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Ahmad Separham, Samad Ghaffari, Hossein Najafi, Reza Ghaffari, Mojtaba Ziaee, Hossein Babaei
Allopurinol may have protective effects over ischemic reperfusion injury and reduce infarct size. In this randomized study, we aimed to evaluate the impact of allopurinol in patients with acute ST elevation myocardial infarction (STEMI) undergoing thrombolytic therapy. Overall, 140 patients with STEMI were randomly assigned to receive 400 mg of allopurinol or placebo before treating with streptokinase. Then, study group received 100 mg of allopurinol daily for 28 days and placebo group received placebo for the same period...
October 2016: Journal of Cardiovascular Pharmacology
Trinath Kumar Mishra, Biswajit Das
BACKGROUND: Coronary artery disease (CAD) is rising in epidemic proportions with India not being an exception. CAD in Indian scenario has its onset at a younger age with multitude of risk factors. OBJECTIVE: This study was carried out to obtain complete information about demographic profile, risk factors, clinical scenario, therapeutic modalities, natural course, outcome and changing profile of acute ST-segment elevated myocardial infarction (STEMI) patients. METHODS: This cross-sectional study was conducted in 45,122 acute STEMI patients admitted 1st March 1990 to 1st March 2014...
June 2016: Journal of the Association of Physicians of India
Achintya Pal, A Datta, A K Bhattacharyya
No abstract text is available yet for this article.
January 2016: Journal of the Association of Physicians of India
X Y Liu, Y Zhang, M W Li, X P Wang, D D Qi, P Y Hao, H Zhang, Q Q Cheng, L S Zhao, C Y Gao, D Y Hu
Objective: To evaluate the efficacy and safety of intravenous thrombolytic therapy using reteplase in patients with acute ST-segment elevation myocardial infarction (STEMI). Method: A total of 73 hospitals from Henan province took part in this clinical trials during October 2012 to October 2014, 1 226 cases (1 014 male (82.7%), mean age 59.0 (51.0, 66.0) years) with acute STEMI received reteplase as thrombolytic agent.Reperfusion rate was judged according to the clinical symptoms, electrocardiogram, myocardial enzymes and heart rhythm, and the rate of cardiovascular events and bleeding events during hospitalization was also observed...
September 24, 2016: Zhonghua Xin Xue Guan Bing za Zhi
Satyavan Sharma, Nikhil Raut, Anil Potdar
AIM: Spontaneous coronary artery dissection (SCAD) is a less recognized cause of ST elevation myocardial infarction (STEMI) in clinical practice. The aim of this communication is to describe a case series in South Asian population and highlight on the long-term clinical outcomes on conservative management. METHODS: A retrospective analysis of data of five patients (6 instances) of SCAD managed in a tertiary care center during January 1994 to June 2015 was done. Clinical, angiographic, therapeutic, and follow-up data till end of June 2015 are analyzed...
July 2016: Indian Heart Journal
Selami Doğan, Hüseyin Dursun, Hüseyin Can, Hülya Ellidokuz, Dayimi Kaya
BACKGROUND/AIM: The aim of this study was to determine the patient profile, treatment, and outcomes of a coronary care unit (CCU) by retrospective screening of 12-year patient records. MATERIALS AND METHODS: The data of 13,463 patients admitted to the CCU of a tertiary referral hospital between 1 January 1997 and 30 June 2008 were collected. The patients were assessed with respect to demographics, admission diagnosis, treatment, and outcomes. RESULTS: The mean age of patients was 61 ± 13 years (66...
2016: Turkish Journal of Medical Sciences
Ashar Khan, Shoeb Nadeem, Hemant Kokane, Ankur Thummar, Yash Lokhandwala, Ajay U Mahajan, Pratap J Nathani
BACKGROUND: Accelerated idioventricular rhythm (AIVR) is a common arrhythmia observed in patients with ST segment elevation myocardial infarction (MI). It is not clear how much value AIVR has in predicting successful reperfusion, since there have been conflicting data regarding this in the past. Streptokinase (STK) even today is the commonest thrombolytic agent used in the public health care set-up in India.(1) Most data for the use of STK are from the 1990s, which had showed that at best it is effective in only 50% of patients in restoring adequate flow...
