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https://www.readbyqxmd.com/read/29462790/fungal-lignin-peroxidase-does-not-produce-the-veratryl-alcohol-cation-radical-as-a-diffusible-ligninolytic-oxidant
#1
Carl J Houtman, Eranda Maligaspe, Christopher G Hunt, Elena Fernandez-Fueyo, Angel T Martínez, Kenneth E Hammel
Peroxidases are considered essential agents of lignin degradation by white-rot basidiomycetes. However, low-molecular-weight oxidants likely have a primary role in lignin breakdown because many of these fungi delignify wood before its porosity has sufficiently increased for enzymes to infiltrate. It has been proposed that lignin peroxidases (LiPs, EC 1.11.1.14) fulfill this role by oxidizing the secreted fungal metabolite veratryl alcohol (VA) to its aryl cation radical (VA+• ), releasing it to act as a one-electron lignin oxidant within woody plant cell walls...
February 9, 2018: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/29459927/silver-mediated-direct-c-h-amination-of-bodipys-for-screening-endoplasmic-reticulum-targeting-reagents
#2
Huaxing Zhang, Xingyu Chen, Jingbo Lan, Yanhong Liu, Fulin Zhou, Di Wu, Jingsong You
A highly efficient direct C-H amination of BODIPYs has been accomplished through the Ag(i)-mediated nucleophilic addition of an amino radical to BODIPY at the C3- and/or C5-position and deprotonation processes under mild conditions. This protocol greatly streamlines the access to a variety of 3-aminated and 3,5-diaminated BODIPYs. The resulting BODIPYs with morpholine groups (3q and 4b) exhibit specific endoplasmic reticulum (ER)-localization capacities and negligible cytotoxicities, which would be potential ER-targeting reagents...
February 20, 2018: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/29453982/glucagon-like-peptide-1-contributes-to-increases-abca1-expression-by-downregulating-mir-758-to-regulate-cholesterol-homeostasis
#3
Yue Yao, Qiang Li, Ping Gao, Wei Wang, Lili Chen, Jinchao Zhang, Yi Xu
Abnormal regulation of lipid metabolism is associated with type 2 diabetes mellitus (T2DM). GLP-1 as a new treatment for T2DM, has unique effects in modulating cholesterol homeostasis. However, the mechanism of this effect is largely missing. The aim of this study was to determine the effects of GLP-1 on cholesterol-induced lipotoxicity in hepatocytes and examine the underlying mechanisms. The cell viability was determined, and caspase-3 was used to detect the effects of GLP-1 on cholesterol-induced apoptosis...
February 14, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29451723/clickable-polyamine-derivatives-as-chemical-probes-for-the-polyamine-transport-system
#4
Roeland Vanhoutte, Jan Pascal Kahler, Shaun Martin, Sarah van Veen, Steven Verhelst
Polyamines are essential for cell growth and differentiation, but their trafficking by the polyamine transport system is not fully understood. In this paper, we describe the synthesis of several azido-derivatized polyamines for easy conjugation by click chemistry. Attachment of a BODIPY-dye gave fluorescent polyamine probes, which were tested in cell culture. The linear probe series showed superior cellular uptake compared with the probes where the dye was attached to a branch on one of the central amines. Interestingly, the linear probes accumulated rapidly in cancer cells (MCF-7), but not in non-tumorigenic cells (MCF-10A)...
February 16, 2018: Chembiochem: a European Journal of Chemical Biology
https://www.readbyqxmd.com/read/29446639/two-dimensional-electronic-spectroscopy-discloses-dynamics-and-mechanisms-of-solvent-driven-inertial-relaxation-in-polar-bodipy-dyes
#5
Luca Bolzonello, Annalisa Polo, Andrea Volpato, Elena Meneghin, Massimiliano Cordaro, Mariachiara Trapani, Mariagrazia Fortino, Alfonso Pedone, Maria Angela Castriciano, Elisabetta Collini
In this work, we demonstrate the use of 2D electronic spectroscopy (2DES) to study the mechanism and the timescale of the femtosecond Stokes shift dynamics in molecules characterized by intra-molecular charge transfer, such as distyryl-functionalized BODIPY molecules. The obtained results demonstrate that 2DES allows clear and direct visualization of the phenomenon. The analysis of the 2D data in terms of 2D frequency-frequency decay associated maps provides indeed not only the timescale of the relaxation process but also the starting and the final point of the energy flow and the associated reorganization energy, identifiable looking at the coordinates of a negative signature below diagonal...
