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best dyspepsia medicine

Rolf Teschke, Albrecht Wolff, Christian Frenzel, Axel Eickhoff, Johannes Schulze
Herbal traditional Chinese medicine (TCM) is used to treat several ailments, but its efficiency is poorly documented and hence debated, as opposed to modern medicine commonly providing effective therapies. The aim of this review article is to present a practical reference guide on the role of herbal TCM in managing gastrointestinal disorders, supported by systematic reviews and evidence based trials. A literature search using herbal TCM combined with terms for gastrointestinal disorders in PubMed and the Cochrane database identified publications of herbal TCM trials...
April 21, 2015: World Journal of Gastroenterology: WJG
Ri-Xin Chen, Ming-Fei Kang, Ming-Ren Chen
To discuss the hypothesis of the sensitization state of acupoints based on the original definition and the localization method of acupoint from Internal Classic as well as the clinical evidence of heat-sensitive moxibustion. Acupoints are different in the states, named resting and sensitization. The acupoints of sensitization state are the reactive sites of disease on the body surface, also the best sites for acupuncture and moxibustion treatment. The acupoints are the specific sensitive sites on the body surface relevant with diseases with the best therapeutic effects...
February 2011: Zhongguo Zhen Jiu, Chinese Acupuncture & Moxibustion
N Egloff, C Beer, J M Gschossmann, A Sendensky, R von Känel
A multimodal approach is state-of-the art for effective treatment of functional gastrointestinal disorders (FGD) like irritable bowel syndrome and functional dyspepsia. Based on the now established view that the pathogenesis of FGD is multicausal, evidence-based therapeutic options comprise education about the nature of the disorder, dietary modifications, relaxation techniques, behavioral changes, and pharmacological treatments. These therapies are variously combined depending on the severity of the FGD and the individual needs of the patient...
April 14, 2010: Praxis
Diana Aulia, Gaby Octavia Manz, Marcellus Simadibrata
AIM: To study Pepsinogen I (PG I) concentration in atrophic chronic gastritis (ACG) and non-atrophic chronic gastritis (NACG) patients with or without H. pylori infection compared to gastroscopy and biopsy as the gold standard. METHODS: The study subjects consisted of 70 organic dyspepsia patients who underwent esofago gastroduodenoscopy (EGD) at the Gastroenterology Outpatient Clinic Department of Internal Medicine Cipto Mangunkusumo Hospital. Pepsinogen I tests were performed using ELISA with Human Pepsinogen I ELISA kit from Biohit...
July 2009: Acta Medica Indonesiana
Eamonn M M Quigley, Fergus Shanahan
Progress in complex disorders requires clear thinking facilitated by clear language. Clinicians and scientists occasionally become captive to inaccurate language or meaningless terminology and this generates lazy thinking and impedes progress. Has this happened in the case of the functional gastrointestinal disorders (FGIDs), in general, and irritable bowel syndrome (IBS), in particular? FGIDs and, especially IBS, are common illnesses and an important burden on healthcare resources but, in general, have suffered from a lack of progress in the development of safe and effective treatment...
April 2009: Clinical Medicine: Journal of the Royal College of Physicians of London
Smita L S Halder, Nicholas J Talley
Functional dyspepsia (FD) is a condition commonly seen in gastroenterological practice. With the introduction of Rome III criteria in 2006, a new approach for categorizing patients has been recommended. The diagnostic criteria suggest that meal-related and pain-predominant symptom groupings that presumably have distinct pathophysiologic mechanisms and potentially different therapeutic targets exist. The new classification is in the early stages of testing; in the meantime, the umbrella term of FD should continue to be utilized in clinical practice...
August 2007: Current Treatment Options in Gastroenterology
Jason Bowman, Jeffrey Jones
A short-cut review was carried out to establish whether lidocaine is a useful adjuvant in the gastrointestinal cocktail of dyspepsia treatment. 325 citations were reviewed, of which two answered the three-part question. The clinical bottomline is that antacid alone should be used as preferred treatment for dyspesia. The addition of lidocaine and donnatal can be used on doctor's discretion in patients without contraindications to these agents.