May 2016: Indian Heart Journal
Younes Nozari, Masih Tajdini, Mehdi Mehrani, Rosa Ghaderpanah
Distinguishing ST-elevation myocardial infarction (STEMI) differential diagnoses is more challenging. Myopericarditis is one of these differentials that results from viral involvement of myocardium and pericardium of the heart. Myopericarditis in focal form can mimic acute STEMI in its electrocardiogram (ECG) features and elevated cardiac enzymes. Myocarditis patients may face thrombolytic related complications such as intracranial bleeding, myocardial rupture, and hemorrhagic cardiac tamponade. Furthermore, re-administration of streptokinase (a common thrombolytic agent in our country) is banned for at least six months of previous administration; however, it can save patients' lives in emergency conditions such as massive pulmonary embolism...
2016: Emergency (Tehran, Iran)
Ivan Ilić, Ivan Stanković, Radosav Vidaković, Aleksandra Janićijević, Milivoje Cerović, Vladimir Jovanović, Aleksandar Aleksić, Gojko Obradović, Ivica Nikolajević, Srdjan Kafedzić, Dusan Milicević, Jovana Kusić, Biljana Putniković, Aleksandar N Nesković
INTRODUCTION: Data on effects of thrombus aspiration on left ventricular diastolic function in ST-elevation myocardial infarction (STEMI) population are scarce. OBJECTIVE: We sought to compare echocardiographic indices of the diastolic function and outcomes in STEMI patients treated with and without manual thrombus aspiration, in an academic, high-volume percutaneous coronary intervention (PCI) center. METHODS: A total of 433 consecutive patients who underwent primary PCI in 2011-2012 were enrolled in the study...
January 2016: Srpski Arhiv za Celokupno Lekarstvo
Marija Vavlukis, Irina Kotlar, Emilija Chaparoska, Bekim Pocesta, Hristo Pejkov, Marjan Boshev, Sasko Kedev
AIM: We are presenting an uncommon case of pulmonary embolism, followed with an acute myocardial infarction, in a patient with progressive systemic sclerosis. CASE PRESENTATION: A female 40 years of age was admitted with signs of pulmonary embolism, confirmed with CT scan, which also reviled a thrombus in the right ventricle. The patient had medical history of systemic sclerosis since the age of 16 years. She suffered an ischemic stroke 6 years ago, but she was not taking any anticoagulant or antithrombotic medications ever since...
December 15, 2015: Open Access Maced J Med Sci
Farhin Iqbal, J C Barkataki
AIM: Spectrum of acute coronary syndrome (ACS) has not been reported from North Eastern India. The present study was undertaken to study the clinical spectrum of ACS. METHODS: We prospectively collected data of 704 ACS patients from February 2011 to August 2012 in Gauhati Medical College, a tertiary care center. We evaluated data on clinical characteristic, treatment, and outcome in ACS patients. RESULTS: Of the 704 ACS patients, 72.4% presented with STEMI and 27...
March 2016: Indian Heart Journal
Prakash Chand Negi, Rajeev Merwaha, Deveshwar Panday, Vivek Chauhan, Rajesh Guleri
BACKGROUND: No population representative data on characteristics, treatment, and outcome were available in acute coronary syndrome (ACS) patients. METHODS: The clinical characteristics, treatment, and in-hospital outcome of 5180 ACS patients registered in multicenter ACS Registry across 33 hospitals in the state since January 2012 to December 2014 are reported. ACS was diagnosed using standard criteria. RESULT: 70.8% were men; mean age was 60...
March 2016: Indian Heart Journal
Sameer Saleem, Adnan Khan, Ihtesham Shafiq
OBJECTIVE: To study the effect of timing of thrombolytic therapy, cardiac risk factors and site of infarction on S.T. resolution post thrombolysis in STEMI patients. METHODS: This was a descriptive hospital based study conducted at the Hayatabad Medical Complex Peshawar. The duration of our study was 5 months from February 2015 to June 2015. Diagnosis of STEMI in symptomatic patients was based on the ECG recognized. Definition of Myocardial Infarction. Time from onset of chest pain to presentation of patients in emergency was noted through history of patients along with time of streptokinase...
January 2016: Pakistan Journal of Medical Sciences Quarterly
Xiaohui Chen, Min Li, Huilin Jiang, Yunmei Li, Junrong Mo, Peiyi Lin, Colin A Graham, Timothy H Rainer
BACKGROUND AND OBJECTIVES: Healthcare systems are organized very differently in Hong Kong (HK) and Guangzhou (GZ). This study compared managements of the emergency departments (ED) and one-year mortalities of ST-segment elevation myocardial infarction (STEMI) patients in two teaching hospitals in Guangzhou and Hong Kong. METHODS: Retrospective observational study of STEMI mortalities and treatments in the Prince of Wales Hospital (PWH) and the Second Affiliated Hospital of Guangzhou Medical University (AHGZMU), was conducted between January and December 2010...