February 15, 2018: Journal of Physical Chemistry Letters
https://www.readbyqxmd.com/read/29446426/time-dependent-aggregation-induced-emission-enhancement-and-the-study-of-molecular-packing-in-closely-related-azo-phenol-bodipy-species
#6
Rajendra Prasad Paitandi, Roop Shikha Singh, Bhupendra Kumar Dwivedi, Vishwa Deepak Singh, Daya Shankar Pandey
Fluorescent azo-phenol BODIPYs (1-3) have been obtained by the substituent (-OCH 3 /-CH 3 ) directed synthesis of ortho (L1) and para (L2-L3) azo-phenol aldehydes. These display aggregation caused quenching (ACQ, 1) and aggregation induced emission enhancement (AIEE, 2 and 3) depending on the position of azo relative to the phenolic hydroxyl group. An intriguing time dependent morphological transition from nanospheres to ordered nanorods and subsequent emission changes in AIEE active azo-phenol BODIPYs have been successfully realized by time dependent fluorescence, scanning electron (SEM), transmission electron (TEM) and fluorescence optical microscopy (FOM) studies...
February 15, 2018: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/29439250/hoxa5-promotes-adipose-differentiation-via-increasing-dna-methylation-level-and-inhibiting-pka-hsl-signal-pathway-in-mice
#7
Weina Cao, Yatao Xu, Dan Luo, Muhammad Saeed, Chao Sun
BACKGROUND/AIMS: Impaired adipogenesis may be the underlying cause in the development of obesity and type II diabetes. Mechanistically, the family of Homeobox transcription factors is implicated in the regulation of adipocyte fate. Hoxa5 is highly expressed in adipocytes, and its mRNA expression is decreased during differentiation. However, the function of Hoxa5 in adipose tissue has been poorly understood. The aim of this study is to unveil the role of Hoxa5 on adipocyte differentiation and its underlying mechanisms...
February 7, 2018: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29431798/boron-calixphyrin-complexes-exploring-the-coordination-chemistry-of-a-bodipy-porphyrin-hybrid
#8
Aaron Chin Yit Tay, Benjamin J Frogley, David C Ware, Penelope J Brothers
Boron complexes of calix[4]phyrins (1.1.1.1) were prepared by reacting the free-base ligands with BF3·Et2O. The reaction conditions can be efficiently tailored to produce mono- or di-boron calixphyrins. Mono-BF2 calixphyrins with boron coordinating to either the dipyrrin, BF2[H(Calix)], or dipyrromethane, BF2[H(Calix)] and BF2[H2(Calix)]+, bonding sites were isolated. The dipyrromethane isomer, BF2[H(Calix)], isomerises into BF2[H(Calix)] which kinetic studies and DFT calculations indicate is an intramolecular process...
February 12, 2018: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/29431773/a-near-infrared-fluorescent-probe-for-sensitive-detection-and-imaging-of-sulfane-sulfur-in-living-cells-and-in-vivo
#9
Xiaoyue Han, Xinyu Song, Bowei Li, Fabiao Yu, Lingxin Chen
Sulfane sulfur refers to ionized sulfur that is reversibly attached to other sulfur atoms in the form of 6-valence electrons (S0). Sulfane sulfur possesses stronger nucleophilicity and reducibility than hydrogen sulfide in a series of physiological reactions, which probably makes sulfane sulfur the actual signal molecule in cells. Herein, we designed and synthesized a near-infrared (NIR) fluorescent probe BD-diSH for sensitive detection and imaging of sulfane sulfur in living cells and in vivo. The probe BD-diSH is composed of two moieties: the fluorophore azo-BODIPY and the sulfane sulfur recognition unit, viz...
February 12, 2018: Biomaterials Science
https://www.readbyqxmd.com/read/29426487/a-novel-bodipy-based-fluorescent-probe-for-selective-detection-of-hydrogen-sulfide-in-living-cells-and-tissues
#10
Yan Ji, Li-Jun Xia, Liu Chen, Xiao-Feng Guo, Hong Wang, Hui-Juan Zhang
Hydrogen sulfide (H2S) is a critical biological messenger in numerous physiological and pathophysiological processes. Small-molecule fluorescent probes combined with fluorescent microscopy have been developed for the sensitive detection of H2S. Here, we designed and synthesized a long-wavelength BODIPY-based probe (TMSDNPOB) based on the thiolysis of dinitrophenyl ether according to photo-induced electron transfer theory and the results of computational calculation. 4,4-Difluoro-8-phenyl-1,5,7-trimethyl-3-(4-(2,4-dinitrophenoxy)styryl- 4-bora-3a,4a-diaza-s-indacene (TMSDNPOB) is nearly non-fluorescent, but the reaction product (TMSHOB) emits strong red fluorescence at 592nm when excited at 574nm...