November 2006: Emergency Medicine Journal: EMJ
H Schempp, D Weiser, O Kelber, E F Elstner
A combination of ethanolic extracts from nine medicinal plants is successfully used in STW 5 (Iberogast((R))) for treatment of gastrointestinal disorders. To elucidate possible modes of action, the focus of this study is on antioxidant properties of the phytomedicine STW 5. In fact, functional gastrointestinal diseases, such as non-ulcer dyspepsia (NUD) and irritable bowel syndrome, are often initiated by or correlated to inflammatory processes, where oxidants such as reactive oxygen species (ROS) play a crucial role...
2006: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
V Andresen, M Camilleri
There is a need to have predictive biomarkers to test novel experimental medicines in functional gastrointestinal disorders (FGID). The human pharmacodynamic models and biomarkers in functional dyspepsia (part I) and visceral pain (part II) are reviewed, including the general challenges of these two disorders (part I). Part II will also discuss the importance of drug pharmacokinetics and potential of pharmacogenomics, including the influence of CYP metabolism and potential drug interactions. The great heterogeneity of mechanisms potentially responsible for dyspeptic symptoms adds a significant complexity to this FGID...
May 2006: Neurogastroenterology and Motility: the Official Journal of the European Gastrointestinal Motility Society
D Lutchman, S Pillay, R Naidoo, N Shangase, R Nayak, A Rughoobeer
BACKGROUND: Non-ulcer dyspepsia (NUD) is the term most commonly used to describe a heterogeneous and often ill-defined group of dyspepsia patients whose symptoms of upper abdominal pain, discomfort or nausea persist in the absence of identifiable cause. Treatment choice commonly includes over the counter medicines and home remedies, e.g. milk. OBJECTIVE: To determine the relative buffering capacity of goat's, cow's and soy milk, non-prescription antacid drugs and combinations thereof...
January 2006: South African Medical Journal, Suid-Afrikaanse Tydskrif Vir Geneeskunde
Smita L S Halder, Nicholas J Talley
Functional dyspepsia (FD) is a common reason a patient presents with upper gastrointestinal symptoms for medical care. Although treatment of FD remains expensive, the agents are rarely used in a systematic manner; the majority of treatments are empirical and the results short lived once therapy is ceased. This is partly due to the lack of consistent pathophysiologic markers in FD, so therapy is symptom driven. This review appraises the best evidence on available interventions. A structured scheme for deciding on appropriate therapies is to consider the possible putative pathophysiologic mechanisms...
August 2005: Current Treatment Options in Gastroenterology
L I Spirling, I R Daniels
Throughout history different species of mint have been used across the globe for their varying properties, both medicinal and culinary. Today, the commercial sales of mints are expanding each year--and at the end of a large meal after-dinner mints are frequently served. But why do we take them? Peppermint (Mentha piperita) is usually taken after a meal for its ability to reduce indigestion and colonic spasms by reducing the gastrocolic reflex. It is a naturally occurring hybrid cross between water mint (M. aquatica) and spearmint (M...
March 2001: Journal of the Royal Society for the Promotion of Health
S J Veldhuyzen van Zanten, N Flook, N Chiba, D Armstrong, A Barkun, M Bradette, A Thomson, F Bursey, P Blackshaw, D Frail, P Sinclair
OBJECTIVES: To provide Canadian primary care physicians with an evidence-based clinical management tool, including diagnostic and treatment recommendations, for patients who present with uninvestigated dyspepsia. RECOMMENDATIONS: The management tool has 5 key decision steps addressing the following: (1) evidence that symptoms originate in the upper gastrointestinal tract, (2) presence of alarm features, (3) use of nonsteroidal anti-inflammatory drugs (NSAIDs), (4) dominant reflux symptoms and (5) evidence of Helicobacter pylori infection...
June 13, 2000: CMAJ: Canadian Medical Association Journal, Journal de L'Association Medicale Canadienne
C W Howden
Evidence-based medicine combines clinical expertise and the best available evidence from systematic research to aid decision making in patient care. Levels of evidence can be graded from I to V, with level I, the strongest, coming from large randomized controlled trials (RCTs). When a definitive RCT has not been performed, or is impracticable or inappropriate, lesser grades of evidence are used. There is level I evidence supporting the treatment of Helicobacter pylori infection in patients with duodenal or gastric ulcers...
December 1997: Gastroenterology
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