong Dai
Burn infections continue to be an important cause of morbidity and mortality. The increasing emergence of multidrug-resistant (MDR) bacteria has led to the frequent failure of traditional antibiotic treatments. Alternative therapeutics are urgently needed to tackle MDR bacteria. An innovative non-antibiotic approach, antimicrobial blue light (aBL), has shown promising effectiveness against MDR infections. The mechanism of action of aBL is not yet well understood. It is commonly hypothesized that naturally occurring endogenous photosensitizing chromophores in bacteria (e...
April 28, 2017: Journal of Visualized Experiments: JoVE
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