May 1, 2018: Talanta
https://www.readbyqxmd.com/read/29414580/a-nir-bodipy-derivative-for-sensing-copper-ii-in-blood-and-mitochondrial-imaging
#11
Shao-Jun He, Yu-Wen Xie, Qiu-Yun Chen
In order to develop NIR BODIPY for mitochondria targeting imaging agents and metal sensors, a side chain modified BODIPY (BPN) was synthesized and spectroscopically characterized. BPN has NIR emission at 765nm when excited at 704nm. The emission at 765nm responded differently to Cu2+ and Mn2+ ions, respectively. The BPN coordinated with Cu2+ forming [BPNCu]2+ complex with quenched emission, while Mn2+ induced aggregation of BPN with specific fluorescence enhancement. Moreover, BPN can be applied to monitor Cu2+ in live cells and image mitochondria...
February 1, 2018: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/29411907/synthetic-approach-for-rapid-preparation-of-bodipy-conjugates-and-their-use-in-imaging-of-cellular-drug-uptake-and-distribution
#12
Sona Krajcovicova, Jarmila Stankova, Petr Dzubak, Marian Hajduch, Miroslav Soural, Milan Urban
Solid-phase synthetic (SPS) method was developed for the preparation of BODIPY-labeled bioactive compounds that allows for fast and simple synthesis of conjugates usable in fluorescent microscopy. The approach was used to visualize cellular uptake and distribution of cytotoxic triterpenes in cancer cells.
February 7, 2018: Chemistry: a European Journal
https://www.readbyqxmd.com/read/29411306/relaxin-activates-ampk-akt-signaling-and-increases-glucose-uptake-by-cultured-cardiomyocytes
#13
A Aragón-Herrera, S Feijóo-Bandín, D Rodríguez-Penas, E Roselló-Lletí, M Portolés, M Rivera, M Bigazzi, D Bani, O Gualillo, J R González-Juanatey, F Lago
PURPOSE: Many evidences show that the hormone relaxin plays a pivotal role in the physiology and pathology of the cardiovascular system. This pleiotropic hormone exerts regulatory functions through specific receptors in cardiovascular tissues: in experimental animal models it was shown to induce coronary vasodilation, prevent cardiac damage induced by ischemia/reperfusion and revert cardiac hypertrophy and fibrosis. A tight relationship between this hormone and important metabolic pathways has been suggested, but it is at present unknown if relaxin could regulate cardiac metabolism...
February 6, 2018: Endocrine
https://www.readbyqxmd.com/read/29405716/pony-dyes-direct-addition-of-p-iii-nucleophiles-to-organic-fluorophores
#14
Alexey N Butkevich, Maksim V Sednev, Heydar Shojaei, Vladimir N Belov, Stefan W Hell
Nucleophilic addition of phosphinic acid, phosphites, sodium dialkyl phosphites, phosphoramidites, phosphinites, and phosphonites to highly polarized or cationic fluorophores, followed by oxidation, results in new "PONy" dyes with auxochromic phosphinate, phosphonate, or phosphonamidate groups. The reaction was applied to a wide variety of coumarins, (thio)pyronins, and N-alkylacridinium and 5,6-dihydrobenzo[c]xanthen-12-ium salts as well as a meso-chlorinated BODIPY to provide compact dyes with red-shifted absorption and emission bands and Stokes shifts up to 8200 cm-1...
February 6, 2018: Organic Letters
https://www.readbyqxmd.com/read/29400953/glucose-appended-platinum-ii-bodipy-conjugates-for-targeted-photodynamic-therapy-in-red-light
#15
Vanitha Ramu, Srishti Gautam, Aditya Garai, Paturu Kondaiah, Akhil R Chakravarty
Platinum(II) complexes [Pt(L1)(R-BODIPY)]Cl (1) and [Pt(L2)(R-BODIPY)]Cl (2), where R-BODIPY is 8-(4-ethynylphenyl)-distyryl-4,4-difluoro-5,7-dimethyl-4-bora-3a,4a-diaza-s-indacene-3, L1 is 4'-phenyl-2,2':6',2″-terpyridine, and L2 is (2,2':6',2″-terpyridin-4'-oxy)ethyl-β-d-glucopyranoside, were synthesized and characterized, and their photocytotoxicity was studied. The phenylacetylide complex [Pt(L1)(C≡CPh)]Cl (3) was prepared and used as a control. Complexes 1 and 2 showed near-IR absorption bands at 713 nm (ε = 3...