2016: PloS One
Fernando Gonzalez, Christophe Marti, Maria Chrysafi, Nicolas Beysard, Olivier Grosgurin, Pierre-Nicolas Carron, Olivier Rutschmann
The year 2015 was marked by several publications questioning the practice of emergency medicine. The systematic administration of oxygen in STEMI patients offers no benefit. Similarly, medical expulsive therapy in patients with ureteric stones was questioned. Administration of steroids for acute radiculopathy showed only short-term, but no mid-term pain improvement. Several studies have demonstrated the benefit combining intraarterial and intravenous thrombolytic therapy for ischemic stroke. However, studies assessing optimal management strategy for patients hospitalized with community acquired pneumonia, showed conflicting results...
January 13, 2016: Revue Médicale Suisse
R Y Guo, Y F Wu, W Zhao, S S Li, M Li, X Du, X Li, G Q Xie, R L Gao
OBJECTIVE: To explore the impact of thrombolytic therapy time delay on in-hospital major adverse cardiac event rate in patients with acute ST-segment elevation myocardial infarction (STEMI). METHODS: This survey was performed in 101 level 2 hospitals from 15 provinces or autonomous region in China. Patients admitted to these hospitals with acute STEMI during November 2011 to November 2014 and received thrombolytic therapy were eligible for this study. Multivariate logistic regression modeling was used to estimate the rate of in-hospital major adverse cardiac events (re-infarction, stroke and all-cause mortality) in patients with different thrombolytic time delay...
February 2016: Zhonghua Xin Xue Guan Bing za Zhi
Hong Zhang, Yong-chun Cui, Yi Tian, Wei-min Yuan, Jian-zhong Yang, Peng Peng, Kai Li, Xiao-peng Liu, Dong Zhang, Ai-li Wu, Zhou Zhou, Yue Tang
BACKGROUND: There is still no standard large animal model for evaluating the effectiveness of potential thrombolytic therapies. Here, we aimed to develop a new beagle model with ST-elevation myocardial infarction (STEMI) by injecting autologous emboli with similar components of coronary thrombus. METHODS: 18 male beagles were included and divided into three groups: red embolus group (n = 6), white embolus group (n = 6) or white embolus + rt-PA group (n = 6). Autologous emboli were infused into the mid-distal region of the left anterior descending coronary artery...
2016: BMC Cardiovascular Disorders
Islam El-Sherbiny, Baher Nabil, Tamer Saber, Fathy Elsayed Abdelgawad
We aimed to assess the predictive value of admission HbA1c level in nondiabetic patients presented by acute STEMI, on outcome of PCI and short term outcome of adverse cardiac events. Methods. 60 nondiabetic patients were admitted to Cardiology Department, Zagazig University Hospital, with acute STMI: 27 patients with HbA1c levels of 4.5% to 6.4% (group 1), 17 patients with HbA1c levels of 6.5% to 8.5% (group 2), and 16 patients with HbA1c levels higher than 8.5% (group 3). Either invasive intervention was done at admission by (pPCI) or coronary angiography was done within month (3-28 days) from taking thrombolytic...
2015: Cardiology Research and Practice
Seyed Ebrahim Kassaian, Farzad Masoudkabir, Hashem Sezavar, Mohammad Mohammadi, Ali Pourmoghaddas, Javad Kojouri, Samad Ghaffari, Hamidreza Sanaati, Farshid Alaeddini, Bahin Pourmirza, Elham Mir
OBJECTIVES: To assess contemporary data on characteristics, management and 1-year postdischarge outcomes in Iranian patients hospitalised with acute coronary syndrome (ACS). SETTING: 11 tertiary care hospitals in 5 major cities in the Islamic Republic of Iran. PARTICIPANTS: Patients aged ≥ 20 and ≤ 80 years discharged alive with confirmed diagnosis of ACS including ST-segment elevation myocardial infarction (STEMI), non-STEMI (NSTEMI) and high-risk unstable angina (HR-UA)...
2015: BMJ Open
R K Singh, A Trailokya, M M Naik
BACKGROUND: ST elevated myocardial infarction is a serious and life-threatening condition. In patients suitable for thrombolytic treatment, time is critical and reperfusion should be initiated as soon as possible. Reteplase is commonly used in the management of ST elevated myocardial infarction. OBJECTIVE: To assess the safety and efficacy of intravenous Retelex (Reteplase) injection in management of patients with ST elevated myocardial infarction in clinical practice...
April 2015: Journal of the Association of Physicians of India
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