February 5, 2018: Inorganic Chemistry
https://www.readbyqxmd.com/read/29385317/design-and-synthesis-of-a-bodipy-tetrazole-based-off-on-in-cell-fluorescent-reporter-of-hydrogen-peroxide
#16
Qing Lin, Peng An, Tracey M Lewandowski
The BODIPY-linked bithiophene-tetrazoles were designed and synthesized for bioorthogonal photoclick reactions in vitro and in vivo. The reactivity of these tetrazoles toward dimethyl fumarate was found to depend on BODIPY attachment site, with the meta-linked BODIPY-tetrazole being the most reactive. The resulting BODIPY-pyrazolines showed drastically reduced BODIPY fluorescence. Interestingly, the BODIPY fluorescence recovered after treatment with hydrogen peroxide, which was attributed to the conversion from the pyrazoline to the pyrazole...
January 31, 2018: Chembiochem: a European Journal of Chemical Biology
https://www.readbyqxmd.com/read/29384535/tracking-hocl-concentrations-across-cellular-organelles-in-real-time-using-a-super-resolution-microscopy-probe
#17
Firoj Ali, Sunil Aute, Sreejesh Sreedharan, H A Anila, Hiwa K Saeed, Carl G Smythe, Jim A Thomas, Amitava Das
BODIPY derivative, SF-1, exclusively shows a fluorescence ON response to HOCl and images endogenously generated HOCl in RAW 264.7 macrophages. Widefield and super resolution structured illumination microscopy images confirm localization in the Golgi complex and lysosomes, and hence specifically detects HOCl generated in these organelles. SF-1 is compatible with 3D-SIM imaging of individual cells.
January 31, 2018: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/29377582/near-infrared-bodipy-for-bioimaging-and-photothermal-therapy
#18
Yang Liu, Nan Song, Li Chen, Shi Liu, Zhigang Xie
It is challenging to develop robust photothermal agents with near-infrared (NIR) imaging simultaneously. In this work, a new photothermal agent was designed and synthesized based on aza-boron-dipyrromethene (aza-BDP). The aza-BDP possesses excellent photostability and higher photothermal conversion efficiency (50%) under NIR laser irradiation. When the photothermal effects were utilized for tumor inhibition, long term stable fluorescence was observed in living animals. The photothermal treatment can efficiently suppress the tumor growth, which was evidenced by in vitro and in vivo experiments...
January 28, 2018: Chemistry, An Asian Journal
https://www.readbyqxmd.com/read/29369628/green-light-sensitive-bodipy-photoprotecting-groups-for-amines
#19
Kaja Sitkowska, Ben L Feringa, Wiktor Szymanski
We describe a series of easily accessible, visible light sensitive (λ > 500 nm) BODIPY (boron-dipyrromethene)-based photoprotecting groups (PPGs) for primary and secondary amines, based on a carbamate linker. The caged compounds are stable under aqueous conditions for 24 h and can be efficiently uncaged in vitro with visible light (λ = 530 nm). These properties allow efficient photodeprotection of amines, rendering these novel PPGs potentially suitable for various applications, including delivery of caged drugs and their remote activation...
January 25, 2018: Journal of Organic Chemistry
https://www.readbyqxmd.com/read/29369311/the-janus-faced-chromophore-a-donor-acceptor-dyad-with-dual-performance-in-photon-up-conversion
#20
Natalia Kiseleva, Mikhail A Filatov, Michael Oldenburg, Dmitry Busko, Marius Jakoby, Ian A Howard, Bryce S Richards, Mathias O Senge, Sergey M Borisov, Andrey Turshatov
An electron donor-acceptor dyad based on BODIPY (acceptor) and anthracene (donor) plays either the role of sensitizer or emitter in triplet-triplet annihilation photon up-conversion (TTA-UC). This Janus-like behavior was achieved via altering the relative ordering of charge-transfer and local excited state energies in the dyad through the polarity of TTA-UC media.
January 25, 2018: Chemical Communications: Chem Comm
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